Eun Hee Han, Jin‐Young Min, Shin-Ae Yoo, Sung-Joon Park, Yun-Jeong Choe, Hee Sub Yun, Zee‐Won Lee, Sun Woo Jin, Hyung Gyun Kim, Hye Gwang Jeong, Hyun Kyoung Kim, Nam Doo Kim, Young‐Ho Chung,
... Young Min 1, 3, * , Shin-Ae Yoo 1 , Sung-Joon Park 1 , Yun-Jeong Choe 1, 2 , Hee Sub ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2017 - Impact Journals LLC | Oncotarget
Michael P. Menden, Dennis Wang, Mike J. Mason, Bence Szalai, Krishna C. Bulusu, Yuanfang Guan, Thomas Yu, Jaewoo Kang, Minji Jeon, Russ Wolfinger, Tin Nguyen, Mikhail Zaslavskiy, Jordi Abante, Barbara Schmitz Abecassis, Nanne Aben, Delasa Aghamirzaie, Tero Aittokallio, Farida S. Akhtari, Bissan Al‐Lazikani, Tanvir Alam, Amin Allam, Chad H. G. Allen, Mariana Pelicano de Almeida, Doaa Altarawy, Vinícius M. Alves, Alicia Amadoz, Benedict Anchang, Albert A. Antolín, Jeremy R. Ash, V. Aznar, Wail Ba-Alawi, Moeen Bagheri, Vladimir B. Bajić, G. C. Ball, Pedro J. Ballester, Delora Baptista, Christopher Bare, Mathilde Bateson, Andreas Bender, Denis Bertrand, Bhagya K. Wijayawardena, Keith A. Boroevich, Evert Bosdriesz, Salim Bougouffa, Gergana Bounova, Thomas Brouwer, Barbara M. Bryant, Manuel Calaza, Alberto Calderone, Stefano Calza, Stephen J. Capuzzi, José Carbonell‐Caballero, Yichao Li, Hannah Carter, Luisa Castagnoli, Remzi Çelebi, Gianni Cesareni, Hyeokyoon Chang, Guocai Chen, Hao Chen, Huiyuan Chen, Lijun Cheng, Ariel Chernomoretz, Davide Chicco, Kwang‐Hyun Cho, Sung‐Hwan Cho, Daeseon Choi, Jaejoon Choi, Kwanghun Choi, Min‐Soo Choi, Martine De Cock, Elizabeth A. Coker, Isidro Cortés‐Ciriano, Miklós Cserző, Cankut Çubuk, Charles Curtis, Dries Van Daele, Cuong Cao Dang, Tjeerd M. H. Dijkstra, Joaquı́n Dopazo, Sorin Drăghici, Anastasios Drosou, Michel Dumontier, Friederike Ehrhart, Fatma-Elzahraa Eid, Mahmoud ElHefnawi, Haitham Elmarakeby, Bo van Engelen, H. Billur Engin, Iwan J. P. de Esch, Chris T. Evelo, André O. Falcão, Sherif Farag, Carlos Fernández-Lozano, Kathleen M. Fisch, Åsmund Flobak, Chiara Fornari, Amir Foroushani, Donatien Chedom Fotso, Denis Fourches, Stephen Friend, Arnoldo Frigessi, Feng Gao, Xiaoting Gao, Jeffrey M. Gerold, Pierre Gestraud, Samik Ghosh, Jussi Gillberg, Antonia Godoy‐Lorite, Elizabeth Godynyuk, Adam Godzik, Anna Goldenberg, David Gómez-Cabrero, Mehmet Gönen, Chris de Graaf, Harry Gray, Maxim Grechkin, Roger Guimerà, Emre Güney, Benjamin Haibe‐Kains, Young-Hyun Han, Takeshi Hase, Di He, Liye He, Lenwood S. Heath, Kristoffer H. Hellton, Manuela Helmer‐Citterich, Marta R. Hidalgo, Daniel Hidru, Steven M. Hill, Sepp Hochreiter, Seungpyo Hong, Eivind Hovig, Ya-Chih Hsueh, Zhiyuan Hu, Justin K. Huang, R. Stephanie