Produção Nacional
Revisado por pares
Simone Zuffa, Robin Schmid, Anelize Bauermeister, Paulo Wender Portal Gomes, Andrés Mauricio Caraballo‐Rodríguez, Yasin El Abiead, Allegra T. Aron, Emily C. Gentry, Jasmine Zemlin, Michael J. Meehan, Nicole E. Avalon, Robert H. Cichewicz, Ekaterina Buzun, Marvic Carrillo Terrazas, Chia-Yun Hsu, Renee E. Oles, Adriana Vasquez Ayala, Jiaqi Zhao, Hiutung Chu, Mirte C. M. Kuijpers, Sara L. Jackrel, Fidele Tugizimana, Lerato Nephali, Ian A. Dubery, Ntakadzeni E. Madala, Eduarda Antunes Moreira, Letícia V. Costa‐Lotufo, Norberto Peporine Lopes, Paula Rezende‐Teixeira, Paula C. Jimenez, Bipin Rimal, Andrew D. Patterson, Matthew F. Traxler, Rita de Cássia Pessotti, Daniel Alvarado-Villalobos, Giselle Tamayo‐Castillo, Priscila Chaverrí, Efraín Escudero‐Leyva, Luis-Manuel Quirós-Guerrero, Alexandre Bory, Juliette Joubert, Adriano Rutz, Jean‐Luc Wolfender, Pierre‐Marie Allard, Andreas Sichert, Sammy Pontrelli, Benjamin Pullman, Nuno Bandeira, William H. Gerwick, Katia Gindro, Josep Massana‐Codina, Berenike Wagner, Karl Forchhammer, Daniel Petras, Nicole Aiosa, Neha Garg, Manuel Liebeke, Patric Bourceau, Kyo Bin Kang, Henna Gadhavi, Luiz Pedro S. de Carvalho, Mariana Silva dos Santos, Alicia Isabel Pérez‐Lorente, Carlos Molina‐Santiago, Diego Romero, Raimo Franke, Mark Brönstrup, Arturo Vera Ponce de León, Phillip B. Pope, Sabina Leanti La Rosa, Giorgia La Barbera, Henrik M. Roager, Martin Frederik Laursen, Fabian Hammerle, Bianka Siewert, Ursula Peintner, Cuauhtémoc Licona‐Cassani, Lorena Rodríguez-Orduña, Evelyn Rampler, Felina Hildebrand, Gunda Koellensperger, Harald Schoeny, Katharina Hohenwallner, Lisa Panzenboeck, Rachel Gregor, Ellis C. O’Neill, Eve Tallulah Roxborough, Jane Odoi, Nicole J. Bale, Su Ding, Jaap S. Sinninghe Damsté, Xue Li Guan, Jerry Cui, Kou‐San Ju, Denise Brentan Silva, Fernanda Motta Ribeiro Silva, Gilvan Ferreira da Silva, Héctor H. F. Koolen, Carlismari O. Grundmann, Jason A. Clement, Hosein Mohimani, Kirk Broders, Kerry L. McPhail, Sidnee E. Ober-Singleton, Christopher M. Rath, Daniel McDonald, Rob Knight, Mingxun Wang, Pieter C. Dorrestein,
Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding ...
Tópico(s): Gut microbiota and health
2024 - Nature Portfolio | Nature Microbiology
Bruno Henriques, Ana Paula C. Teixeira, Paula Figueira, Ana Teresa Reis, Joana C. Almeida, Carlos Vale, Eduarda Pereira,
This work shows the capabilities of living seaweed, Ulva lactuca, to remove As, Cd, Pb, Cu, Cr, Hg, Mn and Ni from contaminated waters. Experiments were performed with three algal doses (1.5, 3.0 and 6.0 g L−1, FW), two ionic strengths (salinity 15 and 35), and trace element concentrations corresponding to the maximum allowed values in wastewaters. The highest removals were obtained with the algal dose of 6 g L−1, with efficiencies varying between 48% for As and 98% for Hg, after 24 to 72 h. Salinity ...
