John Huxley, Malcolm Brown, Gervase Jackson-Stops, Victoria Glendinning, Will Ellsworth-Jones, Richard Brooks Communications Correspondent, Philip Norman, Anne Spackman, Ann Gould, Mike Bygrave, John Peter, Martin Easteal Public sector director, George Jones Political Correspondent, Chris Tighe, Ruskin Spear, Brian Deer Social Affairs Correspondent, Graham Rose, Mark Lawson, Shelley Gare, John Huxley Industrial Editor, Angela Wilkers, Henry Porter, Dalbert Hallenstein, Jason Tomas, Jancis Robinson, John Westwell, Kenneth Baker, Brenda Marsh, P Hall Director, Irwin Stelzer, John Newell, Peter Godwin, Stephen Lewis, Mick Brown, Deryk Brown, David Dougill, Veronica Horwell, John Witherow, Sarah Helm, Gerry Woolf, Peter Kemp, Norman Harris, Anne Jacobs, David Connett, Alice McCann, Geoff Whitten, Alice mORO, Will Ellsworth Jones, E Huggett, Rose Shepherd, Anita Brookner, M Price, Bernard Cafferty, Brian Moynahan, Roger Eglin, Angela Newing, Robert Buhler, Paul Driver, Tim Rayment, Michael Imeson, Nick Gilbert, John Hopkins, Terry Wilkinson, Eric Marsden, Peter Wilsher, Stephen Pile, Eric Sams, Gareth Huw Davies, Diana Wright, Julia Glenn, Stephen Jones, Meriel McCooey, Norman Lebrecht, Brian Silcock, Keith Wheatley, Dilys Powell, Alan Budd, Tim Heald, Brough Scott, Caroline McGhie, Tony Osman, Louise Branson, Simon Winchester, Barrie Penrose, Elliott Abrams Assistant Secretary, Eddy Shah, Tim Blackstone, Ian Jack, Michael Jones Political Editor, Mike Smith, David Green, Godfrey Smith, Philip Beresford, Neil Collins Editor, Andrew Stephen, Brian Glanville, Gidley Wheeler, David Sinclair, Michael Green, Rowena Webster, Neil Collins City Editor, Roy Isacowitz, Minette Marrin, Ian Williams, Peter Jenkins, Marina Vaizey, Andrew Graham-Dixon, Robert Whymant, George Jones, Nick Higham, Tony Hetherington, Jon Connell, Hugh Trevor-Roper, Boris Schapiro,
... Idries Shah Genetic engineering White Water by Joyce Reiser Kornblatt/Chatto £9.95 pp217 Love and fate ... Heather Valley The Naked Truth about the Raymonds Paul Raymond and his daughter Finland naturally Jazzy and ...
1986 - Gale Group | Sunday Times HA GDA
Hansong Cheng, David Reiser, Paul M. Mathias, Kenneth L. Baumert, Sheldon W. Dean,
... 100), and Cr(100)Hansong Cheng, David B. Reiser, Paul M. Mathias, Kenneth Baumert, and Sheldon W. Dean ...
Tópico(s): Environmental remediation with nanomaterials
1995 - American Chemical Society | The Journal of Physical Chemistry
Ernest Newman, H. S. Staveley-Hill, H. M. Abrahams, W. D., Yarborough, Geo Prime, Stewart F. Joyce, Sais, Ralph Straus, Herbert Sidebotham, H C Minchin, J. Blacklook, MacMillan, J. M. Bulloch, Archibald Colbeck, H. Heydeman, G. A. Tomlin, E. V. Lucas, H. Carr Smith, James Agate, Frank Rutter, E. L., Esmond Knight, H. M. Winearls, Vernon Smith, L Van Vliet, Louis E. Fawous, George C. Stead, Dragoon, Desmond MacCarthy, Sydney W Carroll, A. Chensnier Du Chesne, E. I. Shadbolt, W. H. W., Paul Weden, W. W. Hadley, N. P., Wickham Steed, John Reynolds, J. M. B., Arnold C. Taylor, Mary Hudson, Charles Weld Forester, H. M. J., Helena Harrison, H. F., Margaret J Tuke, Philip Guedalla, Charles A. Cook, Etonian, C. Stewart Caine, Murri Monocrieff, R. J. Barrett Financial Editor, (Rev.) R. T. Marshall, Harold Cox,
... is "Albert Einstein: a Bingraphical Portrait." By Anton Reiser, with a foreword by Albert Einstein. (Thornton Butterworth. ...
