Miguel Reyes‐Parada, Angélica Fierro, Patricio Iturriaga‐Vásquez, Bruce K. Cassels,
The recent description of the crystal structures of rat MAO-A and human MAO-B provides an unprecedented framework to elucidate the mechanisms underlying the selective interactions between these proteins and their ligands. The analysis of previous and emerging data, in the light of the structural similarities and differences between both isozymes, allows a better understanding of the requirements that determine the affinity and selectivity of substrates and inhibitors. This augurs a new impulse for ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2005 - Bentham Science Publishers | Current Enzyme Inhibition
Lidia Alejandra Pachón Alonso, Rosa Angélica Parada Sánchez, Arley Zamir Chaparro Cardozo,
En el presente artículo se dan a conocer las formas de razonamiento intuitivo que emplearon los estudiantes del grado 5 de la Institución Educativa Rural del Sur en el aula de clase; para identificar estas formas, se desarrollaron tres etapas, inicialmente se realizó un reconocimiento de la población; en segundo lugar, se observaron y se grabaron algunas clases de asignaturas como español, inglés y matemáticas, en las cuales se identificaron las principales formas de lenguaje cotidiano empleadas ...
Tópico(s): Educational theories and practices
2016 - Pedagogical and Technological University of Colombia | Praxis & Saber
María Elena Mondragón-Parada, Nora Ruiz‐Ordaz, Angélica Tafoya‐Garnica, Cleotilde Juárez‐Ramírez, Everardo Curiel‐Quesada, Juvencio Galı́ndez-Mayer,
Using a successive transfer method on mineral salt medium containing simazine, a microbial community enriched with microorganisms able to grow on simazine was obtained. Afterwards, using a continuous enrichment culture procedure, a bacterial community able to degrade simazine from an herbicide formulation was isolated from a chemostat. The continuous selector, fed with a mineral salt medium containing simazine and adjuvants present in the commercial herbicide formulation, was maintained in operation ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2008 - Springer Science+Business Media | Journal of Industrial Microbiology & Biotechnology
Camila Fernanda Cifuentes Zúñiga, Guisella Alejandra Gaete Villegas, Ismael Morales Ojeda, Claudia Mariela Sepúlveda Saldias, Darynka Angélica Parada Jiménez,
Objective: To determine the predominant risk factors for sexually transmitted diseases in adolescents from a secondary school in Coihueco (Chile) during the second half of 2018. Materials and methods: A cross-sectional descriptive study was conducted with a group of secondary school adolescents during the second half of 2018. A simple random sampling was performed. Data were processed using percentage calculation and entered into tables. Family bond, knowledge and risky behaviors were considered ...
Tópico(s): Public Health and Environmental Issues
2020 - University of San Martín de Porres | Horizonte Médico (Lima)
Diego J. Parada, Angélica Flórez, Urbano Eliécer Gómez Prada,
Este artÃculo presenta el análisis sistémico de los componentes de la seguridad utilizando los lenguajes de la dinámica de sistemas tales como la prosa, el diagrama de influencias, de flujo-nivel, las ecuaciones y los comportamientos. La dinámica de sistemas permite el análisis de la complejidad de los elementos de la seguridad mediante la caracterización de los ciclos de realimentación presentes para el entendimiento, explicación y pronóstico de la misma. Se muestra la utilidad del modelo ...
Tópico(s): Sociology, Governance, and Technology
2018 - Centro de Informacion Tecnologica | Información tecnológica
Universe Leung, Amber L. Simpson, Raphael L. C. Araújo, Mithat Gönen, Conor McAuliffe, Michael I. Miga, Patricia E. Parada, Peter J. Allen, Michael I. D’Angelica, T. Peter Kingham, Ronald P. DeMatteo, Yuman Fong, William R. Jarnagin,
BACKGROUND: After portal vein embolization (PVE), the future liver remnant (FLR) hypertrophies for several weeks. An early marker that predicts a low risk of post-hepatectomy liver failure can reduce the delay to surgery. STUDY DESIGN: Liver volumes of 153 patients who underwent a major hepatectomy (>3 segments) after PVE for primary or secondary liver malignancy between September 1999 and November 2012 were retrospectively evaluated with computerized volumetry. Pre- and post-PVE FLR volume and functional ...
