Ingo Vernaleken, Thomas Siessmeier, Hans‐Georg Buchholz, Sebastian Härtter, Christoph Hiemke, Peter Stoeter, Frank Rösch, Peter Bartenstein, Gerhard Gründer,
The 'atypicality' of the antipsychotic drug, amisulpride, has been attributed to preferential extrastriatal binding. Previous investigations of striatal D2 receptor occupancy by amisulpride revealed conflicting results. The aim of this PET study was to measure the striatal occupancy by amisulpride and to correlate it with the corresponding drug plasma concentrations. Nine amisulpride-treated patients and 12 healthy volunteers serving as controls were studied with PET and [18F]desmethoxyfallypride. ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2004 - University of Oxford | The International Journal of Neuropsychopharmacology
Gerhard Gründer, Thomas Siessmeier, Christian Lange‐Asschenfeldt, Ingo Vernaleken, Hans‐Georg Buchholz, Peter Stoeter, Alexander Drzezga, Hartmut Lüddens, Frank Rösch, Peter Bartenstein,
Tópico(s): Neuroscience and Neuropharmacology Research
2001 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Joachim Rösch, Peter Barghoorn, Rolf Mülhaupt,
... glass-bead-reinforced poly(propylene) Joachim Rösch, Joachim Rösch Freiburger Materialforschungszentrum und Institut für Makromolekulare Chemie der Albert-Ludwigs Universitàt, Stefan-Meier Str. 31, D-79104 Freiburg i. Br., Federal Republic of GermanySearch for more papers by this authorPeter Barghoorn, Peter Barghoorn Freiburger Materialforschungszentrum und Institut für Makromolekulare Chemie ... more papers by this author Joachim Rösch, Joachim Rösch Freiburger Materialforschungszentrum und Institut für Makromolekulare Chemie der Albert-Ludwigs Universitàt, Stefan-Meier Str. 31, D-79104 Freiburg i. Br., Federal Republic of GermanySearch for more papers by this authorPeter Barghoorn, Peter Barghoorn Freiburger Materialforschungszentrum und Institut für Makromolekulare Chemie ...
Tópico(s): Polymer Science and Applications
1994 - Wiley | Macromolecular Rapid Communications
Ingo Vernaleken, Lisa Peters, Mardjan Raptis, Robert Lin, Hans‐Georg Buchholz, Yun Zhou, Oliver Winz, Frank Rösch, Peter Bartenstein, Dean F. Wong, Wolfgang Schäfer, Gerhard Gründer,
The high-affinity radioligand [ 18 F]fallypride (FP) is frequently used for quantification of striatal/extrastriatal D 2/3 receptors and the receptor occupancies of antipsychotics (APs). Its 110 minutes half-life allows long scan durations. However, the optimum scan duration is a matter of debate. This investigation focuses on scan-duration-related effects on simplified reference tissue model (SRTM) results and the time point of transient equilibrium in a large sample of dynamic FP positron emission ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2011 - SAGE Publishing | Journal of Cerebral Blood Flow & Metabolism
U. Wetterich, Hildegard Spahn‐Langguth, E. Mutschler, B Terhaag, Wolfgang Rösch, Peter Langguth,
Tópico(s): Alcohol Consumption and Health Effects
1996 - Springer Science+Business Media | Pharmaceutical Research
Sebastian Schäfer, Sebastian Kaufmann, Esther S. Rösch, Peter W. Roesky,
A comprehensive overview of the syntheses, properties and reactivities of divalent metallocenes of the lanthanides is presented.
Tópico(s): Magnetism in coordination complexes
2023 - Royal Society of Chemistry | Chemical Society Reviews
Nina El Najjar, Jihad El Andari, Christine Kaimer, Georg Fritz, Thomas C. Rösch, Peter L. Graumann,
ABSTRACT Like many bacteria, Bacillus subtilis possesses two DNA translocases that affect chromosome segregation at different steps. Prior to septum closure, nonsegregated DNA is moved into opposite cell halves by SftA, while septum-entrapped DNA is rescued by SpoIIIE. We have used single-molecule fluorescence microscopy and tracking (SMT) experiments to describe the dynamics of the two different DNA translocases, the cell division protein FtsA and the glycolytic enzyme phosphofructokinase (PfkA), ...