Huang, László Hunyady, Jinseub Hwang, Tae Hyun Hwang, Woochang Hwang, Yongdeuk Hwang, Olexandr Isayev, Oliver Bear Don’t Walk, John Jack, Samad Jahandideh, Jiadong Ji, Yousang Jo, Piotr J. Kamola, Georgi K. Kanev, Loukia Georgiou Karacosta, Mostafa Karimi, Samuel Kaski, Marat D. Kazanov, Abdullah M. Khamis, Suleiman A. Khan, Narsis A. Kiani, Allen Kim, Jin-Han Kim, Juntae Kim, Kiseong Kim, Kyung‐Hee Kim, Sunkyu Kim, Yongsoo Kim, Yunseong Kim, Paul Kirk, Hiroaki Kitano, Günter Klambauer, David A. Knowles, Melissa E. Ko, Alvaro Köhn‐Luque, Albert J. Kooistra, Mélaine A. Kuenemann, Martin Kuiper, Christoph Kurz, Mijin Kwon, Twan van Laarhoven, Astrid Lægreid, Simone Lederer, Heewon Lee, Jeon Lee, Yun Woo Lee, Eemeli Lepp aho, Richard A. Lewis, Jing Li, Lang Li, James Liley, Weng Khong Lim, Chieh Hubert Lin, Yiyi Liu, Yosvany López, Joshua Low, Artem Lysenko, Daniel Machado, Neel S. Madhukar, Dries De Maeyer, Ana Belén Malpartida, Hiroshi Mamitsuka, Francesco Marabita, Kathleen Marchal, Pekka Marttinen, Daniel J. Mason, Alireza Mazaheri, Arfa Mehmood, Ali Mehreen, Magali Michaut, Ryan A. Miller, Costas Mitsopoulos, Dezső Módos, Marijke Van Moerbeke, Keagan Moo, Alison A. Motsinger‐Reif, Rajiv Movva, Sebastian Muraru, Eugene Muratov, Mushthofa Mushthofa, Niranjan Nagarajan, Sigve Nakken, Aritro Nath, Pierre Neuvial, Richard Newton, Ning Zheng, Carlos De Niz, Baldo Oliva, Catharina Olsen, Antonio Palmeri, Bhawan Panesar, Stavros Papadopoulos, Jaesub Park, Seonyeong Park, Sung‐Joon Park, Yudi Pawitan, Daniele Peluso, Sriram Pendyala, Jian Peng, Livia Perfetto, S Pirro, Sylvia K. Plevritis, Regina Politi, Hoifung Poon, Eduard Porta‐Pardo, Isak Prellner, Kristina Preuer, Miguel Ángel Pujana, Ricardo Ramnarine, John E. Reid, Fabien Reyal, Sylvia Richardson, Camir Ricketts, Linda Rieswijk, Miguel Rocha, Carmen Rodríguez‐Gonzálvez, Kyle R. Roell, Daniel M. Rotroff, Julian R. de Ruiter, Ploy Rukawa, Benjamin Sadacca, Zhaleh Safikhani, Fita Safitri, Marta Sales‐Pardo, Sebastian Sauer, M. Schlichting, José A. Seoane, Jordi Serra, Ming-Mei Shang, Alok Sharma, Hari M. Sharma, Yang Shen, M. Shiga, Moonshik Shin, Ziv Shkedy, Kevin E. Shopsowitz, Sam Sinai, Dylan Skola, Petr Smirnov, Izel Fourie Soerensen, Peter Borgen Soerensen, Je-Hoon Song, Sang Ok Song, Othman Soufan, Andreas Spitzmueller, Boris Steipe, Chayaporn Suphavilai, Sergio Pulido Tamayo, David Tamborero, Jing Tang, Ziaurrehman Tanoli, Marc Tarrés-Deulofeu, Jesper Tegnér, Liv Thommesen, Seyed Ali Madani Tonekaboni, Hong Tran, Ewoud De Troyer, Amy Truong, Tatsuhiko Tsunoda, Gábor Turu,
Abstract The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate ...
