Giles Smith, Andrew Robson, Oliver Hyams, Carol Lewis, Taking Flak, Robert Cole, Andrew Pierce, DJM, David Brown, Sarah Potter, Gary Duncan, Patrick Muirhead, Alexandra Blair, Robert Thicknesse, Keith R. Mitchell, Christopher Wood, June Bell, Adam Luck, Mark Souster, Richard Hobson, David Rose, Ivo Tennant, Andrew Robinson, Simon Cambers, Philip Howard, Camilla Cavendish, Christine Seib, Ruth Gledhill and Jonathan Wynne-Jones, David Chater, Rachel Campbell-Johnston, James Ducker, Nic Hopkins, Patrick Kidd, Nat Segnit, Sam Marlowe, Wendy Ide, Roger Maynard, Geoff Brown, Ben Webster Transport Correspondent, Pat Gibson, Jane MacArtney, Catherine Philp and Ali Hussain, Tom Bawden, Steve Bird, Ruth Gledhill, James Doran Wall Street Correspondent, Dominic Walsh, Debra Craine, Jill Dupleix, Toby Moore, Angela Jameson Industrial Correspondent, Dan Sabbagh, Ainsley Newson, Alan Hamilton, Stephen Farrell, Anatole Kaletsky, David Charter Chief Political Correspondent and Michael Evans, Phil Gordon, Charles Bremner, Joanne Lunn, Graham Keeley, Ian MacKinnon, Ron Lewis, Helen Rumbelow, Matt Dickinson Chief Football Correspondent, Liz Chong, Bronwen Maddox Foreign Editor's Briefing, William Shawcross, Daniel Murdoch, Angela Jameson, Kevin Bakhurst, Marcel Berenblut, Paula Hawkins, Tom Wainwright, Tony Halpin Education Editor, Daniel McGrory, Gary Duncan Economics Editor, Oliver Kay, John Woodcock, Colin MacKay, Tom Baldwin, Mark Henderson Science Correspondent, Stewart Tendler and Richard Ford, Rob Wright, Geoffrey Dean, Gabriel Rozenberg, David Powell Athletics Correspondent, Dan Murphy, Raymond Keene, Simon Freeman, Lewis Smith, Matthew Pryor, Sean MacAulay, Rebecca O'Connor, Hilary Synnott (Director for South and South-East Asia), Martin Patience, Neville Scott, Cathy Harris, Richard Owen, Peter Dixon, Nick Hasell, Carolyn Asome, David Hands Rugby Correspondent, Kevin Maher, Siân Morgan, Paul Simons, Peter Dobson, Michelle Henery, Nick Szczepanik, Rachel Ragg, Jane Bidder, Mary Ann Sieghart, Ian Johns, Dominic Maxwell, Ashling O'connor, Frank Greaney, Bruce Anderson, Richard Beeston Diplomatic Editor and Zahid Hussein, George Caulkin, Esther Walker, Alan Lee, Stephen Hoare, Tony Dawe, Ben Webster, Carly Chynoweth, Jack Malvern Arts Reporter, Michael Horsnell, Chris Ayres, Michael W. Stone, Nigel Hawkes Health Editor, Benedict Nightingale, Angus Batey, Dr Thomas Stuttaford, Stephen Dalton, Leo Lewis, Cherry Potter, Bill Edgar, Richard Morrison, Lucy Tobin, Tony Halpin, Alexandra Blair Education Correspondent, Olav Bjortomt, Patience Wheatcroft, Raekha Prasad, Damian Barr, Allan Wilson,
... Nature Notes On this Day August 18, 1962 Peter Fechter, a young East German, was one of 192 ...
2005 - Gale Group | TDA
Laurence D. Fechter, Peter R. Thorne, Alfred L. Nuttall,
The belief that the cochlea is particularly vulnerable to a reduction in oxygen availability comes predominantly from studies reporting the disruption of electrophysiological measures, such as the compound action potential, endocochlear potential, inner hair cell intracellular potentials or afferent nerve fiber responses by asphyxiation. Because hypoxia has frequently been suggested as an underlying mechanism by which many ototoxic agents produce injury, and because such agents are not likely to ...
