Gráinne Gilmore, Andrew Robson, Christina Hardyment, Ramita Naval, S. R. E. Fletcher, Edward Owen, Richard Whitehead, Matthew Syed, Bel Mooney, Andrew Pierce, Bruce Houlder, Adam Sherwin Media Reporter, Greg Hurst Political Correspondent, Dr Thomas Stuttaford and Suzi Godson, Simon Barnes, Chris Tarrant, Michael Owen, Paul Hoggart, Gavin Copeland, Richard Hobson, Nigel Hawkes and Tom Hirst, Justine Hardy, Nick Hawton, Ivo Tennant, Clare Lazaro, Michael Evans Defence Editor, Philip Howard, Carol Midgley, David Chater, Zoe Strimpel, James Harkin, Anthony Horowitz, James Bone, Brian Pedley, Michael Dnes, Nic Hopkins, Henry Porter, Clive Davis, Elizabeth Judge, Richard Irving, Lucia Van Der Post, Patrick Kidd, Sam Marlowe, Michelle Henrey, Geoff Brown, Sam Lister, E Jane Dickson, Giles Coren, Andrew Norfolk, Vivienne Parry, Caroline Hendrie, Michael Oakley, Jim Hendrix, Pat Gibson, Nancy Durrant, John Clarke, Simon Beckett John Angerson, Gerard Rosenberg, Valerie Elliott, Robert Gore-Langton, Lizzle Francke, Dominic Walsh, Tom Bawden, James Doran Wall Street Correspondent, Don touhig, Debra Craine, Gary Jacob, Rob Penn, Richard Wilson, Allan Simmons, Joseph Kanon, Dr Jane Collins, Tim Reid, Angela Jameson Industrial Correspondent, Dan Sabbagh, Sarah Thomas, Natalie Press, MM, Richard Ford Home Correspondent, Jo Morris, Stephen Farrell, Peter Millar, Robert Ashmead, Alice Peterson, Nickel Creek, Nick Wyke, Rhys Blakely, Gustave Flaubort, Martin Symington, Helen Rumbelow, Matt Dickinson Chief Football Correspondent, Stefanie Marsh, Jonathan Sacks, Mark Ogden, Nell Johnston, Tim Teeman, Caroline Merrell Banking Correspondent, Derwent May, Rose Gray Ruth Rogers, Angela Jameson, Patricia Ward, Dr George Lewith, Paula Hawkins, Daniel McGrory and Sean O'Neill, Liam Gallagher, Keith Hopcroft, Gp, Daniel McGrory, Ed Potton, Carola Long, Gerard Baker, Leonard Scott, Katie Hickman, Stephen Anderton, Mark Atherton, Lisa Armstrong, John Westerby, Angus Donald, Patricia Highsmith, Mark Henderson Science Correspondent, David Lawrenson, Wendy Moore, Tom Perrotta, Jane Knight Deputy Travel Editor, David Baddiel, Neel Mukherjee, Laura Lee Davies, Rob Wright, Geoffrey Dean, Christina Koning, Caitlin Moran and Pete Paphides, David Powell Athletics Correspondent, Raymond Keene, Antonia Senior Deputy Personal Finance Editor, Bernard Wood, Steve Bird and Richard Ford, Lewis Smith, Matthew Pryor, John Russell Taylor, Rebecca O'Connor, Gordon Ramsay, Adam Fresco and Ben Hoyle, Christine Buckley Industrial Editor, Benji Wilson, Sean O'Neill, David Orr, Kaveh Solhekol, Xan Rice, Roger Davies, Jeremy Page, Caroline Merrell, Neville Scott, Janine Di Giovanni, Rick Jones, Helen Nugent, Richard Owen, Shane Warne, Dave Griffiths, Christopher Martin-Jenkins Chief Cricket Correspondent, Ross Leckie, Richard Crowhurst, B. A. Vickers, Erica Wagner, David Lodge, Tom Hirst, John Jose, Gabriel Rozenberg Economics Reporter, Chloë Bryan-Brown, Tim Vine, Graham Searjeant Personal Investor, Tom Dart, Julian Muscat, Paul Simons, Anna Frame, Rosemary Bennett and Richard Ford, Nigel Kendall, Nick Szczepanik, Dominic Kennedy, Heather McGREGOR, Jane Macquitty, Giles Whittell, Tom Cox, Robert Crampton, Jane Shilling, Michael BINYON, Julie Burchill, Dominic Maxwell, Matthew Parris, Peter Donaldson, Amanda Craig, George Caulkin, Jonathan Rendall, Russell Jenkins, Rebecca Ley, Michael Austin, Celia Dodd, John Sloboda, Helen Pridham, Richard Beeston Diplomatic Editor, Jack Malvern Arts Reporter, Jacqui Goddard, John Naish, Richard Gwyn, Kieran Falconer, Catherine Philp, Martin Waller, Ruth Hedges, Martin Penton, Mark Baldwin, Sarah Butler, Anna Shepard, Darian Leader, Laura Fumiko Keehn, Vivian Cook, Dr Thomas Stuttaford, Jill Crawshaw, Stephen Dalton, Philip Booth, Simon Walton, Ben Hoyle, Leo Lewis, David Powell, Alyson Rudd, Tom Chesshyre, Richard Morrison, James Christopher, Michael Henderson, Alan Jackson, Owen Slot, Olav Bjortomt, Jenny Davey, Edward Gorman Sailing Correspondent, Mike Tyson, Eleanor Updale, Jane Macartney, Patience Wheatcroft, Nick Meo, Joe Bolger, Christopher Irvine, Irma Kurtz,