Nature Portfolio
A. Saintonge, C. D. Wilson, Ting Xiao, Lihwai Lin, Ho Seong Hwang, Tomoka Tosaki, Martin Bureau, Phil Cigan, Christopher Clark, D. L. Clements, I. De Looze, T. E. Dharmawardena, Yang Gao, W. K. Gear, J. Greenslade, Isabella Lamperti, Jong Chul Lee, Cheng Li, M. J. Michałowski, Angus Mok, Hsi-An Pan, A. E. Sansom, M. Sargent, M. W. L. Smith, Thomas G. Williams, C. Yang, Ming Zhu, Gioacchino Accurso, P. Barmby, E. Brinks, N. Bourne, Toby Brown, Aeree Chung, Eun Jung Chung, A. Cibinel, K. E. K. Coppin, Jonathan S. Davies, Timothy A. Davis, Steve Eales, Lapo Fanciullo, Taotao Fang, Yu Gao, David H W Glass, H. L. Gomez, T. R. Greve, Jinhua He, Luis C. Ho, Feng Huang, Hyunjin Jeong, Xue-Jian Jiang, Qian Jiao, F. Kemper, Ji Hoon Kim, Minjin Kim, Taehyun Kim, Jongwan Ko, Xu Kong, Kevin Lacaille, C. G. Lacey, Bumhyun Lee, Joon Hyeop Lee, Wing-Kit Lee, Karen L. Masters, Se-Heon Oh, P. P. Papadopoulos, Changbom Park, Sung‐Joon Park, Harriet Parsons, Kate Rowlands, Peter Scicluna, Jillian M. Scudder, Ramya Sethuram, S. Serjeant, Yali Shao, Yun‐Kyeong Sheen, Yong Shi, Hyunjin Shim, C. Smith, Kristine Spekkens, An-Li Tsai, A. Verma, S. Urquhart, Giulio Violino, S. Viti, David A. Wake, Junfeng Wang, J. G. A. Wouterloot, Yujin Yang, Kijeong Yim, Fang-Ting Yuan, Zheng Zheng,
JINGLE is a new JCMT legacy survey designed to systematically study the cold interstellar medium of galaxies in the local Universe. As part of the survey we perform 850 µm continuum measurements with SCUBA-2 for a representative sample of 193 Herschel-selected galaxies with M* > 109 M⊙, as well as integrated CO(2–1) line fluxes with RxA3m for a subset of 90 of these galaxies. The sample is selected from fields covered by the Herschel-ATLAS survey that are also targeted by the MaNGA optical integral- ...
Tópico(s): Stellar, planetary, and galactic studies
2018 - Oxford University Press | Monthly Notices of the Royal Astronomical Society
Andrew Szentgyorgyi, Daniel F. Baldwin, Stuart Barnes, Jacob L. Bean, Sagi Ben-Ami, Patricia Brennan, Jamie A. Budynkiewicz, Moo-Young Chun, Charlie Conroy, Jeffrey D. Crane, Harland W. Epps, I. N. Evans, Janet D. Evans, Jeff Foster, Anna Frebel, Thomas Gauron, Dani Guzmán, Tyson Hare, Bi-Ho Jang, Jeong-Gyun Jang, Andrés Jordán, Jihun Kim, Kang-Miin Kim, Claudia Mendes Mendes de Oliveira, Mercedes López‐Morales, K. G. McCracken, Stuart McMuldroch, Joseph B. Miller, Mark Mueller, Jae Sok Oh, Cem Onyuksel, Mark Ordway, Byeong-Gon Park, Chan Park, Sung‐Joon Park, Charles Paxson, David F. Phillips, David A. Plummer, William Podgorski, Andreas Seifahrt, Daniel P. Stark, J. E. Steiner, Alan Uomoto, Ronald L. Walsworth, Young-Sam Yu,
The GMT-Consortium Large Earth Finder (G-CLEF) will be a cross-dispersed, optical band echelle spectrograph to be delivered as the first light scientific instrument for the Giant Magellan Telescope (GMT) in 2022. G-CLEF is vacuum enclosed and fiber-fed to enable precision radial velocity (PRV) measurements, especially for the detection and characterization of low-mass exoplanets orbiting solar-type stars. The passband of G-CLEF is broad, extending from 3500Å to 9500Å. This passband provides good sensitivity ...
