... 1016/B978-0-12-420002-9.00005-6Marcin Zalewski, Paweł Sienkiewicz, Krzysztof Kujawa, Izabela Hajdamowicz, Werner Ulrich Ground ...
Tópico(s): Wildlife Ecology and Conservation
1992 - University of Chicago Press | The American Naturalist
Grzegorz Gajos, J Zalewski, Paweł Rostoff, Jadwiga Nessler, W Piwowarska, Anetta Undas,
Objective— The goal of this study was to investigate whether omega-3 polyunsaturated fatty acids (n-3 PUFA) are able to alter plasma fibrin clot properties and reduce thrombin formation in stable coronary artery disease patients undergoing percutaneous coronary intervention (PCI). Methods and Results— In an investigator-initiated, prospective, double-blind, placebo-controlled, randomized study, patients undergoing PCI who received standard pharmacotherapy were assigned to the treatment with 1 g/day ...
Tópico(s): Coronary Interventions and Diagnostics
2011 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Marcin Zalewski, Paweł Sienkiewicz, Krzysztof Kujawa, Izabela Hajdamowicz, Werner Ulrich,
Neutral theory focuses on random dispersal and species equivalence, and challenges views on the ecological importance of life history traits and habitat properties in explaining community assembly and the spatial distribution of species. Ground beetles are a popular model taxon to test predictions of contrasting macroecological theories. Here we investigate the effects of habitat properties and life history on the occurrence and community structure of 71 carabid beetle species inhabiting 15 lake ...
Tópico(s): Species Distribution and Climate Change
2012 - Finnish Zoological and Botanical Publishing Board | Annales Zoologici Fennici
Tadeusz Ossowski, Dorota Zarzeczańska, Leszek Zalewski, Paweł Niedziałkowski, Radosław Majewski, Aneta Szymańska,
The synthesis of a lysine-like chromo-ionophore and its derivatives, useful in peptide chemistry, is described. The influence of the peptide framework on the anthraquinone properties is examined with spectroscopic and electrochemical methods.
Tópico(s): Analytical Chemistry and Sensors
2005 - Elsevier BV | Tetrahedron Letters
Maciej Woźny, Stefan Dobosz, Kazimierz Obremski, Piotr Hliwa, Piotr Gomułka, Alicja Łakomiak, Rafał Różyński, Tomasz Zalewski, Paweł Brzuzan,
To gain insight into the possible implications for aquaculture of the presence of ZEN in fish feed at the EC guidance level, we determined the effects of over two months of feeding of premarket size rainbow trout (~ 250 g) with ZEN-contaminated feed at a dose of 1.81 mg·kg− 1 feed (90.5% of the current guidance value) under aquaculture conditions. After 37 and 71 days of the experiment, both control and ZEN-challenged fish were weighed and measured to assess their growth performance. To examine the ...
Tópico(s): Sperm and Testicular Function
2015 - Elsevier BV | Aquaculture
Robert Zalewski, Paweł Chodkiewicz, Meir Shillor,
The control of vibrations of a mass-spring system with a damper made of granular material is modeled, numerically simulated and experimentally verified. The damper consists of a hermetically closed flexible sleeve filled with granular material. Pumping air out of or into the sleeve increases or decreases the under-pressure, which increases or decreases the compression of the granules, causing the system to become more or less rigid. This, in turn, increases or decreases the energy dissipation, which ...
Tópico(s): Contact Mechanics and Variational Inequalities
2016 - Elsevier BV | Applied Mathematical Modelling
Piotr Bartkowski, Robert Zalewski, Paweł Chodkiewicz,
Tópico(s): Fluid Dynamics and Vibration Analysis
2018 - Springer Science+Business Media | Archives of Civil and Mechanical Engineering
Robert Zalewski, Paweł Chodkiewicz,
In this paper, the authors focus on the proposition of an innovative semi-active linear damper prototype working on the basis of granularmaterials. Vacuum Packed Particles (VPP) belong to the class of materials whose mechanical (rheological, dissipative) propertiesmay be quickly changed by applying a partial vacuum inside the system. The concept of an innovative linear damper based on VPP is presented in the paper. Typical experimental results are presented to reveal changeable damping characteristics ...
