Errata at end of text. Book.
0000 - Gale Group | The Making of Modern World
Mouhamed Yazan Abou‐Ismail, Sargam Kapoor, Divyaswathi Citla Sridhar, Lalitha Nayak, Sanjay Ahuja,
... this illustrated review, we focus on thrombotic thrombocytopenic purpura (TTP), Shiga toxin–associated hemolytic uremic syndrome, complement- ... on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. J Thromb Haemost. 2017; ... George JN. Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired ADAMTS13 deficiency: comparison of ... 12Kremer Hovinga JA, George JN. Hereditary thrombotic thrombocytopenic purpura. N Engl J Med. 2019; 381(17): 1653- ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2022 - Elsevier BV | Research and Practice in Thrombosis and Haemostasis
Dr. George Johnson, Dr. Robert Gee, William Eddowes, Dr. W. J. Cummins, James Laird, Dr. William Jenner, Dr. G. Owen Rees, H. Bence Jones, J. Taylor, Dr. George Johnson, Dr. George Johnson, Dr. George Johnson, Henry Bowe, Dr. John Charles Bucknill, W. C. Williamson, Dr. Frederick J. Lowes, R. B. Todd, Dr. W. Senhouse Kirkes, Dr. W. T. Gairdner, Dr. Theophilus Thompson, Henry Ancell, Dr. William Jenner, Dr. Edward Henry Sieveking, Dr. W. O. Markham, Dr. George Corfe, Dr. Thomas Inman, Dr. Fleetwood Churchill, Dr. Eben Watson, Henry Smith, Dr. Cornelius Black, Dr. G. E. Day, Dr. C. Hanfield Jones, Dr. R. Neale, John Marshall, Dr. George Budd, M. Bernard, Dr. William D. Moore, Dr. Robert Christison, Dr. Robert B. Todd, Dr. Robert Christison, Dr. C. Hanfield Jones, C. Hanfield Jones, Dr. George Johnson, Dr. George Burrows, Dr. W. Senhouse Kirkes, M. Schutzenberger, Dr. Robert B. Todd, Henry Greenway, R. J. MacKenzie, Henry Smith, George M. Jones, Dr. Charles Edwards, Dr. William Hales Hingston, Dr. Philip Frank, Samuel Solly, William Lawrence, Edmund U. Eyre, Wm. Adams, M. Bonnet, Dr. Daniel Brainard, Dr. Charles Edwards, Dr. George Haywood, W. S. Savory, G. J. Guthrie, Alfred Baker, William James Clement, Dr. William MacDonald, Dr. W. S. Oke, William Reeves, Edward Cock, F. A. Bulley, E. Stanley, John L. Milton, John L. Milton, Thomas Hunt, Dr. William Jenner, Dr. E. A. Parkes, Robert Crawford, Fred. James Brown, John Higginbottom, Richard Flint, John Gay, T. Spencer Wells, John France, Dr. Daniel Griffin, Benjamin Bell, Henry Hancock, John F. France, T. Spencer Wells, William Bowman, Joseph Toynbee, Dr. T. E. Rawson, W. Boyle Chavasse, R. C. Shettle, John Traill, Henry Rudge, John Gregory Forbes, Dr. John Rose Cormack, Dr. J. F. Peebles, M. Desgranges, M. R. Virchow, Dr. Robert Lee, Dr. W. S. Oke, W. S. Oke, W. S. Oke, Dr. T. H. Tanner, Dr. W. Tyler Smith, E. R. Bickersteth, Edward William Lowe, Benjamin Travers Jr., T. P. J. Grantham, Wm. Smith, M. Aran, Benjamin W. Richardson, Dr. P. J. Murphy, W. Tiffin Iliff Jr.,
... Galvanism, On Gallic Acid in the Treatment of Purpura Hæmorrhagica, On the Use of Cinnamon in Certain ... Leeds General Infirmary, Turpentine in the Treatment of Purpura, On Cramp and Spasm, Case of Turning Instead ...
