Produção Nacional
Revisado por pares
Melina Mottin, Paulo C. T. Souza, Munir S. Skaf,
The peroxisome proliferator-activated receptor γ (PPARγ) is an important transcription factor that plays a major role in the regulation of glucose and lipid metabolisms and has, therefore, many implications in modern-life metabolic disorders such as diabetes, obesity, and cardiovascular diseases. Phosphorylation of PPARγ by the cyclin-dependent kinase 5 (Cdk5) has been recently proved to promote obesity and loss of insulin sensitivity. The inhibition of this reaction is currently being pursued to ...
Tópico(s): Protein Structure and Dynamics
2015 - American Chemical Society | The Journal of Physical Chemistry B
Produção Nacional
Revisado por pares
Leandro N. Zanotto, Gabriel Heerdt, Paulo C. T. Souza, Guido Araújo, Munir S. Skaf,
Since the commercial introduction of Ion Mobility coupled with Mass Spectrometry (IM‐MS) devices in 2003, a large number of research laboratories have embraced the technique. IM‐MS is a fairly rapid experiment used as a molecular separation tool and to obtain structural information. The interpretation of IM‐MS data is still challenging and relies heavily on theoretical calculations of the molecule's collision cross section (CCS) against a buffer gas. Here, a new software ( HPCCS ) is presented, which ...
Tópico(s): Analytical chemistry methods development
2018 - Wiley | Journal of Computational Chemistry
... USP), Alexandre Braga da Rocha (UFRJ), Munir Salomão Skaf (Unicamp), Paulo Augusto Netz (UFRGS), Regiane de Cássia Maritan Ugulino ...
Tópico(s): Various Chemistry Research Topics
2010 - Wiley | International Journal of Quantum Chemistry
Produção Nacional
Gabriel Heerdt, Leandro N. Zanotto, Paulo C. T. Souza, Guido Araújo, Munir S. Skaf,
A technical overview of the High Performance Collision Cross Section (HPCCS) software for accurate and efficient calculations of collision cross sections for molecular ions ranging from small organic molecules to large protein complexes is presented. The program uses helium or nitrogen as buffer gas with considerable gains in computer time compared to publicly available codes under the Trajectory Method approximation. HPCCS is freely available under the Academic Use License at https://github.com/ ...
Tópico(s): Pesticide Residue Analysis and Safety
2019 - Springer Science+Business Media | Methods in molecular biology
Produção Nacional
Revisado por pares
Melina Mottin, Paulo C. T. Souza, Clarisse G. Ricci, Munir S. Skaf,
The peroxisome proliferator-activated receptor γ (PPARγ) ligands are important therapeutic drugs for the treatment of type 2 diabetes, obesity and cardiovascular diseases. In particular, partial agonists and non-agonists are interesting targets to reduce glucose levels, presenting few side effects in comparison to full agonists. In this work, we present a set of CHARMM-based parameters of a molecular mechanics force field for two PPARγ ligands, GQ16 and SR1664. GQ16 belongs to the thiazolidinedione ...
Tópico(s): Adipose Tissue and Metabolism
2016 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Anders Hansson, Paulo C. T. Souza, Rodrigo L. Silveira, Leandro Martı́nez, Munir S. Skaf,
Abstract We develop a CHARMM‐based interaction potential for rosiglitazone, a well‐known selective ligand to the γ isoform of the peroxisome proliferator‐activated receptor (PPARγ) and widely marketed antidiabetic drug of the thiazolidinedione (TZD) class. We derive partial atomic charges and dihedral torsion potentials for seven rotations in the molecule, for which there are no analogs available in CHARMM. The potential model is validated by performing a series of molecular dynamics simulations of ...
Tópico(s): Lipid Membrane Structure and Behavior
2010 - Wiley | International Journal of Quantum Chemistry
Produção Nacional
Revisado por pares
Érica T. Prates, Paulo C. T. Souza, Mónica Pickholz, Munir S. Skaf,
Abstract We present a set of CHARMM‐based parameters of molecular mechanics force field for neutral articaine (ATC), a potent and widely used local anesthetic in medical and dental applications. Partial atomic charges and effective torsion potentials around four chemical bonds, not available in CHARMM for this molecule, were obtained from quantum chemical calculations. The newly parameterized model was evaluated by examining the behavior of ATC in water and in a phospholipid bilayer using molecular ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2010 - Wiley | International Journal of Quantum Chemistry
Produção Nacional
Revisado por pares
Ana Carolina Migliorini Figueira, Daniel M. Saidemberg, Paulo C. T. Souza, Leandro Martı́nez, Thomas S. Scanlan, John D. Baxter, Munir S. Skaf, Mário Sérgio Palma, Paul Webb, Igor Polikarpov,
Thyroid hormone receptors (TRs) are ligand-gated transcription factors with critical roles in development and metabolism. Although x-ray structures of TR ligand-binding domains (LBDs) with agonists are available, comparable structures without ligand (apo-TR) or with antagonists are not. It remains important to understand apo-LBD conformation and the way that it rearranges with ligands to develop better TR pharmaceuticals. In this study, we conducted hydrogen/deuterium exchange on TR LBDs with or without ...
