... Worsaae. One of the other protagonists, the Norwegian Peter Andreas Munch, was probably responsible for introducing the concept to ...
2006 - Cambridge University Press | European Journal of Archaeology
G.J. Krausse, Peter Andreas Munch Gram,
We describe a monitor, based on a multiwire proportional chamber, that displays with mm resolution the profiles of secondary particle beams ranging in intensity from 105/cm2-s to 1010/cm2-s. The display, which appears on a standard oscilloscope, is live and quantitative; the effect of adjustments of the beam transport is immediately and continuously visible.
Tópico(s): Particle Detector Development and Performance
1978 - Elsevier BV | Nuclear Instruments and Methods
Götz Münch, Andreas Bültmann, Zhongmin Li, Hans‐Peter Holthoff, Julia Ullrich, Silvia Wagner, Martin Ungerer,
The ABCG1 protein is centrally involved in reverse cholesterol transport from the vessel wall. Investigation of the effects of ABCG1 overexpression or knockdown in vivo has produced controversial results and strongly depended on the gene intervention model in which it was studied. Therefore, we investigated the effect of local overexpression of human ABCG1 in a novel model of vessel wall-directed adenoviral gene transfer in atherosclerotic rabbits. We conducted local, vascular-specific gene transfer ...
Tópico(s): Cancer, Lipids, and Metabolism
2012 - Wichtig | Heart International
Stephan Reitzenstein, A. V. Bazhenov̇, А. В. Горбунов, C. Hofmann, S. Münch, Andreas Löffler, M. Kamp, Johann Peter Reithmaier, V. D. Kulakovskiĭ, A. Forchel,
We present lasing in optically pumped high-Q micropillar cavity lasers with low thresholds and high β factors. The micropillar cavities with diameters between 1.0 and 4.0μm contain a single layer of low density In0.3Ga0.7As quantum dots as active region. Cavity Q factors of up to 23.000 for 4.0μm micropillar cavities and lasing based on less than 70 quantum dots is demonstrated.
Tópico(s): Semiconductor Lasers and Optical Devices
2006 - American Institute of Physics | Applied Physics Letters
Detlef K. Bartsch, I. Kopp, Anders Bergenfelz, Harald Rieder, Karin Münch, Karin Jäger, Yvonne Deiss, Andreas Schudy, Peter Barth, Roland Arnold, Μ. Rothmund, Babette Simon,
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited tumor syndrome characterized by the development of multiple endocrine tumors. The gene responsible for the disease, termed MEN1 gene. has recently been isolated and germline mutations have been described in affected MEN1 individuals. Twelve unrelated (German MEN1 families and their associated tumors (5 parathyroid tumors, 1 vipoma, 1 gastrinoma, 1 insulinoma) were characterized for MEN1 gene mutations by single-strand conformational ...
Tópico(s): Gestational Trophoblastic Disease Studies
1998 - Oxford University Press | European Journal of Endocrinology
Niels Vidiendal Olsen, Niels‐Jacob Aachmann‐Andersen, Peter Oturai, Thor Munch‐Andersen, Andreas Bornø, Carl J. Hulston, Niels‐Henrik Holstein‐Rathlou, Paul Robach, Carsten Lundby,
Non‐technical summary Recombinant human erythropoietin (rHuEPO) decreases circulating levels of renin and aldosterone, two hormones regulating water and salt homeostasis, but the effect of rHuEPO on renal function is unknown. This study demonstrates that rHuEPO reduces the reabsorption of water and sodium in the proximal renal tubules and, probably by activation of the tubuloglomerular feedback mechanism, also causes a fall in glomerular filtration rate. Thus, the decrease in plasma concentrations ...
Tópico(s): Acute Kidney Injury Research
2010 - Wiley | The Journal of Physiology
Götz Münch, Andreas Raether, Ernst Schöffel, Péter Illés,
Changes in the external diameter of rabbit isolated jejunal arteries were measured by a photoelectric device. Both norepinephrine and dopamine produced vasoconstriction; prazosin, but not idazoxan, antagonized these effects. Arteries preconstricted with norepinephrine were dilated by SKF 38393 and LY 171555. SCH 23390 antagonized both compounds, however, in the case of LY 171555 with a lower potency. Sulpiride also interacted with LY 171555. When arteries were preconstricted with PGF2α in the presence ...
