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Documentos governamentais Acesso aberto

... in colonial society. Includes two texts by Juan Pérez de Menacho, a famous Jesuit theologian of the first half of the seventeenth century. The collection comes from the archive of the College of San Pablo in Lima. n.d.

0000 - Gale Group | World Scholar Latin America

Artigo Acesso aberto Revisado por pares

Pablo Pérez-Lantero,

... the Convex Hull of Stochastic Points Get access Pablo Pérez-Lantero Pablo Pérez-Lantero * Escuela de Ingeniería Civil en Informática, Universidad de Valparaíso, Valparaiso, Chile * Corresponding author: pablo.perez@uv.cl Search for other works by this ...

Tópico(s): Point processes and geometric inequalities

2016 - Oxford University Press | The Computer Journal

Documentos governamentais Acesso aberto

... in colonial society. Includes two texts by Juan Pérez de Menacho, a famous Jesuit theologian of the first half of the seventeenth century. The collection comes from the archive of the College of San Pablo in Lima. n.d.

0000 - Gale Group | World Scholar Latin America

Artigo Revisado por pares

Juan Pablo Pérez Sáinz, Katharine Andrade–Eekhoff,

... to decrease image size Additional informationNotes on contributorsJuan Pablo Pérez SáinzJuan Pablo Pérez Sáinz is a researcher with the Facultad Latinoamericana ... at FLACSO in El Salvador.Katharine Andrade–EekhoffJuan Pablo Pérez Sáinz is a researcher with the Facultad Latinoamericana ...

