Inês Crespo, Artur Paiva, A Couceiro, Pedro Pimentel, Alberto Órfão, Fernando Regateiro,
Dendritic cells (DCs) play a pivotal role in the activation of T cells, which are effector cells in graft-versus-host disease (GVHD). A low incidence of GVHD following cord blood (CB) transplantation has long been reported; despite this, little information is currently available on the characteristics of CB DCs. The goal of the present study was to investigate the immunophenotypic characteristics and distribution of CB DCs and their subsets. For that purpose we have analyzed 15 CB samples as compared ...
Tópico(s): T-cell and B-cell Immunology
2004 - Mary Ann Liebert, Inc. | Stem Cells and Development
Pedro Couceiro, Sara Gómez‐de Pedro, J. Alonso,
Tópico(s): Ferroelectric and Piezoelectric Materials
2014 - Springer Science+Business Media | Microfluidics and Nanofluidics
Miguel Berenguel‐Alonso, Inmaculada Ortiz‐Gómez, Belén Fernández, Pedro Couceiro, J. Alonso, L.F. Capitán‐Vallvey, Alfonso Salinas‐Castillo, Mar Puyol,
This work describes the development of a fully integrated Low Temperature Co-fired Ceramic (LTCC) microreactor for the synthesis of carbon dots (CDots). The microreactor integrates fluidics, a heating resistor and an optical window for fluorescence imaging of the reaction progress in a monolithic, all ceramic device, ensuring homogeneous surface chemistry and physical properties. A pool of different CDots was synthesized at high temperature and pressure using a hydrothermal method, demonstrating the ...
Tópico(s): Quantum Dots Synthesis And Properties
2019 - Elsevier BV | Sensors and Actuators B Chemical
José Gama, Gonçalo Dias, Micael S. Couceiro, Pedro Passos, Keith Davids, João Ribeiro,
Despite clear findings, research on home advantage in team sports lacks a comprehensive theoretical rationale for understanding why this phenomenon is so compelling. The aim of this study was to provide an explanatory theoretical rationale in ecological dynamics for the influence of home advantage observed in research on professional football. We recorded 30 competitive matches and analyzed 13958 passes, from one highly successful team in the Portuguese Premier League, during season 2010/2011. Performance ...
Tópico(s): Sport Psychology and Performance
2016 - World Scientific | International Journal of Modern Physics C
Gonçalo Dias, Micael S. Couceiro, Pedro Cabral Mendes, Maria de Lurdes Almeida,
Ageing is a biosocial process which results in the loss of capacity over time. This decline is gradual and can significantly vary from individual to individual, according to their genetic, morphological and functional characteristics. This chapter shows that regular physical activity can reduce the risk of prevalence of chronic diseases in agieng and reduce the risk of morbidity and mortality of the elderly. For example, physically active elderly can have higher levels of functionality, improved ...
Tópico(s): Health and Wellbeing Research
2017 - Springer Nature (Netherlands) | SpringerBriefs in well-being and quality of life research
Daniel Carrilho, Micael S. Couceiro, João Brito, Pedro Figueiredo, Rui J. Lopes, Duarte Araújo,
The ecological dynamics approach to interpersonal relationships provides theoretical support to the use of kinematic data, obtained with sensor-based systems, in which players of a team are linked mainly by information from the performance environment. Our goal was to capture the properties of synergic behavior in football, using spatiotemporal data from one match of the 2018 FIFA WORLD CUP RUSSIA, to explore the application of player-ball-goal angles in cluster phase analysis. Linear mixed effects ...
Tópico(s): Ecosystem dynamics and resilience
2020 - Multidisciplinary Digital Publishing Institute | Sensors
Ricardo Couceiro, P. Carvalho, Rui Pedro Paiva, J. Henriques, I. Quintal, M. Antunes, Jens Muehlsteff, Christian Eickholt, C. Brinkmeyer, Malte Kelm, Christian Meyer,
Monitoring of cardiovascular function on a beat-to-beat basis is fundamental for protecting patients in different settings including emergency medicine and interventional cardiology, but still faces technical challenges and several limitations. In the present study, we propose a new method for the extraction of cardiovascular performance surrogates from analysis of the photoplethysmographic (PPG) signal alone.