1854 - Gale Group | NCCO-STM 1of2
Adrien Picod, Jean-Michel Rebibou, Antoine Dossier, Bérengère Cador, David Ribes, Claire Vasco‐Moynet, Caroline Stephan, Mathieu Bellal, Alain Wynckel, Pascale Poullin, Edwige Péju, Laure Ricard, Jean‐Emmanuel Kahn, Raïda Bouzid, Y. Benhamou, Bérangère S. Joly, Agnès Veyradier, Paul Coppo,
... Blood| April 21, 2022 Immune-mediated thrombotic thrombocytopenic purpura following COVID-19 vaccination Clinical Trials & Observations Adrien ... Agnès Veyradier, Paul Coppo; Immune-mediated thrombotic thrombocytopenic purpura following COVID-19 vaccination. Blood 2022; 139 (16): ... Hemostasis TO THE EDITOR: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening form of thrombotic ... Joly BS, Coppo P, Veyradier A. Thrombotic thrombocytopenic purpura. Blood. 2017;129(21):2836-2846.Google ScholarCrossrefSearch ...
Tópico(s): Platelet Disorders and Treatments
2022 - Elsevier BV | Blood
Sir G. Lefevre, J. O. M'William, Dr. J. B. Williams, G. Burrows, Alex. Fleming, S. Gower, Dr. C. J. B. Williams, A. Ross, Mr. James W. Ilott, C. J. B. Williams, C. J. B. Williams, O'B. Bellingham, David MacLagan, E. L. Ormerod, James Turnbull, Dr. Julius Vögel, Mr. W. S. Kirkes, M. Nathalis Guillot, A. Makellar, J. H. Toswell, E. B. Sheriffs, George Burrows, Robert Dick, J. Aldridge, J. F. Duncan, J. B. Wilmott, R. J. Graves, Golding Bird, R. H. Allnatt, Golding Bird, E. J. Shearman, H. Kennedy, C. J. B. Williams, C. J. B. Williams, Dr. Julius Vögel, Mr. W. S. Kirkes, G. Badley, J. Hicks, Mr. Thomas Taylor, E. Bishop, H. Letheby, Robert Barnes, J. M. Neligan, John Hogg, John Higginbottom, J. Moore Neligan, J. S. Wilkinson, Golding Bird, M. Ballard, Wm. Fergusson, R. O'Shaughnessy, William Fergusson, Joseph Pancoast, R. Adams, Bransby B. Cooper, Bransby B. Cooper, D. Gilbert, Mr. G. N. Epps, M. Gendrin, J. Luke, Norman Chevers, George W. Campbell, William Craig, J. M. O'Ferrall, Bransby B. Cooper, T. P. Teal, J. C. Christopher, R. S. Davis, John Hamilton, Edward Cock, W. Lawrence, W. Chapman, James Duncan, W. Lawrence, C. W. Stearns, Bransby B. Cooper, J. M. Arnott, S. J. Jeaffreson, Dr. A. Brigham, J. J. Scallan, James Syme, C. Aston Key, Bransby B. Cooper, James Syme, James Duncan, W. Colles, J. P. M'Donald, Benjamin Phillips, M. Leroy D'Etiolles, Isaac Harrinson, F. Le Gros Clark, D. O. Edwards, W. Lawrence, W. R. Wilde, P. W. MacLagan, John Topham, James Jago, M. Brefeld, W. R. Beaumont, W. R. Wilde, R. Graves, R. W. Tamplin, C. Aston Key, J. R. Barton, W. B. Kesteven, G. Southam, H. J. Johnson, John Chippendale, T. G. Geoghegan, A. T. Thomson, Robert Lee, Richard Doherty, John Goodsir, J. H. Bennett, E. W. Murphy, James Syme, Wm. Jackson, J. C. W. Lever, W. Tyler Smith, J. Aldridge, Edward Rigby, Thos. Williamson, Richard Doherty,
... Surgeon to the Royal Orthopœdic Hospital, Treatment of Purpura Hæmorrhagica, by Turpentine.—By J. M. Neligan, Esq., ... Surgery, in King's College, London, Treatment of Purpura Hæmorrhagica by Lead.—By John Hogg, Esq., M. ...