Tópico(s): Adaptive optics and wavefront sensing
2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Andrew Szentgyorgyi, Stuart Barnes, Jacob L. Bean, Bruce C. Bigelow, Antonin H. Bouchez, Moo‐Young Chun, Jeffrey D. Crane, Harland W. Epps, I. N. Evans, Janet D. Evans, Anna Frebel, Gábor Fűrész, Alex Glenday, Dani Guzmán, Tyson Hare, Bi-Ho Jang, Jeong-Gyun Jang, Ueejong Jeong, Andrés Jordán, Kang-Min Kim, Ji-Hun Kim, Chih‐Hao Li, Mercedes López‐Morales, K. G. McCracken, B. A. McLeod, Mark Mueller, Jakyung Nah, Timothy Norton, Heeyoung Oh, Jae Sok Oh, Mark Ordway, Byeong-Gon Park, Chan Park, Sung‐Joon Park, David F. Phillips, David A. Plummer, William Podgorski, F. Rodler, Andreas Seifahrt, Kyung-Mo Tak, Alan Uomoto, Marcos A. van Dam, Ronald L. Walsworth, Young Sam Yu, In-Soo Yuk,
The GMT-Consortium Large Earth Finder (G-CLEF) is an optical-band echelle spectrograph that has been selected as the first light instrument for the Giant Magellan Telescope (GMT). G-CLEF is a general-purpose, high dispersion spectrograph that is fiber fed and capable of extremely precise radial velocity measurements. The G-CLEF Concept Design (CoD) was selected in Spring 2013. Since then, G-CLEF has undergone science requirements and instrument requirements reviews and will be the subject of a preliminary ...
Tópico(s): Stellar, planetary, and galactic studies
2014 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Seongmin Park, Sung‐Joon Park, Hee‐Jin Kim, Oh‐Hyung Kwon, Tae-Wook Kang, Hyun-Ahm Sohn, Seon‐Kyu Kim, Seung Moo Noh, Kyu‐Sang Song, Se-Jin Jang, Yong Sung Kim, Seon‐Young Kim,
Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput RNA sequencing (RNA-seq). Several of the lincRNAs identified have been well characterized for their functions in carcinogenesis. Here we performed RNA-seq experiments comparing gastric cancer with normal tissues to find differentially expressed transcripts in intergenic ...
Tópico(s): RNA Research and Splicing
2013 - Springer Nature | Experimental & Molecular Medicine
Joo Hyun Park, Sung Joon Park, Young Ho Kim, Min‐Hyun Park,
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2013 - Springer Science+Business Media | European Archives of Oto-Rhino-Laryngology
Dal Yong Kim, Mi‐Na Kim, Sungkwon Jeon, Jaesung Lee, Hosik Park, You-In Park, Sung‐Joon Park, Jung‐Hyun Lee,
Fouling is a long-standing problem in water treatment membranes because it substantially deteriorates process efficiency. Here, we present a facile strategy for the in situ modification of polyethersulfone (PES) ultrafiltration (UF) membranes with eco-friendly antifouling materials (i.e., pyrogallol and taurine) to enhance their fouling resistance. When the PES dope solution was immersed into the nonsolvent containing pyrogallol and taurine, the phase separation and surface modification of the PES ...
Tópico(s): Graphene and Nanomaterials Applications
2023 - Elsevier BV | Journal of Membrane Science
Sang-Hee Park, Sang Hoon Kim, Sung‐Joon Park, Sungmin Ryoo, Kyoungja Woo, Jong Suk Lee, Taek-Seung Kim, Hee‐Deung Park, Hosik Park, You-In Park, Jinhan Cho, Jung‐Hyun Lee,
We report on a new technique that incorporates silver nanoparticles (AgNPs) onto polyamide (PA) thin film composite (TFC) reverse osmosis membranes via arc plasma deposition (APD) to impart antibacterial properties and simultaneously improve membrane performance. APD allows the direct deposition of AgNPs under vacuum dry condition, overcoming the drawbacks of the conventional wet-chemical methods. AgNPs (~7.6 nm in diameter) were uniformly distributed without aggregation throughout the PA selective layer ...
