Produção Nacional
Revisado por pares
Tatiana Amabile de Campos, Laura Fernandes Gonçalves, Kelly Grace Magalhães, Vicente de Paulo Martins, Georgios Joannis Pappas Júnior, Gisele Peirano, Johann Pitout, Guilherme Bartolomeu Gonçalves, João Pedro Rueda Furlan, Eliana Guedes Stehling, André Pitondo‐Silva,
We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60-70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed ...
Tópico(s): Mycobacterium research and diagnosis
2018 - Frontiers Media | Frontiers in Medicine
Produção Nacional
Revisado por pares
Guilherme Bartolomeu Gonçalves, João Pedro Rueda Furlan, Eliana Carolina Vespero, Marsileni Pelisson, Eliana Guedes Stehling, André Pitondo‐Silva,
Klebsiella pneumoniae is among the most important pathogens found in hospitals. The emergence of multiple antibiotic resistant K. pneumoniae associated with its virulence factors is a worldwide concern and its early identification is crucial, especially for controlling the spread of emerging clones. This article reports a high prevalence of multiresistant K. pneumoniae in a university hospital in southern Brazil, harboring several virulence and β-lactamase encoding genes, including pandrug-resistant ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2017 - Elsevier BV | Infection Genetics and Evolution
Raúl F. Bartolomeu, Pedro Miguel Monteiro Rodrigues, Catarina C. Santos, Mário J. Costa, Tiago M. Barbosa,
The different characteristics of the four swimming strokes affect the interplay between the four limbs, acting as a constraint to the force produced by each hand and foot. The purpose of this study was to analyze the symmetry of force production with a varying number of limbs in action and see its effect on velocity. Fifteen male swimmers performed four all-out bouts of 25-m swims in the four strokes in full-body stroke and segmental actions. A differential pressure system was used to measure the ...
Tópico(s): Muscle activation and electromyography studies
2021 - Multidisciplinary Digital Publishing Institute | Symmetry
Maria Bartolomeu, Márcia Braz, Pedro Costa, João Duarte, Carla Pereira, Adelaide Almeida,
To help halt the global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appropriate disinfection techniques are required. Over the last years, the interest in Ultraviolet-C (UV-C) radiation as a method to disinfect inanimate surfaces and personal protective equipment (PPE) has increased, mainly to efficiently disinfect and prevent SARS-CoV-2 from spreading and allow for the safe reuse of said equipment. The bacteriophage ϕ6 (or simply phage ϕ6) is an RNA virus with a phospholipid ...
Tópico(s): COVID-19 impact on air quality
2022 - Multidisciplinary Digital Publishing Institute | Microorganisms
Produção Nacional
Revisado por pares
Wallace J. Reis, Ícaro A. O. Bozzi, Matheus Ribeiro, Priscila Cristina Bartolomeu Halicki, Laís A. Ferreira, Pedro Eduardo Almeida da Silva, Daniela Fernandes Ramos, Carlos A. de Simone, Eufrânio N. da Silva Júnior,
Isoniazid-naphthoquinone hybrids were synthesized and evaluated against a susceptible (H37Rv) strain and two isoniazid-resistant strains (INHR1 and INHR2) of Mycobacterium tuberculosis. The antimycobacterial activity of the derivatives was determined based on the resazurin microtiter assay and their cytotoxicity in adhered mouse monocyte macrophage J774.A1 cells (ATCC TIB-67). Of the twenty-two compounds evaluated against the three strains of M. tuberculosis, twenty-one presented some activity against ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2019 - Elsevier BV | Bioorganic & Medicinal Chemistry
Produção Nacional
Revisado por pares
Acarília Eduardo Silva, Elquio Eleamen Oliveira, Monique Christine Salgado Gomes, Henrique Rodrigues Marcelino, Karen C. Holanda Silva, Bartolomeu Santos Souza, Toshiyuki Nagashima, Alejandro Pedro Ayala, Anselmo Gomes de Oliveira, Eryvaldo Sócrates Tabosa do Egito,
Xylan is a biopolymer found in a variety of cell wall plants. Eudragit® S-100 (ES100), a pH-dependent polymer, is used as a coating material in gastroresistant delivery systems. In this study, microparticles based on both polymers were produced by interfacial cross-linking polymerisation and/or spray-drying technique in order to investigate feasibility and stability of the systems. Size and morphology of the microparticles were characterised by optical and SEM while FT-IR, thermal analysis (TG/DTA), ...
