Andrew Robson, Matthew Syed, Andrew Pierce, DJM, George Crawford, Qpm Retired Chief Superindent, Simon Barnes, Peter Lansley, Mark Souster, Nick Hawton, Michael Evans Defence Editor, Philip Howard, Hilary Finch, David Chater, James Ducker, Penny Wark, Lorna Blackwood, Liz Hodgkinson, Colin Fuller, Carol Sarler, Richard Irving, Catherine Riley Property Editor, Matthew Hoggard, Sam Marlowe, James Hider, William Hague, Geoff Brown, Gerald Davies, Sam Lister, Andrew Norfolk, Tom Proudfoot, Paul Hodgetts, David McVay, Dr Andrew Bamji, Stewart Tendler Crime Correspondent, Jack Malvern, Tom Bawden, Dominic Walsh, Dan Sabbagh Media Editor, James Doran Wall Street Correspondent, Mike Pattenden, lan Johns, Caroline Merrell Banking correspondent, Jill Dupleix, Dan Sabbagh, Ruth Gledhill Religion Correspondent, Alan Hamilton, Benedict Le Vay, Richard Lloyd Parry, David Hands, Adam LeBor, Charles Bremner and Graham Keeley, Jane Martin, Ron Lewis, Matt Dickinson Chief Football Correspondent, Stefanie Marsh, Richard Beeston, Catherine Philp and Michael Theodoulou, David Charter, Matthew Pinsent, Hugo Rifkind, Russell Kempson, Don Sabbagh, Ingrid Mansell and Dominic Walsh, Mary Gold, Daniel McGrory, Nicole Swengley, Gary Duncan Economics Editor, Oliver Kay, Gerard Baker, Patrick Hosking Investment Editor, Pete Paphides, Ann Treneman, Rob Wright, Gabriel Rozenberg, Marcus Binney, Raymond Keene, Vaughan Freeman, Lucia Adams, Chris Fox President of the Assoation, Lewis Smith, Amanda Holloway, Matt Hughes, Christine Buckley Industrial Editor, Joe Morgan and Antonia Senior, Rosemary Bennett Deputy Political Editor, Peta Bee, Chris Campling, Patrick Hosking, Christopher Martin-Jenkins Chief Cricket Correspondent, Mick Hume, Nick Hasell, Nick Brook, Andrew Jack, Tony Cascarino, Tom Dart, Paul Simons, Sir David Durie Chairman, Steve Jelbert, Nick Szczepanik, Nell Harman Tennis Correspondent, Jane Shilling, Brian MacArthur, Dr Brain Curwain, Mel Webb, Dominic Maxwell, Ashling O'connor, Jeremy Page and Anthony Browne, Graham Searjeant Financial Editor, Morris Le Fleming, David Crossland, Frank Greaney, George Caulkin, Russell Jenkins, Peter Thornton, Neil Fisher, Alan Lee, Susan McDonald, Patrick Murray, Anthony Loyd, Peter Riddell, Ben MacIntyre, Alice King, Antonia Senior and Rebecca O'Connor, Clare Chapman and Lewis Smith, Rajeev Syal, Lucia van der Post, David Sanderson, Catherine Philp, Martin Waller, Lisa Verrico, Sarah Butler, Ashling O'Connor, Benedict Nightingale, Angus Batey, Alexandra Blair and Philip Webster, Dr Thomas Stuttaford, Stephen Dalton, Ben Hoyle, Richard Morrison, Owen Slot, Olav Bjortomt, Andrew Riley, Jenny Davey, Peter Klinger, Peter Light, Sam Lister Health Correspondent, Patience Wheatcroft, Christopher Irvine, Raekha Prasad,
... Fed's new man DLA Piper Rudnick Gray Cary New team for Ethel Austin Burberry Demerger Payout ...
2005 - Gale Group | TDA
Dorbea Cary, Pedro Carmona Marques,
Abstract Abstract The cultural competency of mental-health professionals is crucial to the provision of necessary and appropriate services to an increasingly multicultural clientele. In a clinical setting, supervisors and supervisees must form a partnership to pursue cultural competency. Through working together, they can use their cultural awareness, knowledge, and skills to benefit the diverse clientele. In this article, the authors share their experiences from teaching a 2-day workshop about ...
2007 - Haworth Press | The Clinical Supervisor
Cary Twyman, Pedro Oyuela, Jeffrey Palmer, David Margolin, Colin Dayan,
OBJECTIVE: Summarize incidence and timing of thyroid autoimmune adverse events (AEs) in the ongoing CARE-MS extension study (as of July 15, 2013). BACKGROUND: Three clinical trials (CAMMS223, CARE-MS I, and CARE-MS II) in active relapsing-remitting multiple sclerosis (RRMS) patients demonstrated superior clinical efficacy for alemtuzumab versus subcutaneous interferon beta-1a (SC IFNB-1a); efficacy improvements were sustained in the first additional year of the CARE-MS extension phase. Alemtuzumab’s ...
Tópico(s): Liver Diseases and Immunity
2014 - Lippincott Williams & Wilkins | Neurology
Francisco Cary, Octavian Postolache, Pedro Silva Girão,
Abstract This paper describes a framework focused on being a health monitoring platform as well as a source of entertainment for physiotherapy patients, particularly stroke survivors. Using the Microsoft Kinect sensor a serious game captures 3D data during the patient’s session and sends it to a server. Through a web application these data can be further visualized by the physiotherapists on their assessments. Moreover, this framework intends to be a useful and effective tool for remote physiotherapy ...
Tópico(s): Virtual Reality Applications and Impacts
2014 - Exeley Inc | International Journal on Smart Sensing and Intelligent Systems
Laura Surace, Jean‐Marc Doisne, Carys A. Croft, Anna Thaller, Pedro Escoll, Solenne Marie, Natalia Petrosemoli, Vincent Guillemot, Valérie Dardalhon, Davide Topazio, Antonia Cama, Carmen Buchrieser, Naomi Taylor, Ido Amit, Olimpia Musumeci, James P. Di Santo,
Abstract Group 2 innate lymphoid cells (ILC2s) represent innate homologs of type 2 helper T cells (T H 2) that participate in immune defense and tissue homeostasis through production of type 2 cytokines. While T lymphocytes metabolically adapt to microenvironmental changes, knowledge of human ILC2 metabolism is limited, and its key regulators are unknown. Here, we show that circulating ‘naive’ ILC2s have an unexpected metabolic profile with a higher level of oxidative phosphorylation (OXPHOS) than natural ...
Tópico(s): Eosinophilic Esophagitis
2021 - Nature Portfolio | Nature Immunology
Pedro Belda‐Ferre, James C. Williamson, Áurea Simón‐Soro, Alejandro Artacho, Ole N. Jensen, Álex Mira,
Tooth decay is considered the most prevalent human disease worldwide. We present the first metaproteomic study of the oral biofilm, using different mass spectrometry approaches that have allowed us to quantify individual peptides in healthy and caries-bearing individuals. A total of 7771 bacterial and 853 human proteins were identified in 17 individuals, which provide the first available protein repertoire of human dental plaque. Actinomyces and Coryneybacterium represent a large proportion of the ...
Tópico(s): Dental Health and Care Utilization
2015 - Wiley | PROTEOMICS
Christina King‐Smith, Pedro Paz, Cary W. Lee, Winnie Wing‐Chuen Lam, Beth Burnside,
In the teleost retinal pigment epithelium (RPE), melanin pigment granules disperse into long apical projections in the light and reaggregate into the cell body in the dark. To investigate the cytoskeletal mechanisms responsible for these movements, we have examined the effects of cytoskeletal inhibitors on pigment granule transport in cultured, dissociated RPE cells using time-lapse video microscopy. The kinetics of pigment granule transport during normal aggregation and dispersion are quite distinct: ...
Tópico(s): Cellular transport and secretion
1997 - Wiley | Cell Motility and the Cytoskeleton
Jomar Diaz-Nicolas, María Guadalupe Silva, Sona Rivas‐Tumanyan, Milagros J Toro, Augusto R Elías-Boneta,
... study was to estimate the prevalence of dental caries in schoolattending 12-year-olds in San Pedro de Macoris, Dominican Republic. Methods: A cross-sectional epidemiological study using a probabilistic sample, stratified by type of school (public/private) and gender, was conducted. Two calibrated examiners conducted the evaluations of oral soft/hard tissues. Caries experience was summarized in terms of prevalence; the ...
Tópico(s): Dental Research and COVID-19
2020 - University of Puerto Rico | Puerto Rico health sciences journal

