Jae-Seung Park, Sneha Surendran, Lisa M. Kamendulis, Núria Morral,
Primary hepatocytes are the best resource for in vitro studies directed at understanding hepatic processes at the cellular and molecular levels, necessary for novel drug development to treat highly prevalent diseases such as non-alcoholic steatohepatitis, cardiovascular disease and type 2 diabetes. There is a need to identify simple methods to genetically manipulate primary hepatocytes and conduct functional studies with plasmids, small interfering RNA (siRNA) or microRNA (miRNA). New lipofection ...
Tópico(s): Viral gastroenteritis research and epidemiology
2011 - BioMed Central | BMC Research Notes
Dipak R. Patel, Wei Li, Jae-Seung Park, M. Hanief Sofi, Tania Gourley, G Hangoc, Mark H. Kaplan, Cheong‐Hee Chang,
We generated mice expressing a human type III CIITA transgene (CIITA Tg) under control of the CD4 promoter to study the role of CIITA in CD4 T cell biology. The transgene is expressed in peripheral CD4 and CD8 T cells, as well as in thymocytes. When CD4 T cells were differentiated towards the Th2 lineage, both control and CIITA Tg Th2 cells expressed similar levels of Th2 cytokines. Th1 cells from control and CIITA Tg mice cells produced comparable levels of IFN-γ. CIITA Tg Th1 cells also expressed ...
Tópico(s): Immunotherapy and Immune Responses
2005 - Elsevier BV | Cellular Immunology
Il Hwan Choi, Young Min Shin, Jae Seung Park, Moo Sam Lee, Eue Hyeog Han, Ok Hee Chai, Shun Young Im, T Y Ha, Hern-Ku Lee,
Mast cells have long been believed to be the central effector cells in the development of immunoglobulin (Ig)E-dependent anaphylaxis. In this study, we investigated the role of mast cells in IgE-dependent hapten-induced active fatal anaphylaxis using mast cell–deficient WBB6F1- W/Wv (W/Wv) and congenic normal (+/+) mice. Although a 5-min delay in shock signs and death were observed in W/Wv mice, 100% fatal reactions to penicillin V (Pen V) occurred in both +/+ and W/Wv mice. Administration of monoclonal anti– ...
Tópico(s): Asthma and respiratory diseases
1998 - Rockefeller University Press | The Journal of Experimental Medicine
Jae Seung Park, Sang Hoon Song, Jun Bong Choi, Young Suk Kim, Soon Hee Kwon, Young‐Seo Park,
Tópico(s): Phytochemicals and Antioxidant Activities
2014 - Springer Science+Business Media | Food Science and Biotechnology
Ki Young Hong, June Hyuk Lee, Sung‐Woo Park, Jae Hak Joo, Do Jin Kim, Sung Heuk Moon, Soo Taek Uh, Yong Hoon Kim, Choon‐Sik Park, Jae Seung Park,
Background Bronchial asthma is a clinical syndrome characterized by reversibility of airway obstruction. However, many asthmatics have evidence of residual airway obstruction. It has become evident that the repair of the chronic inflammatory process can lead to various irreversible changes. It is generally accepted that the most common cause for the change is cigarette smoking but it is controversial whether asthma progresses to emphysema. High resolution computed tomography (HRCT) is more sensitive ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2002 - Korean Association of Internal Medicine | The Korean Journal of Internal Medicine
Bo‐In Park, Seunggun Yu, Yoonjung Hwang, So‐Hye Cho, Jae‐Seung Lee, Cheolmin Park, Doh-Kwon Lee, Seung Yong Lee,
Highly crystalline Fe 2 GeS 4 nanocrystals were synthesized via a facile, solvent-free mechanochemical process. The post-annealed Fe 2 GeS 4 nanocrystals showed an absorption edge at 1.43 eV and a PL emission at 1.41 eV.