1845 - Gale Group | NCCO-STM 1of2
Bogac Ercig, Tom Arfman, Johana Hrdinová, Kanin Wichapong, Chris Reutelingsperger, Karen Vanhoorelbeke, Gerry A. F. Nicolaes, Jan Voorberg,
... circulation. In patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP), a rare life-threatening disease, ADAMTS13 is ... circulation. In patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP), a rare life-threatening disease, ADAMTS13 is ... relates to the onset of autoimmune thrombotic thrombocytopenic purpura (TTP). TTP is a rare and life-threatening ... S. Lämmle B. Cataland S.R. Thrombotic thrombocytopenic purpura: Pathophysiology, diagnosis, and management.J. Clin. Med. 2021; ...
Tópico(s): Platelet Disorders and Treatments
2021 - Elsevier BV | Journal of Biological Chemistry
W. Cluley, Golding Bird, John Hogg, A. Ross, J. Sebastian Wilkinson, John Moore,
... of the Eustachian Tube, Mesmerism—Clairvoyance, Case of Purpura Hæmorrhagica Successfully Treated by Lead, On the Treatment ... On the Use of Ergot of Rye in Purpura Hæmorrhagica and Some Other Diseases, Case of Tetanus, ...
1845 - Gale Group | NCCO-STM 1of2
X. Long Zheng, Sara K. Vesely, Spero R. Cataland, Paul Coppo, Brian Geldziler, Alfonso Iorio, Masanori Matsumoto, Reem A. Mustafa, Menaka Pai, Gail Rock, Lene Russell, Rawan Tarawneh, Julie Valdes, Flora Peyvandi,
... good clinical care of patients with thrombotic thrombocytopenic purpura (TTP). The "GPSs" are not evidence‐based recommendations. ... plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group.N Engl J Med. ... T.S. Improved Improved survival in thrombotic thrombocytopenic purpura‐hemolytic uremic syndrome. Clinical experience in 108 patients. ... in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.Blood. 2004; 103: 4043-4049Crossref PubMed Scopus (382) ...
Tópico(s): Platelet Disorders and Treatments
2020 - Elsevier BV | Journal of Thrombosis and Haemostasis
James O'Beirne, Meredith Gairdner, William Wallace, P. Ch. A. Louis, G. Andral, Robert Lee, M. Le Baron Dupuytren, Herbert Mayo, Benjamin Phillips, B. G. Babington, Mr. J. Perry, A. B. Granville, J. Cruveilhier, Robert Carswell, Dr. D. Davis, Denis Phelan, James Russell, M. Dance, John Stirling,
... the Arch, or Curve of the Aorta, Fatal Purpura Hæmorrhagical Petechle in the Brain, Heart, Lungs, &c., ... an Eruption of Ecthyma Cachecticum, The Pathology of Purpura, Obliteration of the Uterine Veins after the Puerperal ...
1833 - Gale Group | NCCO-STM 1of2
... of patients. This statement applies for thrombotic thrombocytopenia purpura (TTP) in the setting of pregnancy. As we ... on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies.J Thromb Haemost. 2017; ... thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross‐sectional analysis of the French national ... on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies.J Thromb Haemost. 2017; ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2020 - Elsevier BV | Journal of Thrombosis and Haemostasis
Arthur Van Harlingen, James Nevins Hyde, Robert Campbell, L. Duncan Bulkley, F. L. Keyes, A. R. Robinson, L. Duncan Bulkley, F. P. Kinnicutt, Robert Abbe, Dr. P. A. Morrow, Dr. F. P. Foster, Edward B. Bronson, Robert Campbell, Geo. Henry Fox, Edward Wigglesworth, George H. Rohè, James Nevins Hyde, Louis A. Duhring,
... Chronic, Squamous, Pruriginous and Pustular, Case of Iodic Purpura. By Robert Abbe, M. D., New York, Multiple ... Skin Diseases. Part III. Eczema (Squamosum), Syphiloderm (Erythematosum), Purpura (Simplex), …. Display ads: Lectures on Dermatology, Cincinnati Lancet ...
