John Coleman, William Kay, Andrew Baker, Victoria Glendinning, Will Ellsworth-Jones, Jim Tucker, John Forsyth, Jon Swain, Dr Nigel Higson, Chris Tighe, Stanislas Klossowski de Rola, Nick Gilbert Deputy City Editor, Peter Harland, Peter Calvocoressi, Berry Ritchie, Graham Rose, John Diamond, Sheridan Morley, Donald MacIntyre Labour Editor, Antony Terry, Robin Morgan, Muriel Bowen, Adam Mars-Jones, M. E., John Whale, Julian Symons, Dalbert Hallenstein, Jason Tomas, Mark Hosenball, Henry Porter, Jancis Robinson, Brian Ganville, Henry Brandon, John Coates, Robert Hewison, Deryk Brown, Mick Brown, David Dougill, Gill Brown, Philip Knightley, Robin Wright, Miss M. W. Shropshire, Joe Irving, Bradley Smith, Cliff Temple, Eric Korn, L Baker, Christine Walker, Derek Jewell, W. L. H. Melksham, Egon Ronay, Peter Watson, David Cairns, Marina Warner, Norman Harris, Frederic Rephael, Donald Macintyre, Peter Ackroyd, Lionel Barber, Geoffrey Cannon, J. S. Oxford, Bryan Silcock Science Correspondent, George Perry, Tony Willard, Geoffrey Dicks, Brian Moynahan, Patrick Forman, John Tooley, Roger Eglin, Ann Boyd, James Tucker, Michael Nimmo, Peter Shearlock, Boris Schapiro, Sean French, Marjorie Wallace, Richard Brooks, David Hughes, Muriel Bowen Local Government Correspondent, George Rosie, Brian Jackman, Claire Tomalin, Judith Jackson, Anthony Storr, Nick Gilbert, Brian Sewell, John Barnes, Jill Neville, Eric Marsden, Peter Wilsher, Stephen Wood, Philip Reevell, Vladimir Nakaryakov (Political Analyst), Hugo Young Political Editor, Simon Freeman, Malcolm Winton, James Wilson, Hannah Charlton, M J Trimble, Mary Harris, Angela Wilkes, Stephen Jones, Hirsh Goodman, John Ruddock chairman of Cnd, Brian Deer, Martin Kettle, V. Harrison, Patrick Rowley, Ronald Butt, David Lipsey, H. G. V., Alan Budd, André Previn, Brough Scott, Richard Brooks Technology Correspondent, Deyan Sudjic, Bill Cater, Tony Osman, Brian Case, Barrie Penrose, Dudley Doust, Alison Miller, Clare Dyer, Peter Wilby, Lewis Chester, John Shirley Chief Reporter, Peter Shearlock City Editor, Mihir Bose, Peter Clarke, Godfrey Smith, Ronald Reagan, Richard Burnell, Dougie Byng, Suzanne Lowry, Charies Gans, Dr Jim Riordan, B., Rosemary, Joe lrving, Paddy French, Peter Dunn, Joan Forbes, Paul Hooper, P H Dixon Chairman, David Ford, Michael Green, Bill Robinson, M S Cuthbertson, B A McCullagh, Charles Gans, Michael Jones Political Correspondent, Robert Treep, Philip Llewellin, Linda Melvern, Marina Vaizey, Chris Lightbown, Ian Robertson, Michael Dickinson, Peter Wilby Education Correspondent, Henry Brandon Washington correspondent of Sunday Times, A P Piercy, Patience Wheatcroft, Roger Ratcliffe, Leslie Geddes-Brown, Isabel Hilton, Georgina Howell,
... A Superior Intelligence BMW TWA Selfridges Konrad Furs Zuccarelli labs. ltd Bell & Howell The Otter Payne & Gunter ...
1983 - Gale Group | Sunday Times HA GDA
Michael J. Pecaut, Paul Haerich, Cara N. Zuccarelli Miller, Anna Smith, Erik D. Zendejas, Gregory A. Nelson,
Pecaut, M. J., Haerich, P., Zuccarelli Miller, C. N., Smith, A. L., Zendejas, E. D. and Nelson, G. A. The Effects of Low-Dose, High-LET Radiation Exposure on Three Models of Behavior in C57BL/6 Mice. Radiat. Res. 162, 148–156 (2004).To investigate the behavioral consequences of exposure to whole-body irradiation such as might occur for astronauts during space flight, female C57BL/6 mice were exposed to 0, 0.1, 0.5 or 2 Gy accelerated iron ions (56Fe, Z = 26, β = 0.9, LET = 148.2 keV/μm) of 1 GeV per nucleon ...