1931 - Gale Group | Sunday Times HA GDA
... hypoxiaThomas L. Clanton, Valerie P. Wright, Peter J. Reiser, Paul F. Klawitter, and Nanduri R. Prabhakar1 June 2001 | ...
Tópico(s): Mitochondrial Function and Pathology
1972 - American Physiological Society | Physiological Reviews
The literature on the viability of ancient bacteria is negligible. Lipmann cultured some bacteria from Pennsylvanian coal, and ZoBell cultured bacteria from oil-brines. In a letter to Tasch dated March 29, 1951, ZoBell wrote in response to a question about viability of ancient bacteria: Bacteria as individuals might have infinite longevity. They might be capable of resting in suspended animation for unlimited periods of time and some might have survived in this state since the PreCambrian. The evidence ...
Tópico(s): Methane Hydrates and Related Phenomena
1960 - Kansas Academy of Science | Transactions of the Kansas Academy of Science
Maren K. Schroeder, Bin Liu, Robert G. Hinshaw, Mi‐Ae Park, Shuyan Wang, Shipra Dubey, Grace Geyu Liu, Qiaoqiao Shi, Peter Holton, Vladimı́r Reiser, Paul A. Jones, William Trigg, Marcelo F. Di Carli, Barbara J. Caldarone, Jacqueline P. Williams, M. Kerry O’Banion, Cynthia A. Lemere,
Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that 56Fe irradiation, a significant component of space radiation, may be more harmful to males than to females and worsen Alzheimer's disease pathology in genetically vulnerable models. Yet, research on the long-term, sex- and genotype-specific effects of 56Fe ...
Tópico(s): Mitochondrial Function and Pathology
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Bin Liu, Robert G. Hinshaw, Kevin X. Le, Mi‐Ae Park, Shuyan Wang, Anthony P. Belanger, Shipra Dubey, Jeffrey L. Frost, Qiaoqiao Shi, Peter Holton, Lee Trojanczyk, Vladimı́r Reiser, Paul A. Jones, William Trigg, Marcelo F. Di Carli, Paul J. Lorello, Barbara J. Caldarone, Jacqueline P. Williams, M. Kerry O’Banion, Cynthia A. Lemere,
Abstract Space travel will expose people to high-energy, heavy particle radiation, and the cognitive deficits induced by this exposure are not well understood. To investigate the short-term effects of space radiation, we irradiated 4-month-old Alzheimer’s disease (AD)-like transgenic (Tg) mice and wildtype (WT) littermates with a single, whole-body dose of 10 or 50 cGy 56 Fe ions (1 GeV/u) at Brookhaven National Laboratory. At ~1.5 months post irradiation, behavioural testing showed sex-, genotype-, ...
Tópico(s): Cancer-related cognitive impairment studies
2019 - Nature Portfolio | Scientific Reports
Michelle L. James, Nadia P. Belichenko, Adam J. Shuhendler, Aileen Hoehne, Lauren Andrews, Christina Condon, Thuy‐Vi V. Nguyen, Vladimer Reiser, Paul A. Jones, William Trigg, Jianghong Rao, Sanjiv S. Gambhir, Frank M. Longo,
Microglial activation is a key pathological feature of Alzheimer's disease (AD).PET imaging of translocator protein 18 kDa (TSPO) is a strategy to detect microglial activation in vivo.Here we assessed flutriciclamide ([ 18 F]GE-180), a new second-generation TSPO-PET radiotracer, for its ability to monitor response to LM11A-31, a novel AD therapeutic in clinical trials.AD mice displaying pathology were treated orally with LM11A-31 for 3 months.Subsequent [ 18 F]GE-180-PET imaging revealed significantly ...