Tópico(s): Hydraulic and Pneumatic Systems
2016 - Exeley Inc | Journal of Theoretical and Applied Mechanics/Mechanika Teoretyczna i Stosowana
Produção Nacional
Revisado por pares
Brain metastases are a common complication of non-small-cell lung cancer (NSCLC). The role of chemotherapy in the treatment of brain metastases has not been clearly defined. Emerging case reports of patients with recurrent NSCLC treated as part of the Expanded Access Programme reveal that gefitinib (‘Iressa’, ZD1839) has clinical activity in some patients with brain metastases. Here, we describe a number of case studies documenting the response of patients with brain metastases to treatment with gefitinib. ...
Tópico(s): Lung Cancer Research Studies
2003 - Springer Nature | British Journal of Cancer
James Frith, Paweł Zalewski, Jacek J. Klawe, Jessie Pairman, Anna Bitner, Małgorzata Tafil‐Klawe, Julia L. Newton,
Introduction: Autonomic dysfunction is common in chronic fatigue syndrome (CFS). This study set out to derive an autonomic biomarker using a comprehensive assessment of heart rate and blood pressure variability. Methods: Heart rate and non-invasive continuous blood pressure measurements (task force monitor) at rest and on standing were performed in CFS (Fukuda n = 68) and matched controls (n = 68) to derive high frequency (HF; parasympathetic) and low frequency (LF; sympathetic) heart rate variability (HRV), ...
Tópico(s): Human Health and Disease
2012 - Oxford University Press | QJM
Maciej Siński, Jacek Lewandowski, Jacek Przybylski, Paweł Zalewski, Bartosz Symonides, Piotr Abramczyk, Zbigniew Gaciong,
Previous studies have shown that hyperoxia-induced deactivation of carotid body chemoreceptors reduces sympathetic activity in hypertensive patients but it does not affect blood pressure. The maintenance of blood pressure can be explained by the direct, vasoconstrictive effect of hyperoxia, which offsets diminished sympathetic activity. This study compares the effect of acute hyperoxia on hemodynamic parameters between hypertensive and normotensive subjects. Twelve males with hypertension (age 39. ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2014 - Springer Nature | Hypertension Research
Sharlene Gill, Yoo‐Joung Ko, M. Christine Cripps, Annie Beaudoin, Sukhbinder Dhesy‐Thind, Muhammad Zulfiqar, Paweł Zalewski, Thuan Do, Pablo Cano, Wwt Lam, Scot Dowden, Helene Grassin, John A. Stewart, Malcolm J. Moore,
4022 Background: There is no current standard of care for APC after 1st line GEM. The CONKO3 study (ASCO 2008) reported a survival benefit with 2nd line oxaliplatin-5FU (OFF), but has not yet been validated. PANCREOX was initiated to evaluate the benefit of mFOLFOX6 vs infusional 5FU/LV in this setting. Methods: Pts with APC previously treated with GEM and ECOG PS <=2 were eligible. 108 pts were randomized. PFS was the primary endpoint in this Canadian, multicentre, open-label study. Secondary outcomes ...
Tópico(s): Colorectal Cancer Treatments and Studies
2014 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Bernard Escudier, M. Dror Michaelson, Robert J. Motzer, Thomas E. Hutson, Joseph I. Clark, Ho Yeong Lim, Emilio Porfiri, Paweł Zalewski, George Kannourakis, Michael Staehler, Jamal Tarazi, Brad Rosbrook, Laura A. Cisar, Seetharaman Hariharan, S. Kim, Brian I. Rini,
In the AXIS trial, axitinib prolonged progression-free survival (PFS) vs sorafenib in patients with advanced renal cell carcinoma (RCC) previously treated with sunitinib or cytokines.In post hoc analyses, patients were grouped by objective response to prior therapy (yes vs no), prior therapy duration (< vs ⩾median), and tumour burden (baseline sum of the longest diameter < vs ⩾median). PFS and overall survival (OS), and safety by type and duration of prior therapy were evaluated.Response to prior therapy did ...
Tópico(s): Cancer Genomics and Diagnostics
2014 - Springer Nature | British Journal of Cancer
Paweł Zalewski, Katarzyna Buszko, Monika Zawadka‐Kunikowska, Joanna Słomko, Justyna Szrajda, Jacek J. Klawe, Małgorzata Tafil‐Klawe, Maciej Siński, Julia L. Newton,
Over recent years, a considerable increase in the popularity of cryostimulation and whole body cryotherapy (WBC) procedures has occurred both among healthy individuals and in various groups of patients, including those with primary untreated hypertension. The aim of this study was to compare the effects of WBC on the functional parameters of cardiovascular system in normotensive and primarily hypertensive individuals. The study included 26 young male volunteers with normal blood pressure range (NormoBP) ...
