Produção Nacional
Revisado por pares
Luiza Helena Gremski, Fernando Hitomi Matsubara, Hanna Câmara da Justa, Zelinda Schemczssen-Graeff, Antonielle Beatriz Baldissera, Pedro Henrique de Caires Schluga, Isabel de Oliveira Leite, Marianna Bóia-Ferreira, Ana Carolina Martins Wille, Andrea Senff‐Ribeiro, Sílvio Sanches Veiga,
Accidents caused by the bites of brown spiders (Loxosceles) generate a clinical condition that often includes a threatening necrotic skin lesion near the bite site along with a remarkable inflammatory response. Systemic disorders such as hemolysis, thrombocytopenia, and acute renal failure may occur, but are much less frequent than the local damage. It is already known that phospholipases D, highly expressed toxins in Loxosceles venom, can induce most of these injuries. However, this spider venom ...
Tópico(s): Ion channel regulation and function
2021 - BioMed Central | The Journal of venomous animals and toxins including tropical diseases
Produção Nacional
Revisado por pares
Marcel Manente Boiago, Matheus D. Baldissera, Pedro H. Doleski, Nathieli B. Bottari, Guilherme M. do Carmo, Denise Nunes Araújo, Jéssica Giuriatti, Vanessa Baggio, Daniela Bitencourt Rosa Leal, Renata Assis Casagrande, Claudia Salete Wisser, Lenita M. Stefani, Aleksandro Schafer da Silva,
Salmonella Gallinarum is the etiologic agent of fowl typhoid that affects chickens and turkeys causing egg production drops, infertility, lower hatchability, high mortality, and as a consequence severe economic losses to the poultry industry. The alterations in NTPDase and adenosine deaminase (ADA) activities have been demonstrated in several inflammatory conditions; however, there are no data in the literature associated with this infection. Thus, the aim of this study was to evaluate the activities ...
Tópico(s): Herpesvirus Infections and Treatments
2016 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Guerino Bandeira, Águeda Castagna de Vargas, Bernardo Baldisserotto,
The aim of this study was to evaluate the cholinergic (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) and purinergic (adenosine deaminase (ADA)) systems in head kidney, spleen, total blood and serum samples in experimentally infected fish with A. hydrophila, and the involvement of these systems during the inflammatory process. Silver catfish (Rhamdia quelen) juveniles were divided into two groups with seven fish each: uninfected (negative control) and infected (positive control). On day 2 ...
Tópico(s): Parasite Biology and Host Interactions
2016 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Águeda Castagna de Vargas, Marta M.M.F. Duarte, Thiago Duarte, Aline Augusti Boligon, Daniela Bitencourt Rosa Leal, Bernardo Baldisserotto,
Aeromonas hydrophila infection represents a major impediment to the development of aquaculture, leading to important economic losses. Over the last few years, different methods have been used to counteract and minimize the negative effects of this infection, such as the use of Melaleuca alternifolia essential oil, popularly known as tea tree oil (TTO), that possess a bactericide action against A. hydrophila. The purinergic system develops an important role in the inflammatory response, principally ...
Tópico(s): Toxoplasma gondii Research Studies
2017 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Thirssa H. Grando, Michele Rorato Sagrillo, Aleksandro Schafer da Silva, Daniela Bitencourt Rosa Leal, Sílvia González Monteiro,
The aim of this study was to evaluate the enzymatic activity of the purinergic system in sera samples from alloxan-induced diabetic mice treated with tucumã oil (Astrocaryum vulgare). For this, the mice were divided into four groups (n = 6): control/water (the group CW); control/tucumã oil (the group CT); diabetic/water (the group DW), and diabetic/tucumã oil (the group DT) treated for 14 days with 5.0 mL kg−1 via oral gavage. On day 14 post-treatment, mice were submitted to euthanasia and blood samples ...
Tópico(s): Advanced Glycation End Products research
2017 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Revisado por pares
Juliano Assis Baron Engerroff, A.B. Baldissera, Marcelo D. Magalhães, Pedro Lamarão, Paulo A.P. Wendhausen, Carlos H. Ahrens, José Maria Mascheroni,
Isotropic Sm-Fe-N bonded magnets were obtained by additive manufacturing (AM). The technique used was the so-called powder bed fusion (PBF) and the feedstock was composed of a polymeric binder (PA-12) and Sm-Fe-N flake particles (Nitroquench-P). The AM set-up equipment uses a computer-controlled CO2 laser beam to melt the binder and constructs magnets layer-by-layer. In order to develop this study, a cylinder with 10 mm of both height and diameter was selected as the shape of samples. Specimens were ...