Tópico(s): Liver Disease Diagnosis and Treatment
2014 - Lippincott Williams & Wilkins | Journal of the American College of Surgeons
Alejandra Reyes J., Gonzalo Chorbadjian A., M. Angélica Parada C., Jenny Turrys C., Nieves Bravo C., Carmen G. Araya F.,
Congenital Syphilis: Optimizing the diagnosis in 191 newborn infants of VDRL positive mothersCongenital syphilis is still an important issue in terms of public health.In this prospective study the change in case definition and treatment of congenital syphilis, as well as the addition of a third VDRL to a pregnant woman at her admission to hospital, allowed to improve the detection of congenital syphilis cases to improve, specially in the group of mothers who were infected at the third trimester ...
Tópico(s): Syphilis Diagnosis and Treatment
2004 - SciELO | Revista chilena de infectología
Produção Nacional
Revisado por pares
Thelma Renata Parada Simão, María Angélica Miglino, Jodonai Barbosa da Silva, Concepta McManus, Édson Aparecido Liberti,
Unclaimed corpses were for many years the supply of human material for the study of human anatomy.However, due to improved quality of life and technology, there has been the surround these.Faced with these circumstances, and the impossibility of total replacement of this material by others in training future professionals and the endless dissection technique, the Donation Voluntary Bodies for Anatomical Study is presented as an alternative to capture corpses or who wish to donate your body or part ...
Tópico(s): Anatomy and Medical Technology
2016 - Chilean Society of Anatomy | International Journal of Morphology
Angelica Dias Parada, Fabiane Regina Guimarães Oliveira,
Introdução: Uma Unidade de Alimentação e Nutrição é um local destinado ao preparo e distribuição de refeições, que tende a garantir a qualidade nutricional e fornecer uma refeição segura, segundo as normas higiênico-sanitárias estabelecidas pela legislação. O Brasil, além de ser um dos maiores países produtores de alimentos, também é um dos que mais desperdiçam e milhares de pessoas estão sofrendo com esse problema. O aumento da fome no mundo cresce em ritmo acelerado. Um dos indicadores da quantidade ...
Tópico(s): Food Waste Reduction and Sustainability
2017 - FACULDADE DE MEDICINA DE SÃO JOSÉ DO RIO PRETO | Arquivos de Ciências da Saúde
Nicole Morales‐Camilo, Cristian O. Salas, Claudia Sanhueza, Christian Espinosa‐Bustos, Silvia Sepúlveda‐Boza, Miguel Reyes‐Parada, Fernando D. González‐Nilo, Marcos Caroli Rezende, Angélica Fierro,
A series of chalcones and aurones were synthesized and evaluated in vitro as monoamine oxidase inhibitors (MAOi). Our results show that aurones, which had not been previously reported as MAOi, are MAO-B inhibitors. Thus, both families inhibited selectively the B isoform of MAO in the micromolar range, offering novel scaffolds for the design of new and potent MAO inhibitors. The main structural requirements for their activity were characterized with the aid of 3D-QSAR and docking studies.
Tópico(s): Synthesis and biological activity
2014 - Wiley | Chemical Biology & Drug Design
Pedro Chaná C, Angélica Fierro H, Miguel Reyes‐Parada, Patricio Sáez‐Briones,
There are doubts wether generic medications have the same bioavailability and efficacy compared with the original drugs developed by pharmaceutical companies with research capabilities.To compare the pharmacokinetics and clinical (motor) responses of Sinemet and Grifoparkin (generic carbidopa/levodopa 250/25 mg) in patients with advanced Parkinson's disease.Patients were randomly assigned to Sinemet (15 patients 62 +/- 12 years old; mean disease duration 11 +/- 7 years) or Grifoparkin (15 patients, 64 +/- 11 years ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2003 - Q16635223 | Revista médica de Chile
Bania Catalina Ceballo Mella, Daicy Marioly Fonseca Sanhueza, Naibeth Scarlette Fuenzalida Palma, Lidia Lisette Morales Rodríguez, Darynka Angélica Parada Jiménez, Ismael Morales Ojeda,
Objetivo: Describir la importancia de la enfermera escolar según la percepción de los funcionarios de colegios básicos de una provincia al sur de Chile. Material y Método: Estudio cuantitativo, descriptivo, transversal que, a partir de un universo de 169 funcionarios de 5 colegios públicos y privados, obtuvo una muestra de 126 (75%) personas quienes, posterior a dar su consentimiento informado, respondieron el instrumento "Percepción de la importancia de la enfermera escolar", desde la perspectiva ...