Tópico(s): International Business and FDI

2003 - Taylor & Francis | NACLA Report on the Americas

Jornais Acesso aberto

Adrian Hill, Sally Brock, Allan Palmer, Professor Gideon Garter, Lucinda Lambton, Ed Owen, Meena Pathak, Barry Kane, Alastair McCall, Will Alsop, Neil Wormald, Henry Engelhardt, Emma smith, Mark Makepeace, Dominic Bradbury, Charles Murray, Martin James, Pope John Paul, Rosie Millard, Marle Colvin, John Mortimer, David Hewson, Kamil Tchorek, Barry Howcombe, H Cameron Barnes, Hugh Canning, Andrew Stone, Camilla Hagen, Ed Mayo, Sarah Dempster, Gabriella Fulda, Peter Kellner, Elizabeth Clarke, Tom Burke, Ringo Starr, Martin Taylor, Nicola Bannister, Ali Rifat, Kint, Giles Hattersley, Shelley Von Strunckel, Christopher Morgan, Peter O'reilly, Robbie Hudson, Emma Smith, David Binnie, Nick Rennison, Robert Ballantyne, Bryan Appleyard, John Elliott, P N, Richard Brooks Arts Editor, Geraldine Stratford, Sir Cameron MacKintosh, Dan Box, Stephen Hoare, Lord Brocket, Matthew Campbell, Michael Glyn, Nick Fielding, Peter Munro, Anna Hodgekiss, Graham Norwood, David Budworth, Christopher Eccleston, M Mahida, Jeffrey Podolsky, Stewart Mitchell, Earl Spencer, Mike Hammond, Sarah Baxter, Elena Yoncheva, Dr L Illis Editor, Jason Dawe, Sian Griffiths, Jonathan Northcroft, John Roberts, Matthew Wall, Roland white, Charles, Matthew Elliott, Chris Gearing, Colin Brennan, William Lewis Business Editor, Andrew Longmore, Chryss Goulandris, Hiroto Abe, Lucy Hughes-Hallett, Andrew Sullivan, Clive Davis, Nicholas Alexander, Joanna David, Tristram Hunt, Sir Alan Sugar, Stuart Barnes, Peter Jones, Victoria Segal, Edward Porter, Phil Spencer, Howard Clark, Jeanette Winterson, Daniel Johnson, Jeff Potter, Catherine Zeta-Jones, Andrew Thomas, Brendan Bourne, Robin Scott-Elliot, D Wild, Steve Boyd, Sue Fox, John Follain, Richard Brooks, Stuart Andrews, David Leppard, Lord Saatchi, Sir Tony O'Reilly, Lois Rogers, Alan Combes, Bryan Owram, David Cracknell, Tim, Diana Wright, Alice Douglas, Barry Flatman, Andrew Neil, Natalie Graham, Stephen Armstrong, Bethan Cole, Ray Hutton, M E, Fay Weldon, Dileep Premachandran, Michael Moritz, A A Gill, F Glasgow, Brian Glanville, David Sumner Smith, Jeremy Langmead, Daniel Emery, Nigel Powell, Lucy Neville-Rolfe Corporate and Legal Affairs Director, Brian Doogan, Ben Dowell, John Aizlewood, John Cornwell, Jeremy Lazell, Fanny Sunesson, Jonathan Futrell, Hugh Pearman, S Dickson, Rachel De Thame, Richard Lewis, Helen Stewart, John Dugdale, Hendry, Vittorio Merloni Chairman, William Kay, Barbara Hall, Ricky Gervais, Rob Hughes, John Peter, William Morris, Ivo Tennant, David Smith, Carol Homden, Nick Pitt, Tom Walker, Dipesh Gadher Transport Correspondent, Stephen Marks, Adrian Furnham, Jenny Kastner, H C, Annabel Karmel, Hugh Mcllvanney, Stewart Lee, Peter Conradi, Michael Portillo, Patricia Nicol, Richard Fletcher, Charlie Higson, David Walsh Chief Sports Writer, Sarah-Kate Templeton, Paul Owen, Sami Joseph, Paul Kimmage, Chris Woodhead, Naomi Hiller, Daniel McLaughlin, Mark Edwards, Rachel Bridge, Susan Clark, Glenda Cooper, John Paul, John O'Connor, David Baddiel, Jonathan King, Michael Gambon, Raymond Keene, Zoe Brennan, Waldemar Januszezak, Meera Syal, Stephen Bleach, Louise Armitstead, Nick Cain, Trevor Lewis, Robert Edwarda, Victoria O'brien, Roland White, Abul Taher, Amrit Dhillon, Richard Rae, Jon Ungoed-Thomas, David Varney, Michael Sheridan, Philip Beresford, John Waples, Hunter Davies, Mike Rake, Andrew Lycett, Simon Jenkins, Stephen Pettitt, Jack Baber, Andrew Frankel, Joe Lovejoy, Toni Mascolo, Dan Cairns, Manish Agarwal, David Smith Economics Editor, Chris Feetenby, K Goodwin, Simon Howard, Dominic Rushe, Karen Robinson, Chris Hutchens, Dan Cruickshank, Russ Dewar, Fred Redwood, Sir Ludovic Kennedy, Abe Hayeem, Helen Davies, George Plant, Christopher Somerville, Frank Whitford, Nicolette Jones, Kathryn Cooper, Martin Brundle, Nick Skelton, Andrew Porter, Tony Allen-Mills, Simon Wilde, Michael Douglas, Ariel Leve, Robert Winnett, Irwin Stelzer, Robert Hewison, Peter Wilson, David Dougill, Frank Graham, Dara O'Briain, Rob Maul, Paul Forsyth, Nick Johnson, Philip Smith, Nick Middleton, Bob Walker, Ben Hogan, David Stow, Wendy Sloane, Paul Parker, Greg Struthers, Jon Lee Anderson, Mark Green, Ed Hughies, Jasper Gerard, Paul Driver, Johnny Shentall, Ian Hawkey, Kit Kemp, Mark Mudie, Hans Rausing, Gordon Potter, Judi Bevan, Phil Baker, Christina Lamb, Cosmo Landesman, Peter Hall, Helen Hawkins, Dominic O'Connell, Adrienne Connors, Caroline Donald, Francesca Anslow, Colin McDowell, Ron Clarke, Jenny Bromage, Shane Watson, Ros Beck, Hilary Spurling, Valerie Singleton, John Harlow, Mark Kleinman, Nick Laird, Charles Saatchi, David Newbery, Deirdre Fernand, Jessica Bown, Natalia Marshall, Sally Kinnes, Naomi Caine, Minette Marrin, George Davis, Andrew Davidson, Pete Oliver, John Alzlewood, Janie Omorogbe, Emma Sanchez, Matthew Goodman, India Knight, Dom Castle, Cindy Crawford,

... Steve Bell 29: Mobile phones, 71=, £6m Juan Pablo Angel 29: Football, 85=, £5m Sally Croker-Poole: ...

2005 - Gale Group | Sunday Times HA GDA

Carta Revisado por pares

José López‐Miranda, Pablo Pérez‐Martínez,

... for more papers by this authorPablo Perez-Martinez, Pablo Perez-Martinez Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia ... for more papers by this authorPablo Perez-Martinez, Pablo Perez-Martinez Lipids and Atherosclerosis Unit, IMIBIC/Reina Sofia ...