Tópico(s): S100 Proteins and Annexins
2017 - Ivyspring International Publisher | Theranostics
Bin Liu, Kevin X. Le, Mi‐Ae Park, Shuyan Wang, Anthony P. Belanger, Shipra Dubey, Jeffrey L. Frost, Peter Holton, Vladimı́r Reiser, Paul A. Jones, William Trigg, Marcelo F. Di Carli, Cynthia A. Lemere,
Alzheimer's disease (AD) is the most common cause of dementia. Neuroinflammation appears to play an important role in AD pathogenesis. Ligands of the 18 kDa translocator protein (TSPO), a marker for activated microglia, have been used as positron emission tomography (PET) tracers to reflect neuroinflammation in humans and mouse models. Here, we used the novel TSPO-targeted PET tracer 18 F-GE180 (flutriciclamide) to investigate differences in neuroinflammation between young and old WT and APP/PS1dE9 ...
Tópico(s): S100 Proteins and Annexins
2015 - Society for Neuroscience | Journal of Neuroscience
Pradip Maity, Quirin M. Kainz, Saqib Faisal, Alan Rolfe, Thiwanka B. Samarakoon, Fatima Z. Basha, Oliver Reiser, Paul R. Hanson,
The utilization of a monomer-on-monomer (MoM) intramolecular Mitsunobu cyclization reaction employing norbornenyl-tagged (Nb-tagged) reagents is reported for the synthesis of benzofused thiadiazepine-dioxides. Facile purification was achieved viaring-opening metathesis (ROM) polymerization initiated by one of three metathesis catalyst methods: (i) free metathesis catalyst, (ii) surface-initiated catalyst-armed silica, or (iii) surface-initiated catalyst-armed Co/C magnetic nanoparticles.
Tópico(s): Catalytic Cross-Coupling Reactions
2011 - Royal Society of Chemistry | Chemical Communications
Pradip Maity, Alan Rolfe, Thiwanka B. Samarakoon, Saqib Faisal, Ryan D. Kurtz, Toby R. Long, Alexander Schätz, Daniel L. Flynn, Robert N. Grass, Wendelin J. Stark, Oliver Reiser, Paul R. Hanson,
A monomer-on-monomer (MoM) Mitsunobu reaction utilizing norbornenyl-tagged (Nb-tagged) reagents is reported, whereby purification was rapidly achieved by employing ring-opening metathesis polymerization, which was initiated by any of three methods utilizing Grubbs catalyst: (i) free catalyst in solution, (ii) surface-initiated catalyst-armed silica, or (iii) surface-initiated catalyst-armed Co/C magnetic nanoparticles.
Tópico(s): Microbial Natural Products and Biosynthesis
2010 - American Chemical Society | Organic Letters
Hansong Cheng, David Reiser, Paul M. Mathias, Kenneth L. Baumert, Sheldon W. Dean,
Nitriding is a chemical process that corrodes metal surfaces. Understanding the reaction mechanisms presents a considerable challenge both theoretically and experimentally. Using density functional theory (DFT) and a cluster surface model, we have investigated the structures and energetics for NH3 adsorption and decomposition processes at the on-top and 4-fold-hollow sites of the Nb(100) surface. We show that the preferred adsorption mode for NH3 is the on-top site, that NH2 can reside on both modes, ...
Tópico(s): MXene and MAX Phase Materials
1996 - American Chemical Society | The Journal of Physical Chemistry
Thomas L. Clanton, Valerie P. Wright, Peter J. Reiser, Paul F. Klawitter, Nanduri R. Prabhakar,
Intermittent hypoxia (IH), associated with obstructive sleep apnea, initiates adaptive physiological responses in a variety of organs. Little is known about its influence on diaphragm. IH was simulated by exposing rats to alternating 15-s cycles of 5% O 2 and 21% O 2 for 5 min, 9 sets/h, 8 h/day, for 10 days. Controls did not experience IH. Diaphragms were excised 20–36 h after IH. Diaphragm bundles were studied in vitro or analyzed for myosin heavy chain isoform composition. No differences in maximum ...
