Pritesh Jain, Tyne W. Miller‐Fleming, Apostolia Topaloudi, Dongmei Yu, Petros Drineas, Marianthi Georgitsi, Zhiyu Yang, Renata Rizzo, Kirsten Müller‐Vahl, Zeynep Tümer, Nanette Mol Debes, Andreas Hartmann, Christel Depienne, Yulia Worbe, Pablo Mir, Daniëlle C. Cath, Dorret I. Boomsma, Veit Roessner, Tomasz Wolañczyk, Piotr Janik, Natalia Szejko, Cezary Żekanowski, Csaba Barta, Zsófia Nemoda, Zsanett Tárnok, Joseph D. Buxbaum, Dorothy E. Grice, Jeffrey Glennon, Hreinn Stefánsson, Bastian Hengerer, Noa Benaroya-Milshtein, Francesco Cardona, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Àstrid Morer, Norbert Mueller, Alexander Münchau, Kerstin Jessica Plessen, Cesare Porcelli, Susanne Walitza, Anette Schrag, Davide Martino, Thomas D. Als, H.N. Aschauer, Gil Atzmon, Matie Bækvad-Hansen, Csaba Barta, Cathy L. Barr, Nir Barzilai, James R. Batterson, Robert Batterson, Fortu Benarroch, Cheston M. Berlin, Julia Boberg, Benjamin Bodmer, Julia Bohnenpoll, Anders D. Børglum, Lawrence W. Brown, Ruth D. Bruun, Cathy L. Budman, Randy L. Buckner, Joseph D. Buxbaum, Jonas Bybjerg‐Grauholm, Daniëlle C. Cath, Keun‐Ah Cheon, Sylvain Chouinard, Barbara Coffey, Giovanni Coppola, James J. Crowley, Niklas Dahl, Lea K. Davis, Sabrina M. Darrow, Mark J. Daly, Christel Depienne, Silvia De Rubeis, Andrea Dietrich, Yves Dion, Diana R. Djurfeldt, Laura Domenech-Salgado, Valsamma Eapen, Lonneke Elzerman, Thomas Fernandez, Nelson B. Freimer Carolin Fremer, Blanca García-Delgar, Marcos Madruga Garrido, Donald L. Gilbert, Paola Giusti‐Rodríguez, Marco A. Grados, Erica Greenberg, Jakob Grove, Dorothy E. Grice, Julie Hagstrøm, Matthew Halvorsen, Andreas Hartmann, Bjarne Hansen, Jan Haavik, Johannes Hebebrand, Gary A. Heiman, Luis Diego Herrera, Isobel Heyman, Anke Hinney, Matthew E. Hirschtritt, Pieter J. Hoekstra, Jae Hoon Sul, Hyun Ju Hong, David M. Hougaard, Alden Y. Huang, Laura Ibanez-Gomez, Franjo Ivankovic, Joseph Jankovic, Elinor K. Karlsson, Jakko A. Kaprio, Young Key Kim, Young‐Shin Kim, Robert A. King, James A. Knowles, Yun‐Joo Koh, Sodham Kook, Najah Khalifa, Anastasios Konstantinidis, Samuel Kuperman, Roger Kurlan, Gerd Kvale, James F. Leckman, Paul C. Lee, Bennett Leventhal, Paul Lichtenstein, Kerstin Lindbald-Toh, Thomas L. Lowe, Andrea G. Ludolph, Claudia Luhrs da Silva, Pétur Lúðvígsson, Jurjen J. Luykx, Gholson J. Lyon, Behrang Mahjani, Athanasios Maras, David Mataix‐Cols, Manuel Mattheisen, Carol A. Mathews, Irene A. Malaty, William M. McMahon, Andrew McQuillin, Sandra Meier, Tyne W. Miller‐Fleming, Pablo Mir, Rainald Moessner, Àstrid Morer, Preben Bo Mortensen, Ole Mors, Poorva Mudgal, Kirsten Müller‐Vahl, Alexander Münchau, Péter Nagy, Allan L. Naarden, Benjamin M. Neale, Muhammad Sulaman Nawaz, Judith Becker Nissen, Markus M. Nöthen Merete Nordentoft, Ashley E. Nordsletten, Michael S. Okun, Roel A. Ophoff, Lisa Osiecki, Aarno Palotie, Teemu Palviainen, Peristera Paschou, Carlos N. Pato, Christopher Pittenger, Kerstin Jessica Plessen, Yehuda Pollak, Daniëlle Posthuma, Eliana Marisa Ramos, Jennifer Reichert, Renata Rizzo, Mary M. Robertson, Veit Roessner, Joshua L. Roffman, Guy A. Rouleau, Christian Rück, Evald Sæmundsen, Jack Samuels, Sven Sandin, Paul Sandor, Monika Schlögelhofer, Jeremiah M. Scharf, Eun‐Young Shin, Harvey S. Singer, Jan Smit, Jordan W. Smoller, Matthew W. State, Stian Solem, Dong‐Ho Song, Jungeun Song, M. Stamenković, Hreinn Stefánsson, Hreinn Stefánsson, Nora I. Strom, Manfred Stuhrmann, Jin Szatkiewicz, Urszula Szymańska, Zsanett Tárnok, Jay A. Tischfield, Fotis Tsetsos, Ólafur Thorarensen, Jennifer Tübing, Frank Visscher, Michael Wagner, Sina Wanderer, Sheng Wang, Thomas Werge, Jeremy A. Willsey, Tomasz Wolancyk, Douglas W. Woods, Martin Woods, Yulia Worbe, Yves Dion, Dongmei Yu, Ivette Zelaya, Samuel H. Zinner, Alan Apter, Juliane Ball, Benjamin Bodmer, Emese Bognár, Judith Buse, Marta Correa Vela, Carolin Fremer, Blanca García-Delgar, Mariangela Gulisano, Annelieke Hagen, Julie Hagstrøm, Marcos Madruga-Garrido, Péter Nagy, Alessandra Pellico, Daphna Ruhrman, Jaana Schnell, Paola Rosaria Silvestri, Liselotte Skov, Tamar Steinberg, Friederike Tagwerker Gloor, Victoria Turner, Elif Weidinger, Noa Benaroya-Milshtein, Francesco Cardona, Andrea Dietrich, Marianthi Georgitsi, Tammy Hedderly, Isobel Heyman, Pieter J. Hoekstra, Chaim Huyser, Davide Martino, Pablo Mir, Àstrid Morer, Kirsten Müller‐Vahl, Peristera Paschou, Kerstin Jessica Plessen, Cesare Porcelli, Renata Rizzo, Veit Roessner, Anette Schrag, Zsanett Tárnok, Andrea Dietrich, John J. Alexander, Tamàs Arànyi, Wim Buisman, Jan K. Buitelaar, Nicole N. Driessen, Petros Drineas, Siyan Fan, Natalie J. Forde, Sarah Gerasch, Odile A. van den Heuvel, Cathrine Jespersgaard, Ahmad S. Kanaan, Harald E. Möller, Muhammad Sulaman Nawaz, Ester Nespoli, Luca Pagliaroli, Geert Poelmans, Petra J. W. Pouwels, Francesca Romana Rizzo, Dick J. Veltman, Ysbrand D. van der Werf, Joanna Widomska, Nuno R. Zilhão, Csaba Barta, Dorret I. Boomsma, Daniëlle C. Cath, Marianthi Georgitsi, Jeffrey Glennon, Bastian Hengerer, Pieter J. Hoekstra, Kirsten Müller‐Vahl, Peristera Paschou, Hreinn Stefánsson, Zeynep Tümer, Carol A. Mathews,
Abstract Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. Epidemiological studies have shown TS to be correlated with other phenotypes, but large-scale phenome wide analyses in biobank level data have not been performed to date. In this study, we used the summary statistics from the latest meta-analysis of TS to calculate the polygenic ...
