Daniel Alcolea, Pablo Martínez‐Lage, Pascual Sánchez‐Juan, Javier Olazarán, Carmen Antúnez, Andrea Izagirre, M. Ecay, Ainara Estanga, Montserrat Clerigué, M.C. Guisasola, Domingo Sánchez Ruíz, Juan Marín, Miguel Calero, Rafael Blesa, Jordi Clarimón, María Carmona‐Iragui, Estrella Morenas‐Rodríguez, Eloy Rodríguez‐Rodríguez, José Luis Vázquez Higuera, Juan Fortea, Alberto Lleó,
Objective: To investigate CSF markers involved in amyloid precursor protein processing, neuronal damage, and neuroinflammation in the preclinical stages of Alzheimer disease (AD) and participants with suspected non-Alzheimer pathology (SNAP). Methods: We collected CSF from 266 cognitively normal volunteers participating in a cross-sectional multicenter study (the SIGNAL study) to investigate markers involved in amyloid precursor protein processing (Aβ42, sAPPβ, β-secretase activity), neuronal damage (total-tau [ ...
Tópico(s): Tryptophan and brain disorders
2015 - Lippincott Williams & Wilkins | Neurology
Eloy Rodríguez‐Rodríguez, Pascual Sánchez‐Juan, José Luis Vázquez‐Higuera, Ignacio Mateo, Ana Pozueta, José Berciano, Sebastián Cervantes, Daniel Alcolea, Pablo Martínez‐Lage, Jordi Clarimón, Alberto Lleó, Pau Pástor, Onofre Combarros,
Aside from APOE, the genetic factors that influence the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) remain largely unknown. We assessed whether a genetic risk score (GRS), based on eight non-APOE genetic variants previously associated with AD risk in genome-wide association studies, is associated with either risk of conversion or with rapid progression from MCI to AD. Among 288 subjects with MCI, follow-up (mean 26.3 months) identified 118 MCI-converters to AD and 170 ...
Tópico(s): Epigenetics and DNA Methylation
2012 - Springer Science+Business Media | Journal of Neural Transmission
Daniel Alcolea, Pablo Martínez‐Lage, Andrea Izagirre, Montserrat Clerigué, María Carmona‐Iragui, Rosa Álvarez, Juan Fortea, Mircea Balasa, Estrella Morenas‐Rodríguez, Albert Lladó, Oriol Grau‐Rivera, Kaj Blennow, Alberto Lleó, José Luís Molinuevo,
Lumbar puncture (LP) is increasingly performed in memory units due to the usefulness of cerebrospinal fluid (CSF) biomarkers in the diagnosis of Alzheimer's disease. The feasibility of this procedure in this context, however, is controversial.Our aim was to analyze the incidence of complications and their associated factors so as to determine the impact of LP in the study of CSF biomarkers of Alzheimer's disease.In the context of a larger international initiative, we prospectively collected data from ...
Tópico(s): Dementia and Cognitive Impairment Research
2014 - IOS Press | Journal of Alzheimer s Disease
Alberto Lleó, Daniel Alcolea, Pablo Martínez‐Lage, Philip Scheltens, Lucilla Parnetti, Judes Poirier, Anja Hviid Simonsen, Marcel M. Verbeek, Pedro Rosa‐Neto, Rosalinde E.R. Slot, Mikel Tainta, Andréa Gomes Coelho Izaguirre, Babette L.R. Reijs, Lucia Farotti, Magda Tsolaki, Rik Vandenbergue, Yvonne Freund‐Levi, Frans R.J. Verhey, Jordi Clarimón, Juan Fortea, Lutz Frölich, Isabel Santana, José Luís Molinuevo, Sylvain Lehmann, Pieter Jelle Visser, Charlotte E. Teunissen, Henrik Zetterberg, Kaj Blennow,
Abstract Introduction Within‐person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. Methods We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild cognitive impairment (n = 128), and AD dementia (n = 110), and a group of cognitively unimpaired subjects (n = 154) were also included. We measured baseline and follow‐up CSF levels of total tau (t‐tau), phosphorylated tau ( ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2019 - Wiley | Alzheimer s & Dementia
Elena Jiménez Cubedo, Javier López Monclús, José Luis Lucena de la Poza, Natalia González Alcolea, Pablo Calvo Espino, Arturo García Pavía, Víctor Sánchez Turrión,
endoscopic retrograde cholangiopancreatography (ERCP) remains the gold standard in biliary and pancreatic pathology. Although the procedure has a significant morbidity and mortality rate. Algorithms are needed for the management and treatment of the associated complications.to review the post-ERCP perforations treated in the Department of General Surgery of the Hospital Puerta de Hierro from 1999 to 2014. The results were evaluated according to the types of perforation and treatment.this is a descriptive ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2018 - Arán Ediciones | Revista Española de Enfermedades Digestivas
Liu Shi, Sarah Westwood, Alison L. Baird, Laura Winchester, Valerija Dobričić, Fabian Kilpert, Shengjun Hong, André Franke, Abdul Hye, Nicholas J. Ashton, Angharad R. Morgan, Isabelle Bos, Stephanie J. B. Vos, Noel J. Buckley, Mara ten Kate, Philip Scheltens, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen De Roeck, Kristel Sleegers, Giovanni B. Frisoni, Olivier Blin, Jill Richardson, Régis Bordet, José Luís Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lleó, Daniel Alcolea, Julius Popp, Gwendoline Peyratout, Pablo Martínez‐Lage, Mikel Tainta, Peter Johannsen, Charlotte E. Teunissen, Yvonne Freund‐Levi, Lutz Frölich, Cristina Legido‐Quigley, Frederik Barkhof, Kaj Blennow, Henrik Zetterberg, Susan Baker, B. Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Lars Bertram, Simon Lovestone, Alejo Nevado‐Holgado,
Abstract Introduction Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins. Methods 4001 plasma proteins were measured in two groups of participants (discovery group = 516, replication group = 365) selected from the European Medical Information Framework ...
