Produção Nacional
Revisado por pares
Castelo Pedro Vemba Cidade, Marcele Jardim Pimentel, Regiane Cristina do Amaral, Mauro Antônio de Arruda Nóbilo, José Ricardo de Albergaría Barbosa,
Conventional tilted implants are used in oral rehabilitation for heavily absorbed maxilla to avoid bone grafts; however, few research studies evaluate the biomechanical behavior when different angulations of the implants are used. The aim of this study was evaluate, trough photoelastic method, two different angulations and length of the cantilever in fixed implant-supported maxillary complete dentures. Two groups were evaluated: G15 (distal tilted implants 15°) and G35 (distal tilted implants 35°) ...
Tópico(s): Dental materials and restorations
2014 - Brazilian Society of Dental Research | Brazilian Oral Research
Inês Faleiro, Ricardo Leão, Alexandra Binnie, Ramon Andrade de Mello, Ana-Teresa Maia, Pedro Castelo‐Branco,
... 3 , Ana-Teresa Maia 1,2,3 and Pedro Castelo-Branco 1,2,3 1 Regenerative Medicine Program, ... of Medicine, University of Coimbra, Portugal Correspondence to: Pedro Castelo-Branco, email: // Keywords : epigenetic therapy, urologic cancers, clinical ...
Tópico(s): Cancer-related gene regulation
2016 - Impact Journals LLC | Oncotarget
Pedro Castelo‐Branco, Ricardo Leão, Tatiana Lipman, Brittany Campbell, Dong‐Hyun Lee, Aryeh J. Price, Cindy Zhang, Abolfazl Heidari, Derek Stephens, Stefan Boerno, Hugo Coelho, Ana Gomes, Célia Domingos, Joana Apolónio, Georg Schäfer, Robert G. Bristow, Michal R. Schweiger, Robert J. Hamilton, Alexandre R. Zlotta, Arnaldo Figueiredo, Helmut Klocker, Holger Sültmann, Uri Tabori,
// Pedro Castelo-Branco 1, 2, 3, * , Ricardo Leão 1, 4, 5, * , Tatiana Lipman 1 , Brittany Campbell 1 , Donghyun ... to: Uri Tabori, email: uri.tabori@sickkids.ca Pedro Castelo-Branco, email: pjbranco@ualg.pt Keywords: TERT, prostate ...
Tópico(s): Telomeres, Telomerase, and Senescence
2016 - Impact Journals LLC | Oncotarget
Produção Nacional
Ramon Andrade de Mello, Carles Escriu, Pedro Castelo‐Branco, Paloma Cabral, Giannis Mountzios, Gilberto Lopes, Pedro Madureira,
... Mello 1, 2, 3 , Carles Escriu 4, 5 , Pedro Castelo-Branco 1, 2, 6 , Paloma Lucena Cabral 7 , Giannis Mountzios 8 , Gilberto de Lima Lopes 9 and Pedro Madureira 10 1 Division of Oncology, School of ...
Tópico(s): Colorectal Cancer Treatments and Studies
2017 - Impact Journals LLC | Oncotarget
Luís Campos, B. Parada, F. Furriel, D. Castelo, Pedro Moreira, A. Mota,
To assess the importance of intraoperative management of recipient hemodynamics for immediate versus delayed graft function.The retrospective study of 1966 consecutive renal transplants performed in our department between June 1980 and December 2009 analyzed several perioperative hemodynamic factors: central venous pressure (CVP), mean arterial pressure (MAP) as well as volumes of fluids, fresh frozen plasma (FFP), albumin, and whole blood transfusions. We examined their influence on renal graft function ...
Tópico(s): Renal and Vascular Pathologies
2012 - Elsevier BV | Transplantation Proceedings
Produção Nacional
Revisado por pares
Adauto Castelo, Pedro A. Mathiasi, Roberto F. Iunes, Afrânio Lineu Kritski, Margareth Pretti Dalcolmo, Fernando Fiúza de Melo, Michael Drummond,
Tópico(s): Immunodeficiency and Autoimmune Disorders
1995 - Adis, Springer Healthcare | PharmacoEconomics
Produção Nacional
Revisado por pares
Dalva Neves da Costa Bento, Marise Reis de Freitas, Artur da Silveira Pinto,
... localidades situadas na área rural dos municípios de Castelo do Piauí e Pedro II, Estado do Piauí, Brasil. O estádio de ...