Tópico(s): Obesity, Physical Activity, Diet

2013 - Wiley | Clinical Endocrinology

Jornais Acesso aberto

Maria Joseph, Waldemar Januszczak, John Dugdale, Steve Pittard, Collin McDOWELL'S, Barbara Hall, Harry Tidsley, Frank Parker, David Mills, Peter Whittle, Helen Davies, Sean O'Brien, Sally Brock, Mike Pffanz, Rob Hughes, Amanda Ursell, Jim Brotton, Jonathan Miller, S Waddington, Andrew Longmore, Lesley White, Nick Rufford, Gareth Walsh, Frank Whitford, Ivo Tennant, Caroline Brannigan, Ferdinand Mount, Kathryn Cooper, William Lewis, P D, David Smith, Darren Campbell, Tim Richards, P P, David Cracknell Political Editor, Nick Pitt, Dr Conor Carr, Neil Wormald, E P, David James Smith, Andrew Sullivan, Clive Davis, Kate Reardon, K R, Ateh Damachi, Sally Brown, Jeremy Smith, A C, Gideon Garter Professor, Tony Allen-Mills, Simon Wilde, Martin James, Jonathan Ungoed-Thomas, Tristram Hunt, Anthony Sattin, Robert Winnett, Peter Koeing, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Jeremy Seal, Adrian Furnham, Duncan Farmer, Peter Wilson, Rosie Millard, Joey Dunlop, Robert Hewison, David Dougill, Christopher Hart, Jim Piatt-Higgins, Frank Graham, John Waples Deputy Business Editor, Stewart Lee, H C, Saky Kinnes, David Hewson, Cally Law, Jim Dougal, Hugh Canning, Burlington Bertle, Hugh Mcllvanney, Geraldine Hackett Education Correspondent, Peter Bulloch, Jeremy Clarkson, Andrew Stone, Margarette Driscoll, Peter Conradi, Edward Porter, Ryan Gilbey, Peter Upton, David Connett, Michael Portillo, Eileen Wheelans, David Cairns, Anthony Peregrine, Alan Brownjohn, Sarah Dempster, Helen Kenny, Dave Pollard, Kevin Jackson, Shirley Rose, Paul Metcalfe, Richard Fletcher, Ranulph Fiennes, Greg Struthers, James Delingpole, Adam Nathan, Jeremy Guscott, Charlie Higson, Paul Durman City Editor, Jason Dave, Tom Provan, Robin Scott-Elliot, Stuart Wavell, Roger Eglin, Maggie Gee, Paul Donovan, Norman Miller, Smily Lloyd, Adam Nathan Defence Correspondent, Vincent Crump, Michael Howard, Giles Hattersley, Chris Woodhead, Monsieur Mangetout, Lucinda Kemeny, Jasper Gerard, Paul Driver, Imogen Brewer, Nicholas Hellen, Richard Brooks, Shelley Von Strunckel, Stuart Andrews, Alex Clark, David Leppard, Oleg Gordievsky, Paul Durman, Peter Clarke Founder, Alicia Wyllie, Dave Hannigan, Richard Girling, Mark Edwards, Buffy Reid, Trevor Hamley, Susan Clark, Milly Chen, Charlotte Burgess, Nigel Jay, Nicholas Alexander Faldo, Blower, Robert Lacey, T Ellison, Partricia Nicol, Lois Rogers, Richard Young, Raymond Keene, Douglas Alexander, David Cracknell, Cosmo Landesman, Zoe Brennan, Peter Hall, Robbie Hudson, Diana Wright, Dominic O'Connell, Andrew Holgate, Barry Flatman, Uzi Mahnaimi, Nick Cain, Louise Armitstead, Councillor James Scott, Adrienne Connors, Michael Wright, Natalie Graham, I C, Keith Cameron, Tim Moorey, Caroline Donald, Dominic Rushe, Hugh McManners, Jemma Harvey, Fiona Terry, David Walsh, John Bowis MEP, Scott Johnstone, Mark Taha, Colin McDowell, Bryan Appleyard, Stephen Armstrong, Lennox Lewis, John Elliott, Nick MacKinnon, Emily Pritchard, Christopher Goodwin, M L, Bethan Cole, Victoria O'brien, R W Johnson, Roland White, Tony Allen-Milles, Shane Watson, Amrit Dhillon, Maurice Chittenden, Mark Haddon, David George, Judi Rouse Edwards, Jason Lloyd-Evans, Victoria Segal, Judith O'Reilly, David Rees, Mark Franchetti, Mel Webb, Martin Ivens, Richard Rae, Ray Hutton, Donald Sadler, Jason Gardener, Lizzie Pountney, Clive Lloyd, Michael Sheridan, Dan Box, Clare Francis, Colin Yates, John Crossland, John Harlow, Brian Smyth, Bethan Ryder, Barry Collins, Michael Collins, Huw Benyon, John Waples, Bill Clinton, Jeremy Hart, Suzi Perry, Geoff Tibballs, Nick Haysom, Matthew Campbell, Trevor Broadley, Marc Zakian, A A Gill, John Carey, Tom Robbins, Mary Braid, Stephen Pettitt, Claudia Croft, Jonathan Carr-Brown, Will Iredale, Jonathan Leake Science Editor, Rob Clark, Kate Bleasdale, Maria McErlane, R H, Shirely Mazzard, Hugh Barnard, Naomi Caine, Nigel Powell, David Wickers, Daniel Emery, Brian Doogan, Michael Clower, Ben Dowell, Minette Marrin, Neil White, Mark Hodson, Andrew Frankel, Graham Norwood, Ken Lunn, David Milis, David Budworth, Ed Owen Madrid, William Lewis Business editor, Andrew Davidson, Hugh Pearman, Maurice O'Blen, Steve West, Tony Perrottet, Dan Cairns, Sebastian Smith, M Mistry, David Smith Economics Editor, Tom Deveson, Sarah Baxter, Joanna Simon, David Robertson, Matthew Goodman, India Knight, Anthony Millar, Simon Howard, Tom Norrington-Davies, Natasha Shishmanian, Richard Lewis, Sian Griffiths, Karen Robinson, Helen Stewart,

