Gil I. Wolfe, Henry J. Kaminski, Inmaculada Aban, Greg Minisman, Hui‐Chien Kuo, Alexander Marx, Philipp Ströbel, Claudio Mazia, Joël Oger, Gabriel Cea, Jeannine M. Heckmann, Amelia Evoli, Wilfred A. Nix, Emma Ciafaloni, Giovanni Antonini, Rawiphan Witoonpanich, John King, Said R. Beydoun, Colin Chalk, Alexandru Barboi, Anthony A. Amato, Aziz Shaibani, Bashar Katirji, Bryan Lecky, Camilla Buckley, Angela Vincent, Elza Dias‐Tosta, Hiroaki Yoshikawa, Márcia Waddington‐Cruz, Michael Pulley, Michael H. Rivner, Anna Kostera‐Pruszczyk, Robert M. Pascuzzi, Carlayne E. Jackson, Jan J.G.M. Verschuuren, Janice M. Massey, John T. Kissel, Lineu César Werneck, Michael Benatar, Richard J. Barohn, Rup Tandan, Tahseen Mozaffar, Nicholas J. Silvestri, Robin Conwit, Joshua Sonett, Alfred Jaretzki, John Newsom–Davis, Gary Cutter, Gary Cutter, Inmaculada Aban, Greg Minisman, Michelle Feese, Hui‐Chien Kuo, John Newsom–Davis, Gil I. Wolfe, Henry J. Kaminski, Alfred Jaretzki, Joshua Sonett, Claudio Mazia, Valeria Saluto, Moisés Rosenberg, Valeria Alvarez, Lisa A. Rocca Rey, John King, Helmut Butzkueven, John Goldblatt, John C. Carey, John R. Pollard, Stephen Reddel, Nicholas Handel, Brian C. McCaughan, Linda Pallot, Márcia Waddington‐Cruz, Ricardo Novis, Carlos Henrique Ribeiro Boasquevisque, Elza Dias‐Tosta, Rubens N. Morato-Fernandez, Manoel Ximenes, Lineu César Werneck, Rosana Hermínia Scola, Paulo Soltoski, Colin Chalk, Fraser Moore, David S. Mulder, Lisa Wadup, Joël Oger, Michele Mezei, Kenneth G. Evans, Theresa Jiwa, Anne Schaffar, Chris White, Cory Toth, Gary Gelfand, Susan P. Wood, Elizabeth Pringle, Jocelyn Zwicker, Donna E. Maziak, Farid M. Shamji, Sudhir Sundaresan, Andrew Seely, Gabriel Cea, Renato Verduga, Alberto Aguayo, Sebastian Jander, Philipp Zickler, Michael D. Klein, Alexander Marx, Philipp Ströbel, Cleo‐Aron Weis, Arthur Melms, Felix Bischof, Hermann Aebert, Gerhard Ziemer, Wilfred A. Nix, Björn Thümler, Thomas Wilhem-Schwenkmezger, Eckhard Mayer, Berthold Schalke, Peter Pöschel, Gisela Hieber, Karsten Wiebe, Giovanni Antonini, Alessandro Clemenzi, V. Ceschin, Erino Angelo Rendina, Federico Venuta, Stefania Morino, Elisabetta Bucci, Luca Durelli, A. Tavella, Marinella Clerico, Giulia Contessa, P. Borasio, Amelia Evoli, Serenella Servidei, Pierluigi Granone, Renato Mantegazza, E. Berta, L. Novellino, Luisa Spinelli, Masakatsu Motomura, Hidenori Matsuo, Takeshi Nagayasu, Hiroaki Yoshikawa, Masaharu Takamori, Makoto Oda, Isao Matsumoto, Yutaka Furukawa, Daisuke Noto, Yuko Motozaki, Kazuo Iwasa, Daisuke Yanase, Guillermo García Ramos, Bernardo Cacho‐Díaz, Lorenzo de la Garza, Anna Kostera‐Pruszczyk, Marta Lipowska, Hubert Kwieciński, Anna Potulska‐Chromik, Tadeusz Orłowski, Ana Silva, Marta Feijo, Antônio Hilário Alves Freitas, Jeannine M. Heckmann, Andrew Frost, Edward Pan, Lawrence Tucker, Johan Rossouw, Fiona Drummond, Isabel Illa, Jorge Díaz, Carlos León, Jiann‐Horng Yeh, Hou‐Chang Chiu, Yei‐San Hsieh, Rawiphan Witoonpanich, Supoch Tunlayadechanont, Sukasom Attanavanich, Jan J.G.M. Verschuuren, C.S.M. Straathof, Maarten J. Titulaer, Michel I.M. Versteegh, Arda Pels, Yvonne Krum, Camilla Buckley, Maria Isabel Leite, Angela Vincent, David Hilton‐Jones, C Ratnatunga, Maria Elena Farrugia, Richard Petty, James Overell, Alan Kirk, Andrew Gibson, Christopher McDermott, David Hopkinson, Bryan Lecky, David Watling, Dot Marshall, Sam Saminaden, Deborah Davies, Charlotte F. Dougan, Siva Sathasivam, Richard L. Page, Jon Sussman, John Ealing, P. Krysiak, Anthony A. Amato, Mohammad Salajegheh, Michael T. Jaklitsch, Kristen Roe, Tetsuo Ashizawa, Robert G. Smith, Joseph