Sumithira Vasu, Shun He, Carolyn Cheney, Bhavani Gopalakrishnan, Rajeswaran Mani, Gerard Lozanski, Xiaokui Mo, Veronica Groh, Susan P. Whitman, Renate Konopitzky, Christian Kössl, Donna Bucci, David Lucas, Jianhua Yu, Michael A. Caligiuri, William Blum, Paul J. Adam, Eric Borges, Bjoern Rueter, Karl‐Heinz Heider, Guido Marcucci, Natarajan Muthusamy,
Key Points BI 836858, an Fc-engineered anti-CD33 antibody, mediates autologous and allogeneic NK cell–mediated ADCC. Decitabine increases ligands for activating NK receptors potentiating BI 836858 activity, providing a rationale for combination therapy.
Tópico(s): T-cell and B-cell Immunology
2016 - Elsevier BV | Blood
Stephanie P. B. Caligiuri, Paul J. Kenny,
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2017 - Springer Nature | Neuropsychopharmacology
Imo E. Hoefer, Sabine Steffens, Mika Ala‐Korpela, Magnus Bäck, Lina Badimón, Marie‐Luce Bochaton‐Piallat, Chantal M. Boulanger, Giuseppina Caligiuri, Stefanie Dimmeler, Jesús Egido, Paul C. Evans, Tomasz J. Guzik, Brenda R. Kwak, Ulf Landmesser, Manuel Mayr, Claudia Monaco, Gerard Pasterkamp, José Tuñón, Christian Weber,
Identification of subjects at increased risk for cardiovascular events plays a central role in the worldwide efforts to improve prevention, prediction, diagnosis, and prognosis of cardiovascular disease and to decrease the related costs. Despite their high predictive value on population level, traditional risk factors fail to fully predict individual risk. This position paper provides a summary of current vascular biomarkers other than the traditional risk factors with a special focus on the emerging − ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2015 - Oxford University Press | European Heart Journal
Zejuan Li, Tobias Herold, Chunjiang He, Peter J.M. Valk, Ping Chen, Vindi Jurinović, Ulrich Mansmann, Michael D. Radmacher, Kati Maharry, Miao Sun, Xinan Yang, Hao Huang, Xi Jiang, Maria-Cristina Sauerland, Thomas Büchner, Wolfgang Hiddemann, Abdel Elkahloun, Mary Beth Neilly, Yanming Zhang, Richard A. Larson, Michelle M. Le Beau, Michael A. Caligiuri, Konstanze Döhner, Lars Bullinger, Paul Liu, Ruud Delwel, Guido Marcucci, Bob Löwenberg, Clara D. Bloomfield, Janet D. Rowley, Stefan K. Bohlander, Jianjun Chen,
To identify a robust prognostic gene expression signature as an independent predictor of survival of patients with acute myeloid leukemia (AML) and use it to improve established risk classification.Four independent sets totaling 499 patients with AML carrying various cytogenetic and molecular abnormalities were used as training sets. Two independent patient sets composed of 825 patients were used as validation sets. Notably, patients from different sets were treated with different protocols, and ...
Tópico(s): Retinoids in leukemia and cellular processes
2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Carlotta Granchi, Serena Fortunato, Serena Meini, Flavio Rizzolio, Isabella Caligiuri, Tiziano Tuccinardi, Hyang Yeon Lee, Paul J. Hergenrother, Filippo Minutolo,
Inhibition of lactate dehydrogenase (LDH) represents an innovative approach to tackle cancer because this peculiar glycolytic metabolism is characteristic of most invasive tumor cells. An investigation into the biological properties of saffron extracts led to the discover of their LDH-inhibition properties. In particular, the most important saffron components, crocetin, was found to inhibit LDH (IC50 = 54.9 ± 4.7 μM). This carotenoid was independently produced by chemical synthesis, and its LDH-inhibition ...