Tópico(s): Bioinformatics and Genomic Networks
2019 - Wiley | Alzheimer s & Dementia
Verónica Alcolea, Pablo Garnica, Juan Antonio Palop, Carmen Sanmartín, Elena González‐Peñas, A. Durán, Elena Lizarraga,
The physicochemical properties of a compound play a crucial role in the cancer development process. In this context, polymorphism can become an important obstacle for the pharmaceutical industry because it frequently leads to the loss of therapeutic effectiveness of some drugs. Stability under manufacturing conditions is also critical to ensure no undesired degradations or transformations occur. In this study, the thermal behaviour of 40 derivatives of a series of sulphur and selenium heteroaryl ...
Tópico(s): Synthesis and biological activity
2017 - Multidisciplinary Digital Publishing Institute | Molecules
Pablo Burriel Llombart, M. Alcolea Palafox, Luis G. MacDowell, Eva G. Noya,
Controlled CTAB self-assembly is an essential prerequisite for the formation of gold nanorods with tailored shape and monodispersity. In this paper, we exploit the use of salt concentration and co-surfactant decanol for the preparation of CTAB aggregates with different morphologies. To this end we use a model of CTAB recently developed by ourselves, and perform electronic structure calculations in order to improve current point charge parametrization of decanol. Using molecular dynamics simulations ...
Tópico(s): Polymer Surface Interaction Studies
2019 - Elsevier BV | Colloids and Surfaces A Physicochemical and Engineering Aspects
Shengjun Hong, Valerija Dobričić, Olena Ohlei, Isabelle Bos, Stephanie J. B. Vos, Dmitry Prokopenko, Betty M. Tijms, Ulf Andréasson, Kaj Blennow, Rik Vandenberghe, Silvy Gabel, Philip Scheltens, Charlotte E. Teunissen, Sebastiaan Engelborghs, Giovanni B. Frisoni, Olivier Blin, Jill Richardson, Régis Bordet, Alberto Lleó, Daniel Alcolea, Julius Popp, Christopher Clark, Gwendoline Peyratout, Pablo Martínez‐Lage, Mikel Tainta, Richard Dobson, Cristina Legido‐Quigley, Kristel Sleegers, Christine Van Broeckhoven, Rudolph E. Tanzi, Mara ten Kate, Michael Wittig, Andre Franke, Christina M. Lill, Frederik Barkhof, Simon Lovestone, Johannes Streffer, Henrik Zetterberg, Pieter Jelle Visser, Lars Bertram,
Abstract Introduction Neurofilament light (NfL), chitinase‐3‐like protein 1 (YKL‐40), and neurogranin (Ng) are biomarkers for Alzheimer's disease (AD) to monitor axonal damage, astroglial activation, and synaptic degeneration, respectively. Methods We performed genome‐wide association studies (GWAS) using DNA and cerebrospinal fluid (CSF) samples from the EMIF‐AD Multimodal Biomarker Discovery study for discovery, and the Alzheimer's Disease Neuroimaging Initiative study for validation analyses. GWAS ...
Tópico(s): Studies on Chitinases and Chitosanases
2021 - Wiley | Alzheimer s & Dementia
Jan Homann, Tim Osburg, Olena Ohlei, Valerija Dobričić, Laura Deecke, Isabelle Bos, Rik Vandenberghe, Silvy Gabel, Philip Scheltens, Charlotte E. Teunissen, Sebastiaan Engelborghs, Giovanni B. Frisoni, Olivier Blin, Jill Richardson, Régis Bordet, Alberto Lleó, Daniel Alcolea, Julius Popp, Christopher Clark, Gwendoline Peyratout, Pablo Martínez‐Lage, Mikel Tainta, Richard Dobson, Cristina Legido‐Quigley, Kristel Sleegers, Christine Van Broeckhoven, Michael Wittig, André Franke, Christina M. Lill, Kaj Blennow, Henrik Zetterberg, Simon Lovestone, Johannes Streffer, Mara ten Kate, Stephanie J. B. Vos, Frederik Barkhof, Pieter Jelle Visser, Lars Bertram,
Alzheimer’s disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility has an established genetic basis which has been the focus of a large number of genome-wide association studies (GWAS) published over the last decade. Most of these GWAS used dichotomized clinical diagnostic status, i.e., case vs. control classification, as outcome phenotypes, without the use of biomarkers. An alternative and potentially more ...
Tópico(s): Alzheimer's disease research and treatments
2022 - Frontiers Media | Frontiers in Aging Neuroscience
Alberto Lleó, Daniel Alcolea, Pablo Martínez‐Lage, Philip Scheltens, Lucilla Parnetti, Judes Poirier, Anja Hviid Simonsen, Marcel M. Verbeek, Pedro Rosa‐Neto, Rosalinde E.R. Slot, Mikel Tainta, Andrea Izagirre, Babette L.R. Reijs, Lucia Farotti, Juan Fortea, Lutz Frölich, Isabel Santana, José Luís Molinuevo, Silvain Lehmann, Pieter Jelle Visser, Charlotte E. Teunissen, Henrik Zetterberg, Kaj Blennow,
Our aim was to characterize the within-person trajectories of cerebrospinal fluid (CSF) biomarkers along the Alzheimer's disease (AD) continuum. We included 407 subjects from the multicenter BIOMARKAPD project from whom at least two CSF samples were obtained. Baseline diagnosis were: healthy controls (HC=146), subjective cognitive decline (SCD=71), mild cognitive impairment (MCI=101), and AD dementia (AD=89). We measured baseline and follow-up CSF levels of amyloid-β (Aβ)1–42, Aβ1–40, Aβ1–38, total tau ( ...