Tópico(s): Graphene and Nanomaterials Applications
2016 - Elsevier BV | Journal of Membrane Science
Sang-Hee Park, Young-Seon Ko, Sung‐Joon Park, Jong Suk Lee, Jinhan Cho, Kyung‐Youl Baek, Il Tae Kim, Kyoungja Woo, Jung‐Hyun Lee,
We present a new strategy to strongly and effectively immobilize silver nanoparticles (AgNPs) on polyamide thin film composite membranes to endow antibacterial activity. This method relies on the immobilization of relatively large silica particles (SiO2, ~400 nm in diameter), where AgNPs of ~30 nm in diameter are tightly and densely bound (AgNP@SiO2), on the membrane surface using cysteamine as a covalent linker. The formation of multiple Ag–S chemical bonds between a “bumpy” AgNP@SiO2 and the rough membrane ...
Tópico(s): Membrane Separation Technologies
2015 - Elsevier BV | Journal of Membrane Science
Jun‐Ook Park, Inn‐Chul Nam, Choung‐Soo Kim, Sung Joon Park, Dong‐Hyun Lee, Hyun-Bum Kim, Kyungdo Han, Young‐Hoon Joo,
Background: Descriptive epidemiologists have repeatedly reported that males are more susceptible to head and neck cancers. However, most published data are those of cross-sectional studies, and no population-based cohort study has yet been published. The aim of this study was to compare the prevalence of head and neck cancers in healthy males with females. Methods: A retrospective cohort study using the Korean National Health Insurance Service database on 9,598,085 individuals who underwent regular ...
Tópico(s): Cervical Cancer and HPV Research
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Jin‐Woo Park, Jong‐Chi Oh, Ho Jun Lee, Sung‐Joon Park, Tae-Sang Yoon, Bum Sun Kwon,
Tópico(s): Child Nutrition and Feeding Issues
2009 - Springer Science+Business Media | Dysphagia
Seoyon Yang, Jin‐Woo Park, Kyunghoon Min, Yoon Se Lee, Young Jin Song, Seong Hee Choi, Doo-Young Kim, Seung Hak Lee, Hee Seung Yang, Wonjae Cha, Ji Won Kim, Byung‐Mo Oh, Han Gil Seo, Min-Wook Kim, Hee‐Soon Woo, Sung-Jong Park, Sungju Jee, Ju Sun Oh, Ki Deok Park, Young Ju Jin, Sungjun Han, DooHan Yoo, Bo Hae Kim, Hyun Haeng Lee, Yeo Hyung Kim, Min‐Gu Kang, Eun‐Jae Chung, Bo Ryun Kim, Tae‐Woo Kim, Eun Jae Ko, Young Min Park, Hanaro Park, Min‐Su Kim, Jungirl Seok, Sun Im, Sung‐Hwa Ko, Seong Hoon Lim, Kee Wook Jung, Tae Hee Lee, Bo Young Hong, Woojeong Kim, Weon‐Sun Shin, Young Chan Lee, Sung Joon Park, Jeong Hyun Lim, Youngkook Kim, Jung Hwan Lee, Kang‐Min Ahn, Jun‐Young Paeng, Jeong Yun Park, Young Ae Song, Kyung Cheon Seo, Chang Hwan Ryu, Jae‐Keun Cho, Jee-Ho Lee, Kyoung Hyo Choi,
Dysphagia is a common clinical condition characterized by difficulty in swallowing. It is sub-classified into oropharyngeal dysphagia, which refers to problems in the mouth and pharynx, and esophageal dysphagia, which refers to problems in the esophageal body and esophagogastric junction. Dysphagia can have a significant negative impact one's physical health and quality of life as its severity increases. Therefore, proper assessment and management of dysphagia are critical for improving swallowing ...