Tópico(s): Receptor Mechanisms and Signaling
1991 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Christian Holwein, Stefan Hinterwimmer, Herrmann O. Mayr, Lena Lämmle, Peter U. Brucker, Ernst-Otto Münch, Andreas B. Imhoff,
This study evaluates sports ability, rotational laxity and potential growth changes in children after transphyseal ACL reconstruction with metaphyseal fixation technique, considering physis biology by placing drill holes vertically in the femoral anatomic origin in order to reduce volumetric injury to the physis.In this retrospective trial of 42 patients data were collected. Thirty-seven were reviewed measuring rotational laxity and anteroposterior tibial translation using the Laxitester (ORTEMA ...
Tópico(s): Shoulder Injury and Treatment
2016 - Elsevier BV | The Knee
Hanna Renk, Alex Dulovic, Alina Seidel, Matthias Becker, Dorit Fabricius, Maria Zernickel, Daniel Junker, Rüdiger Groß, Janis A. Müller, Alexander Hilger, Sebastian F. N. Bode, Linus Fritsch, Pauline Frieh, Anneke Haddad, Tessa Görne, Jonathan Remppis, Tina Ganzemueller, Andrea Dietz, Daniela Huzly, Hartmut Hengel, Klaus Kaier, Susanne Weber, Eva‐Maria Jacobsen, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Maximilian Stich, Burkhard Tönshoff, Georg F. Hoffmann, Bárbara Müller, Carolin Ludwig, Bernd Jahrsdörfer, Hubert Schrezenmeier, Andreas Peter, Sebastian Hörber, Thomas Iftner, Jan Münch, Thomas Stamminger, Hans‐Jürgen Groß, Martin Wolkewitz, Corinna Engel, Weimin Liu, Marta Rizzi, Beatrice H. Hahn, Philipp Henneke, Axel R. Franz, Klaus‐Michael Debatin, Nicole Schneiderhan‐Marra, Aleš Janda, Roland Elling,
The quality and persistence of children's humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. We assess serological response at 3-4 months and 11-12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens including ...
Tópico(s): COVID-19 epidemiological studies
2022 - Nature Portfolio | Nature Communications
Andreas Marc Palmer, Gabriela Münch, Christof Brehm, Peter Jan Zimmermann, Wilm Buhr, Martin P. Feth, Wolfgang Simon,
A series of novel 1H-pyrrolo[3,2-b]pyridines was prepared relying on a copper iodide catalyzed cyclization of 2-prop-1-ynylpyridin-3-amines. A structure-activity relationship was established focusing on the influence of the substitution pattern in position 1, 3, and 5 of the heterocycle on anti-secretory activity, lipophilicity, and pK(a) value. Some of the compounds proved to be potent inhibitors of the gastric acid pump.
Tópico(s): Asymmetric Synthesis and Catalysis
2007 - Elsevier BV | Bioorganic & Medicinal Chemistry
J. Larsson, Konstantinos J. Dabos, Peter Höglund, Johan Bohr, Andreas Münch, Andry Giannakou, Artúr Németh, Gabriele Wurm-Johansson, Ervin Tóth, John Plevris, Paul Fineron, Anastasios Koulaouzidis, Klas Sjöberg,
Data on malignancy in patients with collagenous colitis (CC) is scarce. We aimed to determine the incidence of cancers in patients with CC. In a two-stages, observational study, data on cancers in patients diagnosed with CC during 2000-2015, were collected from two cohorts. The risk was calculated according to the age-standardized rate for the first cohort and according to the standardized incidence ratio for the second cohort. The first cohort comprised 738 patients (394 from Scotland and 344 from ...
Tópico(s): Inflammatory Bowel Disease
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Christa Strasser, E Wolf, Peter Kornprat, J Hermann, Andreas Münch, Cord Langner,
We present the case of a 58-year-old woman with a long-standing history of systemic lupus erythematosus (SLE) who developed a cytomegalovirus (CMV) infection with colonic perforation and subsequent purulent peritonitis whilst using combined immunosuppressive therapy. The pathogenesis and the clinical presentation of this unique case is discussed in detail. Opportunistic infection should always be kept in mind in SLE patients presenting with fever. Viral serology should be routinely performed in these ...
Tópico(s): Mycobacterium research and diagnosis
2011 - SAGE Publishing | Lupus
Andreas Marc Palmer, Sandra Chrismann, Gabriela Münch, Christof Brehm, Peter Jan Zimmermann, Wilm Buhr, Jörg Senn‐Bilfinger, Martin P. Feth, Wolfgang Simon,
Asymmetric and symmetric spiro(imidazo[1,2-a]pyrano[2,3-c]pyridine-9-indenes) were prepared using a synthetic approach that comprised a cross-metathesis reaction and an acid-catalyzed cycloisomerisation as key steps. The target compounds constitute potent inhibitors of the gastric proton pump enzyme with inhibitory activity comparable to potassium-competitive acid blockers (P-CABs) belonging to the known 9-aryl-7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a]pyridine series. Spiro(imidazo[1,2-a]pyrano[2, ...
