... 7]. In the previous issue of PLOS Genetics, Palian et al. describe new insights into the regulation ... and humans) [2], [3]. The new work from Palian and colleagues shows that the steady-state level ... deficient human glioblastoma cells [20]. Expanding on this, Palian et al., report that Maf1 levels are reduced ... expression of gluconeogenic genes [21]. The work from Palian et al., provides new knowledge in this regard, ...
Tópico(s): Fungal and yeast genetics research
2015 - Public Library of Science | PLoS Genetics
Michael M. Palian, Robin Polt,
... Building Blocks for Ceramyl and Glycosphingoyl PeptidesMichael M. Palian and Robin PoltView Author Information Department of Chemistry, ...
Tópico(s): Synthesis and Catalytic Reactions
2001 - American Chemical Society | The Journal of Organic Chemistry
Jaskaran Singh Saini, Collin Palian, Fuqiong Lei, Alexander Dyall, Nick AuYeung, Ryan McQuade, Sanu K. Gupta, David P. Cann, Donghua Xu,
Metallic glasses have many fascinating properties such as theoretical-limit approaching strength, high wear and corrosion resistance, and extremely smooth surfaces enabling high-performance thin film diodes. Copper-based metallic glasses are of particular interest due to the low cost and attractive characteristics of the base element, but the copper-based metallic glasses known to date rely on rare-earth or precious metals that have limited supplies and relatively high cost, in order to achieve ...
Tópico(s): Glass properties and applications
2020 - American Institute of Physics | Applied Physics Letters
Igor Motuzyuk, Oleg Sydorchuk, Natalia Kovtun, Z. Palian, Yevhenii Kostiuchenko,
The study aims to evaluate the current state and tendencies in multiple primary breast cancer incidence, behavior, and treatment in Ukraine.A total of 2032 patients who received special treatment at the Department of Breast Tumors and Reconstructive Surgery of the National Cancer Institute from 2008 to 2015 were included in the study. Among them, there were 195 patients with multiple primary malignant neoplasms: 54.9% patients with synchronous cancer and 45.1% patients with metachronous cancer. ...
Tópico(s): Cancer Risks and Factors
2018 - SAGE Publishing | Breast Cancer Basic and Clinical Research
Beth M. Palian, Aarti D. Rohira, Sandra Johnson, Lina He, Ni Zheng, Louis Dubeau, Bangyan L. Stiles, Deborah L. Johnson,
Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes, yet little is known about its other potential target genes or its biological function. Here, we show that Maf1 is a key downstream target of PTEN that drives both its tumor suppressor and metabolic functions. Maf1 expression is diminished with loss of PTEN in both mouse models and human cancers. Consistent with its role as a tumor suppressor, Maf1 reduces anchorage-independent growth and tumor formation ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2014 - Public Library of Science | PLoS Genetics
Ni Zeng, Kaiting Yang, Jennifer‐Ann Bayan, Lina He, Richa Aggarwal, Joseph W. Stiles, Xiaogang Hou, Vivian Medina, Danny Abad, Beth M. Palian, Ismail H. Al-Abdullah, Fouad Kandeel, Deborah L. Johnson, Bangyan L. Stiles,
Tissue regeneration diminishes with age, concurrent with declining hormone levels including growth factors such as insulin-like growth factor-1 (IGF-1). We investigated the molecular basis for such decline in pancreatic β-cells where loss of proliferation occurs early in age and is proposed to contribute to the pathogenesis of diabetes. We studied the regeneration capacity of β-cells in mouse model where PI3K/AKT pathway downstream of insulin/IGF-1 signaling is upregulated by genetic deletion of ...
Tópico(s): Diet, Metabolism, and Disease
2013 - Wiley | Aging Cell
Erik Horstman, Marjolein Dohmen‐Janssen, Pedro Narra, Niels-Jasper van den Berg, Martijn Siemerink, Thorsten Balke, Tjeerd J. Bouma, Suzanne J.M.H. Hulscher,
... over a distance of 246 m. Along the Palian transect, mostly exposed to sea waves instead, vegetation ...