Tópico(s): Iron-based superconductors research
2014 - Royal Society of Chemistry | Journal of Materials Chemistry A
María Rosario Capeding, Edison Alberto, Arijit Sil, Tarun Saluja, Samuel Teshome, Deok Ryun Kim, Ju Yeon Park, Jae Seung Yang, Suchada Chinaworapong, Jiwook Park, Sue-Kyoung Jo, Yun Chon, Seon-Young Yang, Dong Soo Ham, Ji Hwa Ryu, Julia Lynch, Jérôme H. Kim, Hun Kim, Jean‐Louis Excler, T. Anh Wartel, Sushant Sahastrabuddhe,
Typhoid fever remains an important public health problem in developing countries and is endemic in many parts of Asia and Africa where the incidence of disease typically peaks in school-aged children. Age restrictions and other limitations of existing oral live-attenuated typhoid and parenteral Vi polysaccharide vaccines have triggered the development of Vi conjugate vaccines with improved immunological properties, use in younger age range, and longer durability of protection. We present the safety, ...
Tópico(s): Escherichia coli research studies
2019 - Elsevier BV | Vaccine
María Rosario Capeding, Arijit Sil, Birkneh Tilahun Tadesse, Tarun Saluja, Samuel Teshome, Edison Alberto, Deok Ryun Kim, Eun Lyeong Park, Ju Yeon Park, Jae Seung Yang, Suchada Chinaworapong, Jiwook Park, Sue-Kyoung Jo, Yun Chon, Seon-Young Yang, Ji Hwa Ryu, Inho Cheong, Kyuyoung Shim, Yoonyeong Lee, Hun Kim, Julia Lynch, Jérôme H. Kim, Jean‐Louis Excler, T. Anh Wartel, Sushant Sahastrabuddhe,
Typhoid causes significant mortality among young children in resource-limited settings. Conjugate typhoid vaccines could significantly reduce typhoid-related child deaths, but only one WHO-prequalified typhoid conjugate vaccine exists for young children. To address this gap, we investigated the safety, immunogenicity and dose-scheduling of Vi-DT typhoid conjugate vaccine among children aged 6-23 months.In this single center, observer blind, phase II trial, participants were randomly assigned (2:2: ...
Tópico(s): Vibrio bacteria research studies
2020 - Elsevier BV | EClinicalMedicine
María Rosario Capeding, Samuel Teshome, Tarun Saluja, Khalid Syed, Deok Ryun Kim, Ju Yeon Park, Jae Seung Yang, Yang Hee Kim, Jiwook Park, Sue-Kyoung Jo, Yun Chon, Sudeep Kothari, Seon-Young Yang, Dong Soo Ham, Ji Hwa Ryu, Hee-Seong Hwang, Ju-Hwan Mun, Julia Lynch, Jérôme H. Kim, Hun Kim, Jean‐Louis Excler, Sushant Sahastrabuddhe,
Typhoid fever remains a major public health problem in low- and middle-income countries where children aged 2–14 years bear the greatest burden. Vi polysaccharide is poorly immunogenic in children <2 years of age, and protection in adults is modest. The limitations of Vi polysaccharide vaccines can be overcome by conjugation of the Vi to a carrier protein. A typhoid conjugate vaccine composed of Vi polysaccharide conjugated to diphtheria toxoid (Vi-DT) has been developed. The Phase I study results ...