Tópico(s): Microtubule and mitosis dynamics
2018 - American Society for Microbiology | Applied and Environmental Microbiology
Urs G. Kormann, Verena Rösch, Péter Batáry, Teja Tscharntke, Kirill Márk Orci, Ferenc Samu, Christoph Scherber,
Aim Biodiversity across the globe is heavily eroded by intensified management at local and landscape scales. Species communities of calcareous grasslands, which are among Europe's most diverse habitats, are severely threatened by the cessation of appropriate traditional management, loss of habitat connectivity and simplification of the surrounding landscape. However, our understanding of these often interrelated factors remains limited, in particular for trait-mediated responses across taxa. Here, ...
Tópico(s): Plant Parasitism and Resistance
2015 - Wiley | Diversity and Distributions
Maria Isabel Osorio Garcia, Ramin Naraghi, Thomas Zumbrunn, J Rösch, Peter Hastreiter, Arnd Dörfler,
BACKGROUND AND PURPOSE: High-resolution MR imaging is useful for diagnosis and preoperative planning in patients with NVC. Because high-field MR imaging promises higher SNR and resolution, the aim of this study was to determine the value of high-resolution 3D-CISS and 3D-TOF MRA at 3T compared with 1.5T in patients with NVC. MATERIALS AND METHODS: Forty-seven patients with NVC, trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia were examined at 1.5T and 3T, including high-resolution 3D- ...
Tópico(s): Meningioma and schwannoma management
2012 - American Society of Neuroradiology | American Journal of Neuroradiology
Christoph Fehr, Igor Yakushev, Nina Hohmann, Hans‐Georg Buchholz, Christian Landvogt, Hanna Deckers, Alexandra Eberhardt, Marie Kläger, Michael N. Smolka, Armin Scheurich, Thomas F. Dielentheis, Lutz Schmidt, Frank Rösch, Peter Bartenstein, Gerhard Gründer, Mathias Schreckenberger,
All drugs of abuse induce a phasic dopamine release within the striatum that does not undergo habituation. Prolonged substance consumption impairs the natural function of the mesolimbic dopamine system, as shown by a decrease in the availability of striatal dopamine 2 (D(2)) receptors in patients suffering from cocaine, heroin, amphetamine, and alcohol dependence. However, it is unclear whether similar changes can also be observed in heavy-smoking nicotine-dependent smokers.In vivo D(2)/D(3) receptor ...
Tópico(s): Smoking Behavior and Cessation
2008 - American Psychiatric Association | American Journal of Psychiatry
U. Klinge, Marcel Binnebösel, R. Rösch, Peter R. Mertens,
Usually an abdominal wall hernia is regarded as a mechanical problem with a local defect which has to be closed by technical means. Despite the introduction of several therapeutic improvements, recurrent hernias still appear in 10-15%. Therefore, reasons for a recurrence are discussed in a more fundamental way. It is assumed that a failure mainly depends on the quality of the repair. Correspondingly, in principle, the close causal relationship between the technical component and its failure during ...
Tópico(s): Body Contouring and Surgery
2006 - Medknow | Journal of Minimal Access Surgery
B. Klosterhalfen, Petra Lynen, V. Schumpelick, Karsten Junge, U. Klinge, R. Rösch, Peter R. Mertens, Jochen Kirch,
Tópico(s): Sports injuries and prevention
2004 - Springer Science+Business Media | Langenbeck s Archives of Surgery
Zhongyi Si, R.S. Bhardwaj, R. Rösch, Peter Rene Merten, B. Klosterhalfen, U. Klinge,
Abstract Background. Recent findings of an impaired protein ratio of type I to type III procollagen showed a disturbed collagen metabolism in incisional hernia development. We analyzed the type I and type III procollagen messenger RNA to investigate whether these findings represent the altered extracellular matrix or a primary defect at the transcriptional level. Methods. We examined cultured skin fibroblasts of patients with incisional or recurrent incisional hernia in comparison with those without any ...