Omid Talakoub, Raquel R. Paiva, Matija Milosevic, Marcelo Q. Hoexter, Ruth Rocha Franco, Eduardo Joaquim Lopes Alho, Jessie Navarro, José F. Pereira, Miloš R. Popović, Cary R. Savage, Antônio Carlos Lopes, Pedro Gomes de Alvarenga, Durval Damiani, Manoel J. Teixeira, Eurípedes C. Miguel, Erich Talamoni Fonoff, Marcelo C. Batistuzzo, Clement Hamani,
Abstract Lateral hypothalamic area ( LHA ) local field potentials ( LFP s) were recorded in a Prader–Willi patient undergoing deep brain stimulation ( DBS ) for obesity. During hunger, exposure to food‐related cues induced an increase in beta/low‐gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha‐frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued ...
Tópico(s): Neuroscience of respiration and sleep
2017 - Wiley | Annals of Clinical and Translational Neurology
Adriana Rego, Francisco Raio, Teresa P. Martins, Hugo Ribeiro, António G. G. Sousa, Joana Séneca, Mafalda S. Baptista, Charles K. Lee, S. Craig Cary, Vítor Ramos, Maria F. Carvalho, Pedro N. Leão, Catarina Magalhães,
Bacterial diversity from McMurdo Dry Valleys in Antarctica, the coldest desert on earth, has become more easily assessed with the development of High Throughput Sequencing (HTS) techniques. However, some of the diversity remains inaccessible by the power of sequencing. In this study, we combine cultivation and HTS techniques to survey actinobacteria and cyanobacteria diversity along different soil and endolithic micro-environments of Victoria Valley in McMurdo Dry Valleys. Our results demonstrate ...
Tópico(s): Protist diversity and phylogeny
2019 - Frontiers Media | Frontiers in Microbiology
Pedro Luiz Rosalen, W.H. Bowen, S.K. Pearson,
The purpose of the present study was to explore the effects of varying levels of copper incorporated in sucrose by co-crystallization on caries development in the desalivated rat model and to examine the retention of copper in the oral cavity and its influence on protein and carbohydrate composition of plaque. Forty-eight Sprague-Dawley rats were infected by Streptococcus sobrinus 6715 and desalivated when aged 26 days. Four groups were placed in a König-Höfer programmed feeder and received 17 meals ...
Tópico(s): Molecular Biology Techniques and Applications
1996 - Karger Publishers | Caries Research
Áurea Simón‐Soro, Pedro Belda‐Ferre, Raúl Cabrera‐Rubio, Luis David Alcaraz, Álex Mira,
Current understanding of dental caries considers this disease a demineralization of the tooth tissues due to the acid produced by sugar-fermenting microorganisms. Thus, caries is considered a diet- and pH-dependent process. We present here the first metagenomic analysis of the bacterial communities present at different stages of caries development, with the aim of determining whether the bacterial composition and biochemical profile are specific to the tissue affected. The data show that microbial ...
Tópico(s): Endodontics and Root Canal Treatments
2013 - Karger Publishers | Caries Research