Tópico(s): Fluoride Effects and Removal
2018 - Elsevier BV | The Science of The Total Environment
Ana Rita Mendes, Carlos M. Granadeiro, Andreia Leite, Eulália Pereira, Paula Teixeira, Maria de Fátima Tavares Poças,
Zinc oxide nanoparticles (ZnO NPs) have been investigated due to their distinct properties, variety of structures and sizes, and mainly for their antimicrobial activity. They have received a positive safety evaluation from the European Food Safety Authority (EFSA) for packaging applications as transparent ultraviolet (UV) light absorbers based on the absence of significant migration of zinc oxide in particulate form. ZnO NPs with different morphologies (spherical, flower, and sheet) have been synthesized ...
Tópico(s): TiO2 Photocatalysis and Solar Cells
2024 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Produção Nacional
Revisado por pares
Fábio Ribeiro Braga, Jackson Víctor de Araújo, Filippe Elias de Freitas Soares, Juliana Milani Araújo, Alexandre de Oliveira Tavela, Lorendane Millena de Carvalho, Ingrid Ney Kramer de Mello, Alessandra Teixeira de Paula, Rosane Teixeira Lelis, José Humberto de Queiróz,
Abstract The present work aimed to evaluate the production and the characterisation of a chitinase from nematophagous fungus Duddingtonia flagrans (AC001) and observe the interaction of this fungus on engorged females of Amblyomma cajennense under laboratory conditions. In assay A, the engorged females of A. cajennense were separated and immersed for 5 seconds in a fungal suspension of 106 conidia/ml of the fungus D. flagrans and placed in Petri dishes, in the dark. In assay B, wheat bran supplemented ...
Tópico(s): Pineapple and bromelain studies
2013 - Taylor & Francis | Biocontrol Science and Technology
Produção Nacional
Revisado por pares
Vicente de Paula Antunes Teixeira, Maria Betânia Mahler Araújo, Marlene Antônia dos Reis, Lucelena dos Reis, Suzana Aparecida Silveira, Maria Laura Pinto Rodrigues, João V. M. Franquini,
... cruzi myocarditis Get access Vicente de Paula Antunes Teixeira, Vicente de Paula Antunes Teixeira Disciplina de Patologia Geral, Faculdade de Medicina do ...
Tópico(s): Viral Infections and Immunology Research
1993 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene
Ana Gomes, Lucinda J. Bessa, Patrícia Correia, Iva Fernandes, Ricardo Ferraz, Paula Gameiro, Cátia Teixeira, Paula Gomes,
A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based ...
Tópico(s): Microbial Natural Products and Biosynthesis
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Ana Gomes, Lucinda J. Bessa, Iva Fernandes, Ricardo Ferraz, Nuno Mateus, Paula Gameiro, Cátia Teixeira, Paula Gomes,
Antimicrobial resistance is becoming one the most serious health threats worldwide, as it not only hampers effective treatment of infectious diseases using current antibiotics, but also dramatically increases the risks of medical procedures like surgery, transplantation, bone and dental implantation, chemotherapy, or chronic wound management. To date, there are no effective measures to tackle life-threatening nosocomial infections caused by multidrug resistant bacterial species, of which Gram-negative ...
Tópico(s): Bacterial biofilms and quorum sensing
2019 - Frontiers Media | Frontiers in Microbiology
Helena Albano, Isabel Henriques, António Correia, Tim Hogg, Paula Teixeira,
... 1111/j.1365-2672.2008.03947.xCitations: 31 Paula Teixeira, Rua Dr. António Bernardino de Almeida, 4200-072 ...
