Produção Nacional
Revisado por pares
Estevão Carlos Silva Barcelos, Chiara Rompietti, Francesco Maria Adamo, Erica Dorillo, Filomena De Falco, Beatrice Del Papa, Stefano Baldoni, Manuel Nogarotto, Angela Espósito, Silvia Capoccia, Clelia Geraci, Daniele Sorcini, Arianna Stella, Roberta Arcaleni, Valentina Tini, Flávia Imbroisi Valle Errera, Emanuela Rosati, Paolo Sportoletti,
Constitutive activation of NOTCH1-wild-type (NT1-WT) signaling is associated with poor outcomes in chronic lymphocytic leukemia (CLL), and NOTCH1 mutation (c.7541_7542delCT), which potentiates NOTCH1 signaling, worsens the prognosis. However, the specific mechanisms of NOTCH1 deregulation are still poorly understood. Accumulative evidence mentioned endoplasmic reticulum (ER) stress/unfolded protein response (UPR) as a key targetable pathway in CLL. In this study, we investigated the impact of NOTCH1 ...
Tópico(s): Ubiquitin and proteasome pathways
2023 - Frontiers Media | Frontiers in Oncology