Tópico(s): Flavonoids in Medical Research
2017 - American Chemical Society | Journal of Agricultural and Food Chemistry
Ewa Mrózek, Paul Anderson, MA Caligiuri,
Tópico(s): Hematopoietic Stem Cell Transplantation
1996 - Elsevier BV | Blood
Savannah M D’Evelyn, Jihoon Jung, Ernesto Alvarado, Jill Baumgartner, Pete Caligiuri, R. Keala Hagmann, Sarah B. Henderson, Paul F. Hessburg, Sean Hopkins, Edward J. Kasner, Meg A. Krawchuk, Jennifer Krenz, Jamie M. Lydersen, Miriam E. Marlier, Yuta J. Masuda, Kerry L. Metlen, Gillian Mittelstaedt, Susan J. Prichard, Claire Schollaert, Edward B. Smith, Jens T. Stevens, Christopher W. Tessum, Carolyn Reeb-Whitaker, Joseph L. Wilkins, Nicholas H. Wolff, Leah M Wood, Ryan D. Haugo, June T. Spector,
Increasing wildfire size and severity across the western United States has created an environmental and social crisis that must be approached from a transdisciplinary perspective. Climate change and more than a century of fire exclusion and wildfire suppression have led to contemporary wildfires with more severe environmental impacts and human smoke exposure. Wildfires increase smoke exposure for broad swaths of the US population, though outdoor workers and socially disadvantaged groups with limited ...
Tópico(s): Urban Green Space and Health
2022 - Springer Science+Business Media | Current Environmental Health Reports
Paul Anderson, Michael A. Caligiuri, Jerome Ritz, S F Schlossman,
Tópico(s): CAR-T cell therapy research
1989 - Nature Portfolio | Nature
Michael A. Caligiuri, Christine Murray, Dedra Buchwald, Herbert Levine, Paul R. Cheney, Daniel L. Peterson, Anthony L. Komaroff, Jerome Ritz,
Natural killer (NK)3 cells are large granular lymphocytes that appear to play a significant role in the host's defense against viral infection. We performed an extensive phenotypic and functional characterization of NK cells on 41 patients with the chronic fatigue syndrome (CFS), or "chronic active Epstein-Barr virus infection" syndrome, and on 23 age- and sex-matched asymptomatic control subjects in an attempt to further characterize this illness. These studies demonstrated that a majority of patients ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
1987 - American Association of Immunologists | The Journal of Immunology
Lauren Wills, Jessica L. Ables, Kevin M. Braunscheidel, Stephanie P. B. Caligiuri, Karim S. Elayouby, Clémentine Fillinger, Masago Ishikawa, Janna K. Moen, Paul J. Kenny,
Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also regulate the aversive properties of nicotine, sensitivity to which decreases tobacco use and protects against tobacco use disorder. These opposing behavioral actions of nicotine reflect nAChR expression in brain reward and aversion circuits. nAChRs containing α 4 and β 2 subunits are responsible for the high-affinity nicotine ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2022 - American Society for Pharmacology and Experimental Therapeutics | Pharmacological Reviews
Brenda R. Kwak, Magnus Bäck, Marie‐Luce Bochaton‐Piallat, Giuseppina Caligiuri, Mat J.A.P. Daemen, Peter F. Davies, Imo E. Hoefer, Paul Holvoet, Hanjoong Jo, Rob Krams, Stéphanie Lehoux, Claudia Monaco, Sabine Steffens, Renu Virmani, Christian Weber, Jolanda J. Wentzel, Paul C. Evans,
Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall (radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress). The stresses and strains experienced by arteries influence the initiation of atherosclerotic lesions, which develop at regions of arteries that are exposed to complex blood flow. In addition, plaque progression and eventually plaque rupture is influenced by a complex interaction between biological and mechanical ...
Tópico(s): Cardiac Imaging and Diagnostics
2014 - Oxford University Press | European Heart Journal
Zejuan Li, Hao Huang, Yuanyuan Li, Xi Jiang, Ping Chen, Stephen Arnovitz, Michael D. Radmacher, Kati Maharry, Abdel G. Elkahloun, Xinan Yang, Chunjiang He, Miao He, Zhiyu Zhang, Konstanze Döhner, Mary Beth Neilly, Colles Price, Yves A. Lussier, Yanming Zhang, Richard A. Larson, Michelle M. Le Beau, Michael A. Caligiuri, Lars Bullinger, Peter J.M. Valk, Ruud Delwel, Bob Löwenberg, Paul Liu, Guido Marcucci, Clara D. Bloomfield, Janet D. Rowley, Jianjun Chen,
Abstract Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated with favorable overall survival in cytogenetically abnormal AML (CA-AML) patients. We further show that up-regulation of a gene signature composed of 4 potential miR-181 targets (including HOXA7, HOXA9, ...