Tópico(s): Neuroscience of respiration and sleep
1987 - Elsevier BV | Hearing Research
Ernest Newman, G. G. O., F. C. Pearce, F. Willis, E. N., N. W. Chronic, Gilbert Dalziel, Sir John Marriott M. P., Yarborough, Percy Bono, M. J., Ralph Straus, James Strong, H. H. Berton, Herbert Sidebotham, Professor W. Caldwell, J. M. Bulloch, E. Thring, Sir Arthur Conan Doyle, F. H. Evans, E. V. Lucas, A Patient Taxpayer, E. A. T., Edgar Syers, James Agate, Frank Rutter, L. S. Powell, Frederic Winder, the Rt. Hon. T. P. O'connor M. P., Louis E. Stevenson, Mauser, M. B. Arnold, Erroll Sherson, Vigilant, H. S. Rogers, Morris Hudson, George C. Stead, D. R. Gent, G. H. Smith, H. C. Minchin, James Seton-Anderson, W. Herbert A. Smith M. D., A. L. Cox, Brodie Fraser, Wickham Steed, Dilys Powell, Hugh M. Baker, M. Hoyland, Commander A. T. Stewart R. N., M. Paterson, John D. Hamilton, Prebendary A. W. Gough, Harold M. Abrahams, Hugh Maonaghten, A. F. Blood, L. Van-Vliet, R. J. Barrett Financial Editor, John H. Burton, Harold Cox,
... Patient Taxpayer: Mental Defectives "Up to the Mark" Fechter's Origins Fruit in France The History of ... s Own House Mediterranean Dickins & Jones The Bystander Peter Robinson, Ltd. Treloar for Carpets From our Own ...
1926 - Gale Group | Sunday Times HA GDA
Eric J. Fechter, Peter B. Dervan,
The sequence-specific inhibition of essential protein-DNA contacts in the promoter of a gene is a central issue for the regulation of gene expression by chemical methods. Hairpin polyamides have been shown to inhibit protein-DNA complexes in some but not all cases. For example, polyamides co-occupy the same DNA sequence in the minor groove in the presence of major-groove binding bZip proteins. Four hairpin polyamide-acridine conjugates were synthesized and shown to bind the minor groove of DNA with ...
Tópico(s): RNA and protein synthesis mechanisms
2003 - American Chemical Society | Journal of the American Chemical Society
Ernest Newman, Jose Tauler, A. A. Campbell Swinton, Sir John Bland-Sutton, H. G., R. H. Thomas, Mailand Davidson, John McKerrow, (Mrs.) G. H. Browett, Watson Lyle, U. F., Yarborough, L. E. Whittington, Capt. Anthony Eden M. P., Roland Atkinson ("Sunday Times" Paris Correspondent), Jack Edwards, J. M. Bulloch, M. A. Macnamara, E. V. Lucas, V. E. H., the Rt. Hon. T. P. O'connor M. P., James Agate, Frank Rutter, E. E. Oa., Vigilant, Philip Gosse, Anthony Somers, Sydney W. Carroll, George C. Stead, D. R. Gent, Philip F. Allen, F. H. Hopcroft, Sir Eric Geddes, H. C. Minchin, Ernest …, Professor F. J. C. Hearnshaw, H. Parry, Dr. J. A. Nairn (Headmaster of merchant Taylors' School), Amicus, A., Alfred Bruce Douglas, L. Van Vliet, Crawfurd Price, Brodie Fraser, Edmund B. D'auvergne, Dilys Powell, H. Prosser Chanter, G. Elliot Smith F. R. S., Mathilde Verne, Charles L. Freeston, H. F., Commander A. T. Stewart R. N., G. E. T. Edalji, Pandora, St. John Adcock, D. J. Morgan, J. K., T. L. Tudor, Erikaye, G. M. Dawkin M. R. C. S., R. J. Barrett Financial Editor, Frederick Harker, Harold Cox,
... s Notebook Sleeplessness Again "The Highest French Mountain" Fechter City Churches "Physicians of the League" Golden-Rule ... Big Bags Expected Most Estates Teeming with Birds Peter Robinson Wilkinson Linguaphone Medicated and Oxygenated Water Multiple ...