Tópico(s): Effects of Radiation Exposure
2004 - Radiation Research Society | Radiation Research
Michael J. Pecaut, Paul Haerich, C. N. ZUCCARELLI, Adrian L. Smith, Erik D. Zendejas, Gregory A. Nelson,
Two experiments were carried out to investigate the consequences of exposure to proton radiation, such as might occur for astronauts during space flight. C57BL/6 mice were exposed, either with or without 15-g/cm2 aluminum shielding, to 0-, 3-, or 4-Gy proton irradiation mimicking features of a solar particle event. Irradiation produced transient direct deficits in open-field exploratory behavior and acoustic startle habituation. Rotorod performance at 18 rpm was impaired by exposure to proton radiation ...
Tópico(s): Traumatic Brain Injury Research
2002 - Springer Science+Business Media | Cognitive Affective & Behavioral Neuroscience
Marco Narici, Giuseppe De Vito, Martino V. Franchi, Antonio Paoli, Tatiana Moro, Giuseppe Marcolin, Bruno Grassi, Giovanni Baldassarre, Lucrezia Zuccarelli, Gianni Biolo, Filippo Giorgio Di Girolamo, Nicola Fiotti, Flemming Dela, Paul L. Greenhaff, Constantinos N. Maganaris,
Abstract The COVID‐19 pandemic is an unprecedented health crisis as entire populations have been asked to self‐isolate and live in home‐confinement for several weeks to months, which in itself represents a physiological challenge with significant health risks. This paper describes the impact of sedentarism on the human body at the level of the muscular, cardiovascular, metabolic, endocrine and nervous systems and is based on evidence from several models of inactivity, including bed rest, unilateral ...
Tópico(s): Exercise and Physiological Responses
2020 - Taylor & Francis | European Journal of Sport Science
Britton Zuccarelli, Brian Aalbers, Paul A. Grabb,
We report an unusual case of delayed bilateral, right greater than left hemiballismus in a 15-year-old female patient with a history of a craniopharyngioma 2years following the insertion of a right intratumoral chemotherapy catheter. Following cyst decompression, the catheter was found to have changed position, traversing the basal ganglia structures, namely the right subthalamic nucleus. Her movement disorder near-completely resolved immediately following removal of the catheter. A review of the ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2016 - Elsevier BV | Journal of Clinical Neuroscience
Caroline F. Wright, Nicholas M. Quaife, Laura Ramos-Hernández, Petr Danecek, Matteo P. Ferla, Kaitlin E. Samocha, Joanna Kaplanis, Eugene J. Gardner, Ruth Y. Eberhardt, Katherine R. Chao, Konrad J. Karczewski, Joannella Morales, Giuseppe Gallone, Meena Balasubramanian, Siddharth Banka, Lianne Gompertz, Bronwyn Kerr, Amelia Kirby, Sally Ann Lynch, Jenny E.V. Morton, Hailey Pinz, Francis H. Sansbury, Helen Stewart, Britton Zuccarelli, Stuart A. Cook, Jenny C. Taylor, Jane Juusola, Kyle Retterer, Helen V. Firth, Matthew E. Hurles, Enrique Lara‐Pezzi, Paul J.R. Barton, Nicola Whiffin,
Clinical genetic testing of protein-coding regions identifies a likely causative variant in only around half of developmental disorder (DD) cases. The contribution of regulatory variation in non-coding regions to rare disease, including DD, remains very poorly understood. We screened 9,858 probands from the Deciphering Developmental Disorders (DDD) study for de novo mutations in the 5' untranslated regions (5' UTRs) of genes within which variants have previously been shown to cause DD through a dominant ...
