Produção Nacional
Revisado por pares
Caroline D. Souza-Tarla, Juliana A. Uzuelli, Alcyone Artioli Machado, Raquel F. Gerlach, José E. Tanus‐Santos,
... and the gelatinolytic activities of plasma matrix metalloproteinase (pMMP)-2 and pMMP-9, and the influences of plasma storage temperature, ... 70°C until assayed for gelatin zymography of pMMP-2 and pMMP-9. The effects of food intake, repeated freeze– ... cycles had no effect on the activities of pMMPs (all P < 0.05). A linear relationship was ... Different volumes of plasma should be studied when pMMP-2 and pMMP-9 activities are studied. Storage temperature, repeated freeze– ... food intake do not affect the activities of pMMPs.
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2005 - Elsevier BV | Clinical Biochemistry
Huiyan Zeng, Harold F. Dvorak, Debabrata Mukhopadhyay,
... receptor fragments were then subcloned into retroviral vector pMMP (kindly provided by Dr. Richard A. Mulligan) to ... enzymes. The EGLT was subcloned to retroviral vector pMMP to express protein in HUVECs. The EGLT(793stop) ... Dr. Alex Toker) were subcloned to retroviral vector pMMP to express protein in HUVECs. To prepare the ... h before transfection. 20 µg of targeted genes (pMMP-EGDR, pMMP-EGLT, or pMMP-LacZ, etc.), 15 µg of pMD.MLV gag. ... transduced into HUVECs with a retroviral expression vector (pMMP). Cells transduced with chimeric receptors or with LacZ ...
Tópico(s): Coronary Interventions and Diagnostics
2001 - Elsevier BV | Journal of Biological Chemistry
Tülay Köken, Fatih Gürsoy, Ahmet Kahraman,
... we evaluated the relationship between pro MMP-9 (pMMP-9) and oxidative stress in plasma of rat ... AST), tumor necrosis factor-α (TNF-α) and pMMP-9 levels were measured. Chronic ethanol administration increased the AST, MDA, PCs, TNF-α and pMMP-9 levels when compared to those in control ... p < 0.01, respectively). Also TNF-α and pMMP-9 levels returned to normal by vitamin E ... Within all subjects, there was positive correlation between pMMP-9 levels and MDA, PCs levels (p = 0. ... that since antioxidant supplementation decreases the alcohol-induced pMMP-9 levels, oxidative stress could be one of ...
Tópico(s): Redox biology and oxidative stress
2010 - Springer Science+Business Media | Journal of Medical Toxicology
Fatima Zahra Mokkedem, Xianlong Fu,
... Mokkedem Department of Mathematics, Shanghai Key Laboratory of PMMP, East China Normal University, Shanghai, 200241 China Department ... cn. Department of Mathematics, Shanghai Key Laboratory of PMMP, East China Normal University, Shanghai, 200241 China Correspondence ... Fu, Department of Mathematics, Shanghai Key Laboratory of PMMP, East China Normal University, Shanghai 200241, China. E- ... Mokkedem Department of Mathematics, Shanghai Key Laboratory of PMMP, East China Normal University, Shanghai, 200241 China Department ...
Tópico(s): Differential Equations and Numerical Methods
2016 - Wiley | International Journal of Robust and Nonlinear Control
Zubin Master, Jennifer M. Tran, Aseem Bishnoi, Stephen H. Chen, John M.L. Ebos, Paul Van Slyke, Robert S. Kerbel, Daniel Dumont,
... mediated interaction and that this binding requires a PMMP motif in the proline-rich tail of Dok- ... mediated interaction and that this binding requires a PMMP motif in the proline-rich tail of Dok- ... Abl via its SH3 domain, which requires a PMMP motif on Dok-R. In addition, we demonstrate ... domain can associate with Dok-R through its PMMP motif, we performed several in vitro binding experiments ... R (Fig. 2E). Participation of the Dok-R PMMP motif in associating c-Abl was further illustrated ...