Tópico(s): Aeolian processes and effects
2012 - Coastal Engineering Research Council | Coastal Engineering Proceedings
Mark Trottier, Beth M. Palian, Carol Shoshkes Reiss,
Vesicular stomatitis virus (VSV) is a rhabdovirus which causes acute encephalitis in mice after intranasal infection. Because type I interferon (IFN) has been shown to be a potent inhibitor of VSV, we investigated the role of type I IFN in viral replication in neurons in culture. Pre-treatment of NB41A3 neuroblastoma cells or primary neuron cultures with IFN-β or IFN-α strongly inhibits virus replication, with 1000-fold inhibition of infectious virus release occurring at 7 h post-infection, and maximum ...
Tópico(s): Animal Virus Infections Studies
2005 - Elsevier BV | Virology
M. Dhanasekaran, Michael M. Palian, Isabel D. Alves, Larisa Yeomans, Charles M. Keyari, Peg Davis, Edward J. Bilsky, Richard D. Egleton, Henry I. Yamamura, Neil E. Jacobsen, Gordon Tollin, Victor J. Hruby, Frank Porreca, Robin Polt,
A series of glycosylated endorphin analogues designed to penetrate the blood−brain barrier (BBB) have been studied by circular dichroism and by 2D-NMR in the presence of water; TFE/water; SDS micelles; and in the presence of both neutral and anionic bicelles. In water, the glycopeptides showed only nascent helix behavior and random coil conformations. Chemical shift indices and nuclear Overhauser effects (NOE) confirmed helices in the presence of membrane mimics. NOE volumes provided distance constraints ...
Tópico(s): Cellular transport and secretion
2005 - American Chemical Society | Journal of the American Chemical Society
S. M. Rajendran, S. C. Agarwal, Venkatesan Sundaresan,
... search for plants used as ethnomedicinals by the Palian tribe of Ayyanarkoil hill range of Virkudunagar forest ...
Tópico(s): Botanical Research and Chemistry
2004 - Taylor & Francis | Journal of Herbs Spices & Medicinal Plants
Nura O. Elmagbari, Richard D. Egleton, Michael M. Palian, John J. Lowery, W Schmid, Peg Davis, Edita Navratilova, M. Dhanasekaran, Charles M. Keyari, Henry I. Yamamura, Frank Porreca, Victor J. Hruby, Robin Polt, Edward J. Bilsky,
Development of opioid peptides as therapeutic agents has historically been limited due to pharmacokinetic issues including stability and blood-brain barrier (BBB) permeability. Glycosylation of opioid peptides can increase peptide serum stability and BBB penetration. To further define the requirements for optimizing in vivo antinociceptive potency following intravenous administration, we synthesized a series of enkephalin-based glycopeptides using solid phase 9-fluorenylmethyloxy carbamate methods. ...
Tópico(s): Glycosylation and Glycoproteins Research
2004 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Michael M. Palian, V. I. Boguslavsky, David F. O'Brie, Robin Polt,
Four enkephalin analogues (Tyr-D-Thr-Gly-Phe-Leu-Ser-CONH2, 1, and the related O-linked glycopeptides bearing the monosaccharide β-glucose, 2, the disaccharide β-maltose, 3, and the trisaccharide β-maltotriose, 4) were synthesized, purified by HPLC, and biophysical studies were conducted to examine their interactions with membrane model systems. Glycopeptide 2 has been previously reported to penetrate the blood-brain barrier (BBB), and produce potent analgesia superior to morphine in mice (J. Med. ...
Tópico(s): Lipid Membrane Structure and Behavior
2003 - American Chemical Society | Journal of the American Chemical Society
Richard D. Egleton, Scott A. Mitchell, Jason D. Huber, Michael M. Palian, Robin Polt, Thomas P. Davis,
Neuropeptide pharmaceuticals have potential for the treatment of neurological disorders, but the blood-brain barrier (BBB) limits entry of peptides to the brain. Several strategies to improve brain delivery are currently under investigation, including glycosylation. In this study we investigated the effect of O-linked glycosylation on Ser(6) of a linear opioid peptide amide Tyr-D-Thr-Gly-Phe-Leu-Ser-NH(2) on metabolic stability, BBB transport, and analgesia. Peptide stability was studied in brain ...
Tópico(s): Receptor Mechanisms and Signaling
2001 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Robin Polt, Michael M. Palian,
Tópico(s): Glycosylation and Glycoproteins Research
2001 - Thomson Reuters | Drugs of the Future
Edward J. Bilsky, Richard D. Egleton, Scott A. Mitchell, Michael M. Palian, Peg Davis, Jason D. Huber, Heather Jones, Henry I. Yamamura, Jacqueline Janders, Thomas P. Davis, Frank Porreca, Victor J. Hruby, Robin Polt,
Endogenous peptides (e.g. enkephalins) control many aspects of brain function, cognition, and perception. The use of these neuroactive peptides in diverse studies has led to an increased understanding of brain function. Unfortunately, the use of brain-derived peptides as pharmaceutical agents to alter brain chemistry in vivo has lagged because peptides do not readily penetrate the blood−brain barrier. Attachment of simple sugars to enkephalins increases their penetration of the blood−brain barrier ...
Tópico(s): Chemical Synthesis and Analysis
2000 - American Chemical Society | Journal of Medicinal Chemistry
Noppadon Podkumnerd, Supranee Wunsri, Sujint Khairin,
... The SDC and SDCH techniques were implemented at Palian river basin community (Ban Na Yod Tong Nipa ...
Tópico(s): Oil Palm Production and Sustainability
2019 - | Malaysian Journal of Fundamental and Applied Sciences
Phaibul Naiyanetr, Peter K. L. Ng,
... described from southern Thailand. The new species, T. palian, can be distinguished from T. abbotti (Rathbun, 1898) ...
Tópico(s): Coral and Marine Ecosystems Studies
1998 - Brill | Crustaceana
... generated by the manufacturing process of bricks in Palian and San Agustin de Cajas in Huancayo city. ... people (as) questionnaire was applied boxes and Annex Palian in the province of Huancayo. Results: Respondents indicate ... of San Agustin de Cajas and the annex Palian generates social and environmental impacts.
Tópico(s): Environmental and Cultural Studies in Latin America and Beyond
2013 - Universidad Continental | Apuntes de Ciencia & Sociedad
Derek D.C. Ireland, Beth M. Palian, Carol Shoshkes Reiss,
Vesicular stomatitis virus (VSV), a negative-sense, single-stranded RNA rhabdovirus, causes acute viral encephalitis when administered intranasally to mice. Interleukin-12 (IL-12) is a key pro-inflammatory cytokine that is produced largely by the antigen presenting cells (APC) and that bridges the innate and acquired immune responses. IL-12 is efficacious in enhancing recovery from VSV infection of the murine central nervous system. This effect is mediated by nitric oxide (NO) produced by the neuronal ...
Tópico(s): Poxvirus research and outbreaks
2005 - Mary Ann Liebert, Inc. | Viral Immunology
Michael M. Palian, Neil E. Jacobsen, Robin Polt,
Abstract: A 17‐residue O‐linked glycopeptide model incorporating a central α‐mannosyl serine residue, and its unglycosylated analog both demonstrate substantial helicity in water. The peptide sequence was derived from previous studies in which differences in overall helicity as a function of single amino acid substitutions were measured by circular dichroism (CD). The helical content was predicted by molecular modeling, and confirmed by CD and NMR. Moreover, the glycopeptide retained its helicity ...
Tópico(s): Chemical Synthesis and Analysis
2001 - Wiley | Journal of Peptide Research
Steven M. Florence, Craig C. Willard, Charles W. Palian,
Hemangiopericytoma is an uncommon mesenchymal tumor that represents 1% of all vascular neoplasms. 1 Batsakis JG Jacobs JB Templeton AC Hemangiopericytoma of the nasal cavity: Electron-optic study and clinical correlations. J Laryngol Otol. 1983; 97: 361 Crossref PubMed Scopus (49) Google Scholar In a study by Enzinger and Smith, 2 Enzinger FM Smith BH Hemangiopericytoma: An analysis of 106 cases. Human Pathol. 1976; 7: 61 Abstract Full Text PDF PubMed Scopus (755) Google Scholar 16% of these tumors ...