Tópico(s): Anatomy and Medical Technology
2019 - Elsevier BV | Journal of Rare Earths
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Karen L.S. Moreira, Maria Izabel de Ugalde Marques da Rocha, Marcelo L. da Veiga, Roberto Christ Vianna Santos, Bernardo Baldisserotto,
Some studies have demonstrated that xanthine oxidase activity, through the regulation of uric acid levels, exerts a pro-inflammatory profile during infectious diseases. It has been recognized that uric acid induces the release of pro-inflammatory mediators, such as reactive oxygen species (ROS) and nitric oxide (NO), which contribute to inflammatory processes. Considering this, the aim of this study was to evaluate whether upregulation of branchial xanthine oxidase activity may be considered a pathway ...
Tópico(s): Paraquat toxicity studies and treatments
2017 - Elsevier BV | Aquaculture
Produção Nacional
Revisado por pares
Giseli Valentini, Joana Neres da Cruz Baldissera, Pedro Patric Pinho Morais, Diego Stähelin, Joice Crescêncio Heidemann, Felipe Stenger, Haroldo Tavares Elias, Altamir Frederico Guidolin, Jefferson Luís Meirelles Coimbra,
O objetivo deste trabalho foi determinar a herança da resistência à murcha de Curtobacterium em feijoeiro. Foram realizados dois experimentos: no primeiro, cinco genótipos de feijoeiro, com diferentes reações de resistência à murcha de Curtobacterium, foram cruzados em arranjo dialélico; e no segundo, dois cruzamentos entre genótipos resistentes e suscetíveis - IAC Carioca Aruã x SCS Guará e IAC Carioca Pyatã x Pérola - foram realizados para dar origem às gerações P1, P2, F1, F2, RC1 e RC2. Em ambos ...
Tópico(s): Plant-Microbe Interactions and Immunity
2011 - Embrapa Informação Tecnológica | Pesquisa Agropecuária Brasileira
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Sílvia González Monteiro, ALEXSANDRO SILVEIRA DA SILVA, Bernardo Baldisserotto,
Abstract Adenosine deaminase ( ADA ) activity, through adenosine (Ado) levels, as well as xanthine oxidase ( XO ) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis . Seric ADA activity decreased, while Ado levels increased in infected ...
Tópico(s): Toxoplasma gondii Research Studies
2017 - Wiley | Journal of Fish Diseases
Produção Nacional
Revisado por pares
Carine F. Souza, Camila Marina Verdi, Matheus D. Baldissera, Pedro H. Doleski, Bruno Stefanello Vizzotto, Roberto Christ Vianna Santos, Bernardo Baldisserotto,
Several pieces of evidence have linked the involvement of xanthine oxidase (XO), a source of uric acid and reactive oxygen species (ROS), to pro-oxidative and pro-inflammatory effects observed during bacterial fish diseases. Thus, the aim of this study was to evaluate whether upregulation of splenic XO activity contributes to disease pathogenesis of Aeromonas caviae infection, as well as whether it may be considered a pathway involved in ROS and nitric oxide (NO) production. XO activity increased in ...
Tópico(s): Toxoplasma gondii Research Studies
2017 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Sílvia Beatriz Alves Rolim, Bijeesh Kozhikkodan Veettil, Antônio Pedro Vieiro, Anita Baldissera Kessler, Clóvis Gonzatti,
Tópico(s): Water Quality Monitoring Technologies
2023 - Springer Science+Business Media | Environmental Science and Pollution Research
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Thirssa H. Grando, Pedro H. Doleski, Aline Augusti Boligon, Lenita M. Stefani, Sílvia González Monteiro,
Tópico(s): Pomegranate: compositions and health benefits
2016 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Produção Nacional
Revisado por pares
Carine F. Souza, Matheus D. Baldissera, Sharine N. Descovi, Carla C. Zeppenfeld, Pedro René Eslava Mocha, Eduardo Micotti da Glória, Régis Adriel Zanette, Bernardo Baldisserotto, Aleksandro Schafer da Silva,
Mycotoxins are secondary metabolites produced by varieties of fungi that contaminate food and feed resources and are capable of inducing a wide range of toxicity. This problem is extensively aggravated due to the increasing replacement of fish meal by plant-derived proteins. Among the mycotoxins, aflatoxins have received a great deal of attention owing to their great prevalence in plant feedstuffs and to the detrimental effects on animals. The objective of this study was to evaluate whether dietary ...
