Dragica Zendelovska, Trajče Stafilov, Petar Miloševski,
A high-performance liquid chromatographic method was developed, validated and applied for the determination of hydrochlorothiazide in human plasma. The effects of mobile phase composition, buffer concentration, mobile phase pH and concentration of organic modifiers on retention of hydrochlorothiazide and internal standard were investigated. The method involves solid-phase extraction on RP-select B cartridges followed by isocratic reversed-phase chromatography on a Hibar Lichrospher 100 RP-8 column ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2004 - Wiley | Biomedical Chromatography
Irena Kafeđiska, Dejan Spasovski, Todor Gruev, M Grlickov, K Čakalaroski, Vlado Serafimovski, Tatjana Sotirova, Petar Miloševski,
Association Between Osteoarticular Scores and Acute Phase Reactant Levels in Rheumatoid Arthritis The aim of this prospective control study was a quantitative evaluation of the activity of rheumatoid arthritis (RA) in certain time intervals, using articular indexes (set of 28 sensitive and 28 swollen joints), laboratory parameters (Hb, Hct, Er, Le and Plt) and acute phase reactants (ESR, RF, CRP); to determine which of the acute phase reactants is the most useful biochemical marker for the evaluation ...
Tópico(s): Spondyloarthritis Studies and Treatments
2009 - De Gruyter | Journal of Medical Biochemistry
Dimče Zafirov, Jasmina Trojačanec, Maja Slaninka-Miceska, Krume Jakovski, Dragica Zendelovska, Valentina Kolovska, Petar Miloševski, Stojmir Petrov,
Amifostine is a relatively new organic cytoprotective drug that is actually a prodrug aimed at reduction of cumulative renal toxicity induced by cisplatin repeated administration. The mechanism of amifostin nephroprotective effects has still not been clarified, but it is considered that this medicine has direct cytoprotective effect on kidney tubuli. The main aim of this study was to reveal the effect of amifostin in prevention of nephrotoxicity induced experimentally with long-term administration ...
Tópico(s): Lanthanide and Transition Metal Complexes
2006 - University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association | Macedonian Pharmaceutical Bulletin