Giuseppe Faita, Mariella Mella, Annalisa Mortoni, Alfredo Paio, Paolo Quadrelli, Pierfausto Seneci,
... Pavia, ItalySearch for more papers by this authorAlfredo Paio, Alfredo Paio GlaxoSmithKline Group, Glaxo Wellcome Medicines Research Centre, Via ... Pavia, ItalySearch for more papers by this authorAlfredo Paio, Alfredo Paio GlaxoSmithKline Group, Glaxo Wellcome Medicines Research Centre, Via ...
Tópico(s): Multicomponent Synthesis of Heterocycles
2002 - Wiley | European Journal of Organic Chemistry
Tuanfei Zhu, Yaping Lin, Yonghe Liu,
... flaws, a Position characteristic-Aware Interpolation Oversampling algorithm (PAIO) is proposed. PAIO first leverages a neighborhood-based clustering algorithm to ... datasets demonstrate that the effectiveness of the proposed PAIO and GIC.
Tópico(s): Artificial Intelligence in Healthcare
2019 - Elsevier BV | Knowledge-Based Systems
Produção Nacional
Revisado por pares
Camila Vespúcio Bis SOUZA, Elisa Rafaela Bonádio Bellucci, José M. Lorenzo, Andrea Carla da Silva Barretto,
... fiber and inulin as fat substitutes in cooked Paio sausage using response surface methodology. The chemical composition, ... 85% oat fiber in a low fat cooked Paio sausage did not compromise technological parameters and sensory ...
Tópico(s): Animal Nutrition and Physiology
2019 - Sociedade Brasileira de Ciência e Tecnologia de Alimentos | Food Science and Technology
Agustín Ibáñez, Georg Northoff,
... the predictive coding theory of allostatic interoceptive overload (PAIO) and the intrinsic neural timescales (INT) theory to ... understanding of brain health in psychiatry and neurology. PAIO integrates allostasis and interoception to assess the interaction ...
Tópico(s): Health, Environment, Cognitive Aging
2023 - Elsevier BV | Neuroscience & Biobehavioral Reviews
Miguel Elías, Maria Eduarda Potes, L.C. Roseiro, C. Santos, A. Gomes, Ana Cristina Agulheiro‐Santos,
<p>“Paio do Alentejo” is a Portuguese dry-cured sausage, made with meat from the Alentejano pig breed. The ...
Tópico(s): Fermentation and Sensory Analysis
2014 - Canadian Center of Science and Education | Journal of Food Research
Miguel Elías, Alfonso V. Carrascosa,
... Alentejo Portuguese region to study the characterization of "Paio do Alentejo", a traditional Iberian dry-cured sausage. ...
Tópico(s): Animal Nutrition and Physiology
2009 - Elsevier BV | Food Control
... diferentes epocas de ano, de um tipo de paio de porco da raca Alentejana. Numa das fabricas ... a humidade relativa, entre lotes de producao de paio de porco da raca Alentejana. Este facto, seguramente ...
Tópico(s): Meat and Animal Product Quality
2007 - Sociedade de Ciências Agrárias de Portugal | Revista de Ciências Agrárias
Shapour Azarm, Zissimos P. Mourelatos,
... the PATC against a probabilistic all-in-one (PAIO) approach and shows that within the limits of ... PATC converges to the same optimal solution as PAIO does.The paper by Gu, Renaud, and Penninger ...
Tópico(s): Topology Optimization in Engineering
2006 - American Society of Mechanical Engineers | Journal of Mechanical Design
Nina Dirkx, Wout J. Weuring, Els De Vriendt, Noor Smal, J. van de Vondervoort, Ruben van ‘t Slot, M.P. Koetsier, N. Zonnekein, Tim De Pooter, Sarah Weckhuysen, Bobby P.C. Koeleman,
... and PE4max by generating novel all-in-one (pAIO) plasmids driven by an EF-1α promoter, which ... human-induced pluripotent stem cell (hiPSC) models. Results pAIO-EF1α-PE2 and pAIO-EF1α-PE4max were used to edit the voltage ... SCN1A. Two clinically relevant mutations were corrected using pAIO-EF1α-PE2 including the homozygous truncating SCN1A R612* ... were no genome-wide off-target effects using pAIO-EF1α-PE2 and no off-target editing activity ... an improved efficacy of EF-1α driven sncRNA pAIO-PE plasmids in hiPSC reaching high editing rates, ...
Tópico(s): Virus-based gene therapy research
2023 - BioMed Central | BMC Biology
Igor Dias, Marta Laranjo, Maria Eduarda Potes, Ana Cristina Agulheiro‐Santos, Sara Ricardo‐Rodrigues, Maria João Fraqueza, Margarida Oliveira, Miguel Elías,
Paio do Alentejo (PA) is one of the most popular dry-fermented sausages in Portugal. The aim ...