Tópico(s): Child and Adolescent Health
2020 - University of Concepción | Ciencia y enfermería/Ciencia y enfermería
Jonathan Soto-Paz, Angélica Hernandez, Cristian Mejía-Parada, Viviana Mora-Ruiz, Wilson Hernández, Francisco Luna-Guevara, Miguel Casallas-Ojeda, Brayan Alexis Parra-Orobio,
Tópico(s): Multi-Criteria Decision Making
2023 - Springer Science+Business Media | Environmental Processes
Sandra Evely Parada Rico, Angèlica Mayerly Velasco Mèndez, Jorge Enrique Fiallo Leal,
This article is the result of a research project that aimed to characterize the communication skills developed by students who solved problems of seven workshops related to the notions of variation and change within the framework of a pre-calculus laboratory course mediated by interactive mathematical software at a Colombian public university. Data analysis was performed considering the characterization of the skills of interpretation, explanation, and justification, which are fundamental for the ...
Tópico(s): Knowledge Societies in the 21st Century
2023 - Modestum Limited | Eurasia Journal of Mathematics Science and Technology Education
Mauricio Latorre, María Paz Cortés, Dante Travisany, Alex Di Genova, Marko Budinich, Angélica Reyes-Jara, Christian Hödar, Maurício González, Pilar Parada, Roberto A. Bobadilla-Fazzini, Verónica Cambiazo, Alejandro Maass,
This work presents the molecular foundation of a consortium of five efficient bacteria strains isolated from copper mines currently used in state of the art industrial-scale biotechnology. The strains Acidithiobacillus thiooxidans Licanantay, Acidiphilium multivorum Yenapatur, Leptospirillum ferriphilum Pañiwe, Acidithiobacillus ferrooxidans Wenelen and Sulfobacillus thermosulfidooxidans Cutipay were selected for genome sequencing based on metal tolerance, oxidation activity and bioleaching of copper ...
Tópico(s): Corrosion Behavior and Inhibition
2016 - Elsevier BV | Bioresource Technology
Ana María Guzmán D, Sandra Solari S, Marcela Lagos, Helena Poggi, Tomás Sánchez P, Angélica Madrid Q, B. Parada, Juan Carlos Román G, Luis Rodríguez P, Teresa Quiroga G,
An alert value is a result suggesting that the patient is at imminent danger unless appropriate remedial actions begin promptly. Report of alert values (AV) by the clinical laboratories has taken special relevance in recent years due to its contribution to patient's care.To report results of AV informed during 2007 within the Health Network of the Pontificia Universidad Católica de Chile.Analysis of AV recorded in a centralized database of the laboratories of the health network, between January and ...
Tópico(s): Quality and Safety in Healthcare
2009 - Q16635223 | Revista médica de Chile
Sergio Hidalgo, Daniela Molina‐Mateo, Pía Escobedo, Rafaella V. Zárate, Elsa Fritz, Angélica Fierro, Edwin G. Pérez, Patricio Iturriaga‐Vásquez, Miguel Reyes‐Parada, Rodrigo Varas, Nicolás Fuenzalida‐Uribe, Jorge M. Campusano,
A better comprehension on how different molecular components of the serotonergic system contribute to the adequate regulation of behaviors in animals is essential in the interpretation on how they are involved in neuropsychiatric and pathological disorders. It is possible to study these components in "simpler" animal models including the fly Drosophila melanogaster, given that most of the components of the serotonergic system are conserved between vertebrates and invertebrates. Here we decided to ...