Tópico(s): Identification and Quantification in Food
2008 - Oxford University Press | Journal of Applied Microbiology
Produção Nacional
Revisado por pares
Paula Rodrigues-Pereira, Marcelle Novaes Andrade, Ana Paula Santos-Silva, Mariana Pires Teixeira, Paula Soares, Jones Bernardes Graceli, Denise Pires de Carvalho, Glaecir Roseni Mundstock Dias, Andrea Cláudia Freitas Ferreira, Leandro Miranda‐Alves,
Tributyltin (TBT) is an endocrine disruptor chemical (EDC) capable of altering the proper function of the hypothalamus-pituitary thyroid (HPT) axis. This study aimed to evaluate the subacute effects of TBT on the HPT axis of male and female rats. A dose of 100 ng/kg/day TBT was used in both sexes over a 15-day period, and the morphophysiology and gene expression of the HPT axis were assessed. TBT exposure increased the body weight in both sexes, while food efficiency increased - only in male rats. It ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2022 - Elsevier BV | Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
Produção Nacional
Revisado por pares
Omar Raimundo de Paula Teixeira Raimundo de Paula Teixeira, Carlos Ricardo Rossetto, Carlos Eduardo Carvalho,
O ajuste ao ambiente no qual estao inseridas as estrategia das organizacoes, tem sido cada vez mais considerado importante para a sobrevivencia organizacional. Esta pesquisa teve como objetivo verificar a relacao entre a incerteza ambiental percebida pelos gestores, descrita no modelo proposto por Duncan (1972), e o comportamento estrategico, conforme proposto por Miles e Snow (1978), adotado pelos Administradores de Hoteis de Florianopolis-SC, nos ultimos 5 anos. Optou-se por abordagem quantitativa ...
Tópico(s): Environmental Sustainability in Business
2009 - UNIVERSIDADE DO VALE DO ITAJAÍ | Turismo - Visão e Ação
David M. Pereira, Juliana Vinholes, Paula Guedes de Pinho, Patrı́cia Valentão, Teresa Mouga, Natércia Teixeira, Paula B. Andrade,
In this work a fast and simple multi-target gas chromatography-mass spectrometry (GC-MS) method for the simultaneous detection and absolute quantification of amino acids, fatty acids, sterols and lupanes in marine organisms is proposed. The methodology was applied to the characterization of the echinoderm Marthasterias glacialis Linnaeus spiny sea star extracts. The main factors influencing the extraction of target compounds were evaluated by using different extraction procedures, solvent systems ...
Tópico(s): Aquaculture Nutrition and Growth
2012 - Elsevier BV | Talanta
Produção Nacional
Revisado por pares
Marcelle Novaes Andrade, Ana Paula Santos-Silva, Paula Rodrigues-Pereira, Francisca Diana Paiva-Melo, Niedson Correa de Lima, Mariana Pires Teixeira, Paula Soares, Glaecir Roseni Mundstock Dias, Jones Bernardes Graceli, Denise Pires de Carvalho, Andrea Cláudia Freitas Ferreira, Leandro Miranda‐Alves,
Tributyltin is a biocide used in nautical paints, aiming to reduce fouling of barnacles in ships. Despite the fact that many effects of TBT on marine species are known, studies in mammals have been limited, especially those evaluating its effect on the function of the hypothalamus-pituitary-thyroid (HPT) axis. The aim of this study was to investigate the effects of subchronic exposure to TBT on the HPT axis in female rats. Female Wistar rats received vehicle, TBT 200 ng kg-1 BW d-1 or 1000 ng kg- ...
Tópico(s): Organometallic Compounds Synthesis and Characterization
2018 - Elsevier BV | Environmental Pollution
Teresa Bento de Carvalho, Joana Barbosa, Paula Teixeira,
The survival and spread of foodborne and nosocomial-associated bacteria through high-touch surfaces or contamination-prone sites, in either healthcare, domestic or food industry settings, are not always prevented by the employment of sanitary hygiene protocols. Antimicrobial surface coatings have emerged as a solution to eradicate pathogenic bacteria and prevent future infections and even outbreaks. Standardised antimicrobial testing methods play a crucial role in validating the effectiveness of ...