Tópico(s): Vector-borne infectious diseases
1989 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Pedro Silva, Jorge Castelo, Pedro Santos,
O nível competitivo alcançado pelo futebol profissional tem exigido níveis de desempenho cada vez mais elevados. Uma das formas que tem sido utilizada para monitorá-la é a análise do jogo (AJ). O presente trabalho pretendeu caracterizar o processo de AJ na 1ª liga portuguesa profissional de futebol. Os objetivos do estudo foram conhecer: 1) a importância da AJ; 2) a frequência da sua realização; 3) os profissionais envolvidos; 4) os instrumentos e métodos utilizados; e 5) a importância atribuída ...
Tópico(s): Physical Education and Pedagogy
2011 - School of Physical Education and Sports - USP | Revista Brasileira de Educação Física e Esporte
Paulo A. Augusto, Teresa Castelo-Grande, Pedro Augusto,
None of the present magnetic separators is capable of achieving the classification of particles according to their magnetic susceptibility. We have developed a new apparatus to attain these magnetic classification goals. In this paper, the design of the continuous-mode large-scale prototype of the magnetic classifier is presented. Many areas of application are foreseen for this device, and we analyse two of them – health sciences and chemical engineering – presenting also some possible application cases ...
Tópico(s): Earthquake Detection and Analysis
2005 - Elsevier BV | Chemical Engineering Journal
Produção Nacional
Revisado por pares
Christina Wyss Castelo Branco, Pedro Américo Cabral Senna,
Tópico(s): Aquatic Ecosystems and Biodiversity
1996 - Springer Science+Business Media | Hydrobiologia
Christina Wyss Castelo Branco, Pedro Américo Cabral Senna,
Tópico(s): Fish biology, ecology, and behavior
1996 - | Algological Studies/Archiv für Hydrobiologie Supplement Volumes
Miguel Castelo‐Branco, Pedro Faria, V. Forjaz, Lajos R. Kozák, H. Azevedo,
To use a new methodological approach, based on luminance noise, to assess without bias the relative damage of blue-yellow and red-green pathways in ocular hypertension and glaucoma and to correlate obtained measurements with clinical markers of disease progression.A psychophysical procedure modified from Cambridge color test was used to assess color discrimination in three different groups: patients with primary open-angle glaucoma (n = 51 eyes), patients with ocular hypertension (n = 95 eyes), and control ...
Tópico(s): Ophthalmology and Visual Impairment Studies
2004 - Cadmus Press | Investigative Ophthalmology & Visual Science
Brent J. Passer, Pedro Castelo‐Branco, Jason S. Buhrman, Sarah Varghese, Samuel D. Rabkin, R L Martuza,
Tópico(s): Cancer Research and Treatments
2009 - Springer Nature | Cancer Gene Therapy
Christina Wyss Castelo Branco, Pedro Américo Cabral Senna,
Tópico(s): Fish Biology and Ecology Studies
1991 - | Bulletin du Jardin botanique national de Belgique / Bulletin van de National Plantentuin van België
Carlos Zagalo, José Martins dos Santos, Nuno Grande, N.A. Castelo Branco, Pedro Oliveira,
Low frequency noise (LFN) (>_ 90 dB SPL, <_ 500 Hz) is an agent of disease that regularly goes unchecked during standard noise assessment procedures. Vibroacoustic disease (VAD) is an extra-aural noise-induced systemic pathology, caused by long-term exposure to LFN and characterised by a proliferation of extra-cellular matrices. The present study attempts to elucidate the behaviour of medium-and larg e - c a l i b re blood vessels in the presence of insult due to noise and vibration. Thirty-five adult Wistar ...
Tópico(s): Biomarkers in Disease Mechanisms
2002 - | European Journal of Anatomy
Ta‐Chiang Liu, Pedro Castelo‐Branco, Samuel D. Rabkin, Robert L. Martuza,
Oncolytic herpes simplex viruses (HSVs) possess direct oncolytic and antiangiogenic activities and are promising anticancer agents, but their efficacy, when used as single agents, leaves room for improvement. We investigated whether combination therapy of HSV with histone deacetylase inhibitor trichostatin A (TSA), an agent that also targets cancer cells and tumor vasculature, would result in enhanced efficacy. In vitro, TSA and G47Δ showed strong synergy of action against proliferating endothelial ...