Tópico(s): Nanocomposite Films for Food Packaging
2013 - Taylor & Francis | Journal of Microencapsulation
José A. Bragada, Raúl F. Bartolomeu, Pedro Miguel Monteiro Rodrigues, Pedro M. Magalhães, João P. Bragada, Jorge E. Morais,
Background: Cardiovascular capacity, expressed as maximal oxygen uptake (VO2max), is a strong predictor of health and fitness and is considered a key measure of physiological function in the healthy adult population. The purpose of this study was to validate a specific step test (StepTest4all) as an adequate procedure to estimate cardiovascular capacity in young adults. Methods: The sample was composed of 56 participants, including 19 women (aged 21.05 ± 2.39 years, body mass = 57.50 ± 6.64 kg, height = 1. ...
Tópico(s): Sports Performance and Training
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Environmental Research and Public Health
Produção Nacional
Revisado por pares
Lélia Pacheco Corrêa Barros, Karina P. Del Rio, Tatiane dos Santos Conceição Carvalho, Maria do Carmo F. R. Pinto, Kelly C. G. de Moura, Priscila Cristina Bartolomeu Halicki, Daniela Fernandes Ramos, Pedro Eduardo Almeida da Silva,
Tuberculosis (TB) is the cause of more than one million deaths worldwide, and despite being a curable disease, some factors can make therapy difficult, emphasizing the need for the development of new drugs that may potentiate the action of the classic anti-TB antimicrobials. Naphthoimidazoles show a broad spectrum of biological activities, including antimycobacterial activity. The aim of this study was to evaluate the anti-Mycobacterium tuberculosis activity of nine naphthoimidazoles, alone and combined ...
Tópico(s): Synthesis and biological activity
2018 - Elsevier BV | Tuberculosis
Produção Nacional
Revisado por pares
Bruna Lisboa Gonçalves, Daniela Fernandes Ramos, Priscila Cristina Bartolomeu Halicki, Pedro Eduardo Almeida da Silva, Juliano Rosa de Menezes Vicenti,
In this paper we report the synthesis and characterization of the following aromatic hydroxamates: potassium(I) benzohydroxamate (BZH), potassium(I) nitrobenzohydroxamate (N-BZH), potassium(I) dinitrobenzohydroxamate (DN-BZH) and the complexes derived containing zinc(II): BZH-Zn, N-BZH-Zn and DN-BZH-Zn. The compounds were characterized and their probable structures proposed using infrared spectroscopy, nuclear magnetic resonance spectroscopy, thermogravimetry and elemental analysis. Calculations of ...
Tópico(s): Synthesis and biological activity
2019 - Elsevier BV | Chemical Data Collections
G. Miranda, Susana Faria, F. Bartolomeu, E. Pinto, Sara Madeira, Artur Mateus, Pedro Carreira, Nuno Alves, F.S. Silva, Óscar Carvalho,
Tópico(s): Additive Manufacturing and 3D Printing Technologies
2016 - Elsevier BV | Materials Science and Engineering A
Produção Nacional
Revisado por pares
Paola Aparecida Alves Azevedo, João Pedro Rueda Furlan, Guilherme Bartolomeu Gonçalves, Carolina Nogueira Gomes, Rafael da Silva Goulart, Eliana Guedes Stehling, André Pitondo‐Silva,
This study characterised 48 Klebsiella pneumoniae isolates from outpatients with urinary tract infection in the micro-region of Ribeirão Preto, located in southeastern Brazil. The isolates were identified by conventional biochemical and phenotypic tests and were confirmed as K. pneumoniae using a MALDI-TOF VITEK® MS system. Antimicrobial susceptibility testing was performed by the disk diffusion method as recommended by the Clinical and Laboratory Standards Institute (CLSI) using 38 different antibiotic ...