... about the the Victorian kitchen garden Josefina de Vasconcellos Sculptor who created powerful religious images—and also ...
2005 - Gale Group | TDA
Produção Nacional
Revisado por pares
Carlos Frederico Vasconcellos, Patrícia Nunes da Silva,
We study the stabilization of global solutions of the Kawahara (K) equation in a bounded interval, under the effect of a localized damping mechanism. The Kawahara equation is a model for small amplitude long waves. Using multiplier techniques and compactness arguments we prove the exponential decay of the solutions of the (K) model. The proof requires of a unique continuation theorem and the smoothing effect of the (K) equation on the real line, which are proved in this work.
Tópico(s): Navier-Stokes equation solutions
2009 - EDP Sciences | ESAIM Control Optimisation and Calculus of Variations
Roger Bannister, J. J. R. Trethowan, E. Colston Shepherd The Sunday Times Air Correspondent, Richard Buckle, Clarence Elliott, C. L. Beate, Gerald Delany Representative of The Sunday Times, Stephen Coulter Representative of The Sunday Times, Elizabeth Nicholas, Harold Hobson, Ian Peebles, Janice Elliott, James Margach Political Correspondent of The Sunday Times, J. D. Scott, Nicholas Carroll The Sunday Times Diplomatic Correspondent, J. W. Lambert, J. D. Casswell, Rosalind Wilkinson, A. E. B. Plummer, Julian Symons, Richard Kellett, Hailsham, Prof. Yuri Demetriev of the Soviet Academy of Sciences, Henry Brandon, William Wordsworth, Evelyn Irons The Sunday Times Representative, John Russell, Elizabeth David, James Margach The Sunday Times Political Correspondent, Robert Targett Representative of The Sunday Times, Jerome P. Webster, Hugh Wynn, Arthur Jenkins, Mat. C Byrne, Vivian Jenkins, Rt. Hon. Harold Wilson M. P., Stephen Watts, Sidney Salomon, Bishop Wand, S G Lendon, Antony Terry The Sunday Times Representative, D R Gent, Rev. Dr. W. E. Sangster, Cyril Connolly, E. G., Sir Herbert Thompson, James Watts, Richard Hughes Representative of The Sunday Times, Raymond Mortimer, Robert Blake, John Ivey, Arthur Wade, A. B. Ramsay, Patricia Cooke, A. MacC Armstrong, Henry Brandon Representative of The Sunday Times, Susan Noel, Roger Mortimer, Ronald Hingley, Ernestine Carter, Mr. Ernest Marples Minister of Transport, M. Pikesley, Mr. Arthur Dickson Wright, Peter Collins Science Correspondent of The Sunday Times, Desmond Shawe-Taylor, Angela Banfield, Bernard Hollowood Editor of "Punch", R. L. Hollands, Mrs. Stella A. Walker, R. C. Robertson-Glasgow, Dilys Powell, Shena D Simon, William Shepherd M. P, Felix Aprahamian, G de la Condamine, Robert Robinson, Henry Longhurst, Frank Allaun, Peter Collins, G. F. Casartelli, Brian Glanville, Iain Lang, C. H. O'd. Alexander, George Schwartz, Maurice Wiggin, Noel Stevenson Programme Administration Officer, Robert Harling, C. G. Varty, Kenneth Konstam, Henry Thody Representative of The Sunday Times, Peter Garnier Sports Editor of "The Autocar",
... to Iraq In her Wimbledon studio Josephina de Vasconcellos… BEA Comet Makes First Moscow Call By Our ...
