Zeev Shmelzer, Maria Karter, Miriam Eisenstein, Thomas L. Leto, Nurit Hadad, David Ben-Menahem, Daniel Gitler, Shirly Banani, Baruch Wolach, Meir Rotem, Rachel Lévy,
... recent study (25Shmelzer Z. Haddad N. Admon E. Pessach I. Leto T.L. Eitan-Hazan Z. Hershfinkel ... by PMA (25Shmelzer Z. Haddad N. Admon E. Pessach I. Leto T.L. Eitan-Hazan Z. Hershfinkel ... described earlier (25Shmelzer Z. Haddad N. Admon E. Pessach I. Leto T.L. Eitan-Hazan Z. Hershfinkel ... 5 × 107 (25Shmelzer Z. Haddad N. Admon E. Pessach I. Leto T.L. Eitan-Hazan Z. Hershfinkel ... Google Scholar, 25Shmelzer Z. Haddad N. Admon E. Pessach I. Leto T.L. Eitan-Hazan Z. Hershfinkel ...
Tópico(s): Nitric Oxide and Endothelin Effects
2008 - Elsevier BV | Journal of Biological Chemistry
Vered Molho‐Pessach, José Antonio Suárez, Christophe Perrin, C. Chiavérini, Victoria Doviner, Enriqueta Tristán‐Clavijo, Isabel Colmenero, Fabienne Giuliano, Antonio Torrelo, Abraham Zlotogorski,
... low height and hyperglycemia/diabetes mellitus [ 1 Molho-Pessach V. Agha Z. Aamar S. Glaser B. Doviner ... PDF PubMed Scopus (95) Google Scholar , 2 Molho-Pessach V. Lerer I. Abeliovich D. Agha Z. Abu ... in press. Google Scholar ]. Recently, we [ [2] Molho-Pessach V. Lerer I. Abeliovich D. Agha Z. Abu ...
Tópico(s): Pancreatic function and diabetes
2009 - Elsevier BV | Journal of Dermatological Science
... system (CNS). Lafaille et al., 2012Lafaille F.G. Pessach I.M. Zhang S.Y. Ciancanelli M.J. ... system (CNS). Lafaille et al., 2012Lafaille F.G. Pessach I.M. Zhang S.Y. Ciancanelli M.J. ... recent study, Lafaille et al., 2012Lafaille F.G. Pessach I.M. Zhang S.Y. Ciancanelli M.J. ... viral control. Lafaille et al., 2012Lafaille F.G. Pessach I.M. Zhang S.Y. Ciancanelli M.J. ...
Tópico(s): RNA regulation and disease
2012 - Cell Press | Cell Host & Microbe
Shirli Israeli, Yakov Pessach, Ofer Sarig, Ilan Goldberg, Eli Sprecher,
... this author on: Oxford Academic Google Scholar Y. Pessach, Y. Pessach Department of Dermatology, Tel Aviv Sourasky Medical Center, ...
Tópico(s): Cancer, Lipids, and Metabolism
2011 - Oxford University Press | Clinical and Experimental Dermatology
Md Fazlur Rahman, Candice C. Askwith, Rajgopal Govindarajan,
... e1000833Crossref PubMed Scopus (145) Google Scholar, 22.Molho-Pessach V. Lerer I. Abeliovich D. Agha Z. Abu ... Scholar, 25.Priya T.P. Philip N. Molho-Pessach V. Busa T. Dalal A. Zlotogorski A. H ... Scopus (17) Google Scholar, 27.Colmenero I. Molho-Pessach V. Torrelo A. Zlotogorski A. Requena L. Emperipolesis: ...
Tópico(s): Drug Transport and Resistance Mechanisms
2017 - Elsevier BV | Journal of Biological Chemistry
... read with great interest the article by Molho-Pessach et al1Molho-Pessach V. Agha Z. Aamar S. Glaser B. Doviner ... the male patients in the article by Molho-Pessach et al.1Molho-Pessach V. Agha Z. Aamar S. Glaser B. Doviner ... Scopus (20) Google Scholar the article by Molho-Pessach et al,1Molho-Pessach V. Agha Z. Aamar S. Glaser B. Doviner ... the reported patients are of Arab descent.1Molho-Pessach V. Agha Z. Aamar S. Glaser B. Doviner ... be associated with other features, such as hepatosplenomegally1Molho-Pessach V. Agha Z. Aamar S. Glaser B. Doviner ...