Tópico(s): Thyroid Disorders and Treatments
2010 - Oxford University Press | Molecular Endocrinology
Produção Nacional
Revisado por pares
Paulo C. T. Souza, Larissa C. Textor, Denise C. Melo, Alessandro S. Nascimento, Munir S. Skaf, Igor Polikarpov,
The natural ligand 17β-estradiol (E2) is so far believed to induce a unique agonist-bound active conformation in the ligand binding domain (LBD) of the estrogen receptors (ERs). Both subtypes, ERα and ERβ, are transcriptionally activated in the presence of E2 with ERβ being somewhat less active than ERα under similar conditions. The molecular bases for this intriguing behavior are mainly attributed to subtype differences in the amino-terminal domain of these receptors. However, structural details that ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2017 - Nature Portfolio | Scientific Reports
Mirian Skaf, Daniel Sánchez Di Martino, Paulo Augusto de Arruda Mello, Rohit Varma,
Purpose To determine if genes can be transferred to fibroblasts in the filtering bleb using adenoviral vectors. Materials and Methods Twelve New Zealand albino rabbits underwent bilateral full-thickness sclerostomies. On postoperative day 1 an adenoviral vector carrying a reporter gene (lacZ) was injected into the right-eye bleb and saline was injected into the left eye bleb of each rabbit. Three rabbits were euthanized on each of the after days (days 3, 7, 14, and 21). The eyes were enucleated and ...
Tópico(s): Retinal and Macular Surgery
2001 - Lippincott Williams & Wilkins | Journal of Glaucoma
Produção Nacional
Revisado por pares
Lucas Bleicher, Ricardo Aparício, F.M. Nunes, Leandro Martı́nez, Sandra Martha Gomes Dias, Ana Carolina Migliorini Figueira, Maria A.M. Santos, Walter H Venturelli, Rosângela da Silva, Paulo Marcos Donate, Francisco AR Neves, Luiz Alberto Simeoni, John D. Baxter, Paul Webb, Munir S. Skaf, Igor Polikarpov,
Abstract Background Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Therefore, β-selective thyromimetics have been developed as promising drug-candidates for treatment of obesity and elevated cholesterol level. GC-1 [3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)-phenoxy ...
Tópico(s): Hormonal Regulation and Hypertension
2008 - BioMed Central | BMC Structural Biology
Produção Nacional
Revisado por pares
Mirian Skaf, Paulo Augusto de Arruda Mello, Rubens Belfort,
Ação dos colírios de timolol a o,5% e betaxolol a o,5% sobre a concentração protéica do humor aquoso pela laser "flare" fotometria em olhos normais e com glaucoma crônico simples Effe cts of timolol 0.5% and
Tópico(s): Retinal Development and Disorders
1995 - Conselho Brasileiro de Oftalmologia | Arquivos Brasileiros de Oftalmologia
Produção Nacional
Revisado por pares
Mirian Skaf, Paulo Augusto de Arruda Mello, José Carlos Reys, Cristina Muccioli, Rubens Belfort,
A variação do flate foi estudada antes e 2 horas após a instilação de 1 gota de timolol 0,5%, pilocarpina 2% e betaxolol 0,5% em 26 voluntários, pela laser flare fo tometria.Pilocarpina e timolol aumentaram as medidas do flare em média 143,1• % e 81,6% acima dos valores inic iais, respectiva mente para o primeiro grupo estudado (6 voluntários, 12 olhos).A diferen ça fo i estatisticamente significante (P<0,05).Timolol e betaxolol aumentaram o flare respectivamente em 78,2% e 33,2% acima das leituras ...
Tópico(s): Glaucoma and retinal disorders
1994 - Conselho Brasileiro de Oftalmologia | Arquivos Brasileiros de Oftalmologia
Produção Nacional
Revisado por pares
Susan E. Jorge, Ariel A. Petruk, Elza Kimura, Denise M. Oliveira, Lucas Caire da Silva, C.N. Suemasu, Paulo Augusto Achucarro Silveira, Dulcinéia Martins de Albuquerque, Fernando Ferreira Costa, Munir S. Skaf, Leandro Martı́nez, María de Fátima Sonati,
Hb S-São Paulo (SP) [HBB:c.20A > T p.Glu6Val; c.196A > G p.Lys65Glu] is a new double-mutant hemoglobin that was found in heterozygosis in an 18-month-old Brazilian male with moderate anemia. It behaves like Hb S in acid electrophoresis, isoelectric focusing and solubility testing but shows different behavior in alkaline electrophoresis, cation-exchange HPLC and RP-HPLC. The variant is slightly unstable, showed reduced oxygen affinity and also appeared to form polymers more stable than the Hb S. Molecular ...