Tópico(s): Tracheal and airway disorders
2023 - Korean Academy of Rehabilitation Medicine | Annals of Rehabilitation Medicine
Cherry Kim, Wooil Kim, Sung‐Joon Park, Young Hen Lee, Sung Ho Hwang, Hwan Seok Yong, Yu‐Whan Oh, Eun-Young Kang, Ki Yeol Lee,
Computed tomography (CT) is an important imaging modality in evaluating thoracic malignancies. The clinical utility of dual-energy spectral computed tomography (DESCT) has recently been realized. DESCT allows for virtual monoenergetic or monochromatic imaging, virtual non-contrast or unenhanced imaging, iodine concentration measurement, and effective atomic number (Zeff map). The application of information gained using this technique in the field of thoracic oncology is important, and therefore many ...
Tópico(s): Medical Imaging Techniques and Applications
2020 - Korean Society of Radiology | Korean Journal of Radiology
Sung‐Joon Park, Yookyung Koh, Hwisang Jeon, Hyunjae Kim, Yoonsun Yeo, Jaewoo Kang,
Abstract Transcription factors (TFs) regulate the gene expression of their target genes by binding to the regulatory sequences of target genes (e.g., promoters and enhancers). To fully understand gene regulatory mechanisms, it is crucial to decipher the relationships between TFs and DNA sequences. Moreover, studies such as GWAS and eQTL have verified that most disease-related variants exist in non-coding regions, and highlighted the necessity to identify such variants that cause diseases by interrupting ...
Tópico(s): Machine Learning in Bioinformatics
2020 - Nature Portfolio | Scientific Reports
Minsik Oh, Sung‐Joon Park, Sun Kim, Heejoon Chae,
Abstract Gene expressions are subtly regulated by quantifiable measures of genetic molecules such as interaction with other genes, methylation, mutations, transcription factor and histone modifications. Integrative analysis of multi-omics data can help scientists understand the condition or patient-specific gene regulation mechanisms. However, analysis of multi-omics data is challenging since it requires not only the analysis of multiple omics data sets but also mining complex relations among different ...
Tópico(s): Gene Regulatory Network Analysis
2020 - Oxford University Press | Briefings in Bioinformatics
Yifeng Deng, Fansi Jin, Xian Li, Sung Joon Park, Jae‐Hoon Chang, Dong Young Kim, Jung‐Ae Kim, Joo‐Won Nam, Hyukjae Choi, Youn Ju Lee, Hyeun Wook Chang,
Sauchinone, the biologically active lignan of Saururus chinensis, has been reported to have anti-inflammatory, antitumor, antioxidant, and hepatoprotective properties. However, little is known about the effect of sauchinone on FcεRI-mediated mast cell activation. The aim of this study was to evaluate the anti-allergic activity of sauchinone and the underlying mechanism using mouse bone marrow-derived mast cells (BMMCs) and the mast cell-mediated passive cutaneous anaphylaxis (PCA) model. Sauchinone ...
Tópico(s): Hops Chemistry and Applications
2019 - Elsevier BV | International Immunopharmacology
Luís Augusto Eijy Nagai, Sung‐Joon Park, Kenta Nakai,
Eukaryotes compact chromosomes densely and non-randomly, forming three-dimensional structures. Alterations of the chromatin structures are often associated with diseases. In particular, aggressive cancer development from the disruption of the humoral immune system presents abnormal gene regulation which is accompanied by chromatin reorganizations. How the chromatin structures orchestrate the gene expression regulation is still poorly understood. Herein, we focus on chromatin dynamics in normal and ...
Tópico(s): Lymphoma Diagnosis and Treatment
2019 - BioMed Central | BMC Medical Genomics
Wenqian Chen, Sung Joon Park, Fanlu Kong, Xiaoyu Li, Huaiyu Yang, Jerry Y. Y. Heng,
As a purification technology, crystallization is advantageous over chromatography and precipitation in terms of purity, cost, and scalability. In general, proteins have slow crystallization kinetics due to their complex configurations, but this problem can be overcome with heterogeneous nucleants. High protein-loading mesoporous silica is a promising nucleant due to its favorable interaction with protein. The current study employs such a template in the batch crystallization of lysozyme and thaumatin ...
