Andrew Robson, Simon Barnes Chief Sports Writer, R. H. Foster, Charles Scanlan, Joanna Hunter, Victor Adebowale, Andrew Pierce, DJM, Alexandra Frean, James Moore, Adam Sherwin Media Reporter, S. Rungien, Frances Gibb Legal Editor, Diana Wildman, Carl Mortished European briefing, Robert Thicknesse, Ben MacIntyre Parliamentary Sketch, Tom Bawden, Ingrid Mansell and Neelam Verjee, Caroline Brannigan, Ian Cobain, Hilary Finch, Carol Midgley, David Chater, Nic Hopkins, Helen Gobat, Alexandra Frean Social Affairs Correspondent, Shmuley Boteach, Richard Irving, Rosalind Renshaw, Michael Grade, Roger Maynard, Stewart Tendler, Crime Correspondent, Felicity Collier, Joe Joseph, David Sharrock, Ben Webster Transport Correspondent, David McVay, Angus MacLeod Scottish Political Correspondent, Jeremy Rice, Tim Reid, Richard Ford Home Correspondent, Philip Webster and Richard Beeston, Alan Hamilton, Helen Dunmore, Gary Duncan and Nick Hasell, Roland Watson, Richard Lloyd Parry, Matt Dickinson Chief Football Correspondent, David Jones, Mark Court, David Lister Ireland Correspondent and Melissa Kite, Caroline Merrell Banking Correspondent, Jilly Cooper, Angela Jameson, Simon Tait, Steven Norris, Paula Hawkins, Russell Kempson, Vanora Bennett, Daniel McGrory, Tony Halpin Education Editor, Oliver Kay, Jerome Burne, Mark Atherton, Lisa Armstrong, Rick Broadbent, Ann Treneman, Sydney Perera, Simon de Bruxelles, Karen Homer, Rob Wright, Geoffrey Dean, Alison Roberts, David Gilmour, Keith B. Pearson, J. W. Pomeroy (Civil Servant), Neil Harman Tennis Correspondent, Martin Samuel, Raymond Keene, Adam Sage, Lewis Smith, Peter Riddell Political Briefing, Ren Pierce, R. F. Jameson, Greg Hurst Parliamentary Correspondent, Bronwen Maddox, Russell Hotten, Clem Cecil, Richard Willan, S. E. Giddings, Nick Hasell, Tony Woolrich, Edward Bailey, Thomas Axmacher, David Hands Rugby Correspondent, Ruth Scurr, Sam Lister and Helen Studd, M. C. Calder, John Allison, John Goodbody, Patrick Barkham and Simon de Bruxelles, Dominic Kennedy, Mary Ann Sieghart, James Doran, Philip Webster Political Editor, Anne Waite, Tim Clement-Jones, Kevin McCarra, Alain De Botton, ChrisMoran, Allen Kirby, Chris McGrath, George Caulkin, Russell Jenkins, Glen Owen Education Correspondent, Iain Finlayson, Kathleen Richardson, Daniel McGrory and Tim Johnston, Regine Hill, Allen Robertson, Helen Studd and Sam Lister, Bamber Gascoigne, Swami Amono Samarpan, Jack Malvern Arts Reporter, John Naish, Simon Jenkins, Anne Ashworth Personal Finance Editor, Lewis Stuart, Gary Duncan Economics Correspondent, Mark Henderson, Martin Waller, Michael Horsnell, Chris Ayres, Annabelle Thorpe, James Jackson, Alan Coren, Carl Mortished International Business Editor, Sarah Butler, Daniel Rosenthal, Benedict Nightingale, Terence Dowd, Stephen Dalton, James Christopher, Alice Miles, Adam Sherwin, Abigail Rayner, Nicholas Walmsley, BIllie Hunt, David Hobman Director, Alan Lee Racing Correspondent, N. D. Lewis, W. Lastiwka, J. F. Holliday, Patience Wheatcroft, Greg Morse, Christopher Irvine, Lemon Plenta Cake,
... Items Spain Portugal France / Villas & Penthouses / Prime… Parque da Floresta Compton Reeback Overseas Ltd The Times Duquesa - Marbella Villas Agence Baudomaine Torre Mirona Golf & Spa Resort Aristo Developers Gateshead and ...