Tópico(s): RNA Interference and Gene Delivery
2008 - Elsevier BV | Molecular Therapy
Pedro Castelo‐Branco, Brent J. Passer, Jason S. Buhrman, Slawomir J. Antoszczyk, M Marinelli, Cécile Zaupa, Samuel D. Rabkin, R L Martuza,
Prostate cancer is one of the most prevalent cancers in men. Replication-competent oncolytic herpes simplex virus (oHSV) vectors are a powerful antitumor therapy that can exert at least two effects: direct cytocidal activity that selectively kills cancer cells and induction of antitumor immunity. In addition, oHSV vectors can also function as a platform to deliver transgenes of interest. In these studies, we have examined the expression of a xenogeneic homologue of the prostate cancer antigen, prostatic ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2010 - Springer Nature | Gene Therapy
Erin J. Walker, Cindy Zhang, Pedro Castelo‐Branco, Cynthia Hawkins, Wesley V. Wilson, Nataliya Zhukova, Noa Alon, Ana Novokmet, Berivan Baskin, Peter N. Ray, Christiane B. Knobbe‐Thomsen, Peter B. Dirks, Michael D. Taylor, Sidney Croul, David Malkin, Uri Tabori,
Abstract Although monoallelic expression (MAE) is a frequent genomic event in normal tissues, its role in tumorigenesis remains unclear. Here we carried out single-nucleotide polymorphism arrays on DNA and RNA from a large cohort of pediatric and adult brain tumor tissues to determine the genome-wide rate of MAE, its role in specific cancer-related genes, and the clinical consequences of MAE in brain tumors. We also used targeted genotyping to examine the role of tumor-related genes in brain tumor ...
Tópico(s): MicroRNA in disease regulation
2011 - American Association for Cancer Research | Cancer Research
Pedro Castelo‐Branco, Cindy Zhang, Tatiana Lipman, Mayumi Fujitani, Loen M. Hansford, Ian D. Clarke, Calvin B. Harley, Robert Tressler, David Malkin, Erin J. Walker, David R. Kaplan, Peter B. Dirks, Uri Tabori,
Abstract Purpose: Cancer recurrence is one of the major setbacks in oncology. Maintaining telomeres is essential for sustaining the limitless replicative potential of such cancers. Because telomerase is thought to be active in all tumor cells and normal stem cells, telomerase inhibition may be nonspecific and have detrimental effects on tissue maintenance and development by affecting normal stem cell self-renewal. Methods: We examined telomerase activity, telomere maintenance, and stem cell maturation ...
Tópico(s): Cancer Cells and Metastasis
2011 - American Association for Cancer Research | Clinical Cancer Research
Jeremy Schwartzentruber, Andrey Korshunov, Xiao-Yang Liu, David Jones, Elke Pfaff, Karine Jacob, Dominik Sturm, Adam M. Fontebasso, Dong-Anh Khuong Quang, Martje Tönjes, Volker Hovestadt, Steffen Albrecht, Marcel Kool, André Nantel, Carolin Konermann, Anders M. Lindroth, Natalie Jäger, Tobias Rausch, Marina Ryzhova, Jan O. Korbel, Thomas Hielscher, Péter Hauser, Miklós Garami, Álmos Klekner, László Bognár, Martin Ebinger, Martin U. Schuhmann, Wolfram Scheurlen, Arnulf Pekrun, Michael C. Frühwald, Wolfgang Roggendorf, Christoph Kramm, Matthias Dürken, Jeffrey R. Atkinson, Pierre Lepage, Alexandre Montpetit, Magdalena Zakrzewska, Krzysztof Zakrzewski, Paweł P. Liberski, Zhifeng Dong, Peter M. Siegel, Andreas E. Kulozik, Marc Zapatka, Abhijit Guha, David Malkin, Jörg Felsberg, Guido Reifenberger, Andreas von Deimling, Koichi Ichimura, V. Peter Collins, Hendrik Witt, Till Milde, Olaf Witt, Cindy Zhang, Pedro Castelo‐Branco, Peter Lichter, Damien Faury, Uri Tabori, Christoph Plass, Jacek Majewski, Stefan M. Pfister, Nada Jabado,
Nature 482, 226–231 (2012) Sequence reads for paediatric glioblastoma multiforme (GBM) samples have been deposited in the European Genome Archive under the accession number EGAS00001000226. This has been corrected in the HTML and PDF versions online.