Tópico(s): Histiocytic Disorders and Treatments
2009 - Elsevier BV | Journal of the American Academy of Dermatology
Javier Chinen, Yousef R. Badran, Raif S. Geha, Janet Chou, Ari J. Fried,
... Text PDF PubMed Google Scholar, 2Brauer P.M. Pessach I.M. Clarke E. Rowe J.H. Ott ... Google Scholar and Brauer et al2Brauer P.M. Pessach I.M. Clarke E. Rowe J.H. Ott ... Google Scholar and Brauer et al2Brauer P.M. Pessach I.M. Clarke E. Rowe J.H. Ott ... reported by Brauer et al.2Brauer P.M. Pessach I.M. Clarke E. Rowe J.H. Ott ...
Tópico(s): Immune Cell Function and Interaction
2017 - Elsevier BV | Journal of Allergy and Clinical Immunology
Stanley M. Besen, Willard G. Manning, Bridger M. Mitchell,
... 53–77.https://doi.org/10.1080/08997760701806850Guy Pessach Israeli Copyright Law: A Positive Economic Perspective, Israel ...
Tópico(s): Merger and Competition Analysis
1978 - University of Chicago Press | The Journal of Law and Economics
... doi.org/10.1080/10168739100080003Leora Rubin Meridor, Shula Pessach The Balance-of-Payments Offset to Monetary Policy: ...
Tópico(s): Financial Markets and Investment Strategies
1974 - University of Chicago Press | Journal of Political Economy
Valentina Broshtilova, Yuval Ramot, Vered Molho‐Pessach, Abraham Zlotogorski,
The H syndrome is a recently reported autosomal recessive disease with variable inter- and intra-familial clinical manifestations. The clinical, histopathological and molecular findings have been described in detail [1–3]. The major clinical findings include cutaneous hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height, hallux valgus and hyperglycaemia/diabetes mellitus. Less common manifestations include facial telangiectasia, proptosis, ...
Tópico(s): Pancreatic function and diabetes
2009 - Wiley | Diabetic Medicine
Itai M. Pessach, Jolán E. Walter, Luigi D. Notarangelo,
Primary immunodeficiencies (PIDs) have traditionally been defined according to their immunologic phenotype. Far from being concluded, the search for human genes that, when mutated, cause PID is actively being pursued. During the last year, four novel genetic defects that cause severe combined immunodeficiency and severe congenital neutropenia have been identified. At the same time, the immunologic definition of primary immunodeficiencies has been expanded by the recognition that genetic defects affecting ...
Tópico(s): Immune Cell Function and Interaction
2009 - Springer Nature | Pediatric Research
Itai M. Pessach, Luigi D. Notarangelo,
Recent studies indicate that genes located on the X-chromosome play a major and unique role in autoimmunity. The fact that most X-linked primary immune deficiencies carry significant autoimmune manifestations greatly supports this notion. Autoimmunity and immune deficiency have been considered two opposite extremes resulting from immune dysregulation and failure of immune development and/or function, respectively. Growing evidence has been accumulating to indicate that autoimmune phenomena occur ...
Tópico(s): T-cell and B-cell Immunology
2009 - Elsevier BV | Journal of Autoimmunity
... org/10.1016/S1574-0730(07)01003-1Guy Pessach Israeli Copyright Law: A Positive Economic Perspective, Israel ...
Tópico(s): Legal principles and applications
1991 - University of Chicago Press | The Journal of Legal Studies
... 389–402.https://doi.org/10.1080/13571510500300611Guy Pessach The Legacy of Feist Revisited – A Critical Analysis ...
Tópico(s): Intellectual Property and Patents
1992 - University of Chicago Press | The Supreme Court Review
... 1111/j.1468-0297.2006.01101.xAnna Rubinchik-Pessach, Roberto M. Samaniego Demand for Contract Enforcement and ...
Tópico(s): Merger and Competition Analysis
1992 - University of Chicago Press | The Journal of Law and Economics
... 10.1111/j.1467-6419.2006.00259.xGuy Pessach Israeli Copyright Law: A Positive Economic Perspective, Israel ...
Tópico(s): Legal principles and applications
1992 - University of Chicago Press | The Journal of Legal Studies
... 10.1111/j.1467-6419.2006.00259.xGuy Pessach Israeli Copyright Law: A Positive Economic Perspective, Israel ...
Tópico(s): Copyright and Intellectual Property
1992 - University of Chicago Press | The Journal of Legal Studies
... neutrophils and granulocytic like PLB-985 cells I. Pessach, R. Levy. 10. Activation of cytosolic phospholipase A2 ...