Tópico(s): Chemical Synthesis and Analysis
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry
Stephan Miehlke, Daniela E. Aust, Emese Mihály, Peter Armerding, G. Böhm, Ole K. Bonderup, Fernando Fernández‐Bañares, Juozas Kupčinskas, Lars Kristian Munck, Kai-Uwe Rehbehn, Tanju Nacak, Roland Greinwald, Andreas Münch, Jiri Stehlk, Ole K. Bonderup, Lars Kristian Munck, T. Rannem, Peter Armerding, Michael Bläker, Günter Böhm, M Hoesl, Christian Kirsch, Ahmed Madisch, Eberhard Meier, Stephan Miehlke, Kai-Uwe Rehbehn, G Kiss, Ferenc Nagy, Zsolt Tulassay, F Zsigmond, Limas Kupčinskas, Gerd Bouma, Marieke Pierik, Fernando Fernández‐Bañares, Alfredo J. Lucendo, Johan Bohr, Per M. Hellström, Barbro Lebrun, Greger Lindberg, Andreas Münch, Lina Vigren, M Wielondek, Martin Krauß, Axel Dignaß, Wolfgang Kruis,
Lymphocytic colitis is a common cause of chronic, nonbloody diarrhea. However, the effects of treatment are unclear and randomized placebo-controlled trials were requested in a Cochrane review. We performed a randomized, placebo-controlled, multicenter study to evaluate budesonide and mesalazine as induction therapy for lymphocytic colitis.Patients with active lymphocytic colitis were randomly assigned to groups given budesonide 9 mg once daily (Budenofalk granules), mesalazine 3 g once daily (Salofalk ...
Tópico(s): Celiac Disease Research and Management
2018 - Elsevier BV | Gastroenterology
Tópico(s): German Literature and Culture Studies
2012 - Norwegian Medical Association | Tidsskrift for Den norske legeforening
Martin Ungerer, Kai Rosport, Andreas Bültmann, Richard Piechatzek, Kerstin Uhland, Peter Schlieper, Meinrad Gawaz, Götz Münch,
Blocking of glycoprotein VI-dependent pathways by interfering in vascular collagen sites is commonly seen as an attractive target for an antiplatelet therapy of acute atherosclerotic diseases such as myocardial infarction or stroke. Revacept (soluble dimeric glycoprotein VI-Fc fusion protein) has been shown to reduce platelet adhesion by blocking vascular collagen in plaques or erosion and to be safe in preclinical studies. A dose-escalating clinical phase I study was performed to assess the safety, ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2011 - Lippincott Williams & Wilkins | Circulation
Andreas Marc Palmer, Vittoria Chiesa, Anja Schmid, Gabriela Münch, Burkhard Grobbel, Peter Jan Zimmermann, Christof Brehm, Wilm Buhr, Wolfgang‐Alexander Simon, W. Krömer, Stefan Postius, Jürgen Volz, Dietmar Hess,
Potassium-competitive acid blockers (P-CABs) constitute a new therapeutic option for the treatment of acid-related diseases that are widespread and constitute a significant economical burden. Enantiomerically pure tetrahydrochromenoimidazoles were prepared using the readily available candidate 4 (BYK 405879) as starting material or the Noyori asymmetric reduction of ketones as key reaction. A comprehensive SAR regarding the influence of the 5-carboxamide and the 8-aryl residue on in vitro activity, ...
Tópico(s): Ion channel regulation and function
2010 - American Chemical Society | Journal of Medicinal Chemistry
Peter Seizer, Oliver Borst, Harald Langer, Andreas Bültmann, Götz Münch, Yared Herouy, Konstantinos Stellos, Björn Krämer, Boris Bigalke, Berthold Büchele, Max G. Bachem, Dietmar Vestweber, Thomas Simmet, Meinrad Gawaz, Andreas E. May,
Summary The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147, basigin) is an immunoglobulin-like receptor expressed in various cell types. During cellular interactions homotypic EMMPRIN-EMMPRIN interactions are known to induce the synthesis of matrix metalloproteinases. Recently, we have identified EMMPRIN as a novel receptor on platelets. To our knowledge EMMPRIN has not been shown to serve as adhesion receptor, yet. Here we characterise platelet glycoprotein VI (GPVI) as a novel adhesion ...