Tópico(s): Genomic variations and chromosomal abnormalities
2021 - Elsevier BV | The American Journal of Human Genetics
Alfred E. Buxton, Hugh Calkins, David J. Callans, John Dimarco, John D. Fisher, H.Leon Greene, David E. Haines, David L. Hayes, Paul A. Heidenreich, John M. Miller, Athena Poppas, Eric N. Prystowsky, Mark H. Schoenfeld, Peter Zimetbaum, David C. Goff, Frederick L. Grover, David J. Malenka, Eric D. Peterson, Martha J. Radford, Rita F. Redberg,
... Pistoia L, Gamberini M, Spasiano A, Gerardi C, Zuccarelli A, Casini T, Righi R, Missere M, Positano ... Restaino G, Borsellino Z, Caruso V, Spasiano A, Zuccarelli A, Valeri G, Toia P, Salvatori C, Positano ... Caruso V, Cuccia L, Spasiano A, Gerardi C, Zuccarelli A, D'Ascola D, Grimaldi S, Santodirocco M, ...
Tópico(s): Hemoglobinopathies and Related Disorders
2006 - Lippincott Williams & Wilkins | Circulation
Arne Melander, Jonny Olsson, Gunnar Lindberg, Alice Salzman, Timothy G. Howard, Paul Stang, Eva Lydick, Alistair Emslie‐Smith, D. I. R. Boyle, JEFF EVANS, Tamara MacDonald, Jennifer Bain, Frank Sullivan, Christian R. Juhl, Niels Pörksen, Jeppe Sturis, Malene Hollingdal, Steven M. Pincus, Johannes D. Veldhuis, A. Dejgaard, O. Schmitz, J. S. Kristensen, Kirstine Brown Frandsen, Thomas Bayer, Paul Müller, Beth E. Dunning, Sara Paladini, C. Gutierrez, Rachel Deacon, M. Valentin, George Grunberger, Wayde M. Weston, Rita Patwardhan, Elizabeth B. Rappaport, L. A. Sargeant, Nicholas J. Wareham, K.-T. Khaw, Björn Zethelius, Hans Lithell, C. N. Hales, Christian Berne, Hanna-Maaria Lakka, Laura Oksanen, T.-P. Tuomainen, Kimmo Kontula, J T Salonen, J. M. Dekker, P. de Boks, Femmie de Vegt, Coen D.A. Stehouwer, G. Nijpels, L.M. Bouter, R. J. Heine, Giovanni Bruno, P. Cavallo‐Perin, G Bargero, Nicola D’Errico, M. Borra, G. Macchia, Gianfranco Pagano, R. Newton, Danny Ruta, John P. New, Chris Wallace, M Roxburgh, R. J. Young, N. J. A. Vaughan, Perry Elliott, G. Brennan, Marion Devers, R. MacAlpine, Doug Steinke, David H. Lawson, Brigitte Decallonne, Kristina Casteels, Conny Gysemans, R. Bouillon, Chantal Mathieu, Thomas Linn, Christine Strate, Kerstin Schneider, David P. Funda, M Jirsa, Hana Kozáková, Anne Kaas, Olga Kofroňová, Helena Tlaskalová-Hogenová, Karsten Buschard, Heike Wanka, Andreas Hartmann, Beate Kuttler, S. Rasmussen, T. S. Sørensen, Helle Markholst, J. S. Petersen, Dennis G. Karounos, Thomas Dyrberg, Jon G. Mabley, György Haskó, Csaba Szabó, Jochen Seißler, T. B. T. Nguyen, Holger Steinbrenner, Werner A. Scherbaum, R Cipriani, Annarita Gabriele, M. Sensi, Leo Guidobaldi, Federico Pantellini, Maria Grazia Cerrito, Stefano Scarpa, U. Di Mario, Susanna Morano, G. Ceolotto, E. Iori, Elisabetta Baritono, S. Del Prato, Andrea Semplicini, Roberto Trevisan, Gianpaolo Zerbini, Giancarla Meregalli, Veronica Asnaghi, F. Tentori, Anna Maestroni, Ruggero Mangili, C. Marescotti, Monica Vedovato, Antonio Tiengo, J. Tadjieva, Boris Mankovsky, Sara Van Aken, Ann Raes, Johan Vande Walle, Dominique Matthys, Margarita Craen, Henrik Post Hansen, S. S. Lund, Peter Rossing, Thomas Bo Jensen, H.