Tópico(s): Insect and Arachnid Ecology and Behavior
2017 - American Chemical Society | ACS Chemical Neuroscience
Susan Lühr, Marcelo Vilches‐Herrera, Angélica Fierro, Rona R. Ramsay, Dale E. Edmondson, Miguel Reyes‐Parada, Bruce K. Cassels, Patricio Iturriaga‐Vásquez,
Tópico(s): Adenosine and Purinergic Signaling
2010 - Elsevier BV | Bioorganic & Medicinal Chemistry
Gabriel Vallejos, Angélica Fierro, Marcos Caroli Rezende, Silvia Sepúlveda‐Boza, Miguel Reyes‐Parada,
The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2005 - Elsevier BV | Bioorganic & Medicinal Chemistry
Angélica Fierro, Marcos Caroli Rezende, Silvia Sepúlveda‐Boza, Miguel Reyes‐Parada, Bruce K. Cassels,
The use of heterogeneous basic catalysts (KF, NaHCO 3 ) in the preparation of 2-Aryl-1,3-dinitropropanes from β-nitrostyrenes or benzaldehydes is described, with one example followed kinetically by HPLC analysis of aliquots of the reaction.
Tópico(s): Chemical Synthesis and Reactions
2001 - SAGE Publishing | Journal of Chemical Research
Adriana P. Corredor-Figueroa, Luz A. Parada, José J. Fuentes, Judith Helena Prieto,
... administration; writing—original draft; writing—review & editing. Luz Angélica Parada: Formal analysis; investigation; methodology; resources; writing—review & editing. ...
Tópico(s): COVID-19 diagnosis using AI
2022 - Wiley | Health Science Reports
Alberto Macías‐Flores, Angélica Tafoya‐Garnica, Nora Ruiz‐Ordaz, Angélica Salmerón‐Alcocer, Cleotilde Juárez‐Ramírez, Deifilia Ahuatzi‐Chacón, María Elena Mondragón-Parada, Juvencio Galı́ndez-Mayer,
Tópico(s): Enzyme-mediated dye degradation
2009 - Springer Science+Business Media | World Journal of Microbiology and Biotechnology
Marcelo Vilches‐Herrera, Juan Miranda-Sepúlveda, Marco Rebolledo-Fuentes, Angélica Fierro, Susan Lühr, Patricio Iturriaga‐Vásquez, Bruce K. Cassels, Miguel Reyes‐Parada,
A series of naphthylisopropylamine and N-benzyl-4-methylthioamphetamine derivatives were evaluated as monoamine oxidase inhibitors. Their potencies were compared with those of a series of amphetamine derivatives, to test if the increase of electron richness of the aromatic ring and overall size of the molecule might improve their potency as enzyme inhibitors. Molecular dockings were performed to gain insight regarding the binding mode of these inhibitors and rationalize their different potencies. ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2009 - Elsevier BV | Bioorganic & Medicinal Chemistry
Alejandra Gallardo‐Godoy, Angélica Fierro, Thomas H. McLean, Mariano Castillo, Bruce K. Cassels, Miguel Reyes‐Parada, David E. Nichols,
A series of phenethylamine derivatives with various ring substituents and with or without N-methyl and/or C-α methyl or ethyl groups was synthesized and assayed for their ability reversibly to inhibit monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). Several compounds showed potent and selective MAO-A inhibitory activity (IC50 in the submicromolar range) but none showed appreciable activity toward MAO-B. A three-dimensional quantitative structure−activity relationship study for MAO-A inhibition ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2005 - American Chemical Society | Journal of Medicinal Chemistry
Claudio Hurtado‐Guzmán, Angélica Fierro, Patricio Iturriaga‐Vásquez, Silvia Sepúlveda‐Boza, Bruce K. Cassels, Miguel Reyes‐Parada,