Tópico(s): Obstructive Sleep Apnea Research
2001 - American Physiological Society | Journal of Applied Physiology
Henrik J. Michaely, Kambiz Nael, Stefan O. Schoenberg, Gerhard Laub, Maximilian F. Reiser, J. Paul Finn, Stefan G. Ruehm,
We sought to assess the feasibility of magnetic resonance imaging to evaluate cardiac function at 3.0 T compared with 1.5 T.In a prospective intraindividual comparative study, 12 volunteers (range, 18-54 years), and 2 patients (range, 43-53 years) underwent cardiac cine magnetic resonance at both 3.0 T and 1.5 T. Data were acquired both with a steady-state free precession sequence (SSFP) and a spoiled gradient echo (SGE) sequence. If necessary, a frequency scout was used to correct for off-resonance ...
Tópico(s): Atomic and Subatomic Physics Research
2006 - Lippincott Williams & Wilkins | Investigative Radiology
Produção Nacional
Revisado por pares
Andrey R. da Silva, Ana Carolina de Assis Moura Ghirardi, Matheus Rutzen Reiser, Stephan Paul,
Summary Objectives The purpose of this work was twofold. First, we aimed to develop an exact analytical model for tubes used in semi-occluded vocal tract exercises to gain a quantitative insight into the relationship between flow resistance and the tube's geometric parameters. The second goal was to provide an isometric resistance chart that can be used by clinicians to indicate either the diameter or the length of a tube, so as to provide the same flow resistance of a reference tube. Methods The theory ...
Tópico(s): Music and Audio Processing
2018 - Elsevier BV | Journal of Voice
Hector F. DeLuca, Sheldon Reiser, H. Steenbock, Paul Kaesberg,
An electron microscopic examination has been made of thin sections of kidney mitochondria isolated in 0.44 M sucrose from vitamin D deficient rats and from vitamin D treated rats. Vitamin D deficiency resulted in swollen and morphologically damaged mitochondria characterized by large intercristal spaces and disrupted cristal systems. These changes were prevented by vitamin D.
Tópico(s): Diet and metabolism studies
1960 - Elsevier BV | Biochimica et Biophysica Acta
Peifen Zhang, Tanya Berardini, Dustin Ebert, Qian Li, Huaiyu Mi, Anushya Muruganujan, Trilok Prithvi, Leonore Reiser, Swapnil Sawant, Paul D. Thomas, Eva Huala,
We aim to enable the accurate and efficient transfer of knowledge about gene function gained from
Tópico(s): Plant Gene Expression Analysis
2020 - Wiley | Plant Direct
Michael Simmler, Lisa Ciadamidaro, Rainer Schulin, Paula Madejón, René Reiser, Lynne Clucas, Paul Weber, Brett Robinson,
Repeated application of Cd-rich phosphate fertilizers can lead to the accumulation of this nonessential element in soil. This can result in increased plant uptake, with possible breaches of food or feed safety standards. We aimed to determine whether lignite (brown coal) can reduce Cd solubility and plant uptake in New Zealand pasture soils. In batch sorption experiments, we tested the capacity of lignite and lignite-soil mixtures to sorb Cd at various soil pH and Cd loadings. Over a pH range of ...
Tópico(s): Coal and Its By-products
2013 - American Chemical Society | Environmental Science & Technology
Hadas Pade, Daniel O. Taube, Annette Aalborg, Paul J. Reiser,
ABSTRACT ABSTRACT The immediate and long-term effects of a Parent Child Interaction Therapy (PCIT) derived program offered at a Kaiser Permanente facility were evaluated. There were 73 participants in the initial sample and 23 in the 5–6 year follow-up sample. Child behaviors improved significantly immediately following treatment and some improvements were maintained at follow-up. Over 75% of the follow-up participants utilized additional therapy services following completion. Thus, sustained improvements ...