Ana Paula Pires dos Santos, Vera Mendes Soviero,
... this study was to assess the prevalence of caries and risk factors in outpatients of the Pediatric Ambulatory of the Pedro Ernesto University Hospital aging up to 36 months. After signing informed consent forms, the parents answered a structured questionnaire in order to evaluate risk factors for dental caries, including socioeconomic status, oral hygiene and dietary habits. ...
Tópico(s): Dental Health and Care Utilization
2002 - UNIVERSIDADE DE SÃO PAULO | Pesquisa Odontológica Brasileira
Edward Fox, Douglas L. Arnold, Jeffrey Cohen, Alasdair Coles, Christian Confavreux, Hans Hartung, Eva Havrdová, Krzysztof Selmaj, Howard L. Weiner, Cary Twyman, Anton Vladić, David Margolin, Pedro Oyuela, Michael Panzara, Alastair Compston,
OBJECTIVE: To examine durability of alemtuzumab9s efficacy in relapsing-remitting multiple sclerosis (RRMS) patients who participated in the pivotal phase 3 CARE-MS trials and continued in the extension study. BACKGROUND: Two 2-year phase 3 trials comparing alemtuzumab to subcutaneous interferon beta-1a in RRMS patients who were treatment naive (CARE-MS I) and who had relapsed on prior therapy (CARE-MS II) found significant positive treatment effects for alemtuzumab on relapses (both studies) and accumulation ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2013 - Lippincott Williams & Wilkins | Neurology