Tópico(s): Bee Products Chemical Analysis
2019 - Elsevier BV | Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Carla C. Zeppenfeld, Sharine N. Descovi, A S Da Silva, Bernardo Baldisserotto,
Several studies have associated the involvement of xanthine oxidase (XO) activity, a source of uric acid and reactive oxygen species (ROS), to pro-oxidative and pro-inflammatory effects during pathological conditions. Considering this, the aim of this study was to evaluate whether upregulation on seric XO activity may be a pathway involved in the oxidative stress in fish exposed to a diet contaminated with aflatoxin B1 (AFB1 ), as well as whether it may be considered a pathway involved in ROS and NOx ...
Tópico(s): Selenium in Biological Systems
2018 - Wiley | Journal of Fish Diseases
Produção Nacional
Revisado por pares
Henrique Fonseca, Remo H.M. Furtado, André Zimerman, Pedro A. Lemos, Marcelo Franken, Frederico Monfardini, Rodrigo Pinto Pedrosa, Rodrigo de Lemos Soares Patriota, Luíz Carlos Santana Passos, Frederico Toledo Campo Dall’Orto, Conrado Roberto Hoffmann Filho, Bruno Ramos Nascimento, Felipe A Baldissera, Cesar Pereira, Paulo Caramori, Pedro Beraldo de Andrade, Carlos Esteves, Elke Ferreira Salim, Jefferson Henrique da Silva, Izabela Pedro, Mariana Castaldi R Silva, Ewerton Hernandes de Pedri, Ana Carla Carioca, Luciana Pereira Almeida de Piano, Camila Santos N Albuquerque, Diogo D.F. Moia, Roberta G.R.A.P. Momesso, Felipe Paiva Machado, Lucas Petri Damiani, Ronaldo Vicente Pereira Soares, Guilherme Schettino, Luiz Vicente Rizzo, José Carlos Nicolau, Otávio Berwanger,
To evaluate whether a strategy of double-dose influenza vaccination during hospitalization for an acute coronary syndrome (ACS) compared with standard-dose outpatient vaccination (as recommended by current guidelines) would further reduce the risk of major cardiopulmonary events.Vaccination against Influenza to Prevent cardiovascular events after Acute Coronary Syndromes (VIP-ACS) was a pragmatic, randomized, multicentre, active-comparator, open-label trial with blinded outcome adjudication comparing ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2022 - Oxford University Press | European Heart Journal
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Karen L.S. Moreira, Marcelo L. da Veiga, Maria Izabel de Ugalde Marques da Rocha, Ana Paula Gottlieb Almeida, Bernardo Baldisserotto,
Studies have demonstrated that fish are able to mount protective immune responses against various parasites, including Ichthyophthirius multifiliis, an economically important protozoosis in freshwater aquaculture. Although the immune response against this parasite have been partly elucidated in the literature, the involvement of the cholinergic and adenosinergic systems, through the anti-inflammatory molecules acetylcholine (ACh) and adenosine (Ado), has not been studied. Thus, the aim of this study ...
Tópico(s): Parasite Biology and Host Interactions
2017 - Elsevier BV | Aquaculture
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Roberto Christ Vianna Santos, Renata Platcheck Raffin, Bernardo Baldisserotto,
Abstract Nanoencapsulated Melaleuca alternifolia essential oil (tea tree oil, TTO ) is a natural alternative treatment, with 100% therapeutic efficacy in fish experimentally infected with Pseudomonas aeruginosa , and has also potent protective effects linked with antioxidant properties. However, the pathways responsible for the antioxidant capacity remain unknown. Thus, this study evaluated whether the inhibition of seric xanthine oxidase ( XO ) activity can be considered a pathway involved in the antioxidant ...
Tópico(s): Bee Products Chemical Analysis
2018 - Wiley | Journal of Fish Diseases
Produção Nacional
Revisado por pares
Carine F. Souza, Matheus D. Baldissera, Sharine N. Descovi, Pedro René Eslava Mocha, Carla C. Zeppenfeld, Eduardo Micotti da Glória, Bernardo Baldisserotto, Aleksandro S. Da Silva,
Aflatoxins are fungal metabolites that contaminate foods and feeds, causing adverse health effects in humans and animals. From an economic standpoint, aflatoxins represent one of the most severe problems for the livestock and feed industries. Currently, natural supplements are used to prevent various fungal infections in farmed fish. The aim of the present study was to determine whether dietary supplementation with tea tree oil (TTO: Melaleuca alternifolia) would prevent or minimize the effects of ...