Tópico(s): Iron Metabolism and Disorders
2012 - Elsevier BV | Archives of Biochemistry and Biophysics
Produção Nacional
Revisado por pares
Angélica Amorim Amato, Senapathy Rajagopalan, Jean Z. Lin, Bruno M. Carvalho, Ana Carolina Migliorini Figueira, Jenny Ying-Lin Lu, Stephen D. Ayers, Melina Mottin, Rodrigo L. Silveira, Paulo C. T. Souza, Rosa Helena Veras Mourão, Mário J. A. Saad, Marie Togashi, Luiz Alberto Simeoni, Dulcinéia Saes Parra Abdalla, Munir S. Skaf, Igor Polikparpov, Maria do Carmo Alves de Lima, Suely Lins Galdino, Richard G. Brennan, John D. Baxter, Ivan da Rocha Pitta, Paul Webb, Kevin J. Phillips, Francisco de Assis Rocha Neves,
The recent discovery that peroxisome proliferator-activated receptor γ (PPARγ) targeted anti-diabetic drugs function by inhibiting Cdk5-mediated phosphorylation of the receptor has provided a new viewpoint to evaluate and perhaps develop improved insulin-sensitizing agents. Herein we report the development of a novel thiazolidinedione that retains similar anti-diabetic efficacy as rosiglitazone in mice yet does not elicit weight gain or edema, common side effects associated with full PPARγ activation. ...
Tópico(s): Adipose Tissue and Metabolism
2012 - Elsevier BV | Journal of Biological Chemistry
Produção Nacional
Revisado por pares
Paulo C. T. Souza, Ana C. Puhl, Leandro Martı́nez, Ricardo Aparício, Alessandro S. Nascimento, Ana Carolina Migliorini Figueira, Phuong Nguyen, Paul Webb, Munir S. Skaf, Igor Polikarpov,
Abstract Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily of ligand-activated transcription factors involved in cell differentiation, growth, and homeostasis. Although X-ray structures of many nuclear receptor ligand-binding domains (LBDs) reveal that the ligand binds within the hydrophobic core of the ligand-binding pocket, a few studies suggest the possibility of ligands binding to other sites. Here, we report a new x-ray crystallographic structure of TR-LBD that shows ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2014 - Oxford University Press | Molecular Endocrinology
Produção Nacional
Revisado por pares
Paulo C. T. Souza, Gustavo Barcelos Barra, Lara Franciele Ribeiro Velasco, Isabel C.J. Ribeiro, Luiz Alberto Simeoni, Marie Togashi, Paul Webb, Francisco de Assis Rocha Neves, Munir S. Skaf, Leandro Martı́nez, Igor Polikarpov,
Nuclear hormone receptors (NRs) form a family of transcription factors that mediate cellular responses initiated by hormone binding. It is generally recognized that the structure and dynamics of the C-terminal helix 12 (H12) of NRs' ligand binding domain (LBD) are fundamental to the recognition of coactivators and corepressors that modulate receptor function. Here we study the role of three mutations in the I280 residue of H12 of thyroid hormone receptors using site-directed mutagenesis, functional ...
Tópico(s): Hypothalamic control of reproductive hormones
2011 - Elsevier BV | Journal of Molecular Biology
Produção Nacional
Revisado por pares
Amanda Bernardes, Paulo C. T. Souza, J.R.C. Muniz, Clarisse Gravina Ricci, Stephen D. Ayers, Nili Parekh, André S. Godoy, Daniela Barretto Barbosa Trivella, Peter S. Reinach, Paul Webb, Munir S. Skaf, Igor Polikarpov,
Peroxisome proliferator-activated receptors (PPARs) are members of a superfamily of nuclear transcription factors. They are involved in mediating numerous physiological effects in humans, including glucose and lipid metabolism. PPARα ligands effectively treat dyslipidemia and have significant antiinflammatory and anti-atherosclerotic activities. These effects and their ligand-dependent activity make nuclear receptors obvious targets for drug design. Here, we present the structure of the human PPARα ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2013 - Elsevier BV | Journal of Molecular Biology
Produção Nacional
Revisado por pares
M.V. Liberato, Alessandro S. Nascimento, Steven D. Ayers, Jean Z. Lin, Aleksandra Čvoro, Rodrigo L. Silveira, Leandro Martı́nez, Paulo C. T. Souza, Daniel M. Saidemberg, Tuo Deng, Angela Angelica Amato, Marie Togashi, Willa A. Hsueh, Kevin J. Phillips, Mário Sérgio Palma, Francisco de Assis Rocha Neves, Munir S. Skaf, Paul Webb, Igor Polikarpov,
Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators with improved clinical profiles are needed. We obtained a crystal structure of PPARγ ligand binding domain (LBD) and found that the ligand binding pocket (LBP) is occupied by bacterial medium chain fatty acids (MCFAs). We verified that MCFAs (C8–C10) bind the PPARγ LBD in vitro and showed ...