1959 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Carlos Frederico Vasconcellos, Patrícia Nunes da Silva,
We study the stabilization of global solutions of the linear Kawahara (K) equation in a bounded interval under the effect of a localized damping mechanism. The Kawahara equation is a model for small amplitude long waves. Using multiplier techniques a
Tópico(s): Nonlinear Photonic Systems
2008 - IOS Press | Asymptotic Analysis
C. G. Thanos, Riccardo Calafiore, Giuseppe Basta, Briannan Bintz, W.J. Bell, Jebecka Hudak, Alfred V. Vasconcellos, Patricia Schneider, S.J.M. Skinner, Marilyn S. Geaney, P. L. J. Tan, Robert Elliot, Michele A. Tatnell, Lina M. Escobar, Hui Qian, Edith Mathiowitz, Dwaine F. Emerich,
Abstract Alginate encapsulation is one of the most widely used techniques for introducing cell‐based therapeutics into the body. Numerous encapsulation methodologies exist, utilizing a variety of alginates, purification technologies, and unique polycationic membrane components. The stability of a conventional alginate formulation encapsulated using a commercially available technique and apparatus has been characterized extensively. The current study employs an encapsulation protocol and ultra‐pure ...
Tópico(s): Pancreatic function and diabetes
2007 - Wiley | Journal of Biomedical Materials Research Part A
Produção Nacional
Revisado por pares
Mônica L. Vieira, Lina Paola D’Atri, Mirta Schattner, Alejandra Habarta, Angela Silva Barbosa, Zenáide Maria de Morais, Sílvio Arruda Vasconcellos, Patrícia Antônia Estima Abreu, Ricardo M. GÃ mez, Ana L. T. O. Nascimento,
It has been reported previously that activation of vascular endothelium by outer membrane proteins of the spirochetes Borrelia sp. and Treponema sp. resulted in enhanced expression of endothelial cell adhesion molecules. To investigate the role of leptospiral proteins in this process, a predicted lipoprotein encoded by the gene LIC10365 was selected, which belongs to a paralogous family that presents a domain of unknown function, DUF1565. The LIC10365 gene was cloned and the protein expressed in ...
Tópico(s): Leptospirosis research and findings
2007 - Oxford University Press | FEMS Microbiology Letters
Produção Nacional
Revisado por pares
Leonardo Henrique Ferreira Gomes, Thomas D. Otto, Érico A. Vasconcellos, Patrícia Mello Ferrão, Renata Martins Maia, Aline dos Santos Moreira, Marcelo Alves Ferreira, L.R.R. Castello-Branco, Wim Degrave, Leila Mendonça-Lima,
ABSTRACT Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine available against tuberculosis, and the strains used worldwide represent a family of daughter strains with distinct genotypic characteristics. Here we report the complete genome sequence of M. bovis BCG Moreau, the strain in continuous use in Brazil for vaccine production since the 1920s.