Tópico(s): MicroRNA in disease regulation
2012 - Elsevier BV | Blood
Stephan Dreyer, Rosanna Upstill‐Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloïse Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker, Zachary Galluzzo, Holly Brunton, Richard Cunningham, Mathias Tesson, Craig Nourse, Ulla‐Maja Bailey, Marc D. Jones, Kim Moran‐Jones, Derek Wright, Fraser R. Duthie, Karin A. Oien, Lisa Evers, Colin J. McKay, Grant A. McGregor, Aditi Gulati, Rachel Brough, Ilirjana Bajrami, Stephan Pettitt, Michele L. Dziubinski, Juliana Candido, Frances R. Balkwill, Simon T. Barry, Robert Grützmann, Lola Rahib, Amber L. Johns, Marina Pajic, Fieke E. M. Froeling, Philip Beer, Elizabeth A. Musgrove, Gloria M. Petersen, Alan Ashworth, Margaret C. Frame, Howard C. Crawford, Diane M. Simeone, Chris Lord, Debabrata Mukhopadhyay, Christian Pilarsky, David A. Tuveson, Susanna L. Cooke, Nigel B. Jamieson, Jennifer P. Morton, Owen J. Sansom, Peter J. Bailey, Andrew V. Biankin, David K. Chang, Sarah Allison, Peter J. Bailey, Ulla‐Maja Bailey, Andrew V. Biankin, Dario Beraldi, Holly Brunton, Giuseppina Caligiuri, Euan Cameron, David K. Chang, Susanna L. Cooke, Richard Cunningham, Stephan Dreyer, Paul Grimwood, Shane Kelly, Eirini-Maria Lampraki, John L. Marshall, Sancha Martin, Brian McDade, Daniel L. McElroy, Elizabeth A. Musgrove, Craig Nourse, Viola Paulus-Hock, Donna Ramsay, Rosanna Upstill‐Goddard, Derek Wright, Marc D. Jones, Lisa Evers, Selma Rebus, Lola Rahib, Bryan Serrels, Jane Hair, Nigel B. Jamieson, Colin J. McKay, Paul Westwood, Nicola Williams, Fraser R. Duthie, Andrew V. Biankin, Amber L. Johns, Amanda Mawson, David K. Chang, Christopher J. Scarlett, Mary-Anne L. Brancato, Sarah J. Rowe, Skye H. Simpson, Mona Martyn-Smith, Michelle T. Thomas, Lorraine A. Chantrill, Venessa Chin, Angela Chou, Mark J. Cowley, Jeremy L. Humphris, Marc D. Jones, R. Scott Mead, Adnan M. Nagrial, Marina Pajic, Jessica Pettit, Mark Pinese, Ilse Rooman, Jianmin Wu, Tao Jiang, Renee DiPietro, Clare Watson, Angela Steinmann, Hong Ching Lee, Rachel Wong, Andreia V. Pinho, Marc Giry-Laterrière, Roger J. Daly, Elizabeth A. Musgrove, Robert L. Sutherland, Sean M. Grimmond, Nicola Waddell, Karin S. Kassahn, David K. Miller, Peter J. Wilson, Ann-Marie Patch, Sarah Song, Ivon Harliwong, Senel Idrisoglu, Craig Nourse, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani, Milena Gongora, Matthew J. Anderson, Oliver Holmes, Conrad Leonard, Darrin F. Taylor, Scott Wood, Christina Xu, Kátia Nones, J. Lynn Fink, Angelika N. Christ, Tim Bruxner, Nicole Cloonan, Felicity Newell, John V. Pearson, Peter J. Bailey, Michael C. Quinn, Shivashankar H. Nagaraj, Stephen H. Kazakoff, Nick M. Waddell, Keerthana Krisnan, Kelly Quek, David Wood, Jaswinder S. Samra, Anthony J. Gill, Nick Pavlakis, Alex Guminski, Christopher W. Toon, Ray Asghari, Neil D. Merrett, Darren Pavey, Amitabha Das, Peter H. Cosman, Kasim Ismail, Chelsie O’Connnor, Vincent Lam, Duncan McLeod, Henry Pleass, A. J. Richardson, Virginia James, James G. Kench, Caroline Cooper, David