-H. Parving, S. Andersen, Lise Tarnow, B. V. Hansen, Christoph Trautner, Burkhard Haastert, N. Ennenbach, Stefan N. Willich, Ádám G. Tabák, T. J. Orchard, J Spranger, Klaus T. Preissner, H. Schatz, A. Pfeiffer, Alberto Palmero Canton, R Burgos, Cristina Hernández, Albert Lecube, Juan Esteban Gómez‐Mesa, Rosa Segura, Calvo Mateo, Rafael Simó, Lamia Fathallah, D. A. Greene, Irina G. Obrosova, R Gilbert, Dominique Kelly, Alison J. Cox, J. L. Berka-Wilkinson, Hugh R. Taylor, Sianna Panagiotopoulos, Vivian Lee, G. Jerums, Maria Cooper, G. A. Hitman, E Aganna, W Ogunkolade, M. Rema, R Deepa, C S Shanthirani, Khaled Barakat, Thisum R. Kumarajeewa, Paul G. Cassell, Michael McDermott, Viswanathan Mohan, Kirk Ways, Sven Bursell, Todd DeVries, James R. Woodworth, Carlos Alatorre, G. R. Gnana King, Lloyd Paul Aiello, A. E. Karisen, Dejan Pavlović, Kristina Tomra Nielsen, Jens‐Ulrik Stæhr Jensen, Henrik U. Andersen, Flemming Pociot, T. Mandrup-Poulsen, Décio L. Eizirik, J. Nerup, S Lortz, Markus Tiedge, Sigurd Lenzen, Frank Lally, Angie Bone, M. I. Darville, Ye‐Shih Ho, Johnny Sternesjö, S. Sandler, Ming‐Yin Chen, F. Schuit, Daniël Pipeleers, S. Merezak, Anandwardhan A. Hardikar, J. J. Hoet, Claude Remacle, Brigitte Reusens, B. Bréant, A. Garofano, P Czernichow, Naoto Kubota, Yasuo Terauchi, Hiroyuki Miki, Hiroyuki Tamemoto, T. Yamauchi, Reiji Nakano, Koji Komeda, Komyo Eto, Kazuyuki Tobe, S. Kimura, Takuya Kadowaki, Tatsuro Ide, Kazutoshi Murakami, Mamoru Tsunoda, T. Mochizuki, Susan E. Ozanne, B. Nave, Chung‐Li Wang, M. W. Dorling, Clive J. Petry, S.J. Koopmans, Chris van der Bent, Ivo Que, J.K. Radder, E Seböková, Aleeza Sana, I Klimeś, Neil B. Ruderman, L. Morviducci, Lisa M. Pastore, S. Morelli, Elisabetta Sagratella, D. Zorretta, A. Buongiomo, G Tamburrano, Andrea Giaccari, Sabina Martinenghi, Maria Gabriella Cusella De Angelis, F. Ravasi, Francesco Bifari, Claudio Bordignon, Luca Falqui, A Kessler, Olaf Dransfeld, Shlomo Sasson, E. Tomás, A. Zorzano, Jürgen Eckel, Per Medbøe Thorsby, A. Rosenfalck, Lise Kjems, K. F. Hanssen, Sten Madsbad, K. I. Birkeland, M. Hamilton-Wessler, J. Markussen, R. N. Bergman, V. Melki, H Hanaire-Broutin, S Bessières-Lacombe, J. Tauber, P. D. Home, Anna Lindholm Olinder, A. Riis, J Rosenstock, S. Schwartz, Christine M. Clark, Matthew Edwards, David Donley, Peter Swift, Henrik B. Mortensen, Helle Lynggaard, Philip Hougaard, C A Cull, H. A. W. Neil, V. Frighi,
Springer Science+Business Media
Karlman Wasserman, A L Van Kessel, George G. Burton,
... following a 10-day bed restGiovanni Baldassarre*, Lucrezia Zuccarelli*, Giorgio Manferdelli, Valentina Manfredini, Mauro Marzorati, Andrea Pilotto, ...
Tópico(s): Heart Rate Variability and Autonomic Control
1967 - American Physiological Society | Journal of Applied Physiology
R Margaria, H. T. Edwards, D. B. Dill,
... method during the recovery from cycle ergometer exerciseLucrezia Zuccarelli,* Paulo Cesar do Nascimento Salvador,* Alessio Del Torto, ...