Tópico(s): Urinary Tract Infections Management
2019 - Elsevier BV | Journal of Global Antimicrobial Resistance
Produção Nacional
Revisado por pares
Daniela Fernandes Ramos, Priscila Cristina Bartolomeu Halicki, Carolina da Silva Canielles Caprara, Pedro Borges de Souza, Caroline Da Ros Montes D’Oca, Maria de Fátima Costa Santos, Marcelo G. Montes D’Oca, Fábio Roselet, Pedro Eduardo Almeida da Silva, Paulo César Abreu,
Microalgae, due to its rapid growth, low nutritional requirements, and versatility of adaptation to different environmental conditions, has aroused the biotechnological interest, synthesizing novel molecules with antioxidant, anticoagulant, anti-inflammatory, antitumor, and antimicrobial activities. In this sense, we carried out the bioprospection of Chaetoceros muelleri, a marine diatom employed in aquaculture, as a candidate to the development of new drugs for the treatment of bacterial infections. ...
Tópico(s): Marine Sponges and Natural Products
2022 - Wiley | Chemistry & Biodiversity
Produção Nacional
Revisado por pares
Thelma Shirlen Soares, Hélio Garcia Leite, Antônio Bartolomeu do Vale, Carlos Pedro Boëchat Soares, Gilson Fernandes da Silva,
O objetivo deste estudo foi avaliar o modelo de distribuição diamétrica de passo invariante proposto por Guimarães (1994) na projeção da produção de um povoamento de Eucalyptus sp., simulando as alterações nas estruturas horizontal e vertical ao longo do tempo. Utilizaram-se dados da primeira rotação de povoamentos de eucalipto híbrido estaca (Eucalyptus grandis x Eucalyptus urophylla), plantados no espaçamento 3,0 x 2,0 m, localizados na região noroeste do Estado da Bahia, provenientes de medições ...
Tópico(s): Agricultural and Food Sciences
2007 - Sociedade de Investigações Florestais | Revista Árvore
Produção Nacional
Revisado por pares
Francisco F. de Sousa, Helvio S.A. de Sousa, Alcemira C. Oliveira, M. Cordova C, Alejandro Pedro Ayala, Eduardo B. Barros, Bartolomeu C. Viana, Josué Mendes Filho, Alcinéia C. Oliveira,
Nanostructured Ni-containing spinel oxide catalysts were obtained using a nanocasting method. Analyses by XRD, TEM, TPD-CO2 and TPR showed that Nio and/or Coo entities with high accessibility to CH4 and CO2 were responsible for high catalytic performance in the dry reforming of methane. The NiCo (Coo and Nio dispersed on NiAl2O4) and NiAl (Nio dispersed on NiAl2O4) species were highly active for CH4 conversion, whereas Nio dispersed on either Fe3O4–Co3O4 or CeO2–NiAl2O4 provided a lower catalytic ...
Tópico(s): Catalysis and Oxidation Reactions
2011 - Elsevier BV | International Journal of Hydrogen Energy
Produção Nacional
Revisado por pares
Ênio Roberto Pietra Pedroso, José Roberto Lambertucci, Dirceu Bartolomeu Greco, Manoel Otávio da Costa Rocha, Cid Sérgio Ferreira, Pedro Raso,
A double blind trial was set up to study the pulmonary effects of specific treatment with oxamniquine of 40 patients with chronic schistosomiasis mansoni. Radiological alterations characterized by bronchopneumonitis were seen in 17.5% of the patients after treatment, but in none of the placebo group; non-migratory condensation occurred between 25 and 72 h after treatment, with a mean duration of 7 d. 86% of the patients showed spontaneous healing with no radiological sequelae after 30 d of follow- ...