Tópico(s): Protein purification and stability
2019 - American Chemical Society | Crystal Growth & Design
Soichiro Yamanaka, Hidenori Nishihara, Hidehiro Toh, Luís Augusto Eijy Nagai, Kosuke Hashimoto, Sung‐Joon Park, Aoi Shibuya, Ana Maria Suzuki, Yujiro Tanaka, Kenta Nakai, Piero Carninci, Hiroyuki Sasaki, Haruhiko Siomi,
Highlights•Chromosomes in gonocytes contain differentially accessible domains (DADs)•Young LINE-1 elements in DADs become activated in the middle of the gonocyte stage•DADs are resistant to the first wave of de novo DNA methylation•3D chromosome organization is reprogrammed in gonocytesSummaryFacultative heterochromatin forms and reorganizes in response to external stimuli. However, how the initial establishment of such a chromatin state is regulated in cell-cycle-arrested cells remains unexplored. ...
Tópico(s): Genomics and Chromatin Dynamics
2019 - Elsevier BV | Developmental Cell
Dong‐Han Lee, Sang-Youp Lee, Minhyung Lee, Jungirl Seok, Sung Joon Park, Young Ju Jin, Doh Young Lee, Tack‐Kyun Kwon,
Importance Permanent surgical treatment for unilateral vocal fold paralysis (UVFP) should be performed when further neural recovery is improbable. Conservative delay of the surgical procedure may cause unnecessary deterioration of the patient's quality of life. Knowledge of the natural course of UVFP is important for better management and counseling. Objective To evaluate the natural course of UVFP, focusing on the recovery time according to the injury level to assess the optimal timing for permanent surgical ...
Tópico(s): Nerve Injury and Rehabilitation
2019 - American Medical Association | JAMA Otolaryngology–Head & Neck Surgery
Sung‐Joon Park, Satoru Onizuka, Masahide Seki, Yutaka Suzuki, Takanori Iwata, Kenta Nakai,
Microbial contamination poses a major difficulty for successful data analysis in biological and biomedical research. Computational approaches utilizing next-generation sequencing (NGS) data offer promising diagnostics to assess the presence of contaminants. However, as host cells are often contaminated by multiple microorganisms, these approaches require careful attention to intra- and interspecies sequence similarities, which have not yet been fully addressed.We present a computational approach ...
Tópico(s): Genomics and Phylogenetic Studies
2019 - BioMed Central | BMC Biology
Sang‐Yeon Lee, Seul-Ki Song, Sung Joon Park, Han Gyeol Park, Byung Yoon Choi, Ja‐Won Koo, Jae‐Jin Song,
To discuss the possible pathophysiologic mechanism of pulsatile tinnitus (PT) perception due to high jugular bulb with bony dehiscence (HJBD) and its improvement after the dehiscent jugular bulb (JB) resurfacing using bone cement, and to describe the efficacy of an objective measure of PT using transcanal sound recording and spectro-temporal analysis (TSR/STA).Retrospective case series study.A university-based, tertiary care cancer center.Three PT patients with HJBD.All patients underwent transtympanic ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2019 - Lippincott Williams & Wilkins | Otology & Neurotology
Tzuu‐Huei Ueng, Y UENG, Jih‐Jin Tsai, I.-C. Chao, Tai‐Lin Chen, Sung‐Joon Park, M. Iwasaki, F. Peter Guengerich,
The effects of ethanol on hamster hepatic and extrahepatic monooxygenases were determined in the present study. Chronic ethanol administration increased cytochrome P-450 (P-450) content and monooxygenase activities towards aniline, N-nitrosodimethylamine, and 7-ethoxyresorufin. In contrast, benzphetamine and benzo(a)pyrene oxidation rates were decreased 21–24% by ethanol. In kidney, ethanol pretreatment increased P-450 content, aniline and N-nitrosodimethylamine oxidation activities. In lung, ethanol ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
1993 - Elsevier BV | Toxicology
Sung‐Joon Park, Soon Jin Kwon, Hyo-Eun Kwon, Min Gyu Shin, Sang-Hee Park, Hosik Park, You-In Park, Seung‐Eun Nam, Jung‐Hyun Lee,
We report an aromatic solvent-assisted interfacial polymerization (IP) method to prepare high performance thin film composite reverse osmosis (RO) membranes based on a polyacrylonitrile support. The use of toluene and xylene as an organic solvent phase led to excellent water flux and unprecedentedly high NaCl rejection (∼99.9%), exceeding both the control membrane prepared using a conventional aliphatic solvent (n-hexane) and commercial RO membranes. The membrane prepared using n-hexane had a thick and ...