Tópico(s): MicroRNA in disease regulation
2012 - Nature Portfolio | Nature
Jeremy Schwartzentruber, Andrey Korshunov, Xiao-Yang Liu, David Jones, Elke Pfaff, Karine Jacob, Dominik Sturm, Adam M. Fontebasso, Dong-Anh Khuong Quang, Martje Tönjes, Volker Hovestadt, Steffen Albrecht, Marcel Kool, André Nantel, Carolin Konermann, Anders M. Lindroth, Natalie Jäger, Tobias Rausch, Marina Ryzhova, Jan O. Korbel, Thomas Hielscher, Péter Hauser, Miklós Garami, Álmos Klekner, László Bognár, Martin Ebinger, Martin U. Schuhmann, Wolfram Scheurlen, Arnulf Pekrun, Michael C. Frühwald, Wolfgang Roggendorf, Christoph Kramm, Matthias Dürken, Jeffrey Atkinson, Pierre Lepage, Alexandre Montpetit, Magdalena Zakrzewska, Krzysztof Zakrzewski, Paweł P. Liberski, Zhifeng Dong, Peter M. Siegel, Andreas E. Kulozik, Marc Zapatka, Abhijit Guha, David Malkin, Jörg Felsberg, Guido Reifenberger, Andreas von Deimling, Koichi Ichimura, V. Peter Collins, Hendrik Witt, Till Milde, Olaf Witt, Cindy Zhang, Pedro Castelo‐Branco, Peter Lichter, Damien Faury, Uri Tabori, Christoph Plass, Jacek Majewski, Stefan M. Pfister, Nada Jabado,
Tópico(s): Epigenetics and DNA Methylation
2012 - Nature Portfolio | Nature
Pedro Castelo‐Branco, André Furger, Matthew Wollerton, Christopher W. J. Smith, Alexandra Moreira, Nicholas Proudfoot,
Polypyrimidine tract binding protein (PTB) is a major hnRNP protein with multiple roles in mRNA metabolism, including regulation of alternative splicing and internal ribosome entry site-driven translation.We show here that a fourfold overexpression of PTB results in a 75% reduction of mRNA levels produced from transfected gene constructs with different polyadenylation signals (pA signals).This effect is due to the reduced efficiency of mRNA 3 end cleavage, and in vitro analysis reveals that PTB competes ...
Tópico(s): RNA modifications and cancer
2004 - Taylor & Francis | Molecular and Cellular Biology
Joshua Mangerel, Aryeh J. Price, Pedro Castelo‐Branco, Jack Brzezinski, Pawel Buczkowicz, Patricia Rakopoulos, Diana M. Merino, Berivan Baskin, Jonathan D. Wasserman, Matthew Mistry, Mark Barszczyk, Daniel Picard, Stephen C. Mack, Marc Remke, Hava Starkman, Cynthia Elizabeth, Cindy Zhang, Noa Alon, Jodi Lees, Irene L. Andrulis, Jay S. Wunder, Nada Jabado, Donna L. Johnston, James T. Rutka, Peter B. Dirks, Éric Bouffet, Michael D. Taylor, Annie Huang, David Malkin, Cynthia Hawkins, Uri Tabori,
Tópico(s): Ocular Oncology and Treatments
2014 - Springer Science+Business Media | Acta Neuropathologica
Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, Dianna C. Martin, Pedro Castelo‐Branco, Cindy H. Zhang, Michael Fraser, Ken Tse, Raymond Poon, David Shih, Berivan Baskin, Peter N. Ray, Éric Bouffet, Peter B. Dirks, André O. von Bueren, Elke Pfaff, Andrey Korshunov, David Jones, Paul A. Northcott, Marcel Kool, Trevor J. Pugh, Scott L. Pomeroy, Yoon-Jae Cho, Torsten Pietsch, Marco Gessi, Stefan Rutkowski, László Bognár, Byung-Kyu Cho, Charles G. Eberhart, Cécile Faure‐Conter, Maryam Fouladi, Pim J. French, Wiesława Grajkowska, Nalin Gupta, Péter Hauser, Nada Jabado, Alexandre Vasiljevic, Shin Jung, Seung-Ki Kim, Álmos Klekner, Toshihiro Kumabe, Bolesław Lach, Jeffrey R. Leonard, Linda M. Liau, Luca Massimi, Ian F. Pollack, Young Shin, Joshua B. Rubin, Erwin G. Van Meir, Kyu‐Chang Wang, William A. Weiss, Karel Zitterbart, Robert G. Bristow, Benjamin A. Alman, Cynthia Hawkins, David Malkin, Steven C. Clifford, Stefan M. Pfister, Michael D. Taylor, Uri Tabori,
TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or mutant human medulloblastoma cell-lines and normal neural stem cells were used to test ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2014 - Springer Science+Business Media | Acta Neuropathologica Communications