... Mattgoss Speed Demon! Colombian Formula One driver Juan Pablo Montoya talks to Funday as he promotes Hot ... Acosta's Tocororo, David Dougill finds Jose Oduardo Perez ready to fill his Cuban mentor's shoes ...

2004 - Gale Group | Sunday Times HA GDA

Artigo Revisado por pares

Pablo Pérez‐Alonso,

... giant cells diagnosed by fine-needle aspiration cytology Pablo Pérez-Alonso, M.D., Corresponding Author Pablo Pérez-Alonso, M.D. [email protected] Service of Pathology, ... 28034, SpainSearch for more papers by this author Pablo Pérez-Alonso, M.D., Corresponding Author Pablo Pérez-Alonso, M.D. [email protected] Service of Pathology, ...

Tópico(s): Breast Cancer Treatment Studies

2011 - Wiley | Diagnostic Cytopathology

Artigo Acesso aberto Revisado por pares

Javier Delgado‐Lista, Juan F. Alcalá‐Díaz, José D. Torres‐Peña, Gracia M. Quintana‐Navarro, Francisco Fuentes, Antonio García‐Ríos, Ana M. Ortiz-Morales, Ana I. Gonzalez-Requero, Ana I. Perez‐Caballero, Elena M. Yubero‐Serrano, Oriol Alberto Rangel-Zúñiga, Antonio Camargo, Fernando Rodríguez-Cantalejo, Fernando Lopez‐Segura, Lina Badimón, José M. Ordovás, Francisco Pérez‐Jiménez, Pablo Pérez‐Martínez, José López‐Miranda, Juan F. Alcalá‐Díaz, Yolanda Almaden Peña, Enrique Aranda, Antonio P. Arenas-de Larriva, Lina Badimón, Juan J. Badimón, Ángeles Blanco‐Molina, Ruth Blanco-Rojo, Julia Bolivar-Muñoz, Javier Caballero‐Villarraso, Antonio Camargo, Javier Emílio Lazo Chica, Andreea Corina, Juan Criado-García, Cristina Cruz‐Teno, Antonio Daponte, Eduardo de Teresa Galván, Nieves Delgado‐Casado, Javier Delgado‐Lista, Ramón Estruch, Juan Marcelo Fernández, Carolina Fernández-Gandara, Francisco Fuentes, Sonia García‐Carpintero, Antonio García‐Ríos, Francisco Gómez-Delgado, Angela Gomez-Garduño, Purificación Gómez-Luna, Maria J. Gómez-Luna, Lorena González-Guardia, Ana I. Gonzalez-Requero, Francisco M. Gutierrez‐Mariscal, Carmen Haro, Rosa Jiménez-Lucena, Ana Isabel Jiménez-Morales, Ana Leon‐Acuña, José López‐Miranda, Fernando Lopez‐Segura, Carmen Marín-Hinojosa, María E. Meneses, Dolores Mesa-Luna, Maria N Moya-Garrido, Ignacio Muñoz-Carvajal, Vanessa Navarro-Martos, Juan J Ochoa, José M. Ordovás, Juan A Ortiz-Minuesa, Ana M. Ortiz-Morales, Manuel Pan, Patricia J. Peña‐Orihuela, Ana I. Perez‐Caballero, Isabel Perez-Corral, Francisco Pérez‐Jiménez, Pablo Pérez‐Martínez, Francesc X Pi-Sunyer, Gracia M. Quintana‐Navarro, Irene Ramirez-Lara, Oriol Alberto Rangel-Zúñiga, Fernando Rodríguez‐Artalejo, Fernando Rodríguez-Cantalejo, Miguel A. Romero, Irene Roncero‐Ramos, Juan Ruano, Joaquín Ruiz de Castroviejo, Pablo Sánchez‐Villegas, José Suárez de Lezo, José Suárez de Lezo, José D. Torres‐Peña, Cristina Vals‐Delgado, Roberto Valverde, Francesco Visioli, Elena M. Yubero‐Serrano,