1926 - Gale Group | Sunday Times HA GDA
Mandy K. S. Vink, Christien A. Schortinghuis, Antonina A Zabelinskaja-Mackova, Martin Fechter, Peter Pöchlauer, A.M.C.F. Castelijns, Jan H. van Maarseveen, Henk Hiemstra, Herfried Griengl, Hans E. Schoemaker, Floris P. J. T. Rutjes,
Abstract 5‐Hydroxypiperidin‐2‐one is a versatile building block for the preparation of potentially biologically active compounds. We detail an enantioselective biocatalytic approach towards its synthesis using ( S )‐hydroxynitrile lyase (HNL)‐mediated cyanohydrin formation, followed by hydrogenation. By adjusting the conditions of the latter step, we were able to obtain 5‐hydroxypiperidinone‐derived (bicyclic) N , N ‐acetals via an unprecedented reductive amination of the nitrile group, as well as form N ‐ ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2003 - Wiley | Advanced Synthesis & Catalysis
Stefan Fechter, Alexandros Terzis, Peter Ott, Bernhard Weigand, Jens von Wolfersdorf, Magali Cochet,
Impingement cooling effectiveness of gas turbine vanes and blades can be further increased due to the manufacturing feasibility of integrally cast airfoils which can provide narrow impingement cooling cavities. This study examines experimentally using the transient liquid crystal technique, and numerically using a commercial CFD package, the heat transfer characteristics of narrow impingement channels over their complete heat transfer area. The baseline configuration consists of a narrow impingement ...
Tópico(s): Turbomachinery Performance and Optimization
2013 - Elsevier BV | International Journal of Heat and Mass Transfer
Eric J. Fechter, Bogdan Olenyuk, Peter B. Dervan,
Fluorescent methods to detect specific double-stranded DNA sequences without the need for denaturation may be useful in the field of genetics. Three hairpin pyrrole-imidazole polyamides 2−4 that target their respective sequences 5'-WGGGWW-3', 5'-WGGCCW-3', and 5'-WGWWCW-3' (W = A or T) were conjugated to thiazole orange dye at the C-termini to examine their fluorescence properties in the presence and absence of match duplex DNA. The conjugates fluoresce weakly in the absence of DNA but showed significant ...
Tópico(s): Click Chemistry and Applications
2005 - American Chemical Society | Journal of the American Chemical Society
Eric J. Fechter, Bogdan Olenyuk, Peter B. Dervan,
Programmable bisintercalators: Symmetric synthetic DNA bisintercalators (see picture) based on the H-pin polyamide motif afford high affinity and programmable sequence specificity. The development of sequence-specific DNA bisintercalators has been an ongoing challenge in the field of bioorganic chemistry and molecular recognition. Since the first proposed model of intercalation by Lerman,1 the disruption of transcription or replication by helix unwinding and extension has become an attractive strategy ...
Tópico(s): Chemical Synthesis and Analysis
2004 - Wiley | Angewandte Chemie International Edition
Julius C. Holzschuh, Michael Mix, Juri Ruf, Tobias Hölscher, Jörg Kotzerke, Alexis Vrachimis, Paul Doolan, Harun Ilhan, Ioana M. Marinescu, Simon K. B. Spohn, Tobias Fechter, Dejan Kuhn, Peter Bronsert, Christian Gratzke, Radu Grosu, Sophia C. Kamran, Pedram Heidari, Thomas S.C. Ng, Arda Könik, Anca‐Ligia Grosu, Constantinos Zamboglou,
With the increased use of focal radiation dose escalation for primary prostate cancer (PCa), accurate delineation of gross tumor volume (GTV) in prostate-specific membrane antigen PET (PSMA-PET) becomes crucial. Manual approaches are time-consuming and observer dependent. The purpose of this study was to create a deep learning model for the accurate delineation of the intraprostatic GTV in PSMA-PET.
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2023 - Elsevier BV | Radiotherapy and Oncology
Eric J. Fechter, Bogdan Olenyuk, Peter B. Dervan,
Programmierbare Bisintercalatoren: Symmetrische synthetische DNA-Bisintercalatoren, die auf dem H-Brosche-Polyamidmotiv beruhen (siehe Bild), bieten hohe Affinität und programmierbare Sequenzspezifität. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z54231_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other ...