Tópico(s): Infection Control in Healthcare
2024 - Multidisciplinary Digital Publishing Institute | Biology
Produção Nacional
Revisado por pares
Ana Paula Pagano, Juliana Maria Faccioli Sicchieri, Isabela Laurencio Schiavoni, D. Barbeiro, Camila Sanches Manca, Bruna Ramos da Silva, Amanda Escobar Bezerra, Lívia Cristina Mendonça Pinto, Roberta Chaves Araújo, Andreza Corrêa Teixeira, Paula Garcia Chiarello,
The aim of this study was to evaluate the applicability of phase angle (PhA) as a severity indicator of chronic liver diseases. We examined the medical records of 54 patients—27 with hepatocellular carcinoma (HCC) and 27 with non-alcoholic fatty liver disease (NAFLD). The patients were ≥18 y of age. Clinical data, such as Child-Pugh and Barcelona Clinic Liver Cancer (HCC), aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis (FIB)-4 (NAFLD), nutritional parameters (body mass index [BMI], ...
Tópico(s): Nutrition and Health in Aging
2019 - Elsevier BV | Nutrition
Mónica Carvalheira, Catarina L. Amorim, Ana Catarina Oliveira, Eliana C. Guarda, Eunice Costa, Margarida Ribau Teixeira, Paula M. L. Castro, Anouk F. Duque, Maria A.M. Reis,
Raw brewers' spent grain (BSG), a by-product of beer production and produced at a large scale, presents a composition that has been shown to have potential as feedstock for several biological processes, such as polyhydroxyalkanoates (PHAs) production. Although the high interest in the PHA production from waste, the bioconversion of BSG into PHA using microbial mixed cultures (MMC) has not yet been explored. This study explored the feasibility to produce PHA from BSG through the enrichment of a mixed ...
Tópico(s): Microplastics and Plastic Pollution
2022 - Multidisciplinary Digital Publishing Institute | Life
Alberto A. Robles-Loaiza, Edgar A. Pinos-Tamayo, Bruno Mendes, Josselyn A. Ortega-Pila, Carolina Proaño‐Bolaños, Fabien Plisson, Cátia Teixeira, Paula Gomes, José R. Almeida,
Peptides have positively impacted the pharmaceutical industry as drugs, biomarkers, or diagnostic tools of high therapeutic value. However, only a handful have progressed to the market. Toxicity is one of the main obstacles to translating peptides into clinics. Hemolysis or hemotoxicity, the principal source of toxicity, is a natural or disease-induced event leading to the death of vital red blood cells. Initial screenings for toxicity have been widely evaluated using erythrocytes as the gold standard. ...
Tópico(s): Biochemical and Structural Characterization
2022 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Andreia Peixoto, Dylan Ferreira, Rita Azevedo, Rui Freitas, Elisabete Fernandes, Marta Relvas‐Santos, Cristiana Gaiteiro, Janine Soares, Sofia Cotton, Beatriz Teixeira, Paula Paulo, Luís Lima, Carlos Palmeira, Gabriela Martins, Maria José Oliveira, André M. N. Silva, Lúcio Lara Santos, José Alexandre Ferreira,
Muscle invasive bladder cancer (MIBC) remains amongst the deadliest genitourinary malignancies due to treatment failure and extensive molecular heterogeneity, delaying effective targeted therapeutics. Hypoxia and nutrient deprivation, oversialylation and O-glycans shortening are salient features of aggressive tumours, creating cell surface glycoproteome fingerprints with theranostics potential.A glycomics guided glycoproteomics workflow was employed to identify potentially targetable biomarkers using ...
Tópico(s): Advanced Proteomics Techniques and Applications
2021 - BioMed Central | Journal of Experimental & Clinical Cancer Research
Marco da Silva, Cátia Teixeira, Paula Gomes, Margarida Borges,
Toxoplasmosis is a parasitic disease caused by the globally distributed protozoan parasite Toxoplasma gondii, which infects around one-third of the world population. This disease may result in serious complications for fetuses, newborns, and immunocompromised individuals. Current treatment options are old, limited, and possess toxic side effects. Long treatment durations are required since the current therapeutic system lacks efficiency against T. gondii tissue cysts, promoting the establishment ...
