Christof Holliger, M. M. Alves, Diana Andrade, İrini Angelidaki, Sergi Astals, Urs Baier, Claire Bougrier, Pierre Buffière, Marta Carballa, Vinnie de Wilde, Florian Ebertseder, Belén Fernández, E. Ficara, Ioannis A. Fotidis, Jean‐Claude Frigon, Hélène Fruteau de Laclos, Dara S.M. Ghasimi, Gabrielle Hack, Mathias Hartel, J. Heerenklage, Ilona Sárvári Horváth, Pavel Jeníček, Konrad Koch, Judith Krautwald, Javier Lizasoain, Jing Liu, Lona Mosberger, Mihaela Nistor, Hans Oechsner, João Vítor Oliveira, M. P. Paterson, André Pauss, Sébastien Pommier, I. Porqueddu, F. Raposo, Thierry Ribeiro, Florian Rüsch Pfund, Sten Strömberg, Michel Torrijos, M.H.A. van Eekert, Jules B. van Lier, Harald Wedwitschka, Isabella Wierinck,
Production of biogas from different organic materials is a most interesting source of renewable energy. The biomethane potential (BMP) of these materials has to be determined to get insight in design parameters for anaerobic digesters. Although several norms and guidelines for BMP tests exist, inter-laboratory tests regularly show high variability of BMPs for the same substrate. A workshop was held in June 2015, in Leysin, Switzerland, with over 40 attendees from 30 laboratories around the world, ...
Tópico(s): Carbon Dioxide Capture Technologies
2016 - Pergamon Press | Water Science & Technology
Raju Mandal, Klára Kohoutová, Olívia Petrvalská, Matej Horvath, Pavel Srb, Václav Veverka, Veronika Obšilová, Tomáš Obšil,
Transcription factor p53 protects cells against tumorigenesis when subjected to various cellular stresses. Under these conditions, p53 interacts with transcription factor Forkhead box O (FOXO) 4, thereby inducing cellular senescence by upregulating the transcription of senescence-associated protein p21. However, the structural details of this interaction remain unclear. Here, we characterize the interaction between p53 and FOXO4 by NMR, chemical cross-linking, and analytical ultracentrifugation. ...
Tópico(s): Cell death mechanisms and regulation
2022 - Wiley | Protein Science
Luca Vannucci, Anna Fišerová, Kashinath Sadalapure, Thisbe K. Lindhorst, Markéta Kuldová, P Roßmann, Ondřej Horváth, Vladimı́r Křen, Pavel Krist, Karel Bezouška, Martina Luptovcová, Franco Mosca, Miloslav Pospı́šil,
Glyco-coat changes on cancer cells due to aberrant glycosylation are potential targets for immune recognition through lectin-like receptors on immune cells. These cells include natural killer (NK), CD8+ and CD4+ lymphocytes, all reported to have, together with cytokines, important functions in antitumor immunity. The aim of this study was to evaluate a possible role of synthetic monodisperse multivalent neo-glycoconjugates, namely glycodendrimers, as a new approach to anticancer immune modulation ...
Tópico(s): Glycosylation and Glycoproteins Research
2014 - Spandidos Publishing | International Journal of Oncology
Luca Vannucci, Anna Fišerová, Kashinath Sadalapure, Thisbe K. Lindhorst, Markéta Kuldová, P Roßmann, Ondřej Horváth, Vladimı́r Křen, Pavel Krist, Karel Bezouška, Martina Luptovcová, Franco Mosca, Miloslav Pospı́šil,
Glyco-coat changes on cancer cells due to aberrant glycosylation are potential targets for immune recognition through lectin-like receptors on immune cells. These cells include natural killer (NK), CD8+ and CD4+ lymphocytes, all reported to have, together with cytokines, important functions in antitumor immunity. The aim of this study was to evaluate a possible role of synthetic monodisperse multivalent neo-glycoconjugates, namely glycodendrimers, as a new approach to anticancer immune modulation ...