2002 - Gale Group | TDA
Ana Paço, José Rodrigo da-Silva, Denise Pereira Torres, Bernard R. Glick, Clarisse Brı́gido,
Manganese (Mn) toxicity is a very common soil stress around the world, which is responsible for low soil fertility. This manuscript evaluates the effect of the endophytic bacterium Pseudomonas sp. Q1 on different rhizobial-legume symbioses in the absence and presence of Mn toxicity. Three legume species, Cicer arietinum (chickpea), Trifolium subterraneum (subterranean clover), and Medicago polymorpha (burr medic) were used. To evaluate the role of 1-aminocyclopropane-1-carboxylate (ACC) deaminase produced ...
Tópico(s): Plant-Microbe Interactions and Immunity
2020 - Multidisciplinary Digital Publishing Institute | Plants
Árpád Bényi, Ciprian Demeter, Andrea R. Nahmod, Christoph Thiele, Rodolfo H. Torres, Paco Villarroya,
We prove a T(1) theorem for bilinear singular integral operators (trilinear forms) with a one-dimensional modulation symmetry.
Tópico(s): Mathematical Analysis and Transform Methods
2009 - Springer Science+Business Media | Journal d Analyse Mathématique
Ivelisse Cruz‐Torres, Donald S. Backos, Paco S. Herson,
Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable channel activated by adenosine diphosphate ribose metabolites and oxidative stress. TRPM2 contributes to neuronal injury in the brain caused by stroke and cardiac arrest among other diseases including pain, inflammation, and cancer. However, the lack of specific inhibitors hinders the study of TRPM2 in brain pathophysiology. Here, we present the design of a novel TRPM2 antagonist, tatM2NX, which prevents ligand binding and TRPM2 ...
Tópico(s): Phytochemicals and Antioxidant Activities
2019 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Adriano Camps, F. Torres, I. Corbella, J. Bará, Pedro de Paco,
Antenna pattern mismatches are one of the most important error sources in planned Earth‐observation interferometric radiometers. From a low Earth orbit, the wide field of view, about ±30°, leads to the use of antennas with a large beam. In addition, antennas must be closely spaced to avoid, or at least minimize, aliasing effects in the formation of the synthetic brightness temperature images. The accuracy demanded of these systems requires the precise knowledge of all the antenna radiation voltage ...
Tópico(s): Antenna Design and Optimization
1998 - Wiley | Radio Science
José Ferrão Afonso, Guilhermina Cadeco,
Dois edifícios quinhentistas de Vila do Conde, o Paço do Concelho e a torre sineira da Igreja Matriz, exemplificam dois aspetos importantes da arquitetura ...
Tópico(s): Architecture and Art History Studies
2018 - Catholic University of Portugal | Estudos de Conservação e Restauro
James E. Orfila, Robert M. Dietz, Krista M. Rodgers, Andra Dingman, Olivia P Patsos, Ivelisse Cruz‐Torres, Himmat Grewal, Frank Strnad, Christian Schroeder, Paco S. Herson,
Ischemic stroke is a leading cause of death worldwide and clinical data suggest that children may recover from stroke better than adults; however, supporting experimental data are lacking. We used our novel mouse model of experimental juvenile ischemic stroke (MCAO) to characterize age-specific cognitive dysfunction following ischemia. Juvenile and adult mice subjected to 45-min MCAO, and extracellular field recordings of CA1 neurons were performed to assess hippocampal synaptic plasticity changes ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - SAGE Publishing | Journal of Cerebral Blood Flow & Metabolism
Manuel Barrios-Arpi, J.‐L. Rodríguez Gutiérrez, Bernardo López-Torres,
Summary The histomorphometric features of umbilical cord constituents in seven foetuses of alpaca ( Vicugna pacos ) from Cerro de Pasco, Department, Peru, were determined. Sections of 2–5 cm of umbilical cord were fixed in 10% neutral buffered formalin and processed for light microscopy. Standard histological slides stained with haematoxylin and eosin, Masson's trichrome and Van Gieson's trichrome were obtained. Histologically, common features of umbilical artery and vein were observed as well as mucous ...