Tópico(s): Signaling Pathways in Disease
2009 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Moritz Mahling, Alexander Münch, Sebastian Schenk, Stephan Volkert, Andreas Rein, Uwe Teichner, Pascal Piontek, Leopold Haffner, Daniel Heine, Andreas Manger, Jörg Reutershan, Peter Rosenberger, Anne Herrmann‐Werner, Stephan Zipfel, C Nora,
Abstract Background Resuscitation is a life-saving measure usually instructed in simulation sessions. Small-group teaching is effective. However, feasible group sizes for resuscitation classes are unknown. We investigated the impact of different group sizes on the outcome of resuscitation training. Methods Medical students (n = 74) were randomized to courses with three, five or eight participants per tutor. The course duration was adjusted according to the group size, so that there was a time slot ...
Tópico(s): Emergency and Acute Care Studies
2014 - BioMed Central | BMC Medical Education
D. Wiedenmann, Lukas M. Keller, Lorenz Holzer, Jelena Stojadinović, Beat Münch, Laura Suárez, Benjamin Fumey, Harald Hagendorfer, Rolf Brönnimann, Peter Modregger, Michal Gorbár, Ulrich Vogt, Andreas Züttel, Fabio La Mantia, Roger Wepf, Bernard Grobéty,
The ion conductivity of two series of porous ceramic diaphragms impregnated with caustic potash was investigated by electrochemical impedance spectroscopy. To understand the impact of the pore structure on ion conductivity, the three‐dimensional (3‐D) pore geometry of the diaphragms was characterized with synchrotron x‐ray absorption tomography. Ion migration was calculated based on an extended pore structure model, which includes the electrolyte conductivity and geometric pore parameters, for example, ...
Tópico(s): Groundwater flow and contamination studies
2013 - Wiley | AIChE Journal
Andreas Reimann, Zhongmin Li, Silvia Goebel, Julia Faßbender, Hans‐Peter Holthoff, Meinrad Gawaz, Götz Münch, Martin Ungerer,
Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) remains the only approved medication for acute ischemic stroke, but incurs significant bleeding risks. Therefore, approaches to combine lower doses of thrombolytic therapy with other effective drugs aim at improving efficacy and reducing bleeding rates. We examined the safety and therapeutic effects of various dosings of rtPA, either alone or combined with glycoprotein VI-Fc fusion protein (GPVI-Fc, Revacept) on experimental ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2016 - Wichtig | Heart International
Hans‐Peter Holthoff, Zhongmin Li, Julia Faßbender, Andreas Reimann, Kristin Adler, Götz Münch, Martin Ungerer,
A model for human Graves disease in mice was used to compare several treatment approaches. The mice received regular adenovirus (Ad) thyroid-stimulating hormone receptor (TSHR) A subunit immunizations (injections every 4 weeks). The generation of anti-TSHR antibodies, enlarged thyroid sizes (goiter), elevated serum thyroxine levels, retro-orbital fibrosis, and cardiac involvement (tachycardia and hypertrophy) were consistently observed over 9 months. Treatment of established disease in these mice using ...
Tópico(s): Thyroid Disorders and Treatments
2017 - Oxford University Press | Endocrinology
Markus Notter, Andreas Thomsen, Mirko Nitsche, Robert Michael Hermann, Hendrik A. Wolff, Gregor Habl, Karin Münch, Anca‐L. Grosu, Peter Vaupel,
Effective tumor control in patients suffering from unresectable locally recurrent breast cancer (LRBC) in pre-irradiated areas can be achieved by re-irradiation combined with superficial hyperthermia. Using this combined modality, total re-irradiation dose and toxicity can be significantly reduced compared to conventionally fractionated treatment schedules with total doses of 60–66 Gy. Applying contact-free, thermography-controlled water-filtered infrared-A superficial hyperthermia, immediately followed ...
Tópico(s): Microbial Inactivation Methods
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Marcel Reiser, R. Schnell, Gilles Straub, Peter Borchmann, Mathias Wilhelm, Ralf Übelacker, B. Wörmann, R Münch, Volker Diehl, Andreas Engert,
We performed a phase II study of dexamethasone, ifosfamide, idarubicin and etoposide (DIZE) in patients with relapsed or refractory Hodgkin's (HL) and non-Hodgkin's lymphoma (NHL). The regimen consisted of dexamethasone (20 mg i.v. days 1-4), idarubicin (8 mg/m2 i.v. days 1+2), continuous infusion (c.i.) of ifosfamide (1,000 mg/m2 days 1-4), and c.i. etoposide (60 mg/m2 days 1-4). G-CSF (5 µ g/kg) was used to support neutrophil recovery from day 5. In older patients (> 60 years) the dosage of idarubicin and ...