Tópico(s): Cancer-related gene regulation
2012 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Leandro Martı́nez, Paulo C. T. Souza, Wanius García, Fernanda Aparecida Heleno Batista, Rodrigo V. Portugal, Alessandro S. Nascimento, Marcel Nakahira, Luís Maurício T. R. Lima, Igor Polikarpov, Munir S. Skaf,
The ligand binding domain (LBD) of nuclear hormone receptors adopts a very compact, mostly alpha-helical structure that binds specific ligands with very high affinity. We use circular dichroism spectroscopy and high-temperature molecular dynamics simulations to investigate unfolding of the LBDs of thyroid hormone receptors (TRs). A molecular description of the denaturation mechanisms is obtained by molecular dynamics simulations of the TRalpha and TRbeta LBDs in the absence and in the presence of ...
Tópico(s): Molecular spectroscopy and chirality
2009 - American Chemical Society | The Journal of Physical Chemistry B
Produção Nacional
Revisado por pares
Marina Pereira Colella, Erich Vinícius De Paula, Nicola Conran, João Agostinho Machado‐Neto, Joyce Maria Annicchino-Bizzacchi, Fernando Ferreira Costa, S. T. O. Saad, Fabı́ola Traina,
... 5Stein P.D. Beemath A. Meyers F.A. Skaf E. Olson R.E. Deep venous thrombosis and ... de Amparo à Pesquisa do Estado de São Paulo (FAPESP), and INCT do Sangue. Table S1. Clinical ...
Tópico(s): Iron Metabolism and Disorders
2012 - Elsevier BV | Journal of Thrombosis and Haemostasis
G. Aad, B. Abbott, K. Abeling, Nils Julius Abicht, S. H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, C. Adam Bourdarios, L. Adamczyk, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adiguzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, I. Aizenberg, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, Nilima Nilesh Akolkar, S. Aktas, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, Guillaume Lucas Albouy, S. Alderweireldt, Z. L. Alegria, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, Samuel William Alibocus, K. Lie, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, M. Alvarez Estevez, A. Álvarez Fernández, M. Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. E. Ferreira de Lima, S. P. Amor Dos Santos, K. R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, F. F. An, M. Aoki, T. Aoki, J. A. Aparisi Pozo, M. A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S. J. Arbiol Val, C. Arcangeletti, A. T. H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N. Asbah, K. Assamagan, R. Astalos, S. Atashi, M. Atkinson, M. Atkinson, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, Filip Backman, A. Badea, T. M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, A. J. Bailey, V. R. Bailey, J. T. Baines, J. T. Baines, O. K. Baker, E. Bakos, D. Bakshi Gupta, V. Balakrishnan, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, E. Banaś, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, M. Z. Barel, K. N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baroň, P. Baroň, A. Baroncelli, G. Barone, A. J. Barr, J. D. Barr, F. Barreiro, F. Barreiro, U. Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M. J. Basso, C. R. Basson, R. L. Bates, S. Batlamous, J.R. Batley, B. Batool, M. Battaglia, D. Battulga, M. Bauce, Michael Bauer, P. Bauer, L. T. Bazzano Hurrell, J. B. Beacham, T. Beau, T. Beau, P. H. Beauchemin, P. Bechtle, H. P. Beck, H. P. Beck, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F. U. Bernlochner, F. Bernon, A. Berrocal Guardia, T. Berry, P. Berta, A. Berthold, I. A. Bertram, S. Bethke, A. Betti, A. J. Bevan, N. K. Bhalla, M. Bhamjee, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, K. D. Bhide, V. S. Bhopatkar, R. M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C. S. Billingsley, M. Bindi, A. Bingül, C. Bini, A. Biondini, C. J. Birch-sykes, G. A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J. P. Biswal, D. Biswas, K. Bjørke, I. Bloch, A. Blue, Ulrike Blumenschein, Julian Blumenthal, G. J. Bobbink, V. S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, А. Г. Богданчиков, C. Bohm, V. Boisvert, P. Bokan, T. Bołd, M. Bomben, M. Bóna, M. Boonekamp, C. D. Booth, A. G. Borbély, Iurii Bordulev, H. M. Borecka-Bielska, G. Borissov, D. Bortoletto,
Entanglement is a key feature of quantum mechanics
Nature Portfolio