Tópico(s): Melanoma and MAPK Pathways
2003 - Elsevier BV | Journal of Biological Chemistry
Martyn LEES, D. Taylor, David E. Woolley,
... and chymase, respectively, it was demonstrated that both pMMP‐1 and pMMP‐3 were effectively processed and activated by the chymase component. By contrast, tryptase activated only pMMP‐3. The mast cell proteinases were unable to ... by mast cell proteinases was shown to activate pMMP‐9, but not pMMP‐2. Since we have no evidence that mast ...
Tópico(s): Protease and Inhibitor Mechanisms
1994 - Wiley | European Journal of Biochemistry
Javier Puente, Maria Paz Jaque, Carolina Carrasco, C.Y. Cruz, María Teresa Valenzuela, Marion E. Wolf, Aron D. Mosnaim,
... in vitro secretion of pro‐matrix metalloproteinase‐9 (pMMP‐9) from whole blood and purified neutrophils samples. ... zone at MW 92 kD indicated presence of pMMP‐9. Area of proteolysis was estimated by densitometry; prestained standards were used to assess pMMP‐9 molecular weight. Results.— Peripheral blood mononuclear cell' ... 9 secretion by whole blood samples. However, basal pMMP‐9 secretion by purified neutrophil preparations was significantly ... of NKC activity and direct inhibition of neutrophils pMMP‐9 secretion. These results suggest that they may ...
Tópico(s): Hemostasis and retained surgical items
2008 - Wiley | Headache The Journal of Head and Face Pain
Tie-Nian Zhu, Hua‐Jun He, Sutapa Kole, Theresa D’Souza, Rachana Agarwal, Patrice J. Morin, Michel Bernier,
... stably reintroduced. Using an MMP-9 promoter construct (pMMP-9-Luc), in vitro kinase assays, and genetic ... demonstrate that FLNa mediated transcriptional down-regulation of pMMP-9-Luc by suppressing the constitutive hyperactivity of ... stably reintroduced. Using an MMP-9 promoter construct (pMMP-9-Luc), in vitro kinase assays, and genetic ... demonstrate that FLNa mediated transcriptional down-regulation of pMMP-9-Luc by suppressing the constitutive hyperactivity of ... the MEK inhibitor U0126, PMA-mediated increases in pMMP-9-Luc activity felt sharply upon inhibition of ...
Tópico(s): Signaling Pathways in Disease
2007 - Elsevier BV | Journal of Biological Chemistry
Shailender Gugalavath, Kiranmayi Patanla, Rama Rao Malla,
... MMP-2 at 10 Gy. Plasmid MMP-2shRNA (pMMP-2) reduced the IR (10 Gy) induced cytotoxicity ... by PI stain and annexin V assay, respectively. pMMP-2 also modulates the expression of EGFR and ... expression of survival protein, Bcl-2. In contrary pMMP-2 decreased the LDH activity, survival fraction and ... cyclinB as well as CDK1.Results conclude that pMMP-2 protected HDFs from IR and sensitized the MCF-7 cells. Therefore, pMMP-2 can be employed for better treatment of ...
Tópico(s): Retinoids in leukemia and cellular processes
2019 - Wiley | Journal of Cellular Biochemistry
Eriko Koyama, Dong‐Ryul Sohn, S. G. Shin, Kazuhiro Chiba, Jae‐Gook Shin, Yang Hee Kim, H Echizen, Takashi Ishizaki,
... of metoprolol but PMs of S-mephenytoin (EMML/PMMP) and seven subjects were EMs of both metoprolol ... in the PMML/EMMP group and the EMML/PMMP group than in the EMML/EMMP group, although ... P < .05) was found only in the EMML/PMMP vs. the EMML/EMMP group. The mean area ... 6 times smaller (P < .05) in the EMML/PMMP group than in the EMML/EMMP group. The ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
1994 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
... key to link predictive mapping of mineral prospectivity (PMMP) and quantitative mineral resource assessment (QMRA). This proposition is demonstrated by PMMP for hydrothermal Au‐Cu deposits (HACD) and by ... results of the study support the proposition that PMMP can be a part of QMRA if the ... the deposit‐type sought is considered in both PMMP and QMRA.