Tópico(s): Chemical Synthesis and Analysis
2004 - Wiley | Angewandte Chemie
Tilman Bostel, Ilias Sachpazidis, M. Splinter, Nina Bougatf, Tobias Fechter, Constantinos Zamboglou, Oliver Jäkel, Peter Huber, Dimos Baltas, Jürgen Debus, Nils H. Nicolay,
Background and purpose: To analyze deviations of the applied from the planned doses on a voxel-by-voxel basis for definitive prostate cancer radiotherapy depending on anatomic variations and imaging frequency. Materials and methods: Daily in-room CT imaging was performed in treatment position for 10 patients with prostate cancer undergoing intensity-modulated radiotherapy (340 fraction CTs). Applied fraction doses were recalculated on daily images, and voxel-wise dose accumulation was performed using ...
Tópico(s): Radiation Dose and Imaging
2019 - Frontiers Media | Frontiers in Oncology
Manuela Avi, Martin Fechter, Karl Gruber, Ferdinand Belaj, Peter Pöchlauer, Herfried Griengl,
Heterocyclic saturated five- and six-membered ring ketones sometimes bearing a methyl substituent were reacted with HCN under enzyme catalysis using recombinant hydroxynitrile lyase from Hevea brasiliensis, as a rule (S)-selective, and Prunus amygdalus, (R)-selective. The resulting cyanohydrins were stereochemically characterised. The steric outcome of these transformations was interpreted by molecular modelling.
Tópico(s): Plant biochemistry and biosynthesis
2004 - Elsevier BV | Tetrahedron
Doris Kelle, Dominik Fechter, Alexander Singer, Peter Pratje, Ilse Storch,
Tópico(s): Human-Animal Interaction Studies
2013 - Springer Science+Business Media | International Journal of Primatology
Constantinos Zamboglou, M. Carles, Tobias Fechter, Selina Kiefer, K. Reichel, Thomas F. Fassbender, Peter Bronsert, Goeran Koeber, Oliver Schilling, Juri Ruf, Martin Werner, Cordula A. Jilg, Dimos Baltas, Michael Mix, Anca‐Ligia Grosu,
Purpose: To evaluate the performance of radiomic features (RF) derived from PSMA PET for intraprostatic tumor discrimination and non-invasive characterization of Gleason score (GS) and pelvic lymph node status.Patients and methods: Patients with prostate cancer (PCa) who underwent [ 68 Ga]-PSMA-11 PET/CT followed by radical prostatectomy and pelvic lymph node dissection were prospectively enrolled (n=20).Coregistered histopathological gross tumor volume (GTV-Histo) in the prostate served as reference.133 ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2019 - Ivyspring International Publisher | Theranostics
Susan Peters, Yngvar Thomassen, Edeltraud Fechter-Rink, Hans Kromhout,
Objective- A case study was carried out to assess cement dust exposure and its determinants among construction workers and for comparison among workers in cement and concrete production.Methods- Full-shift personal exposure measurements were performed and samples were analysed for inhalable dust and its cement content. Exposure variability was modelled with linear mixed models.Results- Inhalable dust concentrations at the construction site ranged from 0.05 to 34 mg/m(3), with a mean of 1.0 mg/m( ...
Tópico(s): Air Quality and Health Impacts
2008 - Royal Society of Chemistry | Journal of Environmental Monitoring
Martin Fechter, Karl Gruber, Manuela Avi, Wolfgang Skranc, C. Schuster, Peter Pöchlauer, Kurt O. Klepp, Herfried Griengl,
3-Tetrahydrothiophenone (4) and 4-phenylthiobutan-2-one (7) were used as masked 2-butanone equivalents to give the corresponding cyanohydrins 5 (79 % yield, 91 % ee) and 8 (95 % yield, 96 % ee) in an enzymatic cyanohydrin reaction applying the hydroxynitrile lyase (HNL) from Hevea brasiliensis. After hydrolysis and desulphurisation the desired intermediate (S)-2-hydroxy-2-methylbutyric acid (10) was obtained with 99 % ee. Interestingly, when applying (R)-selective HNL from Prunus amygdalus again the (S)-cyanohydrin ...