G. Aad, B. Abbott, K. Abeling, Nils Julius Abicht, S. H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, C. Adam Bourdarios, L. Adamczyk, L. Adámek, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adıgüzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, I. Aizenberg, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, Nilima Nilesh Akolkar, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, Guillaume Lucas Albouy, S. Alderweireldt, M. Aleksa, Igor Alexandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, Samuel William Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, M. Alvarez Estevez, A. Álvarez Fernández, M. Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. Amidei, S. P. Amor Dos Santos, K. R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, J. A. Aparisi Pozo, M. A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, N. Aranzabal, C. Arcangeletti, A. T. H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, J. Assahsah, K. Assamagan, R. Astalos, S. Atashi, M. Atkinson, M. Atkinson, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, P. Bagnaia, M. Bahmani, A. J. Bailey, V. R. Bailey, J. T. Baines, L. Baines, C. Bakalis, O. K. Baker, E. Bakos, D. Bakshi Gupta, Veena Balakrishnan, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, E. Banaś, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, Marawan Barakat, E. L. Barberio, D. Barberis, M. Barbero, Marten Zefanja Barel, K. N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baroň, D. A. Baron Moreno, A. Baroncelli, G. Barone, A. J. Barr, Jackson Barr, L. Barranco Navarro, F. Barreiro, J. Barreiro Guimarães da Costa, Uriel Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartoš, A. Basan, M. Baselga, A. Bassalat, M. J. Basso, C. R. Basson, R. L. Bates, S. Batlamous, Richard Batley, B. Batool, M. Battaglia, D. Battulga, M. Bauce, Michael Bauer, P. Bauer, L. T. Bazzano Hurrell, J. B. Beacham, T. Beau, P. H. Beauchemin, F. Becherer, P. Bechtle, H. P. Beck, K. Becker, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F. U. Bernlochner, F. Bernon, T. Berry, P. Berta, A. Berthold, I. A. Bertram, S. Bethke, A. Betti, A. J. Bevan, Naman Kumar Bhalla, M. Bhamjee, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, V. Bhopatkar, R. Bi, R. M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, M. Bindi, A. Bingül, C. Bini, A. Biondini, C. J. Birch-sykes, G. A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J. P. Biswal, D. Biswas, A. Bitadze, K. Bjørke, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, J. Blumenthal, G. J. Bobbink, V. S. Bobrovnikov, G. J. Bobbink, B. Boehm, D. Bogavac, A. G. Bogdanchikov, C. Böhm, V. Boisvert, P. Bokan, T. Bołd, M. Bomben, M. Bóna, M. Boonekamp, C. D. Booth, A. G. Borbély, Iurii Bordulev,
The first evidence for the Higgs boson decay to a Z boson and a photon is presented, with a statistical significance of 3.4 standard deviations. The result is derived from a combined analysis of the searches performed by the ATLAS and CMS Collaborations with proton-proton collision datasets collected at the CERN Large Hadron Collider (LHC) from 2015 to 2018. These correspond to integrated luminosities of around 140 fb − 1 for each experiment, at a center-of-mass energy of 13 TeV. The measured signal ...
American Physical Society
G. Aad, B. Abbott, K. Abeling, Nils Julius Abicht, S. H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, A. C. Abusleme Hoffman, B. S. Acharya, C. Adam Bourdarios, L. Adamczyk, L. Adámek, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adıgüzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, I. Aizenberg, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, Nilima Nilesh Akolkar, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, Guillaume Lucas Albouy, S. Alderweireldt, M. Aleksa, Igor Alexandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, Samuel William Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, M. Alvarez Estevez, A. Álvarez Fernández, M. Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. Amidei, S. P. Amor Dos Santos, K. R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, J. A. Aparisi Pozo, M. A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, N. Aranzabal, C. Arcangeletti, A. T. H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, J. Assahsah, K. Assamagan, R. Astalos, S. Atashi, M. Atkinson, M. Atkinson, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, P. Bagnaia, M. Bahmani, A. J. Bailey, V. R. Bailey, J. T. Baines, J. T. Baines, C. Bakalis, O. K. Baker, E. Bakos, D. Bakshi Gupta, Veena Balakrishnan, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, E. Banaś, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, K. N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baroň, D. A. Baron Moreno, A. Baroncelli, G. Barone, A. J. Barr, Jackson Barr, L. Barranco Navarro, F. Barreiro, F. Barreiro, U. Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartoš, A. Basan, M. Baselga, A. Bassalat, M. J. Basso, C. R. Basson, R. L. Bates, S. Batlamous, Richard Batley, B. Batool, M. Battaglia, D. Battulga, M. Bauce, Michael Bauer, P. Bauer, L. T. Bazzano Hurrell, J. B. Beacham, T. Beau, P. H. Beauchemin, F. Becherer, P. Bechtle, H. P. Beck, K. Becker, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, N. L. Belyaev, D. Benchekroun, F. Bendebba, Y. Benhammou, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F. U. Bernlochner, F. Bernon, T. Berry, P. Berta, A. Berthold, I. A. Bertram, S. Bethke, A. Betti, A. J. Bevan, M. Bhamjee, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, V. Bhopatkar, R. Bi, R. M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, T. R. V. Billoud, M. Bindi, A. Bingül, C. Bini, A. Biondini, C. J. Birch-sykes, G. A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J. P. Biswal, D. Biswas, A. Bitadze, K. Bjørke, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, J. Blumenthal, G. J. Bobbink, V. S. Bobrovnikov, G. J. Bobbink, B. Boehm, D. Bogavac, A. G. Bogdanchikov, C. Böhm, V. Boisvert, P. Bokan, T. Bołd, M. Bomben, M. Bóna, M. Boonekamp, C. D. Booth, A. G. Borbély,
Searches for new resonances are performed using an unsupervised anomaly-detection technique. Events with at least one electron or muon are selected from 140 fb − 1 of p p collisions at s = 13 TeV recorded by ATLAS at the Large Hadron Collider. The approach involves training an autoencoder on data, and subsequently defining anomalous regions based on the reconstruction loss of the decoder. Studies focus on nine invariant mass spectra that contain pairs of objects consisting of one light jet or b jet ...
American Physical Society
Produção Nacional
Revisado por pares
Jamila Alessandra Perini, Alessandra Silva Dias, Leonor Gusmão, Larissa B. Skaf, Anna Beatriz Ribeiro Elias, Paulo Cesar Basta, Marcelo A. Carvalho, Guilherme Suarez‐Kurtz,
Tópico(s): Metabolism and Genetic Disorders
2025 - Lippincott Williams & Wilkins | Pharmacogenetics and Genomics
G. Aad, B. Abbott, K. Abeling, Nils Julius Abicht, S. H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, C. Adam Bourdarios, L. Adamczyk, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adıgüzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, I. Aizenberg, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, Nilima Nilesh Akolkar, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, Guillaume Lucas Albouy, S. Alderweireldt, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, Samuel William Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, M. Alvarez Estevez, A. Álvarez Fernández, M. Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. Amidei, S. P. Amor Dos Santos, K. R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, J. A. Aparisi Pozo, M. A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, N. Aranzabal, S. J. Arbiol Val, C. Arcangeletti, A. T. H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, J. Assahsah, K. Assamagan, R. Astalos, S. Atashi, M. Atkinson, M. Atkinson, Hicham Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T. M. Baer, P. Bagnaia, M. Bahmani, A. J. Bailey, V. R. Bailey, J. T. Baines, L. Baines, O. K. Baker, E. Bakos, D. Bakshi Gupta, Veena Balakrishnan, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, E. Banaś, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, Marten Zefanja Barel, K. N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baroň, D. A. Baron Moreno, A. Baroncelli, G. Barone, A. J. Barr, J. D. Barr, L. Barranco Navarro, F. Barreiro, F. Barreiro, U. Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartoš, A. Basan, M. Baselga, A. Bassalat, M. J. Basso, C. R. Basson, R. L. Bates, S. Batlamous, J. R. Batley, B. Batool, M. Battaglia, D. Battulga, M. Bauce, Michael Bauer, P. Bauer, L. T. Bazzano Hurrell, J. B. Beacham, T. Beau, T. Beau, T. Beau, F. Becherer, P. Bechtle, H. P. Beck, K. Becker, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, M. Benoit, J. R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F. U. Bernlochner, F. Bernon, Adrian Berrocal Guardia, T. Berry, P. Berta, A. Berthold, I. A. Bertram, S. Bethke, A. Betti, A. J. Bevan, Naman Kumar Bhalla, M. Bhamjee, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, V. Bhopatkar, R. Bi, R. M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, M. Bindi, A. Bingül, C. Bini, A. Biondini, C. J. Birch-sykes, G. A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J. P. Biswal, D. Biswas, A. Bitadze, K. Bjørke, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, J. Blumenthal, G. J. Bobbink, V. S. Bobrovnikov, G. J. Bobbink, B. Boehm, D. Bogavac, A. G. Bogdanchikov, C. Böhm, V. Boisvert, P. Bokan, T. Bołd, M. Bomben, M. Bóna, M. Boonekamp, C. D. Booth,
A measurement of the mass of the Higgs boson combining the H→ZZ*→4ℓ and H→γγ decay channels is presented. The result is based on 140 fb−1 of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of 125.11±0.09(stat)±0.06(syst)=125.11±0.11 GeV. This corresponds to a 0.09% precision achieved on this fundamental ...