Tópico(s): Pediatric health and respiratory diseases
2002 - Springer Nature | Advances in experimental medicine and biology
Zeev Shmelzer, Nurit Haddad, Ester Admon, Itai M. Pessach, Thomas L. Leto, Zahit Eitan-Hazan, Michal Hershfinkel, Rachel Lévy,
Cytosolic phospholipase A2 (cPLA2)–generated arachidonic acid (AA) has been shown to be an essential requirement for the activation of NADPH oxidase, in addition to its being the major enzyme involved in the formation of eicosanoid at the nuclear membranes. The mechanism by which cPLA2 regulates NADPH oxidase activity is not known, particularly since the NADPH oxidase complex is localized in the plasma membranes of stimulated cells. The present study is the first to demonstrate that upon stimulation ...
Tópico(s): Receptor Mechanisms and Signaling
2003 - Rockefeller University Press | The Journal of Cell Biology
Vered Molho‐Pessach, Ziad Agha, Suhail Aamar, Benjamin Gläser, Victoria Doviner, Nurith Hiller, David Zangen, Annick Raas‐Rothschild, Ziva Ben‐Neriah, Shaher Shweiki, Orly Elpeleg, Abraham Zlotogorski,
The association of cutaneous hyperpigmented, hypertrichotic, and indurated patches associated with hearing loss, short stature, cardiac anomalies, hepatosplenomegaly, scrotal masses, and hypogonadism has not, to our knowledge, been previously recognized as a disease entity.We describe 10 patients with the above-mentioned findings.Patients were clinically examined and extensive laboratory evaluation was performed.We describe 10 patients from 6 Arab consanguineous families with hyperpigmented, hypertrichotic, ...
Tópico(s): Genetic and Kidney Cyst Diseases
2008 - Elsevier BV | Journal of the American Academy of Dermatology
Memory institutions are social entities that select, document, contextualize, preserve, index and thus canonize elements of humanity's culture, historical narratives, individual and collective memories. Archives, museums and libraries are paradigmatic examples for traditional memory institutions. Content-sharing platforms, social networks, peer-to-peer file-sharing infrastructures, digital images agencies, online music stores and search engines' utilities represent emerging novel entities with a ...
Tópico(s): Digital Rights Management and Security
2008 - RELX Group (Netherlands) | SSRN Electronic Journal
Vered Molho‐Pessach, Israela Lerer, Dvorah Abeliovich, Ziad Agha, Abdulasalam Abu Libdeh, Valentina Broshtilova, Orly Elpeleg, Abraham Zlotogorski,
The H syndrome is a recently reported autosomal-recessive disorder characterized by cutaneous hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, short stature, hallux valgus, and fixed flexion contractures of the toe joints and the proximal interphalangeal joints. Homozygosity mapping in five consanguineous families resulted in the identification of mutations in the SLC29A3 gene, which encodes the equilibrative nucleoside transporter hENT3. Three ...
Tópico(s): Amino Acid Enzymes and Metabolism
2008 - Elsevier BV | The American Journal of Human Genetics
Luigi D. Notarangelo, Itai M. Pessach,
Pulmonary alveolar proteinosis (PAP) is a rare disorder in which surfactant homeostasis in the lung is impaired, causing respiratory distress and, in severe cases, respiratory failure. Most cases of PAP are associated with the formation of autoantibodies against the cytokine granulocyte/macrophage colony-stimulating factor (GM-CSF), which is required for normal surfactant homeostasis and lung function. New studies now identify three patients in whom PAP was caused by mutations in the gene encoding ...
Tópico(s): Respiratory Support and Mechanisms
2008 - Rockefeller University Press | The Journal of Experimental Medicine
Orit Karnieli‐Miller, Roni Strier, Liat Pessach,
This article focuses on the tensions between the commitment to power redistribution of the qualitative paradigm and the ethical and methodological complexity inherent in clinical research. Qualitative inquiry, in general, though there are significant variations between its different paradigms and traditions, proposes to reduce power differences and encourages disclosure and authenticity between researchers and participants. It clearly departs from the traditional conception of quantitative research, ...
Tópico(s): Participatory Visual Research Methods
2008 - SAGE Publishing | Qualitative Health Research
Victoria Doviner, Alexander Maly, Zvi Neʼeman, Rami Qawasmi, Suhail Aamar, Mutaz Sultan, Maya Spiegel, Vered Molho‐Pessach, Abraham Zlotogorski,
This study analyzes the histopathological findings in H syndrome, a recently recognized autosomal recessive genodermatosis characterized by indurated, hyperpigmented, and hypertrichotic skin in well-defined anatomical areas accompanied by various systemic manifestations. So far, descriptions of the histopathological skin changes in this disorder, as reported in a few small case series, were inconsistent, leading to diverse clinical interpretations. In an attempt to define standardized, diagnostic, ...
