Book.
1867 - Gale Group | NCCO BritishPolitics
Brian Thompson, Emily A. Davidson, Wei Liu, Daniel W. Nebert, Elspeth A. Bruford, Hongyu Zhao, Emmanouil T. Dermitzakis, David C. Thompson, Vasilis Vasiliou,
Paired-box (PAX) genes encode a family of highly conserved transcription factors found in vertebrates and invertebrates. PAX proteins are defined by the presence of a ... a homeodomain and/or an octapeptide linker subdivides PAX proteins into four groups. Often termed "master regulators", PAX proteins orchestrate tissue and organ development throughout cell ... function through maintenance of cell identity. Mutations in PAX genes are associated with myriad human diseases (e. ... coloboma, hypothyroidism, acute lymphoblastic leukemia). Transcriptional regulation by PAX proteins is, in part, modulated by expression of ...
Tópico(s): Congenital heart defects research
2020 - Springer Science+Business Media | Human Genetics
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1809 - Gale Group | NCCO Corvey
Wu Yu, Mariette Chartier, Gia Ly, Ari Phanlouvong, Shelby Thomas, Jonathon Weenusk, Nora Murdock, Garry Munro, Jitender Sareen,
PAX-Good Behaviour Game (PAX-GBG) is associated with improved mental health among youth. First Nations community members decided on a whole school approach to facilitate PAX-GBG implementation, by offering intervention training to all ... the 23 school staff from First Nations communities.PAX-GBG is a mental health promotion intervention that ... 2018.We inquired about the participants' perception of PAX-GBG and the whole school approach. We applied ... classified the ideas into major categories.Implementing the PAX-GBG whole school approach improved students' behaviour and ...
Tópico(s): Community Health and Development
2019 - BMJ | BMJ Open
Attributed to William Huskisson.--NUC pre-1956. Book.
0000 - Gale Group | The Making of Modern World
Yasmeen M. Attia, Dina M. El‐Kersh, Reham A. Ammar, Aliaa Adel, Aya Khalil, Hoda Walid, Kirullos Eskander, Mohamed Hamdy, N. Di Reda, Nour Elhoda Mohsen, Ghada M. Al-Toukhy, Mohamed T. Mansour, Mohamed M. Elmazar,
Treatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug resistance complex (MDR-1 or ... ALDH-1 expression and consequently the resistance to PAX both in vitro and in vivo. CUR was ... For in vitro studies, the antiproliferative effect of PAX, CUR, 1,25(OH)2D3 (the active form ... as calcitriol) was determined, each alone and combined (PAX+CUR, PAX+1,25(OH)2D3, and PAX+CUR+1,25(OH)2D3) on MCF-7 ... CUR and/or 1,25(OH)2D3 to PAX showed synergistic cytotoxic interaction on MCF-7 cells. ...
Tópico(s): Nanoparticle-Based Drug Delivery
2019 - Elsevier BV | Chemico-Biological Interactions
1987 - Gale Group | Chatham House Online Part 2
Yu Zhou, Xiaoming Xia, Christopher J. Lingle,
The tremorgenic fungal alkaloid paxilline (PAX) is a commonly used specific inhibitor of the large-conductance, voltage- and Ca2+-dependent BK-type K+ channel. PAX inhibits BK channels by selective interaction with closed states. BK inhibition by PAX is best characterized by the idea that PAX gains access to the channel through the central ... the BK channel, and that only a single PAX molecule can interact with the BK channel at a time. The notion that PAX reaches its binding site via the central cavity ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - National Academy of Sciences | Proceedings of the National Academy of Sciences
National Bureau of Economic Research (NBER)
Tim Stranack, N. Beard, E.C. Muxlow, Stephen J. Franklin, Peter Broderick, R.G.W. Rickcord, Charles Christenson, Charles R. Surnamer, J.C.R. Waldsax, Roger Broad, Terence Prittie, Rory Mcguire,
... friends. Tentative answers on the page after next Pax vobiscum, maybe Mr Begin provides the wrapping for ... compromise for the Liberals - if they want it Pax, please Ulster On the road again Wealth tax ...
1977 - Gale Group | The Economist
Antonio Raffone, Antonio Travaglino, Gabriele Saccone, Massimo Mascolo, Luigi Insabato, Antonio Mollo, Giuseppe De Placido, Fulvio Zullo,
... Gynaecological Oncology guidelines recommend paired box 2 protein ( PAX 2) immunohistochemistry to identify precancerous EH . However, methods ... accuracy are not defined, and the role of PAX 2 in endometrial carcinogenesis is unclear. We aimed to assess: (a) PAX 2 expression throughout endometrial carcinogenesis, from normal endometrium ... endometrial cancer (EC); (b) the diagnostic accuracy of PAX 2 immunohistochemistry in diagnosing precancerous EH , defining criteria ... their inception to July 2018. All studies evaluating PAX 2 immunohistochemistry in normal endometrium, EH , and EC ...