Tópico(s): Mineral Processing and Grinding
2010 - Wiley | Resource Geology
Amitava Das, Martín E. Fernández-Zapico, Sheng Cao, Janet Yao, Stefano Fiorucci, Robert P. Hebbel, Raúl Urrutia, Vijay H. Shah,
... and lacZ were subcloned into the retroviral vector pMMP using standard molecular approaches to generate pMMP-rFXR, pMMP-rSHP, and pMMP-rLacZ (30Zeng H. Sanyal S. Mukhopadhyay D. J. ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2006 - Elsevier BV | Journal of Biological Chemistry
Michael A. Pulsipher, Gary M. Kupfer, Dieter Näf, Ahmed Suliman, Jeng-Shin Lee, Petra Jakobs, Markus Grompe, Hans Joenje, Colin A. Sieff, Eva C. Guinan, Richard C. Mulligan, Alan D. D’Andrea,
... and FAC for transduction of FA cell lines (pMMP-FAA and pMMP-FAC). The pMMP-FAA construct specifically complemented the abnormal phenotype of cell lines from FA-A patients, while pMMP-FAC complemented FA-C cells. In summary, the ...
Tópico(s): Chromosomal and Genetic Variations
1998 - BioMed Central | Molecular Medicine
Xiaoyan Zhou, Lanqin Xu, Jiake Xu, Jianping Wu, T.B. Kirk, Dong Ma, Wei Xue,
... doxorubicin, DOX) and gene (MMP-9 shRNA plasmid, pMMP-9) delivery ability in vivo, and their cellular ... were investigated. Particularly, PCL-HPG-PEI600 showed excellent pMMP-9 delivery ability with significantly higher transfection efficiency ... co-delivery system of PCL-HPG-PEI600/DOX/pMMP-9 resulted in a much better inhibition effect ... vivo compared to those of single DOX or pMMP-9 formulation used. Moreover, PCL-HPG-PEI600 displayed ...
Tópico(s): Nanoparticle-Based Drug Delivery
2018 - American Chemical Society | ACS Applied Materials & Interfaces
Yan Zhou, Ramaraja P. Ramasamy,
... In this study, bacteriophage P100-modified magnetic particles (PMMPs) were developed for the separation of L. monocytogenes ... phage was investigated, and the performance of each PMMP complex was evaluated by their L. monocytogenes capture ... to the chemical immobilization method, the physically immobilized PMMP complex achieved a higher capture efficiency initially, with excellent selectivity towards target bacteria. The PMMPs were further tested for selective isolation of L. ...
Tópico(s): Bacteriophages and microbial interactions
2018 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Tao Liu, Xidong Wu, Shaohua Chen, Peina Wu, Hong Han, Hongbin Zhang, Junzheng Li, Guanxue Li, Siyi Zhang,
... polymeric prodrug could deliver MMP-9 shRNA plasmid (pMMP-9) again to form the drug and gene co-delivery system of Tf-PAAs-MTX/pMMP-9. The co-delivery system showed the effective ... MTX. Benefiting from the sensibilization effect and MTX/pMMP-9 co-delivery strategy, this Tf-PAAs-MTX/pMMP-9 co-delivery system exhibited the significantly improved ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2019 - Taylor & Francis | Drug Delivery
Xiangpei Gu, Zhuoran Zhang, Linnan Sun, Li Yu,
... APHEG consists of a permanent magnet machine part (PMMP), a flux modulation machine part (FMMP), and a ... FMMP field at the expense of weakening the PMMP field. By taking advantage of that, the combination of the PMMP and FMMP can effectively boost the output power ... voltage-boost region as the weakening of the PMMP field is negligible. In addition, the magnetic field ...