Carolina Bosso André, Pedro Luiz Rosalen, Lívia Câmara de Carvalho Galvão, Bruna Marin Fronza, Gláucia María Bovi Ambrosano, Jack L. Ferracane, Marcelo Giannini,
The aim of this in vitro study was to analyze the effect of the incorporation of two anti-caries agents into dental adhesives on the reduction of the virulence of Streptococcus mutans and on the adhesion to dentin. Apigenin (1 mM) and tt-Farnesol (5 mM) were added separately and in combination to a self-etch adhesive (CS3 — Clearfil S3 Bond Plus) and to an each-and-rinse adhesive (OPT — OptiBond S). Biofilm of S. mutans was grown on adhesive-coated hydroxyapatite disks for 115 h and bacterial viability, ...
Tópico(s): Endodontics and Root Canal Treatments
2017 - Elsevier BV | Dental Materials

Gabriela Fernanda Bombarda, Pedro Luiz Rosalen, Éder Ramos Paganini, Mayara A R Garcia, Diego Romário Silva, Josy Goldoni Lazarini, Irlan Almeida Freires, Luís Octávio Regasini, Janaina C O Sardi,
Aim: To evaluate antimicrobial activity of a new nitrochalcone (NC-E08) against Candida albicans and Streptococcus mutans, and its toxicity. Materials & methods: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration/minimum fungicidal concentration (MFC) were determined against C. albicans and S. mutans, as well as antibiofilm potential and toxicity (human gingival fibroblast and Galleria mellonella). Infection and treatment were performed in G. mellonella. Results & conclusion: ...
Tópico(s): Bacterial biofilms and quorum sensing
2019 - Future Medicine | Future Microbiology

Lívia Câmara de Carvalho Galvão, Pedro Luiz Rosalen, Isamar Rivera-Ramos, Gilson César Nobre Franco, Jessica K. Kajfasz, Jacqueline Abranches, Bruno Bueno‐Silva, H. Koo, José A. Lemos,
In oral biofilms, the major environmental challenges encountered by Streptococcus mutans are acid and oxidative stresses. Previously, we showed that the transcriptional regulators SpxA1 and SpxA2 are involved in general stress survival of S. mutans with SpxA1 playing a primary role in activation of antioxidant and detoxification strategies whereas SpxA2 serves as a back up activator of oxidative stress genes. We have also found that spxA1 mutant strains (∆spxA1 and ∆spxA1∆spxA2) are outcompeted by ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2016 - Wiley | Molecular Oral Microbiology

Simone Duarte, Pedro Luiz Rosalen, Mitsue Fujimaki, Jaime Aparecido Cury, William H. Bowen, Robert E. Marquis, Vera Lúcia Garcia Rehder, Adilson Sartoratto, Masaharu Ikegaki, Hyun Koo,
A flavonoids-free Brazilian propolis (type 6) showed biological effects against mutans streptococci and inhibited the activity of glucosyltransferases. This study evaluated the influence of the ethanolic extract of a novel type of propolis (EEP) and its purified hexane fraction (EEH) on mutans streptococci biofilms and the development of dental caries in rats. The chemical composition of the propolis extracts were examined by gas chromatography/mass spectrometry. The effects of EEP and EEH on Streptococcus ...
Tópico(s): Oral microbiology and periodontitis research
2005 - Elsevier BV | Archives of Oral Biology

