Davide Caruso, Anselmo Papa, Silverio Tomao, Patrizia Vici, Pierluigi Benedetti Panici, Federica Tomao,
Ovarian cancer is the first cause of death from gynaecological malignancy. Germline mutation in BRCA1 and 2, two genes involved in the mechanisms of reparation of DNA damage, are showed to be related with the incidence of breast and ovarian cancer, both sporadic and familiar. PARP is a family of enzymes involved in the base excision repair (BER) system. The introduction of inhibitors of PARP in patients with BRCA-mutated ovarian cancer is correlated with the concept of synthetic lethality. Among ...
Tópico(s): CRISPR and Genetic Engineering
2017 - SAGE Publishing | Therapeutic Advances in Medical Oncology
Serena Del Turco, Stefania Sartini, Giulia Cigni, Cassandra Sentieri, Silverio Sbrana, Debora Battaglia, Angela Papa, Federico Da Settimo, Concettina La Motta, Giuseppina Basta,
We investigated the ability of quercetin and apigenin to modulate platelet activation and aggregation, and compared the observed efficacy with that displayed by their synthetic analogues 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-ones, 1–4, and 2,3-diphenyl-4H-pyrido[1,2-a]pyrimidin-4-ones, 5–7. Platelet aggregation was explored through a spectrophotometric assay on platelet-rich plasma (PRP) treated with the thromboxane A2 mimetic U46619, collagen and thrombin in presence/absence of various bioisosteres ...
Tópico(s): Ginseng Biological Effects and Applications
2014 - Elsevier BV | Food Chemistry
Andrea Boari, Vincenzo Papa, F. Di Silverio, Giovanni Aste, Daymela Pupo Olivero, Francesca Rocconi,
Diabetes mellitus (DM) was diagnosed in a 6-year-old neutered male ferret with polyuria/polydipsia, symmetrical alopecia, and weight loss. Laboratory tests revealed severe hyperglycemia, glucosuria, and increased steroid hormone profile. Abdominal ultrasound revealed a bilateral enlargement of the adrenal glands. Significant clinical improvement was achieved with insulin- and leuprolide acetate-based therapy. After 2 months of therapy, the ferret showed a severe ketoacidosis, and the owner decided ...
Tópico(s): Diabetes and associated disorders
2010 - Springer Science+Business Media | Veterinary Research Communications
Federica Tomao, Giuseppe Lo Russo, Gian Paolo Spinelli, Valeria Stati, Alessandra Anna Prete, Natalie Prinzi, Marsela Sinjari, Patrizia Vici, Anselmo Papa, Maria Chiotti, Pierluigi Benedetti Panici, Silverio Tomao,
Several adverse effects have been related to infertility treatments, such as cancer development. In particular, the relationship between infertility, reproductive strategies, and risk of gynecological cancers has aroused much interest in recent years. The evaluation of cancer risk among women treated for infertility is very complex, mainly because of many factors that can contribute to occurrence of cancer in these patients (including parity status). This article addresses the possible association ...
Tópico(s): Ovarian function and disorders
2014 - BioMed Central | Journal of Ovarian Research
Federica Tomao, Anselmo Papa, Luigi Rossi, Martina Strudel, Patrizia Vici, Giuseppe Lo Russo, Silverio Tomao,
Abstract In 2013 there will be an estimated 22,240 new diagnoses and 14,030 deaths from ovarian cancer in the United States. Despite the improved surgical approach and the novel active drugs that are available today in clinical practice, about 80% of women presenting with late-stage disease have a 5-year survival rate of only 30%. In the last years a growing scientific knowledge about the molecular pathways involved in ovarian carcinogenesis has led to the discovery and evaluation of several novel ...
Tópico(s): Ovarian cancer diagnosis and treatment
2013 - BioMed Central | Journal of Experimental & Clinical Cancer Research
M Tribalto, Sergio Amadori, Maria Cantonetti, A. Franchi, Giuseppe Francesco Sferrazza Papa, Alessandro Pileri, Mario Boccadoro, F Dammacco, Angelo Vacca, Riccardo Centurioni, Pietro Leoni, Maria Paola Martelli, Franco Aversa, Maurizio Tonato, Luigi Deriu, Silverio Guarino, Alberto Neri, Filippo Pericoli Ridolfini, Franco Mandelli,
Tópico(s): Ubiquitin and proteasome pathways
1985 - Elsevier BV | Leukemia Research
Giordani Erika, Zoratto Federica, S. Martina, Papa Anselmo, Rossi Luigi, Minozzi Marina, Davide Caruso, Zaccarelli Eleonora, Verrico Monica, Tomao Silverio,
Gastrointestinal cancer treatment is based more on molecular biology that has provided increasing knowledge about cancer pathogenesis on which targeted therapy is being developed. Precisely, targeted therapy is defined as a "type of treatment that uses drugs, such as monoclonal antibodies or tyrosine kinase inhibitors, to identify and attack specific cancer cells". Nowadays, the United States Food and Drug Administration has approved many targeted therapies for gastrointestinal cancer treatment, ...