Tópico(s): Urological Disorders and Treatments
2017 - Wiley | Anatomia Histologia Embryologia
Adriano Camps, F. Torres, Paco López‐Dekker, Stephen J. Frasier,
The calibration of large antenna arrays in the absence of a beamforming point source is a common problem in beamforming radars and interferometric radiometers. In this paper the fundamentals of the redundant space calibration (RSC) method for phase and amplitude are reviewed, pointing out the parallelism between the active and passive cases, the technique is then applied in a general and systematic way to two cases of interest: hexagonal planar and Y-shaped arrays, which are known to be the optimum ...
Tópico(s): Precipitation Measurement and Analysis
2003 - Taylor & Francis | International Journal of Remote Sensing
José Ferrão Afonso, Guilhermina Cadeco,
Tópico(s): Historical Studies of Medieval Iberia
2018 - Springer Science+Business Media | Electronic Commerce Research
Daniel Benítez‐Ribas, Raquel Cabezón, Georgina Flórez‐Grau, Mari Carmen Molero, Patricia Puerta, Antonio Guillén, Azucena González-Navarro, Sonia Paco, Ángel M. Carcaboso, Vicente Santa‐María López, Ofelia Cruz, Carmen de Torres, Noelia Salvador, Manel Juan, Jaume Mora, Andrés Morales La Madrid,
Background and objective Diffuse intrinsic pontine glioma (DIPG) is a lethal brainstem tumor in children. Dendritic cells (DCs) have T-cell stimulatory capacity and, therefore, potential antitumor activity for disease control. DCs vaccines have been shown to reactivate tumor-specific T cells in both clinical and pre-clinical settings. We designed a phase Ib immunotherapy (IT) clinical trial with the use of autologous dendritic cells (ADCs) pulsed with an allogeneic tumors cell-lines lysate (ATCL) in ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2018 - Frontiers Media | Frontiers in Oncology
Takeru Shimizu, Robert M. Dietz, Ivelisse Cruz‐Torres, Frank Strnad, Ana K. Garske, Myriam Moreno, Venugopal Reddy Venna, Nidia Quillinan, Paco S. Herson,
TRPM2 channels have been suggested to play a role in ischemic neuronal injury, specifically in males. A major hindrance to TRPM2 research has been the lack of specific TRPM2 inhibitors. The current study characterized the specificity and neuroprotective efficacy of a novel TRPM2 inhibitor. Fluorescent calcium imaging (Fluo5F) was used to determine inhibitor efficacy of the TRPM2 peptide inhibitor (tat-M2NX) in HEK293 cells stably expressing hTRPM2. Adult (2–3 months) and aged (18–20 months) mice were ...
Tópico(s): Neuroscience and Neuropharmacology Research
2016 - Elsevier BV | Experimental Neurology
Nidia Quillinan, Guiying Deng, Kaori Shimizu, Ivelisse Cruz‐Torres, Christian Schroeder, Richard J. Traystman, Paco S. Herson,
Cardiac arrest and cardiopulmonary resuscitation (CA/CPR) produce brain ischemia that results in cognitive and motor coordination impairments subsequent to injury of vulnerable populations of neurons, including cerebellar Purkinje neurons. To determine the effects of CA/CPR on plasticity in the cerebellum, we used whole cell recordings from Purkinje neurons to examine long-term depression (LTD) at parallel fiber (PF) synapses. Acute slices were prepared from adult male mice subjected to 8 min cardiac ...