Tópico(s): Heart Rate Variability and Autonomic Control
2015 - IOP Publishing | Physiological Measurement
Ricardo Couceiro, P. Carvalho, Rui Pedro Paiva, J. Henriques, Jens Muehlsteff,
The presence of motion artifacts in photoplethysmographic (PPG) signals is one of the major obstacles in the extraction of reliable cardiovascular parameters in continuous monitoring applications. In the current paper we present an algorithm for motion artifact detection based on the analysis of the variations in the time and the period domain characteristics of the PPG signal. The extracted features are ranked using a normalized mutual information feature selection algorithm and the best features ...
Tópico(s): Hemodynamic Monitoring and Therapy
2014 - IOP Publishing | Physiological Measurement
Ricardo Couceiro, P. Carvalho, Rui Pedro Paiva, Jens Muehlsteff, J. Henriques, Christian Eickholt, C. Brinkmeyer, Malte Kelm, Christian Meyer,
Neurally mediated syncope (NMS) patients suffer from sudden loss of consciousness, which is associated with a high rate of falls and hospitalization. NMS negatively impacts a subject's quality of life and is a growing cost issue in our aging society, as its incidence increases with age. In this paper, we present a solution for prediction of NMS, which is based on the analysis of the electrocardiogram (ECG) and photoplethysmogram (PPG) alone. Several parameters extracted from ECG and PPG, associated ...
Tópico(s): EEG and Brain-Computer Interfaces
2015 - Institute of Electrical and Electronics Engineers | IEEE Journal of Biomedical and Health Informatics
In this work, the influence of laser ablation and lamination parameters in the fabrication of embedded microstructures using Low Temperature Co-Fired Ceramics, have been studied. First, the influence of laser ablation parameters in the dimensions of fabricated microchannels in Low Temperature Co-Fired Ceramics substrates was characterized and strategies for tailoring the microchannels aspect ratios are described. The influence of lamination conditions on the fabrication of monolithically embedded ...
Tópico(s): Electronic and Structural Properties of Oxides
2017 - American Chemical Society | Analytical Chemistry
Sara Gómez‐de Pedro, Miguel Berenguel‐Alonso, Pedro Couceiro, J. Alonso, Mar Puyol,
A simple and automatic microfluidic system to perform a multistep colorimetric magnetic bead-based enzyme-linked oligonucleotide sandwich assay in a short analysis time is reported. As a proof of concept of the advantages of miniaturizing and automating bio-chemical assays, the determination of an Escherichia coli oligonucleotide has been addressed. Moreover, the use of magnetic beads allows simplification of the required cleaning steps as well as the application of an active mixing strategy, based ...
Tópico(s): Biosensors and Analytical Detection
2017 - Elsevier BV | Sensors and Actuators B Chemical
Joana Couceiro, Irina Matos, José João Mendes, Pedro V. Baptista, Alexandra R. Fernandes, Alexandre Quintas,
Preterm birth is a major clinical and public health challenge, with a prevalence of 11% worldwide. It is the leading cause of death in children younger than 5 years old and represents 70% of neonatal deaths and 75% of neonatal morbidity. Despite the clinical and public health significance, this condition's etiology is still unclear, and most of the cases are spontaneous. There are several known preterm birth risk factors, including inflammatory diseases and the genetic background, although the underlying ...
Tópico(s): Pregnancy and Medication Impact
2021 - Wiley | Clinical Genetics
Jan Kloka, Benjamin Friedrichson, Stephanie Dauth, Ann Christina Foldenauer, Anita Bulczak-Schadendorf, Maria J. G. T. Vehreschild, Francisco Maio Matos, Antoni Riera‐Mestre, Thea van Asselt, Edoardo De Robertis, Vilma Traškaitė – Juškevičienė, Patrick Meybohm, Dana Tomescu, Karine Lacombe, Coen D.A. Stehouwer, Kai Zacharowski, Oliver Old, Markus Ketomaeki, Lea Grebe, Patrick Booms, Simone Lindau, Sebastian Zinn, Isabel Maushagen, Timo Wolf, Christoph Stephan, Cathy Weynants, Sylvia Daamen, P. Wülfroth, Thomas Steiner, Marinus van Hulst, Peter Kranke, Sebastian Hottenrott, Tobias Schlesinger, Benedikt Schmid, Daniel Röder, Eva Kranke, T. Haas, Philipp Schlesinger, Magdalena Sitter, Davide Valeri, Raquel Torres Iglesias, José María Mora‐Luján, Adriana Iriarte, Pau Cerdà, Neringa Vagulienė, Andrius Macas, Jolanta Litviniene, Kristina Balne, Catarina Monteiro, Inês Antunes Ferreira, Patrícia Couceiro, Pedro San Martin Soares, Sofia Beirão, Yasmine Abi Aad, Thibault Chiarabini, Mihai Popescu, Carla Kallen,
More than 2.7 million hospitalizations of COVID-19-infected patients have occurred in Europe alone since the outbreak of the coronavirus in 2020. Interventions against SARS-CoV-2 are still in high need to prevent admissions to ICUs worldwide. FX06, a naturally occurring peptide in humans and other mammals, has the potential to reduce capillary leak by improving endothelial dysfunction and thus preventing the deterioration of patients. With IXION, we want to investigate the potential of FX06 to prevent ...