Zwischenberg, Penny Stanton, Alexandru Barboi, Safwan Jaradeh, William B. Tisol, Mario Gasparri, George B. Haasler, Mary Yellick, Cedric Dennis, Richard J. Barohn, Mamatha Pasnoor, Mazen M. Dimachkie, April McVey, Gary Gronseth, Arthur Dick, Jeffrey B. Kramer, Melissa Currence, Laura Herbelin, Jerry M. Belsh, George Li, John Langenfeld, Mary Ann Mertz, Michael Benatar, Taylor Harrison, Seth Force, Sharon Usher, Said R. Beydoun, Frank Y. Lin, Steve R. DeMeester, Salem Akhter, Ali Malekniazi, Gina Avenido, Brian A. Crum, Margherita Milone, Stephen D. Cassivi, Janet Fisher, Emma Ciafaloni, Chad Heatwole, Thomas D. Watson, James Hilbert, Alexis M. Smirnow, B. Jane Distad, Michael D. Weiss, Douglas Wood, Joanna Haug, Raina M. Ernstoff, Jingyang Cao, Gary W. Chmielewski, Robert Welsh, Robin Duris, Laurie Gutmann, Gauri Pawar, Geoffrey M. Graeber, Patricia Altemus, Christopher Nance, Ludwig Gutmann, Carlayne E. Jackson, Patrick Grogan, John Calhoon, Pamela Kittrell, Deborah L. Myers, Ghazala Hayat, Keith S. Naunheim, Susan Eller, Eve Holzemer, Bashar Katirji, Amer Alshekhlee, Jason Robke, Brenda Karlinchak, Jonathan Katz, Robert G. Miller, Ralph Roan, Dallas Forshew, John T. Kissel, Bakri Elsheikh, Patrick Ross, Sharon Chelnick, Richard A. Lewis, Agnes Acsadi, Frank A. Baciewicz, Stacey Masse, Janice M. Massey, Vern C. Juel,
Background The Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone (MGTX) showed that thymectomy combined with prednisone was superior to prednisone alone in improving clinical status as measured by the Quantitative Myasthenia Gravis (QMG) score in patients with generalised non-thymomatous myasthenia gravis at 3 years. We investigated the long-term effects of thymectomy up to 5 years on clinical status, medication requirements, and adverse events. Methods We did a rater- ...
Elsevier BV
... Yaakov Ariel, Dan Miron, Maja Ščrbačić, Peter W. Marx, Philipp von Wussow, Anna Hájková, Yaron Ben-Naeh, Michael ...
Tópico(s): Islamic Studies and History
2005 - University of Chicago Press | The Journal of Religion
Philipp Marx, Angelo Romano, Roland A. Fischer, Ignazio Roppolo, Marco Sangermano, Frank Wiesbrock,
... Volume-Controlling Additives in Thiol–Ene Reactions Philipp Marx, Philipp MarxSearch for more papers by this authorAngelo Romano, ... WiesbrockSearch for more papers by this author Philipp Marx, Philipp MarxSearch for more papers by this authorAngelo Romano, ...
Tópico(s): Advanced Polymer Synthesis and Characterization
2019 - Wiley | Macromolecular Materials and Engineering
Alberto M. Marchevsky, Alex Marx, Philipp Ströbel, Saul Suster, Federico Venuta, Mirella Marino, Samuel A. Yousem, Maureen F. Zakowski,
... consisting of pathologists and surgeons (Alberto Marchevsky, Alexander Marx, Saul Suster, Maureen Zakowski, Federico Venuta, Sam Youssem, and Philipp Ströbel) was assembled to review literature relevant to ...
Tópico(s): Vascular Malformations and Hemangiomas
2011 - Elsevier BV | Journal of Thoracic Oncology
Björn Klaes, Sören Thiele‐Bruhn, Gerhard Wörner, Carmen Höschen, Carsten W. Mueller, Philipp Marx, Helge W. Arz, Sonja Breuer, Rolf Kilian,
Redox-driven biogeochemical cycling of iron plays an integral role in the complex process network of ecosystems, such as carbon cycling, the fate of nutrients and greenhouse gas emissions. We investigate Fe-(hydr)oxide (trans)formation pathways from rhyolitic tephra in acidic topsoils of South Patagonian Andosols to evaluate the ecological relevance of terrestrial iron cycling for this sensitive fjord ecosystem. Using bulk geochemical analyses combined with micrometer-scale-measurements on individual ...