Tópico(s): Exercise and Physiological Responses
1933 - American Physiological Society | American Journal of Physiology-Legacy Content
D L Wilkins, Paul Y Chung, Pam Y Tsuchiya, Izak F Wessels, Anthony J Zuccarelli,
ABSTRACT The reliability of chemical sterilizers (acetone and/or 30-percent hydrogen peroxide at 25° C and at 60° C) was tested against Bacillus subtilis inoculated onto glass slides, commercial biological indicator discs (Bacillus stearothermophilus and B. subtilis], and B. subtilis spore survival. Acetone alone was not sporicidal. Hydrogen-peroxide-sterilized glass slides were sterile after 5 minutes. The indicator discs required 25 minutes at 25" C, and less than 3 minutes at 60° C (P < .0001). The ...
Tópico(s): 3D Printing in Biomedical Research
1994 - | Ophthalmic surgery, lasers & imaging retina
Gilbert H.L. Tang, Shafie Fazel, Richard D. Weisel, Subodh Verma, Ren‐Ke Li, Eric Lim, Y Yap, Bianca De Stavola, Andrew G. Nicholson, Peter Goldstraw, Robert J. Cerfolio, Ayesha S. Bryant, Bhavana Patel, A Bartolucci, W.R. Eric Jamieson, Lawrence H. Burr, Robert T. Miyagishima, Eva Germann, Joan S. MacNab, E. H. Stanford, Fang Chan, Michael T. Janusz, Hilton Ling, Patrick McConnell, Carlos del Río, David B. Jacoby, Martina Pavlicová, Paweł Kwiatkowski, Agatha Zawadzka, Jonathan Dinsmore, Louis Astra, Sheik Wisel, Robert E. Michler, Kenton J. Zehr, Marineh Yagubyan, Heidi M. Connolly, Susan C. Nelson, Hartzell V. Schaff, R Schmitz, P Scaffa, Liugi Nardi, H Chiariello, E. W. Thornton, Carl A. Groom, B. M. Fabri, Mark Fox, Cora Hallas, Mark Jackson, Hideki Kitamura, H Okabayashi, Michiya Hanyu, Yoshiharu Soga, Takuya Nomoto, Hisashi Johno, Junko Nakano, Takehiko Matsuo, Masashi Kai, Eitaro Umehara, P Zhang, Julius M. Guccione, Susanne B. Nicholas, Joanne Walker, Pamela Crawford, Amin Shamal, David Saloner, A Wallace, Mark B. Ratcliffe, Koji Miyaji, A Murakami, Taiichi Takasaki, K Ohara, S Takamoto, Hirokuni Yoshimura, Meredith Sheil, Catherine Luxford, Michael J. Davies, Jennifer Peat, Graham R. Nunn, David S. Celermajer, Marco Ricci, Pierluca Lombardi, Alberto Galindo, A Vasquez, Jennifer E. Zuccarelli, Eliot R. Rosenkranz, Faraz Kerendi, Michael E. Halkos, Hajime Kin, Joel S. Corvera, Daniel J. Brat, Mary B. Wagner, Jakob Vinten‐Johansen, Zhi‐Qi Zhao, Joseph M. Forbess, Kirk R. Kanter, Michael J. Kelley, Paul M. Kirshbom, Aparna Hoskote, Gordon Cohen, Allan L. Goldman, Lara S. Shekerdemian, George M. Hoffman, Kathleen Mussatto, Cheryl L. Brosig, Nancy S. Ghanayem, N. Musa, Raymond T. Fedderly, Robert D.B. Jaquiss, James S. Tweddell, David Piel, Abigail Khan, Robert Waibel, Mariusz Birbach, Mitchell I. Cohen, Thomas L. Spray, Clifford S. Deutschman, J. William Gaynor, Richard J. Levy, D Schipke, Jens Litmathe, Nici Zimmermann, E. Gams, David B. MacDonald, Jie Luo, Takayuki Saito, M Duong, Pierre‐Luc Bernier, R Chiu, Dominique Shum‐Tim, Naritatsu Saito, Takeshi Kimura, Masanao Toma, Kazunari Sasaki, Toshiyuki Kita, Masato Imura, Toshihiko Saga, Kanji Inoue, Ying-Jui Lin, Chun-Wei Liang, Shen Ko, Chien-Fu Huang, J.-P Chang, Louis C. Benjamin, Jai Nahar, Craig Sable, Frank M. Midgley, G. Russo, S Sänger, I Ulrich, W Kutschka, Heyman Luckraz, S Ehsan, A R Gibbs, Eric G. Butchart, Ramiro de la Llana, Rafael Martínez‐Sanz, Francisco Díaz-Romero, Ibrahim Nassar, Pilar Garrido,