Tópico(s): Acute Lymphoblastic Leukemia research
1998 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Thomas Morville, Mads Rosenkilde, Thor Munch‐Andersen, Peter Riis Andersen, KATJA KJÆR GROENBÆK, Signe Helbo, M. Kristensen, Andreas Vigelsø, Nick Mattsson, Hanne Rasmusen, Amelia Guadalupe‐Grau, Angela Fago, Christina Hansen, Brigitte Twelkmeyer, Jesper L. Andersen, Flemming Dela, Jørn Wulff Helge,
Fat metabolism and muscle adaptation was investigated in six older trained men (age, 61 ± 4 yr; V˙O2max, 48 ± 2 mL·kg·min) after repeated prolonged exercise).A distance of 2706 km (1681 miles) cycling was performed over 14 d, and a blood sample and a muscle biopsy were obtained at rest after an overnight fast before and 30 h after the completion of the cycling. V˙O2max and maximal fat oxidation were measured using incremental exercise tests. HR was continuously sampled during cycling to estimate exercise ...
Tópico(s): Adipose Tissue and Metabolism
2016 - Lippincott Williams & Wilkins | Medicine & Science in Sports & Exercise
Stephan Zeibig, Zhongmin Li, Silvia Wagner, Hans‐Peter Holthoff, Martin Ungerer, Andreas Bültmann, Kerstin Uhland, Jasmin Vogelmann, Thomas Simmet, Meinrad Gawaz, Götz Münch,
Rationale: There is strong evidence that oxidative modification of low-density lipoprotein (oxLDL) plays a critical role in atherogenesis and that oxLDL may profoundly influence the mechanical stability of atherosclerotic plaques. Objective: To block oxLDL, we designed, expressed, and tested Fc-CD68, a soluble oxLDL binding protein consisting of human Fc and the extracellular domain of the human oxLDL-binding receptor CD68. Methods and Results: Fc-CD68 bound with high specific affinity to oxLDL and ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2011 - Lippincott Williams & Wilkins | Circulation Research
Karin Daub, Dorothea Siegel‐Axel, Tanja Schönberger, Christoph Leder, Peter Seizer, Karin Müller, Martin Schaller, Sandra Penz, Dagmar Menzel, Berthold Büchele, Andreas Bültmann, Götz Münch, Stephan Lindemann, Thomas Simmet, Meinrad Gawaz,
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2010 - Springer Science+Business Media | Journal of Molecular Medicine
Andreas Münch, Johan Bohr, Stephan Miehlke, Cecilia Benoni, Martin Olesen, Åke Öst, Lars Strandberg, Per M. Hellström, Erik Hertervig, Peter Armerding, Jiřı́ Stehlı́k, Greger Lindberg, Jan Björk, Annika Lapidus, Robert Löfberg, Ole K. Bonderup, Søren Avnstrøm, Martin Rössle, Karin Dilger, Ralph Müeller, Roland Greinwald, Curt Tysk, Magnus Ström,
Objective This 1-year study aimed to assess low-dose budesonide therapy for maintenance of clinical remission in patients with collagenous colitis. Design A prospective, randomised, placebo-controlled study beginning with an 8-week open-label induction phase in which patients with histologically confirmed active collagenous colitis received budesonide (Budenofalk, 9 mg/day initially, tapered to 4.5 mg/day), after which 92 patients in clinical remission were randomised to budesonide (mean dose 4.5 mg/day; Budenofalk ...
Tópico(s): Potassium and Related Disorders
2014 - BMJ | Gut
... writings of Viktor Rydberg in Sweden and of Peter Andreas Munch in Norway reflect this nineteenth-century concern with ...
Tópico(s): Cultural Studies and Interdisciplinary Research
1969 - Western Michigan University | Comparative drama
A note from Professor Peter Andreas Munch, an Honorary Member of the Society, that was read out loud at the meeting on December 8, 1851. It describes ...
Tópico(s): Geology and Paleoclimatology Research
1852 - Society of Antiquaries of Scotland | Proceedings of the Society of Antiquaries of Scotland