Pawel Buczkowicz, Christine M. Hoeman, Patricia Rakopoulos, Sanja Pajovic, Louis Létourneau, Misko Dzamba, Andrew Morrison, Peter W. Lewis, Éric Bouffet, Ute Bartels, Jennifer Zuccaro, Sameer Agnihotri, Scott Ryall, Mark Barszczyk, Yevgen Chornenkyy, Mathieu Bourgey, Guillaume Bourque, Alexandre Montpetit, Francisco J. Cordero, Pedro Castelo‐Branco, Joshua Mangerel, Uri Tabori, King Ching Ho, Annie Huang, Kathryn R. Taylor, Alan Mackay, Anne Bendel, Javad Nazarian, Jason Fangusaro, Matthias A. Karajannis, David Zagzag, Nicholas K. Foreman, Andrew M. Donson, Julia Hegert, Amy Smith, Jennifer A. Chan, Lucy Lafay-Cousin, Sandra E. Dunn, Juliette Hukin, Christopher Dunham, Katrin Scheinemann, Jean Michaud, Shayna Zelcer, David A. Ramsay, Jason E. Cain, Cameron Brennan, Mark M. Souweidane, Chris Jones, C. David Allis, Michael Brudno, Oren J. Becher, Cynthia Hawkins,
Cynthia Hawkins, Oren Becher and colleagues report the identification of recurrent mutations in ACVR1 in 20% of diffuse intrinsic pontine gliomas. Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children, with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and to the selection of therapies on the basis of assumptions that DIPGs are molecularly similar to adult disease. ...
Tópico(s): Renal and related cancers
2014 - Nature Portfolio | Nature Genetics
Mark Barszczyk, Pawel Buczkowicz, Pedro Castelo‐Branco, Stephen C. Mack, Vijay Ramaswamy, Joshua Mangerel, Sameer Agnihotri, Marc Remke, Brian Golbourn, Sanja Pajovic, Cynthia Elizabeth, Man Yu, Betty Luu, Andrew Morrison, Jennifer Adamski, Kathleen Nethery-Brokx, Xiao‐Nan Li, Timothy Van Meter, Peter B. Dirks, James T. Rutka, Michael D. Taylor, Uri Tabori, Cynthia Hawkins,
Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor from which they are identified, and are drivers of recurrence in numerous cancers. In this study, telomerase enzymatic activity was directly measured and inhibited to assess the therapeutic ...
Tópico(s): Cancer Research and Treatments
2014 - Springer Science+Business Media | Acta Neuropathologica
Stephen C. Mack, Hendrik Witt, Rosario M. Piro, Lei Gu, Scott Zuyderduyn, Adrian M. Stütz, Xin Wang, Marco Gallo, Livia Garzia, Kory Zayne, Xiaoyang Zhang, Vijay Ramaswamy, Natalie Jäger, David Jones, Martin Sill, Trevor J. Pugh, Marina Ryzhova, Khalida Wani, David Shih, Renee Head, Marc Remke, Swneke D. Bailey, Thomas Zichner, Cláudia C. Faria, Mark Barszczyk, Sebastian Stark, Huriye Seker‐Cin, Sonja Hutter, Pascal D. Johann, Sebastian Bender, Volker Hovestadt, Theophilos Tzaridis, Adrian M. Dubuc, Paul A. Northcott, J.H. Peacock, Kelsey C. Bertrand, Sameer Agnihotri, Florence M.G. Cavalli, Ian D. Clarke, Kathleen Nethery-Brokx, Caretha L. Creasy, Sharad K. Verma, Jan Köster, Xiangji Wu, Yuan Yao, Till Milde, Patrick Sin‐Chan, Jennifer Zuccaro, Lynette Lau, Sérgio L. Pereira, Pedro Castelo‐Branco, Martin Hirst, Marco A. Marra, Stephen S. Roberts, Daniel W. Fults, Luca Massimi, Y. J. Cho, Timothy Van Meter, Wiesława Grajkowska, Bolesław Lach, Andreas E. Kulozik, Andreas von Deimling, Olaf Witt, Stephen W. Scherer, Xing Fan, Karin M. Muraszko, Marcel Kool, Scott L. Pomeroy, Nalin Gupta, Joanna J. Phillips, Annie Huang, Uri Tabori, Cynthia Hawkins, David Malkin, Paul Kongkham, William A. Weiss, Nada Jabado, James T. Rutka, Éric Bouffet, Jan O. Korbel, Mathieu Lupien, Kenneth Aldape, Gary D. Bader, Roland Eils, Peter Lichter, Peter B. Dirks, Stefan M. Pfister, Andrey Korshunov, Michael D. Taylor,
Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome sequencing of 47 hindbrain ependymomas reveals an extremely low mutation rate, and zero significant recurrent somatic single nucleotide variants. Although devoid of recurrent single nucleotide variants ...