Tópico(s): Oral and Maxillofacial Pathology
2001 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Ivona Hanžek, Dinko Tonković, Nataša Margaretić Piljek, Magdalena Palian, Dragan Mihaljević, Ante Penavić, Slobodan Mihaljević,
Allergic reactions in anesthesia are a rare event, however, might be life threatening when occurred. Clinical manifestations may not be indicative at first, and difficult to differentiate from different situations during operation and anesthesia. Colloids represent a group of fluids often used during perioperative period that, among other adverse reactions, have an allergic potential. Albumin is a natural colloid that has the lowest incidence of these reactions. However, it is found as an additional ...
Tópico(s): Biomedical and Chemical Research
2020 - Medicinska naklada, Zagreb | Psychiatria Danubina
... teaching these construction techniques to the communities of Palian and Cochas that they belong to the territory ...
Tópico(s): Architecture and Computational Design
2023 - Springer International Publishing | Sustainable development goals series
Noppadon Podkumnerd, Kosin Teeparuksapun, Supranee Wunsri, Nicha Prasongchan, Vakin Nunumvong, Soemsak Sunyano,
... Nipa bowls which are local products of the Palian river basin community, Trang province in Southern Thailand, ... of more than 84,000 USD to the Palian river basin community.
Tópico(s): Coconut Research and Applications
2022 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural
Tueanta Ramarn, Tanya Panritdam,
... predator and prey.However, study of hyperbenthos in Palian mangrove estuary was scare.The aims of present ... the diversity and abundance of hyperbenthos in the Palian mangrove estuary, to investigate the feeding ecology of Silago sihama and Toxotes chatareus in the Palian mangrove estuary, and to elucidate the trophic role ... fish, S. sihama and T. chatareus, in the Palian mangrove estuary.Methodology and results: Hyperbenthos and fishes ... study: It can be concluded that hyperbenthos in Palian mangrove estuary are in high diversity and they ...
Tópico(s): Parasite Biology and Host Interactions
2018 - Malaysian Society for Microbiology | Malaysian Journal of Microbiology
R. Nuñez-Calonge, S. Cortés, Marta Gago, Palián López, P. Caballero-Peregrín,
Objective. To optimise the use of freeze/thaw testicular immotile spermatozoa from nonobstructive azoospermia patients and to analyse the outcome of intracytoplasmic sperm injection (ICSI) of such spermatozoa. Methods. Testicular specimens were retrieved and cryopreserved from forty patients with nonobstructive azoospermia and underwent one cycle with thawed spermatozoa (Group I) that led to pregnancy in sixteen cases. Twenty-four patients of group I underwent treatment with the same batch of thawed ...
Tópico(s): Male Reproductive Health Studies
2012 - Hindawi Publishing Corporation | ISRN Urology
Glen A. Smith, Charles W. Palian,
An account is given of the forensic dental aspects of the investigation of a military air disaster. Ten of fourteen victims had dental structures remaining for postmortem evaluation. Of those ten, all were successfully identified by dental means. A six man dental team took three days to complete the evaluation. Specific problems encountered are reported, and recommendations to overcome these problems and simplify the processing of military dental IDs are submitted.
Tópico(s): Autopsy Techniques and Outcomes
1985 - Oxford University Press | Military Medicine
P Ravi Shankar, Palian Subish,
... Lalitpur, NepalSearch for more papers by this authorDr Palian Subish MPharm, PhD, Dr Palian Subish MPharm, PhD Associate Professor Department of Pharmacology, ... Lalitpur, NepalSearch for more papers by this authorDr Palian Subish MPharm, PhD, Dr Palian Subish MPharm, PhD Associate Professor Department of Pharmacology, ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2011 - Wiley | Journal of Pharmacy Practice and Research
Kelly B. Cartwright, Sierra R. Palian,
Tópico(s): Cognitive and developmental aspects of mathematical skills
2024 - Routledge | Educational Psychologist
... procedentes de la flora silvestre del Anexo de Palián (Huancayo) y se trabajó con cinco extractos obtenidos ...
Tópico(s): Bee Products Chemical Analysis
2024 - Latin American Association for the Advancement of Sciences | Ciencia Latina Revista Científica Multidisciplinar