2005 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Alfred Sommer, N Shadid, P Coleridge Smith, Stavros K. Kakkos, George Lampropoulos, Spyros Papadoulas, Ioannis Ntouvas, Ioannis A. Tsolakis, Evi Kalodiki, Cevdet Adıgüzel, Omer Iqbal, George Geroulakos, M Vandendriessche, C Lebard, Christian Daniel, F Zuccarelli, J-F Uhl, M. Chahim, F Casals, D. Bernaudo, Nia Lozano, Amit Sokolov, K. V. Lyadov, M M Loutsenko, S V Lavrenko, Madeline Metcalfe, P A Gatenby, J A Reise, Jacob J. H. Franklin, Richard Chang, Jay N. Lozier, Andrew W. Kam, Enn Alexandria Chen, Thomas H. Shawker, Robert Wesley, Edie Mao, David A. Wyrick, M K Horne, Mehmet Kurtoğlu, H Ekim, D Saba, Cüneyt Köksoy, Y Akçalý, N Görmüþ, Özalp Karabay, Uğur Filizcan, E Aslým, Anıl Dolgun, M Mihmanlý, Münacettin Ceviz, Emin Alp Alayunt, Nesimi Eren, Rikke Broholm, Niels Bækgaard, Sven Just, Mette Jørgensen, Leif Panduro Jensen, Shilpa Kodati, V M Patel, J Makanjuola, Mahmoud Mobasheri, T Hussain, Robert B. McLafferty, Caroline M. Moore, DonaldW.C. Hood, Katherine Hodgson, Antonios Gasparis, N Labropoulos, P Lebda, Georgios Spentzouris, Luís León, M. Borge, Apostolos K. Tassiopoulos, Peter J. Pappas, Dragan J. Milić, Saša Živić, Dragan Bogdanović, Peter Neglén, Rikki Darcey, Seshadri Raju, H Partsch, B. Partsch, Miriam Wüst, Vinay K. Bahl, H. M. Hu, Peter K. Henke, Thomas W. Wakefield, D A Campbell, J A Caprini, A Cornu-Thénard, J.F. Uhl, Patrick Carpentier, Paul Pittaluga, S. Chastanet, Timothée Locret, Sergio Gianesini, Erica Menegatti, G Tacconi, A Palazzo, A Liboni, Paolo Zamboni, Jukka Saarinen, Anna Hjerppe, Maarit Venermo, Heini Huhtala, Annikki Vaalasti, Paolo Casoni, Olle Nelzén, Giovanni Mosti, Vincenzo Mattaliano, O. Pichot, J. Alm, Marc Vuylsteke, Jo Van Dorpe, Jennifer Roelens, Th De Bo, Serge Mordon, Lars Hvilsted Rasmussen, Martin Lawaetz, Lars Bjoern, B. Lawaetz, Allan Blemings, B Eklöf, Saulsberry Gale, J N Lee, Marianne E. Walsh, Dennis Wojnarowski, A. J. Comerota, Serafino Ricci, Ljiljana Moro, Raffaele Antonelli Incalzi, Amanda C. Shepherd, Manj Gohel, C. S. Lim, Maher Hamish, Andy Davies, A. M. van Rij, Leanne Philips, E. D. Bateman, Deng B. Madut, Torsten Kleffmann, G Jones, S Rao, Gerhard König, Steven A. Leers, J S Cho, Luke Marone, Robert Y. Rhee, Michel S. Makaroun, Rabih A. Chaer, A Thors, Patrick Muck, Manj Gohel,
Restricted accessAbstractFirst published online September 18, 2009Tenth Meeting of the European Venous Forum: Copenhagen, Denmark, 5–7 June 2009Volume 24, Issue 5https://doi.org/10.1258/phleb.2009.09a003
Tópico(s): Venous Thromboembolism Diagnosis and Management
2009 - SAGE Publishing | Phlebology The Journal of Venous Disease