Tópico(s): Insect and Pesticide Research
2020 - Elsevier BV | Aquaculture
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Daniela Bitencourt Rosa Leal, Lenita M. Stefani, Aline Augusti Boligon, Sílvia González Monteiro,
Tópico(s): Pancreatic function and diabetes
2017 - Springer Science+Business Media | Molecular and Cellular Biochemistry
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Karen L.S. Moreira, Marcelo L. da Veiga, Maria Izabel de Ugalde Marques da Rocha, Roberto Christ Vianna Santos, Bernardo Baldisserotto,
It has been recognized that the cholinergic and adenosinergic systems have an essential role in immune and inflammatory responses during bacterial fish pathogens, such as the enzymes acetylcholinesterase (AChE) and adenosine deaminase (ADA), which are responsible for catalysis of the anti-inflammatory molecules acetylcholine (ACh) and adenosine (Ado) respectively. Thus, the aim of this study was to investigate the involvement of the cholinergic and adenosinergic systems on the immune response and inflammatory ...
Tópico(s): Vagus Nerve Stimulation Research
2017 - Wiley | Journal of Fish Diseases
Produção Nacional
Marizete Elisa Molon, Jefferson Pedro Piva, Patrícia Karcher, Trudiane Baldissera,
In our country, the abstinence syndrome has high prevalence and besides the distress prolongs the length of hospital stay. The aim of this study was to evaluate the influence of associating oral clonidine to the intravenous morphine plus midazolam continuous infusion in children submitted to mechanical ventilation.Randomized, double blind, placebo controlled study, conducted in the PICU at the Hospital Geral of Caxias do Sul. All children (1-36 months) submitted to mechanical ventilation over 12 ...
Tópico(s): Family and Patient Care in Intensive Care Units
2007 - Associação de Medicina Intensiva Brasileira | Revista Brasileira de Terapia Intensiva
Peder L. Myhre, Irene Grundvold, Trine Hessevik Paulsen, Torbjørn Omland, Henrik Schirmer,
... Dall'Orto F, Hoffmann Filho C, Nascimento B, Baldissera F, Pereira C, Caramori P, de Andrade P, Esteves C, Salim E, da Silva J, Pedro I, Silva M, de Pedri E, Carioca A, ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2020 - Lippincott Williams & Wilkins | Circulation
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Naiara S. Guarda, Rafael Noal Moresco, Roberto Christ Vianna Santos, Bernardo Baldisserotto,
Appropriate control of immune responses is a critical determinant of fish health. The cholinergic and adenosinergic systems have important roles in the immune response, since acetylcholine (ACh) and adenosine (Ado) possess important anti-inflammatory properties and modulate the immune response during infectious diseases. Thus, the aim of this study was to evaluate whether splenic and lymphocytic adenosinergic and cholinergic systems are able to modulate the immune response during Pseudomonas aeruginosa ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2017 - Elsevier BV | Aquaculture
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Antônio Francisco Igor Magalhães de Matos, Pedro H. Doleski, Bernardo Baldisserotto, Aleksandro S. Da Silva, Sílvia González Monteiro,
Several evidences have related the biochemical and pharmacological properties of thymol, but the possible neurotoxic effects of this compound remain unknown and not evaluated. Thus, the purpose of this study was to evaluate whether intake of thymol in different doses (10, 20 and 40 mg/kg) induce neurotoxicity and behavioral alterations using mice as experimental model, as well as the involvement of blood-brain barrier (BBB) and brain neurotransmitters in these alterations. Thymol (20 and 40 mg/kg) ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2018 - Elsevier BV | Environmental Toxicology and Pharmacology
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Ricardo E. Mendes, Pedro H. Doleski, Nathieli B. Bottari, Émerson André Casali, César Eduardo Jacintho Moritz, Valesca Veiga Cardoso, Luan Cleber Henker, Ricardo Christ, Fernanda A. Stedille, Lenita M. Stefani, Aleksandro S. Da Silva,
Tópico(s): Parasites and Host Interactions
2016 - Springer Science+Business Media | Parasitology Research
Produção Nacional
Revisado por pares
Chrystian J. Cazarotto, Jhonatan P. Boito, Roger R. Gebert, João H. Reis, Gustavo Machado, Nathieli B. Bottari, Vera Maria Morsch, Maria Rosa Chitolina Schetinger, Pedro H. Doleski, Marta L.R. Leal, Matheus D. Baldissera, Aleksandro S. Da Silva,
The aim of this study was to evaluate the metaphylactic effect of minerals on immunological and antioxidant responses, as well as performance and prevention of coccidiosis in newborn lambs. We divided 110 newborn lambs into two groups (55/group): control (untreated) and treated with two doses of 0.33 mL/kg of a mineral complex (zinc, copper, selenium, and manganese) on day of life (DOL) 1 and 30. Total blood was collected at DOL 1, 15, 30 and 45 to measure antioxidant enzymes, biochemical and immunology ...