Tópico(s): Dementia and Cognitive Impairment Research
2017 - Wiley | Alzheimer s & Dementia
Guillermo González‐Rubio, Pablo Díaz‐Núñez, A. Rivera, Alejandro Prada, G. Tardajos, J. G. Izquierdo, Luis Bañares, Pablo Burriel Llombart, Luis G. MacDowell, M. Alcolea Palafox, Luis M. Liz‐Marzán, O. Peña, Andrés Guerrero‐Martínez,
The irradiation of gold nanorod colloids with a femtosecond laser can be tuned to induce controlled nanorod reshaping, yielding colloids with exceptionally narrow localized surface plasmon resonance bands. The process relies on a regime characterized by a gentle multishot reduction of the aspect ratio, whereas the rod shape and volume are barely affected. Successful reshaping can only occur within a narrow window of the heat dissipation rate: Low cooling rates lead to drastic morphological changes, ...
Tópico(s): Nonlinear Optical Materials Studies
2017 - American Association for the Advancement of Science | Science
Liu Shi, Laura Winchester, Benjamine Young Liu, Richard Killick, Elena M. Ribé, Sarah Westwood, Alison L. Baird, Noel J. Buckley, Shengjun Hong, Valerija Dobričić, Fabian Kilpert, André Franke, Steven J. Kiddle, Martina Sattlecker, Richard Dobson, Antonio Cuadrado, Abdul Hye, Nicholas J. Ashton, Angharad R. Morgan, Isabelle Bos, Stephanie J. B. Vos, Mara ten Kate, Philip Scheltens, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen De Roeck, Kristel Sleegers, Giovanni B. Frisoni, Olivier Blin, Jill Richardson, Régis Bordet, José Luís Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans R.J. Verhey, Alberto Lleó, Daniel Alcolea, Julius Popp, Gwendoline Peyratout, Pablo Martínez‐Lage, Mikel Tainta, Peter Johannsen, Charlotte E. Teunissen, Yvonne Freund‐Levi, Lutz Frölich, Cristina Legido‐Quigley, Frederik Barkhof, Kaj Blennow, Katrine Laura Rasmussen, Børge G. Nordestgaard, Ruth Frikke‐Schmidt, Yan V. Sun, Hilkka Soininen, Bruno Vellas, Iwona Kłoszewska, Patrizia Mecocci, Henrik Zetterberg, B. Paul Morgan, Johannes Streffer, Pieter Jelle Visser, Lars Bertram, Alejo Nevado‐Holgado, Simon Lovestone,
Background: Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer’s disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. Objective: We aim to test whether DKK1 induced protein signature obtained in vitro were associated with markers of AD pathology as used in the amyloid/tau/neurodegeneration (ATN) framework as well as with clinical ...
Tópico(s): Amino Acid Enzymes and Metabolism
2020 - IOS Press | Journal of Alzheimer s Disease
Ane Miren Andrés, Paloma Talayero, Alida Alcolea Sánchez, Alba Galán, Javier Serradilla, A. Jiménez, Rocío González Sacristán, Pablo Stringa, Rodrigo Papa Gobbi, Maria Lasa Lazaro, Mariana Díaz Almirón, Esther Ramos Boluda, Manuel Santamarı́a, F Hernández,
To review our experience using sirolimus in a single centre paediatric intestinal transplantation cohort. Intestinal transplant patients with more than 3 months follow-up were divided into two groups according to their immunosuppression regimen: tacrolimus, (TAC group, n = 45 grafts) or sirolimus (SRL group, n = 38 grafts), which included those partially or completely converted from tacrolimus to sirolimus. The indications to switch were tacrolimus side effects and immunological complications. Survival ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2021 - Springer Science+Business Media | Transplant International
Alexander Neumann, Olena Ohlei, Fahri Küçükali, Isabelle Bos, Jigyasha Timsina, Stephanie J. B. Vos, Dmitry Prokopenko, Betty M. Tijms, Ulf Andréasson, Kaj Blennow, Rik Vandenberghe, Philip Scheltens, Charlotte E. Teunissen, Sebastiaan Engelborghs, Giovanni B. Frisoni, Oliver Blin, Jill Richardson, Régis Bordet, Alberto Lleó, Daniel Alcolea, Julius Popp, Thomas W. Marsh, Priyanka Gorijala, Christopher Clark, Gwendoline Peyratout, Pablo Martínez‐Lage, Mikel Tainta, Richard Dobson, Cristina Legido‐Quigley, Christine Van Broeckhoven, Rudolph E. Tanzi, Mara ten Kate, Christina M. Lill, Frederik Barkhof, Carlos Cruchaga, Simon Lovestone, Johannes Streffer, Henrik Zetterberg, Pieter Jelle Visser, Kristel Sleegers, Lars Bertram,
Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified several risk loci, but many remain unknown. Cerebrospinal fluid (CSF) biomarkers may aid in gene discovery and we previously demonstrated that six CSF biomarkers (β-amyloid, total/phosphorylated tau, NfL, YKL-40, and neurogranin) cluster into five principal components (PC), each representing statistically independent biological processes. Here, we aimed to (1) identify common genetic variants associated with these CSF profiles, ( ...