Tópico(s): Infrared Thermography in Medicine
2014 - Elsevier BV | Cryobiology
Paweł Zalewski, Anna Bitner, Joanna Słomko, Justyna Szrajda, Jacek J. Klawe, Małgorzata Tafil‐Klawe, Julia L. Newton,
The cardiovascular, autonomic and thermal response to whole-body cryostimulation exposure are not completely known. Thus the aim of this study was to evaluate objectively and noninvasively autonomic and thermal reactions observed after short exposure to very low temperatures. We examined 25 healthy men with mean age 30.1±3.7 years and comparable anthropomorphical characteristic. Each subject was exposed to cryotherapeutic temperatures in a cryogenic chamber for 3 min (approx. −120 °C). The cardiovascular ...
Tópico(s): Infrared Thermography in Medicine
2014 - Elsevier BV | Journal of Thermal Biology
Paweł Zalewski, Jacek J. Klawe, Joanna Pawlak, Małgorzata Tafil‐Klawe, Julia L. Newton,
Whole-body cryotherapy (WBC) is an increasing applied cryotherapeutic method, that involves application of a cryotherapeutic factor to stimulate the body by the means of intense hypothermia of virtually the body's entire area. This method is still not well recognized in Western Europe. However in recent years it is becoming increasingly popular in sports medicine and also in clinical application. Cryotherapeutic agents used in WBC are considered to be a strong stress stimulus which is associated ...
Tópico(s): Infrared Thermography in Medicine
2013 - Elsevier BV | Cryobiology
Matthew Bates, Jane Newman, Djordje G. Jakovljević, Kieren G. Hollingsworth, Charlotte L. Alston, Paweł Zalewski, Jacek J. Klawe, Andrew M. Blamire, Guy A. MacGowan, Bernard Keavney, John Bourke, Andrew M. Schaefer, Robert McFarland, Julia L. Newton, Douglass M. Turnbull, Robert W. Taylor, Michael I. Trenell, Gráinne S. Gorman,
BackgroundCardiac hypertrophic remodelling and systolic dysfunction are common in patients with mitochondrial disease and independent predictors of morbidity and early mortality. Endurance exercise training improves symptoms and skeletal muscle function, yet cardiac adaptations are unknown.Methods and resultsBefore and after 16-weeks of training, exercise capacity, cardiac magnetic resonance imaging and phosphorus-31 spectroscopy, disease burden, fatigue, quality of life, heart rate variability ( ...
Tópico(s): Cardiomyopathy and Myosin Studies
2013 - Elsevier BV | International Journal of Cardiology
Djordje G. Jakovljević, Kate Hallsworth, Paweł Zalewski, Christian Thoma, Jacek J. Klawe, Christopher P. Day, Julia L. Newton, Michael I. Trenell,
Autonomic dysfunction has been reported in patients with NAFLD (non-alcoholic fatty liver disease) and is associated with clinical presentations. To date, there are no therapies to improve autonomic regulation in people with NAFLD. The present study defines the impact of a short-term exercise programme on cardiac autonomic and haemodynamic regulation in patients with NAFLD. A total of 17 patients with clinically defined NAFLD [age, 55±12 years; BMI (body mass index), 33±5 kg/m2; liver fat, 17±9%] were ...