Tópico(s): Immunodeficiency and Autoimmune Disorders
2011 - American Society for Microbiology | Journal of Bacteriology
Produção Nacional
Revisado por pares
Hito Braga de Moraes, J.M. Vasconcellos, Patrícia Maria Campos de Almeida,
Tópico(s): Spacecraft and Cryogenic Technologies
2006 - Elsevier BV | Ocean Engineering
Produção Nacional
Revisado por pares
Júlia Ribeiro Lemos, Felipe A. Cunha, Agnaldo José Lopes, Fernando Silva Guimarães, Fabrício Vasconcellos, Patrícia dos Santos Vigário,
BACKGROUND: Respiratory muscle training (RMT) has been recommended to mitigate impacts of spinal cord injuries (SCI), but the optimal dosage in terms of the frequency, intensity, time, and type (FITT principle) to promote health in SCI individuals remains unclear. OBJECTIVE: To discuss research rel ated to the effects of RMT on pulmonary function, respiratory muscle strength and cardiorespiratory fitness in athletes and non-athletes with SCI, presenting the FITT principle. METHODS: We performed a systematic ...
Tópico(s): Respiratory Support and Mechanisms
2019 - IOS Press | Journal of Back and Musculoskeletal Rehabilitation
Produção Nacional
Revisado por pares
Fabiana Lauretti-Ferreira, Paloma L. D. Silva, Naiara M. Alcântara, Bruna Fernanda da Silva, Isabele Grabher, Gisele Oliveira de Souza, Erika Nakajima, Milena Apetito Akamatsu, Sílvio Arruda Vasconcellos, Patrícia Antônia Estima Abreu, Enéas Carvalho, Elizabeth A. L. Martins, Paulo Lee Ho, Josefa B. da Silva,
Pathogenic spirochetes from genus Leptospira are etiologic agents of leptospirosis. Cellular vaccines against Leptospira infection often elicit mainly response against the LPS antigen of the serovars present in the formulation. There is no suitable protein candidate capable of replacing whole-cell vaccines, thus requiring new approaches on vaccine development to improve leptospirosis prevention. Our goal was to develop a whole-cell vaccine sorovar-independent based on LPS removal and conservation ...
Tópico(s): Veterinary medicine and infectious diseases
2020 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Bruno Guimarães Marinho, Leandro S. M. Miranda, Niele M. Gomes, Maria Eline Matheus, Suzana Guimarães Leitão, Mário L. A. A. Vasconcellos, Patrícia Dias Fernandes,
The objective of this study was to investigate spinal and supraspinal antinociceptive effects of a new synthetic compound, (±)-cis-(6-ethyl-tetrahydropyran-2-yl)-formic acid (tetrahydropyran derivative). Its activity was compared with those from morphine. In peripheral models of inflammation and hyperalgesia, tetrahydropyran derivative significantly reduced nociceptive effect induced by acetic acid or formalin in mice. Tetrahydropyran derivative developed antinociceptive effect on the tail-flick and ...
Tópico(s): Asymmetric Synthesis and Catalysis
2006 - Elsevier BV | European Journal of Pharmacology
Bernd H. A. Rehm, Regina Vasconcellos António, Patricia Spiekermann, Amro Abd Al Fattah Amara, Alexander Steinbüchel,
A threading model of the Ralstonia eutropha polyhydroxyalkanoate (PHA) synthase was developed based on the homology to the Burkholderia glumae lipase, whose structure has been resolved by X-ray analysis. The lid-like structure in the model was discussed. In this study, various R. eutropha PHA synthase mutants were generated employing random as well as site-specific mutagenesis. Four permissive mutants (double and triple mutations) were obtained from single gene shuffling, which showed reduced activity ...