Tópico(s): Gene expression and cancer classification
2023 - BioMed Central | Genome Medicine
Lluı́s Samaranch, Sebastián Cervantes, Ana Barabash, Álvaro Alonso, José A. Cabranes, Isabel Lamet, Inés Ancín, Elena Lorenzo, Pablo Martínez‐Lage, Alberto Marcos, Jordi Clarimón, Daniel Alcolea, Alberto Lleó, Rafael Blesa, Teresa Gómez‐Isla, Pau Pástor,
Microtubule-associated protein tau (MAPT) and apolipoprotein E (APOE) are involved in the pathogenic mechanisms of Alzheimer's disease (AD). We prospectively followed three longitudinal independent samples (total n = 319) with amnestic mild cognitive
Tópico(s): Neurological Disease Mechanisms and Treatments
2011 - IOS Press | Journal of Alzheimer s Disease
Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris E. Jansen, Eric Yu, Aude Nicolas, Itziar de Rojas, Thiago Peixoto Leal, Akinori Miyashita, Céline Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier‐Boley, Tatsuhiko Naito, Fahri Küçükali, Seth D. Talyansky, Selina Yogeshwar, Vicente Peris Sempere, Wataru Satake, Victoria Álvarez, Beatrice Arosio, Michaël E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, María J. Bullido, Paolo Caffarra, Jordi Clarimón, Antonio Daniele, D.H. Darling, Stéphanie Debette, Jean‐François Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Düzel, Daniela Galimberti, Guillermo García‐Ribas, José María García‐Alberca, Pablo García‐González, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann‐Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Jürgen Deckert, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonça, Merçé Boada, Pablo Mir, Susanne Moebus, Fermín Moreno, Benedetta Nacmias, Gaël Nicolas, Shumpei Niida, Børge G. Nordestgaard, Goran Papenberg, Janne M. Papma, Lucilla Parnetti, Florence Pasquier, Pau Pástor, Oliver Peters, Yolande A.L. Pijnenburg, Gerard Piñol‐Ripoll, Julius Popp, Laura Molina‐Porcel, Raquel Puerta, Jordi Pèrez‐Tur, Innocenzo Rainero, Inez H.G.B. Ramakers, Luís Miguel Real, Steffi G. Riedel‐Heller, Eloy Rodríguez‐Rodríguez, Owen A. Ross, José Luís Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John C. van Swieten, Raquel Sánchez‐Valle, Eng‐King Tan, Thomas Tegos, Charlotte E. Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnálek, Frans Verhey, Margda Wærn, Jens Wiltfang, Jing Zhang, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia van Duin, Magda Tsolaki, Pascual Sánchez-Juan, Ruth Frikke‐Schmidt, Kristel Sleegers, Tatsushi Toda, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje M. van der Flier, Takeshi Ikeuchi, Alfredo Ramı́rez, Ignácio F. Mata, Agustı́n Ruiz, Ziv Gan‐Or, Jean‐Charles Lambert, Michael D. Greicius, Emmanuel Mignot, Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Víctor Andrade, Sonia Moreno‐Grau, Najaf Amin, Benjamin Grenier‐Boley, Rafael Campos‐Martin, Peter Holmans, Anne Boland, Luca Kleineidam, Vincent Damotte, Sven J. van der Lee, Teemu Kuulasmaa, Itziar de Rojas, Amber Yaqub, Ivana Nedeljković, Marcos R. Costa, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo García‐González, Carla Abdelnour, Emilio Alarcón‐Martín, Daniel Alcolea, Montserrat Alegret, Ignacio Álvarez, Victoria Álvarez, Nicola J. Armstrong, Tsolaki Anthoula, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Ana Belén Pastor, Luisa Benussi, Claudine Berr, Céline Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Merçé Boada, Barbara Borroni, Silvia Boschi, Paola Bossù, Geir Bråthen, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis I. Brusco, Dolores Buiza‐Rueda, Katharina Bürger, Vanessa Burholt, Miguel Calero, Geneviève Chêne, Ãngel Carracedo, Roberta Cecchetti, Laura Cervera‐Carles, Camille Charbonnier, Caterina Chillotti, Simona Ciccone, Jurgen A.H.R. Claassen, Jordi Clarimón, Christopher Clark, Elisa Conti, Anaïs Corma‐Gómez, Emanuele Maria Costantini, Carlo Custodero, Delphine Daian, Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean‐François Dartigues, Peter Paul De Deyn, Stéphanie Debette, Jürgen Deckert, Teodoro del Ser, Nicola Denning, Martin Dichgans, Janine Diehl‐Schmid, Mónica Díez-Fairén, Paolo Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Düzel, Carole Dufouil, Valentina Escott‐Price, Ana Espinosa, Michael Ewers, Marta Fernández‐Fuertes, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fließbach, Juan Fortea, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macías, María J. Bullido, Ana Frank, Lutz Froelich, Daniela Galimberti, José María García‐Alberca, Pablo García‐González, Sebastián García‐Madrona, Guillermo García‐Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Oliver Goldhardt, Antonio González-Pérez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grünblatt, Tamar Guetta-Baranés, Annakaisa Haapasalo, Georgios M. Hadjigeorgiou, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann‐Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel de la Torre Díez, Martin J. Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Charlotte Johansson, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne M. Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Carmen Lage, Erika J. Laukka,
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of
National Academy of Sciences
Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia Moreno‐Grau, Najaf Amin, Adam C. Naj, Rafael Campos‐Martin, Benjamin Grenier‐Boley, Víctor Andrade, Peter Holmans, Anne Boland, Vincent Damotte, Sven J. van der Lee, Marcos R. Costa, Teemu Kuulasmaa, Qiong Yang, Itziar de Rojas, Joshua C. Bis, Amber Yaqub, Ivana Nedeljković, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo García‐González, Carla Abdelnour, Emilio Alarcón‐Martín, Daniel Alcolea, Montserrat Alegret, Ignacio Álvarez, Victoria Álvarez, Nicola J. Armstrong, Anthoula Tsolaki, Carmen Antúnez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Sandra Barral, Alexa S. Beiser, Ana Belén Pastor, Jennifer E. Below, Penelope Benchek, Luisa Benussi, Claudine Berr, Céline Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Merçé Boada, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossù, Geir Bråthen, Jan Bressler, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis I. Brusco, Dolores Buiza‐Rueda, Katharina Bürger, Vanessa Burholt, William S. Bush, Miguel Calero, Laura B. Cantwell, Geneviève Chêne, Jaeyoon Chung, Michael L. Cuccaro, Ãngel Carracedo, Roberta Cecchetti, Laura Cervera‐Carles, Camille Charbonnier, Hung‐Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A.H.R. Claassen, Christopher Clark, Elisa Conti, Anaïs Corma‐Gómez, Emanuele Maria Costantini, Carlo Custodero, Delphine Daian, Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean‐François Dartigues, Peter Paul De Deyn, Kátia de Paiva Lopes, Lot D. de Witte, Stéphanie Debette, Jürgen Deckert, Teodoro del Ser, Nicola Denning, Anita L. DeStefano, Martin Dichgans, Janine Diehl‐Schmid, Mónica Díez-Fairén, Paolo Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Düzel, Carole Dufouil, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott‐Price, Ana Espinosa, Michael Ewers, Kelley M. Faber, Fabrizio Tagliavini, Yan V. Sun, David W. Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernández‐Fuertes, Raffaele Ferrari, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fließbach, Bernard Fongang, Myriam Fornage, Juan Fortea, Tatiana M. Foroud, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macías, María J. Bullido, Ana Frank, Lutz Froelich, Brian Fulton‐Howard, Daniela Galimberti, José María García‐Alberca, Pablo García‐González, Sebastián García‐Madrona, Guillermo García‐Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison Goate, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio González‐Pérez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grünblatt, Michelle Grunin, Vilmundur Guðnason, Tamar Guetta-Baranés, Annakaisa Haapasalo, Georgios M. Hadjigeorgiou, Jonathan L. Haines, Kara L. Hamilton‐Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M. Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann‐Heimbach, Seppo Helisalmi, Michael T. Heneka, Isabel Hernández, Martin J. Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels, Xueqiu Jian, Charlotte Johansson, Gyungah Jun, Yuriko Kastumata, John Kauwe, Patrick G. Kehoe, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Walter A. Kukull, Pavel P. Kuksa, Brian W. Kunkle, Amanda Kuzma, Carmen Lage, Erika J. Laukka, Lenore J. Launer, Alessandra Lauria, Chien‐Yueh Lee, Jenni Lehtisalo, Ondřej Lerch, Alberto Lleó, W.T. Longstreth, Oscar L. López, Adolfo López de Munain, Seth Love, Malin Löwemark, Lauren Luckcuck, Kathryn L. Lunetta, Yiyi Ma, Juan Macías, Catherine Macleod, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquié, Iain Marshall, Eden R. Martin, Angel Martín Montes, Carmen Martínez Rodríguez, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Miguel Medina, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menéndez‐González, Pablo Mir, Susanne Moebus, Merel O. Mol, Laura Molina‐Porcel, Laura Montrreal, Laura Morelli, Fermín Moreno, Kevin Morgan, Sonia Thomas, Markus M. Nöthen, Carolina Muchnik, Shubhabrata Mukherjee, Benedetta Nacmias, Tiia Ngandu, Gaël Nicolas, Børge G. Nordestgaard, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Paolo Caffarra, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Pau Pástor, Gina M. Peloso, Alba Pérez‐Cordón, Jordi Pèrez‐Tur, Pierre Péricard, Oliver Peters, Yolande A.L. Pijnenburg, Juan A. Pineda, Gerard Piñol-Ripoll, Claudia Pisanu, Thomas Polak, Julius Popp, Daniëlle Posthuma, Josef Priller, Raquel Puerta, Olivier Quenez, Inés Quintela, Jesper Qvist Thomassen, Alberto Rábano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luís Miguel Real, Marcel J. T. Reinders, Christiane Reitz, Dolly Reyes‐Dumeyer, Perry Ridge, Steffi G. Riedel‐Heller, Peter Riederer, Natalia Roberto, Eloy Rodríguez‐Rodríguez, Arvid Rongve, Irene Rosas Allende, Maitée Rosende-Roca, José Luís Royo, Elisa Rubino, Dan Rujescu, María Eugenia Sáez,
Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted ...
Nature Portfolio
Laura Cervera‐Carles, Daniel Alcolea, Ainara Estanga, M. Ecay, Andrea Izagirre, Montserrat Clerigué, Maite García-Sebastián, Jorge Villanúa, Clàudia Escalas, Rafael Blesa, Pablo Martínez‐Lage, Alberto Lleó, Juan Fortea, Jordi Clarimón,
Tópico(s): Metabolomics and Mass Spectrometry Studies
2016 - Elsevier BV | Neurobiology of Aging
Sergio Pérez‐Oliveira, Ignacio Álvarez, Irene Rosas, Manuel Menéndez‐González, Marta Blázquez Estrada, Miquel Aguilar, María D. Corte‐Torres, Maríateresa Buongiorno, Laura Molina‐Porcel, Ibán Aldecoa, Marı́a José Martı́, Pascual Sánchez‐Juan, Jon Infante, Isabel González Aramburu, Pablo García‐González, Maitée Rosende‐Roca, Merçé Boada, Agustı́n Ruiz, María Teresa Periñán, Daniel Macías‐García, Laura Muñoz‐Delgado, Pilar Gómez‐Garre, Pablo Mir, Jordi Clarimón, Alberto Lleó, Daniel Alcolea, B. de la Casa Fages, Israel Duarte, Victoria Álvarez, Pau Pástor,
Previous studies suggest a link between CAG repeat number in the HTT gene and non-Huntington neurodegenerative diseases.The aim is to analyze whether expanded HTT CAG alleles and/or their size are associated with the risk for developing α-synucleinopathies or their behavior as modulators of the phenotype.We genotyped the HTT gene CAG repeat number and APOE-Ɛ isoforms in a case-control series including patients with either clinical or neuropathological diagnosis of α-synucleinopathy.We identified ...