1878 - Gale Group | NCCO-STM 1of2
Theodora K. Karagounis, Katharina S. Shaw, Avrom S. Caplan, Kristen Lo Sicco, Alisa N. Femia,
... has been increasingly scrutinized, including that of retiform purpura. Additionally, an increased incidence of thromboembolism has been ... COVID-19,1 and histopathologic evaluation of retiform purpura in COVID-19 patients demonstrated thrombotic vasculopathy suggestive of a hypercoagulable state.2 To better characterize purpura and necrotic ulcerations in hospitalized COVID-19 patients ... syndrome coronavirus polymerase chain reaction) and presence of purpura and/or necrotic ulceration. Salient laboratory values and ...
Tópico(s): Parvovirus B19 Infection Studies
2020 - Wiley | International Journal of Dermatology
W. Frank Haehnlen, John V. Shoemaker, Frank Woodbury, Benjamin T. Shimwell, Elias Wildman,
... the Ear, Therapeutic Notes, Croupous Pneumonia Complicated with Purpura Hæmorrhagica, Hepatic Neuralgia, The Treatment of Bronchial or ... Medical News and Miscellany, Unopposed Practice for Sale, Purpura Simplex as an Infectious Disease, The Medical Reader ...
1893 - Gale Group | NCCO-STM 1of2
Damien Contou, Rémi Coudroy, Gwenhaël Colin, Jean-Marc Tadié, Martin Cour, Romain Sonneville, Armand Mekontso Dessap, Nicolas de Prost,
... main cause of overwhelming post-splenectomy infections, and purpura fulminans may develop in almost 20% of patients ... to the intensive care unit (ICU) for pneumococcal purpura fulminans. Methods A 17-year national multicenter retrospective ... admitted to 55 French ICUs for an infectious purpura fulminans from 2000 to 2016. Patients with pneumococcal purpura fulminans were analyzed according to the absence or ... the 306 patients admitted to the ICU for purpura fulminans, 67 (22%) had a pneumococcal purpura fulminans, ...
Tópico(s): Trauma and Emergency Care Studies
2020 - BioMed Central | Critical Care
J. A. Paris, M. L. Rostan, Le Docteur Louis Valentin, Benjamin Travers, Leonard Koecker, M. Andral, M. Louis, John Lizars, W. MacKenzie, D. Barry,
... Glasgow Regulations Medicine, Drs. Hawkins and Chambers on Purpura Hæmorrhagica, Fever, Fracture of the Neck of the ... Medico-Chirurgical Society of Edinburgh A Case of Purpura Hœmorrhagica Terminating Fatally, with the Appearances on Dissection, ...
1827 - Gale Group | NCCO-STM 1of2
Marcus SR Dickey, Anant Raina, Peter J Gilbar, Brendan Wisniowski, Joel Collins, Bhaskar Karki, Andrew Nguyen,
... next day and, after detailed investigations, thrombotic thrombocytopenic purpura was diagnosed. Management and outcome Pembrolizumab was immediately ... and haemolytic anaemia resolved. Discussion Acquired thrombotic thrombocytopenic purpura is an autoimmune disorder caused by an inhibitory ... 13. While most cases of acquired thrombotic thrombocytopenic purpura are idiopathic, certain conditions (e.g. bacterial infection, ... malignancies) and medications are associated with thrombotic thrombocytopenic purpura. Other potential causes were eliminated in our patient. ...
Tópico(s): Immune Cell Function and Interaction
2019 - SAGE Publishing | Journal of Oncology Pharmacy Practice
L. Webster Fox, Edwin J. Houston, Edwin Rosenthal, Wilbur W. Bulette, J. E. Allaben, J. M. Deam, A. W. Davidson,
... Complicated from the Beginning with Very Serious Infectious Purpura. Letter to the editor: Correspondence Listerine in Versicolor, ...