Tópico(s): Cancer Genomics and Diagnostics
2014 - Nature Portfolio | Nature
Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, Elke Pfaff, David Shih, Dianna C. Martin, Pedro Castelo‐Branco, Berivan Baskin, Peter N. Ray, Éric Bouffet, André O. von Bueren, David Jones, Paul A. Northcott, Marcel Kool, Dominik Sturm, Trevor J. Pugh, Scott L. Pomeroy, Yoon-Jae Cho, Torsten Pietsch, Marco Gessi, Stefan Rutkowski, László Bognár, Álmos Klekner, Byung-Kyu Cho, Seung-Ki Kim, Kyu‐Chang Wang, Charles G. Eberhart, Michelle Fèvre‐Montange, Maryam Fouladi, Pim J. French, Max Kros, Wiesława Grajkowska, Nalin Gupta, William A. Weiss, Péter Hauser, Nada Jabado, Anne Jouvet, Shin Jung, Toshihiro Kumabe, Bolesław Lach, Jeffrey R. Leonard, Joshua B. Rubin, Linda M. Liau, Luca Massimi, Ian F. Pollack, Young Seob Shin, Erwin G. Van Meir, Karel Zitterbart, Ulrich Schüller, Rebecca M. Hill, Janet C. Lindsey, Ed C. Schwalbe, Simon Bailey, David W. Ellison, Cynthia Hawkins, David Malkin, Steven C. Clifford, Andrey Korshunov, Stefan M. Pfister, Michael D. Taylor, Uri Tabori,
Purpose Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles. Patients and Methods We determined subgroup affiliation, TP53 mutation status, and clinical outcome in a discovery cohort of 397 medulloblastomas. We subsequently validated our results on an independent cohort of 156 medulloblastomas. Results TP53 mutations are enriched in wingless (WNT; 16%) and sonic hedgehog ( ...
Tópico(s): Chromatin Remodeling and Cancer
2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Pedro Castelo‐Branco, Sanaa Choufani, Stephen C. Mack, Denis Gallagher, Cindy Zhang, Tatiana Lipman, Nataliya Zhukova, Erin J. Walker, Dianna C. Martin, Diana M. Merino, Jonathan D. Wasserman, Cynthia Elizabeth, Noa Alon, Libo Zhang, Volker Hovestadt, Marcel Kool, David Jones, Gelareh Zadeh, Sidney Croul, Cynthia Hawkins, Johann Hitzler, Jean Wang, Sylvain Baruchel, Peter B. Dirks, David Malkin, Stefan M. Pfister, Michael D. Taylor, Rosanna Weksberg, Uri Tabori,
Background Identification of robust biomarkers of malignancy and methods to establish disease progression is a major goal in paediatric neuro-oncology. We investigated whether methylation of the TERT promoter can be a biomarker for malignancy and patient outcome in paediatric brain tumours. Methods For the discovery cohort, we used samples obtained from patients with paediatric brain tumours and individuals with normal brain tissues stored at the German Cancer Research Center (Heidelberg, Germany). ...
Tópico(s): Hedgehog Signaling Pathway Studies
2013 - Elsevier BV | The Lancet Oncology
Sofía Ravara, Miguel Castelo‐Branco, Pedro Aguiar, José Manuel Calheiros,
Research evaluating enforcement and compliance with smoking partial bans is rather scarce, especially in countries with relative weak tobacco control policies, such as Portugal. There is also scarce evidence on specific high risk groups such as vehicle workers. In January 2008, Portugal implemented a partial ban, followed by poor enforcement. The purpose of this study was to explore the effectiveness of a partial smoking ban in a pro-smoking environment, specifically transportation by taxi in the ...
Tópico(s): School Health and Nursing Education
2013 - BioMed Central | BMC Public Health