Tópico(s): Biofuel production and bioconversion
2002 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Produção Nacional
Revisado por pares
Vera Maria Ramos de Vasconcellos, Anne Patrícia Pimentel Nascimento da Silva, Roberta Teixeira De Souza,
O artigo inicia com uma discussão teórica do que são as revisões críticas dos modos de produção no campo da Educação reconhecidos como “Estado da Arte” e “Estado do Conhecimento”. São estudos que sistematizam o que foi produzido durante um período de tempo e área de abrangência, observando rastros deixados no percurso histórico de suas produções. Esses termos são comumente utilizados como sinônimos em variadas investigações, apesar das diferenças existentes. Na segunda parte é apresentado um balanço ...
Tópico(s): Academic Research in Diverse Fields
2020 - Editora da Pontifícia Universidade Católica do Rio Grande do Sul (EDIPUCRS) | Educação
Produção Nacional
Clarissa Vasconcellos Soares, Patrícia Martins Pinto,
Objetivo: Analisar, identificar e refletir sobre o controle da dor através dos cuidados paliativos, principais dificuldades enfrentadas e importância no período neonatal. Revisão bibliográfica: Cuidados paliativos têm como princípio proporcionar acolhimento aos pacientes e familiares e assegurar a melhora da qualidade de vida, na intervenção da dor, especialmente no período neonatal, ciclo que detém alta fragilidade infantil. Na neonatologia, episódios de dor ainda possuem repletos tabus e mitos, ...
Tópico(s): Infant Development and Preterm Care
2023 - | Revista Eletrônica Acervo Médico
Produção Nacional
Revisado por pares
Sílvio José Lemos Vasconcellos, Patrícia Picon, Laura Pithan Prochnow, Gabriel José Chittó Gauer,
Este artigo tem por objetivo revisar a literatura internacional publicada no período de 1980 até 2004 sobre o Modelo de Processamento das Informações Sociais, utilizando as palavras-chave cognição social e processamento de informações sociais (PsycINFO). Os autores analisam a convergência desses estudos quanto ao processamento das informações sociais por crianças e adolescentes agressivos. De acordo com o modelo, a resposta comportamental de uma criança ou adolescente para um estímulo social problemático ...
Tópico(s): Child Development and Digital Technology
2006 - UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE | Estudos de Psicologia (Natal)
Produção Nacional
Revisado por pares
Carolina Giordani da Silva, Edwing Alberto Urrea Vega, Fernanda Peixoto Córdova, Flávia Aline Carneiro, Karina de Oliveira Azzolin, Lucas Henrique de Rosso, Murilo dos Santos Graeff, Patrícia Vasconcellos de Carvalho, Míriam de Abreu Almeida,
ABSTRACT Objective: To describe the use of the Systematized Nomenclature of Medicine - Clinical Terms (SNOMED-CT) as a model for interoperability of the nursing terminology in the national and international contexts. Methods: This is an integrative literature review according to Cooper, which searched for articles in Portuguese, English and Spanish, published between September 2011 and November 2018 in the BVS, PubMed, SCOPUS, CINAHL, EMBASE, and Web of Science databases, ending in a sample of 15 articles. ...
Tópico(s): linguistics and terminology studies
2020 - UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL | Revista gaúcha de enfermagem
Produção Nacional
Revisado por pares
Ana Paula Porto Noronha, Camila Rafaela Baldo, Marília Cristina de Almeida, Joseane Vasconcellos de Freitas, Patrícia Fagnani Barbin, Juliana Cozoli,
O objeto de estudo do presente trabalho é a formação em avaliação psicológica. O ensino de avaliação tem sido considerado um problema central na formação em psicologia, tendo-se em vista que diferentes autores têm apontado para uma relação entre atuações profissionais impróprias e formação inconsistente na área. O trabalho tem como objetivo analisar o conhecimento que estudantes de psicologia e de engenharia têm a respeito de conteúdos relativos à avaliação psicológica. Participaram 193 sujeitos, ...
Tópico(s): Education Pedagogy and Practices
2004 - UNIVERSIDADE ESTADUAL DE MARINGÁ | Psicologia em Estudo
Produção Nacional
Rodrigo MarcelValentimdaSilva,
... Thamara Raquel Santos de Oliveira , Liliane Santos de Vasconcellos , Patricia Froes Meyer , Yuri Alexander Afonso , Ciro Dantas Soares , ...