H. Koo, Pedro Luiz Rosalen, Jaime Aparecido Cury, Y.K. Park, Masaharu Ikegaki, Aroni Sattler,
The purpose of the present study was to evaluate the effect of Apis mellifera propolis collected from two regions of Brazil on caries development in desalivated rats. Ethanolic extracts of propolis (EEP) were prepared from crude propolis samples collected in Minas Gerais state (MG), southeastern Brazil, and Rio Grande do Sul state (RS), southern Brazil. The flavonoid composition of EEP was analyzed by high–performance thin–layer chromatography (HPTLC) and reversed–phase high–performance liquid chromatography ( ...
Tópico(s): Insect and Pesticide Research
1999 - Karger Publishers | Caries Research
Pedro Luiz Rosalen, W.H. Bowen, S.K. Pearson,
Previous studies have shown that fluoride (F) administered concomitantly with sucrose in drinking water, in the diet, or alone is an effective cariostatic agent. The purpose of the present study was to determine the minimum concentration of F co-cystallized with sugar that may be used to prevent dental caries in rats subjected to a severe cariogenic challenge. Desalivated Sprague-Dawley rats, infected with Streptococcus sobrinus, were placed in a König-Hf̈er programmed feeder. The rats received 17 ...
Tópico(s): Dental Health and Care Utilization
1997 - Elsevier BV | Archives of Oral Biology

Mitsue Fujimaki, Hyun Koo, Pedro Luiz Rosalen, Simone Duarte, Eliane Melo Franco, William H. Bowen, Masaharu Ikegaki, Jaime Aparecido Cury,
Recently, two chemically different types of Brazilian propolis (type-3 and -12) were shown to have cariostatic properties. This study aimed to evaluate the influence of their isolated fractions on mutans streptococci viability, glucosyltransferases (GTFs) activity and caries development in rats. The ethanolic extracts of propolis (EEPs) were serially fractionated into hexane (H-fr), chloroform, ethyl acetate, and ethanol. The ability of the four fractions and EEP to inhibit Streptococcus mutans and Streptococcus ...
Tópico(s): Microencapsulation and Drying Processes
2005 - Elsevier BV | Journal of Ethnopharmacology
Pedro Luiz Rosalen, S.K. Pearson, W.H. Bowen,
The purpose was to explore the effects of combinations of copper, iron and fluoride (Cu, Fe and F) incorporated in sucrose by co-crystallization on caries development in the desalivated rat model and to examine acid formation by bacteria in the rat mouth. Ninety-six Sprague-Dawley rats were infected with Streptococcus sobrinus 6715 and desalivated when aged 26 days. Eight groups were placed in a König-Höfer programmed feeder and received 17 meals daily at hourly intervals, and essential nutrition ( ...
Tópico(s): Endodontics and Root Canal Treatments
1996 - Elsevier BV | Archives of Oral Biology

Marlise I. Klein, K. Scott‐Anne, Stacy Gregoire, Pedro Luiz Rosalen, H. Koo,
Summary Culturing methods are the primary approach for microbiological analysis of plaque biofilms in rodent models of dental caries. In this study, we developed strategies for the isolation of DNA and RNA from plaque biofilms formed in vivo to analyse the viable bacterial population and gene expression. Plaque biofilm samples from rats were treated with propidium monoazide to isolate DNA from viable cells, and the purified DNA was used to quantify total bacteria and the Streptococcus mutans population ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2012 - Wiley | Molecular Oral Microbiology

Jae‐Gyu Jeon, Pedro Luiz Rosalen, Megan L. Falsetta, Hyun Koo,
Dental caries is the most prevalent and costly oral infectious disease worldwide. Virulent biofilms firmly attached to tooth surfaces are prime biological factors associated with this disease. The formation of an exopolysaccharide-rich biofilm matrix, acidification of the milieu and persistent low pH at the tooth-biofilm interface are major controlling virulence factors that modulate dental caries pathogenesis. Each one offers a selective therapeutic target for prevention. Although fluoride, delivered ...
Tópico(s): Endodontics and Root Canal Treatments
2011 - Karger Publishers | Caries Research