Tópico(s): Glycosylation and Glycoproteins Research
2003 - Spandidos Publishing | International Journal of Oncology
Robert Fledrich, Manoj Mannil, Andreas Leha, Caroline Ehbrecht, Alessandra Solari, Ana L. Pelayo‐Negro, José Berciano, Beate Schlotter‐Weigel, Tuuli J. Schnizer, Thomas Prukop, Natalia García-Angarita, Dirk Czesnik, Jana Haberlová, Radim Mazanec, Walter Paulus, Tim Beissbarth, Maggie C. Walter, CMT- TRIAAL, Jean‐Yves Hogrel, O. Dubourg, Angelo Schenone, Jonathan Baets, Peter De Jonghe, Michael E. Shy, Rita Horváth, Davide Pareyson, Pavel Seeman, Peter Young, Michael W. Sereda,
Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited neuropathy, a debilitating disease without known cure. Among patients with CMT1A, disease manifestation, progression and severity are strikingly variable, which poses major challenges for the development of new therapies. Hence, there is a strong need for sensitive outcome measures such as disease and progression biomarkers, which would add powerful tools to monitor therapeutic effects in CMT1A.We established a pan-European ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2017 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Eva Chvostová, J. Horváth, Pavel Konopík, Sylwia Rzepa, Daniel Melzer,
Abstract Degradation of metallic materials can decrease mechanical properties of metal constructions and components in thermal power plants during their operation and consequently lead to loss of safety and reliability. It is difficult to remove material from the pressure system of the equipment being operated. Therefore, the effort is to design, produce and subsequently install exposure channels, which will allow to remove and evaluate samples of exposed material without intervention into the pressure ...
Tópico(s): Aluminum Alloy Microstructure Properties
2020 - IOP Publishing | IOP Conference Series Materials Science and Engineering
Markus Brown, Frank P. Assen, Alexander Leithner, Jun Abe, Helga Schachner, Gabriele Asfour, Zsuzsanna Bagó-Horváth, Jens V. Stein, Pavel Uhrín, Michael Sixt, Dontscho Kerjaschki,
An alternate route for metastatic cells Metastatic tumor cells are thought to reach distant organs by traveling through the blood circulation or the lymphatic system. Two studies of mouse models now suggest a hybrid route for tumor cell dissemination. Pereira et al. and Brown et al. used distinct methodologies to monitor the fate of tumor cells in lymph nodes. They found that tumor cells could invade local blood vessels within a node, exit the node by entering the blood circulation, then go on to ...
Tópico(s): Angiogenesis and VEGF in Cancer
2018 - American Association for the Advancement of Science | Science
Hamza Bennani, Nicolas Fanta, Pavel Gertler, Roman Horváth,
We examine the European Central Bank’s ad-hoc communication and explore how it informs future monetary policy decisions. Using the rich dataset of the inter-meeting verbal communication by the members of the European Central Bank’s Governing Council between 2008 and 2016, we construct a measure of communication evaluating its inclination towards easing, tightening or maintaining the monetary policy stance. We find that this measure provides useful additional information about future monetary policy ...
Tópico(s): Italy: Economic History and Contemporary Issues
2020 - Elsevier BV | Journal of International Money and Finance
Keyvan D. Nikghalb, Nicholas Horvath, Jesse Prelesnik, Orion GB Banks, Pavel A. Filipov, R. David Row, Travis J. Roark, John M. Antos,
Sortase-catalyzed transacylation reactions are widely used for the construction of non-natural protein derivatives. However, the most commonly used enzyme for these strategies (sortase A from Staphylococcus aureus) is limited by its narrow substrate scope. To expand the range of substrates compatible with sortase-mediated reactions, we characterized the in vitro substrate preferences of eight sortase A homologues. From these studies, we identified sortase A enzymes that recognize multiple substrates ...