Tópico(s): Biofuel production and bioconversion
2007 - Wiley | Chemistry - A European Journal
Franz Daliacker, Peter Fechter, Volker Mues,
The methylester of 3,4-dihydroxy-pyridine-6-carboxylic acid (1) reacts with bromochloromethane/potassjumcarbonate leading to the methylester of pyrido[3,4-d][1,3]-dioxole-6-onrhoxylic apid (2a). 2,3-Dihydroxy-pyridine (3a), 6-methyl- (3b), 5-chloro- (3c), and 5-bromo-2,3-dihydroxy-pyridine (3d) lead under the same conditions to the pyrido-[2,3-d][1,3]dioxole derivatives 4a, 4b, 4c, and 4d. The ester of 2,3-dihydroxy-pyridine-5-carboxylic acid (3e) and 4,6-dibromo-2,3-dihydroxy-pyridine (3f) also can be ...
Tópico(s): Organic Chemistry Synthesis Methods
1979 - De Gruyter | Zeitschrift für Naturforschung B
Arnoud J. Templeton, Valérie Dutoit, Richard Cathomas, Christian Rothermundt, Daniela Bärtschi, Cornelia Dröge, Oliver Gautschi, Markus Borner, Eva Fechter, Frank Stenner, Sun Young Rha, Beat P. Müller‐Stich, Ralph Schiess, Peter J. Wild, Jan H. Rüschoff, George N. Thalmann, Pierre‐Yves Dietrich, Ruedi Aebersold, Dirk Klingbiel, Silke Gillessen,
The phosphatase and tensin homolog (PTEN) tumor suppressor gene is deregulated in many advanced prostate cancers, leading to activation of the phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway and thus increased cell survival. To evaluate everolimus, an inhibitor of mTOR, in patients with metastatic castration-resistant prostate cancer (mCRPC), and to explore potentially predictive serum biomarkers by proteomics, the significance of PTEN status in tumor tissue, and ...
Tópico(s): Multiple Myeloma Research and Treatments
2013 - Elsevier BV | European Urology
Katrin Pansy, Julia Feichtinger, Barbara Ehall, Barbara Uhl, Miriam Sedej, David Roula, Beata Pursche, Axel Wolf, Manuel Zoidl, Elisabeth Steinbauer, Verena Gruber, Hildegard Greinix, Katharina Prochazka, Gerhard Thallinger, Ákos Heinemann, Christine Beham‐Schmid, Peter Neumeister, Tanja M. Wrodnigg, Karoline Fechter, Alexander Deutsch,
In tumor cells of more than 20 different cancer types, the CXCR4-CXCL12-axis is involved in multiple key processes including proliferation, survival, migration, invasion, and metastasis. Since data on this axis in diffuse large B cell lymphoma (DLBCL) are inconsistent and limited, we comprehensively studied the CXCR4-CXCL12-axis in our DLBCL cohort as well as the effects of CXCR4 antagonists on lymphoma cell lines in vitro. In DLBCL, we observed a 140-fold higher CXCR4 expression compared to non- ...
Tópico(s): Multiple Myeloma Research and Treatments
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Article „Der da sigelos wirt, dem sleht man die hant ab“. Zum Stand der hauptberuflichen Fechter nach mittelalterlichen Rechtsquellen was published on August 1, 1985 in the journal Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung (volume 102, issue 1).
Tópico(s): Historical Legal Studies and Society
1985 - De Gruyter | Zeitschrift der Savigny-Stiftung für Rechtsgeschichte Germanistische Abteilung
Susan Peters, Yngvar Thomassen, Edeltraud Fechter-Rink, Hans Kromhout,
A case study was carried out in 2006-2007 to assess the actual cement dust exposure among construction workers involved in a full-scale construction project and as a comparison among workers involved in various stages of cement and concrete production. Full-shift personal exposure measurements were performed for several job types. Inhalable dust and cement dust (based on analysis of elemental calcium) concentrations were determined. Inhalable dust exposures at the construction site ranged from 0. ...
Tópico(s): Occupational and environmental lung diseases
2009 - IOP Publishing | Journal of Physics Conference Series
M. Splinter, Tilman Bostel, Ilias Sachpazidis, Tobias Fechter, Constantinos Zamboglou, Oliver Jäkel, Peter Huber, Jürgen Debus, Dimos Baltas, Nils H. Nicolay,
Background and purpose: To analyze divergences between the planned and applied treatment doses for post-prostatectomy radiotherapy to the prostatic fossa on a voxel-by-voxel basis based on interfractional anatomic variations and imaging frequency. Materials and methods: For 10 patients receiving intensity-modulated postoperative radiotherapy to the prostatic fossa, position verification was carried out by daily in-room CT imaging in treatment position (340 fraction CTs). Applied fraction doses were ...