Tópico(s): Parasitic Infections and Diagnostics
2021 - Multidisciplinary Digital Publishing Institute | Microorganisms
Ana Gomes, Luísa Aguiar, Ricardo Ferraz, Cátia Teixeira, Paula Gomes,
Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic ...
Tópico(s): Surfactants and Colloidal Systems
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Natércia Teixeira, Paula Nabais, Víctor de Freitas, João A. Lopes, Maria João Melo,
Abstract Iron-gall ink is one of the most important inks in the history of western civilization. The deep black colour results from Fe 3+ complexes with phenolic compounds available in gall extracts. Unfortunately, it induces the degradation of both ink and support over time. Furthermore, our knowledge of these complex molecular structures is limited. This work aims to overcome this gap, revealing essential information about the complex structures of these pigments and dyes that will create a breakthrough ...
Tópico(s): Archaeological Research and Protection
2021 - Nature Portfolio | Scientific Reports
Questa Karlsson, Mark N. Brook, Tokhir Dadaev, Sarah Wakerell, Edward J. Saunders, Kenneth Muir, David E. Neal, Graham G. Giles, Robert J. MacInnis, Stephen N. Thibodeau, Shannon K. McDonnell, Lisa Cannon‐Albright, Manuel R. Teixeira, Paula Paulo, Marta Cardoso, Chad D. Huff, Donghui Li, Yao Yu, Paul Scheet, Jennifer B. Permuth, Janet L. Stanford, James Y. Dai, Elaine A. Ostrander, Olivier Cussenot, Géraldine Cancel‐Tassin, Josef Hoegel, Kathleen Herkommer, Johanna Schleutker, Teuvo L.J. Tammela, Venkat Rathinakannan, Csilla Sipeky, Fredrik Wiklund, Henrik Grönberg, Markus Aly, William B. Isaacs, Joanne L. Dickinson, Liesel M. FitzGerald, Melvin L.K. Chua, Tú Nguyen‐Dumont, Daniel J. Schaid, Melissa C. Southey, Rosalind A. Eeles, Zsofia Kote‐Jarai,
Germline ATM mutations are suggested to contribute to predisposition to prostate cancer (PrCa). Previous studies have had inadequate power to estimate variant effect sizes.To precisely estimate the contribution of germline ATM mutations to PrCa risk.We analysed next-generation sequencing data from 13 PRACTICAL study groups comprising 5560 cases and 3353 controls of European ancestry.Variant Call Format files were harmonised, annotated for rare ATM variants, and classified as tier 1 (likely pathogenic) ...
Tópico(s): Genetic factors in colorectal cancer
2021 - Elsevier BV | European Urology Oncology
David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders, Xin Sheng, Alisha Chou, Fredrick R. Schumacher, Ali Amin Al Olama, Sara Benlloch, Tokhir Dadaev, Mark N. Brook, Ali Sahimi, Thomas J. Hoffmann, Atushi Takahashi, Koichi Matsuda, Yukihide Momozawa, Masashi Fujita, Kenneth Muir, Artitaya Lophatananon, Peggy Wan, Loı̈c Le Marchand, Lynne R. Wilkens, Victoria L. Stevens, Susan M. Gapstur, Brian D. Carter, Johanna Schleutker, Teuvo L.J. Tammela, Csilla Sipeky, Anssi Auvinen, Graham G. Giles, Melissa C. Southey, Robert J. MacInnis, Cezary Cybulski, Dominika Wokołorczyk, Jan Lubiński, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Richard M. Martin, Børge G. Nordestgaard, Sune F. Nielsen, Maren Weischer, Stig E. Bojesen, Martin Andreas Røder, Peter Iversen, Jyotsna Batra, Suzanne K. Chambers, Leire