Tópico(s): Biochemical and Structural Characterization
2017 - Wiley | ChemBioChem
Luděk Kořený, Roman Sobotka, Julie Kovářová, Anna Gnipová, Pavel Flegontov, Anton Horváth, Miroslav Obornı́k, Francisco J. Ayala, Julius Lukeš,
Heme is an iron-coordinated porphyrin that is universally essential as a protein cofactor for fundamental cellular processes, such as electron transport in the respiratory chain, oxidative stress response, or redox reactions in various metabolic pathways. Parasitic kinetoplastid flagellates represent a rare example of organisms that depend on oxidative metabolism but are heme auxotrophs. Here, we show that heme is fully dispensable for the survival of Phytomonas serpens , a plant parasite. Seeking ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
This paper examines the financial market impact of intermeeting communication of the members of the European Central Bank’s Governing Council (GC) using high frequency data between July 2008 and January 2014. Constructing a rich dataset of GC members’ public statements (speeches, conference discussions and media interviews) between monetary policy meetings allows us to investigate a detailed pattern of market responses to the ad-hoc communication of central bankers. Using least squares and quantile ...
Tópico(s): Italy: Economic History and Contemporary Issues
2018 - Elsevier BV | Journal of Financial Stability
Petr Hamal, Jiří Ostřanský, Miloš Dendis, Radek Horváth, Filip Růžička, Vladimı́r Buchta, Marcela Vejsová, Pavel Sauer, Petr Hejnar, Vladislav Raclavský,
Pichia fabianii, a yeast rarely causing human infections, was isolated from the blood of a patient with aortic valve endocarditis. The isolates were initially identified biochemically as Candida pelliculosa, but based on direct sequencing of the ITS2 region of rRNA, they were subsequently reidentified as P. fabianii. Antifungal therapy with fluconazole and later with voriconazole led to the development of resistant variants which had high MIC values to both antifungals. Strong biofilm formation ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2008 - Oxford University Press | Medical Mycology
Héléna A. Gaspar, Pavel Sidorov, Dragos Horvath, Igor I. Baskin, Gilles Marcou, Alexandre Varnek,
Tópico(s): Computational Drug Discovery Methods
2017 - Springer Nature (Netherlands) | Challenges and advances in computational chemistry and physics
Petr Münster, Tomáš Horváth, Josef Vojtěch, Ondřej Havliš, Martin Šlapák, Pavel Škoda, Jan Radil, Radek Velc, Miloslav Hůla,
Currently, individual optical fibers are mostly used for each non-data application, which is very inefficient and uneconomical. Sharing a single fiber for multiple applications is a promising solution. However, in the case of a non-data application, the situation is much more complicated compared to data because of special application´s requirements. In laboratory setup, we performed a measurement with a standard G.652D optical fiber for analyzing possible interaction of stable frequency/accurate ...
Tópico(s): Advanced Optical Network Technologies
2017 - Taylor & Francis | Fiber & Integrated Optics
Pavol Horváth, Pavel Kučera, Pavel Nedbal, Jindřich Kupec, Rostislav Polášek,
Atrioventrikulární blokáda prvního stupně (AV blokáda I. st.) je definována jako prodloužení PR intervalu nad 200 ms [1]. Při extrémně dlouhém PR intervalu může vzniknout situace obdobná pacemakerovému syndromu, tedy kolize systoly síní a komor, provázená podobnými příznaky včetně symptomů srdečního selhání i při normální systolické funkci levé komory [2]. Označuje se jako pseudopacemakerový syndrom [3-10]. Uvádíme případ pacientky s výrazně dlouhým PR intervalem po náhradě mitrální chlopně s příznaky ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2012 - Česká kardiologická společnost | Cor et Vasa
Pavel Sikora, Tomáš Horváth, Petr Münster, Václav Oujezský,
Sophisticated dynamic bandwidth allocation (DBA) algorithms can dramatically improve or worsen throughput and delay in whole networks. It is very important to choose the right DBA algorithm. Our work tests static assignment and three DBA algorithms, namely GigaPON Access Network DBA, Hybrid Reporting Allocation, and modified Max–Min Fair. All tests were made on our simulator of ten-gigabit passive optical network DBA specially developed for testing DBA algorithms. The tests verify delay of each optical ...