Tópico(s): Pelvic and Acetabular Injuries
2002 - Elsevier BV | Surgery
Dirk Manke, Peter Rösch, Kay Nehrke, Peter Börnert, Olaf Dössel,
Image processing was used as a fundamental tool to derive motion information from magnetic resonance (MR) images, which was fed back into prospective respiratory motion correction during subsequent data acquisition to improve image quality in coronary MR angiography (CMRA) scans. This reduces motion artifacts in the images and, in addition, enables the usage of a broader gating window than commonly used today to increase the scan efficiency. The aim of the study reported in this paper was to find ...
Tópico(s): Medical Imaging Techniques and Applications
2002 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Medical Imaging
Martin Storr, Hans–Dieter Allescher, Thomas Rösch, Peter Born, N. Weigert, Meinhard Classen,
Abstract Background: Diffuse esophageal spasm is a rare esophageal motility disorder for which there are no satisfactory pharmacologic alternatives for treatment. The aim of this study was to investigate whether botulinum toxin (BTX) injection is an effective short- and long-term treatment for patients with symptoms caused by diffuse esophageal spasm. Whether recurrence of clinical symptoms can be successfully retreated by BTX injection was also studied. Methods: Nine symptomatic patients (6 women, 3 men; ...
Tópico(s): Esophageal and GI Pathology
2001 - Elsevier BV | Gastrointestinal Endoscopy
E. Bertel, N. Memmel, W. Jacob, V. Dose, H. Netzer, G. Rosina, G. Rangelov, Georg Astl, Notker Rösch, Peter Knappe, Brett I. Dunlap, H. Saalfeld,
The unoccupied electronic levels of ${\mathrm{NaO}}_{2}$ and ${\mathrm{KO}}_{2}$ have been probed by inverse photoemission. In addition, excitation spectra of various core and valence levels have been recorded with use of x-ray absorption spectroscopy and electron-energy-loss spectroscopy. Results from a linear combination of Gaussian-type orbitals X\ensuremath{\alpha} (LCGTO-X\ensuremath{\alpha}) model cluster study and photoemission data previously reported give a coherent and detailed description of ...
Tópico(s): Advanced Chemical Physics Studies
1989 - American Physical Society | Physical review. B, Condensed matter
Kurt Lucas, Moritz Rosch, Peter Langguth,
Abstract Many diseases as well as acute conditions can lead to fatigue, which can be either temporary or chronic in nature. Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or COVID‐19 and chronic diseases like Parkinson's disease or multiple sclerosis are often associated with chronic fatigue. Oxidative stress and a resulting disturbance of mitochondrial function are likely to be common denominators for many forms ...
Tópico(s): Medical and Biological Ozone Research
2020 - Wiley | Archiv der Pharmazie
Alexander Hein, F. Demaria, Alexander Kern, Susanne Menzel, Fernando Rinaldi, Rudolf Rösch, Peter Unger,
We present a semiconductor disk laser with a fundamental emission at 920 nm which is frequency-doubled utilizing a bismuth triborate nonlinear crystal. The generated blue emission at 460 nm is the most suitable wavelength for display applications. The device layer design and the applied resonator geometry are discussed. Experimental results reveal overall optical-to-optical conversion efficiencies of up to 41.5% for the fundamental and up to 14.5% for the second-harmonic emission.
Tópico(s): Photonic and Optical Devices
2010 - Institute of Electrical and Electronics Engineers | IEEE Photonics Technology Letters
Thomas C. Rösch, Peter L. Graumann,
Conjugation of plasmid pLS20 from Bacillus subtilis is limited to a time window between early and late exponential growth. Genetic evidence has suggested that pLS20-encoded protein RcoLS20 represses expression of a large conjugation operon, whereas Rap protein RapLS20 relieves repression. We show that RapLS20 is a true antirepressor protein that forms dimers in vivo and in vitro and that it directly binds to the repressor protein RcoLS20 in a 1:1 stoichiometry. We provide evidence that RapLS20 binds ...