Springer Nature
Fotis Tsetsos, Dongmei Yu, Jae Hoon Sul, Alden Y. Huang, Cornelia Illmann, Lisa Osiecki, Sabrina M. Darrow, Matthew E. Hirschtritt, Erica Greenberg, Kirsten Müller‐Vahl, Manfred Stuhrmann, Yves Dion, Guy A. Rouleau, H.N. Aschauer, M. Stamenković, Monika Schlögelhofer, Paul Sandor, Cathy L. Barr, Marco A. Grados, Harvey S. Singer, Markus M. Nöthen, Johannes Hebebrand, Anke Hinney, Robert A. King, Thomas Fernandez, Csaba Barta, Zsanett Tárnok, Péter Nagy, Christel Depienne, Yulia Worbe, Andreas Hartmann, Cathy L. Budman, Renata Rizzo, Gholson J. Lyon, William M. McMahon, James R. Batterson, Daniëlle C. Cath, Irene A. Malaty, Michael S. Okun, Cheston M. Berlin, Douglas W. Woods, Paul C. Lee, Joseph Jankovic, Mary M. Robertson, Donald L. Gilbert, Lawrence W. Brown, Barbara J. Coffey, Andrea Dietrich, Pieter J. Hoekstra, Samuel Kuperman, Samuel H. Zinner, Michael Wagner, James A. Knowles, A. Jeremy Willsey, Jay A. Tischfield, Gary A. Heiman, Nancy J. Cox, Nelson B. Freimer, Benjamin M. Neale, Lea K. Davis, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Peristera Paschou, Cathy L. Barr, James R. Batterson, Cheston M. Berlin, Cathy L. Budman, Daniëlle C. Cath, Giovanni Coppola, Nancy J. Cox, Sabrina M. Darrow, Lea K. Davis, Yves Dion, Nelson B. Freimer, Marco A. Grados, Erica Greenberg, Matthew E. Hirschtritt, Alden Y. Huang, Cornelia Illmann, Robert A. King, Roger Kurlan, James F. Leckman, Gholson J. Lyon, Irene A. Malaty, Carol A. Mathews, William M. McMahon, Benjamin M. Neale, Michael S. Okun, Lisa Osiecki, Mary M. Robertson, Guy A. Rouleau, Paul Sandor, Jeremiah M. Scharf, Harvey S. Singer, Jan Smit, Jae Hoon Sul, Dongmei Yu, Harald Aschauer Harald Aschauer, Csaba Barta, Cathy L. Budman, Daniëlle C. Cath, Christel Depienne, Andreas Hartmann, Johannes Hebebrand, Anastasios Konstantinidis, Carol A. Mathews, Kirsten Müller‐Vahl, Péter Nagy, Markus M. Nöthen, Peristera Paschou, Renata Rizzo, Guy A. Rouleau, Paul Sandor, Jeremiah M. Scharf, Monika Schlögelhofer, M. Stamenković, Manfred Stuhrmann, Fotis Tsetsos, Zsanett Tárnok, Tomasz Wolañczyk, Yulia Worbe, Lawrence W. Brown, Keun‐Ah Cheon, Barbara J. Coffey, Andrea Dietrich, Thomas Fernandez, Blanca García-Delgar, Donald L. Gilbert, Dorothy E. Grice, Julie Hagstrøm, Tammy Hedderly, Gary A. Heiman, Isobel Heyman, Pieter J. Hoekstra, Chaim Huyser, Young Key Kim, Young‐Shin Kim, Robert A. King, Yun‐Joo Koh, Sodahm Kook, Samuel Kuperman, Bennett Leventhal, Marcos Madruga‐Garrido, Pablo Mir, Àstrid Morer, Alexander Münchau, Kerstin Jessica Plessen, Veit Roessner, Eun‐Young Shin, Dong‐Ho Song, Jungeun Song, Jay A. Tischfield, A. Jeremy Willsey, Samuel H. Zinner, H.N. Aschauer, Cathy L. Barr, Csaba Barta, James R. Batterson, Cheston M. Berlin, Lawrence W. Brown, Cathy L. Budman, Daniëlle C. Cath, Barbara J. Coffey, Giovanni Coppola, Nancy J. Cox, Sabrina M. Darrow, Lea K. Davis, Christel Depienne, Andrea Dietrich, Yves Dion, Thomas Fernandez, Nelson B. Freimer, Donald L. Gilbert, Marco A. Grados, Erica Greenberg, Andreas Hartmann, Johannes Hebebrand, Gary A. Heiman, Matthew E. Hirschtritt, Pieter J. Hoekstra, Alden Y. Huang, Cornelia Illmann, Joseph Jankovic, Robert A. King, Samuel Kuperman, Paul C. Lee, Gholson J. Lyon, Irene A. Malaty, Carol A. Mathews, William M. McMahon, Kirsten Müller‐Vahl, Péter Nagy, Benjamin M. Neale, Markus M. Nöthen, Michael S. Okun, Lisa Osiecki, Peristera Paschou, Renata Rizzo, Mary M. Robertson, Guy A. Rouleau, Paul Sandor, Jeremiah M. Scharf, Monika Schlögelhofer, Harvey S. Singer, M. Stamenković, Manfred Stuhrmann, Jae Hoon Sul, Zsanett Tárnok, Jay A. Tischfield, Fotis Tsetsos, A. Jeremy Willsey, Douglas W. Woods, Yulia Worbe, Dongmei Yu, Samuel H. Zinner,
Abstract Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. ...
Tópico(s): Autism Spectrum Disorder Research
2021 - Springer Nature | Translational Psychiatry
Sheng Wang, Jeffrey D. Mandell, Yogesh Kumar, Nawei Sun, Montana T. Morris, Juan David Arbelaez, Cara Nasello, Shan Dong, Clif Duhn, Xin Zhao, Zhiyu Yang, Shanmukha Sampath Padmanabhuni, Dongmei Yu, Robert A. King, Andrea Dietrich, Najah Khalifa, Niklas Dahl, Alden Y. Huang, Benjamin M. Neale, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Thomas Fernandez, Joseph D. Buxbaum, Silvia De Rubeis, Dorothy E. Grice, Jinchuan Xing, Gary A. Heiman, Jay A. Tischfield, Peristera Paschou, A. Jeremy Willsey, Matthew W. State, Mohamed Abdulkadir, Juan David Arbelaez, Benjamin Bodmer, Yana Bromberg, Lawrence W. Brown, Keun‐Ah Cheon, Barbara J. Coffey, Li Deng, Andrea Dietrich, Dong Shan, Clif Duhn, Lonneke Elzerman, Thomas V. Fernandez, Carolin Fremer, Blanca García-Delgar, Donald L. Gilbert, Dorothy E. Grice, Julie Hagstrøm, Tammy Hedderly, Gary A. Heiman, Isobel Heyman, Pieter J. Hoekstra, Hyun Ju Hong, Chaim Huyser, Eunjoo Kim, Young Key Kim, Young-Shin Kim, Robert A. King, Yun‐Joo Koh, Sodahm Kook, Samuel Kuperman, Bennett Leventhal, Andrea G. Ludolph, Marcos Madruga-Garrido, Jeffrey D. Mandell, Athanasios Maras, Pablo Mir, Àstrid Morer, Montana T. Morris, Kirsten Müller‐Vahl, Alexander Münchau, Tara Murphy, Cara Nasello, Kerstin Jessica Plessen, Hannah Poisner, Veit Roessner, Stephan Sanders, Eun-Young Shin, Dong‐Ho Song, Jungeun Song, Matthew W. State, Nawei Sun, Joshua K. Thackray, Jay A. Tischfield, Jennifer Tübing, Frank Visscher, Sina Wanderer, Sheng Wang, A. Jeremy Willsey, Martin Woods, Jinchuan Xing, Yeting Zhang, Xin Zhao, Samuel H. Zinner, Christos Androutsos, Csaba Barta, Luca Farkas, Jakub Fichna, Marianthi Georgitsi, Piotr Janik, Iordanis Karagiannidis, Anastasia Koumoula, Peter Nagy, Peristera Paschou, Joanna Puchala, Renata Rizzo, Natalia Szejko, Urszula Szymańska, Zsanett Tárnok, Vaia Tsironi, Tomasz Wolañczyk, Cezary Żekanowski, Cathy L. Barr, James R. Batterson, Cheston M. Berlin, Ruth D. Bruun, Cathy L. Budman, Daniëlle C. Cath, Sylvain Chouinard, Giovanni Coppola, Nancy J. Cox, Sabrina M. Darrow, Lea K. Davis, Yves Dion, Nelson B. Freimer, Marco A. Grados, Matthew E. Hirschtritt, Alden Y. Huang, Cornelia Illmann, Robert A. King, Roger Kurlan, James F. Leckman, Gholson J. Lyon, Irene A. Malaty, Carol A. Mathews, William M. MacMahon, Benjamin M. Neale, Michael S. Okun, Lisa Osiecki, David L. Pauls, Daniëlle Posthuma, Vasily Ramensky, Mary M. Robertson, Guy A. Rouleau, Paul Sandor, Jeremiah M. Scharf, Harvey S. Singer, Jan Smit, Jae-Hoon Sul, Dongmei Yu,
Highlights•Recurrent de novo variants identify a new high-confidence TD risk gene: CELSR3•Genes involved in cell polarity are more likely to be disrupted by de novo variants•De novo sequence variants may carry more risk in simplex families, female probands•De novo CNVs occur 2 to 3 times more often in TD probands than in matched controlsSummaryWe previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, ...
Tópico(s): Plant Reproductive Biology
2018 - Cell Press | Cell Reports
Fotis Tsetsos, Apostolia Topaloudi, Pritesh Jain, Zhiyu Yang, Dongmei Yu, Petros Kolovos, Zeynep Tümer, Renata Rizzo, Andreas Hartmann, Christel Depienne, Yulia Worbe, Kirsten Müller‐Vahl, Daniëlle C. Cath, Dorret I. Boomsma, Tomasz Wolañczyk, Cezary Żekanowski, Csaba Barta, Zsófia Nemoda, Zsanett Tárnok, Shanmukha Sampath Padmanabhuni, Joseph D. Buxbaum, Dorothy E. Grice, Jeffrey Glennon, Hreinn Stefánsson, Bastian Hengerer, Evangelia Yannaki, J Stamatoyannopoulos, Noa Benaroya-Milshtein, Francesco Cardona, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Pablo Mir, Àstrid Morer, Norbert Mueller, Alexander Münchau, Kerstin Jessica Plessen, Cesare Porcelli, Veit Roessner, Susanne Walitza, Anette Schrag, Davide Martino, Cathy L. Barr, James R. Batterson, Cheston M. Berlin, Cathy L. Budman, Giovanni Coppola, Nancy J. Cox, Sabrina M. Darrow, Yves Dion, Nelson B. Freimer, Marco A. Grados, Erica Greenberg, Matthew E. Hirschtritt, Alden Y. Huang, Cornelia Illmann, Robert A. King, Roger Kurlan, James F. Leckman, Gholson J. Lyon, Irene A. Malaty, William M. McMahon, Benjamin M. Neale, Michael S. Okun, Lisa Osiecki, Mary M. Robertson, Guy A. Rouleau, Paul Sandor, Harvey S. Singer, Jan Smit, Jae Hoon Sul, Christos Androutsos, Entela Basha, Luca Farkas, Jakub Fichna, Piotr Janik, M. Kapisyzi, Iordanis Karagiannidis, Anastasia Koumoula, Peter Nagy, Joanna Puchala, Natalia Szejko, Urszula Szymańska, Vaia Tsironi, Alan Apter, Juliane Ball, Benjamin Bodmer, Emese Bognár, Judith Buse, Marta Correa Vela, Carolin Fremer, Blanca Garcia-Delgar, Mariangela Gulisano, Annelieke Hagen, Julie Hagstrøm, Marcos Madruga-Garrido, Peter Nagy, Alessandra Pellico, Daphna Ruhrman, Jaana Schnell, Paola Rosaria Silvestri, Liselotte Skov, Tamar Steinberg, Friederike Tagwerker Gloor, Victoria Turner, Elif Weidinger, John J. Alexander, Tamás Arányi, Wim Buisman, Jan K. Buitelaar, Nicole N. Driessen, Petros Drineas, Siyan Fan, Natalie J. Forde, Sarah Gerasch, Odile A. van den Heuvel, Cathrine Jespersgaard, Ahmad S. Kanaan, Harald E. Möller, Muhammad Sulaman Nawaz, Ester Nespoli, Luca Pagliaroli, Geert Poelmans, Petra J. W. Pouwels, Francesca Romana Rizzo, Dick J. Veltman, Ysbrand D. van der Werf, Joanna Widomska, Nuno R. Zilhão, Lawrence W. Brown, Keun‐Ah Cheon, Barbara Coffey, Thomas V. Fernandez, Blanca Garcia-Delgar, Donald L. Gilbert, Julie Hagstrøm, Hyun Ju Hong, Laura Ibanez-Gomez, Eunjoo Kim, Young Key Kim, Young-Shin Kim, Robert A. King, Yun-Joo Koh, Sodahm Kook, Samuel Kuperman, Bennett Leventhal, Marcos Madruga-Garrido, Athanasios Maras, Tara Murphy, Eun-Young Shin, Dong‐Ho Song, Jungeun Song, Matthew W. State, Frank Visscher, Sheng Wang, Samuel H. Zinner, Jay A. Tischfield, Gary A. Heiman, A. Jeremy Willsey, Andrea Dietrich, Lea K. Davis, James J. Crowley, Carol A. Mathews, Jeremiah M. Scharf, Marianthi Georgitsi, Pieter J. Hoekstra, Peristera Paschou,
Background Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder of complex genetic architecture and is characterized by multiple motor tics and at least one vocal tic persisting for more than 1 year. Methods We performed a genome-wide meta-analysis integrating a novel TS cohort with previously published data, resulting in a sample size of 6133 individuals with TS and 13,565 ancestry-matched control participants. Results We identified a genome-wide significant locus on chromosome ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2023 - Elsevier BV | Biological Psychiatry
Peristera Paschou, Νικόλαος Σιώμος, Alexandra Tsekeri, Alexandros Louridas, George Georgoussis, Volker Freudenthaler, Ioannis Binietoglou, George Tsaknakis, Alexandros Tavernarakis, Christos Evangelatos, Jonas von Bismarck, Thomas Kanitz, Charikleia Meleti, Eleni Marinou, Vassilis Amiridis,
Abstract. The eVe dual-laser/dual-telescope lidar system is introduced here, focusing on the optical and mechanical parts of the system's emission and receiver units. The compact design of the linear–circular emission unit along with the linear–circular analyser in the receiver unit allows eVe to simultaneously reproduce the operation of the ALADIN lidar on board Aeolus as well as to operate it as a traditional ground-based polarisation lidar system with linear emission. As such, the eVe lidar aims ...
Tópico(s): Atmospheric chemistry and aerosols
2022 - Copernicus Publications | Atmospheric measurement techniques
Dimitrios Pliatsios, Panagiotis Sarigiannidis, Θωμάς Λάγκας, Vasileios Argyriou, Alexandros‐Apostolos A. Boulogeorgos, Peristera A. Baziana,
The Internet of Vehicles (IoV) is an emerging paradigm, which is expected to be an integral component of beyond-fifth-generation and sixth-generation mobile networks. However, the processing requirements and strict delay constraints of IoV applications pose a challenge to vehicle processing units. To this end, multi-access edge computing (MEC) can leverage the availability of computing resources at the edge of the network to meet the intensive computation demands. Nevertheless, the optimal allocation ...
Tópico(s): IoT Networks and Protocols
2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Green Communications and Networking
Lisa Pleyer, Michael Leisch, Alexandra Kourakli, Eric Padron, Jaroslaw P. Maciejewski, Blanca Xicoy Cirici, Jennifer Kaivers, Johanna Ungerstedt, Sonja Heibl, Peristera Patiou, Anthony M. Hunter, Elvira Mora, Klaus Geißler, Maria Dimou, María-José Jiménez Lorenzo, Thomas Melchardt, Alexander Egle, Athina-Nora Viniou, Bhumika Jayantibhai Patel, Montserrat Arnán, Peter Valent, Christoforos Roubakis, Teresa Bernal, Athanasios Galanopoulos, Marisa Calabuig, Nicolas Bonadies, António Almeida, Jaroslav Čermák, Andrés Jerez, María Julia Montoro, Albert Cortés‐Bullich, Alejandro Pita, Bernardo López Andrade, Eva Hellstroem-Lindberg, Ulrich Germing, Mikkael A. Sekeres, Alan F. List, Argiris Symeonidis, Guillermo Sanz, Julian Larcher‐Senn, Richard Greil,
Tópico(s): Neutropenia and Cancer Infections
2021 - Elsevier BV | The Lancet Haematology
Athanasios Roumeliotis, Stefanos Roumeliotis, Fotis Tsetsos, Marianthi Georgitsi, Panagiotis I. Georgianos, Aikaterini Stamou, Anna Vasilakou, Kalliopi Kotsa, Xanthippi Tsekmekidou, Peristera Paschou, Stylianos Panagoutsos, Vassilios Liakopoulos,
Diabetic type 2 patients compared to nondiabetic patients exhibit an increased risk of developing diabetic kidney disease (DKD), the leading cause of end-stage renal disease. Hyperglycemia, hypertension, oxidative stress (OS), and genetic background are some of the mechanisms and pathways implicated in DKD pathogenesis. However, data on OS pathway susceptibility genes show limited success and conflicting or inconclusive results. Our study is aimed at exploring OS pathway genes and variants which could ...
Tópico(s): Glutathione Transferases and Polymorphisms
2021 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Amanda M. Levy, Peristera Paschou, Zeynep Tümer,
Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental and -psychiatric tic-disorder of complex etiology which is often comorbid with obsessive-compulsive disorder (OCD) and/or attention deficit hyperactivity disorder (ADHD). Twin and family studies of GTS individuals have shown a high level of heritability suggesting, that genetic risk factors play an important role in disease etiology. However, the identification of major GTS susceptibility genes has been challenging, presumably ...
Tópico(s): Autism Spectrum Disorder Research
2021 - Multidisciplinary Digital Publishing Institute | Genes
Sarah O’Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong, Hayden Schneider, Wei Shi, Stephen High,
ABSTRACT In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2, the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several SARS-CoV-2 components synthesised at the endoplasmic reticulum (ER) of infected human cells prior to the assembly of new viral particles. Hence, the inhibition of membrane ...
Tópico(s): Bacteriophages and microbial interactions
2021 - The Company of Biologists | Journal of Cell Science
Zhiyu Yang, Hanrui Wu, Phil H. Lee, Fotis Tsetsos, Lea K. Davis, Dongmei Yu, Sang Lee, Søren Dalsgaard, Jan Haavik, Csaba Barta, Tetyana Zayats, Valsamma Eapen, Naomi R. Wray, Bernie Devlin, Mark J. Daly, Benjamin M. Neale, Anders D. Børglum, James J. Crowley, Jeremiah M. Scharf, Carol A. Mathews, Stephen V. Faraone, Barbara Franke, Manuel Mattheisen, Jordan W. Smoller, Peristera Paschou,
Tourette syndrome (TS) is often found comorbid with other neurodevelopmental disorders across the impulsivity-compulsivity spectrum, with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) as most prevalent. This points to the possibility of a common etiological thread along an impulsivity-compulsivity continuum.
Tópico(s): Genetic Associations and Epidemiology
2021 - Elsevier BV | Biological Psychiatry
Alexandra Tsekeri, Vassilis Amiridis, Alexandros Louridas, George Georgoussis, Volker Freudenthaler, Spiros Metallinos, George Doxastakis, Josef Gasteiger, Νικόλαος Σιώμος, Peristera Paschou, Thanasis Georgiou, George Tsaknakis, Christos Evangelatos, Ioannis Binietoglou,
Abstract. Dust orientation has been an ongoing investigation in recent years. Its potential proof will be a paradigm shift for dust remote sensing, invalidating the currently used simplifications of randomly oriented particles. Vertically resolved measurements of dust orientation can be acquired with a polarization lidar designed to target the off-diagonal elements of the backscatter matrix which are nonzero only when the particles are oriented. Building on previous studies, we constructed a lidar ...
Tópico(s): Atmospheric chemistry and aerosols
2021 - Copernicus Publications | Atmospheric measurement techniques
Constanze Leineweber, Claudia Bernhard‐Oettel, Constanze Eib, Paraskevi Peristera, Jian Li,
Earlier studies suggest that imbalance between effort and reward at work associates with exhaustion. Others have found that exhaustion increases turnover intentions; an important precursor of actual turnover that also associates with counterproductive work behaviors. Few, however, have studied the associations between effort-reward imbalance (ERI) and employees' intentions to leave their current employment, and whether exhaustion is underpinning that relationship. Here, we investigate the mediating ...
Tópico(s): Healthcare professionals’ stress and burnout
2021 - Wiley | Journal of Occupational Health
Paul M. Thompson, Neda Jahanshad, Christopher R. K. Ching, Lauren E. Salminen, Sophia I. Thomopoulos, Joanna K. Bright, Bernhard T. Baune, Sara Bertolín, Janita Bralten, Willem B. Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G. F. de Kovel, Gary Donohoe, Lisa T. Eyler, Stephen V. Faraone, Pauline Favre, Courtney A. Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J. Grabe, Katrina L. Grasby, Tomáš Hájek, Laura K. M. Han, Sean N. Hatton, Kevin Hilbert, Tiffany C. Ho, Laurena Holleran, Georg Homuth, Norbert Hosten, Josselin Houenou, Iliyan Ivanov, Tianye Jia, Sinéad Kelly, Marieke Klein, Jun Soo Kwon, Max A. Laansma, Jeanne Leerssen, Ulrike Lueken, Abraham Nunes, Joseph O' Neill, Nils Opel, Fabrizio Piras, Federica Piras, Merel C. Postema, Elena Pozzi, Natalia Shatokhina, Carles Soriano‐Mas, Gianfranco Spalletta, Daqiang Sun, Alexander Teumer, Amanda K. Tilot, Leonardo Tozzi, Celia van der Merwe, Eus J.W. Van Someren, Guido van Wingen, Henry Völzke, Esther Walton, Lei Wang, Anderson M. Winkler, Katharina Wittfeld, Margaret J. Wright, Je‐Yeon Yun, Guohao Zhang, Yanli Zhang‐James, Bhim M. Adhikari, Ingrid Agartz, Moji Aghajani, André Alemán, Robert R. Althoff, André Altmann, Ole A. Andreassen, David Baron, Brenda Bartnik‐Olson, Janna Marie Bas‐Hoogendam, Arielle Baskin–Sommers, Carrie E. Bearden, Laura A. Berner, Premika S.W. Boedhoe, Rachel M. Brouwer, Jan K. Buitelaar, Karen Caeyenberghs, Charlotte A. M. Cecil, Ronald A. Cohen, James H. Cole, Patricia Conrod, Stéphane A. De Brito, Sonja M. C. de Zwarte, Emily L. Dennis, Sylvane Desrivières, Danai Dima, Stefan Ehrlich, Carrie Esopenko, Graeme Fairchild, Simon E. Fisher, Jean‐Paul Fouché, Clyde Francks, Sophia Frangou, Barbara Franke, Hugh Garavan, David C. Glahn, Nynke A. Groenewold, Tiril P. Gurholt, Boris A. Gutman, Tim Hahn, Ian H. Harding, Dennis Hernaus, Derrek P. Hibar, Frank G. Hillary, Martine Hoogman, Hilleke E. Hulshoff Pol, Maria Jalbrzikowski, George A Karkashadze, Eduard T. Klapwijk, Rebecca Knickmeyer, Peter Kochunov, Inga K. Koerte, Xiangzhen Kong, Sook‐Lei Liew, Alexander P. Lin, Mark W. Logue, Eileen Lüders, Fabìo Macciardi, Scott Mackey, Andrew R. Mayer, Carrie R. McDonald, Agnes B. McMahon, Sarah E. Medland, Gemma Modinos, Rajendra A. Morey, Sven C. Mueller, Pratik Mukherjee, Leyla S. Namazova-Baranova, Talia M. Nir, Alexander Olsen, Peristera Paschou, Daniel Pine, Fabrizio Pizzagalli, Miguel E. Rentería, Jonathan D. Rohrer, Philipp G. Sämann, Lianne Schmaal, Günter Schumann, Mark S. Shiroishi, Sanjay M. Sisodiya, Dirk J. A. Smit, Ida E. Sønderby, Dan J. Stein, Jason L. Stein, Masoud Tahmasian, David F. Tate, Jessica A. Turner, Odile A. van den Heuvel, Nic J.A. van der Wee, Ysbrand D. van der Werf, Theo G.M. van Erp, Neeltje E.M. van Haren, Daan van Rooij, Laura S. van Velzen, Ilya M. Veer, Dick J. Veltman, Julio E. Villalón‐Reina, Henrik Walter, Christopher D. Whelan, Elisabeth A. Wilde, Mojtaba Zarei, Vladimir Zelman,
Abstract This review summarizes the last decade of work by the ENIGMA ( E nhancing N euro I maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental ...
Tópico(s): Health, Environment, Cognitive Aging
2020 - Springer Nature | Translational Psychiatry
Constanze Leineweber, Paraskevi Peristera, Claudia Bernhard‐Oettel, Constanze Eib,
Research on the relationship between organizational justice and turnover has mainly focused on turnover intentions rather than behavior, and the role of health in this relationship has been widely ignored. In his study, we hypothesized that interpersonal justice perceptions and self-rated health impact on later group (changing work groups while staying in the organization) and organizational turnover (changing organizations). The main effect of self-rated health on group and organizational turnover, ...
Tópico(s): Gender Diversity and Inequality
2020 - Elsevier BV | Social Science & Medicine
Guanghui Zong, Zhijian Hu, Sarah O’Keefe, Dale Tranter, Michael J. Iannotti, Ludivine Baron, Belinda S. Hall, Katherine Corfield, Anja Paatero, Mark J. Henderson, Peristera Roboti, Jianhong Zhou, Xianwei Sun, Mugunthan Govindarajan, Jason M. Rohde, Nicolas Blanchard, Rachel E. Simmonds, James Inglese, Yuchun Du, Caroline Demangel, Stephen High, Ville O. Paavilainen, Wei Shi,
Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with single-digit nanomolar potency. However, its biological and pharmacological properties have remained largely unexplored. Building upon our earlier achievements in total synthesis and medicinal chemistry, we used chemical proteomics to identify Sec61α (protein transport protein Sec61 subunit alpha isoform 1), the pore-forming subunit of the Sec61 protein translocon, as a direct binding partner of ipomoeassin ...
Tópico(s): Ubiquitin and proteasome pathways
2019 - American Chemical Society | Journal of the American Chemical Society
Mary S. Mufford, Josh W. Cheung, Neda Jahanshad, Celia van der Merwe, Linda Ding, Nynke A. Groenewold, Nastassja Koen, Emile R. Chimusa, Shareefa Dalvie, Raj Ramesar, James A. Knowles, Christine Löchner, Derrek P. Hibar, Peristera Paschou, Odile A. van den Heuvel, Sarah E. Medland, Jeremiah M. Scharf, Carol A. Mathews, Paul M. Thompson, Dan J. Stein,
There have been considerable recent advances in understanding the genetic architecture of Tourette syndrome (TS) as well as its underlying neurocircuitry. However, the mechanisms by which genetic variation that increases risk for TS-and its main symptom dimensions-influence relevant brain regions are poorly understood. Here we undertook a genome-wide investigation of the overlap between TS genetic risk and genetic influences on the volume of specific subcortical brain structures that have been implicated ...
Tópico(s): Trypanosoma species research and implications
2019 - Springer Nature | Translational Psychiatry
Dongmei Yu, Jae Hoon Sul, Fotis Tsetsos, Muhammad Sulaman Nawaz, Alden Y. Huang, Ivette Zelaya, Cornelia Illmann, Lisa Osiecki, Sabrina M. Darrow, Matthew E. Hirschtritt, Erica Greenberg, Kirsten Müller‐Vahl, Manfred Stuhrmann, Yves Dion, Guy A. Rouleau, H.N. Aschauer, M. Stamenković, Monika Schlögelhofer, Paul Sandor, Cathy L. Barr, Marco A. Grados, Harvey S. Singer, Markus M. Nöthen, Johannes Hebebrand, Anke Hinney, Robert A. King, Thomas Fernandez, Csaba Barta, Zsanett Tárnok, Péter Nagy, Christel Depienne, Yulia Worbe, Andreas Hartmann, Cathy L. Budman, Renata Rizzo, Gholson J. Lyon, William M. McMahon, James R. Batterson, Daniëlle C. Cath, Irene A. Malaty, Michael S. Okun, Cheston M. Berlin, Douglas W. Woods, Paul C. Lee, Joseph Jankovic, Mary M. Robertson, Donald L. Gilbert, Lawrence W. Brown, Barbara Coffey, Andrea Dietrich, Pieter J. Hoekstra, Samuel Kuperman, Samuel H. Zinner, Pétur Lúðvígsson, Evald Sæmundsen, Ólafur Thorarensen, Gil Atzmon, Nir Barzilai, Michael Wagner, Rainald Moessner, Roel A. Ophoff, Carlos N. Pato, Michele T. Pato, James A. Knowles, Joshua L. Roffman, Jordan W. Smoller, Randy L. Buckner, A. Jeremy Willsey, Jay A. Tischfield, Gary A. Heiman, Hreinn Stefánsson, Kári Stéfansson, Daniëlle Posthuma, Nancy J. Cox, David L. Pauls, Nelson B. Freimer, Benjamin M. Neale, Lea K. Davis, Peristera Paschou, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf,
Objective: Tourette's syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette's syndrome and other tic disorders. The authors conducted a GWAS meta-analysis and probed aggregated Tourette's syndrome polygenic risk to test whether Tourette's and related tic disorders have an underlying shared genetic etiology and whether Tourette's polygenic risk scores correlate with worst-ever tic ...
Tópico(s): Autism Spectrum Disorder Research
2019 - American Psychiatric Association | American Journal of Psychiatry
Valentina Baglioni, Estér Coutinho, David A. Menassa, Maria Pia Giannoccaro, Leslie Jacobson, Maura Buttiglione, O. Petruzzelli, Francesco Cardona, Angela Vincent, Zacharias Anastasiou, Alan Apter, Erika Bartolini, Noa Benaroya-Milshtein, Benjamin Bodmer, Emese Bognár, Bianka Burger, Marta Correa Vela, Roberta Creti, Andrea Dietrich, Nanette Mol Debes, Androulla Efstratiou, María Cristina Ferro, Carolin Fremer, Blanca García-Delgar, Maria Gariup, Marianthi Georgitsi, Mariangela Gulisano, Annelieke Hagen, Julie Hagstrøm, Tammy Hedderly, Isobel Heyman, Pieter J. Hoekstra, Chaim Huyser, Monica Imperi, Iordanis Karagiannidis, Giovanni Laviola, Simone Macrı̀, Marcos Madruga‐Garrido, Immaculada Margarit, A Marotta, Davide Di Martino, Ute‐Christiane Meier, Pablo Mir, Natalie Moll, Àstrid Morer, Kirsten Müller‐Vahl, Alexander Münchau, Péter Nagy, Valeria Neri, Thaïra J. C. Openneer, Graziella Orefici, Peristera Paschou, Alessandra Pellico, Cesare Porcelli, Marina Redondo, Renata Rizzo, P. Roazzi, Veit Roessner, Daphna Ruhrman, Jaana Schnell, Anette Schrag, Gregor Schütze, Markus Schwarz, Paola Rosaria Silvestri, Liselotte Skov, Tamar Steinberg, Sara Stöber, Marco Tallon, Zsanett Tárnok,
In Tourette Syndrome (TS) a role for autoantibodies directed against neuronal proteins has long been suspected, but so far results are still inconsistent. The aim of this study was to look for antibodies to specific or undefined neuronal proteins that could be involved in the aetiology of the disease. Sera from children with Tourette Syndrome or another chronic tic disorder (TS/TD), collected as part of the longitudinal European Multicenter Tics in Children Study, were investigated. Participants included ...