Tópico(s): Advanced Optical Network Technologies
2019 - Multidisciplinary Digital Publishing Institute | Electronics
Vojtěch Votruba, Ivan Diviš, P Lucie, Pavel Zeman, Libor Beránek, Jakub Horváth, Jan Smolík,
Abstract Additive manufacturing (AM) is a progressive technology which holds promise for manufacturing of heat resistant super alloys. One of the most productive methods is wire arc additive manufacturing (WAAM). In this article, an alternative WAAM strategy is investigated. Experimental clads and material tests were performed to evaluate the material properties obtained through a cold metal transfer (CMT) discontinuous WAAM of Inconel 625 alloy. Using the modern terminology of Fronius Gmbh this method ...
Tópico(s): Welding Techniques and Residual Stresses
2022 - Springer Science+Business Media | The International Journal of Advanced Manufacturing Technology
William Bort, Igor I. Baskin, Timur Gimadiev, Artem Mukanov, Ramil Nugmanov, Pavel Sidorov, Gilles Marcou, Dragos Horvath, Olga Klimchuk, Timur Madzhidov, Alexandre Varnek,
Abstract The “creativity” of Artificial Intelligence (AI) in terms of generating de novo molecular structures opened a novel paradigm in compound design, weaknesses (stability & feasibility issues of such structures) notwithstanding. Here we show that “creative” AI may be as successfully taught to enumerate novel chemical reactions that are stoichiometrically coherent. Furthermore, when coupled to reaction space cartography, de novo reaction design may be focused on the desired reaction class. A sequence- ...
Tópico(s): Bioinformatics and Genomic Networks
2021 - Nature Portfolio | Scientific Reports
Pavel Mozgunov, Marco Beccuti, András Horváth, Thomas Jaki, Roberta Sirovich, Enrico Bibbona,
This work reviews deterministic and diffusion approximations of the stochastic chemical reaction networks and explains their applications. We discuss the added value the diffusion approximation provides for systems with different phenomena, such as a deficiency and a bistability. It is advocated that the diffusion approximation can be considered as an alternative theoretical approach to study the reaction networks rather than a simulation shortcut. We discuss two examples in which the diffusion ...
Tópico(s): stochastic dynamics and bifurcation
2018 - Springer Science+Business Media | Reaction Kinetics Mechanisms and Catalysis
Kamil S. Sitarz, Patrick Yu‐Wai‐Man, Angela Pyle, Joanna D. Stewart, Bernd Rautenstrauß, Pavel Seeman, Mary M. Reilly, Rita Horváth, Patrick F. Chinnery,
ARTICLE Sir, We read with great interest the report of a Tunisian family by Rouzier et al . (2011) describing the neurological disorder linked to a novel heterozygous missense mutation in MFN2 (1p36.2) (Rouzier et al ., 2011). MFN2 mutations typically cause autosomal dominant axonal Charcot–Marie–Tooth disease (CMT2A, OMIM 609260), with peripheral nerve degeneration occasionally associated with visual failure and optic atrophy (Zuchner et al ., 2004, 2006). Interestingly, the clinical manifestations among mutational ...