Tópico(s): Fuel Cells and Related Materials
2018 - Elsevier BV | Polymer
Myung‐Yeon Cho, Sung‐Joon Park, So-Mang Kim, Dong‐Won Lee, Hongki Kim, Sang‐Mo Koo, Kyoung-Sook Moon, Jong‐Min Oh,
Tópico(s): Aerosol Filtration and Electrostatic Precipitation
2018 - Elsevier BV | Ceramics International
Minji Jeon, Sunkyu Kim, Sung‐Joon Park, Heewon Lee, Jaewoo Kang,
Drug combination therapy, which is considered as an alternative to single drug therapy, can potentially reduce resistance and toxicity, and have synergistic efficacy. As drug combination therapies are widely used in the clinic for hypertension, asthma, and AIDS, they have also been proposed for the treatment of cancer. However, it is difficult to select and experimentally evaluate effective combinations because not only is the number of cancer drug combinations extremely large but also the effectiveness ...
Tópico(s): vaccines and immunoinformatics approaches
2018 - Springer Science+Business Media | BMC Systems Biology
Hyo-Eun Kwon, Soon Jin Kwon, Sung‐Joon Park, Min Gyu Shin, Sang-Hee Park, Min Sang Park, Hosik Park, Jung‐Hyun Lee,
A high performance thin film composite (TFC) forward osmosis (FO) membrane was prepared using a hydrophilic polyacrylonitrile (PAN) support with a tailored structure via a newly devised, aromatic solvent (toluene)-based interfacial polymerization (TIP) technique. The use of toluene as the organic solvent promoted amine diffusion toward the organic phase and the subsequent reaction, leading to the formation of an ultrathin (highly permeable) and highly dense (highly selective) polyamide selective layer ...
Tópico(s): Membrane-based Ion Separation Techniques
2018 - Elsevier BV | Separation and Purification Technology
Sung‐Joon Park, Jung Min Kim, Won‐Ho Shin, Sung Won Han, Minji Jeon, Hyun Jin Jang, Ik‐Soon Jang, Jaewoo Kang,
Identifying gene regulatory networks is an important task for understanding biological systems. Time-course measurement data became a valuable resource for inferring gene regulatory networks. Various methods have been presented for reconstructing the networks from time-course measurement data. However, existing methods have been validated on only a limited number of benchmark datasets, and rarely verified on real biological systems. We first integrated benchmark time-course gene expression datasets ...
Tópico(s): Bioinformatics and Genomic Networks
2018 - Springer Science+Business Media | BMC Systems Biology
Sung Joon Park, Sungjun Han, Hyo‐Jung Lee, Soon‐Hyun Ahn, Woo‐Jin Jeong,
This study evaluated salivary function after extracapsular dissection (ECD) compared with partial superficial parotidectomy (PSP) and classic superficial parotidectomy (CSP) of benign parotid gland tumors. The authors hypothesized that ECD would be superior to PSP and CSP in preserving postoperative salivary function.Retrospective analyses were performed for 43 consecutive patients who underwent parotidectomies of benign parotid tumors performed by a single experienced surgeon. Clinical data and pre- ...
Tópico(s): Ear and Head Tumors
2018 - Elsevier BV | Journal of Oral and Maxillofacial Surgery