Tópico(s): Reproductive System and Pregnancy
2018 - Informa | Acta Obstetricia Et Gynecologica Scandinavica
James Landale, Anthony Harris, Jon Ashworth, Gillian Bowditch Scotland Correspondent, Nicholas Wood, Political Correspondent, Alan Poole (Chairman), Kevin Eason and Nicholas Wood, Paula Davies, Edward Gorman Ireland Correspondent, Simon Barnes, Jill Sherman Political Correspondent, Tim Judah, Peter Fiddick, Angela MacKay, Jeremy Laurance, Social Services Correspondent, Philip Howard, Wendy Vaizey, Michael Binyon, Jeremy Kingston, James Bone, Lynne Truss, David Redhill, Carl Mortished, Alan Duncan, Stuart Jones Football Correspondent, Roddy Forsyth, Bernard Levin, Raphael Eban, Martin Fletcher, Andrew Rowe, Ed Miller, Peter Ball, Debra Craine, Jerry Lloyd, Alison Roberts, Arts Reporter, Martin Barrow, Robin Young, Nicholas Watt, Ann Kent, Philip Robinson, Keith Pike, Charles Bremner, A. Lucas (General Manager), Woodrow Wyatt, Chris Barton, Sarah Bagnall, Aileen Ballantyne, Edward Fennell, Richard Cork, Martin Hoyle, June McKerrow, Director, Anatole Kaletsky, Economics Editor, Barry Millington, Wolfgang Münchau, David Powell Athletics Correspondent, Marcus Binney, Philip Willan, John Phillips and Tim Judah, James D. Zirin, Raymond Keene, Chess Correspondent, Peter Riddell, Political Editor, and Philip Webster, Chief Political Correspondent, Craig Brown, Richard Evans, Nigel Hawkes, W. R. P. George, Peter Riddell and Philip Webster, Barry Pickthall, Michael Evans and Adam Lebor, Roger Boyes, Nigel Hawkes, Science Editor, Brian Beel, David Hands Rugby Correspondent, Ross Tieman Industrial Correspondent, Christopher Walker, N. J. Rosewarne, James Pringle, Matthew Parris, Scrivenor, Robert Seely and Eve-Ann Prentice, Ben MacIntyre, Alan Jabez, Kristin E. Shay, Alan Lee Cricket Correspondent, R. R. Feilden, David Sinclair, Philip Pangalos, Stephen Pettitt, William Cash, Michael Horsnell, Benedict Nightingale, Derek Harris, Frances Gibb Legal Correspondent, Michael Evans Defence Correspondent, Phyllis Vernon, Martin Sweet, Sam Kiley, Vince Wright, Martin Waller Deputy City Editor, R. R. Gye, Michael Spicer, George Sivell City Editor, Tom Walker and Ross Tieman, Christopher Irvine, George Guise,
... Times Diary Clubs not hits The Times Diary Pax on blue plaques The Times Diary A bulwark ... Woodrow Wyatt on the Queen and national identity Pax on blue plaques Labour and Ownership Abolition of ...
1993 - Gale Group | TDA
Jason Harquail, Nicolas LeBlanc, Rodney J. Ouellette, Gilles A. Robichaud,
... cancer progression, such as paired box gene 5 (Pax-5). This transcription factor has consistently been associated ... more recently solid tumors including breast carcinoma. Although Pax-5 downstream activity is relatively well characterized, aberrant Pax-5 expression in a cancer-specific context is poorly understood. To investigate the regulation of Pax-5 expression, we turned to micro RNAs (miRNAs), ... in cancer cells and their putative targeting of Pax-5-dependent cancer processes. Bioinformatic prediction tools indicate ...
Tópico(s): Cancer-related molecular mechanisms research
2018 - Oxford University Press | Carcinogenesis
From Our Own Correspondent, From Our Special Correspondent, From A Polish Correspondent, From Our Correspondent, From Our Military Correspondent, From Our Diplomatic Correspondent, W.H.Mclean., Wickham Steed., Kathleen Hirst, J.A.R.Pimlott., J.T.W., Chrles W.Barber, From A Correspondent, Robertson:,
... Editorials/Leaders: "Fair Attitude!", Death on the Roads, Pax Oceanica, Mr. Fadden's Defeat. Letters to the ...