Joseph, Charbel Sandroussi, Michael Crawford, James Gallagher, Michael Texler, Cindy Forest, Andrew Laycock, Krishna Epari, Mo Ballal, David Fletcher, Sanjay Mukhedkar, Nigel Spry, Bastiaan DeBoer, Ming G. Chai, Nikolajs Zeps, Maria Beilin, Kynan Feeney, Nan Q. Nguyen, Andrew Ruszkiewicz, Chris Worthley, Chuan Tan, Tamara Debrencini, John Chen, Mark E. Brooke‐Smith, Virginia Papangelis, Henry H. K. Tang, Andrew P. Barbour, Andrew D. Clouston, Patrick Martin, Thomas O’Rourke, Amy Chiang, Jonathan W. Fawcett, Kellee Slater, Shinn Yeung, Michael Hatzifotis, Peter Hodgkinson, Christopher Christophi, Mehrdad Nikfarjam, Angela Mountain, Victorian Cancer Biobank, James R. Eshleman, Ralph H. Hruban, Anirban Maitra, Christine A. Iacobuzio‐Donahue, Richard D. Schulick, Christopher L. Wolfgang, Richard A. Morgan, Mary Hodgin, Aldo Scarpa, Rita T. Lawlor, Stefania Beghelli, Vincenzo Corbo, Maria Scardoni, Claudio Bassi, Margaret A. Tempero, Andrew V. Biankin, Sean M. Grimmond, David K. Chang, Elizabeth A. Musgrove, Marc D. Jones, Craig Nourse, Nigel B. Jamieson, Janet Graham, Andrew V. Biankin, David K. Chang, Nigel B. Jamieson, Janet Graham,
Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in PC to develop a biomarker-driven therapeutic strategy targeting DDR and replication stress in PC.
Tópico(s): Cancer Genomics and Diagnostics
2020 - Elsevier BV | Gastroenterology
Ting Lu, Rui Ma, Wenjuan Dong, Kun‐Yu Teng, Daniel S. Kollath, Zhiyao Li, Jinhee Yi, Christian Bustillos, Shoubao Ma, Lei Tian, Anthony G. Mansour, Zhenlong Li, Erik W. Settles, Jianying Zhang, Paul Keim, Bridget M. Barker, Michael A. Caligiuri, Jianhua Yu,
Abstract Engineered natural killer (NK) cells represent a promising option for immune therapy option due to their immediate availability in allogeneic settings. Severe acute diseases, such as COVID-19, require targeted and immediate intervention. Here we show engineering of NK cells to express (1) soluble interleukin-15 (sIL15) for enhancing their survival and (2) a chimeric antigen receptor (CAR) consisting of an extracellular domain of ACE2, targeting the spike protein of SARS-CoV-2. These CAR NK cells ( ...
Tópico(s): CAR-T cell therapy research
2022 - Nature Portfolio | Nature Communications
Wenjuan Dong, Heather Mead, Lei Tian, Jun‐Gyu Park, Juan Ignacio García, Sierra A. Jaramillo, Tasha Barr, Daniel S. Kollath, Vanessa K. Coyne, Nathan E. Stone, Ashley Jones, Jianying Zhang, Aimin Li, Li‐Shu Wang, Martha Milanes‐Yearsley, Jordi B. Torrelles, Luis Martínez‐Sobrido, Paul Keim, Bridget M. Barker, Michael A. Caligiuri, Jianhua Yu,
A comprehensive analysis and characterization of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe coronavirus disease 2019 (COVID-19) in humans is warranted for understating the virus and developing preventive and therapeutic agents. Here, we characterized the K18-hACE2 mouse model expressing human (h)ACE2 in mice, controlled by the human keratin 18 (K18) promoter, in the epithelia, including airway epithelial cells where SARS-CoV-2 infections ...