Tópico(s): Child Development and Digital Technology
2006 - Taylor & Francis | Child & Family Behavior Therapy
Elissa J. Schwartz, Andrea Cara, Hans Snoeck, Michael D. Ross, Masaaki Sunamoto, Jochen Reiser, Peter Mündel, Paul E. Klotman,
Abstract. Human immunodeficiency virus—associated nephropathy (HIVAN) affects up to 10% of HIV-positive black adults and children and is the leading cause of renal disease in infected individuals. The disease is characterized by proliferation of renal epithelial cells, both glomerular and tubular. Diseased kidneys are enlarged, and glomerular visceral epithelial cells (podocytes) express proliferation markers. In a transgenic murine model of HIVAN expressing a deletion construct of HIV-1, the identical ...
Tópico(s): HIV/AIDS drug development and treatment
2001 - American Society of Nephrology | Journal of the American Society of Nephrology
Brian L Huckstorf, Glenn R. Slocum, James Bain, Paul M Reiser, F Sedlák, Margaret T.T. Wong‐Riley, Danny A. Riley,
We hypothesized that hindlimb suspension unloading of 8-day-old neonatal rats would disrupt the normal development of muscle fiber types and the motor innervation of the antigravity (weightbearing) soleus muscles but not extensor digitorum longus (EDL) muscles. Five rats were suspended 4.5 h and returned 1.5 h to the dam for nursing on a 24 h cycle for 9 days. To control for isolation from the dam, the remaining five littermates were removed on the same schedule but not suspended. Another litter of ...
Tópico(s): Cerebral Palsy and Movement Disorders
2000 - Elsevier BV | Developmental Brain Research
Paul A. Reiser, Elliot F. Wyner,
An arc model for a high-pressure sodium lamp is developed which relates the position of the peaks of the self-absorbed 3S-3P sodium resonance D line to the operating densities and pressures of sodium and mercury. Vapor pressure equations for a Na-Hg amalgam are derived and used to relate the pressures to the temperature and molar ratio of the amalgam reservoir. Allowing for change in amalgam composition due to preferential evaporation of Hg, the amalgam and vapor pressure data are then related to ...
Tópico(s): Welding Techniques and Residual Stresses
1985 - American Institute of Physics | Journal of Applied Physics
David S. Siegel, Donna Weber, Constantine S. Mitsiades, Syed Rizvi, J. Garcia‐Vargas, J. Howe, David Reiser, Kenneth C. Anderson, Paul G. Richardson,
Abstract Introduction: Multiple myeloma (MM) is the second most common hematologic malignancy after non-Hodgkin’s lymphoma and despite recent advances in therapy, including the introduction of thalidomide, bortezomib, and lenalidomide, remains incurable. Vorinostat is an inhibitor of Class I and II histone deacetylases, which play key roles in the regulation of both transcriptional and post-transcriptional activity in a variety of tumor types, including MM. This histone deacetylase inhibitor has ...
Tópico(s): Multiple Myeloma Research and Treatments
2008 - Elsevier BV | Blood
Yutai Li, William T. Zimmerman, M K Gorman, R. W. Reiser, Arthur J. Fogiel, Paul E. Haney,
A laboratory study was conducted to determine the degradation rates and identify major metabolites of the herbicide metsulfuron-methyl in sterile and non-sterile aerobic soils in the dark at 20°C. Both [phenyl-U-14C]- and [triazine-2-14C]metsulfuron-methyl were used. The soil was treated with [14C]metsulfuron-methyl (0.1 mg kg−1) and incubated in flow-through systems for one year. The degradation rate constants, DT50, and DT90 were obtained based on the first-order and biphasic models. The DT50 (time ...