Mediterranean and low-fat diets are effective in the primary prevention of cardiovascular disease. We did a long-term randomised trial to compare the effects of these two diets in secondary prevention of cardiovascular disease.The CORDIOPREV study was a single-centre, randomised clinical trial done at the Reina Sofia University Hospital in Córdoba, Spain. Patients with established coronary heart disease (aged 20-75 years) were randomly assigned in a 1:1 ratio by the Andalusian School of Public Health ...

Tópico(s): Consumer Attitudes and Food Labeling

2022 - Elsevier BV | The Lancet

Artigo Acesso aberto Revisado por pares

Arantxa Pérez‐García, Pablo Pérez‐Durán, Thomas Wossning, Isora V. Sernández, Sonia M. Mur, Marta Cañamero, Francisco X. Real, Almudena R. Ramiro,

... Spain Search for more papers by this author Pablo Pérez-Durán Pablo Pérez-Durán B Cell Biology Lab, Centro Nacional de ... Spain Search for more papers by this author Pablo Pérez-Durán Pablo Pérez-Durán B Cell Biology Lab, Centro Nacional de ... by this author Author Information Arantxa Pérez-García1, Pablo Pérez-Durán1,4, Thomas Wossning1,5, Isora V Sernandez1, ...

Tópico(s): Lymphoma Diagnosis and Treatment

2015 - Springer Nature | EMBO Molecular Medicine

Artigo Acesso aberto Revisado por pares

Javier F. Mariscotti, Francisco García‐del Portillo, M. Graciela Pucciarelli,

... E. Nedjari H. Nordsiek G. Novella S. de Pablos B. Perez-Diaz J.C. Purcell R. Remmel B. Rose ... E. Nedjari H. Nordsiek G. Novella S. de Pablos B. Perez-Diaz J.C. Purcell R. Remmel B. Rose ... E. Nedjari H. Nordsiek G. Novella S. de Pablos B. Perez-Diaz J.C. Purcell R. Remmel B. Rose ...

Tópico(s): Botanical Research and Applications

2009 - Elsevier BV | Journal of Biological Chemistry

Artigo Acesso aberto Revisado por pares

Hélène Réglier‐Poupet, Claude Fréhel, Iharilalao Dubail, Jean‐Luc Béretti, Patrick Berche, Alain Charbit, Catherine Raynaud,

... E. Nedjari H. Nordsiek G. Novella S. de Pablos B. Perez-Diaz J.C. Purcell R. Remmel B. Rose ... E. Nedjari H. Nordsiek G. Novella S. de Pablos B. Perez-Diaz J.C. Purcell R. Remmel B. Rose ... E. Nedjari H. Nordsiek G. Novella S. de Pablos B. Perez-Diaz J.C. Purcell R. Remmel B. Rose ...