Tópico(s): Body Contouring and Surgery
2019 - | International Journal of Advanced Research
Bernd H. A. Rehm, Regina Vasconcellos António, Patricia Spiekermann, Amro Abd Al Fattah Amara, Alexander Steinbüchel,
Tópico(s): Biofuel production and bioconversion
2002 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Produção Nacional
Revisado por pares
Giovanna C. Guimarães, Paulo Farinatti, Adrian W. Midgley, Fabrício Vasconcellos, Patrícia dos Santos Vigário, Felipe A. Cunha,
Guimarães, GC, Farinatti, PTV, Midgley, AW, Vasconcellos, F, Vigário, P, and Cunha, FA. Relationship between percentages of heart rate reserve and oxygen uptake reserve during cycling and running: a validation study. J Strength Cond Res 33(7): 1954-1962, 2019-This study investigated the relationship between percentages of heart rate reserve (%HRR) and oxygen uptake reserve (%VO2R) during a cardiopulmonary exercise test (CPET) and discrete bouts of isocaloric cycling and treadmill running. Thirty men ...
Tópico(s): Sports Performance and Training
2017 - Lippincott Williams & Wilkins | The Journal of Strength and Conditioning Research
Produção Nacional
Ana Claúdia Celestino Bezerra Leite, Raquel de Vasconcellos Carvalhães de Oliveira, Patrícia Moura, Célia Maria Silva, Clarisse Lobo,
Background: Stroke is a potentially fatal complication of sickle cell disease in children between 2-16 years and transcranial Döppler has been recommended as a screening method in these cases. Objective:The main goal of this study was to correlate transcranial Döppler results to complications related to stroke in sickle cell disease and baseline characteristics of the population. Methods:This was an observational study of children and adolescents with ages between 2-16 years with sickle cell disease ...
Tópico(s): Autopsy Techniques and Outcomes
2012 - Elsevier BV | Revista Brasileira de Hematologia e Hemoterapia
Produção Nacional
Revisado por pares
Danielly Gonçalves Wolff, Mónica Marcela Castiblanco-Valencia, Cecília M. Abe, Denize Monaris, Zenáide Maria de Morais, Gisele Oliveira de Souza, Sílvio Arruda Vasconcellos, Lourdes Isaac, Patrícia Antônia Estima Abreu, Angela Silva Barbosa,
The elongation factor Tu (EF-Tu), an abundant bacterial protein involved in protein synthesis, has been shown to display moonlighting activities. Known to perform more than one function at different times or in different places, it is found in several subcellular locations in a single organism, and may serve as a virulence factor in a range of important human pathogens. Here we demonstrate that Leptospira EF-Tu is surface-exposed and performs additional roles as a cell-surface receptor for host plasma ...
Tópico(s): Viral Infections and Vectors
2013 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Aline Guio Cavaca, Paulo Roberto Vasconcellos-Silva, Patrícia Ferreira, João Arriscado Nunes,
The scope of this study is to conduct an assessment of the media coverage and dissemination of health issues in Portugal in order to problematize the aspects of coverage and invisibility of health topics and establish the themes neglected in media coverage. To achieve this, the coverage on health issues in the Portuguese daily newspaper Público was compared with the epidemiological context regarding health priorities and the perceptions of key players on media dissemination and the themes that are ...