Tópico(s): Cellular transport and secretion
2022 - Wiley | Movement Disorders
Pedro Jiménez‐Mejías, Saúl Manzano, Vinita Gowda, Frank‐Thorsten Krell, Mei-Ying Lin, Santiago Martín‐Bravo, Laura Martín-Torrijos, Gonzalo Nieto Feliner, Sergei L. Mosyakin, Robert F. C. Naczi, Carmen Acedo, Inés Álvarez, Jorge V. Crisci, Modesto Luceño, John C. Manning, Juan Carlos Moreno Sáiz, A. Muthama Muasya, Ricarda Riina, Andrea S. Meseguer, Daniel Sánchez‐Mata, Magdi S A El-Hawagry, Mohammad Amini Rad, Patrick Blandin, Michael Schmitt, Ryota Hayashi, Sangtae Kim, Anna Ronikier, Michał Ronikier, Sérgio Chozas, A. Dos Anjos, Guilherme Siniciato Terra Garbino, Mikhail Rogov, Manuel B Morales, Carlos Luis Leopardi Verde, Emre Çilden, Donald Shuka, Ermelinda Gjeta, Lulëzim Shuka, Marjol Meço, Spase Shumka, Abdelkader Nabil Benghanem, Djilali Tahri, Laouer Hocine, Rachid Meddour, Saidi Boubar, Salima Benhouhou, Clara Pladevall, Francisco M. P. Gonçalves, Abel Pérez‐González, Ana Valeria Carranza, Anıbal Prina, Darién E. Prado, Diego G. Gutiérrez, Elián L Guerrero, Esteban O. Lavilla, Eugenia Minghetti, Federico L. Agnolín, Graciela Lorna Alfosno, Juan José Cantero, Julián Faivovich, Liliana Katinas, Magdalena Laurito, Marcelo D. Arana, María Cecilia Melo, Maria Jimena Ponce, Mariela Fabbroni, Pablo E. Ortíz, Pablo Demaio, Pablo M. Dellapé, Pablo Teta, Roberto Kiesling, Alla Aleksanyan, George Fayvush, Brian Jones, Daniel J. Bickel, Eckart Håkansson, Elena K. Kupriyanova, Glenn M. Shea, Jürgen Kellermann, Karen L. Wilson, Ladislav Mucina, Nicholas A. Morris, Peter S. Cranston, Peter Crossing, P. G. Allsopp, P.A.M. Weston, Raymond Hoser, Rohan Pethiyagoda, Scott Eipper, Trevor Henry Worthy, Vratislav Ricardo Bejsak-Colloredo-Mansfeld, Božo Frajman, Clemens Pachschwöll, Gerald M. Schneeweiss, Gerhard Pils, Hermann Voglmayr, Irmgard Krisai‐Greilhüber, Konstantina Agiadi, Michael H. J. Barfuss, Peter Schönswetter, Wolfgang Willner, Alexander Lukashuk, В. Н. Тихомиров, Achik Dorchin, Arnaud Henrard, De Blauwe Hans, Filip Verloove, Guy Smagghe, Jacques Verniers, Jan Bosselaers, Jérôme Degreef, Kenny Meganck, Lars W. Chatrou, Louis Beyens, Luis M da Costa, Marc S.M. Sosef, Olivier S. G. Pauwels, Paolo Rosa, Paul Schoolmeesters, Pol Limbourg, S. Robbert Gradstein, Robert P. Speijer, Salvator Ntore, Thomas J. Wood, Willy De Prins, Nourou S. Yorou, Jigme Wangchuk, Lizette Siles, Luis F Aguirre, Luis Fernando Aguirre Urioste, Magaly Mercado U, Marita A Pareses-Rodríguez, Mauricio Ocampo, Pamela Jenny Carvajal Bacarreza, Avdul Adrović, Sadbera Trožić-Borovac, Demel Teketay Fanta, Adriano B. Kury, André Hoffmann, André Silva Fernandes, Axel M Katz, Bruno Machado Teles Walter, Clapton Olimpio de Moura, Cristiano Lopes‐Andrade, Dalton de Souza Amorim, Daniel C Cavallari, Daniel Loebmann, Diego Aguilar Fachin, Diego Nunes da Silva, Fernando Zagury Vaz‐de‐Mello, Francisco Langeani Neto, Gerson Paulino Lopes, Henrique Caldeira Costa, Henrique Mallmann Büneker, Isabel Paiola Gonçalves, John E. Lattke, José Albertíno Rafael, José M. P. Nascimento, José Rubens Pirani, Josimar Külkamp, Julian C G Silva, Katyuscia Araujo‐Vieira, Leandro Lacerda Giacomin, Leandro M. Vieira, Leandro Tavares Azevedo Vieira, Leonardo M. Borges, Leonardo M. Versieux, Lucas Cardoso Marinho, Lucas Sá Barreto Jordão, Luciano Paganucci de Queiroz, Marcelo Trovó, Marcelo Weksler, Marcos Gonçalves Lhano, Maria Beatriz Rossi Caruzo, Marinus Steven Hoogmoed, Maurício Figueira, M. A. Medrano, Milton Groppo, Omar Rojas Padilla, Otávio Luís Marques da Silva, Patricia Jacqueline Thyssen, Pedro Henrique Cardoso, Rafael A P Freitas Silva, Renata Trevizan, Ricardo de S. Secco, Rosângela Simão‐Bianchini, Scott Thomsom, Tamily C. M. Santos, Ulisses Caramaschi, Vinícius Sudré dos Santos, Weferson Júnio da Graça, Yuri Rossine, Johan Willem Frederik Slik, Ulmar Grafe, Anita Tosheva, Asen Asenov, Dolja Pavlova, Fedor Konstantinov, Georgi Kunev, Nikolay Simov, Alain Didier Missoup, Andrew M R Bennett, Brenda Hann, Chad Morgan, Étienne Lacroix-Carignan, Étienne Léveillé‐Bourret, Felix A. H. Sperling, Fenja Brodo, Geraldine A Allen, Gregory R. Pohl, James Basinger, Jean‐François Landry, John E Maunder, J. Huber, John W. Reynolds, Jonathan Cazabonne, Juan Carlos Villarreal, Matthias Buck, Mihai Costea, Olivier Barden, Quentin Cronk, Rafael Otfinowski, Santiago