Moya, Lisa G. Horvath, Judith A. Clements, Wayne D. Tilley, Gail P. Risbridger, Henrik Grönberg, Markus Aly, Robert Szulkin, Martin Eklund, Tobias Nordström, Nora Pashayan, Alison M. Dunning, Maya Ghoussaini, Ruth C. Travis, Timothy J. Key, Elio Ríboli, Jong Y. Park, Thomas A. Sellers, Hui‐Yi Lin, Demetrius Albanes, Stephanie J. Weinstein, Lorelei A. Mucci, Edward L. Giovannucci, Sara Lindström, Peter Kraft, David J. Hunter, Kathryn L. Penney, Constance Turman, Catherine M. Tangen, Phyllis J. Goodman, Ian M. Thompson, Robert J. Hamilton, Neil E. Fleshner, Antonio Finelli, Marie‐Elise Parent, Janet L. Stanford, Elaine A. Ostrander, Milan S. Geybels, Stella Koutros, Laura E. Beane Freeman, Meir J. Stampfer, Alicja Wolk, Niclas Håkansson, Gerald L. Andriole, Robert N. Hoover, Mitchell J. Machiela, Karina D. Sørensen, Michael Borre, William J. Blot, Wei Zheng, Edward D. Yeboah, James E. Mensah, Yong‐Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Yudong Wu, Shan‐Chao Zhao, Zan Sun, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Catharine West, N.G. Burnet, Gill Barnett, Christiane Maier, Thomas Schnoeller, Manuel Luedeke, Adam S. Kibel, Bettina F. Drake, Olivier Cussenot, Géraldine Cancel‐Tassin, F. Ménégaux, Thérèse Truong, Yves Akoli Koudou, Esther M. John, Eli Marie Grindedal, Lovise Mæhle, Kay‐Tee Khaw, Sue A. Ingles, Mariana C. Stern, Ana Vega, Antonio Gómez‐Caamaño, Laura Fachal, Barry S. Rosenstein, Sarah L. Kerns, Harry Ostrer, Manuel R. Teixeira, Paula Paulo, Andreia Brandão, Stephen Watya, Alexander Lubwama, Jeannette T. Bensen, Elizabeth T. H. Fontham, James L. Mohler, Jack A. Taylor, Manolis Kogevinas, Javier Llorca, Gemma Castaño‐Vinyals, Lisa Cannon‐Albright, Craig C. Teerlink, Chad D. Huff, Sara S. Strom, Luc Multigner, Pascal Blanchet, Laurent Brureau, Radka Kaneva, Chavdar Slavov, Vanio Mitev, Robin J. Leach, Brandi Weaver, Hermann Brenner, Katarina Ćuk, Bernd Holleczek, Kai-Uwe Saum, Eric A. Klein, Ann W. Hsing, Rick A. Kittles, Adam B. Murphy, Christopher J. Logothetis, Jeri Kim, Susan L. Neuhausen, Linda Steele, Yuan Chun Ding, William B. Isaacs, Barbara Nemesure, Anselm Hennis, John Carpten, Hardev Pandha, Agnieszka Michael, Kim De Ruyck, Gert De Meerleer, Piet Ost, Jianfeng Xu, Azad Hassan Abdul Razack, Jasmine Lim, Soo‐Hwang Teo, Lisa F. Newcomb, Daniel Lin, Jay H. Fowke, Christine Neslund‐Dudas, Benjamin A. Rybicki, Marija Gamulin, Davor Lessel, Tomislav Kuliš, Nawaid Usmani, Sandeep K. Singhal, Matthew Parliament, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Manuela Gago‐Dominguez, Jose E. Castelao, Marı́a Elena Martı́nez, Samantha Larkin, Paul A. Townsend, Claire Aukim-Hastie, William S. Bush, Melinda C. Aldrich, Dana C. Crawford, Shiv Srivastava, Jennifer Cullen, György Petrovics, Graham Casey, Monique J. Roobol, Guido Jenster, Ron H. N. van Schaik, Jennifer J. Hu, Maureen Sanderson, Rohit Varma, Roberta McKean‐Cowdin, Mina Torres, Nicholas Mancuso, Sonja I. Berndt, Stephen K. Van Den Eeden, Douglas F. Easton, Stephen J. Chanock, Michael B. Cook, Fredrik Wiklund, Hidewaki Nakagawa, Esther M. John, Rosalind A. Eeles, Zsofia Kote‐Jarai, Christopher A. Haiman,
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval ( ...