Tópico(s): Global Public Health Policies and Epidemiology
2015 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Carlos Frederico Vasconcellos, Patrícia Nunes da Silva,
Tópico(s): Nonlinear Photonic Systems
2010 - IOS Press | Asymptotic Analysis
Produção Nacional
Revisado por pares
Maria Teresa Junqueira Garcia, Fabia Leal Lopes de Vasconcellos, Chloe Patricia Raffier, Michael S. Roberts, Jeffrey E. Grice, Heather A. E. Benson, Vânia Rodrigues Leite‐Silva,
It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2018 - Bentham Science Publishers | Current Topics in Medicinal Chemistry
Produção Nacional
Revisado por pares
Lucas de Souza Falcão, Isabella de Lima Oliveira, Raiana Silveira Gurgel, Antônio Fabio Lopes de Souza, Leilane Bentes de Sousa, E. O. Usuda, Thaís Santiago do Amaral, Priscilla C. Veggi, Pedro Henrique Campelo, Marne Carvalho de Vasconcellos, Patrícia Melchionna Albuquerque, Mariana Agostini de Moraes,
Drug-release systems have attracted attention over the last few years since they can be used as a substitute for traditional methods of drug delivery. These have the advantage of being directly administered at the treatment site and can maintain the drug at adequate levels for a longer period, thus increasing their efficacy. Starch-based films are interesting candidates for use as matrices for drug release, especially due to starch's non-toxic properties and its biocompatibility. Endophytic fungi ...
Tópico(s): Chemical synthesis and alkaloids
2023 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Bruno Guimarães Marinho, Leandro S. M. Miranda, Jerônimo da Silva Costa, Suzana Guimarães Leitão, Mário L. A. A. Vasconcellos, Vera L. P. Pereira, Patrícia Dias Fernandes,
The compound (±)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one [(±)-δ-lactone] was isolated from the plant Vitex cymosa Bertero, and determined to be the active principle. The present study aimed to evaluate the antinociceptive effect of (±)-δ-lactone and to elucidate its mechanism of action. Mice were subjected to in-vivo models of acute pain (acetic acid-induced abdominal writhing, formalin and hot-plate tests) and the open-field test. (±)-δ-Lactone, administered orally (6-900 µmol/kg), exerted a dose-dependent ...
Tópico(s): Phytochemistry and Biological Activities
2012 - Lippincott Williams & Wilkins | Behavioural Pharmacology
Produção Nacional
Revisado por pares
Paulo Ricardo Criado, Roberta Fachini Jardim Criado, Cídia Vasconcellos, José Roberto Pereira Pegas, Patrícia Calil,
Abstract Drug‐induced hypersensitivity syndrome (DIHS) usually refers to severe cutaneous drug eruption associated with systemic involvement and potentially fatal outcome. We report a 2‐year‐old Caucasian boy who developed DIHS due to phenytoin and phenobarbital and who showed extensive internal organ involvement. We are alerting that failure to recognize this drug eruption and discontinue the culprit drug may result in increased severity, greater extent of internal organ involvement, and fatal outcome. ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2004 - Wiley | The Journal of Dermatology
Produção Nacional
Revisado por pares
Denize Monaris, Maria E. Sbrogio-Almeida, Cristina Corsi Dib, Tatiane Canhamero, Gisele Oliveira de Souza, Sílvio Arruda Vasconcellos, Luís Carlos de Souza Ferreira, Patrícia Antônia Estima Abreu,
Leptospirosis is a global zoonotic disease caused by different Leptospira species, such as Leptospira interrogans, that colonize the renal tubules of wild and domestic animals. Thus far, attempts to develop effective leptospirosis vaccines, both for humans and animals, have failed to induce immune responses capable of conferring protection and simultaneously preventing renal colonization. In this study, we evaluated the protective immunity induced by subunit vaccines containing seven different recombinant ...
Tópico(s): Veterinary medicine and infectious diseases
2015 - American Society for Microbiology | Clinical and Vaccine Immunology
Produção Nacional
Revisado por pares
Mariana Achad, Sofía Caumo, Pérola de Castro Vasconcellos, Héctor Bajano, Darío Gómez, Patricia Smichowski,
A study concerning the identification and quantification of key chemical markers of biomass burning namely, levoglucosan and potassium in size-fractionated airborne particulate matter was conducted. To perform a complete characterization of PM2.5 and PM10 samples collected in Buenos Aires, Argentina black carbon, metals and metalloids were also determined. Due to the particularly complex chemical composition of atmospheric aerosols several analytical techniques were employed. Levoglucosan was extracted ...
Tópico(s): Odor and Emission Control Technologies
2018 - Elsevier BV | Microchemical Journal