Tópico(s): Escherichia coli research studies

2003 - Elsevier BV | Journal of Biological Chemistry

Artigo Revisado por pares

Elena M. Yubero‐Serrano, Javier Delgado‐Lista, Juan F. Alcalá‐Díaz, Antonio García‐Ríos, Ana I. Perez‐Caballero, Ruth Blanco-Rojo, Francisco Gómez-Delgado, Carmen Marı́n, Francisco J. Tinahones, Javier Caballero‐Villarraso, José M. Ordovás, Ben van Ommen, Francisco Pérez‐Jiménez, Pablo Pérez‐Martínez, José López‐Miranda,

Background and aims Patients with coexisting coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) are at high risk of cardiovascular recurrence, however, it is not well established whether they exhibit an increased intima-media thickness of both common carotid arteries (IMT-CC). Furthermore, whether this relationship is inherent to T2DM or depends on glycemic control has not been tested in large cohorts. Our aim was to determine whether clinical categories and/or analytical markers of glucose ...

Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins

2016 - Elsevier BV | Atherosclerosis

Artigo Acesso aberto Revisado por pares

Eva Talavera-Garcia, Javier Delgado‐Lista, Antonio García‐Ríos, Nieves Delgado‐Casado, Purificación Gómez-Luna, Angela Gomez-Garduño, Francisco Gómez-Delgado, Juan F. Alcalá‐Díaz, Elena M. Yubero‐Serrano, Carmen Marı́n, Ana I. Perez‐Caballero, Francisco Fuentes, Antonio Camargo, Fernando Rodríguez-Cantalejo, Francisco J. Tinahones, José M. Ordovás, Francisco Pérez Jiménez, Pablo Pérez‐Martínez, José López‐Miranda,

Background Recent data suggest that the presence of associated metabolic abnormalities may be important modifiers of the association of obesity with a poorer prognosis in coronary heart disease. We determined the influence of isolated overweight and obesity on carotid intima media thickness (IMT-CC), and also assessed whether this influence was determined by the presence of metabolic abnormalities. Methods 1002 participants from the CordioPrev study were studied at entry. We determined their metabolic ...

Tópico(s): Cardiovascular Function and Risk Factors

2016 - Public Library of Science | PLoS ONE

Revisão Revisado por pares

Antonio García‐Ríos, José D. Torres‐Peña, Francisco Pérez‐Jiménez, Pablo Pérez‐Martínez,

Cardiovascular disease (CVD) continues to be the major cause of death in the developed countries. Moreover, the cardiovascular risk factors leading towards the development of CVD, mainly type 2 diabetes and obesity, are on the rise. The current preventive and therapeutic management, centred on the control of traditional risk factors, is clearly not enough to stop this pandemic. Therefore, the search for new biomarkers in CVD is a priority in most clinical research programs. Currently, interest in ...

Tópico(s): Cardiovascular Health and Risk Factors

2017 - Bentham Science Publishers | Current Pharmaceutical Design

Revisão Acesso aberto Revisado por pares

Jasenka Zubcevic, Monica M. Santisteban, Teresa Pitts, David M. Baekey, Pablo D. Pérez, Donald C. Bolser, Marcelo Febo, Mohan K. Raizada,

... Monica M. Santisteban, Teresa Pitts, David M. Baekey, Pablo D. Perez, Donald C. Bolser, Marcelo Febo and Mohan K. ... College of Veterinary Medicine, University of Florida, Gainesville. , Pablo D. PerezPablo D. Perez From the Departments of Physiology and Functional Genomics ( ...

Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms

2014 - Lippincott Williams & Wilkins | Hypertension

Artigo Acesso aberto Revisado por pares

Javier Delgado‐Lista, Francisco Pérez‐Jiménez, Juan Ruano, Pablo Pérez‐Martínez, Francisco Fuentes, Juan Criado-García, Laurence D. Parnell, Antonio García‐Ríos, José M. Ordovás, José López‐Miranda,

The APOA1/C3/A4/A5 gene cluster encodes important regulators of fasting lipids, but the majority of lipid metabolism takes place in the postprandial state and knowledge about gene regulation in this state is scarce. With the aim of characterizing possible regulators of lipid metabolism, we studied the effects of nine single nucleotide polymorphisms (SNPs) during postprandial lipid metabolism. Eighty-eight healthy young men were genotyped for APOA1 -2630 (rs613808), APOA1 -2803 (rs2727784), APOA1 -3012 ( ...

