Ernest Newman, Charlotte M. Reid, Sydenham, A. E. Hyland, M., Edgar Granville, H. M. Abrahams, Peter Rennell Rodd, Captain J. De V. Loder, Mabel Ellams Hope, Yarborough, J. A., Ralph Straus, W. A. B., J. R. Burdon, Ernest Munton, Celia Congreve, L. Robinson, P. S., C. R. A., E. V. Lucas, Laurie Magnus, James Agate, Frank Rutter, F. G. Maughan, Dubliner, Marjorie Pollard, Sydney W. Carroll, George C. Stead, D. R. Gent, Desmond MacCarthy, Atticus, H. C. Minchin, G. T. K. Maurice, O. U. B. C., C. R. C. Nixon, Leon Bertrand, L. Van Vliet, Hesketh Bell, H. Askew, Marjorie Bowen, C. E. Barnett, Dilys Powell, Violet Attwood, J. M. B., Richard Church, H. V. Peirs, H. F., M. P. Lib, Pandora, Hamilton Price, J. M. Sulloch, D. P., Constance Smedley, Violet Hunt, A. C. Jones, Henry Murray, L. C. A. Moxon, R. J. Barrett Financial Editor, Harold Cox,
... Art A New Australian Sculptress The Miracle of Peille Buddenbrooks Multiple Display Advertising Items Ernest Benn Limited ... Muriel Harris. (Cape. 7s. 6d.) "The Miracle of Peille." By J. C. Campbell. (Collina. 6s.) "Laughing Boy." ...
1930 - Gale Group | Sunday Times HA GDA
C. Turino, Davide Scafidi, Elena Eva, Stefano Solarino,
... Together with the Breil–Sospel–Monaco and the Peille–Laghet faults, this line is responsible for the ... Nice arc, could be instead shifted where the Peille–Laghet fault lays.
Tópico(s): Seismic Waves and Analysis
2009 - Elsevier BV | Tectonophysics
C. M. Cookin, Ernest Newman, W. G. Carwardine Probert, Hubert Winterbotham, H. J. Massingham, R. Scott Frew, J. T. Johnson, Yarborough, J. A., E. T. D., Pee Jay, Ralph Straus, James Strong, A. J. Thorogood, John F. Smillie, Hedley Gander, E. B. Jarvis Chief Secretary, J. M. Bulloch, Joyce Evelegh, Stuart Sankey, E. V. Lucas, Laurie Magnus, D. A. V., James Agate, Frank Rutter, Cecil Wall, Alex Davidson, Anglo-Dane, Major-General Sir Fabian Ware, Milton Waldman, Sydney W. Carroll, Gethin W. Griffith, George C. Stead, D. R. Gent, D. B., Desmond MacCarthy, Philip Morrell, Atticus, E. M. K., H. C. Minchin, J. H. Heron, Leon Bertrand, L. Van Vliet, Mr. Campbell Swinton, Marcel Reichel (Special Correspondent of "L'Ami du People, " Paris), R. G. Webb, Wickham Steed, W. H. Woods, J. M. B., (Miss) Christina Roberts, Hanold Cox, H. F., Pandora, Phil. W. Thompson, Hon. John Darling D. S. O., William Farr, Major E. W. Polson Newman, Nina Condron, H. A. Piehler Editor, R. J. Barrett Financial Editor,
... A Government of the Left The Miracle of Peille Chapman & Hall, Ltd. Everyman's Library The Stuffed ...
1930 - Gale Group | Sunday Times HA GDA
Gérard Delanoy, Jean‐Louis Latil,
La carrière du Fontanil à Pont-de-Peille près de Drap (Alpes-Maritimes, France) a révélé l'existence de niveaux albiens jusqu'alors ignorés. L'exploitation de ceux-ci a livré ... found in the Fontanil quarry of Pont-de-Peille, near Drap (Maritim-Alps, France). For the first ...