American Physical Society
Produção Nacional
Luiz Felipe Castro Vaz Poloniato, Gabriel Gonçalves Rezende Oliveira, Hiago Vinícius de França, Renan Rodrigues de Oliveira Cunha, Gabriel de Oliveira Pereira, Fernanda Furtado Fernandes, Pedro Paulo Martins Ferreira Neto, Guilherme Fontes de Sousa Skaf Abdala, Isadora Garcia de Paula, Vinícius Coutinho Mendanha, Heitor Carvalho Sintra, Davi Mamede Da Luz, Eduarda Arantes Gonçalves,
O refluxo gastroesofágico (DRGE) é uma condição na qual o conteúdo ácido do estômago reflui para o esôfago, causando sintomas como azia, regurgitação e dor no peito. O diagnóstico do DRGE é baseado na avaliação clínica e pode envolver testes de monitoramento do pH esofágico. O tratamento do DRGE é multifacetado e inclui intervenções medicamentosas e não medicamentosas. Os inibidores da bomba de prótons (IBPs) são frequentemente prescritos para reduzir a produção de ácido gástrico e aliviar os sintomas. ...
Tópico(s): Esophageal and GI Pathology
2023 - | Brazilian Journal of Implantology and Health Sciences
G. Aad, E. Aakvaag, B. Abbott, K. Abeling, Nils Julius Abicht, S. H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, C. Adam Bourdarios, L. Adamczyk, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adıgüzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, I. Aizenberg, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, Nilima Nilesh Akolkar, S. Aktas, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, Guillaume Lucas Albouy, S. Alderweireldt, Z. L. Alegria, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, Samuel William Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, M. Alvarez Estevez, A. Álvarez Fernández, M. Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. Amidei, S. P. Amor Dos Santos, K. R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, M. T. Anthony, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, J. A. Aparisi Pozo, M. A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S. J. Arbiol Val, C. Arcangeletti, A. T. H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, K. Assamagan, R. Astalos, S. Atashi, M. Atkinson, M. Atkinson, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T. M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, A. J. Bailey, V. R. Bailey, J. T. Baines, L. Baines, O. K. Baker, E. Bakos, D. Bakshi Gupta, Veena Balakrishnan, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, E. Banaś, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, Marten Zefanja Barel, K. N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baroň, D. A. Baron Moreno, A. Baroncelli, G. Barone, A. J. Barr, J. D. Barr, F. Barreiro, F. Barreiro, U. Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartoš, A. Basan, M. Baselga, A. Bassalat, M. J. Basso, C. R. Basson, R. L. Bates, S. Batlamous, J. R. Batley, B. Batool, M. Battaglia, D. Battulga, M. Bauce, Michael Bauer, Michael Bauer, L. T. Bazzano Hurrell, J. B. Beacham, T. Beau, T. Beau, T. Beau, P. Bechtle, H. P. Beck, K. Becker, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, Kees Benkendorfer, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F. U. Bernlochner, F. Bernon, Adrian Berrocal Guardia, T. Berry, P. Berta, A. Berthold, I. A. Bertram, S. Bethke, A. Betti, A. J. Bevan, Naman Kumar Bhalla, M. Bhamjee, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, Kartik Deepak Bhide, V. Bhopatkar, R. M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C. S. Billingsley, M. Bindi, A. Bingül, C. Bini, A. Biondini, C. J. Birch-sykes, G. A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J. P. Biswal, D. Biswas, K. Bjørke, I. Bloch, A. Blue, U. Blumenschein, J. Blumenthal, V. S. Bobrovnikov, G. J. Bobbink, B. Boehm, D. Bogavac, A. G. Bogdanchikov, C. Böhm, V. Boisvert, P. Bokan, T. Bołd, M. Bomben, M. Bóna, M. Boonekamp, C. D. Booth, A. G. Borbély, Iurii Bordulev, H. M. Borecka-Bielska, G. Borissov,
Abstract The ATLAS trigger system is a crucial component of the ATLAS experiment at the LHC. It is responsible for selecting events in line with the ATLAS physics programme. This paper presents an overview of the changes to the trigger and data acquisition system during the second long shutdown of the LHC, and shows the performance of the trigger system and its components in the proton-proton collisions during the 2022 commissioning period as well as its expected performance in proton-proton and ...
Institute of Physics
Produção Nacional
Revisado por pares
Paulo C. T. Souza, Tsjerk A. Wassenaar, Munir S. Skaf, Siewert J. Marrink,
Toll-like receptors 4 (TLR4) are transmembrane proteins of the innate immune system responsible for recognizing lipopolysaccharides (LPS), essential components of the Gram-negative bacteria outer membrane. The association of LPS to TLR4 promotes its migration to cell membrane rafts and its homodimerization, which triggers an inflammatory response. Given its role in the innate immune system, TLR4 is an important target in drug development, especially for the treatment of infections and acute inflammations ...