Tópico(s): Skin and Cellular Biology Research
2010 - Lippincott Williams & Wilkins | American Journal of Dermatopathology
Tannu Priya, N. Philip, Vered Molho‐Pessach, Tiffany Busa, Ashwin Dalal, Abraham Zlotogorski,
The H syndrome (OMIM 612391) is a recently described autosomal recessive disorder characterized by cutaneous hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, short stature (low height), hyperglycaemia/diabetes mellitus, hallux valgus, and fixed flexion contractures of the toe and finger joints.1, 2 Histologically, there is an inflammatory infiltrate consisting mainly of histiocytes, later replaced by fibrosis of the deep dermis and subcutis.3 In total, ...
Tópico(s): Ubiquitin and proteasome pathways
2010 - Oxford University Press | British Journal of Dermatology
Itai M. Pessach, José Ordovás-Montañés, Shen‐Ying Zhang, Jean‐Laurent Casanova, Silvia Giliani, Andrew R. Gennery, Waleed Al‐Herz, Philip D. Manos, Thorsten M. Schlaeger, In‐Hyun Park, Francesca Rucci, Suneet Agarwal, Gustavo Mostoslavsky, George Q. Daley, Luigi D. Notarangelo,
BackgroundThe novel ability to epigenetically reprogram somatic cells into induced pluripotent stem cells (iPSCs) through the exogenous expression of transcription promises to revolutionize the study of human diseases.ObjectiveHere we report on the generation of 25 iPSC lines from 6 patients with various forms of primary immunodeficiencies (PIDs) affecting adaptive immunity, innate immunity, or both.MethodsPatients' dermal fibroblasts were reprogrammed by expression of 4 transcription factors, octamer- ...
Tópico(s): Renal and related cancers
2010 - Elsevier BV | Journal of Allergy and Clinical Immunology
Jolán E. Walter, Francesca Rucci, Laura Patrizi, Mike Recher, Stephan Regenass, Tiziana Paganini, Márton Keszei, Itai M. Pessach, Philipp A. Lang, Pietro Luigi Poliani, Silvia Giliani, Waleed Al‐Herz, Morton J. Cowan, Jennifer M. Puck, Jack Bleesing, Tim Niehues, Catharina Schuetz, Harry L. Malech, Suk See De Ravin, Fabio Facchetti, Andrew R. Gennery, Emma Andersson, Naynesh Kamani, JoAnn Sekiguchi, Hamid M. Alenezi, Javier Chinen, Ghassan Dbaibo, Gehad ElGhazali, A. Fontana, Srdjan Pašić, Cynthia Detre, Cox Terhorst, Frederick W. Alt, Luigi D. Notarangelo,
The contribution of B cells to the pathology of Omenn syndrome and leaky severe combined immunodeficiency (SCID) has not been previously investigated. We have studied a mut/mut mouse model of leaky SCID with a homozygous Rag1 S723C mutation that impairs, but does not abrogate, V(D)J recombination activity. In spite of a severe block at the pro–B cell stage and profound B cell lymphopenia, significant serum levels of immunoglobulin (Ig) G, IgM, IgA, and IgE and a high proportion of Ig-secreting cells ...
Tópico(s): Immune Cell Function and Interaction
2010 - Rockefeller University Press | The Journal of Experimental Medicine
Vered Molho‐Pessach, Ruth Bargal, Yigal Abramowitz, Victoria Doviner, Arieh Ingber, Annick Raas‐Rothschild, Zvi Neʼeman, Marsha Zeigler, Abraham Zlotogorski,
Background Human β-mannosidosis, a rare disorder of oligosaccharide catabolism, results from a deficiency of β-mannosidase activity. So far, mutational analysis has been performed in only seven families and revealed 11 mutations in the MANBA gene which encodes the enzyme β-mannosidase. Objectives We report here a 36-year-old Arab female with β-mannosidosis who presented with mental retardation and multiple angiokeratomas. We describe in this patient a novel null mutation and review the previously ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2007 - Elsevier BV | Journal of the American Academy of Dermatology
Daphna Shefet, Hagit Dascal‐Weichhendler, Orit Rubin, Nirit Pessach, Dvora Itzik, Shuli Benita, Amitai Ziv,
Background: Although physicians are in a unique position to identify and report domestic violence (DV), detection rates are poor.Aim: To develop a national DV experiential training program, based on standardized patients (SPs), to improve knowledge, skills and detection rates among physicians.Methods: The program was initiated by the Israeli Ministry of Health and took place at the Israel Center of Medical Simulation (MSR). Three one-day workshops for physicians were developed, each focusing on intimate ...
Tópico(s): Trauma and Emergency Care Studies
2007 - Taylor & Francis | Medical Teacher