Tópico(s): Magnetic Properties and Applications
2020 - IEEE Magnetics Society | IEEE Transactions on Magnetics
Boxuan Ma, Hong Xu, Yanan Wang, Li Yang, Weihua Zhuang, Gaocan Li, Yunbing Wang,
... MEMA-co-PDMA)] to self-assemble into LFP@PMMP micelles. LFP@PMMP can be further coated with red blood cell ( ... membrane to obtain surface-biomimetic nanoparticles (RBC/LFP@PMMP), demonstrating prolonged circulation, minimal drug leakage, and better ... at the plaques. With ROS responsiveness, RBC/LFP@PMMP can be interrupted at inflammatory atherosclerotic tissue with ...
Tópico(s): Lipid Membrane Structure and Behavior
2021 - American Chemical Society | ACS Applied Materials & Interfaces
Soo‐Jin Sohn, Young‐Mi Min, June‐Yi Lee, Chi‐Yung Tam, In‐Sik Kang, Bin Wang, Joong‐Bae Ahn, Toshio Yamagata,
The performance of the probabilistic multimodel prediction (PMMP) system of the APEC Climate Center (APCC) in predicting the Asian summer monsoon (ASM) precipitation at a four‐month lead (with February initial ... and disadvantages in both forecast systems. First, the PMMP appears to have higher skills for both above‐ ... validated statistical skill may be overestimated. Second, the PMMP is the better tool for capturing atypical ENSO ( ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2011 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Akihiro Ohashi, Małgorzata Z. Zdzienicka, Junjie Chen, Fergus J. Couch,
... Toshiyasu Taniguchi kindly provided FA-D1 cells (VU423/PMMP), FA-D1 cells stably expressing BRCA2 (A913 423/ ... cells also received 1 μg/ml puromycin. VU423/PMMP cells were cultured in Dulbecco's modified Eagle' ... BRCA2 using BRCA2 mutant FA-D1 cells (VU423/PMMP) cells. Following MMC or IR treatment, the percentage ...
Tópico(s): CRISPR and Genetic Engineering
2005 - Elsevier BV | Journal of Biological Chemistry
Michiel S. van der Heijden, Jonathan R. Brody, Eike Gallmeier, Steven C. Cunningham, David A. Dezentjé, Dong Shen, Ralph H. Hruban, Scott E. Kern,
... with separately prepared lysates. The retroviral expression vectors pMMP-puro,15Ory DS Neugeboren BA Mulligan RC A ... 93: 11400-11406Crossref PubMed Scopus (807) Google Scholar pMMP-puroFANCC,16Garcia-Higuera I Kuang Y Naf D ... 4866-4873Crossref PubMed Scopus (200) Google Scholar and pMMP-puroFANCG17Kuang Y Garcia-Higuera I Moran A Mondoux ...
Tópico(s): Acute Lymphoblastic Leukemia research
2004 - Elsevier BV | American Journal Of Pathology
Partial Mueller matrix polarimeters (pMMPs) are active sensing instruments that probe a scattering process with a set of polarization states and analyze the scattered light ... of polarization states. Unlike conventional Mueller matrix polarimeters, pMMPs do not attempt to reconstruct the entire Mueller ... In the process, we identify 10 classes of pMMP systems, for which the space coverage is immediately ...
Tópico(s): Surface Roughness and Optical Measurements
2015 - Optica Publishing Group | Journal of the Optical Society of America A
Qianming Lin, Yumeng Yang, Hu‐Jun Qian, Zhong Guo, Tao Liu, Jiake Xu, Jianping Wu, T.B. Kirk, Dong Ma, Wei Xue,
... optimized condition. After gelation, MMP-9 shRNA plasmid (pMMP-9) could be encapsulated into the hydrogel matrix ... α-CD content. The released MPEG-PLLD-Arg/pMMP-9 complex still showed better transfection efficiency than ... apoptosis. Also, in vivo assays indicated that this pMMP-9-loaded supramolecular hydrogel could result in the ...