Claramunt, S. J. Darbyshire, Timothy Dickinson, William J Crins, Alicia Marticorena Garri, Diego Alarcón Abarca, Francisco A Squeo, Guillermo D’Elía, Jorge Pérez-Schultheiss, José Ángel García-Beltrán, Marcelo M. Rivadeneira, Sara Rodrı́guez, Sebastian Teillier, Sven N. Nielsen, Amaël Borzée, Zhao Bao-jun, Bismillah Shah, Caixia Yuan, Caixin Liu, Chen-Yan Liao, Chengyuan Liu, Chuan-Bu Gao, Chufei Tang, Chunhao Zhang, Clive Siu-Ki Lau, Dakang Zhou, Daniel R. Gustafsson, Dávid Rédei, Fangmeng Duan, Fenglong Jia, Fuqiang Chen, Guchun Zhou, GUI-QIANG HUANG, Hao Xu, Haoran Gao, Haodong Yan, Hassan Naveed, Hongbin Zhu, Hongliang Shi, Hu Li, Huilin Han, Jiliang Liu, Jia Huang, Jiabin Liu, Jian qiang Cao, Jian Sun, Jianwei Guo, Jianyu Chen, Jianjun Guo, Jiao Sun, Jiaxin Wang, Jingyu Zhai, Jingzhi Lin, Jinrui Zhang, Chen Jun, Jun Zhang, Junbo Tong, Kai Kang, Kai Wang, Kaiming Cai, Keping Ma, Kexin Xu, Kuiyan Zhang, Li Ren, Liang Tang, Lin Luo, Ling-Zeng Meng, Mei-Ying Lin, Meng Xie, Ming-Yu Liu, Muhammad Asghar Hassan, Panshuai Fei, Patrick Rioual, Peng Li,
The fundamental value of universal nomenclatural systems in biology is that they enable unambiguous scientific communication. However, the stability of these systems is threatened by recent discussions asking for a fairer nomenclature, raising the possibility of bulk revision processes for "inappropriate" names. It is evident that such proposals come from very deep feelings, but we show how they can irreparably damage the foundation of biological communication and, in turn, the sciences that depend ...
Oxford University Press
Daniel Stamate, Min Kim, Petroula Proitsi, Sarah Westwood, Alison L. Baird, Alejo Nevado‐Holgado, Abdul Hye, Isabelle Bos, Stephanie J. B. Vos, Rik Vandenberghe, Charlotte E. Teunissen, Mara ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin, Jill Richardson, Ellen De Roeck, Sebastiaan Engelborghs, Kristel Sleegers, Régis Bordet, Lorena Ramit, Petronella Kettunen, Magda Tsolaki, Frans R.J. Verhey, Daniel Alcolea, Alberto Lleó, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund‐Levi, Lutz Frölich, Valerija Dobričić, Giovanni B. Frisoni, José Luís Molinuevo, Anders Wallin, Julius Popp, Pablo Martínez‐Lage, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter Jelle Visser, Simon Lovestone, Cristina Legido‐Quigley,
Abstract Introduction Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers. Methods This study analyzed samples from 242 cognitively normal (CN) people and 115 with AD‐type dementia utilizing plasma metabolites (n = 883). Deep Learning (DL), Extreme Gradient Boosting (XGBoost) and Random Forest (RF) were used to differentiate AD from CN. ...
Tópico(s): Diet and metabolism studies
2019 - Elsevier BV | Alzheimer s & Dementia Translational Research & Clinical Interventions
Rodrigo Papa‐Gobbi, Alba Bueno, Javier Serradilla, Paloma Talayero, Pablo Stringa, B. Pascual-Miguel, A Alcolea-Sánchez, Rocío González‐Sacristan, Ane Miren Andrés, Manuel López‐Santamaría, Martı́n Rumbo, Esther Ramos Boluda, F Hernández,
... to disclose. Papa-Gobbi, Rodrigo; Talayero, Paloma; Stringa, Pablo; and Rumbo, Martín involved in manuscript preparation. Papa-Gobbi, Rodrigo involved in figures preparation. Pascual-Miguel, Bárbara involved in flow cytometry analysis of SARS-CoV-2-specific T cells. Papa-Gobbi, Rodrigo; Alcolea-Sánchez, Alida; and González-Sacristan, Rocío involved in ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Wiley | Transplant Infectious Disease
Adelina Orellana, Pablo García‐González, Sergi Valero, Laura Montrreal, Itziar de Rojas, Isabel Hernández, Maitée Rosende‐Roca, Liliana Vargas, Juan Pablo Tartari, Ester Esteban‐De Antonio, Urszula Bojaryn, Leire Narvaiza, Emilio Alarcón‐Martín, Montserrat Alegret, Daniel Alcolea, Alberto Lleó, Lluís Tárraga, Vanesa Pytel, Amanda Cano, Marta Marquié, Merçé Boada, Agustı́n Ruiz,
Clinical diagnosis of Alzheimer's disease (AD) increasingly incorporates CSF biomarkers. However, due to the intrinsic variability of the immunodetection techniques used to measure these biomarkers, establishing in-house cutoffs defining the positivity/negativity of CSF biomarkers is recommended. However, the cutoffs currently published are usually reported by using cross-sectional datasets, not providing evidence about its intrinsic prognostic value when applied to real-world memory clinic cases. ...