Tópico(s): Bacterial biofilms and quorum sensing
2015 - Elsevier BV | Journal of Biological Chemistry
Notker Rösch, Peter Knappe, P. Sandl, Andreas Görling, Brett I. Dunlap,
Transition metal clusters as models for surface phenomena are discussed and contrasted with gas phase clusters. The accuracy of ab initio and local density methods for transition metal systems is briefly compared. The linear combination of Gaussian-type orbitale (LCGTO) Xα approach is presented as an efficient method to calculate the electronic structure of such systems within the local density functional theory. Gaussian broadening of the one-electron levels is used to both mimic the embedding of ...
Tópico(s): Molecular Junctions and Nanostructures
1989 - American Chemical Society | ACS symposium series
Dalia Kaisarly, D. J. Meierhofer, Moataz El Gezawi, Peter Rösch, Karl‐Heinz Kunzelmann,
This investigation evaluated the effect of flowable liners beneath a composite restoration applied via different methods on the pattern of shrinkage vectors.Forty molars were divided into five groups (n = 8), and cylindrical cavities were prepared and bonded with a self-etch adhesive (AdheSe). Tetric EvoCeram Bulk Fill (TBF) was used as the filling material in all cavities. The flowable liners Tetric EvoFlow Bulk Fill (TEF) and SDR were used to line the cavity floor. In gp1-TBF, the flowable composite ...
Tópico(s): Dental Implant Techniques and Outcomes
2021 - Springer Nature | Clinical Oral Investigations
Jing Dong, Carlo Maj, Spiridon Tsavachidis, Quinn T. Ostrom, Puya Gharahkhani, Lesley Anderson, Anna H. Wu, Weimin Ye, Leslie Bernstein, Oleg Borisov, Julia Schröder, Wong‐Ho Chow, Marilie D. Gammon, Geoffrey Liu, Carlos Caldas, Paul D.P. Pharoah, Harvey A. Risch, Andrea May, Christian Gerges, Mario Anders, Marino Venerito, Thomas Schmidt, Jakob R. Izbicki, Arnulf H. Hölscher, Brigitte Schumacher, Yogesh K. Vashist, Horst Neuhaus, Thomas Rösch, Michael Knapp, Peter Krawitz, Anne C. Böhmer, Prasad G. Iyer, Brian J. Reid, Jesper Lagergren, Nicholas J. Shaheen, Douglas A. Corley, Ines Gockel, Rebecca C. Fitzgerald, Michael B. Cook, David C. Whiteman, Thomas L. Vaughan, Johannes Schumacher, Aaron P. Thrift, Jing Dong, Carlo Maj, Spiridon Tsavachidis, Quinn T. Ostrom, Puya Gharahkhani, Lesley Anderson, Anna H. Wu, Weimin Ye, Leslie Bernstein, Oleg Borisov, Julia Schröder, Wong‐Ho Chow, Marilie D. Gammon, Geoffrey Liu, Carlos Caldas, Paul D.P. Pharoah, Harvey A. Risch, Andrea May, Christian Gerges, Mario Anders, Marino Venerito, Thomas Schmidt, Jakob R. Izbicki, Arnulf H. Hölscher, Brigitte Schumacher, Yogesh K. Vashist, Horst Neuhaus, Thomas Rösch, Michael Knapp, Peter Krawitz, Anne C. Böhmer, Prasad G. Iyer, Brian J. Reid, Jesper Lagergren, Nicholas J. Shaheen, Douglas A. Corley, Ines Gockel, Rebecca C. Fitzgerald, Michael B. Cook, David C. Whiteman, Thomas L. Vaughan, Johannes Schumacher, Aaron P. Thrift,
Background & AimsEsophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for these conditions. However, potential sex differences in genetic associations with BE/EA remain largely unexplored.MethodsGiven strong genetic overlap, BE and EA cases were combined into ...
Tópico(s): Cancer-related gene regulation
2020 - Elsevier BV | Gastroenterology
Dalia Kaisarly, Moataz El Gezawi, Andreas Keßler, Peter Rösch, Karl‐Heinz Kunzelmann,
Abstract Objectives Sufficient depth of cure allows bulk-fill composites to be placed with a 4-mm thickness. This study investigated bulk versus incremental application methods by visualizing shrinkage vectors in flowable bulk-fill and conventional composites. Materials and methods Cylindrical cavities (diameter = 6 mm, depth = 4 mm) were prepared in 24 teeth and then etched and bonded with OptiBond FL (Kerr, Italy). The composites were mixed with 2 wt% radiolucent glass beads. In one group, smart dentin ...