Tópico(s): Helminth infection and control
1987 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene
Produção Nacional
Revisado por pares
Pedro Rodrigues Torres-Jr, Alberto García-Martínez, Marcelo Bagnulo, Eduardo Parente Ribeiro,
Bartolomeu is a solution to enable stub networks to perform adaptive egress traffic load balancing across multiple interdomain routes by spreading the traffic across available paths according to a passive measurement of their performance. It defines a BGP-SDN architecture that increases the number of BGP routes that can be used by stub networks. Bartolomeu measures the available capacity of each path to any destination prefix, and allocates to each path a number of large flows that is proportional ...
Tópico(s): Network Traffic and Congestion Control
2020 - Elsevier BV | Computer Networks
Produção Nacional
Revisado por pares
Stefhania Alzate Lozano, Aline Bastos Brilhante de Sousa, Julio Cezar de Souza, David Ribeiro da Silva, Marcos Gabriel Maciel Salazar, Priscila Cristina Bartolomeu Halicki, Daniela Fernandes Ramos, Pedro Eduardo Almeida da Silva, Cecília Veronica Núñez,
Abstract Duroia saccifera (Rubiaceae) occurs in the Amazon rainforest and their extracts showed antibacterial properties. To obtain greater quantities of active substances, leaf segments from in vitro D. saccifera seedlings were used as explants for calli induction; calli were multiplied via multiple subcultures, dried and extracted with hexane followed by ethyl acetate (EtOAc) and methanol (MeOH). As D. macrophylla had been reported to produce antimycobacterial substances, we assayed calli extracts ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2020 - Rio de Janeiro Botanical Garden Research Institute | Rodriguésia
Jorge Fontes, Bruno C. L. Macena, S. Solleliet-Ferreira, F. Buyle, R. Magalhães, Tiago Bartolomeu, Nikolai Liebsch, Carl G. Meyer, Pedro Afonso,
Abstract Background Biologging technologies have yielded new insights into the ecology and behaviour of elasmobranchs, but to date, most studies involve animal capture and restraint to attach tags. Capturing animals usually results in a period of atypical behaviour after release and is undesirable or simply not possible for large and vulnerable elasmobranchs such as mobulas and whale sharks. To avoid animal capture and restraint, we developed and tested two non-invasive multisensor towed tags. The ...
Tópico(s): Fish Ecology and Management Studies
2022 - BioMed Central | Animal Biotelemetry
Produção Nacional
Revisado por pares
Priscila Cristina Bartolomeu Halicki, Vanessa Radin, Andréa von Groll, Marcus Vinícius Nora, Alessandra C. Pinheiro, Pedro Eduardo Almeida da Silva, Daniela Fernandes Ramos,
In the last 15 years, Acinetobacter baumannii has received special attention, mainly due to several resistance mechanisms and high rates of morbimortality. The ability to form biofilms contributes to the persistence of this microorganism in the hospital environment and facilitates the occurrence of nosocomial infections. Several studies have highlighted the pharmacological relevance of pyridines in the treatment and control of infectious diseases and others have related the anti-A. baumannii potential ...
Tópico(s): Antimicrobial agents and applications
2019 - Mary Ann Liebert, Inc. | Microbial Drug Resistance
Produção Nacional
Revisado por pares
Dirceu Bartolomeu Greco, Ênio Roberto Pietra Pedroso, José Roberto Lambertucci, Manoel Otávio da Costa Rocha, Paulo Marcos Zech Coelho, Pedro Raso, Cid Sérgio Ferreira,
The post-treatment pulmonary alterations were evaluated in patients (Study 1) and in mice (Study 2) infected with Schistosoma mansoni. Study 1: the patients were examined pre and post-treatment (with ora oxamniquine) and the following exams were performed: sputum for eosinophils and chest x-ray. Study 2: four groups of mice (total = 64) were studied; Group I (infected and treated with oxamniquine); II (infected and not treated); III (not infected and treated) and IV (not infected and not treated). All were ...