Tópico(s): Functional Brain Connectivity Studies
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Ane Miren Andrés, José Luis Encinas, Alba Galán, Javier Serradilla, Karla Estefanía, Rocío González Sacristán, Alida Alcolea, Pilar Serrano Fernández, Belén Estebánez, Iñigo Velasco Leon, Paula I. Burgos, Álvaro González, Bunty Ramchandani, Belén Calderón, Cristina Verdú, Esperanza Jimenez, Paloma Talayero, Pablo Stringa, Itziar de la Peña Navarro, Esther Ramos Boluda, F Hernández,
The current shortage of pediatric multivisceral donors accounts for the long time and mortality on the waiting list of pediatric patients. The use of donors after cardiac death, especially after the outbreak of normothermic regional perfusion, has increased in recent years for all solid organs except the intestine, mainly because of its higher susceptibility to ischemia-reperfusion injury. We present the first literature case of multivisceral donors after cardiac death transplantation in a 13-month- ...
Tópico(s): Liver Disease and Transplantation
2023 - Elsevier BV | American Journal of Transplantation
Alberto Lleó, Raúl Núñez‐Llaves, Daniel Alcolea, Cristina Chiva, Daniel Balateu-Paños, Martí Colom‐Cadena, Gemma Gomez‐Giro, Laia Muñoz, Marta Querol‐Vilaseca, Jordi Pegueroles, Lorena Rami, Albert Lladó, José Luís Molinuevo, Mikel Tainta, Jordi Clarimón, Tara L. Spires‐Jones, Rafael Blesa, Juan Fortea, Pablo Martínez‐Lage, Raquel Sánchez‐Valle, Eduard Sabidó, Àlex Bayés, Olivia Belbin,
A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology that precedes neuronal death and symptom onset, would be a much-needed prognostic biomarker. With direct access to the brain interstitial fluid, the cerebrospinal fluid (CSF) is a potential source of synapse-derived proteins. In this study, we aimed to identify and validate novel CSF biomarkers of synapse loss in AD. Discovery: Combining shotgun proteomics of the CSF with an exhaustive search of the literature ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - Elsevier BV | Molecular & Cellular Proteomics
A. Alcolea, Ascensión Hernández Martínez, Pablo Laguna, José A. Altabás, T. Pollán, S. J. Vicente, A. Roy,
The FAMA (Fine granularity Advanced Multiprocessor Architecture), currently being developed in the Department of Electrical Engineering and Computer Science of the University of Zaragoza, is an SIMD array architecture optimized for computer-vision applications. Because of its high cost-effectiveness, it is a very interesting alternative for industrial systems. Papers describing the processor element of FAMA have been submitted to several conferences; this paper focuses on the rest of components that ...
Tópico(s): CCD and CMOS Imaging Sensors
1987 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Carlos Cachán-Alcolea, Juan Pablo Mateos Abarca, Antonio Vaquerizo Mariscal,
Noticias falsas, afirmaciones engañosas, bulos, medias verdades, mentiras… Para vencer al virus de la desconfianza, alimentado por las falsas noticias de salud que circulan por internet -y más en tiempos de coronavirus-, la receta es acudir a los expertos, como son los científicos y los profesores, actividad que comparten Hipócrates, Agustín de Hipona y Kepler. Desde nuestro punto de vista, los tres están entre esas fuentes de prestigio para informarse bien de los acontecimientos y descubrir las ...
Tópico(s): Communication and COVID-19 Impact
2020 - Carlos III University of Madrid | REVISTA ESPAÑOLA DE COMUNICACIÓN EN SALUD
Jin Xu, Rebecca Green, Min Kim, Jodie Lord, Amera A. Ebshiana, Sarah Westwood, Alison L. Baird, Alejo Nevado‐Holgado, Liu Shi, Abdul Hye, Stuart G. Snowden, Isabelle Bos, Stephanie J. B. Vos, Rik Vandenberghe, Charlotte E. Teunissen, Mara ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin, Jill Richardson, Ellen De Roeck, Sebastiaan Engelborghs, Kristel Sleegers, Régis Bordet, Lorena Rami, Petronella Kettunen, Magda Tsolaki, Frans R.J. Verhey, Daniel Alcolea, Alberto Lleó, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund‐Levi, Lutz Frölich, Valerija Dobričić, Giovanni B. Frisoni, José Luís Molinuevo, Anders Wallin, Julius Popp, Pablo Martínez‐Lage, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter Jelle Visser, Simon Lovestone, Petroula Proitsi, Cristina Legido‐Quigley,
Background: physiological differences between males and females could contribute to the development of Alzheimer’s Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. Methods: We explored whether sex modifies the association of 540 plasma metabolites with AD endophenotypes including diagnosis, cerebrospinal fluid (CSF) biomarkers, brain imaging, and cognition using regression analyses for 695 participants (377 females), followed by sex-specific pathway ...
Tópico(s): Stress Responses and Cortisol
2021 - Multidisciplinary Digital Publishing Institute | Biomedicines
Pedro J. Alcolea, Jaime Larraga, Daniel Rodríguez-Martín, Ana Alonso, Francisco J. Loayza, José M. Rojas, Silvia Ruiz-García, Andrés Louloudes-Lázaro, Ana B. Carlón, Pedro J. Sánchez‐Cordón, Pablo Nogales-Altozano, Natalia Redondo, Miguel Manzano, Daniel Lozano, Jesús Palomero, María Montoya, Maria Vallet‐Regí, Verónica Martı́n, Noemı́ Sevilla, Vicente Larraga,
SARS-CoV-2 vaccines currently in use have contributed to controlling the COVID-19 pandemic. Notwithstanding, the high mutation rate, fundamentally in the spike glycoprotein (S), is causing the emergence of new variants. Solely utilizing this antigen is a drawback that may reduce the efficacy of these vaccines. Herein we present a DNA vaccine candidate that contains the genes encoding the S and the nucleocapsid (N) proteins implemented into the non-replicative mammalian expression plasmid vector, pPAL. ...
Tópico(s): Viral gastroenteritis research and epidemiology
2022 - Frontiers Media | Frontiers in Immunology