Tópico(s): Immune responses and vaccinations
2021 - American Society for Microbiology | Journal of Virology
Sunil M. Kurian, H Le-Niculescu, Sagar D. Patel, D. S. Bertram, Jason Davis, Charles C. Dike, N Yehyawi, Paul H. Lysaker, J Dustin, Michael P. Caligiuri, James B. Lohr, Debomoy K. Lahiri, John I. Nürnberger, Stephen V. Faraone, Mark A. Geyer, Ming T. Tsuang, Nicholas J. Schork, Daniel R. Salomon, Alexander B. Niculescu,
There are to date no objective clinical laboratory blood tests for psychotic disease states. We provide proof of principle for a convergent functional genomics (CFG) approach to help identify and prioritize blood biomarkers for two key psychotic symptoms, one sensory (hallucinations) and one cognitive (delusions). We used gene expression profiling in whole blood samples from patients with schizophrenia and related disorders, with phenotypic information collected at the time of blood draw, then cross- ...
Tópico(s): Tryptophan and brain disorders
2009 - Springer Nature | Molecular Psychiatry
Stephanie P. B. Caligiuri, Paul J. Kenny,
To truly reduce the rates of chronic kidney disease, a root cause of kidney damage, obesity, must be targeted. Weight loss is often unsustainable because imbalances in satiety regulators are frequently not addressed to ensure maintenance of weight loss. In a recent study, gastric bypass surgery rebalanced satiety signals through resensitization of the gut-brain axis in obesity. This research may lead to noninvasive strategies to reduce obesity and obesity-related kidney disease. To truly reduce ...
Tópico(s): Diet, Metabolism, and Disease
2017 - Elsevier BV | Kidney International
Xiaozhang Zheng, Paul Bauer, Timm Baumeister, Alexandre J. Buckmelter, Maureen Caligiuri, Karl H. Clodfelter, Bingsong Han, Yen‐Ching Ho, Nikolai Kley, Jian Lin, Dominic J. Reynolds, Geeta Sharma, Chase C. Smith, Zhongguo Wang, Peter S. Dragovich, Angela Oh, Weiru Wang, Mark Zak, Janet Gunzner-Toste, Gui‐Ling Zhao, Po‐wai Yuen, Kenneth W. Bair,
Nicotinamide phosphoribosyltransferase (Nampt) is a promising anticancer target. Virtual screening identified a thiourea analogue, compound 5, as a novel highly potent Nampt inhibitor. Guided by the cocrystal structure of 5, SAR exploration revealed that the corresponding urea compound 7 exhibited similar potency with an improved solubility profile. These studies also indicated that a 3-pyridyl group was the preferred substituent at one inhibitor terminus and also identified a urea moiety as the ...
Tópico(s): Sirtuins and Resveratrol in Medicine
2013 - American Chemical Society | Journal of Medicinal Chemistry
Janet Gunzner-Toste, Gui‐Ling Zhao, Paul Bauer, Timm Baumeister, Alexandre J. Buckmelter, Maureen Caligiuri, Karl H. Clodfelter, Bang Fu, Bingsong Han, Yen‐Ching Ho, Nikolai Kley, Xiaorong Liang, Bianca M. Liederer, Jian Lin, Sophie Mukadam, Thomas O’Brien, Angela Oh, Dominic J. Reynolds, Geeta Sharma, Nicholas J. Skelton, Chase C. Smith, Jasleen K. Sodhi, Weiru Wang, Zhongguo Wang, Yang Xiao, Po‐wai Yuen, Mark Zak, Lei Zhang, Xiaozhang Zheng, Kenneth W. Bair, Peter S. Dragovich,
Potent, reversible inhibition of the cytochrome P450 CYP2C9 isoform was observed in a series of urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. This unwanted property was successfully removed from the described inhibitors through a combination of structure-based design and medicinal chemistry activities. An optimized compound which did not inhibit CYP2C9 exhibited potent anti-NAMPT activity (17; BC NAMPT IC50 = 3 nM; A2780 antiproliferative IC50 = 70 nM), good mouse PK properties, ...