Tópico(s): Water Systems and Optimization
2018 - Elsevier BV | Biophysical Journal
G. Aad, E. Aakvaag, B. Abbott, Sara Abdelhameed, K. Abeling, Nils Julius Abicht, S. H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B. S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S. V. Addepalli, M. J. Addison, J. Adelman, A. Adıgüzel, T. Adye, A. A. Affolder, Y. Afik, M. N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, F. Ahmadov, W. S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T. P. A. Åkesson, A. V. Akimov, D. Akiyama, Nilima Nilesh Akolkar, S. Aktas, K. Al Khoury, G. L. Alberghi, J. Albert, P. Albicocco, Guillaume Lucas Albouy, S. Alderweireldt, Z. L. Alegria, M. Aleksa, I. N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H. M. J. Ali, S. Ali, Samuel William Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B. M. M. Allbrooke, J. F. Allen, C. Flores, P. P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Zainab Mohammad K Alsolami, M. Alvarez Estevez, A. Álvarez Fernández, M. Alves Cardoso, M. G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C. G. Ames, D. Amidei, B. Amini, Kyle Amirie, S. P. Amor Dos Santos, K. R. Amos, Dimitra Amperiadou, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J. K. Anders, Allan Anderson, S. Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A. V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M. A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S. J. Arbiol Val, C. Arcangeletti, A. T. H. Arce, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N. A. Asbah, Rachel Amy Ashby Pickering, K. Assamagan, R. Astalos, K. S. V. Astrand, S. Atashi, M. Atkinson, M. Atkinson, H. Atmani, P. A. Atmasiddha, K. Augsten, S. Auricchio, A. D. Auriol, V. A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T. M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J. T. Baines, J. T. Baines, O. K. Baker, E. Bakos, D. Bakshi Gupta, Luiz Eduardo Balabram Filho, Veena Balakrishnan, R. Balasubramanian, E. M. Baldin, P. Balek, E. Ballabene, F. Balli, L. M. Baltes, W. K. Balunas, J. Balz, I. Bamwidhi, E. Banaś, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, L. Barak, E. L. Barberio, D. Barberis, M. Barbero, Marten Zefanja Barel, T. Barillari, M-S. Barisits, T. Barklow, P. Baroň, D. A. Baron Moreno, A. Baroncelli, A. J. Barr, J. D. Barr, F. Barreiro, F. Barreiro, U. Barron, M. G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A. E. Barton, P. Bartoš, A. Basan, M. Baselga, A. Bassalat, M. J. Basso, Susan Bataju, R. Bate, R. L. Bates, Souad Batlamous, B. Batool, M. Battaglia, D. Battulga, M. Bauce, Michael Bauer, Michael Bauer, L. T. Bazzano Hurrell, J. B. Beacham, T. Beau, T. Beau, T. Beau, P. Bechtle, H. P. Beck, K. Becker, A. J. Beddall, V. A. Bednyakov, C. P. Bee, L. J. Beemster, T. A. Beermann, M. Begalli, M. Begel, A. Behera, J. K. Behr, J. F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, Kees Benkendorfer, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F. U. Bernlochner, F. Bernon, Adrian Berrocal Guardia, T. Berry, P. Berta, A. Berthold, S. Bethke, A. Betti, A. J. Bevan, Naman Kumar Bhalla, S. Bhatta, D. S. Bhattacharya, P. Bhattarai, Kartik Deepak Bhide, V. Bhopatkar, R. M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C. S. Billingsley, Yassine Bimgdi, M. Bindi, A. Bingül, C. Bini, G. A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J. P. Biswal, D. Biswas, I. Bloch, A. Blue, U. Blumenschein, J. Blumenthal, V. S. Bobrovnikov, G. J. Bobbink, B. Boehm, D. Bogavac, A. G. Bogdanchikov, Laura Boggia, C. Böhm, V. Boisvert, P. Bokan, T. Bołd, M. Bomben, M. Bóna, M. Boonekamp, C. D. Booth, A. G. Borbély, Iurii Bordulev,
This Letter presents results from a combination of searches for Higgs boson pair production using 126-140 fb^{-1} of proton-proton collision data at sqrt[s]=13 TeV recorded with the ATLAS detector. At 95% confidence level (CL), the upper limit on the production rate is 2.9 times the standard model (SM) prediction, with an expected limit of 2.4 assuming no Higgs boson pair production. Constraints on the Higgs boson self-coupling modifier κ_{λ}=λ_{HHH}/λ_{HHH}^{SM}, and the quartic HHVV coupling modifier ...
American Physical Society