Tópico(s): Thermal Regulation in Medicine
2022 - Springer Science+Business Media | Trials
Erwin Bumm, Haus Appel, Pedro Couceiro,
Tópico(s): Microbial Metabolic Engineering and Bioproduction
1933 - De Gruyter | Hoppe-Seyler´s Zeitschrift für physiologische Chemie
Miguel C. Teixeira, Romeu Viana, Margarida Palma, J. S. Oliveira, Mónica Galocha, Marta N. Mota, Diogo Couceiro, Maria Galhardas Pereira, Miguel Antunes, Inês Vieira Costa, Pedro Pais, Carolina Parada, Claudine Chaouiya, Isabel Sá‐Correia, Pedro T. Monteiro,
Abstract YEASTRACT+ (http://yeastract-plus.org/) is a tool for the analysis, prediction and modelling of transcription regulatory data at the gene and genomic levels in yeasts. It incorporates three integrated databases: YEASTRACT (http://yeastract-plus.org/yeastract/), PathoYeastract (http://yeastract-plus.org/pathoyeastract/) and NCYeastract (http://yeastract-plus.org/ncyeastract/), focused on Saccharomyces cerevisiae, pathogenic yeasts of the Candida genus, and non-conventional yeasts of biotechnological ...
Tópico(s): Biofuel production and bioconversion
2022 - Oxford University Press | Nucleic Acids Research
Grégoire Preud’homme, Kévin Duarte, Kévin Dalleau, Claire Lacomblez, Emmanuel Bresso, Malika Smaïl‐Tabbone, Miguel Couceiro, Marie‐Dominique Devignes, Masatake Kobayashi, Olivier Huttin, João Pedro Ferreira, Faı̈ez Zannad, Patrick Rossignol, Nicolas Girerd,
Abstract The choice of the most appropriate unsupervised machine-learning method for “heterogeneous” or “mixed” data, i.e. with both continuous and categorical variables, can be challenging. Our aim was to examine the performance of various clustering strategies for mixed data using both simulated and real-life data. We conducted a benchmark analysis of “ready-to-use” tools in R comparing 4 model-based (Kamila algorithm, Latent Class Analysis, Latent Class Model [LCM] and Clustering by Mixture Modeling) ...
Tópico(s): Advanced Clustering Algorithms Research
2021 - Nature Portfolio | Scientific Reports
U. Garcia-Couceiro, David Olea, Óscar Castillo, Antonio Luque, P. Román, Pedro Pablo, Julio Gómez‐Herrero, Félix Zamora,
The compound [Mn(μ-ox)(4atr)2]n (1) (ox = oxalato and 4atr = 4-amine-1,2,4-triazole) has been synthesized and characterized by FT-IR spectroscopy, thermal analysis, variable-temperature magnetic measurements, and X-ray single-crystal diffraction methods. The crystal structure of compound 1 consists of one-dimensional linear chains in which trans-[Mn(4atr)2]2+ units are sequentially bridged by centrosymmetric bis-bidentate oxalato ligands. Cryomagnetic measurements show an overall antiferromagnetic behavior ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2005 - American Chemical Society | Inorganic Chemistry
F. Couceiro, Pedro Gamboa, J.M. Silva, Anna Guerman,
This paper addresses the preliminary design of a parabolic structure suitable for specific space applications, such as in solar power collector systems, which relies upon the sole use of an initially flat circular membrane rigidly constrained across its perimeter. In particular, the possibility for this concept to make use of solar pressure as a means of obtaining the intended parabolic curvature is explored. Assuming the membrane´s film as an ideally reflecting surface, parametric studies are conducted ...