Tópico(s): Cardiovascular Function and Risk Factors
2013 - Portland Press | Clinical Science
Bernard Escudier, Robert J. Motzer, Padmanee Sharma, John Wagstaff, Elizabeth R. Plimack, Hans J. Hammers, Frede Donskov, Howard Gurney, Jeffrey A. Sosman, Paweł Zalewski, Ulrika Harmenberg, David F. McDermott, Toni K. Choueiri, Martin Eduardo Richardet, Yoshihiko Tomita, Alain Ravaud, Justin Doan, Huanyu Zhao, Hélène Hardy, Saby George,
4509 Background: Immunotherapy response patterns differ from traditional therapies, and pts may benefit from treatment after initial RECIST progression (CCR 2009;15:7412–20). We investigated pts treated beyond progression (TBP) with nivo in study CheckMate 025—nivo vs everolimus (eve) in previously treated pts with aRCC (NCT01668784). Methods: Treatment beyond progression was allowed in pts who had investigator-assessed clinical benefit and tolerated study drug. Pts TBP continued to receive nivo ≥4 wk ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2016 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Sharlene Gill, Yoo‐Joung Ko, C. Cripps, Annie Beaudoin, Sukhbinder Dhesy‐Thind, Muhammad Zulfiqar, Paweł Zalewski, Thuan Do, Pablo Cano, Wendy Yin Han Lam, Scot Dowden, Helene Grassin, John A. Stewart, Malcolm J. Moore,
Purpose The standard of care for second-line therapy in patients with advanced pancreatic cancer after gemcitabine-based therapy is not clearly defined. The CONKO-003 phase III study reported a survival benefit with second-line fluorouracil (FU) and oxaliplatin using the oxaliplatin, folinic acid, and FU (OFF) regimen. 1 PANCREOX was a phase III multicenter trial to evaluate the benefit of FU and oxaliplatin administered as modified FOLFOX6 (mFOLFOX6; infusional fluorouracil, leucovorin, and oxaliplatin) ...
Tópico(s): Renal cell carcinoma treatment
2016 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Mirosław Gozdek, Wojciech Pawliszak, Wojciech Hagner, Paweł Zalewski, Janusz Kowalewski, Domenico Paparella, Thierry Carrel, Lech Anisimowicz, Mariusz Kowalewski,
ObjectivesTo investigate the potential beneficial effects of posterior pericardial drainage in patients undergoing heart surgery.MethodsMultiple online databases and relevant congress proceedings were screened for randomized controlled trials assessing the efficacy and safety of posterior pericardial drainage, defined as posterior pericardiotomy incision, chest tube to posterior pericardium, or both. Primary endpoint was in-hospital/30 days' cardiac tamponade. Secondary endpoints comprised death ...
Tópico(s): Ultrasound in Clinical Applications
2016 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Kim N., Celestia S. Higano, Brent A. Blumenstein, Jean‐Marc Ferrero, James A. Reeves, Susan Feyerabend, Gwénaëlle Gravis, Axel S. Merseburger, Arnulf Stenzl, Andries M. Bergman, Som D. Mukherjee, Paweł Zalewski, Fred Saad, Cindy Jacobs, Martin Gleave, Johann S. de Bono,
Tópico(s): Nuclear Structure and Function
2017 - Elsevier BV | The Lancet Oncology
Bernard Escudier, Robert J. Motzer, Padmanee Sharma, John Wagstaff, Elizabeth R. Plimack, Hans J. Hammers, Frede Donskov, Howard Gurney, Jeffrey A. Sosman, Paweł Zalewski, Ulrika Harmenberg, David F. McDermott, Toni K. Choueiri, Martin Eduardo Richardet, Yoshihiko Tomita, Alain Ravaud, Justin Doan, Huanyu Zhao, Hélène Hardy, Saby George,
Response patterns to nivolumab differ from those seen with other approved targeted therapies. To investigate the efficacy of nivolumab in previously treated patients with advanced renal cell carcinoma who were treated beyond (Response Evaluation Criteria In Solid Tumors) RECIST progression. This was a subgroup analysis of patients treated with nivolumab in the phase 3 CheckMate 025 study. Patients continuing to tolerate therapy and exhibiting investigator-assessed clinical benefit were eligible to ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2017 - Elsevier BV | European Urology
Sławomir Kujawski, Joanna Słomko, Małgorzata Tafil‐Klawe, Monika Zawadka‐Kunikowska, Justyna Szrajda, Julia L. Newton, Paweł Zalewski, Jacek J. Klawe,
Introduction: Firefighters as a profession are required to maintain high levels of attention for prolonged periods. However, total sleep deprivation (TSD) could influence negatively upon performance, particularly when the task is prolonged and repetitive. Purpose: The aim of this study is to examine the influence of TSD on cognitive functioning in a group of firefighters. Subjects and methods: Sixty volunteers who were active male fire brigade officers were examined with a computerized battery test ...
Tópico(s): Occupational Health and Performance
2018 - Dove Medical Press | Neuropsychiatric Disease and Treatment
Sławomir Kujawski, Agnieszka Kujawska, Małgorzata Gajos, Weronika Topka, Radosław Perkowski, Joanna Androsiuk-Perkowska, Julia L. Newton, Paweł Zalewski, Kornelia Kędziora–Kornatowska,
Background: Cognitive reserve is a way of explaining why some individuals with a high degree of brain pathology are without clinical manifestations. In this study, factors related to systemic diseases, body composition, aerobic capacity, past and current behavior were examined and included as predictors of cognitive function. Materials and Methods: 407 subjects (60-88 years old) underwent physical examination and cognitive function assessment [Mini-Mental State Examination (MMSE), Montreal Cognitive ...