Tópico(s): Advanced X-ray and CT Imaging
2019 - Frontiers Media | Frontiers in Oncology
Peter B. Dervan, Adam T. Poulin-Kerstien, Eric J. Fechter, Benjamin S. Edelson,
Tópico(s): RNA Interference and Gene Delivery
2005 - Springer Science+Business Media | Topics in current chemistry
R. S. Fitzgerald, Peter Garger, Christoph Hauer, Hershel Raff, Laurence D. Fechter,
The purpose of this study was to determine the content of catecholamines (CA) in the cat carotid body before and after 0.5 h exposures to normoxic normocapnia [arterial O2 partial pressure (Pao2) 126 +/- 28 Torr, arterial CO2 partial pressure (Paco2) 36.4 +/- 1.5 Torr], hypoxic normocapnia (Pao2 25 +/- 3 Torr, Paco2 36.7 +/- 3.3 Torr), and normoxic hypercapnia (Pao2 132 +/- 13 Torr, Paco2 = 98.2 +/- 7.6 Torr). CA synthesis was blocked using alpha-methylparatyrosine methyl ester (AMPT) prior to alterations in the inspired air. There ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
1983 - American Physiological Society | Journal of Applied Physiology
Christian Bleilevens, Benedict M. Doorschodt, Tamara Fechter, Tim Grzanna, Alexander Theißen, Elisa A. Liehn, Thomas Breuer, René H. Tolba, Rolf Rossaint, Christian Stoppe, Peter Boor, Aileen Hill, Gregor Fabry,
Systemic and localized ischemia and reperfusion injury remain clinically relevant issues after organ transplantation and contribute to organ dysfunctions, among which acute kidney injury is one of the most common. An in vitro test-circuit for normothermic perfusion of porcine kidneys after warm ischemia was used to investigate the antioxidant properties of vitamin C during reperfusion. Vitamin C is known to enhance microcirculation, reduce endothelial permeability, prevent apoptosis, and reduce ...
Tópico(s): Anesthesia and Neurotoxicity Research
2019 - Multidisciplinary Digital Publishing Institute | Nutrients
Barbara Uhl, Katharina Prochazka, Karoline Fechter, Katrin Pansy, Hildegard Greinix, Peter Neumeister, Alexander Deutsch,
Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue (MALT), also known as MALT lymphomas. These arise at a wide range of different extranodal sites, with most cases affecting the stomach, the lung, the ocular adnexa and the thyroid. The small intestine is involved in a lower percentage of cases. Lymphoma growth in the early stages is associated with long-lasting chronic inflammation provoked by bacterial infections (e.g., ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2022 - | World Journal of Gastrointestinal Oncology
... witnessed the crime, as in the case of Peter Fechter, who bled to death in plain view of ...
Tópico(s): Eastern European Communism and Reforms
2013 - German Studies Association | German Studies Review
... any moment any day, as the death of Peter Fechter at the Wall in August 1962 illustrated. Also, ...
Tópico(s): European history and politics
1963 - Cambridge University Press | World Politics
Constantinos Zamboglou, Thomas F. Fassbender, Lina Steffan, Florian Schiller, Tobias Fechter, M. Carles, Selina Kiefer, Hans Christian Rischke, K. Reichel, Nina-Sophie Schmidt-Hegemann, Harun Ilhan, Alin Chirindel, Guillaume Nicolas, Christoph Henkenberens, Thorsten Derlin, Peter Bronsert, Panayiotis Mavroidis, Ronald C. Chen, Philipp T. Meyer, Juri Ruf, Anca‐Ligia Grosu,
Purpose Accurate definition of the intraprostatic gross tumor volume (GTV) is crucial for diagnostic and therapeutic approaches in patients with primary prostate cancer (PCa). The optimal methodology for contouring of GTV using Prostate specific membrane antigen positron emission tomography (PSMA-PET) information has not yet been defined. Methods and Materials PCa patients who underwent a [68Ga]PSMA-11-PET/CT followed by radical prostatectomy were prospectively enrolled (n = 20). Six observer teams with ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2019 - Elsevier BV | Radiotherapy and Oncology