Tópico(s): Escherichia coli research studies
2018 - Elsevier BV | Vaccine
Myungchan Park, Seong Cheol Kim, Jae‐Seung Chung, Sang Hyun Park, Seok San Park, Sung Jin Oh, Donghoon Lee, Koon Ho Rha, Cheol Kyu Oh,
We report a case of synchronous rectal and prostate cancer treated successfully with simultaneous da Vinci robotic-assisted low anterior resection of the rectum and robotic-assisted laparoscopic radical prostatectomy to address both cancers.Recently, minimally invasive surgical techniques using da Vinci robot® system (Intuitive Surgical, Sunnyvale, USA) were introduced as curative surgical modality of prostate and rectal malignancies. Herein, we report an initial case of simultaneous robotic low ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2016 - Springer International Publishing | SpringerPlus
Moon Seong Baek, Sang‐Min Lee, Chi Ryang Chung, Woo Hyun Cho, Young‐Jae Cho, Sunghoon Park, So-My Koo, Jae Seung Jung, Seung Yong Park, Youjin Chang, Byung Ju Kang, Jung‐Hyun Kim, Jin Young Oh, So Hee Park, Jung‐Wan Yoo, Yun Su Sim, Sang‐Bum Hong,
Although the utilization of extracorporeal membrane oxygenation (ECMO) is increasing and its technology is evolving, only a few epidemiologic reports have described the uses and outcomes of ECMO. The aim of this study was to investigate the changes in utilization and survival rate in patients supported with ECMO for severe respiratory failure in Korea. This was a multicenter study on consecutive patients who underwent ECMO across 16 hospitals in Korea. The records of all patients who required ECMO ...
Tópico(s): Cardiac Arrest and Resuscitation
2019 - BioMed Central | Critical Care
Jong Min An, Sangrim Kang, Eugene Huh, Yejin Kim, Dahae Lee, Hyejung Jo, Joonyoung F. Joung, Veronica Jihyun Kim, Ji Yeoun Lee, Yun Sik Dho, Yuna Jung, Junho K. Hur, Chan Park, Junyang Jung, Youngbuhm Huh, Ja‐Lok Ku, Sojin Kim, Tamrin Chowdhury, Sungnam Park, Jae Seung Kang, Myung Sook Oh, Chul‐Kee Park, Dokyoung Kim,
A fluorescent molecular probe for the identification of glioblastoma is developed. The probe allows the tracing of the cysteine (Cys) level, which is recognized as a new biomarker of GBM.
Tópico(s): Supramolecular Self-Assembly in Materials
2020 - Royal Society of Chemistry | Chemical Science
Jae-Seung Park, Yong Jin Choi, Vicki J. Siegrist, Yoo‐Seung Ko, Won Kyoo Cho,
Tópico(s): Sphingolipid Metabolism and Signaling
2007 - Springer Science+Business Media | Pflügers Archiv - European Journal of Physiology
Myung‐Sunny Kim, Young‐Pyo Cheong, Hong‐Seob So, Kang‐Min Lee, Yong Son, Chang‐Soo Lee, Jae‐Seung Yun, Raekil Park,
Nociceptin/orphanin FQ (N/OFQ), an endogenous ligand for opioid receptor-like (ORL1) receptor, transduces signaling cascades implicated in MAPK, PKC, PLC, and calcium, etc. This study was designed to investigate the intracellular signaling mechanism of N/OFQ in human dopaminergic neuroblastoma SH-SY5Y cells. N/OFQ rapidly induced the phosphorylation of CREB, which was significantly suppressed by pretreatment of PKA inhibitor, but not by MAPK inhibitors. It also time-dependently increased the phosphorylation ...
Tópico(s): Hypothalamic control of reproductive hormones
2002 - Elsevier BV | Biochemical and Biophysical Research Communications
JongSuk Choi, Jae Seung Bang, Kang Park, Mincheol Whang,
Speller UI systems tend to be less accurate because of individual variation and the noise of EEG signals. Therefore, we propose a new method to combine the EEG signals and gaze-tracking. This research is novel in the following four aspects. First, two wearable devices are combined to simultaneously measure both the EEG signal and the gaze position. Second, the speller UI system usually has a 6 × 6 matrix of alphanumeric characters, which has disadvantage in that the number of characters is limited ...
Tópico(s): Neuroscience and Neural Engineering
2013 - Multidisciplinary Digital Publishing Institute | Sensors
One of the most dominant candidates for the paired quantum Hall (QH) state at filling factor $\ensuremath{\nu}=5/2$ is the Moore-Read (MR) Pfaffian state. A salient problem, however, is that it does not occur exactly at the Coulomb interaction, but rather at a modified interaction, which favors particle-hole-symmetry breaking. In an effort to find a better state, in this work, we investigate the possible connection between the paired QH state and the antisymmetrized bilayer ground state, which is inspired ...