Tópico(s): Trypanosoma species research and implications
1987 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Pedro José Gomes Rodrigues, Conceição de Maria Vaz Elias, Bartolomeu C. Viana, Luciana Maria de Hollanda, Thiago Domingues Stocco, Luana Marotta Reis de Vasconcellos, Daphne de Camargo Reis Mello, Francisco Eroni Paz dos Santos, Fernanda Roberta Marciano, Anderson Oliveira Lobo,
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2020 - Springer Nature | Journal of materials research/Pratt's guide to venture capital sources
Produção Nacional
Revisado por pares
Priscila Cristina Bartolomeu Halicki, Gabriela Hädrich, Raphael Aparecido Boschero, Laís A. Ferreira, Andréa von Groll, Pedro Eduardo Almeida da Silva, Cristiana Lima Dora, Daniela Fernandes Ramos,
Tuberculosis (TB) is considered an emergency global public health, mainly due to the TB-HIV co-infection, bacillus dormancy stage, and emergence of resistant strains. In addition, the therapeutic toxicity and its pharmacokinetic interactions with other drugs may influence treatment non-compliance, low serum concentration of drugs, and, consequently, treatment failure. Strategies using nanotechnology represent a new tool for the therapy, since they are effective delivery systems due to the possibility ...
Tópico(s): Tuberculosis Research and Epidemiology
2018 - Mary Ann Liebert, Inc. | Assay and Drug Development Technologies
Produção Nacional
Revisado por pares
Miguel Matos, João Almeida, Pedro Gonçalves, Fabiano Baldo, Fernando José Braz, Paulo Bartolomeu,
The energy sector is currently undergoing a significant shift, driven by the growing integration of renewable energy sources and the decentralization of electricity markets, which are now extending into local communities. This transformation highlights the pivotal role of prosumers within these markets, and as a result, the concept of Renewable Energy Communities is gaining traction, empowering their members to curtail reliance on non-renewable energy sources by facilitating local energy generation, ...
Tópico(s): Energy Efficiency and Management
2024 - Multidisciplinary Digital Publishing Institute | Energies
Produção Nacional
Revisado por pares
Betânia Maira Pontelo, Dirceu Bartolomeu Greco, Nathália Sernizon Guimarães, Nina Rotsen, Victor Alberto Rebelo Braga, Pedro Henrique Nogueira Pimentel, Hugo Perazzo Pedroso Barbosa, Taciane Miranda Barroso, Unaí Tupinambás,
HIV infection may be considered a chronic condition for people living with HIV with access to antiretrovirals and this has effectively increased survival. Moreover, this has also facilitated the emergence of other comorbidities increasing the risk for drug–drug interactions and polypharmacy. The profile of these interactions as well as their consequences for people living with HIV are still not completely elucidated. The objectives of this study were to describe the profile of these interactions, ...
Tópico(s): HIV/AIDS Research and Interventions
2020 - Elsevier BV | The Brazilian Journal of Infectious Diseases
... As igrejas colegiadas de Santiago e de S. Bartolomeu, as igrejas de Santa Justa, de S. Pedro e de S. João de Almedina, o mosteiro ...