Tópico(s): Peroxisome Proliferator-Activated Receptors

2009 - Elsevier BV | Journal of Lipid Research

Artigo Acesso aberto Revisado por pares

Toshiko Tanaka, José M. Ordovás, Javier Delgado‐Lista, Francisco Pérez‐Jiménez, Carmen Marı́n, Pablo Pérez‐Martínez, Purificación Gómez, José López‐Miranda,

Peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-dependent transcription factor that plays a key role in lipid and glucose homeostasis. This study evaluated whether variants of PPARalpha are associated with postprandial lipemia. Subjects were given a single fat load composed of 60% calories as fat, 15% as protein, and 25% as carbohydrate. Blood was drawn every hour from baseline to 6 h, then every 2.5 h to 11 h to determine triglyceride (TG) levels. The minor allele of the ...

Tópico(s): Adipose Tissue and Metabolism

2007 - Elsevier BV | Journal of Lipid Research

Revisão Revisado por pares

Francisco Pérez‐Jiménez, Juan Ruano, Pablo Pérez‐Martínez, Fernando Lopez‐Segura, José López‐Miranda,

Olive oil is the most representative food in the traditional Mediterranean diet and its most important source of MUFA. The healthy benefits of MUFA-rich diets on plasma cholesterol levels, were the first to generate interest in this dietary model. In addition to the benefits conferred by its lipids, olive oil has other biological effects, some of them also related to MUFA. However, most recent studies have shown that there are a number of properties that depend on, or are potentiated by, the consumption ...

Tópico(s): Fatty Acid Research and Health

2007 - Wiley | Molecular Nutrition & Food Research

Artigo Acesso aberto Revisado por pares

Rafael Moreno‐Luna, Francisco Pérez‐Jiménez, Carmen Marı́n, Pablo Pérez‐Martínez, Purificación Gómez, Yolanda Jiménez, Javier Delgado‐Lista, Juan Antonio Moreno, Toshiko Tanaka, José M. Ordovás, José López‐Miranda,

Background: Apolipoprotein A5 (APOA5) plays an important role in plasma triacylglycerol (TG) homeostasis. Five polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c.1259T>C) in the APOA5 gene define three common haplotypes (APOA5*1, APOA5*2, and APOA5*3) in Caucasian individuals. Our aim was to determine whether these haplotypes could modulate the postprandial response in young healthy males.

Tópico(s): Lipid metabolism and biosynthesis

2007 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism

Artigo Acesso aberto Revisado por pares

Toshiko Tanaka, Javier Delgado‐Lista, José López‐Miranda, Francisco Pérez‐Jiménez, Carmen Marı́n, Pablo Pérez‐Martínez, Purificación Gómez, José M. Ordovás,

The scavenger receptor class B type I (SCARB1) is a cell surface glycoprotein that plays a key role in reverse cholesterol transport. A polymorphism in exon 8 (c.1119C>T) has been associated with fasting HDL- and LDL- cholesterol concentrations in Caucasian populations. This study evaluated whether this variant is associated with postprandial lipemia in 59 normolipidemic males. After an overnight fast, the subjects were given a single fat load comprising 60% of energy as fat, 15% as protein, and 25% ...

Tópico(s): Cholesterol and Lipid Metabolism

2007 - Elsevier BV | Journal of Nutrition

Artigo Acesso aberto Revisado por pares

Javier Delgado‐Lista, Francisco Pérez‐Jiménez, Toshiko Tanaka, Pablo Pérez‐Martínez, Yolanda Jiménez, Carmen Marı́n, Juan Ruano, Laurence D. Parnell, José M. Ordovás, José López‐Miranda,

Apolipoprotein (Apo) A-II is an apolipoprotein with an unknown role in lipid metabolism. It has been suggested that the presence of the less frequent allele of a single nucleotide polymorphism (Apo A-II -265T/C, rs5082) reduces the transcription rate of Apo A-II and enhances VLDL postprandial clearance in middle-aged men. To further investigate the role of Apo A-II -265T/C on lipid metabolism, we studied 88 normolipidemic young men. The participants were given a fatty meal containing 1 g fat and 7 mg ...

Tópico(s): Lipoproteins and Cardiovascular Health

2007 - Elsevier BV | Journal of Nutrition

Artigo Acesso aberto Revisado por pares

Juan M. Bueno, Emilio J. Gualda, Anastasia Giakoumaki, Pablo Pérez‐Merino, Susana Marcos, Pablo Artal,

Purpose.: To investigate changes in the morphology of the corneal stroma after collagen cross-linking (CXL) treatment in bovine and porcine eyes using a nonlinear microscope providing both two-photon excitation fluorescence (TPEF) and second harmonic generation (SHG) corneal images. Methods.: Freshly enucleated eyes were imaged using a tomographic nonlinear imaging method that was highly suitable to track temporal changes in corneal structures. CXL (riboflavin instillation plus UV irradiation) was applied ...