Tópico(s): Helminth infection and control
2018 - Elsevier BV | Research in Veterinary Science
Produção Nacional
Leiri Daiane Barli, Naine Martins do Vale, Pedro Patric Pinho Morais, Joana Neres da Cruz Baldissera, Carmelice Boff de Almeida, Fabiani da Rocha, Giseli Valentini, Juliano Garcia Bertoldo, Jefferson Luís Meirelles Coimbra, Altamir Frederico Guidolin,
This study aimed to identify which is the main component of grain yield of bean that that shows less sensitivity effect of the environment, and provides greater consistency in the expression of results when evaluated in different environments. Experimental data used in the analysis are derived from test of Cultivate and Use Value (VCU) conducted in Lages SC and Chapecó SC, South of Brazil. Thecharacters observed were the final stand of plants, number of pods per plant; number of grains per pod, seed ...
Tópico(s): Banana Cultivation and Research
2011 - UNIVERSIDADE ESTADUAL DE LONDRINA | Semina Ciências Agrárias
Produção Nacional
Revisado por pares
G. Baldissera, Nathalia Sperotto, Helen Taís da Rosa, Jeferson Gustavo Henn, Valéria Flores Péres, Dinara Jaqueline Moura, Rafael Roehrs, Elton Luís Gasparotto Denardin, Pedro Dal Lago, Ramiro Barcos Nunes, Jenifer Saffi,
The leaves of Syzygium cumini (L.) or Skeels (Myrtaceae) are widely used in Brazilian folk medicine to treat diabetes. The present study evaluated the functional capacity, biochemical parameters, oxidative stress and DNA damage from eight weeks of intervention with a crude hydroalcoholic extract of S. cumini leaves (EBH) and continuous aerobic training (TAC) in diabetic (D) rats. A hydroalcoholic (50%) extract was prepared by ultrasound and phytochemical parameters (total phenols, total tannins and myricetin ...
Tópico(s): Bee Products Chemical Analysis
2016 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Caroll Schneider Cezarotto, Ariane Dorneles, Fernanda Giesel Baldissera, Matheus Brasil da Silva, Melissa Medeiros Markoski, Luiz Carlos Rodrigues, Alessandra Peres, Tiago Fazolo, Sérgio Augusto de Loreto Bordignon, Miriam Anders Apel, Pedro Roosevelt Torres Romão, Gilsane Lino von Poser,
Several species of Salvia are used as medicinal plants around the world. Biological activities of isolated compounds have been described, being diterpenes frequently responsible for the effects.Isolation of diterpenes from Salvia uliginosa Benth. and evaluation of the antichemotactic and leishmanicidal activities of the isolated compounds.To isolate diterpenes from S. uliginosa and evaluate their antichemotactic and leishmanicidal activities in vitro.The exudate of S. uliginosa was obtained by rapidly ...
Tópico(s): Plant biochemistry and biosynthesis
2018 - Elsevier BV | Phytomedicine
Produção Nacional
Revisado por pares
Matheus D. Baldissera, Carine F. Souza, Thirssa H. Grando, Michele Rorato Sagrillo, Gerson Fernandes de Brum, Kátia Nascimento, Diulle Spat Peres, Miriãn F. Maciel, Sérgio Oliveira Silveira, Sônia Cristina Almeida da Luz, Pedro H. Doleski, Daniela Bitencourt Rosa Leal, Aleksandro S. Da Silva, Sílvia González Monteiro,
Tópico(s): Ion Transport and Channel Regulation
2016 - Elsevier BV | Environmental Toxicology and Pharmacology