Tópico(s): Religious Tourism and Spaces
2016 - Coimbra University Press | Revista de História da Sociedade e da Cultura
Produção Nacional
Revisado por pares
Priscila Cristina Bartolomeu Halicki, Laís A. Ferreira, Kelly C. G. de Moura, Paula F. Carneiro, Karina P. Del Rio, Tatiane dos Santos Conceição Carvalho, Maria do C. F. R. Pinto, Pedro E. A. da Silva, Daniela Fernandes Ramos,
Despite being a curable disease, tuberculosis (TB) remains a public health problem worldwide mainly due to lengthy treatment, as well as its toxic effects, TB/HIV co-infection and the emergence of resistant Mycobacterium tuberculosis strains. These barriers reinforcing the need for development of new antimicrobial agents, that ideally should reduce the time of treatment and be active against susceptible and resistant strains. Quinones are compounds found in natural sources and among them, the naphthoquinones ...
Tópico(s): Synthesis and biological activity
2018 - Frontiers Media | Frontiers in Microbiology
Jayme Neves, Ênio Roberto Pietra Pedroso, Fernando Oréfice, Dirceu Wagner Carvalho de Souza, Dirceu Bartolomeu Greco, Manoel Otávio da Costa Rocha, Pedro Raso,
Os Autores descrevem um caso grave de esquistossomose mansoni numa criança de 9 anos de idade (forma hepática com hipertensão portai associada a forma pulmonar com hipertensão pulmonar e cor pulmonale) clinicamente caracterizado por episódios de insuficiência respiratória desencadeados em face de esforços físicos moderados. Sucessivos exames radiológicos de tórax revelaram comprometimento predominantemente arteriolar ao iado de uma micronodulação delicada e difusamente distribuída e configuração ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
1980 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Produção Nacional
Revisado por pares
Ivy Bastos Ramis, Ricardo G. Figueiredo, Daniela Fernandes Ramos, Priscila Cristina Bartolomeu Halicki, Andréa von Groll, Miguel Viveiros, Maria do Céu Costa, Pedro E. A. da Silva,
Mycobacterium abscessus causes a wide range of clinical diseases that are difficult to treat. This microorganism is resistant not only to the classical antituberculosis agents but also to most of the antimicrobials that are currently available, resulting in limited therapeutic options and treatment failure. This scenario stresses the need to search for new drugs with activity against M. abscessus.To evaluate in vitro the antimycobacterial activity and cytotoxicity of rifabutin (RFB 1) and ten derivatives ( ...
Tópico(s): Cancer therapeutics and mechanisms
2017 - Bentham Science Publishers | Medicinal Chemistry
Produção Nacional
Revisado por pares
Júlia Silveira Vianna, Ivy Bastos Ramis, Priscila Cristina Bartolomeu Halicki, Otávio Leite Gastal, Renato Azevedo da Silva, José Salomão, Deise Machado dos Santos, Ana Lucia Hentsch Chaves, Carlos Renan Varela Juliano, Heitor Alberto Jannke, Lande Vieira da Silva, Andréa von Groll, Pedro Eduardo Almeida da Silva,
CagA of Helicobacter pylori undergoes tyrosine phosphorylation in a region containing differing numbers of repeat sequences (EPIYAs), which can result in a modulation of the inflammatory response. This study investigated whether the presence of CagA EPIYA variations in strains of H. pylori that are positive for this region contributes to differing degrees of disease severity in the gastric mucosa. In this study, 157 H. pylori–positive patients were included, and of those, 40.8% (64/157) were infected ...
Tópico(s): Gastrointestinal disorders and treatments
2015 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Raúl F. Bartolomeu, Pedro Rodrigues, Kamil Sokołowski, Marek Strzała, Catarina C. Santos, Mário J. Costa, Tiago M. Barbosa,
Human locomotion on water depends on the force produced by the swimmer to propel the body forward. Performance of highly complex motor tasks like swimming can yield minor variations that only nonlinear analysis can be sensitive enough to detect. The purpose of the present study was to examine the nonlinear properties of the hand/feet forces and describe their variations across the four competitive swimming strokes performing segmental and full-body swimming. Swimmers performed all-out bouts of 25 ...
Tópico(s): Muscle activation and electromyography studies
2023 - De Gruyter Open | Journal of Human Kinetics