Tópico(s): Prostate Cancer Treatment and Research
2021 - Nature Portfolio | Nature Genetics
Rafael J. Mendes, Laura Regalado, J.P. Luz, Natália Tassi, Cátia Teixeira, Paula Gomes, Fernando Tavares, Conceição Santos,
Fire blight is a major pome fruit trees disease that is caused by the quarantine phytopathogenic Erwinia amylovora, leading to major losses, namely, in pear and apple productions. Nevertheless, no effective sustainable control treatments and measures have yet been disclosed. In that regard, antimicrobial peptides (AMPs) have been proposed as an alternative biomolecule against pathogens but some of those AMPs have yet to be tested against E. amylovora. In this study, the potential of five AMPs (RW- ...
Tópico(s): Plant-Microbe Interactions and Immunity
2021 - Multidisciplinary Digital Publishing Institute | Biomolecules
Diana R. Fonseca, Ana Moura, Victoria Leiro, Ricardo Silva-Carvalho, Berta N. Estevinho, Catarina Leal Seabra, Patrícia C. Henriques, Mónica Lucena, Cátia Teixeira, Paula Gomes, Paula Parreira, M. Cristina L. Martins,
MSI-78A (Pexiganan A) is one of the few antimicrobial peptides (AMPs) able to kill Helicobacter pylori, a pathogenic bacterium that colonizes the gastric mucosa of half of the world's population. Antibiotics fail in 20–40% of H. pylori-infected patients, reinforcing the need for alternative treatments. Herein, a bioengineered approach was developed. MSI-78A with a C-terminal cysteine was grafted onto chitosan microspheres (AMP-ChMic) by thiol-maleimide (Michael-addition) chemistry using a long heterobifunctional ...
Tópico(s): Probiotics and Fermented Foods
2021 - Elsevier BV | Acta Biomaterialia
Produção Nacional
Giovani Giroto, Ercília Maria Ângeli Teixeira de Paula,
No Brasil, imigrantes e refugiados têm encontrado dificuldades quanto a garantia dos seus direitos, dentre esses, o direito a educação básica e ao ensino superior. O objetivo geral deste artigo foi analisar as características da educação formal dos imigrantes e refugiados no Brasil, da educação básica ao ensino superior. Os objetivos específicos foram apresentar uma revisão de literatura da produção acadêmica a respeito da escolarização das crianças imigrantes no Brasil e discutir resoluções que ...
Tópico(s): Migration, Racism, and Human Rights
2020 - UNIVERSIDADE FEDERAL DA PARAÍBA | Revista Espaço do Currículo
Produção Nacional
Revisado por pares
Camilo Geraldo de Souza Teixeira, Paula Volpato Sanitá, Ana Paula Dias Ribeiro, Luana Mendonça Dias, Janaína Habib Jorge, Ana Cláudia Pavarina,
Staphylococcus aureus have a great ability to become rapidly resistant to conventional antimicrobial therapies. This study evaluated the efficacy of antimicrobial photodynamic therapy (aPDT) mediated by Curcumin (Cur) and light-emitting diode (LED) in the inactivation of biofilms of methicillin susceptible and resistant S. aureus (MSSA and MRSA, respectively). Biofilms were treated with Cur (20, 40 or 80 μM) and illuminated with LED source (455 ± 3 nm; 5.28 J/cm2) (aPDT groups), or treated either with Cur ...