Tópico(s): Genetic Neurodegenerative Diseases
2012 - Oxford University Press | Brain
L. Juha, Michal Bittner, D. Chvostová, J. Krása, M. Kozlová, M. Pfeifer, J. Polan, A. R. Präg, B. Rus, M. Stupka, Josef Feldhaus, Vit Létal, Zdenek Otcenasek, J. Krzywiński, R. Nietubyć, J.B. Pełka, A. Andrejczuk, R. Sobierajski, L. Ryć, F.P. Boody, Henryk Fiedorowicz, Andrzej Bartnik, J. Mikołajczyk, R. Rakowski, Pavel Kubát, L. Pı́na, Martin P. Horvath, Michael Grisham, G. Vaschenko, Carmen S. Menoni, J. J. Rocca,
For conventional wavelength (UV-vis-IR) lasers delivering radiation energy to the surface of materials, ablation thresholds, ablation (etch) rates, and the quality of ablated structures often differ dramatically between short (typically nanosecond) and ultrashort (typically femtosecond) pulses. Various short-wavelength (<100 nm) lasers emitting pulses with durations ranging from ~10 fs to ~1 ns have recently been put into routine operation. This makes it possible to investigate how ablation characteristics ...
Tópico(s): Laser-induced spectroscopy and plasma
2005 - SPIE | Journal of Micro/Nanolithography MEMS and MOEMS
Toshihiro Fujii, M. Malacari, M. Bertaina, M. Casolino, B. R. Dawson, P. Horváth, M. Hrabovský, Jiaqi Jiang, Dušan Mandát, Ariel Matalon, J. N. Matthews, Pavel Motloch, M. Palatka, M. Pech, P. Privitera, P. Schovánek, Y. Takizawa, S. B. Thomas, P. Trávnı́ček, K. Yamazaki,
Tópico(s): Radio Astronomy Observations and Technology
2015 - Elsevier BV | Astroparticle Physics
Andrea Balážová, Júlia Urdová, František Bilka, Ivana Holková, Branislav Horváth, Vladimír Forman, Pavel Mučaji,
The basal production of secondary metabolites in medicinal plants is limited. One of the effective approaches that encourages plants to produce a remarkable amount of precious compounds is an application of elicitors. Our work was focused on the elicitation of Eschscholzia californica Cham. suspension cultures using various concentrations of MnCl₂ (5; 10; 15 mg/L) with the aim of evaluating its effect on sanguinarine, chelerythrine, and macarpine production and gene expression of enzymes involved ...
Tópico(s): Plant Genetic and Mutation Studies
2018 - Multidisciplinary Digital Publishing Institute | Molecules
Petr Dejdar, Pavel Záviška, Soběslav Valach, Petr Münster, Tomáš Horváth,
This paper aims to evaluate detection algorithms for perimeter security systems based on phase-sensitive optical time-domain reflectometry (Φ-OTDR). Our own designed and developed sensor system was used for the measurement. The main application of the system is in the area the perimeter fencing intrusion detection. The system is unique thanks to the developed motherboard, which contains a field-programmable gate array (FPGA) that takes care of signal processing. This allows the entire system to be ...
Tópico(s): Semiconductor Lasers and Optical Devices
2022 - Multidisciplinary Digital Publishing Institute | Sensors
Pavao Andričević, Gábor Náfrádi, Márton Kollár, Bálint Náfrádi, S. Lilley, C. J. Kinane, Pavel Frajtag, Andrzej Sienkiewicz, Andreas Pautz, Endre Horváth, L. Forró,
Interest in fast and easy detection of high-energy radiation (x-, γ-rays and neutrons) is closely related to numerous practical applications ranging from biomedicine and industry to homeland security issues. In this regard, crystals of hybrid halide perovskite have proven to be excellent detectors of x- and γ-rays, offering exceptionally high sensitivities in parallel to the ease of design and handling. Here, we demonstrate that by assembling a methylammonium lead tri-bromide perovskite single crystal ( ...