Tópico(s): Geology and Paleoclimatology Research
1988 - Elsevier BV | Geobios
F. Courboulex, Anne-Marie Duval, A. Deschamps, Anthony Lomax, Christophe Larroque,
The Peille earthquake (Mw=3.4) occurred on 1st November 1999, 15 km to the north of the cities ... depth (3±1.5 km) close to the Peille–Laghet fault trace. Moreover the computed focal mechanism ... of the city of Nice. Le séisme de Peille (Mw=3,4) s'est produit le 1er ... km), près du tracé de la faille de Peille–Laghet. De plus, le mécanisme au foyer de ...
Tópico(s): Geological and Geochemical Analysis
2001 - | Comptes Rendus de l Académie des Sciences - Series IIA - Earth and Planetary Science
Bruno Zeitouni, Cordula Tschuch, Jason M. Davis, Anne-Lise Peille, Yana Raeva, Manuel Landesfeind, Sheri Barnes, Julia Schüler,
... Zeitouni, Cordula Tschuch, Jason M. Davis, Anne-Lise Peille, Yana Raeva, Manuel Landesfeind, Sheri Barnes, Julia B. ...
Tópico(s): Ubiquitin and proteasome pathways
2017 - American Association for Cancer Research | Cancer Research
Julia Schueler, Kerstin Klingner, Daniel Bug, Caren Zoeller, Armin Maier, Meng Dong, Kerstin Willecke, Anne-Lise Peille, Eva Steiner, Manuel Landesfeind, John A. Copland, Gabrielle M. Siegers, Axel Haferkamp, Katharina Böehm, Igor Tsaur, Meike Schneider,
... Meng Dong 8 , Kerstin Willecke 8 , Anne-Lise Peille 1 , Eva Steiner 4 , Manuel Landesfeind 1 , John ...
Tópico(s): Epigenetics and DNA Methylation
2018 - Impact Journals LLC | Oncotarget
D. Barret, Vincent Albouys, Jan-Willem den Herder, L. Piro, M. Cappi, J. Huovelin, Richard L. Kelley, J. M. Más-Hesse, S. Paltani, G. Rauw, A. Różáńska, Jiří Svoboda, J. Wilms, Noriko Y. Yamasaki, M. Audard, S. R. Bandler, Marco Barbera, X. Barcons, E. Bozzo, M. T. Ceballos, I. Charles, E. Costantini, Thomas Dauser, A. Decourchelle, L. Duband, Jean-Marc Duval, F. Fiore, F. Gatti, A. Goldwurm, R. den Hartog, B. D. Jackson, P. G. Jonker, C. A. Kilbourne, Seppo A. Korpela, C. Macculi, Mariano Méndez, Kazuhisa Mitsuda, S. Molendi, François Pajot, É. Pointecouteau, F. S. Porter, G. W. Pratt, D. Prêle, Laurent Ravera, Kosuke Sato, Joop Schaye, Keisuke Shinozaki, Konrad Skup, J. Souĉek, Tanguy Thibert, Jacco Vink, Natalie Webb, Laurence Chaoul, Desi Raulin, A. Simionescu, Jose M. Torrejon, F. Acero, G. Branduardi‐Raymont, S. Ettori, A. Finoguenov, N. Grosso, J. S. Kaastra, P. Mazzotta, J. M. Mïller, G. Miniutti, F. Nicastro, S. Sciortino, Hiroya Yamaguchi, Sophie Beaumont, Edoardo Cucchetti, Matteo D’Andrea, Megan E. Eckart, P. Ferrando, Elias Kammoun, Simone Lotti, Jean-Michel Mesnager, L. Natalucci, Philippe Peille, J. de Plaa, Florence Ardellier, A. Argan, E. Bellouard, Jérôme Carron, E. Cavazzuti, M. Fiorini, P. Khosropanah, Sylvain Martin, James Perry, Frédéric Pinsard, Alice Pradines, Manuela Rigano, Peter Roelfsema, Denis Schwander, G. Torrioli, Joel N. Ullom, I. Vera, Eduardo Medinaceli Villegas, Monika Zuchniak, Frank Brachet, Ugo Lo Cicero, W. B. Doriese, Malcom Durkin, V. Fioretti, Hervé Geoffray, Lionel Jacques, Christian Kirsch, S. J. Smith, J. S. Adams, Emilie Gloaguen, Ruud W. M. Hoogeveen, Paul van der Hulst, Mikko Kiviranta, J. van der Kuur, Aurélien Ledot, Bert-Joost van Leeuwen, Dennis van Loon, Bertrand Lyautey, Yann Parot, Kazuhiro Sakai, H. van Weers, Shariefa Abdoelkariem, Thomas Adam, Christophe Adami, Corinne Aicardi, H. Akamatsu, Pablo Eleazar Merino Alonso, Roberta Amato, Jérôme André, Matteo Angelinelli, Manuel Añon Cancela, Shebli Anvar, Ricardo Atienza, Anthony Attard, N. Auricchio, Ana Balado, Florian Bancel, Lorenzo Ferrari Barusso, Arturo Bascuñán, Vivian Bernard, Alicia Berrocal, Sylvie Blin, D. Bonino, François Bonnet, Patrick Bonny, Peter Boorman, Charles Boreux, Ayoub Bounab, Martin Boutelier, K. R. Boyce, Daniele Brienza, Marcel Bruijn, A. Bulgarelli, Simona Calarco, P. J. Callanan, Alberto Prada Campello, Thierry Camus, Florent Canourgues, V. Capobianco, Nicolas Cardiel, Florent Castellani, Oscar Cheatom, James Chervenak, F. Chiarello, Laurent Clerc, N. Clerc, Beatriz Cobo, O. Coeur-Joly, Alexis Coleiro, S. Colonges, L. Corcione, Mickael Coriat, Alexandre Coynel, F. Cuttaia, A. D’Aì, Fabio D’Anca, Mauro Dadina, Christophe Daniel, Lea Dauner, Natalie DeNigris, Johannes Dercksen, Michael DiPirro, E. Doumayrou, Luc Dubbeldam, M. Dupieux, Simon Dupourqué, Jean Louis Durand, D. Eckert, Valvanera Eiriz, E. Ercolani, Christophe Etcheverry, F. M. Finkbeiner, M. Fiocchi, Hervé Fossecave, Philippe Franssen, Martin Frericks, Stefano Gabici, Florent Gant, J. R. Gao, F. Gastaldello, Ludovic Genolet, S. Ghizzardi, Ma Angeles Alcacera Gil, Elisa Giovannini, O. Godet, Javier Gómez‐Elvira, Raoul Gonzalez, Manuel González, L. Gottardi, Dolorès Granat, M. Gros, Nicolas Guignard, Paul Hieltjes, Adolfo Jesús Hurtado, K. D. Irwin, Christian Jacquey, Agnieszka Janiuk, Jean Jaubert, María S. Jiménez, A. Jolly, Thierry Jourdan, Sabine Julien, B. Kędziora, Andrew Korb, I. Kreykenbohm, Ole König, M. Langer, Philippe Laudet, Philippe Laurent, Monica Laurenza, J. Lesrel, S. Ligori, Maximilian Lorenz, A. Luminari, B. Maffei, Océane Maisonnave, Lorenzo Marelli, Didier Massonet, Irwin Maussang, Alejandro Gonzalo Melchor, Isabelle Le Mer, Francisco Javier San Millan, Jean‐Pierre Millerioux, T. Mineo, G. Minervini, Alexeï Molin, David Monestes, Nicola Montinaro, Baptiste Mot, David Murat, K. Nagayoshi, Yaël Nazé, Loïc Noguès, Damien Pailot, F. Panessa, Luigi Parodi, P. Petit, E. Piconcelli, C. Pinto, Jose Miguel Encinas Plaza, Borja Plaza, David Poyatos Martínez, Thomas Prouvé, A. Ptak, Simonetta Puccetti, Elena Puccio, Pascale Ramon, Manuel Reina, Guillaume Rioland, Louis Rodriguez, Anton Roig, Bertrand Rollet, M. Roncarelli, Gilles Roudil, T. Rudnicki, Julien Sanisidro, Luisa Sciortino, V. Silva, Michaël Sordet, Javier Soto-Aguilar, Pierre Spizzi, C. Surace, Miguel Fernández Sánchez, E. Taralli, Guilhem Terrasa, R. Terrier, Michela Todaro, P. Ubertini, M. Uslenghi, Jan Geralt Bij de Vaate, D. Vaccaro, Salvatore Varisco, P. Varnière, Laurent Vibert, María‐Belén Vidriales, F. Villa, Boris Martin Vodopivec,
The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal ...
Springer Science+Business Media
François Mernier, Edoardo Cucchetti, L. Tornatore, Veronica Biffi, É. Pointecouteau, N. Clerc, Philippe Peille, E. Rasia, D. Barret, S. Borgani, Esra Bülbül, Thomas Dauser, K. Dolag, S. Ettori, M. Gaspari, F. Pajot, M. Roncarelli, J. Wilms,
Chemical enrichment of the Universe at all scales is related to stellar winds and explosive supernovae phenomena. Metals produced by stars and later spread throughout the intracluster medium (ICM) at the megaparsec scale become a fossil record of the chemical enrichment of the Universe and of the dynamical and feedback mechanisms determining their circulation. As demonstrated by the results of the soft X-ray spectrometer onboard Hitomi, high-resolution X-ray spectroscopy is the path to differentiating ...
Tópico(s): Galaxies: Formation, Evolution, Phenomena
2020 - EDP Sciences | Astronomy and Astrophysics
Anne-Lise Peille, Vincent Vuaroqueaux, Swee Seong Wong, Jason C. Ting, Kerstin Klingner, Bruno Zeitouni, Manuel Landesfeind, Woo Ho Kim, Hyuk-Joon Lee, Seong‐Ho Kong, Isabella H. Wulur, Steven M. Bray, Peter Bronsert, Nina Zanella, Gregory P. Donoho, Han‐Kwang Yang, Heinz‐Herbert Fiebig, Christoph Reinhard, Amit Aggarwal,
Abstract Patient-derived xenografts (PDX) have emerged as an important translational research tool for understanding tumor biology and enabling drug efficacy testing. They are established by transfer of patient tumor into immune compromised mice with the intent of using them as Avatars; operating under the assumption that they closely resemble patient tumors. In this study, we established 27 PDX from 100 resected gastric cancers and studied their fidelity in histological and molecular subtypes. We ...
Tópico(s): Cancer Research and Treatments
2020 - Nature Portfolio | Communications Biology
Thomas Dauser, Sebastian Falkner, M. Lorenz, Christian Kirsch, Philippe Peille, Edoardo Cucchetti, Christian Schmid, Thorsten Brand, Mirjam Oertel, Randall K. Smith, J. Wilms,
We give an overview of the SImulation of X-ray TElescopes (SIXTE) software package, a generic, mission-independent Monte Carlo simulation toolkit for X-ray astronomical instrumentation. The package is based on a modular approach for the source definition, the description of the optics, and the detector type such that new missions can be easily implemented. The targets to be simulated are stored in a flexible input format called SIMPUT. Based on this source definition, a sample of photons is produced ...
Tópico(s): Calibration and Measurement Techniques
2019 - EDP Sciences | Astronomy and Astrophysics
Julia Schueler, Cordula Tschuch, Kerstin Klingner, Daniel Bug, Anne-Lise Peille, Leanne de Koning, Eva Oswald, Hagen Klett, Wolfgang Sommergruber,
In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor receptor (EGFR). Although these patients gain great benefit from treatment with EGFR tyrosine kinase inhibitors, the development of resistance is inevitable. To model the emergence of drug resistance, an EGFR-driven, patient-derived xenograft (PDX) NSCLC model was treated continuously with Gefitinib in vivo. Over a period of more than three months, ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2019 - Multidisciplinary Digital Publishing Institute | Cells
Edoardo Cucchetti, N. Clerc, É. Pointecouteau, Philippe Peille, F. Pajot,
X-ray observations of the hot gas filling the intra-cluster medium provide a wealth of information on the dynamics of clusters of galaxies. The global equilibrium of the ICM is believed to be partially ensured by non-thermal pressure support, notably the dissipation of energy through turbulent motions. Accurate mapping of turbulence using X-ray emission lines is challenging due to the lack of spatially-resolved spectroscopy. Only future instruments such as the X-ray Integral Field Unit (X-IFU) on ...
Tópico(s): Galaxies: Formation, Evolution, Phenomena
2019 - EDP Sciences | Astronomy and Astrophysics
Philippe Peille, Thomas Dauser, Christian Kirsch, R. den Hartog, Edoardo Cucchetti, J. Wilms, D. Barret, J. W. den Herder, L. Piro,
Tópico(s): Particle Detector Development and Performance
2018 - Springer Science+Business Media | Journal of Low Temperature Physics
Edoardo Cucchetti, É. Pointecouteau, Philippe Peille, N. Clerc, E. Rasia, Veronica Biffi, S. Borgani, L. Tornatore, Klaus Dolag, M. Roncarelli, M. Gaspari, S. Ettori, Esra Bülbül, Thomas Dauser, J. Wilms, F. Pajot, D. Barret,
Answers to the metal production of the Universe can be found in galaxy clusters, notably within their intra-cluster medium (ICM). The X-ray Integral Field Unit (X-IFU) on board the next-generation European X-ray observatory Athena (2030s) will provide the necessary leap forward in spatially-resolved spectroscopy required to disentangle the intricate mechanisms responsible for this chemical enrichment. In this paper, we investigate the future capabilities of the X-IFU in probing the hot gas within galaxy ...
Tópico(s): Gamma-ray bursts and supernovae
2018 - EDP Sciences | Astronomy and Astrophysics
F. Pajot, D. Barret, T. Lam-Trong, J. W. den Herder, L. Piro, M. Cappi, J. Huovelin, Richard L. Kelley, J. M. Más-Hesse, Kazuhisa Mitsuda, S. Paltani, G. Rauw, A. Różáńska, J. Wilms, Marco Barbera, F. Douchin, Hervé Geoffray, R. den Hartog, C. A. Kilbourne, Michel Le Du, C. Macculi, Jean-Michel Mesnager, Philippe Peille,
The X-ray Integral Field Unit (X-IFU) of the Advanced Telescope for High-ENergy Astrophysics (Athena) large-scale mission of ESA will provide spatially resolved high-resolution X-ray spectroscopy from 0.2 to 12 keV, with 5 $$^{\prime \prime }$$ pixels over a field of view of 5 arc minute equivalent diameter and a spectral resolution of 2.5 eV (FWHM) up to 7 keV. The core scientific objectives of Athena drive the main performance parameters of the X-IFU. We present the current reference configuration of the X- ...
Tópico(s): X-ray Spectroscopy and Fluorescence Analysis
2018 - Springer Science+Business Media | Journal of Low Temperature Physics
S.M. Gilbert, CJ Oliphant, Sakinah Hassan, AL Peille, Peter Bronsert, Simonetta Falzoni, Francesco Di Virgilio, Shaun McNulty, Romain Lara,
The ATP-gated receptor P2X7 is expressed in multiple malignant tumours including neuroblastoma, melanoma, prostate, lung and breast. P2X7 has a significant role in mediating diverse cell responses, which upon dysregulation are associated with tumour initiation and development. The rapid, ATP-mediated activation of P2X7 induces a fast-inward cation current in cells. However, prolonged ATP-mediated activation of P2X7 leads to formation of a pore that increases membrane permeability and eventually ...
Tópico(s): Neuroscience of respiration and sleep
2018 - Springer Nature | Oncogene
S. J. Smith, J. S. Adams, S. R. Bandler, Gabriele L. Betancourt-Martinez, J. A. Chervenak, Meng P. Chiao, Megan E. Eckart, F. M. Finkbeiner, Richard L. Kelley, C. A. Kilbourne, Antoine R. Miniussi, F. S. Porter, J. E. Sadleir, Kazuhiro Sakai, Nicholas A. Wakeham, E. J. Wassell, Wonisk Yoon, D. A. Bennett, W. B. Doriese, Joseph W. Fowler, G. C. Hilton, Kelsey M. Morgan, Christine G. Pappas, Carl Reintsema, Daniel S. Swetz, Joel N. Ullom, K. D. Irwin, Hiroki Akamatsu, L. Gottardi, R. den Hartog, B. D. Jackson, J. van der Kuur, D. Barret, Philippe Peille,
The focal plane of the X-ray integral field unit (X-IFU) for ESA's Athena X-ray observatory will consist of ~ 4000 transition edge sensor (TES) x-ray microcalorimeters optimized for the energy range of 0.2 to 12 keV. The instrument will provide unprecedented spectral resolution of ~ 2.5 eV at energies of up to 7 keV and will accommodate photon fluxes of 1 mCrab (90 cps) for point source observations. The baseline configuration is a uniform large pixel array (LPA) of 4.28" pixels that is read out using frequency ...
Tópico(s): Physics of Superconductivity and Magnetism
2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
D. Barret, Thien Lam Trong, Jan-Willem den Herder, L. Piro, X. Barcons, J. Huovelin, Richard L. Kelley, J. M. Más-Hesse, Kazuhisa Mitsuda, Stéphane Paltani, G. Rauw, A. Różáńska, J. Wilms, Marco Barbera, E. Bozzo, M. T. Ceballos, I. Charles, A. Decourchelle, R. den Hartog, Jean-Marc Duval, F. Fiore, F. Gatti, Andrea Goldwurm, B. D. Jackson, P. G. Jonker, C. A. Kilbourne, C. Macculi, Mariano Méndez, S. Molendi, P. Orleański, François Pajot, É. Pointecouteau, F. S. Porter, G. W. Pratt, D. Prêle, Laurent Ravera, Étienne Renotte, Joop Schaye, Keisuke Shinozaki, L. Valenziano, Jacco Vink, Natalie Webb, Noriko Y. Yamasaki, Françoise Delcelier-Douchin, Michel Le Du, Jean-Michel Mesnager, Alice Pradines, G. Branduardi‐Raymont, M. Dadina, A. Finoguenov, Y. Fukazawa, Agnieszka Janiuk, J. M. Mïller, Yaël Nazé, F. Nicastro, S. Sciortino, Jose M. Torrejon, Hervé Geoffray, Isabelle Hernandez, Laure Luno, Philippe Peille, Jérôme André, Christophe Daniel, Christophe Etcheverry, Emilie Gloaguen, Jérémie Hassin, Gilles Hervet, Irwin Maussang, Jérôme Moueza, Alexis Paillet, Bruno Vella, Gonzalo Campos Garrido, Jean-Charles Damery, Chantal Panem, J. Panh, S. R. Bandler, Jean-Marc Biffi, K. R. Boyce, Antoine Clénet, Michael DiPirro, Pierre Jamotton, Simone Lotti, Denis Schwander, S. J. Smith, Bert-Joost van Leeuwen, H. van Weers, Thorsten Brand, Beatriz Cobo, Thomas Dauser, J. de Plaa, Edoardo Cucchetti,
The X-ray Integral Field Unit (X-IFU) on board the Advanced Telescope for High-ENergy Astrophysics (Athena) will provide spatially resolved high-resolution X-ray spectroscopy from 0.2 to 12 keV, with 5 arc second pixels over a field of view of 5 arc minute equivalent diameter and a spectral resolution of 2.5 eV up to 7 keV. In this paper, we first review the core scientific objectives of Athena, driving the main performance parameters of the X-IFU, namely the spectral resolution, the field of view, ...
Tópico(s): Advanced X-ray Imaging Techniques
2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Philippe Peille, M. T. Ceballos, Beatriz Cobo, J. Wilms, S. R. Bandler, S. J. Smith, Thomas Dauser, Thorsten Brand, R. den Hartog, J. de Plaa, D. Barret, Jan-Willem den Herder, L. Piro, X. Barcons, É. Pointecouteau,
The X-ray Integral Field Unit (X-IFU) microcalorimeter, on-board Athena, with its focal plane comprising 3840 Transition Edge Sensors (TESs) operating at 90 mK, will provide unprecedented spectral-imaging capability in the 0.2-12 keV energy range. It will rely on the on-board digital processing of current pulses induced by the heat deposited in the TES absorber, as to recover the energy of each individual events. Assessing the capabilities of the pulse reconstruction is required to understand the ...
Tópico(s): Calibration and Measurement Techniques
2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
J. Wilms, S. J. Smith, Philippe Peille, M. T. Ceballos, Beatriz Cobo, Thomas Dauser, Thorsten Brand, Roland H. den Hartog, S. R. Bandler, J. de Plaa, Jan-Willem den Herder,
We present the design of tessim, a simulator for the physics of transition edge sensors developed in the framework of the Athena end to end simulation effort. Designed to represent the general behavior of transition edge sensors and to provide input for engineering and science studies for Athena, tessim implements a numerical solution of the linearized equations describing these devices. The simulation includes a model for the relevant noise sources and several implementations of possible trigger ...
Tópico(s): Particle Detector Development and Performance
2016 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Armin Maier, Anne-Lise Peille, Vincent Vuaroqueaux, Michael Lahn,
The transforming growth factor-beta (TGF-β) signaling pathway is known to play a critical role in promoting tumor growth. Consequently, blocking this pathway has been found to inhibit tumor growth. In order to achieve an optimal anti-tumor effect, however, it remains to be established whether blocking the TGF-β signaling pathway alone is sufficient, or whether the tumor microenvironment plays an additional, possibly synergistic, role.To investigate the relevance of blocking TGF-β signaling in tumor ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2015 - Springer Nature | Cellular Oncology
Philippe Peille, D. Barret, P. Uttley,
Soft lags from the emission of the lower kilohertz quasi-periodic oscillations (kHz QPOs) of neutron star low mass X-ray binaries have been reported from 4U1608-522 and 4U1636-536. Those lags hold prospects for constraining the origin of the QPO emission. In this paper, we investigate the spectral-timing properties of both the lower and upper kHz QPOs from the neutron star binary 4U1728-34, using the entire Rossi X-ray Timing Explorer archive on this source. We show that the lag-energy spectra of ...
Tópico(s): High-pressure geophysics and materials
2015 - IOP Publishing | The Astrophysical Journal
Laurent Ravera, D. Barret, J. W. den Herder, L. Piro, R. Clédassou, É. Pointecouteau, Philippe Peille, François Pajot, M. Arnaud, C. Pigot, L. Duband, C. Cara, Roland H. den Hartog, L. Gottardi, H. Akamatsu, J. van der Kuur, Henk J. van Weers, J. de Plaa, C. Macculi, Simone Lotti, G. Torrioli, F. Gatti, L. Valenziano, Marco Barbera, X. Barcons, M. T. Ceballos, L. Fábrega, J. M. Más-Hesse, Mathew Page, Phillip R. Guttridge, R. Willingale, S. Paltani, Ludovic Genolet, E. Bozzo, G. Rauw, Étienne Renotte, J. Wilms, Christian Schmid,
Athena is designed to implement the Hot and Energetic Universe science theme selected by the European Space Agency for the second large mission of its Cosmic Vision program. The Athena science payload consists of a large aperture high angular resolution X-ray optics (2 m2 at 1 keV) and twelve meters away, two interchangeable focal plane instruments: the X-ray Integral Field Unit (X-IFU) and the Wide Field Imager. The X-IFU is a cryogenic X-ray spectrometer, based on a large array of Transition Edge ...
