J Mocco, Corbett Shelton, Paulina Sergot, Andrew F. Ducruet, Ricardo J. Komotar, Marc L. Otten, Sergei A. Sosunov, Robert B. MacArthur, Thomas P. Kennedy, E. Sander Connolly,
OBJECTIVE Inflammatory cascades play a significant role in progressive neurological injury after transient cerebral ischemia. It has been demonstrated that heparin, a potent anticoagulant, also possesses anti-inflammatory properties that diminish postreperfusion damage after stroke. However, the potential for heparin to induce hemorrhagic transformation of an infarct has deterred its use in cases of focal cerebral ischemia. In this study, we examined whether or not administration of a novel O-desulfated ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2007 - Lippincott Williams & Wilkins | Neurosurgery
Andrew F. Ducruet, Brad E. Zacharia, Sergey A. Sosunov, Paul R. Gigante, Mason L. Yeh, J Górski, Marc L. Otten, Richard Y. Hwang, Peter DeRosa, Zachary L. Hickman, Paulina Sergot, E. Sander Connolly,
Background and Purpose The restoration of blood-flow following cerebral ischemia incites a series of deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition of the C3a-receptor ameliorates cerebral injury by attenuating post-ischemic inflammation. Recent reports also implicate C3a in the modulation of tissue repair, suggesting that complement may influence both injury and recovery at later post-ischemic time-points. Methods To evaluate the effect of C3a-receptor antagonism ...
Tópico(s): Neurological Complications and Syndromes
2012 - Public Library of Science | PLoS ONE