Tópico(s): Blood Pressure and Hypertension Studies
2018 - Frontiers Media | Frontiers in Aging Neuroscience
Sophie Cassidy, Vivek Prabhakar Vaidya, David Houghton, Paweł Zalewski, Jelena Seferović, Kate Hallsworth, Guy A. MacGowan, Michael I. Trenell, Djordje G. Jakovljević,
Background: This is the first randomised controlled trial to assess the impact of unsupervised high-intensity interval training on cardiovascular autonomic function in adults with type 2 diabetes. Methods: A total of 22 individuals with type 2 diabetes (age 60 ± 2 years, 17 males) lay in a supine position for 20 min for evaluation of cardiovascular autonomic function, which included (1) time domain measures of heart rate variability, (2) frequency domain measures of heart rate variability and blood pressure ...
Tópico(s): Cardiac Health and Mental Health
2018 - SAGE Publishing | Diabetes and Vascular Disease Research
Joanna Słomko, Monika Zawadka‐Kunikowska, Jacek J. Klawe, M Tafil-Klawe, Julia L. Newton, Paweł Zalewski,
In this study we set out to understand is sleep fragmentation affects the cardiovascular regulation and circadian variability of core body temperature more or less than sleep deprivation. 50 healthy men (age 29.0±3.1 years; BMI 24.3±2.1 kg/m2) participated in a 3-day study that included one adaptative night and one experimental night involving randomization to: sleep deprivation (SD) and sleep fragmentation (SF). The evaluation included hemodynamic parameters, measures of the spectral analysis of heart ...
Tópico(s): Sleep and Work-Related Fatigue
2018 - Institute of Physiology of the Czech Academy of Sciences | Physiological Research
Paweł Zalewski, Joanna Słomko, Monika Zawadka‐Kunikowska,
The majority of chronic diseases are accompanied by symptoms of more or less pronounced dysautonomia, which frequently and noticeably deteriorate the quality of patients' life.Pubmed.Functional disorders in the autonomic nervous system (ANS) require very precise diagnostics; frequently involving several specialists and a number of diagnostic tests.Dysautonomia symptoms are of a very discrete nature and may develop much earlier than symptoms specific for a given chronic disease, significantly influencing ...
Tópico(s): Neurological Disorders and Treatments
2018 - Oxford University Press | British Medical Bulletin
Łukasz Rzepiński, Monika Zawadka‐Kunikowska, Zdzisław Maciejek, Julia L. Newton, Paweł Zalewski,
Background and Objectives: Determining the clinical course of multiple sclerosis (MS) and prediction of long-term disability can be a big challenge. To determine early clinical features of MS, their influence on long-term disability progression, and time to transition from relapsing-remitting MS (RRMS) to secondary progressive MS (SPMS), a cohort of Polish patients was studied. Materials and Methods: We retrospectively evaluated 375 Polish MS patients based on data from available medical records. We ...
Tópico(s): Systemic Sclerosis and Related Diseases
2019 - Multidisciplinary Digital Publishing Institute | Medicina
Georg A. Bjarnason, Jennifer J. Knox, Christian Kollmannsberger, Denis Soulières, D. Scott Ernst, Paweł Zalewski, Christina M. Canil, Eric Winquist, Sébastien J. Hotte, Scott North, Daniel Yick Chin Heng, Robyn Jane Macfarlane, Peter Venner, Anil Kapoor, Aaron R. Hansen, Bernhard J. Eigl, Piotr Czaykowski, Ben Boyd, Lisa Wang, Naveen S. Basappa,
BackgroundSunitinib is administered on a rigid schedule that may not be optimal for all patients. We hypothesised that toxicity-driven dose and schedule changes would optimise drug exposure and outcome for each patient.Materials and methodsIn a phase 2 trial, 117 patients with metastatic clear cell renal cell cancer were started on sunitinib 50 mg/day with the aim to treat for 28 days. Treatment breaks were reduced to 7 days. Sunitinib dose and the number of days on therapy were individualised based ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2019 - Elsevier BV | European Journal of Cancer