Tópico(s): Endodontics and Root Canal Treatments
2020 - Springer Nature | Clinical Oral Investigations
Dalia Kaisarly, Moataz El Gezawi, Guangyun Lai, Jian Feng Jin, Peter Rösch, Karl‐Heinz Kunzelmann,
Tópico(s): Anatomy and Medical Technology
2017 - Springer Nature | Clinical Oral Investigations
Dalia Kaisarly, Moataz El Gezawi, Xiaohui Xu, Peter Rösch, Karl‐Heinz Kunzelmann,
Polymerization shrinkage of dental resin composites leads to stress build-up at the tooth-restoration interface that predisposes the restoration to debonding. In contrast to the heterogeneity of enamel and dentin, this study investigated the effect of boundary conditions in artificial cavity models such as ceramic and Teflon. Ceramic serves as a homogenous substrate that provides optimal bonding conditions, which we presented in the form of etched and silanized ceramic in addition to an etched, ...
Tópico(s): Endodontics and Root Canal Treatments
2017 - Elsevier BV | Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials
Yu‐Chih Chiang, Peter Rösch, Alp Dabanoğlu, Chun‐Pin Lin, Reinhard Hickel, Karl‐Heinz Kunzelmann,
The aim of this study was to develop a method to experimentally determine and visualize the direction and amount of polymerization shrinkage. We modified a composite to include 1.5 wt% traceable glass beads. A cylindrical cavity (6 mm diameter, 3 mm height) was restored with this traceable composite, with and without dentin adhesive, and digitized with high-resolution micro-computed tomography (μCT). Image segmentation was performed to extract the glass beads from the acquired 3D μCT images (uncured ...
Tópico(s): Endodontics and Root Canal Treatments
2009 - Elsevier BV | Dental Materials
Dirk Manke, Kay Nehrke, Peter Börnert, Peter Rösch, Olaf Dössel,
To assess respiratory motion models for coronary magnetic resonance angiography (CMRA). In this study various motion models that describe the respiration-induced 3D displacements and deformations of the main coronary arteries were compared.Multiple high-resolution 3D coronary MR images were acquired in healthy volunteers using navigator-based respiratory gating, each depicting the coronary vessels at different respiratory motion states. In the images representing the different inspiratory states ...
Tópico(s): Cardiac Imaging and Diagnostics
2002 - Wiley | Journal of Magnetic Resonance Imaging
Juergen Weese, Peter Rösch, Thomas Netsch, Thomas Blaffert, M. Quist,
For gray-value based multi-modality registration the similarity measure is essential. Excellent results have been obtained with mutual information for various modality combinations. In this contribution we consider local correlation as similarity measure for multi-modality registration. Using a software phantom it is analyzed why local correlation is suitable for this registration task whereas direct gray-value correlation itself is usually not. It is shown that registration with local correlation ...
Tópico(s): Image Retrieval and Classification Techniques
1999 - Springer Science+Business Media | Lecture notes in computer science
Dieter König, I. Quint, Peter Rösch, Bernhard C. Bayer,
Moisture layers with low layer conductivity are characterized by low power dissipation, e.g. 50 mW for the epoxy resin model post insulator under investigation. Under those conditions, no temperature-related dry zones appear, but micro partial discharges (PDs) cannot be excluded. The appearance of these discharges depends on the voltage stress, the surface properties, and the relevant climatic conditions. Experiments on moisture layers with low layer conductivity have been performed in test setups ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
1989 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Electrical Insulation
Ralf Kempkens, Peter Rösch, Louise Scott, Jörg Zettel,
Advanced software engineering principles imply the management of quality and process based on data from measurement. Such quality management can only be performed efficiently if it is well supported with tools that are carefully selected, integrated and used in the measurement program. Realizing such support is non-trivial because tools can be used in many aspects of measurement. In this paper we describe a framework for setting up measurement tool support for software development processes. The ...
Tópico(s): Software System Performance and Reliability
2000 - Springer Science+Business Media | Lecture notes in computer science