Tópico(s): Environmental Toxicology and Ecotoxicology
1999 - Wiley | Pesticide Science
Gerburg Keilhoff, Bertolt Seidel, Michael Reiser, Andreas Stanarius, Paul L. Huang, B. Bogerts, Gerald Wolf, Hans‐Gert Bernstein,
The relevance of NO in neuroendocrine signalling has been investigated by analysis of cellular expression of pro-opiomelanocortin (POMC) and the POMC-derived peptides beta-endorphin, alpha-melanocyte stimulating hormone and adrenocorticotropin. Expression patterns were studied in the pituitary gland of 150-day old wild-type and neuronal-NOS (nNOS) knock-out mice by using immunohistochemistry, in situ hybridization and Northern blot analysis. Remaining NO-generating capacities in the knock-out mice ...
Tópico(s): Neuropeptides and Animal Physiology
2001 - Elsevier BV | Acta Histochemica
Guanghua Yang, Qian Zhong, Wen Huang, Jakob Reiser, Paul Schwarzenberger,
In principle, transient nongenetic modification of a noninfectious gene transfer virus enabling a one time infection and transduction of human cells could eliminate the risk of formation of replication competent virus. Formation of a molecular conjugate vector by conjugation of noninfective ecotropic murine Moloney leukemia virus to polylysine (eMMLV-PL) enabled high-efficiency transduction of human HPC using in vitro and in vivo assays. Xenotransplanted NOD-SCID mice durably expressed the transgene ...
Tópico(s): Viral gastroenteritis research and epidemiology
2005 - Springer Nature | Cancer Gene Therapy
Georg M. Lauer, Kei Ouchi, Raymond T. Chung, Tam Nguyen, Cheryl L. Day, Deborah R. Purkis, Markus Reiser, Arthur Y. Kim, Michaela Lucas, Paul Klenerman, Bruce D. Walker,
ABSTRACT The hepatitis C virus (HCV)-specific CD8 + -T-cell response is thought to play a critical role in HCV infection. Studies of these responses have largely relied on the analysis of a small number of previously described or predicted HCV epitopes, mostly restricted by HLA A2. In order to determine the actual breadth and magnitude of CD8 + -T-cell responses in the context of diverse HLA class I alleles, we performed a comprehensive analysis of responses to all expressed HCV proteins. By using a panel ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2002 - American Society for Microbiology | Journal of Virology
Danielle Balériaux, Cesare Colosimo, J. Ruscalleda, M. Korves, Gerhard Schneider, K. Bohndorf, G. Bongartz, Mark A. van Buchem, Maximilian F. Reiser, K. Sartor, Michael W. Bourne, Paul M. Parizel, G.R. Cherryman, Isabella Salerio, La A. Noce, G Pirovano, M. Kirchin, Alberto Spinazzi,
Tópico(s): Lanthanide and Transition Metal Complexes
2002 - Springer Science+Business Media | Neuroradiology
Joel M. Bernstein, Cheryl Allen, Gary Rich, Diane Dryja, Paul Bina, Raoul Reiser, Mark Ballow, Gregory E. Wilding,
Abstract Objectives/Hypothesis: Recent studies have suggested that Staphylococcus aureus secrete exotoxins that may act as superantigens and upregulate the variable beta region of lymphocytes in chronic hyperplasticsinusitis with nasal polyposis (CHSwNP). The aim of this study was to add further information for correlating the presence of staphylococcal species and the upregulation of the V β region of both nasal polyp lymphocytes and peripheral blood lymphocytes. Furthermore, IgE‐mediated hypersensitivity ...
Tópico(s): Drug-Induced Adverse Reactions
2010 - Wiley | The Laryngoscope
... A, von Ziegler F, Becker A, Nikolau K, Paul S, Wintersperger B, Reiser M, Becker CR, Steinbeck G, Boekstegers P. Quantification ...
Tópico(s): Acute Myocardial Infarction Research
2008 - Lippincott Williams & Wilkins | Circulation