Tópico(s): Radiation Detection and Scintillator Technologies
2021 - Nature Portfolio | Scientific Reports
Pavel Sidorov, Israel Desta, Matthieu Chessé, Dragos Horvath, Gilles Marcou, Alexandre Varnek, Elisabeth Davioud–Charvet, Mourad Elhabiri,
Abstract 3‐Benzylmenadiones are potent antimalarial agents that are thought to act through their 3‐benzoylmenadione metabolites as redox cyclers of two essential targets: the NADPH‐dependent glutathione reductases (GRs) of Plasmodium ‐parasitized erythrocytes and methemoglobin. Their physicochemical properties were characterized in a coupled assay using both targets and modeled with QSPR predictive tools built in house. The substitution pattern of the west/east aromatic parts that controls the oxidant ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2016 - Wiley | ChemMedChem
L. Dózsa, Zs. J. Horváth, Pavel Hubı́k, J. Krištofik, Jiřı́ J. Mareš, E. Gombia, P. Frigeri, R. Mosca, Stefano Franchi, B. Pécz, László Dobos,
Defects created by self-organized InAs quantum dot growth in a GaAs matrix were investigated. Growth of the quantum dots was found to enhance strongly the tendency towards inhomogeneous growth. The inhomogeneity seems to stem from point defect clusters generated in the vicinity of a molecular beam epitaxy (MBE)/atomic layer MBE (ALMBE) interface. The point defects identified are characteristic of MBE and ALMBE GaAs layers. The InAs quantum dot states and interface states are not clearly detected since ...
Tópico(s): Quantum Dots Synthesis And Properties
2003 - Wiley | Physica status solidi. C, Conferences and critical reviews/Physica status solidi. C, Current topics in solid state physics
Cameron M. Naraine, Jocelyn N. Westwood‐Bachman, Cameron Horvath, Mirwais Aktary, Andrew P. Knights, Jens H. Schmid, Pavel Cheben, Jonathan D. B. Bradley,
Abstract Subwavelength grating (SWG) metamaterial waveguides and ring resonators on a silicon nitride platform are proposed and demonstrated. The SWG waveguide is engineered such that a large overlap of 53% of the Bloch mode with the top cladding material is achieved, demonstrating excellent potential for applications in evanescent field sensing and light amplification. The devices, which have critical dimensions greater than 100 nm, are fabricated using a commercial rapid turn‐around silicon nitride ...
Tópico(s): Advanced Fiber Optic Sensors
2022 - Wiley | Laser & Photonics Review
Angela Serra, Michele Fratello, Antonio Federico, Ravi Ojha, Riccardo Provenzani, Ervin Tasnádi, Luca Cattelani, Giusy del Giudice, Pia Kinaret, Laura Aliisa Saarimäki, Alisa Pavel, Suvi Kuivanen, Vincenzo Cerullo, Olli Vapalahti, Péter Horváth, A. Di Lieto, Jari Yli‐Kauhaluoma, Giuseppe Balistreri, Dario Greco,
Abstract The pharmacological arsenal against the COVID-19 pandemic is largely based on generic anti-inflammatory strategies or poorly scalable solutions. Moreover, as the ongoing vaccination campaign is rolling slower than wished, affordable and effective therapeutics are needed. To this end, there is increasing attention toward computational methods for drug repositioning and de novo drug design. Here, multiple data-driven computational approaches are systematically integrated to perform a virtual ...
Tópico(s): interferon and immune responses
2021 - Oxford University Press | Briefings in Bioinformatics
Kyrylo Klimenko, S. А. Lyakhov, Marina O. Shibinskaya, Alexander Karpenko, Gilles Marcou, Dragos Horvath, Marina A. Zenkova, Е. П. Гончарова, Р. Н. Амирханов, Andrei A. Krysko, Sergei A. Andronati, Igor A. Levandovskiy, Pavel Polishchuk, V. Е. Kuz’min, Alexandre Varnek,
This paper describes computer-aided design of new anti-viral agents against Vaccinia virus (VACV) potentially acting as nucleic acid intercalators. Earlier obtained experimental data for DNA intercalation affinities and activities against Vesicular stomatitis virus (VSV) have been used to build, respectively, pharmacophore and QSAR models. These models were used for virtual screening of a database of 245 molecules generated around typical scaffolds of known DNA intercalators. This resulted in 12 hits ...
Tópico(s): Virus-based gene therapy research
2017 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters