Book.
0000 - Gale Group | The Making of Modern World
Claudio Sette, Maria Paola Paronetto, Marco Barchi, Arturo Bevilacqua, Raffaele Geremia, Pellegrino Rossi,
... Italy Search for more papers by this author Pellegrino Rossi Pellegrino Rossi Department of Public Health and Cell Biology, Section ... Italy Search for more papers by this author Pellegrino Rossi Pellegrino Rossi Department of Public Health and Cell Biology, Section of Anatomy, University of Rome ‘Tor Vergata’, Via Montpellier 1, Italy Search for more papers by this author Author Information Claudio Sette 1, Maria Paola Paronetto1, Marco Barchi1, Arturo Bevilacqua2, Raffaele Geremia1 and Pellegrino Rossi1 1Department of Public Health and Cell Biology, ...
Tópico(s): Reproductive System and Pregnancy
2002 - Springer Nature | The EMBO Journal
... Bastiat. - Michel Chevalier. - John Stuart Mill. - Léon Faucher. - Pellegrino Rossi Book.
0000 - Gale Group | MOMW2
Benoît De Crombrugghe, Gérard Karsenty, Sankar N. Maity, Tuula Vuorio, Pellegrino Rossi, E. Cristy Ruteshouser, Sandra McKinney, Guillermina Lozano,
... 77030Search for more papers by this authorPELLEGRINO ROSSI, PELLEGRINO ROSSI Department of Molecular Genetics The University of Texas ... 77030Search for more papers by this authorPELLEGRINO ROSSI, PELLEGRINO ROSSI Department of Molecular Genetics The University of Texas ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
1990 - Wiley | Annals of the New York Academy of Sciences
Book.
0000 - Gale Group | The Making of Modern World
Valeriana Cesarini, Maurizio Martini, Lucia Ricci‐Vitiani, Giovanni Luca Gravina, Silvia Di Agostino, Grazia Graziani, Quintino Giorgio D’Alessandris, Roberto Pallini, Luigi Maria Larocca, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci,
... 7 , Roberto Pallini 7 , Luigi M. Larocca 2 , Pellegrino Rossi 1 , Emmanuele A. Jannini 6 , Susanna Dolci 1 ...
Tópico(s): Histone Deacetylase Inhibitors Research
2017 - Impact Journals LLC | Oncotarget
Rossi, Pellegrino, Trinchera, Francesco, Rau, Karl Heinrich, Blanch, Luigi,
Translation of the 2nd edition of: Cours d'économie politique. Translated by Giuseppe Roncagli. Book.
0000 - Gale Group | The Making of Modern World
Eugenia Guida, Valentina Tassinari, Ambra Colopi, Federica Todaro, Valeriana Cesarini, Benedetto Jannini, Manuela Pellegrini, Flavia Botti, Gabriele Rossi, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci,
ABSTRACT Germ cell tumors (GCTs) are rare tumors that can develop in both sexes, peaking in adolescents. To understand the mechanisms that underlie germ cell transformation, we established a GCT mouse model carrying a germ-cell-specific BRafV600E mutation with or without heterozygous Pten deletion. Both male and female mice developed monolateral teratocarcinomas containing embryonal carcinoma (EC) cells that showed an aggressive phenotype and metastatic ability. Germ cell transformation started in ...
Tópico(s): Hedgehog Signaling Pathway Studies
2022 - The Company of Biologists | Journal of Cell Science
Book.
0000 - Gale Group | The Making of Modern World
Emanuela De Domenico, Federica Todaro, Gabriele Rossi, Susanna Dolci, Raffaele Geremia, Pellegrino Rossi, Paola Grimaldi,
Type 2 cannabinoid receptor (CB2R) has been proposed to promote in vitro meiotic entry of postnatal male germ cells and to maintain the temporal progression of spermatogenesis in vivo. However, no information is presently available on the role played by CB2R in male and female fetal gonads. Here we show that in vitro pharmacological stimulation with JWH133, a CB2R agonist, induced activation of the meiotic program in both male and female fetal gonads. Upon stimulation, gonocytes initiated the meiotic ...
Tópico(s): Epigenetics and DNA Methylation
2017 - Springer Nature | Cell Death and Disease
Rossi, Pellegrino, Trinchera, Francesco, Rau, Karl Heinrich, Blanch, Luigi,
Translation: Cours d'économie politique. 2 columns per page. Book.
0000 - Gale Group | The Making of Modern World
Raffaele De, Rafael Boscolo‐Berto, Marco Artico, Eugenio Bertelli, M. Cannas, Francesco Cappello, Guido Carpino, Sergio Castorina, Amelia Cataldi, Guido Cavaletti, Saverio Cinti, Lucio Cocco, Ottavio Cremona, Enrico Crivellato, Antonio De Luca, Mirella Falconi, Giuseppe Familiari, Gian‐Luca Ferri, Francesco Fornai, Marco Gesi, Stefano Geuna, Daniele Gibelli, Antonio Giordano, Pietro Gobbi, Germano Guerra, Massimo Gulisano, Veronica Macchi, Guido Macchiarelli, Lucia Manzoli, Fabrizio Michetti, Sebastianó Miscia, Stefania Montagnani, Andrea Montella, S. Morini, Paolo Onori, Carla Palumbo, Michèle Papa, Andrea Porzionato, Daniela Elena Quacci, Mario Raspanti, Mario Rende, Rita Rezzani, Doménico Ribatti, M. Ripani, Luigi Fabrizio Rodella, Pellegrino Rossi, Andrea Sbarbati, Paola Secchiero, Chiarella Sforza, Carla Stecco, Roberto Toni, Alessandro Vercelli, Marco Vitale, Carlo Zancanaro, Giorgio Zauli, Sandra Zecchi, Giuseppe Anastasi, Eugenio Gaudio,
In Italy, recent legislation (Law No. 10/2020) has tuned regulations concerning the donation of one's postmortem body and tissues for study, training, and scientific research purposes. This study discusses several specific issues to optimise the applicability and effectiveness of such an important, novel regulatory setting. Critical issues arise concerning the learners, the type of training and teaching activities that can be planned, the position of academic anatomy institutes, the role of family ...
Tópico(s): Organ and Tissue Transplantation Research
2021 - Elsevier BV | Annals of Anatomy - Anatomischer Anzeiger
Rossi, Pellegrino, Trinchera, Francesco, Rau, Karl Heinrich, Blanch, Luigi,
Translation of the 2nd edition of: Cours d'économie politique. Translated by Giuseppe Roncagli. Book.
0000 - Gale Group | The Making of Modern World
Cinzia Caggiano, Francesca Cavallo, Teresa Giannattasio, Gioia Cappelletti, Pellegrino Rossi, Paola Grimaldi, Darren R. Feldman, Maria Jasin, Marco Barchi,
Despite germ cell tumors (GCTs) responding to cisplatin-based chemotherapy at a high rate, a subset of patients does not respond to treatment and have significantly worse prognosis. The biological mechanisms underlying the resistance remain unknown. In this study, by using two TGCT cell lines that have acquired cisplatin resistance after chronic exposure to the drug, we identified some key proteins and mechanisms of acquired resistance. We show that cisplatin-resistant cell lines had a non-homologous ...
Tópico(s): Testicular diseases and treatments
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Book.
0000 - Gale Group | The Making of Modern World
Marco Barchi, Elisa Innocenzi, Teresa Giannattasio, Susanna Dolci, Pellegrino Rossi, Paola Grimaldi,
Endocannabinoids are natural lipid molecules whose levels are regulated by specific biosynthetic and degradative enzymes. They bind to and activate two main cannabinoid receptors type 1 (CB1) and type 2 (CB2), and together with their metabolizing enzymes form the "endocannabinoid system" (ECS). In the last years, the relevance of endocannabinoids (eCBs) as critical modulators in various aspects of male reproduction has been pointed out. Mammalian male germ cells, from mitotic to haploid stage, have a ...
Tópico(s): Sperm and Testicular Function
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Book.
0000 - Gale Group | The Making of Modern World
Valeriana Cesarini, Eugenia Guida, Federica Todaro, Silvia Di Agostino, Valentina Tassinari, Silvia K. Nicolis, Rebecca Favaro, Simona Caporali, Pedro Miguel Lacal, E. Botti, Antonio Costanzo, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci,
Melanoma is a dangerous form of skin cancer derived from the malignant transformation of melanocytes. The transcription factor SOX2 is not expressed in melanocytes, however, it has been shown to be differentially expressed between benign nevi and malignant melanomas and to be essential for melanoma stem cell maintenance and expansion in vitro and in xenograft models. By using a mouse model in which BRafV600E mutation cooperates with Pten loss to induce the development of metastatic melanoma, we ...
Tópico(s): Genomics and Chromatin Dynamics
2017 - Springer Nature | Oncogene
Book.
0000 - Gale Group | The Making of Modern World
Sara Di Siena, Roberto Gimmelli, Stefania Lucia Nori, Federica Barbagallo, Federica Campolo, Susanna Dolci, Pellegrino Rossi, Mary Anna Venneri, Elisa Giannetta, Daniele Gianfrilli, Lionel Feigenbaum, Andrea Lenzi, Fabio Naro, Eleonora Cianflone, Teresa Mancuso, Daniele Torella, Andrea M. Isidori, Manuela Pellegrini,
Abstract The role of endogenous c-Kit receptor activation on cardiac cell homeostasis and repair remains largely unexplored. Transgenic mice carrying an activating point mutation (TgD814Y) in the kinase domain of the c-Kit gene were generated. c-Kit TgD814Y receptor was expressed in the heart during embryonic development and postnatal life, in a similar timing and expression pattern to that of the endogenous gene, but not in the hematopoietic compartment allowing the study of a cardiac-specific phenotype. ...
Tópico(s): Tissue Engineering and Regenerative Medicine
2016 - Springer Nature | Cell Death and Disease
Book.
0000 - Gale Group | The Making of Modern World
Monica Faieta, Stefano Di Cecca, Dirk G. de Rooij, Andrea Luchetti, Michela Murdocca, Monica Di Giacomo, Sara Di Siena, Manuela Pellegrini, Pellegrino Rossi, Marco Barchi,
Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes. Haploidization is achieved via two successive rounds of chromosome segregation, meiosis I and II. In mammals, during prophase of meiosis I, homologous chromosomes align and synapse through a recombination-mediated mechanism initiated by the introduction of DNA double-strand breaks (DSBs) by the SPO11 protein. In male mice, if SPO11 expression ...
Tópico(s): Microtubule and mitosis dynamics
2015 - Springer Science+Business Media | Chromosoma
Valentina Tassinari, Federica Campolo, Valeriana Cesarini, Federica Todaro, Susanna Dolci, Pellegrino Rossi,
Abstract Both fibroblast growth factor 9 (Fgf9) and Kit Ligand (Kl) signal through tyrosine kinase receptors, yet they exert opposite effects on meiotic differentiation in postnatal spermatogonia, Fgf9 acting as a meiosis-inhibiting substance and Kl acting as a promoter of the differentiation process. To understand the molecular mechanisms that might underlie this difference, we tried to dissect the intracellular signaling elicited by these two growth factors. We found that both Fgf9 and Kl stimulate ...
Tópico(s): Fibroblast Growth Factor Research
2015 - Springer Nature | Cell Death and Disease
Federica Campolo, Manuele Gori, Rebecca Favaro, Silvia K. Nicolis, Manuela Pellegrini, Flavia Botti, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci,
Abstract Sox2 is a pluripotency-conferring gene expressed in primordial germ cells (PGCs) and postnatal oocytes, but the role it plays during germ cell development and early embryogenesis is unknown. Since Sox2 ablation causes early embryonic lethality shortly after blastocyst implantation, we generated mice bearing Sox2-conditional deletion in germ cells at different stages of their development through the Cre/loxP recombination system. Embryos lacking Sox2 in PGCs show a dramatic decrease of germ ...
Tópico(s): Renal and related cancers
2013 - Oxford University Press | Stem Cells
Pellegrino Rossi, Susanna Dolci,
Within the testis, Sertoli cell is the primary target of pituitary FSH. Several growth factors have been described to be produced specifically by Sertoli cells and modulate male germ cell development through paracrine mechanisms. Some have been shown to act directly on spermatogonia such as GDNF, which acts on self-renewal of spermatogonial stem cells (SSCs) while inhibiting their differentiation; BMP4, which has both a proliferative and differentiative effect on these cells, and KL, which stimulates ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2013 - Frontiers Media | Frontiers in Endocrinology
The characterization of the mechanisms that regulate KIT expression in germ cells at different times of their development is important not only in the field of reproduction, but also for a better understanding of the biology of testicular germ cell tumors (TGCTs). Indeed this tyrosine kinase receptor, besides being essential for the survival and proliferation of primordial germ cells (PGCs) and for postnatal spermatogenesis and oogenesis, is also frequently overexpressed or constitutively active due ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2013 - University of the Basque Country | The International Journal of Developmental Biology
Florencia Barrios, Doria Filipponi, Federica Campolo, Manuele Gori, Federica Bramucci, Manuela Pellegrini, Sergio Ottolenghi, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci,
How Kit expression is regulated in the germline remains unknown.SOHLH1 and SOHLH2, two bHLH transcription factors specifically expressed in germ cells, are involved in spermatogonia and oocyte differentiation.In the male, deletion of each factor causes loss of Kitexpressing spermatogonia in the prepuberal testis.In the female, SOHLH1 and SOHLH2 ablations cause oocyte loss in the neonatal ovary.To investigate whether Kit expression is regulated by these two factors in male germ cells, we examined ...
Tópico(s): Animal Genetics and Reproduction
2012 - The Company of Biologists | Development
Florencia Barrios, Doria Filipponi, Federica Campolo, Manuele Gori, Federica Bramucci, Manuela Pellegrini, Sergio Ottolenghi, Pellegrino Rossi, Emmanuele A. Jannini, Susanna Dolci,
How Kit expression is regulated in the germline is still an open question. SOHLH1 and SOHLH2, two bHLH transcription factors specifically expressed in germ cells, have been recently involved in the differentiation of spermatogonia and oocytes. In the male, deletion of each transcription factor leads to the disappearance of Kit-expressing spermatogonia in the prepuberal testis. In the female, both SOHLH1 and SOHLH2 ablations are responsible of oocyte loss in the neonatal ovary. To investigate if ...
Tópico(s): Epigenetics and DNA Methylation
2012 - The Company of Biologists | Journal of Cell Science
Valeria Messina, Annarita Di Sauro, Simona Pedrotti, Laura Adesso, A Latina, Raffaele Geremia, Pellegrino Rossi, Claudio Sette,
Translation of stored mRNAs accounts for protein synthesis during the transcriptionally inactive stages of spermatogenesis. A key step in mRNA translation is the assembly of the initiation complex EIF4F, which is regulated by the MTOR (mammalian target of rapamycin) and MNK1/2 (MAP kinase-interacting kinase 1 and 2) pathways. We investigated the expression and activity of regulatory proteins of these pathways in male germ cells at different stages of differentiation. All translation factors analyzed ...
Tópico(s): Pluripotent Stem Cells Research
2010 - Oxford University Press | Biology of Reproduction
Manuela Pellegrini, Giuseppina Claps, Valeria V. Orlova, Florencia Barrios, Susanna Dolci, Raffaele Geremia, Pellegrino Rossi, Gabriele Rossi, Bernd Arnold, Triantafyllos Chavakis, Lionel Feigenbaum, Shyam K. Sharan, André Nussenzweig,
Meiosis is a crucial process for the production of functional gametes. However, the biological significance of many genes expressed during the meiotic phase remains poorly understood, mainly because of the lethal phenotypes of the knockout mice. Functional analysis of such genes using the conditional knockout approach is hindered by the lack of suitable Cre transgenic lines. We describe here the generation of transgenic mice expressing Cre recombinase under the control of the meiotic Spo11 gene. ...
Tópico(s): Sperm and Testicular Function
2010 - The Company of Biologists | Journal of Cell Science