Tópico(s): RNA Interference and Gene Delivery
2016 - Elsevier BV | Acta Biomaterialia
Chu-Ya Huang, Phung-Anh Alex Nguyen, Daniel L. Clinciu, Chun-Kung Hsu, Jui-Chia Richard Lu, Hsuan‐Chia Yang, Chieh-Chen Wu, Wen‐Chen Tsai, Yueh‐Ching Chou, Terry B. J. Kuo, Polun Chang, Wen‐Shan Jian, Yu‐Chuan Li,
... the effectiveness of a personalized medication management platform (PMMP) for improving medication adherence, self-management medication, and ... long-term medication costs. We developed a mobile PMMP to reduce delayed and missed medications. A randomized ...
Tópico(s): Pharmaceutical studies and practices
2016 - Elsevier BV | Computer Methods and Programs in Biomedicine
Chao Sun, Xiongxiong Liu, Cuixia Di, Zhenhua Wang, Xiangquan Mi, Liu Yang, Qiuyue Zhao, Aihong Mao, Wei‐Qiang Chen, Lu Gan, Hong Zhang,
... and decreased oxygen consumption. Therefore, a pseudo-MMP (PMMP) was formed via maintenance of exogenous positive charges. ... macroautophagy/autophagy. Therefore, we conclude that MitoQ increases PMMP via proton displacement with exogenous positive charges. In addition, PMMP triggered autophagy in hepatocellular carcinoma HepG2 cells via ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2017 - Taylor & Francis | Autophagy
Tao Liu, Jingzhen Li, Xidong Wu, Siyi Zhang, Zhongming Lu, Guanxue Li, Junzheng Li, Shaohua Chen,
... deliver docetaxel (DOC) and MMP-9 shRNA plasmid (pMMP-9) effectively and showed the targeting effect to ... DOC. Benefiting from the sensibilization effect and DOC/pMMP-9 co-delivery strategy, this Tf-HPAA-GO/DOC/pMMP-9 co-delivery system exhibited the significantly improved ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2019 - Taylor & Francis | Drug Delivery
Xingting Bao, Xiongxiong Liu, Qing-Feng Wu, Fei Ye, Zheng Shi, Dan Xu, Jinhua Zhang, Zhihui Dou, Guomin Huang, Hong Zhang, Chao Sun,
... proton production. Therefore, a pseudo-mitochondrial membrane potential (PMMP) was developed via maintenance of exogenous positive charges. This study identified that PMMP constructed by MitoQ could effectively inhibit mitochondrial respiration ... of radiation by utilizing selective autophagy. MitoQ-constructed PMMP provides a new therapeutic strategy for specific radiation ...
Tópico(s): ATP Synthase and ATPases Research
2023 - Multidisciplinary Digital Publishing Institute | Antioxidants
Shuai Liu, Mo Zhang, Zhizhen Lai, Hongtao Tian, Yuming Qiu, Zhili Li,
... nanoparticles (Fe3O4-NPs) to form polymer magnetic microparticles (PMMPs). With abundant NHS-activated moieties on their surface, the coral-like PMMPs could be modified by cystamine for the chemoselective ... cost-effective and easy-to-implement preparation of PMMPs with a robust chemoselective extraction ability and versatile ...
Tópico(s): Electrochemical sensors and biosensors
2022 - American Chemical Society | ACS Applied Materials & Interfaces
Chun‐Wen Cheng, Jyh‐Cherng Yu, Hsiao-Wei Wang, Chiun‐Sheng Huang, Jia‐Ching Shieh, Yi‐Ping Fu, Chia‐Wei Chang, Pei‐Ei Wu, Chen‐Yang Shen,
... 20 correlated with patients having poorly differentiated tumors (PMMP-11 = 0.01 and PCK-20 = 0.05) and lymph node metastasis (LNM) (PMMP-11 = 0.004 and PCK-20 = 0.001). ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2009 - Elsevier BV | Clinica Chimica Acta
Huiyan Zeng, Dezheng Zhao, Suping Yang, Kaustubh Datta, Debabrata Mukhopadhyay,
... Valencia, CA). Two μg of each target gene (pMMP-EGDR, pMMP-LacZ, etc.), 1.5 μg of pMD.MLV ...
Tópico(s): Glycosylation and Glycoproteins Research
2003 - Elsevier BV | Journal of Biological Chemistry