Tópico(s): Vestibular and auditory disorders
2016 - SAGE Publishing | Journal of Cerebral Blood Flow & Metabolism
Elena Sánchez, Sergio Daniel Morales, Laura Paco, Miguel Ángel López‐Nevot, Carmen Hidalgo, J Jiménez-Alonso, Belén Torres, Miguel Á. González‐Gay, José Luis Callejas‐Rubio, Norberto Ortego‐Centeno, J Sánchez-Román, Marı́a-Francisca González-Escribano, Javier Martı́n,
Objective. The aim of this study was to assess the possible association between the interleukin-12B (IL12B) and interleukin-12 receptor beta 1 (IL12RB1) gene polymorphisms with systemic lupus erythematosus (SLE). In addition, we have undertaken a systematic search for genetic variants of interleukin 23 (IL23A).
Tópico(s): Psoriasis: Treatment and Pathogenesis
2005 - Oxford University Press | Lara D. Veeken
Mario Royo-Villanova, Eduardo Miñambres, José Moya Sánchez, Eduardo Torres, C F Manso, M.Á. Ballesteros, G. Parrilla, Gonzalo De Paco Tudela, Elisabeth Coll, Alicia Pérez‐Blanco, Beatriz Domínguez‐Gil,
One concern about the use of normothermic regional perfusion (NRP) in controlled donation after the circulatory determination of death (cDCD) is that the brain may be perfused. We aimed to demonstrate that certain technical maneuvers preclude such brain perfusion. A nonrandomized trial was performed on cDCD donors. In abdominal normothermic regional perfusion (A-NRP), the thoracic aorta was blocked with an intra-aortic occlusion balloon. In thoracoabdominal normothermic regional perfusion (TA-NRP), ...
Tópico(s): Liver Disease and Transplantation
2023 - Elsevier BV | American Journal of Transplantation
Robert M. Dietz, Ivelisse Cruz‐Torres, James E. Orfila, Olivia P Patsos, Kaori Shimizu, Nicholas Chalmers, Guiying Deng, Erika Tiemeier, Nidia Quillinan, Paco S. Herson,
Hippocampal injury and cognitive impairments are common after cardiac arrest and stroke and do not have an effective intervention despite much effort. Therefore, we developed a new approach aimed at reversing synaptic dysfunction by targeting TRPM2 channels. Cardiac arrest/cardiopulmonary resuscitation (CA/CPR) in mice was used to investigate cognitive deficits and the role of the calcium-permeable ion channel transient receptor potential-M2 (TRPM2) in ischemia-induced synaptic dysfunction. Our data ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - Springer Science+Business Media | Translational Stroke Research
Guillem Pascual‐Pasto, Nagore G. Olaciregui, Mònica Vilà-Ubach, Sonia Paco, Carles Monterrubio, Eva Rodríguez, Ursula Winter, Mireia Batalla-Vilacis, Jaume Catalá, Héctor Salvador, Andreu Parareda, Paula Schaiquevich, Mariona Suñol, Jaume Mora, Cinzia Lavarino, Carmen de Torres, Guillermo Chantada, Ángel M. Carcaboso,
Translational research in retinoblastoma – a pediatric tumor that originates during the development of the retina – would be improved by the creation of new patient-derived models. Using tumor samples from enucleated eyes we established a new battery of preclinical models that grow in vitro in serum-free medium and in vivo in immunodeficient mice. To examine whether the new xenografts recapitulate human disease and disseminate from the retina to the central nervous system, we evaluated their histology ...
Tópico(s): Glioma Diagnosis and Treatment
2016 - Elsevier BV | Cancer Letters
Yam Zul Ernesto Ocampo-Díaz, Carita Augustsson, Martín Guerrero-Suastegui, Jorge Aceves de Alba, José Rafael Barboza-Gudiño, Margarita Martínez-Paco, Sonia Alejandra Torres-Sánchez,
In this study, we track the evolution of a clastic shoreline before carbonate deposition takes over. The Late Jurassic to Early Cretaceous La Casita Formation in northeastern Mexico serves as an excellent example for such a shoreline. The work includes a re-interpretation of the tectono-sedimentary environment. The La Casita Formation includes nine facies associations related to river, wave, storm, and tidal processes along a deltaic coastline. Systems influenced by rivers develop more muddy successions ...