Tópico(s): Structural Analysis and Optimization
2013 - Trans Tech Publications | Applied Mechanics and Materials
A monolithic microfluidic free-flow electrophoresis device, fabricated using low-temperature co-fired ceramic technology, is presented. The device integrates gold electrodes and a 20 µm thick transparent ceramic optical window, suitable for fluorescence imaging, into a multilevel microfluidic chamber design. The microfluidic chamber consists of a 60 µm deep separation chamber and two, 50 µm deep electrode chambers separated by 10 µm deep side channel arrays. Fluorescence imaging was used for in- ...
Tópico(s): Biosensors and Analytical Detection
2022 - Multidisciplinary Digital Publishing Institute | Micromachines
Produção Nacional
Revisado por pares
Lucas Sant’Anna, Sérgio Lívio Menezes Couceiro, Eduardo Amar Ferreira, Mariana Bonacossa Sant’Anna, Pedro Rey Cardoso, Evandro Tinoco Mesquita, Guilherme Sant’Anna, Fernando Mendes Sant’Anna,
Objectives: The aim of this study was to evaluate the effects of invasive vagal nerve stimulation (VNS) in patients with chronic heart failure (HF) and reduced ejection fraction (HFrEF). Background: Heart failure is characterized by autonomic nervous system imbalance and electrical events that can lead to sudden death. The effects of parasympathetic (vagal) stimulation in patients with HF are not well-established. Methods: From May 1994 to July 2020, a systematic review was performed using PubMed, Embase, ...
Tópico(s): Heart rate and cardiovascular health
2021 - Frontiers Media | Frontiers in Cardiovascular Medicine
Rui Pedro Paiva, P. Carvalho, Ricardo Couceiro, J. Henriques, M. Antunes, I. Quintal, Jens Muehlsteff,
Systolic time intervals are highly correlated to fundamental cardiac functions. Several studies have shown that these measurements have significant diagnostic and prognostic value in heart failure condition and are adequate for long-term patient follow-up and disease management. In this paper, we investigate the feasibility of using heart sound (HS) to accurately measure the opening and closing moments of the aortic heart valve. These moments are crucial to define the main systolic timings of the ...
Tópico(s): Healthcare Technology and Patient Monitoring
2012 - IOP Publishing | Physiological Measurement
Flávio Reis, Bebiana Sá‐Moura, Diana Guardado, Patrícia Couceiro, Luis Catarino, Anabela Mota‐Pinto, Manuel Teixeira Veríssimo, Ana Teixeira, Pedro Lopes Ferreira, Margarida Pedroso de Lima, Filipe Palavra, Luís Rama, Lèlita Santos, Roel A. van der Heijden, Carlos E. Gonçalves, A. Cunha, João O. Malva,
The prevalence of age-related non-communicable chronic diseases has increased worldwide, being the leading causes of morbidity and death in many world regions, including in Europe. Innovative models and strategies focused on preventive care, including early identification of risk factors underlying disease onset and progression, and proper modification of lifestyle habits and behaviors, might contribute to promote quality of life, healthy living and active ageing. Healthy Lifestyle Innovative Quarters ...
Tópico(s): Physical Activity and Health
2019 - Frontiers Media | Frontiers in Medicine
Gustavo Leso, Gonçalo Dias, José Pedro Ferreira, José Gama, Micael S. Couceiro,
A questionnaire was used to investigate the perception of creativity and game intelligence of coaches (n = 34, mean age 28.6 with an average of 14.3 years of experience) and players (n = 118, belonging to the ranks U-15 and U-19). Analyses indicated that there were statistically significant differences in most creative concepts inherent in the perception of creativity on the part of coaches. The results for the perception of the players showed that there were statistically significant differences in the ...