Tópico(s): Colorectal Cancer Treatments and Studies
2016 - Bentham Science Publishers | Current Cancer Drug Targets
Federica Tomao, Anselmo Papa, Giuseppe Lo Russo, Sara Zuber, Gian Paolo Spinelli, Luigi Rossi, Davide Caruso, Natalie Prinzi, Valeria Stati, Pierluigi Benedetti Panici, Silverio Tomao,
The relationship between fertility, reproductive hormones, and risk of malignant melanoma has acquired much interest in recent years. Melanocytes are hormonally responsive cells, and some in vitro studies demonstrated that estrogen hormones stimulate the growth of melanocytes. Moreover, estrogen receptors have been identified in melanoma cells, as well as in melanocytic nevi and in normal skin. Some evidences suggest a possible link between fertility treatments and the increased risk of malignant ...
Tópico(s): Ovarian function and disorders
2014 - SAGE Publishing | Tumor Biology
Luigi Rossi, Federica Zoratto, Angelo Zullo, Anselmo Papa, Eleonora Zaccarelli, Erika Giordani, G Baiano, Maria Antonietta Colonna, Luigi Tomao, Silverio Tomao Silverio,
Colorectal cancer is one of the most common cancers worldwide. The prognosis of patients with metastatic colorectal cancer in recent years has increased from 5 months with best supportive care to nearly 2 years with chemotherapy combined with bevacizumab, an antivascular endothelial growth factor monoclonal antibody. New prognostic and predictive biomarkers have been identified to guide chemotherapy in metastatic colorectal cancer, such as KRAS and BRAF oncogenes. However, the status of these oncogenes ...
Tópico(s): Cancer Treatment and Pharmacology
2012 - Dove Medical Press | OncoTargets and Therapy
Federica Tomao, Anselmo Papa, Silverio Tomao,
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry ...
Tópico(s): Birth, Development, and Health
2016 - American Medical Association | JAMA
Luigi Rossi, Anselmo Papa, Federica Tomao, Lucia Negri, Federica Tomao,
... other cancer characteristics. Citation Format: Luigi Rossi, Anselmo Papa, Federica Tomao, Lucia Negri, Silverio Tomao. Relationship of G-CSF related bone pain ( ...
Tópico(s): Thyroid Disorders and Treatments
2016 - American Association for Cancer Research | Cancer Research
Produção Nacional
Revisado por pares
Raphael Cavalcante Costa, B Nagay, Javier E.L. Villa, Marı́a Del Pilar Taboada Sotomayor, Lariel Chagas da Silva Neres, Bruna Benso, Sebastián Aguayo, Catarina M. Sacramento, Karina Gonzáles Silvério, Fernanda Papa Spada, Érica Dorigatti de Ávila, Monique Gonçalves da Costa, Leonardo Pérez Faverani, Luciano Tavares Ângelo Cintra, João Gabriel Silva Souza, Valentim Adelino Ricardo Barão,
Abstract Folate (FT) is a suitable targeting ligand for folate receptors (FOLR) overexpressed on inflamed cells. Thus, FT‐loaded polymers can be used as FOLRs‐targeted immunotherapy to positively modulate the inflammatory process. A novel biodegradable imprinted polymer with a FT delivery mechanism driven by pH changes [PCL‐MIP@FT] is designed with molecularly imprinted technology. The pH mechanism is validated in vitro, demonstrating that an acidic environment accelerated and increased the release ...
Tópico(s): Nanoparticle-Based Drug Delivery
2024 - Wiley | Advanced Functional Materials
Jackson R. Webster, Judy L. Meyer,
... s00027-019-0619-2Leandro Schlemmer Brasil, Divino Vicente Silverio, Helena Soares Ramos Cabette, Joana Darc Batista, Thiago ...
Tópico(s): Freshwater macroinvertebrate diversity and ecology
1997 - University of Chicago Press | Journal of the North American Benthological Society
Victor Lanza Peralta-Peralta, Silverio Apaza-Apaza, Elisban Uriel Huanca-Quiroz, René Aguilar-Anccota,
... Fusarium spp., causa serias perdidas en tuberculos de papa (Solanum tuberosum L.) almacenados. El objetivo fue evaluar ...
Tópico(s): Plant Pathogens and Fungal Diseases
2021 - Manta Polo de Capacitación; Investigación y Publicación (POCAIP) | Dominio de las Ciencias
Yusimy Reyes, Silverio Andrés Quintana, Maricel Cabrera, Lucas Vázquez, Andrea Alejandra Arrúa Alvarenga, L. Martínez,
... 25:75, en un medio de extracto de papa natural. Cada tratamiento se realizo por duplicado. Las ...
Tópico(s): Algal biology and biofuel production
2016 - | Steviana