Tópico(s): PARP inhibition in cancer therapy
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Xiaozhang Zheng, Paul Bauer, Timm Baumeister, Alexandre J. Buckmelter, Maureen Caligiuri, Karl H. Clodfelter, Bingsong Han, Yen‐Ching Ho, Nikolai Kley, Jian Lin, Dominic J. Reynolds, Geeta Sharma, Chase C. Smith, Zhongguo Wang, Peter S. Dragovich, Janet Gunzner-Toste, Bianca M. Liederer, Justin Q. Ly, Thomas O’Brien, Angela Oh, Leslie Wang, Weiru Wang, Yang Xiao, Mark Zak, Gui‐Ling Zhao, Po‐wai Yuen, Kenneth W. Bair,
Crystal structures of several urea- and thiourea-derived compounds in complex with the nicotinamide phosphoribosyltransferase (Nampt) protein were utilized to design a potent amide-containing inhibitor bearing an aza-indole moiety (7, Nampt BC IC50 = 9.0 nM, A2780 cell proliferation IC50 = 10 nM). The Nampt–7 cocrystal structure was subsequently obtained and enabled the design of additional amide-containing inhibitors which incorporated various other fused 6,5-heterocyclic moieties and biaryl sulfone ...
Tópico(s): HIV/AIDS drug development and treatment
2013 - American Chemical Society | Journal of Medicinal Chemistry
Jagadeesh Bayary, Sooryasarathi Dasgupta, Namita Misra, Amal Ephrem, Jean‐Paul Duong Van Huyen, Sandrine Delignat, Gazzala Hassan, Giuseppina Caligiuri, Antonino Nicoletti, Sébastien Lacroix‐Desmazes, Michel D. Kazatchkine, Srini V. Kaveri,
Intravenous immunoglobulin (IGIV) has increasingly been used for the treatment of autoimmune and systemic inflammatory diseases in addition to supportive therapy of immunodeficient patients. IGIV is beneficial in several diseases, including acute and chronic/relapsing diseases, autoimmune diseases and inflammatory disorders. Therapeutic efficacy of IGIV has also been established in a number of dermatologic diseases. Although a considerable progress has been made in understanding the mechanisms by ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2005 - Elsevier BV | International Immunopharmacology
Namita Misra, Jagadeesh Bayary, Sooryasarathi Dasgupta, Amal Ephrem, Jean‐Paul Duong Van Huyen, Sandrine Delignat, Gazzala Hassan, Giuseppina Caligiuri, Antonino Nicoletti, Sébastien Lacroix‐Desmazes, Michel D. Kazatchkine, Srini V. Kaveri,
Tópico(s): Immune Cell Function and Interaction
2005 - Springer Nature | Clinical Reviews in Allergy & Immunology
Abstract: The free movement of services is a fundamental tenet of the European Union's Common Market. Gambling services' free movement, however, has long been obstructed by municipal gambling restrictions. One such restriction in place in Sweden authorized the prosecution of two newspaper editors for publishing advertisements of foreign-based online gambling operators. In the course of the editors' appeal from their conviction, the Swedish courts referred questions to the European Court of Justice ...
Tópico(s): Corporate Governance and Law
2012 - Routledge | Boston College international and comparative law review
Xiaozhang Zheng, Kenneth W. Bair, Paul Bauer, Timm Baumeister, Krista K. Bowman, Alexandre J. Buckmelter, Maureen Caligiuri, Karl H. Clodfelter, Y. Feng, Bingsong Han, Yen‐Ching Ho, Nikolai Kley, Hong Li, Xiaorong Liang, Bianca M. Liederer, Jian Lin, Justin Q. Ly, Thomas O’Brien, Jason Oeh, Angela Oh, Dominic J. Reynolds, Deepak Sampath, Geeta Sharma, Nicholas J. Skelton, Chase C. Smith, Jarrod R. Tremayne, Leslie Wang, Weiru Wang, Zhongguo Wang, Hongxing Wu, Jian Wu, Yang Xiao, Guangxing Yang, Po‐wai Yuen, Mark Zak, Peter S. Dragovich,
Potent, 1H-pyrazolo[3,4-b]pyridine-containing inhibitors of the human nicotinamide phosphoribosyltransferase (NAMPT) enzyme were identified using structure-based design techniques. Many of these compounds exhibited nanomolar antiproliferation activities against human tumor lines in in vitro cell culture experiments, and a representative example (compound 26) demonstrated encouraging in vivo efficacy in a mouse xenograft tumor model derived from the A2780 cell line. This molecule also exhibited reduced ...