Tópico(s): Glaucoma and retinal disorders

2011 - Cadmus Press | Investigative Ophthalmology & Visual Science

Artigo Acesso aberto Revisado por pares

Juan Antonio Moreno, Francisco Pérez‐Jiménez, Carmen Marı́n, Pablo Pérez‐Martínez, Rafael Moreno‐Luna, Purificación Gómez, Yolanda Jiménez, Juan Antonio Pacheco Paniagua, Denis Lairon, José López‐Miranda,

Insulin sensitivity (IS) is determined by genetic and environmental factors, including diet. The apoE gene promoter −219G/T polymorphism is associated with coronary heart disease and increased postprandial triacylglycerol-rich lipoprotein concentration, circumstances related to insulin resistance. Thus, our aim was to determine whether this polymorphism modified the IS response to dietary fat in healthy young adults. Volunteers (n = 43) with the apoE3/E3 genotype (8 GG, 25 GT and 10 TT) completed 3 dietary ...

Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins

2005 - Elsevier BV | Journal of Nutrition

Artigo Revisado por pares

Antonio García‐Ríos, Francisco Gómez-Delgado, Marta Garaulet, Juan F. Alcalá‐Díaz, Javier Delgado‐Lista, Carmen Marı́n, Oriol Alberto Rangel-Zúñiga, Fernando Rodríguez-Cantalejo, Purificación Gómez-Luna, José M. Ordovás, Francisco Pérez‐Jiménez, José López‐Miranda, Pablo Pérez‐Martínez,

Genetic variation at the Circadian Locomotor Output Cycles Kaput (CLOCK) locus has been associated with lifestyle-related conditions such as obesity, metabolic syndrome (MetS) and cardiovascular diseases. In fact, it has been suggested that the disruption of the circadian system may play a causal role in manifestations of MetS. The aim of this research was to find out whether habitual consumption of a low-fat diet, compared with a Mediterranean diet enriched with olive oil, modulates the associations ...

Tópico(s): Diet, Metabolism, and Disease

2013 - Taylor & Francis | Chronobiology International

Artigo Revisado por pares

Olivia García‐Suárez, M.G. Calavia, Francisco J. Pérez-Moltó, Covadonga Álvarez‐Abad, Pablo Pérez‐Piñera, Juan Manuel Dieste Cobo, José A. Vega,

To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery.We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial ...

Tópico(s): Lipid Membrane Structure and Behavior

2010 - Lippincott Williams & Wilkins | Pancreas

Revisão Acesso aberto Revisado por pares

Francisco Pérez‐Jiménez, Javier Delgado‐Lista, Pablo Pérez‐Martínez, Fernando Lopez‐Segura, Francisco Fuentes, Begoña Cortés Rodríguez, A. Lozano, José López‐Miranda,

Abstract Interest in the Mediterranean diet (MD) has grown worldwide. Despite the high complexity of its nutrients composition, olive oil emerges as its principal food, since it provides the higher percentage of energy and a lot of bioactive compounds. Objective In this review, we will discuss the benefits of diets enriched in virgin olive oil, whose effects are probably due not only to its oleic acid content but also to its other potentially health-promoting components. Methods Traditionally, the ...

Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases

2006 - Cambridge University Press | Public Health Nutrition

Artigo Revisado por pares

Francisco Gómez-Delgado, Juan F. Alcalá‐Díaz, Antonio García‐Ríos, Javier Delgado‐Lista, Ana M. Ortiz-Morales, Oriol Alberto Rangel-Zúñiga, Francisco J. Tinahones, Lorena González-Guardia, Marı́a M. Malagón, Enrique Bellido‐Muñoz, José M. Ordovás, Francisco Pérez‐Jiménez, José López‐Miranda, Pablo Pérez‐Martínez,

Scope To examine whether the consumption of a M editerranean diet ( M ed D iet), compared with a low‐fat diet, interacts with two single nucleotide polymorphisms at the tumor necrosis factor alpha gene (rs1800629, rs1799964) in order to improve triglycerides ( TG ), glycemic control, and inflammation markers. Methods and results Genotyping, biochemical measurements, dietary intervention, and oral fat load test meal were determined in 507 metabolic syndrome ( M et S ) patients selected from all the subjects ...

Tópico(s): Adipose Tissue and Metabolism

2014 - Wiley | Molecular Nutrition & Food Research