Tópico(s): Topological Materials and Phenomena
2015 - American Physical Society | Physical Review B
Woohyung Lee, Minyoung Oh, Jae Seung Kim, Yejong Park, Jaewoo Kwon, Eunsung Jun, Ki Byung Song, Jae Hoon Lee, Dae Wook Hwang, Changhoon Yoo, Kyu‐pyo Kim, Jae Ho Jeong, Heung-Moon Chang, Baek‐Yeol Ryoo, Seo Young Park, Song Cheol Kim,
The optimal prognostic markers for neoadjuvant chemotherapy in patients with borderline resectable or locally advanced pancreatic cancer are not yet established.Patients who received neoadjuvant chemotherapy prior to surgery and underwent FDG-PET/CT between July 2012 and December 2017 were included. Metabolic parameters including standardized uptake value (SUV), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) on PET/CT, and response evaluations using PERCIST criteria, were investigated ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2021 - Oxford University Press | British journal of surgery
Jae Seung Lee, Sungjin Park, Sanghoon Jung,
Crime prevention through environmental design (CPTED) has become a popular urban planning approach to preventing crime and mitigating fear of crime through the improvement of physical neighborhood environments. CPTED is widely used to improve deteriorated neighborhoods that suffer from crime. However, few studies have empirically examined the complex relationships among CPTED, fear of crime, and active living. Our study, therefore, investigated the effects of CPTED measures on walking frequency and ...
Tópico(s): Korean Urban and Social Studies
2016 - Multidisciplinary Digital Publishing Institute | Sustainability
Jae Seung Kang, Taesung Park, Youngmin Han, Seung‐Yeon Lee, Heeju Lim, Hyeongseok Kim, Se Hyung Kim, Wooil Kwon, Sun‐Whe Kim, Jin‐Young Jang,
Purpose: The 2017 international consensus guidelines (ICG) for intraductal papillary mucinous neoplasm (IPMN) of the pancreas were recently released.Important changes included the addition of worrisome features such as elevated serum CA 19-9 and rapid cyst growth (>5 mm over 2 years).We aimed to clinically validate the 2017 ICG and compare the diagnostic performance between the 2017 and 2012 ICG.Methods: This was a retrospective cohort study.During January 2000-January 2017, patients who underwent complete ...
Tópico(s): Gallbladder and Bile Duct Disorders
2019 - | Annals of Surgical Treatment and Research
Jae Seung Kang, Taesung Park, Youngmin Han, Seungyeon Lee, Jae Ri Kim, Hongbeom Kim, Wooil Kwon, Sun‐Whe Kim, Jin Seok Heo, Seong Ho Choi, Dong Wook Choi, Song Cheol Kim, Tae Ho Hong, Dong Sup Yoon, Joon Seong Park, Sang‐Jae Park, Sung‐Sik Han, Sae-Byeol Choi, Joo Seop Kim, Chang-Sup Lim, Jin‐Young Jang,
Although several prediction models for the occurrence of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD) exist, all were established using Western cohorts. Large-scale external validation studies in Eastern cohorts that consider demographic variables including lower body mass index (BMI) are scarce. The purpose of this study was to externally validate POPF prediction models using nationwide large-scale Korean cohorts.Nine tertiary university hospitals in the Republic of Korea ...