1894 - Gale Group | NCCO-STM 1of2
Qin Zhang, Qi Guo, Guo‐li Ming, Zhenhua Ren, Bo Hu, Ling Lü, Fang Deng,
Henoch-Schönlein purpura is a common small vessel vasculitis in children. Acute pancreatitis rarely presents as a complication of Henoch-Schönlein purpura and has not been well characterized. We retrospectively reviewed 13 cases of Henoch-Schönlein purpura with acute pancreatitis among 3212 patients who attended ... abdominal ultrasonography. Although all patients had typical skin purpura (13/13), 5 patients (5/13) with acute ... abdominal pain in clinical onset of Henoch-Schönlein purpura. Glucocorticoid therapy was effective in alleviating abdominal symptoms ...
Tópico(s): Pancreatitis Pathology and Treatment
2018 - BioMed Central | BMC Pediatrics
Wm. J. Johnson, H. V. Wooten, James F. Duncan, Samuel S. Purple, George Budd, Robert Liston, Thomas H. Mutter, N. S. Davis, Jas. C. Ayer,
... Therapeutical Action of the Aconitum Napellus, Turpentine in Purpura Hemorrhagica, On Headache, Accompanied by Alkaline Urine, Nitrate ...
1846 - Gale Group | NCCO-STM 1of2
Upendra Katneni, Juan C. Ibla, Ryan Hunt, Tal Schiller, Chava Kimchi‐Sarfaty,
... abnormality is the congenital form of thrombotic thrombocytopenic purpura (TTP) resulting from germline mutations in the ADAMTS‐ ... abnormality is the congenital form of thrombotic thrombocytopenic purpura (TTP) resulting from germline mutations in the ADAMTS‐ ... of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.Nature. 2001; 413: 488-94Crossref PubMed Scopus (1436) ... protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura.J Biol Chem. 2001; 276: 41059-63Abstract Full ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2018 - Elsevier BV | Journal of Thrombosis and Haemostasis
Irving M. Snow, F. H. Stephenson, Gregory Doyle, S. L. Elsner, George M. Palmer, Alfred E. Diehl, F. G. Moehlau, Franklin C. Gram, Mahlon Bainbridge Folwell, Byron H. Daggett, Maud J. Frye, Franklin C. Gram, Thomas Hunt Stucky, Arthur G. Bennett, Richard H. Satterlee, Louis A. Duhring, Frederick Treves, James B. Herrick, Georges Hayem, Dr. Otto Roth, Michael Foster, Alfred L. Loomis, William E. Anthony, E. C. Adams,
... of Peliosis to the Other Forms of Idiopathic Purpura, Topics of the Month, Modern Materia Medica with ...
1896 - Gale Group | NCCO-STM 1of2
Élie Azoulay, Paul Knoebl, José Garnacho‐Montero, Kateřina Rusínová, Gennadii M. Galstian, Philippe Eggimann, Fekri Abroug, Dominique Benoît, Michael von Bergwelt‐Baildon, Julia Wendon, Marie Scully,
... uremic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP) and other causes or conditions with thrombotic ... uremic syndrome (aHUS) presents similarly to thrombotic thrombocytopenic purpura (TTP) and other causes or conditions with thrombotic ... include hemolytic uremic syndromes (HUSs) and thrombotic thrombocytopenic purpura (TTP), and a number of differential diagnoses that ... P.M. Understanding organ dysfunction in thrombotic thrombocytopenic purpura.Intensive Care Med. 2015; 41: 715-718Crossref PubMed ...
Tópico(s): Hemoglobinopathies and Related Disorders
2017 - Elsevier BV | CHEST Journal
Professor A. T. Thomson, Dr. J. Begbie, Dr. C. Carlyon, Dr. H. M. Hughes, Horace Nelson, Horace Nelson, Horace Nelson,
... State, after the Disease, Disease Generally, Nitre in Purpura Hæmorrhagia, Popular Essays on Anatomy and Physiology Ligaments ...