Tópico(s): Meat and Animal Product Quality
2022 - Multidisciplinary Digital Publishing Institute | Fermentation
Igor Dias, Marta Laranjo, Maria Eduarda Potes, Ana Cristina Agulheiro‐Santos, Sara Ricardo‐Rodrigues, Ana Rita Fialho, Joana Véstia, Maria João Fraqueza, Margarida Oliveira, Miguel Elías,
... cured sausages are traditional in Mediterranean countries, and Paio do Alentejo (PA) is one of the most ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Sara Correia Santos, Maria João Fraqueza, Miguel Elías, A.S. Barreto, Teresa Semedo‐Lemsaddek,
... sausages produced in Portugal (Catalão, Chouriço-Preto, Linguiça, Paio and Salsichão). Fingerprinting analysis revealed high similarity levels ...
Tópico(s): Food Safety and Hygiene
2017 - Elsevier BV | LWT
Inayatullah Jan, Sabir Ullah, Waqar Akram, Noor Paio Khan, Syed Muhammad Asim, Zafar Mahmood, Muhammad Nauman Ahmad, Shaikh S. Ahmad,
About three billion people worldwide use solid fuels for cooking and space heating. This fueling practice contributes to global forest depletion and disease prevalence. To abate the environmental and health threats caused by the inefficient burning of biomass fuels, large-scale initiatives were undertaken globally for the dissemination of fuel-saving and energy-efficient stoves, known as improved cookstoves (ICS). This paper examines the adoption of ICS in northwest Pakistan by using a logit analysis. ...
Tópico(s): Electric Vehicles and Infrastructure
2017 - Elsevier BV | Biomass and Bioenergy
Sk Jahiruddin, Nilangshu Mandal, Ayan Datta,
... optimized to be a better fit inside a pAIO plasmid. Based on both implicit and explicit dispersion- ...
Tópico(s): RNA and protein synthesis mechanisms
2017 - Wiley | ChemPhysChem
Bruno Nunes, Dolors Vidal Casellas, Inês A. Barbosa, Amadeu M.V.M. Soares, Rosa Freitas,
... Aveiro (Laranjo and São Jacinto), Douro River (São Paio, Afurada, and Ribeira da Granja), both impacted by ...
Tópico(s): Pesticide Exposure and Toxicity
2016 - Royal Society of Chemistry | Environmental Science Processes & Impacts
Pavan S. Kulkarni, Daniele Bortoli, Ana Domingue, Ana Maria Silva,
... in Jan 2002 (17 µg m–3) at Paio Pires. The trend analysis of (1) original surface ...
Tópico(s): Air Quality and Health Impacts
2015 - Taiwan Association for Aerosol Research | Aerosol and Air Quality Research
Dražen Pavlović, Stjepan Mutak, Daniele Andreotti, Stefano Biondi, Francesca Cardullo, Alfredo Paio, Elisa Piga, Daniele Donati, Sergio Lociuro,
An efficient synthesis of α-amino-γ-lactone ketolide (3) was developed, which provided a versatile intermediate for the incorporation of a variety of aryl and heteroaryl groups onto the C-21 position of clarithromycin via HBTU-mediated amidation. The biological data for this important new class of macrolides revealed significantly potent activity against erythromycin-susceptible strains as well as efflux-resistant and erythromycin MLSB-resistant strains of S. pneumoniae and S. pyogenes. In addition, ...
Tópico(s): Synthesis and Catalytic Reactions
2014 - American Chemical Society | ACS Medicinal Chemistry Letters
Miguel Elías, Alfonso V. Carrascosa,
Tópico(s): Animal Nutrition and Physiology
2013 - Deutscher Fachverlag | Fleischwirtschaft international
Ching-Paio Tsai, Bing‐Wen Soong, Pang‐Hsien Tu, Kon‐Ping Lin, Jong‐Ling Fuh, Pei‐Chien Tsai, Yi‐Chun Lu, I‐Hui Lee, Yi‐Chung Lee,
A GGGGCC hexanucleotide repeat expansion in the C9ORF72 gene was recently identified as an important cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia in Caucasian populations. The role of the C9ORF72 repeat expansion in ALS in Chinese populations has received little attention. We therefore performed mutation analyses in a Taiwanese cohort of 22 unrelated familial ALS (FALS) patients and 102 sporadic ALS patients of Han Chinese descent. The C9ORF72 mutation was found ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2012 - Elsevier BV | Neurobiology of Aging
Alexandra Paio, Sara Eloy, Vasco Rato, Ricardo Resende, Maria João de Oliveira,
Tópico(s): Innovations in Concrete and Construction Materials
2012 - Birkhäuser | Nexus Network Journal
Paola Zarantonello, Ezio Bettini, Alfredo Paio, Chiara Simoncelli, Silvia Terreni, Francesco Cardullo,
The identification of structurally novel analogues of ketamine and phencyclidine (PCP), as NMDA receptor antagonists, with low to moderate potency at GluN2A and GluN2B receptors is discussed. In particular, some examples, such as compounds 6 and 10, shows decreased calculated lipophilicity, when compared to PCP, while retaining moderate activity. Moreover, the germinal aryl amino substituted lactam ring, as exemplified in compounds 7–10 and 11–13, constitutes a novel scaffold with potential application ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2011 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Ching-Paio Tsai, Bing‐Wen Soong, Kon‐Ping Lin, Pang‐Hsien Tu, Jer-Li Lin, Yi‐Chung Lee,
The cause of familial amyotrophic lateral sclerosis (FALS) has been attributed to mutations in several genes. The authors analyzed these genes, including SOD1, FUS, VAPB, ANG, TDP-43, FIG4, and CHMP2B, in a cohort of 15 index patients of Han Chinese descent with adult-onset FALS. Seven different mutations in eight patients, including three in SOD1 (G85R, T137R, and G138E), two in exon 15 of FUS (H517D and R521H), and two in exon 6 of TARDBP (M337V and N378D) were identified. Among them, T137R SOD1, ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2010 - Elsevier BV | Neurobiology of Aging
Produção Nacional
... e 1774, comandadas por Afonso Botelho de San Paio e Sousa a mando D. Luís Antônio de ...