Tópico(s): Colorectal Cancer Screening and Detection
2019 - AME Publishing Company | HepatoBiliary Surgery and Nutrition
Jun Namkung, Joon Hyung Sohn, Jae Seung Chang, Sangwook Park, Jang‐Young Kim, Sang Baek Koh, In Deok Kong, Kyu‐Sang Park,
Background Despite being an anti-obesity hepatokine, the levels of serum angiopoietin-like 6 (ANGPTL6) are elevated in various metabolic diseases. Thus, ANGPTL6 expression may reflect metabolic burden and may have compensatory roles. This study investigated the association between serum ANGPTL6 levels and new-onset metabolic syndrome. Methods In total, 221 participants without metabolic syndrome were randomly selected from a rural cohort in Korea. Baseline serum ANGPTL6 levels were measured using ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2019 - Korean Diabetes Association | Diabetes & Metabolism Journal
Bo‐In Park, Yoonjung Hwang, Seung Yong Lee, Jae‐Seung Lee, Jong-Ku Park, Jeung‐hyun Jeong, Jin Young Kim, BongSoo Kim, So‐Hye Cho, Doh-Kwon Lee,
Cu 2 ZnSnS 4 synthesized by a solvent-free mechanochemical process were successfully applied to fabricate Cu 2 ZnSnSe 4 solar cells with efficiencies over 6%.
Tópico(s): Copper-based nanomaterials and applications
2014 - Royal Society of Chemistry | Nanoscale
Hye Won Lee, Myung‐Soo Choo, Jeong Gu Lee, Choal Hee Park, Jae‐Seung Paick, Jeong Zoo Lee, Deok Hyun Han, Won Hee Park, Kyu‐Sung Lee,
To investigate the efficacy and safety of desmopressin in patients with mixed nocturia, Patients aged ≥ 18 yr with mixed nocturia (≥ 2 voids/night and a nocturnal polyuria index [NPi] >33% and a nocturnal bladder capacity index [NBCi] >1) were recruited. The optimum dose of oral desmopressin was determined during a 3-week dose-titration period and the determined dose was maintained for 4 weeks. The efficacy was assessed by the frequency-volume charts and the sleep questionnaire. The primary endpoint was ...
Tópico(s): Urinary Tract Infections Management
2010 - Korean Academy of Medical Sciences | Journal of Korean Medical Science
Jae‐Seung Paick, K. Park, Sang Wan Kim, Jung‐Won Park, J.J. Kim, M.S. Kim, Jae Young Park,
We investigated hypoxia inducible factor-1α (HIF-1α), connective tissue growth factor (CTGF) expression and fibrosis in the testis of rats with surgically induced varicocele.A total of 47 adult male Sprague-Dawley rats were arranged in 3 groups, namely group 1 (varicocele operation 4 weeks ago, n=10; sham operation 4 weeks ago, n=5), group 2 (8 weeks, n=11; n=5), and group 3 (12 weeks, n=11; n=5). The rats in every group underwent bilateral orchiectomy 4, 8, and 12 weeks after the operations, respectively. ...
Tópico(s): Sperm and Testicular Function
2012 - Elsevier BV | Actas Urológicas Españolas
Tae‒Geun Gweon, Yoo Jin Lee, Kyeong Ok Kim, Sung Kyun Yim, Jae Seung Soh, Seung Young Kim, Jae Jun Park, Seung Yong Shin, Tae Hee Lee, Chang Hwan Choi, Young‐Seok Cho, Dongeun Yong, Jin-Won Chung, Kwang Jae Lee, Oh Young Lee, Myung‐Gyu Choi, Miyoung Choi,
... Jin Lee, Kyeong Ok Kim, Sung Kyun Yim, Jae Seung Soh, Seung Young Kim, Jae Jun Park, Seung Yong Shin, Tae Hee Lee, Chang Hwan ...