1850 - Gale Group | NCCO-STM 1of2
Damien Noone, Magdalena Riedl, Fred G. Pluthero, Mackenzie Bowman, M. Kathryn Liszewski, Lily Lu, Yi Quan, Steve Balgobin, Reinhard Schneppenheim, Sonja Schneppenheim, Ulrich Budde, Paula James, John P. Atkinson, Nades Palaniyar, Walter H.A. Kahr, Christoph Licht,
Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects ... Willebrand factor (VWF)-multimers arise in thrombotic thrombocytopenic purpura. However, recent studies suggest that both entities are ... injury. Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in ...
Tópico(s): Renal Diseases and Glomerulopathies
2016 - Elsevier BV | Kidney International
Harriet C. Hinds, Harriet C. Hinds, William Tod Helmuth, J. P. Nolan, R. A. Toms, William J. Krausi, O. A. Hyde, Arthur R. Tiel, G. W. Boskowitz, Hans Harris, John W. Fyfe, A. W. Smith, I. E. Layton, Mrs. E. Lee, Dr. Ethyl H. Richardson, Wm. Collins Hatch, Pitts Edwin Howes, Mariette G. McGinnis, Dr. C. S. Webster, Gustav Bruehl, Harvey W. Felter, Herbert T. Webster, William Nelson Mundy,
... of a Grain Doses, Produces Good Results in Purpura Hemorrhagica, The Ladies' Auxiliary of the National Eclectic ...
1902 - Gale Group | NCCO-STM 1of2
Éric Mariotte, Élie Azoulay, Lionel Galicier, Eric Rondeau, Fouzia Zouiti, Pierre Boisseau, Pascale Poullin, Emmanuel de Maistre, François Provôt, Yahsou Delmas, Pierre Perez, Y. Benhamou, Alain Stépanian, Paul Coppo, Agnès Veyradier,
Background Thrombotic thrombocytopenic purpura is a thrombotic microangiopathy related to a severe deficiency of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 ... and the epidemiology and pathophysiology of thrombotic thrombocytopenic purpura at initial presentation. Methods Between Jan 1, 1999, ... identify variables significantly associated with idiopathic thrombotic thrombocytopenic purpura, as measured by estimated odds ratios (ORs) and ... enrolled 939 patients with adult-onset thrombotic thrombocytopenic purpura, of whom 772 (82%) patients had available data ...
Tópico(s): Renal Diseases and Glomerulopathies
2016 - Elsevier BV | The Lancet Haematology
M. Cullerier, James Mease, Geo. Frost, Leonard M'Phail, M. Leonardon, M. Lisfranc,
... On Stings and Bites of Insects, King on Purpura Hæmorrhagica, Ulcerated Bubo Treated by Chalybeates, Gray Sulphur ...
1837 - Gale Group | NCCO-STM 1of2
Bérangère S. Joly, Alain Stépanian, Thierry Leblanc, David Hajage, Hérvè Chambost, Jérôme Harambat, Fanny Fouyssac, Vincent Guigonis, Guy Leverger, Tim Ulinski, Thérèsa Kwon, Chantal Loirat, Paul Coppo, Agnès Veyradier,
Background Thrombotic thrombocytopenic purpura is a rare thrombotic microangiopathy, related to a severe ADAMTS13 deficiency (a disintegrin and metalloprotease with thromboSpondin type 1 ... activity <10% of normal). Childhood-onset thrombotic thrombocytopenic purpura is very rare and initially often misdiagnosed, especially ... presentation, management, and outcome of acquired thrombotic thrombocytopenic purpura in children. Methods Between Jan 1, 2000, and ... child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura included in the French national registry for thrombotic ...
Tópico(s): Platelet Disorders and Treatments
2016 - Elsevier BV | The Lancet Haematology
John P. Harrison, C. T. Wilson,
... Wilson, M. D., of Leesville, Ia., Turpentine in Purpura Hœmorrhagica, Pathology and Practical Medicine Report on the ...
1846 - Gale Group | NCCO-STM 1of2