Tópico(s): Paleontology and Stratigraphy of Fossils
2022 - Elsevier BV | Journal of South American Earth Sciences
Carles Monterrubio, Sonia Paco, Nagore G. Olaciregui, Guillem Pascual‐Pasto, Mònica Vilà-Ubach, Maria Cuadrado‐Vilanova, M. Mar Ferrandiz, Helena Castillo‐Ecija, Romina J. Glisoni, Nataliya Kuplennik, Achim A. Jungbluth, Carmen de Torres, Cinzia Lavarino, N K Cheung, Jaume Mora, Alejandro Sosnik, Ángel M. Carcaboso,
Tópico(s): Lung Cancer Research Studies
2017 - Elsevier BV | Journal of Controlled Release
Hugo Díaz V., Juan Espinoza B., Wilfredo Huanca L., Bernardo López-Torres, José Rodríguez G.,
El objetivo del estudio fue determinar y comparar las características bioquímicas del plasma seminal de alpacas en fresco y descongelado. Se recolectó semen, mediante electroeyaculación de cuatro alpacas adultas, una vez por semana por cuatro semanas. El semen se centrifugó y el plasma seminal fue separado. Una parte se analizó en fresco y la otra parte se almacenó en nitrógeno líquido por un mes. Se le hizo el análisis bioquímico a ambos juegos de muestras. Se determinaron los niveles de glucosa, ...
Tópico(s): Hormonal and reproductive studies
2015 - Universidad Nacional Mayor de San Marcos, Vicerectorado de Investigacion | Revista de Investigaciones Veterinarias del Perú
A. N. C. Castro, M. T. Domínguez, Silvina Gómez, G. J. Mendoza Torres, C Zavala, Marcelo Daniel Ghezzi, Cláudio Gustavo Barbeito,
South American camelids have several biological, morphological and behavioural adaptations that allow them to live in geographical areas dominated by high altitudes. The liver has hematopoietic functions during the prenatal life, which could be modified in response to the unfavorable habitat. However, there are no previous data on the prenatal development of the liver in these species. In the present work, a study on the macroscopic and microscopic morphology of the liver of the alpaca during ontogeny ...
Tópico(s): High Altitude and Hypoxia
2015 - Wiley | Anatomia Histologia Embryologia
A Ruíz-Torres, David Vicent, Graciano Sánchez de Paco, Francisco José Muñoz, Ana Gimeno, Raffaele Carraro,
The urinary C-peptide excretion was measured in a healthy standardized population sample of 160 subjects from 20 to 90 years of age, homogeneously distributed by age and sex. Urinary C-peptide excretion corresponded to 7% of the total amount released. The daily C-peptide excretion was 61.23 +/- 2.2 (S.E.) microg in the whole sample which corresponds to 41.9 +/- 1.5 IU of insulin secreted/day (I(CP)d), without sex differences. There is an increase of the I(CP)d value from the young to the healthy middle-aged ...
Tópico(s): Diabetes Management and Research
1996 - Elsevier BV | Archives of Gerontology and Geriatrics
El historiador Eustáquio Ornelas Cota escribe A formação da Coleção Latino- Americana do MoMA: arte, cultura e política (1931-1943) en el marco del trabajo de investigación desarrollado en su carrera de doctorado (2017) y Máster (2016) en Historia Social de la Universidad de São Paulo (FFLCH / USP).1 Cota estudia el proceso de formación de la colección latinoamericana del Museo de Arte Moderno de Nueva York (MoMA) teniendo en cuenta la acción diplomática de los Estados Unidos sobre los países vecinos y ...