Tópico(s): Microscopic Colitis
2022 - The Korean Society of Neurogastroenterology and Motility | Journal of Neurogastroenterology and Motility
Sae Chul Kim, Jong Kwan Park, Sae Woong Kim, Sung Won Lee, Tai Young Ahn, Je Jong Kim, Jae‐Seung Paick, Nam Cheol Park, Kwangsung Park, Kweon Sik Min, Stephen R. Kraus, Roberta J. Secrest, Albert Elion‐Mboussa, Lars Viktrup,
Objectives: Assess the efficacy and safety of once‐daily tadalafil or tamsulosin versus placebo during 12 weeks on lower urinary tract symptoms (LUTS) in Korean men with benign prostatic hyperplasia (BPH). Methods: Following a 4‐week placebo run‐in period, 151 Korean men were randomly assigned to receive once‐daily tadalafil 5 mg, tamsulosin 0.2 mg, or placebo for 12 weeks. Results: The International Prostate Symptom Score (IPSS) least squares mean changes from baseline to endpoint were numerically ...
Tópico(s): Sexual function and dysfunction studies
2011 - Wiley | LUTS Lower Urinary Tract Symptoms
Yoonjung Hwang, Bo‐In Park, Byung Seok Lee, Jin Young Kim, Jeung‐hyun Jeong, Honggon Kim, Min Jae Ko, BongSoo Kim, Hae Jung Son, Seung Yong Lee, Jae‐Seung Lee, Jong-Ku Park, So‐Hye Cho, Doh-Kwon Lee,
Kesterite Cu2ZnSnSe4 (CZTSe) thin films prepared by the selenization of mechanochemically synthesized Cu2ZnSnS4 (CZTS) nanocrystal films are systematically investigated as a function of the annealing time in terms of the phase purity, microstructure, composition, and device characteristics. It is shown that selenization for an extended time does not cause a noticeable amount of Sn loss or segregation of Zn-rich layers. Thus, the prolonged annealing leads to improvements (reduction) in the shunt conductance, ...
Tópico(s): Copper-based nanomaterials and applications
2014 - American Chemical Society | The Journal of Physical Chemistry C
Daeho Cho, Jae Seung Kang, Jong Hoon Park, Young‐In Kim, Eunsil Hahm, June-Chul Lee, Yoolhee Yang, Jun-Ho Jeon, Hyunkeun Song, Hyun-Jeong Park, Tae-Sung Kim, Saic Pang, Jong Kyu Woo, Young Il Hwang, Wang Jae Lee,
Based on our recent observation that enhanced IL-18 expression positively correlates with malignant skin tumors, such as SCC and melanoma, we examined the possible role of UVB, known to be associated with skin cancer development, in the enhancement of IL-18 production using primary human epidermal keratinocytes and human keratinocyte cell line HaCaT. After cells were exposed to UVB irradiation in vitro, IL-18 production was examined by Northern blot analysis and ELISA, and it was found that IL-18 ...
Tópico(s): Immunotherapy and Immune Responses
2002 - Elsevier BV | Biochemical and Biophysical Research Communications
Jun‐Koo Kang, Jae-Seung Baek, Kyung Suh Park,
We show that during the 1997 Korean financial crisis, chaebol firms with higher ownership concentration by unaffiliated investors experience a smaller reduction in their share value. Firms with higher disclosure quality and alternative sources of external financing also suffer less. In contrast, chaebol firms with concentrated ownership by controlling family shareholders experience a larger drop in the value of their equity. Firms in which the controlling shareholders' voting rights exceed their ...
Tópico(s): Banking stability, regulation, efficiency
2003 - RELX Group (Netherlands) | SSRN Electronic Journal
Jae‐Seung Paick, Jae Young Park, Dal Woo Park, Kwanjin Park, Hwancheol Son, Soo Woong Kim,
We analyzed our experience with repeat microsurgical vasovasostomy after failed vasovasostomy and elucidate the possible predictors of surgical outcome.We evaluated 62 repeat vasectomy reversal cases with followup data available. Regardless of the intraoperative observation of sperm in the vasal fluid bilateral microsurgical 2-layer vasovasostomy was performed when surgically possible. Of these 62 patients 60 (97%) underwent bilateral (58) or unilateral (2) vasovasostomy and 2 (3%) underwent unilateral ...
Tópico(s): Ureteral procedures and complications
2003 - Lippincott Williams & Wilkins | The Journal of Urology