Tópico(s): Motivation and Self-Concept in Sports
2017 - Taylor & Francis | Creativity Research Journal
Produção Nacional
Tânia Cursino de Menezes Couceiro, Luciana Cavalcanti Lima, Mário Pereira Coutinho Júnior, Pedro Filipe da Luz S. de Oliveira Mello, Thaysi Maria Mendonça Lopes Ferreira, Ana Lígia Pereira Firmino,
BACKGROUND AND OBJECTIVES: To evaluate the prevalence and factors associated with neuropathic pain in cancer patients METHODS: A prospective cross-sectional study conducted from August 2016 to July 2017, with 267 cancer patients above 18 years of age, with pain. Diabetic patients and patients with previous chronic pain unrelated to the current neoplasia were excluded. The demographic and disease information was obtained from the medical records and directly with the patient. The Douleur Neuropathique ...
Tópico(s): Pain Mechanisms and Treatments
2018 - | Brazilian Journal Of Pain
Sara Couceiro, João P. Barreto, Paulo Freire, Pedro Figueiredo,
Confocal Endomicroscopy (CEM) is a newly developed diagnosis tool which provides in vivo examination of the gastrointestinal (GI) histological architecture, avoiding the traditional biopsy . The analysis of CEM images is a challenging task for experts, since there isn’t a clearly defined taxonomy of the several disease stages. We aim at building an automatic on-the-fly classifier to provide useful clinical advices for diagnosis. In this work, we propose to make a split between two main subsets of our ...
Tópico(s): Colorectal Cancer Screening and Detection
2012 - Springer Science+Business Media | Lecture notes in computer science
Maria Couceiro, Pedro Ruivo, Paolo Romano, Luı́s Rodrigues,
Replication plays an essential role for in-memory distributed transactional platforms, given that it represents the primary means to ensure data durability. Unfortunately, no single replication technique can ensure optimal performance across a wide range of workloads and system configurations. This paper tackles this problem by presenting MORPHR, a framework that allows to automatically adapt the replication protocol of in-memory transactional platforms according to the current operational conditions. ...
Tópico(s): Caching and Content Delivery
2014 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Parallel and Distributed Systems
Produção Nacional
Revisado por pares
Francisco Xavier Nobre, Robson Ferrari Muniz, Elmiro Rosendo do Nascimento, Renê Santos de Amorim, R.S. Silva, A. Almeida, J. Agostinho Moreira, Pedro B. Tavares, Walter Ricardo Brito, Paulo Rogério da Costa Couceiro, Y. Leyet,
Tópico(s): Crystal Structures and Properties
2021 - Springer Science+Business Media | Journal of Materials Science Materials in Electronics
Karla Victoria Guevara Amatón, Pedro Couceiro, Hesner Coto Fuentes, Antonio Calvo-López, Natàlia Sández, Héctor Aurelio Moreno Casillas, Francisco Valdés Perezgasga, J. Alonso,
A microanalyzer prototype for copper(II) ion monitoring in mining industrial processes is presented. The microanalyzer is designed as an assembly of different modules, each module being responsible for a unit operation. In order to optimize the industrial processes, the microanalyzer can automate all sample management, signal processing, and mathematical calculations and wirelessly transfer data to a control room. The determination of copper(II) ion is done using a colorimetric reaction and the ...
Tópico(s): Water Quality Monitoring and Analysis
2019 - Multidisciplinary Digital Publishing Institute | Sensors
Pedro Cabral Mendes, Micael S. Couceiro, Rúben Rocha, Filipe Manuel Clemente, Fernando Manuel Lourenço Martins, Rui Mendes, Juan Pedro Fuentes García,
This study analysed the extrinsic constraint of induced aerodynamic flow (IAF) on the first serve by expert tennis players with temporal organization of the movement, as well as the velocity and amplitude of the racket motion analyzed. Twelve expert right-handed tennis players voluntarily participated in this study. Each player performed 20 trials without IAF and another 20 trials for each different speed configuration of induced cross-wind: 2.4 m/s; 4.3 m/s; 5.8 m/s; and random speed. The coefficient ...
Tópico(s): Sports Analytics and Performance
2015 - SAGE Publishing | International Journal of Sports Science & Coaching
Joana Couceiro, Ana Rita Grosso, Pedro V. Baptista, José João Mendes, Alexandra R. Fernandes, Alexandre Quintas,
... preterm birth and periodontal disease – a reviewAll authorsJoana Couceiro, Ana Rita Grosso, Pedro V. Baptista, José J. Mendes, Alexandra R. Fernandes & ...
Tópico(s): Infant Nutrition and Health
2021 - Informa | Annals of Medicine