Tópico(s): History, Culture, and Society
2020 - University of Cartagena | El Taller de la Historia
Yam Zul Ernesto Ocampo-Díaz, Sonia Alejandra Torres-Sánchez, Carita Augustsson, José Rafael Barboza-Gudiño, José Luis García-Díaz, Óscar Talavera-Mendoza, Jorge Aceves de Alba, Javier Castro-Larragoitia, Margarita Martínez-Paco, Ricardo Saucedo, Alfredo Aguillón‐Robles,
We present a modified model for the paleogeographic evolution of Mexico during Early and Late Jurassic time that is constrained by the tectonic setting and the weathering conditions of the Early Jurassic Huayacocotla Formation and Late Jurassic Alamitos Sandstone basins in state San Luis Potosí in central Mexico. Framework petrography constrains feldspato-quartzose sandstone (mean of Q68F22L10) and litho-quartzose (mean of Q75F6L19) sandstone compositions for the two units, respectively. The abundant ...
Tópico(s): Geochemistry and Elemental Analysis
2019 - Elsevier BV | Geochemistry
Allee C Torres, Vikhyat S. Bebarta, Michael D. April, Joseph K. Maddry, Paco S. Herson, Emma K Bebarta, Steven G Schauer,
Background The Tactical Combat Casualty Care (TCCC) guidelines recommend ketamine as the primary battlefield analgesic in the setting of moderate-to-severe pain and hemodynamic compromise. However, despite recent studies failing to support the association between ketamine and worse outcomes in head trauma, TCCC guidelines state that ketamine may worsen severe traumatic brain injury. We compared mortality outcomes following head trauma sustained in a combat setting between ketamine recipients and ...
Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation
2020 - Cureus, Inc. | Cureus
Se reconstruye el regicidio de Lisboa de 1908, que fue acogido con indiferencia por el pueblo y abrio el camino a la republica.
Tópico(s): History, Culture, and Society
2007 - | La Aventura de la historia
Ivelisse Cruz‐Torres, Paco S. Herson,
Introduction TRPM2 are calcium (Ca 2+ )‐permeable ion channels highly expressed in the brain, playing a critical role in neuronal injury and death following cerebral ischemia caused by stroke or cardiac arrest (CA). CA leads to impairment of long‐term potentiation (LTP), which is a cellular correlate for enhanced synaptic communication in neurons, for at least 30 days. This impairment is associated to cognitive and memory deficits in patients. Our preliminary data suggest that TRPM2 inhibition reverses ...
Tópico(s): Ion Channels and Receptors
2018 - Wiley | The FASEB Journal
D. R. Câmara, K. A. C. P. Lima, T. R. Pacó, F. C. R. Torres, A. N. Diniz,
Tópico(s): Gastrointestinal disorders and treatments
2019 - | Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP
... Dominios Ultramarinos, Comendadordas Ordens de Cristo e da Torre Espada, Provedor-Mor da Saude etc., etc., etc. Riode Janeiro, na Imprensa Regia, 1814. Com licenca da Mesa do Desembargo do Paco.(Acervo da Fundacao Biblioteca Nacional – Brasil. Setor de ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2011 - University Association for Research in Fundamental Psychopathology | Revista Latinoamericana de Psicopatologia Fundamental
Produção Nacional
Revisado por pares
Luis Llanco, Karubya Retamozo, Noriko Oviedo, Alberto Manchego S., C. Torre, Dennis Navarro M., Norma Santos, Miguel Rojas,
Coronaviruses (CoVs) infect a wide range of hosts, including humans, domestic animals, and wildlife, typically causing mild-to-severe respiratory or enteric disease. The main objective of this study was to identify CoV genera and subgenera detected in Peruvian alpacas. Lung lavage specimens were collected from 32 animals aged 1 to 6 weeks. CoVs were identified by using RT-PCR to amplify a pan-CoV conserved region of the RNA-dependent RNA polymerase-encoding gene. A nested PCR was performed to identify ...
Tópico(s): Virus-based gene therapy research
2023 - Multidisciplinary Digital Publishing Institute | Animals