Tópico(s): Antimicrobial Peptides and Activities
2020 - Elsevier BV | Photodiagnosis and Photodynamic Therapy
Minh‐Phuong Huynh‐Le, Chun Fan, Roshan Karunamuni, Eleanor Walsh, Emma L. Turner, J. Athene Lane, Richard M. Martin, David E. Neal, Jenny Donovan, Freddie C. Hamdy, J. Kellogg Parsons, Rosalind A. Eeles, Douglas F. Easton, Zsofia Kote‐Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, Kenneth Muir, Henrik Grönberg, Fredrik Wiklund, Markus Aly, Johanna Schleutker, Csilla Sipeky, Teuvo L.J. Tammela, Børge G. Nordestgaard, Timothy J. Key, Ruth C. Travis, Paul D.P. Pharoah, Nora Pashayan, Kay‐Tee Khaw, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S. Kibel, Cezary Cybulski, Dominika Wokołorczyk, Wojciech Kluźniak, Lisa Cannon‐Albright, Hermann Brenner, Ben Schöttker, Bernd Holleczek, Jong Y. Park, Thomas A. Sellers, Hui‐Yi Lin, Chavdar Kroumov Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Judith A. Clements, Amanda B. Spurdle, Manuel R. Teixeira, Paula Paulo, Sofia Maia, Hardev Pandha, Agnieszka Michael, Ian G. Mills, Ole A. Andreassen, Anders M. Dale, Tyler M. Seibert,
A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. Here, we assess the potential impact of PHS-informed screening.
Tópico(s): Colorectal Cancer Screening and Detection
2020 - American Association for Cancer Research | Cancer Epidemiology Biomarkers & Prevention
Produção Nacional
Revisado por pares
Ednéia Corrêa de Mello, Simone Cecílio Hallak Regalo, Luanna Honorato Diniz, Janaine Brandão Lage, Mariane Fernandes Ribeiro, Domingos Emanuel Bevilacqua, Rodrigo César Rosa, Alex Abadio Ferreira, Mara Lúcia Fonseca Ferraz, Vicente de Paula Antunes Teixeira, Ana Paula Espíndula,
The aging process affects the entire human body, including the stomatognathic system, and can trigger not only occlusal but also postural imbalances involving other muscular chains. Hippotherapy has been used to promote cervical, postural, and balance control in individuals with diverse impairments. The present study used electromyography to evaluate the masseter and temporal muscles in an elderly population pre- and post-hippotherapy. Participants included 17 individuals, mean age 66,5±7 years. ...
Tópico(s): Voice and Speech Disorders
2020 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Luanna Honorato Diniz, Ednéia Corrêa de Mello, Mariane Fernandes Ribeiro, Janaine Brandão Lage, Domingos Emanuel Bevilacqua, Alex Abadio Ferreira, Mara Lúcia da Fonseca Ferraz, Rodrigo César Rosa, Vicente de Paula Antunes Teixeira, Ana Paula Espíndula,
Introduction The decrease in functional ability, strength, balance, flexibility, agility, and coordination owing to neurological and muscular changes is one of the characteristic features of the human aging process. Hippotherapy has been highlighted as a therapeutic approach with physical and psychological benefits for this section of the population. However, the effects of hippotherapy in elderly people need to be further studied by assessing their balance and flexibility. Methods Thirty elderly ...
Tópico(s): Effects of Vibration on Health
2019 - Elsevier BV | Journal of Bodywork and Movement Therapies
Ana Teresa Silva, Maria João Cerqueira, Cristina Prudêncio, Maria Helena Fernandes, João Costa‐Rodrigues, Cátia Teixeira, Paula Gomes, Ricardo Ferraz,
In the last few years, we have been witnessing an increasing interest in ionic liquids (ILs) and organic salts, given their potential applications in biological and pharmaceutical sciences. We report the synthesis and in vitro evaluation of novel organic salts combining betulinate, known for its anticancer properties, with antimalarial drugs, primaquine, chloroquine, and mepacrine, and also with the trihexyltetradecylphosphonium ([P6,6,6,14]) cation. The salts were screened for their in vitro activity ...
Tópico(s): Essential Oils and Antimicrobial Activity
2019 - American Chemical Society | ACS Omega