Antônio Pedro Ricomini-Filho, Bertha Angélica CHÁVEZ, Rodrigo A. Giacaman, Paulo Frazão, Jaime Aparecido Cury,
Dental caries remains highly prevalent in Latin American and Caribbean countries (LACC). However, this disease can be controlled through interventions that implement evidence-based strategies in an affordable manner and that target all population groups instead of the most affluent only. Therefore, the aim of this report was to summarize the main scientifically documented community interventions and strategies based on restriction of sugars consumption, use of fluoride, and the use of occlusal sealants ...
Tópico(s): Dental Erosion and Treatment
2021 - Brazilian Society of Dental Research | Brazilian Oral Research
Laura Surace, Jean‐Marc Doisne, Pedro Escoll, Solenne Marie, Valérie Dardalhon, Carys A. Croft, Anna Thaller, Davide Topazio, Angelo Sparaneo, Antonia Cama, Olimpia Musumeci, Aurelio D’Ecclesia, Carmen Buchrieser, Naomi Taylor, James P. Di Santo,
Distinct metabolic demands accompany lymphocyte differentiation into short-lived effector and long-lived memory cells. How bioenergetics processes are structured in innate natural killer (NK) cells remains unclear. We demonstrate that circulating human CD56Dim (NKDim) cells have fused mitochondria and enhanced metabolism compared with CD56Br (NKBr) cells. Upon activation, these 2 subsets showed a dichotomous response, with further mitochondrial potentiation in NKBr cells vs paradoxical mitochondrial ...
Tópico(s): Microgrid Control and Optimization
2020 - Elsevier BV | Blood Advances

Bennett T. Amaechi, Lívia Maria Andaló Tenuta, Antônio Pedro Ricomini-Filho, Jaime Aparecido Cury,
Caries lesions result from the interaction between dental biofilm and sugars. Since the biofilm is an important component in the etiology of the disease, biofilm models have been developed to study the cariogenicity of dietary sugars, as well as the anticaries effect of substances. Two of such models, termed as "static" or "continuous flow," are described in details here together with their advantages, limitations, and applications.
Tópico(s): Dental materials and restorations
2019 - Springer Science+Business Media | Methods in molecular biology

Pedro Alves Filho, Ricardo Ventura Santos, Mário Vianna Vettore,
This ecological study investigated the association between social and environmental inequities and dental caries among indigenous people in Brazil. Dental caries data were gathered from articles identified from electronic databases for the period between 2000 and 2007. Independent variables were obtained from the census of Health Information System for Sanitation Indigenous Populations. Multiple linear regression analysis was conducted to test the association between social and environmental characteristics ...
Tópico(s): Dental Health and Care Utilization
2013 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Revista Brasileira de Epidemiologia
Jordi Martínez-Gomis, Alejandro Fernández-Solanas, Miguel Viñas, Pedro A. González, M. Planas, S. Fernández,
Four groups of rats were inoculated with Streptococcus sobrinus ATCC 33478 and fed a cariogenic diet for 42 days. Topical treatment with either distilled water, sodium fluoride (0.2%), a solution containing lactoferrin and lactoperoxidase, or a solution containing liposome-encapsulated lactoferrin and liposome-encapsulated lactoperoxidase was applied at intervals for 35 days. Caries incidence in groups treated with liposome-encapsulated lactoferrin and lactoperoxidase was significantly lower than ...
Tópico(s): Neonatal and Maternal Infections
1999 - Elsevier BV | Archives of Oral Biology

Pedro Da‐Gloria, Rodrigo Elias Oliveira, Walter Alves Neves,
The origin and dispersion of the first Americans have been extensively investigated from morphological and genetic perspectives, but few studies have focused on their health and lifestyle. The archaeological site of Lapa do Santo, central-eastern Brazil, has exceptionally preserved Early Holocene human skeletons, providing 19 individuals with 327 permanent and 122 deciduous teeth dated to 9,250 to 7,500 years BP. In this study, we test whether the inhabitants of Lapa do Santo had high prevalence ...
Tópico(s): Archaeology and ancient environmental studies
2017 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências