Oruç Köklükaya, Rose-Marie Pernilla Karlsson, Federico Carosio, Lars Wågberg,
Layer-by-Layer (LbL) assembled nanocoatings are exploited to impart flame-retardant properties to cellulosic substrates. A model cellulose material can make it possible to investigate an optimal bilayer (BL) range for the deposition of coating while elucidating the main flame-retardant action thus allowing for an efficient design of optimized LbL formulations. Model cellulose gel beads were prepared by dissolving cellulose-rich fibers followed by precipitation. The beads were LbL-treated with chitosan ( ...
Tópico(s): Surface Modification and Superhydrophobicity
2020 - Elsevier BV | Carbohydrate Polymers
Rose-Marie Pernilla Karlsson, Per Tomas Larsson, Torbjörn Pettersson, Lars Wågberg,
Cellulose-based model materials in the form of fibrillar networks and macromolecular hydrogels were used to investigate the ion-induced swelling in relation to the elasticity and structure of the network. Both networks were charged by the introduction of carboxyl groups onto the cellulose surface, and the dimensions of the networks in aqueous solution were measured as a function of pH. The use of cellulose-model materials that contained either noncrystalline cellulose or cellulose I fibrils made ...
Tópico(s): Polysaccharides and Plant Cell Walls
2020 - American Chemical Society | Langmuir
Rose-Marie Pernilla Karlsson, Per Tomas Larsson, Per Hansson, Lars Wågberg,
Noncrystalline cellulose-based gel beads were used as a model material to investigate the effect of osmotic stress on a cellulosic network. The gel beads were exposed to osmotic stress by immersion in solutions with different concentrations of high molecular mass dextran and the equilibrium dimensional change of the gel beads was studied using optical microscopy. The volume fraction of cellulose was calculated from the volume of the gel beads in dextran solutions and their dry content and the relation ...
Tópico(s): Hydrogels: synthesis, properties, applications
2019 - American Chemical Society | Biomacromolecules
Rose-Marie Pernilla Karlsson, Per Tomas Larsson, Shun Yu, Samuel A. Pendergraph, Torbjörn Pettersson, Johannes Hellwig, Lars Wågberg,
Macroscopic beads of water-based gels consisting of uncharged and partially charged β-(1,4)-d-glucan polymers were developed to be used as a novel model material for studying the water induced swelling of the delignified plant fiber walls. The gel beads were prepared by drop-wise precipitation of solutions of dissolving grade fibers carboxymethylated to different degrees. The internal structure was analyzed using Solid State Cross-Polarization Magic Angle Spinning Carbon-13 Nuclear Magnetic Resonance ...
Tópico(s): Natural Fiber Reinforced Composites
2018 - Elsevier BV | Journal of Colloid and Interface Science
Tanja Gustafsson, Annelie J. Sundler, Elisabeth Lindberg, Pernilla Karlsson, Hanna Maurin Söderholm,
Abstract Background There is currently a strong emphasis on person-centred care (PCC) and communication; however, little research has been conducted on how to implement person-centred communication in home care settings. Therefore, the ACTION (A person-centred CommunicaTION) programme, which is a web-based education programme focusing on person-centred communication developed for nurse assistants (NAs) providing home care for older persons, was implemented. This paper reports on the process evaluation ...
Tópico(s): Geriatric Care and Nursing Homes
2021 - BioMed Central | BMC Nursing
Elisabeth Lindberg, Pernilla Karlsson, Susanne Knutsson,
Creative strategies are needed in nurse education to integrate theory, practice and lived experiences. Towards that end, reflective seminars, conducted in congruence with reflective lifeworld theory and caring science, were implemented during a three-year nursing programme. The reflection seminars took place during the theoretical parts of education and the clinical placements. Each reflection group consisted of six to nine students, and the seminars were led by a lecturer from the university. This ...
Tópico(s): Reflective Practices in Education
2017 - Elsevier BV | Nurse Education Today
Hedwig Widestedt, Jasna Giesecke, Pernilla Karlsson, Jan Jakobsson,
Background: Cardiac arrest requires rapid and effective handling. Huge efforts have been implemented to improve resuscitation of sudden cardiac arrest patients. Guidelines around the various parts of effective management, the chain of survival , are available. The aim of the present retrospective study was to study sudden in-hospital cardiac arrest (IHCA) and the outcomes of emergence team resuscitation in a university hospital in Sweden. Methods: The Swedish Cardiopulmonary Resuscitation Registry was used to ...
Tópico(s): Healthcare Technology and Patient Monitoring
2018 - Faculty of 1000 | F1000Research
L. Renee Ruhaak, Jenny Felth, Pernilla C. Karlsson, Joseph Rafter, Robert Verpoorte, Lars Bohlin,
Cyclooxygenase enzymes (COX-1 and COX-2) catalyse the production of prostaglandins from arachidonic acid. Prostaglandins are important mediators in the inflammatory process and their production can be reduced by COX-inhibitors. Endocannabinoids, endogenous analogues of the plant derived cannabinoids, occur normally in the human body. The Endocannabinoids are structurally similar to arachidonic acid and have been suggested to interfere with the inflammatory process. They have also been shown to inhibit ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2011 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Jenny Pettersson, Pernilla C. Karlsson, Ulf Göransson, Joseph Rafter, Lars Bohlin,
Many phytochemicals found in the diet may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Inflammation and subsequent elevation of the enzyme cyclooxygenase-2 (COX-2) are two such factors involved in the development of colon cancer, and inhibition of these processes could be important targets for chemoprevention. We have previously shown COX-2 inhibitory activity locally in the colon; e.g. in human fecal water from a group of vegetarians. In this study we focus ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
2008 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Jenny Pettersson, Pernilla C. Karlsson, Young Hae Choi, Robert Verpoorte, Joseph Rafter, Lars Bohlin,
A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin production and COX-2 protein expression in colonic cells. The aim with the present study was to further study the composition of the fecal waters, using ...
Tópico(s): Food Quality and Safety Studies
2008 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Annett Klinder, Pernilla C. Karlsson, Yvonne Clune, Róisín Hughes, Michael Glei, Joseph Rafter, Ian Rowland, John Collins, Beatrice L. Pool‐Zobel,
Abstract: The assessment of cellular effects by the aqueous phase of human feces (fecal water, FW) is a useful biomarker approach to study cancer risks and protective activities of food. In order to refine and develop the biomarker, different protocols of preparing FW were compared. Fecal waters were prepared by 3 methods: (A) direct centrifugation; (B) extraction of feces in PBS before centrifugation; and (C) centrifugation of lyophilized and reconstituted feces. Genotoxicity was determined in colon ...
Tópico(s): Wastewater Treatment and Reuse
2007 - Routledge | Nutrition and Cancer
Joseph Rafter, Michael Bennett, Giovanna Caderni, Yvonne Clune, Róisín Hughes, Pernilla C. Karlsson, Annett Klinder, Micheal O'Riordan, Gerald C. O’Sullivan, Beatrice L. Pool‐Zobel, Gerhard Rechkemmer, Monika Roller, Ian Rowland, Maddalena Salvadori, Herbert Thijs, Jan Van Loo, Bernhard Watzl, John Collins,
Tópico(s): Digestive system and related health
2007 - Elsevier BV | American Journal of Clinical Nutrition
Pernilla C. Karlsson, Ulrika Huss, Andrew M. Jenner, Barry Halliwell, Lars Bohlin, Joseph Rafter,
The inducible enzyme cyclooxygenase-2 (COX-2) plays a major role in the regulation of inflammation and possibly in the development of colon cancer. The aim of the present study was to screen for COX-2 inhibitors in samples of fecal water (the aqueous phase of feces) and investigate whether phenolic compounds are responsible for any observed effects on COX-2. Volunteers (n = 20) were recruited and asked to supply a 24-h stool sample. Fecal water samples were prepared and analyzed by GC-MS for their content ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2005 - Elsevier BV | Journal of Nutrition
Pernilla C. Karlsson, Róisín Hughes, Joseph Rafter, W. Robert Bruce,
Polyethylene glycol 8000 inhibits the formation of tumors and of aberrant crypt foci (ACF) in carcinogen-initiated rats. We asked: is the inhibition associated with a reduction of colonic inflammation and an increase in colonic cell permeability? Twenty-eight, male F 344 rats were divided into two groups, 10 control animals and 18 animals initiated with azoxymethane. Nine of the rats in the carcinogen-initiated group were given a diet with 5% PEG 8000 in an AIN-93 based, high fat diet. The other ...
Tópico(s): Colorectal Cancer Screening and Detection
2004 - Elsevier BV | Cancer Letters
Mirjam M. Nordling, Björn Glinghammar, Pernilla C. Karlsson, Theo M. de Kok, Joseph Rafter,
The free water phase of feces (fecal water) may mediate the effects of diet on colon carcinogenesis. We examined the effects of fecal water from adenoma patients and controls on three parameters in colonocytes believed to be relevant to tumorigenesis, i.e. genotoxicity in intact cells and on isolated DNA, proliferative activity and activator protein-1 (AP-1) activity.Genotoxicity in intact colonic cells was assayed using the single-cell gel electrophoresis assay ('comet' assay) and on isolated DNA using ...
Tópico(s): Colorectal Cancer Screening and Detection
2003 - Taylor & Francis | Scandinavian Journal of Gastroenterology
Lars‐Âke Fransson, Pernilla C. Karlsson, Artur Schmidtchen,
(1) We have isolated radiolabelled proteoglycans and glycosaminoglycans produced by human embryonic skin fibroblasts in the presence of (a) cycloheximide to inhibit protein synthesis or (b) brefeldin A to impede transport between the endoplasmic reticulum and the Golgi complex or (c) suramin, heparin or primaquine to interfere with internalization, recycling and degradation. Effects on glycosaminoglycan synthesis were assayed separately by using exogenous p-nitrophenyl beta-D-xylopyranoside (and [3H] ...
Tópico(s): Fibroblast Growth Factor Research
1992 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Pernilla Karlsson, J. Dobbin McNatt, Steve Verrill,
Vacuum-pressure soak (VPS) at room temperature was investigated as an alternative to the hot water soak and steaming steps in the current ASTM D 1037 accelerated-aging tests. Oriented strandboard, flakeboard, isocyanate-bonded particleboard, and hardboard siding were included. The effects of steaming and cyclic hot water soak plus ovendry (OD) exposure were also investigated. For the phenolic-bonded flakeboard, the various alternative exposures had essentially the same effect on static bending and ...
Tópico(s): Structural Analysis of Composite Materials
1996 - Forest Products Society | Forest Products Journal
Pernilla Tidåker, Hanna Karlsson, Georg Carlsson, Elin Röös,
Pulses are important components in sustainable diets and cropping systems. This study evaluated the environmental impact of cultivation of five Swedish pulses (yellow peas, grey peas, faba beans, common beans and lentils) in a life-cycle perspective. The impact of selected Swedish pulses (conventional or organic) was then compared with that of imported pulses in Sweden, including contributions from processing, packaging and transport. The influence of origin and transportation mode and differences ...
Tópico(s): Organic Food and Agriculture
2021 - Elsevier BV | Sustainable Production and Consumption
Pernilla Nilsson, Göran Karlsson,
During the last decades, digital technologies have become more common in providing opportunities for reflection and in-depth analysis of classroom practices and have afforded new ways of organising teacher education. In particular, videotaped lessons have proven to be a valuable tool for capturing teaching episodes, subsequent reflection and development of student teachers' professional knowledge, here referred to as 'pedagogical content knowledge' (PCK). The aim of this project was to investigate ...
Tópico(s): Educational Tools and Methods
2018 - Taylor & Francis | International Journal of Science Education
Sven‐Olof Yrjö Collin, Jenny Ahlberg, Karin Berg, Pernilla Broberg, Amelie Karlsson,
Purpose The purpose of this paper is to develop and test a concept of auditor as consigliere in family firms, that captures additional functions to monitoring, those of advice, mediating, and conveying. Design/methodology/approach The concept is tested through a survey conducted on 309 Swedish auditors. Findings The data indicate that the consigliere role is generally not emphasized, indicating that auditors primarily perform the monitoring role of the audit. However, the authors do find indications ...
Tópico(s): Corporate Taxation and Avoidance
2017 - Emerald Publishing Limited | Journal of Family Business Management
Adam S. Darwich, Alison Margolskee, Xavier Pépin, Leon Aarons, Aleksandra Galetin, Amin Rostami‐Hodjegan, Sara Carlert, Maria Hammarberg, Constanze Hilgendorf, Pernilla Johansson, Εva Karlsson, Donal B. Murphy, Christer Tannergren, Helena Thörn, Mohammed Yasin, Florent Mazuir, Olivier Nicolas, Sergej Ramusovic, Christine Xu, Shriram M. Pathak, Timo Korjamo, Johanna Laru, J. Malkki, Sari Pappinen, Johanna Tuunainen, Jennifer B. Dressman, Simone Hansmann, Edmund Kostewicz, Handan He, Tycho Heimbach, Fan Wu, Carolin Hoft, Yan Pang, Michael B. Bolger, Eva Huehn, Viera Lukáčová, James M. Mullin, Ke Szeto, Chester Costales, Jian Lin, Mark McAllister, Sweta Modi, Charles J. Rotter, Manthena V. S. Varma, Mei Wong, Amitava Mitra, Jan Bevernage, Jeike Biewenga, Achiel Van Peer, Richard Lloyd, Carole Shardlow, Peter Langguth, Irina Mishenzon, Mai Ánh Nguyễn, Jonathan Brown, Hans Lennernäs, Bertil Abrahamsson,
Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded "bottom-up" anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal ...
Tópico(s): Pharmaceutical studies and practices
2016 - Elsevier BV | European Journal of Pharmaceutical Sciences
Alison Margolskee, Adam S. Darwich, Xavier Pépin, Leon Aarons, Aleksandra Galetin, Amin Rostami‐Hodjegan, Sara Carlert, Maria Hammarberg, Constanze Hilgendorf, Pernilla Johansson, Εva Karlsson, Donal B. Murphy, Christer Tannergren, Helena Thörn, Mohammed Yasin, Florent Mazuir, Olivier Nicolas, Sergej Ramusovic, Christine Xu, Shriram M. Pathak, Timo Korjamo, Johanna Laru, J. Malkki, Sari Pappinen, Johanna Tuunainen, Jennifer B. Dressman, Simone Hansmann, Edmund Kostewicz, Handan He, Tycho Heimbach, Fan Wu, Carolin Hoft, Loïc Laplanche, Yan Pang, Michael B. Bolger, Eva Huehn, Viera Lukáčová, James M. Mullin, Ke Szeto, Chester Costales, Jian Lin, Mark McAllister, Sweta Modi, Charles J. Rotter, Manthena V. S. Varma, Mei Wong, Amitava Mitra, Jan Bevernage, Jeike Biewenga, Achiel Van Peer, Richard Lloyd, Carole Shardlow, Peter Langguth, Irina Mishenzon, Mai Ánh Nguyễn, Jonathan Brown, Hans Lennernäs, Bertil Abrahamsson,
Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation development by providing quantitative predictions through a systems approach. The performance of three available PBPK software packages (GI-Sim, Simcyp®, and GastroPlus™) were evaluated by comparing simulated and observed pharmacokinetic (PK) parameters. ...
Tópico(s): Analytical Methods in Pharmaceuticals
2016 - Elsevier BV | European Journal of Pharmaceutical Sciences
Karin Sävman, Melvyn P. Heyes, Pernilla Svedin, Anna Karlsson,
Activation of microglia/macrophages is important in neonatal hypoxic-ischemic (HI) brain injury. Based on experimental studies, we identified macrophage/microglia-derived mediators with potential neurotoxic effects after neonatal HI and examined them in cerebrospinal fluid (CSF) from newborn infants after birth asphyxia. Galectin-3 is a novel inflammatory mediator produced by microglia/macrophages. Galectin-3 is chemotactic for inflammatory cells and activates nicotinamide adenine dinucleotide phosphate ( ...
Tópico(s): Aortic Disease and Treatment Approaches
2012 - Springer Science+Business Media | Translational Stroke Research
Pernilla Roxin, Anders Karlsson, Satish K. Singh,
Cellulose acetate phthalate (CAP) is a commonly used enteric coating polymer. CAP powder has been studied by various methods to determine characteristics that have an influence on its functionality. While some of the parameters are well known, such as free-acid content and substituent composition, new methods have been developed to examine them. Other characteristics, such as the molecular mass distribution, have not been reported earlier. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic ...
Tópico(s): Polymer Science and PVC
1998 - Taylor & Francis | Drug Development and Industrial Pharmacy
Sara Lysholm, Johanna F. Lindahl, George Dautu, Elin Johansson, Pernilla Karlsson Bergkvist, Musso Munyeme, Jonas Johansson Wensman,
Transboundary pathogens of goats present significant constraints to the livelihoods of millions of farmers in countries such as Zambia. Consequently, this study aimed to investigate the seroprevalence of Mycoplasma capricolum subsp. capripneumoniae (Mccp), foot and mouth disease virus (FMDV), Brucella spp., Crimean Congo haemorrhagic fever virus (CCHFV), and Rift Valley fever virus (RVFV) in Zambian goats. Another aim was to identify associations between seroprevalence and different predictor variables, ...
Tópico(s): Animal Disease Management and Epidemiology
2022 - Elsevier BV | Preventive Veterinary Medicine
Karin von Greyerz, Pernilla Tidåker, Johan O. Karlsson, Elin Röös,
Domesticated ruminants supply nutrient-dense foods but at a large environmental cost. However, many ruminant production systems are multi-functional, providing ecosystem services (ES) other than direct provision of food. When quantifying the climate impact of ruminant products using life cycle assessment (LCA), provisioning ES (i.e. beef and milk) are generally considered the only valuable outputs and other ES provided are ignored, which risks overlooking positive contributions associated with ruminant ...
Tópico(s): Effects of Environmental Stressors on Livestock
2022 - Elsevier BV | Journal of Environmental Management
Johan O. Karlsson, Pernilla Tidåker, Elin Röös,
Abstract To balance trade-offs between livestock’s negative environmental impacts and their positive contributions (e.g. maintaining semi-natural grasslands, varied agricultural landscapes and crop rotations), a better understanding is needed of how the supply of ecosystem services differs across farms. We analysed a suite of indicators for non-provisioning ecosystem services on a large subset of Swedish farms (71% of farms, covering 82% of agricultural land) and related these to farm type, farm size ...
Tópico(s): Land Use and Ecosystem Services
2022 - Springer Science+Business Media | AMBIO
Camilla C. Karlsson, Pernilla Dahm‐Kähler, Niclas Kvarnström, Johan Mölne, Verena Broecker, Mats Brännström,
The first live birth after uterus transplantation occurred in Sweden in 2014. Uterus transplantation has repeatedly, and at many centers worldwide, proven to be a feasible treatment for absolute uterine factor infertility. Hysterectomy in live donors and transplantation are well described in numerous reports. However, there are no reports of hysterectomy in the recipient after uterus transplantation, which will occur at either graft failure, after childbirth, or after numerous failed pregnancy attempts. ...
Tópico(s): Reconstructive Surgery and Microvascular Techniques
2021 - Informa | Acta Obstetricia Et Gynecologica Scandinavica
Tanja Gustafsson, Hanna Maurin Söderholm, Annelie J. Sundler, Pernilla Karlsson, Elisabeth Lindberg,
Abstract Aim To explore nursing assistants' (NAs') experiences of developing communication skills while participating in an educational intervention on person‐centred communication. Design A descriptive qualitative study was conducted. Methods Data were collected from interviews and written assignments before, during and after an educational intervention on person‐centred communication targeting NAs in home care services. The data were analysed using a phenomenological approach. A total of 25 NAs ...
Tópico(s): Geriatric Care and Nursing Homes
2023 - Wiley | Nursing Open
R. Einarsson, Rose-Marie Pernilla Karlsson, Eva Åkerblom,
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
1984 - Elsevier BV | Journal of Chromatography A