Tópico(s): History of Education Research in Brazil
2008 - UNIVERSIDADE FEDERAL DE MINAS GERAIS | Varia Historia
Fabrizio Micheli, Barbara Bertani, Andrea Bozzoli, Luca Crippa, Paolo Cavanni, Romano Di Fabio, Daniele Donati, Paola Marzorati, Giancarlo Merlo, Alfredo Paio, Lorenzo Perugini, Paola Zarantonello,
Tópico(s): Synthesis and Biological Evaluation
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Francesca Cardullo, Daniele Donati, Vincenzo Fusillo, Giancarlo Merlo, Alfredo Paio, Margherita Salaris, Antonio Solinas, Maurizio Taddei,
One of the still unresolved problems in parallel synthesis is the availability of a general and rapid method for the transformation of a primary amine into the corresponding secondary amine without the issue of polyalkylation. Following the Fukuyama method, which is based on the alkylation of o-nitrobenzenesulfonamides, followed by removal of the sulfonyl group, we have developed a simple protocol which can be easily applied to parallel synthesis making use of supported reagents and scavengers. ...
Tópico(s): Catalytic Cross-Coupling Reactions
2006 - American Chemical Society | Journal of Combinatorial Chemistry
Fabrizio Micheli, Romano Di Fabio, Paolo Cavanni, Joseph M. Rimland, Anna Maria Capelli, Cristiano Chiamulera, Mauro Corsi, Corrado Corti, Daniele Donati, Aldo Feriani, Francesco Ferraguti, Micaela Maffeis, Andrea Missio, Emiliangelo Ratti, Alfredo Paio, Roberta Pachera, M. Quartaroli, Angelo Reggiani, Fabio Maria Sabbatini, David G. Trist, Annarosa Ugolini, Giovanni Vitulli,
Tópico(s): Photochromic and Fluorescence Chemistry
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry
... quali provengono potrebbero essere stati costruiti precedentemente. Un paio di frammenti di mulini in pietra di età ...
Tópico(s): Conservation Techniques and Studies
2003 - Cambridge University Press | Papers of the British School at Rome
Carlos Fernández‐Tornero, Rosa M. Lozano, Mariano Redondo‐Horcajo, Ana M. Gómez, J. Cristóbal López, Ernesto Quesada, Clara Uriel, Serafı́n Valverde, Pedro Cuevas, Antonio Romero, Guillermo Giménez‐Gallego,
... induced angiogenesis and neovascularization in vivo (29Mariani M. Paio A. Ciomei M. Pastori W. Franzetti C. Melegaro ...
Tópico(s): Fibroblast Growth Factor Research
2003 - Elsevier BV | Journal of Biological Chemistry
Elena La Porta, Umberto Piarulli, Francesca Cardullo, Alfredo Paio, Stefano Provera, Pierfausto Seneci, Cesare Gennari,
A new synthesis of macrolactones bearing a cyclopropyl ring condensed to the macrocycle is reported via a cyclization-release strategy making use of solid-phase supported stabilized sulfur ylides.
Tópico(s): Advanced Synthetic Organic Chemistry
2002 - Elsevier BV | Tetrahedron Letters
Esther Fernández, Silvestre Garcı́a-Ochoa, S. HUSS, Araceli Mallo, José M. Bueno, Fabrizio Micheli, Alfredo Paio, Elisabetta Piga, Paola Zarantonello,
Herein we describe a straightforward solid-phase synthesis directed towards the preparation of families of asymmetrically disubstituted furazano[3,4-b]pyrazines by stepwise displacement of the two chlorine atoms in 5,6-dichlorofurazano[3,4-b]pyrazine by nucleophiles. This synthesis has avoided selectivity problems found in solution chemistry.
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2002 - Elsevier BV | Tetrahedron Letters