Tópico(s): Sirtuins and Resveratrol in Medicine
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Jie Yang, Qian Tao, Ian W. Flinn, Paul G. Murray, Linda Post, H. Ma, Steven Piantadosi, Michael A. Caligiuri, Richard F. Ambinder,
Tópico(s): Eosinophilic Disorders and Syndromes
2000 - Elsevier BV | Blood
Jie Yang, Qian Tao, Ian W. Flinn, Paul G. Murray, Linda Post, H. Ma, Steven Piantadosi, Michael A. Caligiuri, Richard F. Ambinder,
Tópico(s): Eosinophilic Disorders and Syndromes
2000 - Elsevier BV | Blood
Sara E. Martin del Campo, Kala Levine, Bethany L. Mundy-Bosse, Valerie P. Grignol, Ene T. Fairchild, Amanda R. Campbell, Prashant Trikha, Thomas A. Mace, Bonnie Paul, Alena Cristina Jaime‐Ramirez, Joseph Markowitz, Sri Vidya Kondadasula, Kristan Guenterberg, Susan McClory, Volodymyr Karpa, Xueliang Pan, Thomas Olencki, J. Paul Monk, Amir Mortazavi, Susheela Tridandapani, Gregory B. Lesinski, John C. Byrd, Michael A. Caligiuri, Manisha H. Shah, William E. Carson,
Abstract Sorafenib is an oral multikinase inhibitor that was originally developed as a Raf kinase inhibitor. We hypothesized that sorafenib would also have inhibitory effects on cytokine signaling pathways in immune cells. PBMCs from normal donors were treated with varying concentrations of sorafenib and stimulated with IFN-α or IL-2. Phosphorylation of STAT1 and STAT5 was measured by flow cytometry and confirmed by immunoblot analysis. Changes in IFN-α– and IL-2–stimulated gene expression were ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2015 - American Association of Immunologists | The Journal of Immunology
Elizabeth L. McMichael, Brooke Benner, Lakhvir S. Atwal, Nicholas B. Courtney, Xiaokui Mo, Melanie E. Davis, Amanda R. Campbell, Megan Duggan, Kallan Williams, Kyle Martin, Kala Levine, Gonzalo N. Olaverria Salavaggione, Tiffany Noel, Akaansha Ganju, Sarvani Uppati, Bonnie Paul, Thomas Olencki, Theodoros N. Teknos, P. Savvides, Susheela Tridandapani, John C. Byrd, Michael A. Caligiuri, Stephen V. Liu, William E. Carson,
Abstract Purpose: mAbs including cetuximab can induce antibody-dependent cellular cytotoxicity (ADCC) and cytokine production mediated via innate immune cells with the ability to recognize mAb-coated tumors. Preclinical modeling has shown that costimulation of natural killer (NK) cells via the Fc receptor and the IL12 receptor promotes NK-cell–mediated ADCC and production of cytokines. Patients and Methods: This phase I/II trial evaluated the combination of cetuximab with IL12 for the treatment of ...
Tópico(s): Colorectal and Anal Carcinomas
2019 - American Association for Cancer Research | Clinical Cancer Research
Stephanie P. B. Caligiuri, Paul J. Kenny,
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2020 - Springer Nature | Neuropsychopharmacology
Christina Wyatt, Marianne Camargo, Steven G. Coca, Stephanie P. B. Caligiuri, Paul J. Kenny, Raghu Tadagavadi, William Reeves, Daniel L. Galvan, Farhad R. Danesh, Tadashi Takeuchi, H. Ohno, Naoko Satoh‐Takayama, Carmen A. Peralta, Michelle M. Estrella, Brendan Crawford, Debbie S. Gipson, Helen C. Looker, Robert H. Nelson, Markus Ketteler, Geoffrey A. Block, Pieter Evenepoel, Masafumi Fukagawa, Charles A. Herzog, Linda McCann, Sharon M. Moe, Rukshana Shroff, Marcello Tonelli, Nigel D. Toussaint, Marc Vervloet, Mary Open,
2017 - Elsevier BV | Kidney International