(+/-)-4-Methylthioamphetamine (MTA) was resolved into its enantiomers, and a series of N-alkyl derivatives of the parent compound, as well as its alpha-ethyl analogue, were prepared. The monoamine oxidase (MAO) inhibitory properties of these substances were evaluated in vitro, using a crude rat brain mitochondrial suspension as the source of enzyme. All compounds produced a selective, reversible and concentration-related inhibition of MAO-A. (+)-MTA proved to be the most potent inhibitor studied, while ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2003 - Taylor & Francis | Journal of Enzyme Inhibition and Medicinal Chemistry
Julian L. Wissner, José Carlos Parada-Fabián, Norma Angélica Márquez-Velázquez, Wendy Escobedo‐Hinojosa, Susana P. Gaudêncio, Alejandra Prieto‐Davó,
Water-filled sinkholes known locally as cenotes, found on the Yucatán Peninsula, have remarkable biodiversity. The primary objective of this study was to explore the biotechnological potential of Gram-positive cultivable bacteria obtained from sediment samples collected at the coastal cenote Pol-Ac in Yucatán, Mexico. Specifically, the investigation aimed to assess production of hydrolytic enzymes and antimicrobial compounds. 16 S rRNA gene sequencing led to the identification of 49 Gram-positive ...
Tópico(s): Genomics and Phylogenetic Studies
2024 - Springer Science+Business Media | Microbial Ecology
Angélica Fierro, Mauricio Osorio, Bruce K. Cassels, Dale E. Edmondson, Silvia Sepúlveda‐Boza, Miguel Reyes‐Parada,
Four enantiomerically pure (S)-4-alkylthioamphetamine derivatives were evaluated as monoamine oxidase (MAO) inhibitors using the human and rat isoforms of the enzyme. Molecular dockings were performed in order to gain insights regarding the binding mode of these inhibitors. All compounds were potent and selective MAO-A inhibitors although different rank orders of potencies were observed against the enzymes from different species. This behavior can be rationalized on the basis of different binding ...
Tópico(s): Cyclopropane Reaction Mechanisms
2007 - Elsevier BV | Bioorganic & Medicinal Chemistry
Andrea Angélica Bernal Figueroa, Claudia Johana Beltrán Parada, Andrés Felipe Márquez Márquez,
Este artículo presenta una revisión de aspectos básicos de la Producción Más Limpia (PML) como estrategia ambiental preventiva, la cual se integra a los procesos productivos con el fin de hacerlos más eficientes ambientalmente en cuanto a la utilización de recursos y materias primas, entre otros. Se mencionan aspectos generales en cuanto al impacto ambiental en Colombia enfocado en los sistemas productivos, origen y evolución general del concepto, así como definición, aspectos generales, beneficios ...
Tópico(s): Public Health and Environmental Issues
2017 - | I3+
Amber L. Simpson, Lauryn B. Adams, Peter J. Allen, Michael I. D’Angelica, Ronald P. DeMatteo, Yuman Fong, T. Peter Kingham, Universe Leung, Michael I. Miga, Patricia E. Parada, William R. Jarnagin, Richard Kinh Gian,
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2014 - Lippincott Williams & Wilkins | Journal of the American College of Surgeons
Charles Bermúdez, Fernando Pereira, Diana Trejos-Gallego, Angélica Pérez, Milena Puentes, Lina María López, C. García, Esperanza Moncada Parada, Martha Elena Muñoz Peláez, Justo Olaya Ramírez, Mauricio Chona, Andrés Becerra, Diana Cárdenas,
The World Health Orga-nization declared the disease COVID-19 caused by the SARS-CoV-2 virus as a pandemic on March 11, 2020. In Colombia, the first case was registered on March 6, 2020. Unprecedented, this pandemic presents challenges for patients and healthcare systems worldwide. The objective of this document is to offer recommendations on nutrition interventions in hospitalized patients with SARS-CoV-2 infection with special emphasis on the critically ill patient.
Tópico(s): Clinical Nutrition and Gastroenterology
2020 - | Revista de Nutrición Clínica y Metabolismo