Tópico(s): Autoimmune Neurological Disorders and Treatments
2019 - Elsevier BV | Brain Behavior and Immunity
Alessandro Raveane, Serena Aneli, Francesco Montinaro, Georgios Athanasiadis, Simona Barlera, Giovanni Birolo, Giorgio B. Boncoraglio, Anna Maria Di Blasio, Cornelia Di Gaetano, Luca Pagani, Silvia Parolo, Peristera Paschou, Alberto Piazza, G Stamatoyannopoulos, Andrea Angius, Nicolas Brucato, Francesco Cucca, Garrett Hellenthal, Antonella Mulas, Marine Peyret-Guzzon, Magdalena Żołędziewska, Abdellatif Baali, Clare Bycroft, M. Cherkaoui, Jacques Chiaroni, Julie Di Cristofaro, Christian Dina, Jean-Michel Dugoujon, Pilar Galán, Joanna Giemza, Toomas Kivisild, Stéphane Mazières, Mohammed Melhaoui, Mait Metspalu, Simon Myers, Luı́sa Pereira, François‐Xavier Ricaut, Francesca Brisighelli, Irene Cardinali, Viola Grugni, Hovirag Lancioni, Vincenzo L. Pascali, Antonio Torroni, Ornella Semino, Giuseppe Matullo, Alessandro Achilli, Anna Olivieri, Cristian Capelli,
A population in a natural crossroad within Europe reveals multiple ancient contributions and substantial population structure.
Tópico(s): Race, Genetics, and Society
2019 - American Association for the Advancement of Science | Science Advances
Aritra Bose, Vassilis Kalantzis, Eugenia-Maria Kontopoulou, Mai Elkady, Peristera Paschou, Petros Drineas,
Abstract Motivation Principal Component Analysis is a key tool in the study of population structure in human genetics. As modern datasets become increasingly larger in size, traditional approaches based on loading the entire dataset in the system memory (Random Access Memory) become impractical and out-of-core implementations are the only viable alternative. Results We present TeraPCA, a C++ implementation of the Randomized Subspace Iteration method to perform Principal Component Analysis of large- ...
Tópico(s): Genetics and Plant Breeding
2019 - Oxford University Press | Bioinformatics
Phil H. Lee, Verneri Anttila, Hyejung Won, Yen‐Chen Anne Feng, Jacob Rosenthal, Zhaozhong Zhu, Elliot M. Tucker‐Drob, Michel G. Nivard, Andrew D. Grotzinger, Daniëlle Posthuma, Meg M.-J. Wang, Dongmei Yu, Eli A. Stahl, Raymond K. Walters, Richard Anney, Laramie E. Duncan, Tian Ge, Rolf Adolfsson, Tobias Banaschewski, Síntia Belangero, Edwin H. Cook, Giovanni Coppola, Eske M. Derks, Pieter J. Hoekstra, Jaakko Kaprio, Anna Keski‐Rahkonen, George Kirov, Henry R. Kranzler, Jurjen J. Luykx, Luís Augusto Rohde, Clement C. Zai, Esben Agerbo, María J. Arranz, Philip Asherson, Marie Bækvad‐Hansen, Gísli Baldursson, Mark A. Bellgrove, Richard A. Belliveau, Jan K. Buitelaar, Christie L. Burton, Jonas Bybjerg‐Grauholm, Miguel Casas, Felecia Cerrato, Kimberly Chambert, Tracy Air, Bru Cormand, Jennifer Crosbie, Søren Dalsgaard, Ditte Demontis, Alysa E. Doyle, Ashley Dumont, Josephine Elia, Jakob Grove, Ólafur Ó. Guðmundsson, Jan Haavik, Hákon Hákonarson, Christine Søholm Hansen, Catharina A. Hartman, Ziarih Hawi, Amaia Hervás, David M. Hougaard, Daniel P. Howrigan, Hailiang Huang, Jonna Kuntsi, K. Langley, Klaus‐Peter Lesch, Patrick W. L. Leung, Sandra K. Loo, Joanna Martin, Alicia R. Martin, James J. McGough, Sarah E. Medland, Jennifer L. Moran, Ole Mors, Preben Bo Mortensen, Robert D. Oades, Duncan S. Palmer, Carsten Bøcker Pedersen, Marianne G. Pedersen, Triinu Peters, Timothy Poterba, Jesper Buchhave Poulsen, Josep Antoni Ramos‐Quiroga, Andreas Reif, Marta Ribasés, Aribert Rothenberger, Paula Rovira, Cristina Sánchez‐Mora, F. Kyle Satterstrom, Russell Schachar, María Soler Artigas, Stacy Steinberg, Hreinn Stefánsson, Patrick Turley, G. Bragi Walters, Thomas Werge, Tetyana Zayats, Dan E. Arking, Francesco Bettella, Joseph D. Buxbaum, Jane Christensen, Ryan L. Collins, Hilary Coon, Silvia De Rubeis, Richard Delorme, Dorothy E. Grice, Thomas Hansen, Peter Holmans, Sigrun Hope, Christina M. Hultman, Lambertus Klei, Christine Ladd‐Acosta, Páll Magnússon, Terje Nærland, Mette Nyegaard, Dalila Pinto, Per Qvist, Karola Rehnström, Abraham Reichenberg, Jennifer Reichert, Kathryn Roeder, Guy A. Rouleau, Evald Sæmundsen, Stephan Sanders, Sven Sandin, Beaté St Pourcain, Kāri Stefánsson, James S. Sutcliffe, Michael E. Talkowski, Lauren A. Weiss, A. Jeremy Willsey, Ingrid Agartz, Huda Akil, Diego Albani, Martin Alda, Thomas D. Als, Adebayo Anjorin, Lena Backlund, Nicholas Bass, Michael Bauer, Bernhard T. Baune, Frank Bellivier, Sarah E. Bergen, Wade H. Berrettini, Joanna M. Biernacka, Douglas Blackwood, Erlend Bøen, Monika Budde, William E. Bunney, Margit Burmeister, William Byerley, Enda M. Byrne, Sven Cichon, Toni‐Kim Clarke, Jonathan R. I. Coleman, Nicholas Craddock, David Curtis, Piotr M. Czerski, Anders M. Dale, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Arianna Di Florio, Torbjørn Elvsåshagen, Bruno Étain, Sascha B. Fischer, Andreas J. Forstner, Liz Forty, Josef Frank, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Héléna A. Gaspar, Elliot S. Gershon, Michael Gill, Fernando S. Goes, Scott D. Gordon, Katherine Gordon‐Smith, Melissa J. Green, Tiffany A. Greenwood, Maria Grigoroiu‐Serbânescu, José Guzmán‐Parra, Joanna Hauser, Martin Hautzinger, Urs Heilbronner, Stefan Herms, Per Hoffmann, Dominic Holland, Stéphane Jamain, Ian Jones, Lisa Jones, Radhika Kandaswamy, John R. Kelsoe, James L. Kennedy, Oedegaard Ketil Joachim, Sarah Kittel‐Schneider, Manolis Kogevinas, Anna C. Koller, Catharina Lavebratt, Cathryn M. Lewis, Qingqin S. Li, Jolanta Lissowska, Loes M. Olde Loohuis, Susanne Lucae, Anna Maaser, Ulrik Fredrik Malt, Nicholas G. Martin, Lina Martinsson, Susan L. McElroy, Francis J. McMahon, Andrew McQuillin, Ingrid Melle, Andres Metspalu, Vincent Millischer, Philip B. Mitchell, Grant W. Montgomery, Gunnar Morken, Derek W. Morris, Bertram Müller‐Myhsok, Niamh Mullins, R Myers, Caroline M. Nievergelt, Merete Nordentoft, Annelie Nordin Adolfsson, Markus M. Nöthen, Roel A. Ophoff, Michael J. Owen, Sara A. Paciga, Carlos N. Pato, Michele T. Pato, Roy H. Perlis, Amy Perry, James B. Potash, Céline S. Reinbold, Marcella Rietschel, Margarita Rivera, Mary Roberson, Martin Schalling, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Engilbert Sigurðsson, Olav B. Smeland, Eystein Stordal, Fabian Streit, Jana Strohmaier, Thorgeir E. Thorgeirsson, Jens Treutlein, Gustavo Turecki, Arne E. Vaaler, Eduard Vieta, John B. Vincent, Yunpeng Wang, Stephanie H. Witt, Peter P. Zandi, Roger A.H. Adan, Lars Alfredsson, Tetsuya Ando, H.N. Aschauer, Jessica H. Baker, Vladimír Bencko, Andrew W. Bergen, Andreas Birgegård, Vesna Boraska Perica, Harry Brandt, Roland Burghardt, Laura Carlberg, Matteo Cassina, Maurizio Clementi, Philippe Courtet, Steven Crawford, Scott J. Crow, James J. Crowley, Unna N. Danner, Oliver S. P. Davis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Christian Dina, Elisa Docampo, Karin Egberts, Stefan Ehrlich, Thomas Espeseth, Fernando Fernández‐Aranda, Manfred M. Fichter, Lenka Foretová, Monica Forzan, Giovanni Gambaro, Ina Giegling, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Yiran Guo, Katherine A. Halmi, Konstantinos Hatzikotoulas,
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic ...
Cell Press
Anna Nyberg, Paraskevi Peristera, Linda L. Magnusson Hanson, Hugo Westerlund,
Objectives: To estimate trajectories of depression around old age retirement in Swedish women and men and examine if socio-economic status predicted the trajectoriesMethods: The analytic sample comprised 907 women and 806 men from the Swedish Longitudinal Occupational Survey of Health. B-spline smoothers and group-based trajectory modelling were used to identify groups of individuals with similar trajectories of depressive symptoms around retirement. Multinomial regression analyses were conducted ...
Tópico(s): Workplace Health and Well-being
2018 - Routledge | Aging & Mental Health
Sheng Wang, Jeffrey D. Mandell, Yogesh Kumar, Nawei Sun, Montana T. Morris, Juan David Arbelaez, Cara Nasello, Dong Shan, Clif Duhn, Xin Zhao, Zhiyu Yang, Shanmukha Sampath Padmanabhuni, Dongmei Yu, Robert A. King, Andrea Dietrich, Najah Khalifa, Niklas Dahl, Alden Y. Huang, Benjamin M. Neale, Giovanni Coppola, Carol A. Mathews, Jeremiah M. Scharf, Thomas Fernandez, Joseph D. Buxbaum, Silvia De Rubeis, Dorothy E. Grice, Jinchuan Xing, Gary A. Heiman, Jay A. Tischfield, Peristera Paschou, A. Jeremy Willsey, Matthew W. State,
(Cell Reports 24, 3441–3454.e1–e12; September 25, 2018) In the originally published version of this article, the secondary author list detailing authors from the associated consortia was omitted due a miscommunication. The secondary author list has now been included with the article online. Cell Press apologizes for this miscommunication. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in PathogenesisWang et al.Cell ReportsSeptember ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2018 - Cell Press | Cell Reports
Paraskevi Peristera, Hugo Westerlund, Linda L. Magnusson Hanson,
Long working hours and unpaid work are possible risk factors for depressive symptoms. However, little is known about how working hours influence the course of depressive symptoms. This study examined the influence of paid, unpaid working hours and total working hours on depressive symptoms trajectories.
Tópico(s): Health, psychology, and well-being
2018 - BMJ | BMJ Open
Verneri Anttila, Brendan Bulik‐Sullivan, Hilary K. Finucane, Raymond K. Walters, José Brás, Laramie E. Duncan, Valentina Escott‐Price, Guido J. Falcone, Padhraig Gormley, Rainer Malik, Nikolaos A. Patsopoulos, Stephan Ripke, Zhi Wei, Dongmei Yu, Phil H. Lee, Patrick Turley, Benjamin Grenier‐Boley, Vincent Chouraki, Yoichiro Kamatani, Claudine Berr, Luc Letenneur, Didier Hannequin, Philippe Amouyel, Anne Boland, Jean‐François Deleuze, Emmanuelle Duron, Badri N. Vardarajan, Christiane Reitz, Alison Goate, Matthew J. Huentelman, M. Ilyas Kamboh, Eric B. Larson, Ekaterina Rogaeva, Peter St George‐Hyslop, Hákon Hákonarson, Walter A. Kukull, Lindsay A. Farrer, Lisa L. Barnes, Thomas G. Beach, F. Yesim Demirci, Elizabeth Head, Christine M. Hulette, Gregory A. Jicha, John S.K. Kauwe, Jonathan Kaye, James B. Leverenz, Allan I. Levey, Andrew P. Lieberman, V. Shane Pankratz, Wayne W. Poon, Joseph F. Quinn, Andrew J. Saykin, Lon S. Schneider, Amanda Smith, Joshua A. Sonnen, Robert A. Stern, Vivianna M. Van Deerlin, Linda J. Van Eldik, Denise Harold, Giancarlo Russo, David C. Rubinsztein, Antony Bayer, Magda Tsolaki, Petroula Proitsi, Nick C. Fox, Harald Hampel, Michael J. Owen, Simon Mead, Peter Passmore, Kevin Morgan, Markus M. Nöthen, Jonathan M. Schott, Martin N. Rossor, Michelle K. Lupton, Per Hoffmann, Johannes Kornhuber, Brian Lawlor, Andrew McQuillin, Ammar Al‐Chalabi, Joshua C. Bis, Agustı́n Ruiz, Merçé Boada, Sudha Seshadri, Alexa Beiser, Kenneth Rice, Sven J. van der Lee, Philip L. De Jager, Daniel H. Geschwind, Markus J. Riemenschneider, Steffi G. Riedel‐Heller, Jerome I. Rotter, Gerhard Ransmayr, Bradley T. Hyman, Carlos Cruchaga, Montserrat Alegret, Bendik S. Winsvold, Priit Palta, Kai-How Farh, Ester Cuenca-León, Nicholas A. Furlotte, Tobias Kurth, Lannie Ligthart, Gisela M. Terwindt, Tobias Freilinger, Caroline Ran, Scott D. Gordon, Guntram Borck, Hieab H.H. Adams, Terho Lehtimäki, Juho Wedenoja, Julie E. Buring, Markus Schürks, Maria Gudlaug Hrafnsdottir, Jouke‐Jan Hottenga, Brenda W.J.H. Penninx, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Nicholas G. Martin, Grant W. Montgomery, Mitja Kurki, Eija Hämäläinen, Hailiang Huang, Jie Huang, Cynthia Sandor, Caleb Webber, Bertram Müller‐Myhsok, Stefan Schreiber, Veikko Salomaa, Elizabeth Loehrer, Hartmut Göbel, Alfons Macaya, Patricia Pozo‐Rosich, Thomas Hansen, Thomas Werge, Jaakko Kaprio, Andres Metspalu, Christian Kubisch, Michel D. Ferrari, Andrea Carmine Belin, Arn M. J. M. van den Maagdenberg, John‐Anker Zwart, Dorret I. Boomsma, Nicholas Eriksson, Jes Olesen, Daniel I. Chasman, Dale R. Nyholt, Richard Anney, Andreja Avberšek, Larry Baum, Samuel F. Berkovic, Jonathan P. Bradfield, Russell J. Buono, Claudia B. Catarino, Patrick Cossette, Peter De Jonghe, Chantal Depondt, Dennis Dlugos, Thomas N. Ferraro, Jacqueline A. French, Helle Hjalgrim, Jennifer Jamnadas-Khoda, Reetta Kälviäinen, Wolfram S. Kunz, Holger Lerche, Costin Leu, Dick Lindhout, Warren Lo, Daniel H. Lowenstein, Mark McCormack, Rikke S. Møller, Anne M. Molloy, Ping-Wing Ng, Karen Oliver, Michael Privitera, Rodney A. Radtke, Ann‐Kathrin Ruppert, Thomas Sander, Steven C. Schachter, Christoph J. Schankin, Ingrid E. Scheffer, Susanne Schoch, Sanjay M. Sisodiya, Phil E M Smith, Michael R. Sperling, Pasquale Striano, Rainer Surges, G. Neil Thomas, Frank Visscher, Christopher D. Whelan, Federico Zara, Erin L. Heinzen, Anthony G Marson, Felicitas Becker, Hans Stroink, Fritz Zimprich, Thomas Gasser, J. Raphael Gibbs, Peter Heutink, María Martínez, Huw R. Morris, Manu Sharma, Mina Ryten, Kin Y. Mok, Sara L. Pulit, Steve Bevan, Elizabeth G. Holliday, John Attia, Thomas W.K. Battey, Giorgio B. Boncoraglio, Vincent Thijs, Wei‐Min Chen, Braxton D. Mitchell, Peter M. Rothwell, Pankaj Sharma, Cathie Sudlow, Astrid M. Vicente, Hugh S. Markus, Christina Kourkoulis, Joanna Pera, Miriam R. Raffeld, Scott Silliman, Vesna Boraska Perica, Laura M. Thornton, Laura M. Huckins, N. William Rayner, Cathryn M. Lewis, Mónica Gratacòs, Filip Rybakowski, Anna Keski‐Rahkonen, Anu Raevuori, James I. Hudson, Ted Reichborn‐Kjennerud, Palmiero Monteleone, Andreas Karwautz, Katrin Männik, Jessica H. Baker, Julie K. O’Toole, Sara E. Trace, Oliver S. P. Davis, Sietske G. Helder, Stefan Ehrlich, Beate Herpertz‐Dahlmann, Unna N. Danner, Annemarie Elburg, Maurizio Clementi, Monica Forzan, Elisa Docampo, Jolanta Lissowska, Joanna Hauser, Alfonso Tortorella, Mario Maj, Fragiskos Gonidakis, Konstantinos Tziouvas, Hana Papežová, Zeynep Yılmaz, Gudrun Wagner, Sarah Cohen‐Woods, Stefan Herms, Antonio Julià, Raquel Rabionet, Danielle M. Dick, Samuli Ripatti, Ole A. Andreassen, Thomas Espeseth, Astri J. Lundervold, Vidar M. Steen, Dalila Pinto, Stephen W. Scherer, H.N. Aschauer, Alexandra Schosser, Lars Alfredsson, Leonid Padyukov, Katherine A. Halmi, James E. Mitchell, Michael Strober, Andrew W. Bergen, Walter H. Kaye, Jin P. Szatkiewicz, Bru Cormand, Josep Antoni Ramos‐Quiroga, Cristina Sánchez‐Mora, Marta Ribasés, Miguel Casas, Amaia Hervás, María J. Arranz, Jan Haavik, Tetyana Zayats, Stefan Johansson, Nigel Williams, Josephine Elia, Astrid Dempfle, Aribert Rothenberger, Jonna Kuntsi, Robert D. Oades, Tobias Banaschewski,
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from ...
American Association for the Advancement of Science
Anette Schrag, Davide Martino, Alan Apter, Juliane Ball, Erika Bartolini, Noa Benaroya-Milshtein, Maura Buttiglione, Francesco Cardona, Roberta Creti, Androulla Efstratiou, Maria Gariup, Marianthi Georgitsi, Tammy Hedderly, Isobel Heyman, Immaculada Margarit, Pablo Mir, Natalie Moll, Àstrid Morer, Norbert Müller, Kirsten Müller‐Vahl, Alexander Münchau, Graziella Orefici, Kerstin Jessica Plessen, Cesare Porcelli, Peristera Paschou, Renata Rizzo, Veit Roessner, Markus Schwarz, Tamar Steinberg, Friederike Tagwerker Gloor, Zsanett Tárnok, Susanne Walitza, Andrea Dietrich, Pieter J. Hoekstra,
Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological vulnerability to the development of tics and associated behaviours. However, the existing evidence for this relies primarily on small prospective or larger retrospective population-based studies, and is therefore still inconclusive. This article describes the design and methodology ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2018 - Springer Science+Business Media | European Child & Adolescent Psychiatry
Özlem Bülbül, A.J. Pakstis, Usha Soundararajan, Cemal Gürkan, Jane E. Brissenden, Janet Roscoe, Baigalmaa Evsanaa, Ariunaa Togtokh, Peristera Paschou, Elena L. Grigorenko, David Gurwitz, Sharon Wootton, Robert Lagacé, Joseph Chang, William C. Speed, Kenneth K. Kídd,
Microhaplotypes have become a new type of forensic marker with a great ability to identify and deconvolute mixtures because massively parallel sequencing (MPS) allows the alleles (haplotypes) of the multi-SNP loci to be determined directly for an individual. As originally defined, a microhaplotype locus is a short segment of DNA with two or more SNPs defining three or more haplotypes. The length is short enough, less than about 300 bp, that the read length of current MPS technology can produce a phase- ...
Tópico(s): Genomics and Phylogenetic Studies
2017 - Springer Science+Business Media | International Journal of Legal Medicine
Eirini I. Agianniotaki, Élisabeth Mathijs, Frank Vandenbussche, Konstantia E. Tasioudi, Andy Haegeman, Peristera Iliadou, Serafeim C. Chaintoutis, Chrysostomos Ι. Dovas, Steven Van Borm, Eleni Chondrokouki, Kris De Clercq,
Lumpy skin disease virus (LSDV) causes an economically important disease in cattle. Here, we report the complete genome sequence of the first LSDV isolate identified in mainland Europe. LSDV isolate Evros/GR/15 was isolated from the first cases reported on 18 August 2015 in the Evros region, Greece.
Tópico(s): Bacteriophages and microbial interactions
2017 - American Society for Microbiology | Genome Announcements
Alden Y. Huang, Dongmei Yu, Lea K. Davis, Jae Hoon Sul, Fotis Tsetsos, Vasily Ramensky, Ivette Zelaya, Eliana Marisa Ramos, Lisa Osiecki, Jason Chen, Lauren M. McGrath, Cornelia Illmann, Paul Sandor, Cathy L. Barr, Marco A. Grados, Harvey S. Singer, Markus M. Nöthen, Johannes Hebebrand, Robert A. King, Yves Dion, Guy A. Rouleau, Cathy L. Budman, Christel Depienne, Yulia Worbe, Andreas Hartmann, Kirsten Müller‐Vahl, Manfred Stuhrmann, H.N. Aschauer, M. Stamenković, Monika Schloegelhofer, Anastasios Konstantinidis, Gholson J. Lyon, William M. McMahon, Csaba Barta, Zsanett Tárnok, Péter Nagy, James R. Batterson, Renata Rizzo, Daniëlle C. Cath, Tomasz Wolañczyk, Cheston M. Berlin, Irene A. Malaty, Michael S. Okun, Douglas W. Woods, Elliott Rees, Carlos N. Pato, Michele T. Pato, James A. Knowles, Daniëlle Posthuma, David L. Pauls, Nancy J. Cox, Benjamin M. Neale, Nelson B. Freimer, Peristera Paschou, Carol A. Mathews, Jeremiah M. Scharf, Giovanni Coppola, Ruth D. Bruun, Sylvain Chouinard, Sabrina M. Darrow, Erica Greenberg, Matthew E. Hirschtritt, Roger Kurlan, James F. Leckman, Mary M. Robertson, Johannes H. Smit,
Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal development and/or maintenance of cortico-striato-thalamo-cortical circuits. TS is highly heritable, but its underlying genetic causes are still elusive, and no genome-wide significant loci have been discovered to date. We analyzed a European ancestry sample of 2,434 TS cases and 4,093 ancestry-matched controls for rare (< 1% frequency) copy-number variants (CNVs) using SNP microarray data. We observed an enrichment ...
Tópico(s): Williams Syndrome Research
2017 - Cell Press | Neuron