1941 - Gale Group | TDA
Sami Benzina, Annie‐Pier Beauregard, Roxann Guérrette, Stéphanie Jean, Mame Daro Faye, Mark Laflamme, Emmanuel Maïcas, Nicolas Crapoulet, Rodney J. Ouellette, Gilles A. Robichaud,
Pax-5, an essential transcription factor for B lymphocyte development, has been linked with the development and ... lesions, the specific expression signatures and roles of Pax-5 in breast cancer progression are relatively unknown. ... the present study, we set out to profile Pax-5 expression in mammary tissues and elucidate the cellular and molecular roles of Pax-5 in breast cancer processes. Using immunohistology on mammary tissue arrays, Pax-5 was detected in a total of 298/ ... 6%) samples tested. Interestingly, our studies reveal that Pax-5 inhibits aggressive features and confers anti-proliferative ...
Tópico(s): Cancer-related gene regulation
2017 - Impact Journals LLC | Oncotarget
S.M. Neufeld, Paul H. Frankel, D.A. Bell, J. Spedan Lewis, Andrew Mcfadyean Tenby, Edward S. Reid, Robert P. Shay, Y.H.S. Rich, John Harley,
... Books What Was Decided? A Nation of Peacemakers Pax Americana City of Docks and Drake Secretary-Generalship ...
1957 - Gale Group | The Economist
Célia Dupain, Hafiz Muhammad Ali, Tarik Ait Mouhoub, Giorgia Urbinati, Liliane Massaad-Massade,
TTF-1 and PAX-8 are responsible for thyroid organogenesis and for maintenance of differentiation in thyrocytes. Thus, we hypothesized that the induction ... to modulate expression of the TTF-1 and PAX-8 and their effects on apoptosis were also ... transfected with expression vectors containing TTF-1 or PAX-8 genes. Subsequently, the effects on expression at ... results showed that: i) TTF-1 reciprocally induces PAX-8 expression; ii) the basal state of TTF-1 or PAX-8 influences proliferation, migration and tumorigenicity; iii) the ...
Tópico(s): Cancer Mechanisms and Therapy
2016 - Spandidos Publishing | International Journal of Oncology
Peter Purbeck, F. H. Shera, Eric Blom, A. L. Rowse, Geoffrey Grigson, A. Dudley Grove, Grace Wyndham Goldie, C. H. Middleton, John Gloag, Rev. Leslie Weatherhead, Frank W. Lane, A. S. J. Tessimond, Quintin Riley, Dr. D. A. Spencer, W. E. Williams, Patrick Lacey, T. T. Paterson, Janet Chance, J. M. Keynes, Beatrice King, Alfred Zimmern, M. E. Merrylees, Rt. Hon. Malcolm Macdonald, Professor Percy Ford, Tom Williams, E. M. Forster, Rt. Hon. David Lloyd George, Stanley Casson, Gerald Abraham, Scorpio, John Opie, Arnold J. Toynbee, Rt. Hon. Sir Thomas Inskip, C. H. M.,
... That? Recent Discoveries in Greece The Arctic Today 'Pax Polorum' The Arctic Today A Friendly People Leisure ...
1939 - Gale Group | The Listener GDA
Franziska Anni Franke, Isabell Schumann, Lars Hering, Georg Mayer,
SUMMARY Pax family genes encode a class of transcription factors that regulate various developmental processes. To shed light on ... in Panarthropoda (Onychophora + Tardigrada + Arthropoda), we analyzed the Pax repertoire in the embryonic and adult transcriptomes of ... data revealed homologs of all five major bilaterian Pax subfamilies in this species, including Pax2/5/8, ... Pax3/7. In addition, we identified a new Pax member, pax‐ α , which does not fall into any other known Pax subfamily but instead clusters in the heterogenic Pax‐ ...
Tópico(s): Biocrusts and Microbial Ecology
2015 - Wiley | Evolution & Development
P. Pinhero, Dr. Carl Peters Estates,
... Precaution, The Compensation Court, Failed, An Affable Smuggler, Pax Britannica, England Invaded by Monks, Kimberley's Defender, ...
1901 - Gale Group | NCCO EuropeAfrica
Abha Goyal, Ramya P. Masand, Andres A. Roma,
... profile and origin, we investigated the expression of PAX-8, PAX-2, and GATA binding protein 3 (GATA-3) ( ... in FATWOs. We also studied the expression of PAX-8 and PAX-2 in endometrioid adenocarcinomas; of SF-1 in Sertoli-Leydig cell and SCTs; and of PAX-8, PAX-2, GATA-3, and SF-1 in rete ... Of the FATWOs studied, all were negative for PAX-8, PAX-2, GATA-3, and SF-1. Of the endometrioid adenocarcinomas studied, PAX-8 was positive in all and PAX-2 ...
Tópico(s): Renal and related cancers
2015 - Lippincott Williams & Wilkins | International Journal of Gynecological Pathology