Tópico(s): Astrophysical Phenomena and Observations
2014 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
J. Wilms, Thorsten Brand, D. Barret, Tobias Beuchert, Jan-Willem den Herder, I. Kreykenbohm, Simone Lotti, Norbert Meidinger, K. Nandra, Philippe Peille, L. Piro, A. Rau, Christian Schmid, Randall K. Smith, C. Tenzer, Michael Wille, R. Willingale,
We present an overview of the development of the end-to-end simulation programs for the instruments on the future European X-ray astronomy mission Athena. The overview includes the design considerations behind the simulation software and the current status and planned developments of the simulators for the X-ray Integral Field Unit and the Wide Field Imager.
Tópico(s): Advanced X-ray Imaging Techniques
2014 - SPIE | Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
Sophie Javerzat, Mélanie Franco, John Herbert, Natalia Platonova, Anne-Lise Peille, Véronique Pantesco, John De Vos, Saïd Assou, Roy Bicknell, Andréas Bikfalvi, Martin Hagedorn,
Background Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. Determining genes, which drive vascular maturation is crucial for the identification of new therapeutic targets against pathological angiogenesis. Methology/Principal Findings We accessed global gene regulation throughout maturation of the chick chorio-allantoic membrane (CAM), a highly vascularized tissue, using pan genomic microarrays. Seven percent ...
Tópico(s): Kruppel-like factors research
2009 - Public Library of Science | PLoS ONE
Ralf‐Joachim Kohal, Wael Att, Maria Bächle, Frank Butz,
... Christel P, Meunier A, Heller M, Torre JP, Peille CN. Mechanical properties and short-term in-vivo ...
Tópico(s): Orthodontics and Dentofacial Orthopedics
2008 - Wiley | Periodontology 2000
F. Courboulex, Christian Larroque, A. Deschamps, C. Kohrs-Sansorny, Céline Gélis, Jean‐Luc Got, Julien Charreau, J. F. Stéphan, N. Béthoux, J. Virieux, Didier Brunel, Christophe Maron, Anne-Marie Duval, J.L Díaz Pérez, P. Mondielli,
... Blausasc fault is the hidden root of the Peille-Laghet fault, which has a mapped length of ...
Tópico(s): Geological and Geochemical Analysis
2007 - Oxford University Press | Geophysical Journal International
P. Christel, Alain Meunier, Markus O. Heller, J. P. Torre, C. N. Peille,
Abstract Yttrium‐oxide‐partially‐stabilized zirconia (YPSZ) belongs to a new class of ceramics exhibiting an improved toughness when compared to alumina. The toughening mechanism is related to a martensitic‐like transformation of tetragonal metastable grains into a monoclinic state occurring at the crack tip. Specific tests showed that YPSZ exhibited a high bending strength (900–1200 MPa), a low Young's modulus (200 GPa), and a high toughness ( K IC = 9–10 MN/m 3/2 ). Its average grain size of 0.5 m̈m allows ...
Tópico(s): Advanced materials and composites
1989 - Wiley | Journal of Biomedical Materials Research
Anne-Lise Peille, Véronique Brouste, Audrey Kauffmann, Pauline Lagarde, Valérie Le Morvan, Jean‐Michel Coindre, Frédéric Chibon, Laurence Bresson‐Bepoldin,
Soft tissue sarcomas (STS) are rare, complex tumors with a poor prognosis. The identification of new prognostic biomarkers is needed to improve patient management. Our aim was to determine the methylation status of the 118 CpG sites in the PLAGL1 tumor-suppressor gene P1 CpG island promoter and study the potential prognostic impact of PLAGL1 promoter methylation CpG sites in STS. Training cohorts constituted of 28 undifferentiated sarcomas (US) and 35 leiomyosarcomas (LMS) were studied. PLAGL1 mRNA ...
Tópico(s): Tumors and Oncological Cases
2013 - Public Library of Science | PLoS ONE