Tópico(s): Heavy metals in environment
2023 - Nature Portfolio | Scientific Reports
Denise Müller, Paolo Mazzeo, Raphael Koch, Mark-Sebastian Bösherz, Stefan Welter, Alexander von Hammerstein‐Equord, Marc Hinterthaner, Lucia Cordes, Djeda Belharazem, Alexander Marx, Philipp Ströbel, Stefan Küffer,
Abstract Background Multi-omics studies have shown a high and lack of common driver mutations in most thymomas (TH) and thymic carcinomas (TC) that hamper the development of novel treatment approaches. However, deregulation of apoptosis has been proposed as a common hallmark of TH and TC. BH3 profiling can be utilized to study the readiness of living cancer cells to undergo apoptosis and their dependency on pro-survival BCL-2 family proteins. Methods We screened a cohort of 62 TH and TC patient samples ...
Tópico(s): Ubiquitin and proteasome pathways
2021 - BioMed Central | BMC Medicine
Alexander Fichtner, Annika Richter, Simon Filmar, Stefan Kircher, Andreas Rosenwald, Stefan Küffer, Daniel Nettersheim, Christoph Oing, Alexander Marx, Philipp Ströbel, Felix Bremmer,
Primary mediastinal germ cell tumours (PMGCTs) are rare mediastinal neoplasms, and their diagnosis can be challenging, owing to small biopsy samples. The aim of this study was to develop a diagnostic algorithm using immunohistochemical staining, with a focus on novel markers, and molecular analysis of isochromosome 12p [i(12p)].Paraffin-embedded tissues of 32 mediastinal tumours were analysed with immunohistochemical staining for sal-like transcription factor 4 (SALL4), Lin-28 homologue A (LIN28), octamer- ...
Tópico(s): Sarcoma Diagnosis and Treatment
2021 - Wiley | Histopathology
Saskia Mitreuter, Marie Kaiser, Sophie Roupetz, Barbara Stelzl-Marx, Philipp Kuwert, Heide Glaesmer,
Children Born of War (CBOW) are important but largely uninvestigated populations. As a result of being fathered by a foreign soldier and born to a local mother, these children often struggle with identity issues and search for their absent fathers their whole lives. Despite CBOW being a part of every society, which has been involved in armed conflicts, there is almost no systematic research about them. We provided a systematic insight into issues of identity that many CBOW face throughout their lives ...
Tópico(s): Gender Roles and Identity Studies
2019 - Springer Science+Business Media | Journal of Child and Family Studies
Helen Dinter, Hanibal Bohnenberger, Julia Beck, Kirsten Bornemann-Kolatzki, Ekkehard Schütz, Stefan Küffer, Lukas Klein, Teri J. Franks, Anja C. Roden, Alexander Emmert, Marc Hinterthaner, Mirella Marino, Luka Brčić, Helmut Popper, Cleo‐Aron Weis, Giuseppe Pelosi, Alexander Marx, Philipp Ströbel,
IntroductionThe WHO classification of pulmonary neuroendocrine tumors (PNETs) is also used to classify thymic NETs (TNETs) into typical and atypical carcinoid (TC and AC), large cell neuroendocrine carcinoma (LCNEC), and small cell carcinoma (SCC), but little is known about the usability of alternative classification systems.MethodsOne hundred seven TNET (22 TC, 51 AC, 28 LCNEC, and 6 SCC) from 103 patients were classified according to the WHO, the European Neuroendocrine Tumor Society, and a grading- ...
Tópico(s): Neuroendocrine Tumor Research Advances
2019 - Elsevier BV | Journal of Thoracic Oncology
Petr Neugebauer, Dominik Bloos, R. Marx, Philipp Lutz, Michal Kern, David Aguilà, J. Vaverka, Oleksii Laguta, Carolin Dietrich, Rodolphe Clérac, Joris van Slageren,
Electron paramagnetic resonance (EPR) is a powerful technique to investigate the electronic and magnetic properties of a wide range of materials. We present the first combined terahertz (THz) field and frequency domain electron paramagnetic resonance (HFEPR/FDMR) spectrometer designed to investigate the electronic structure and magnetic properties of molecular systems, thin films and solid state materials in a very broad frequency range of 85-1100 GHz. In this paper, we show high resolution frequency- ...
Tópico(s): Magnetism in coordination complexes
2018 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Sharaf-Eldin Shehada, Daniel Wendt, Davina Peters, Fanar Mourad, Philipp Marx, Matthias Thielmann, Philipp Kahlert, Alexander Lind, Rolf Alexander Jánosi, Tienush Rassaf, Peter‐Michael Rath, Martin Thoenes, Heinz Jakob, Mohamed El Gabry,
Transcatheter aortic valve implantation (TAVI) is the standard therapy for high-risk patients with aortic stenosis (AS). TAVI-outcomes are widely investigated in comparison to surgical aortic valve replacement (SAVR), but less is known about infectious complications after TAVI. We aimed to compare early and mid-term infectious outcomes of patients undergoing TAVI or SAVR.The present study is a prospective single-centre study including 200 consecutive patients between 06/2014-03/2015 undergoing TAVI ( ...
Tópico(s): Aortic Disease and Treatment Approaches
2018 - AME Publishing Company | Journal of Thoracic Disease
Alexander Marx, Philipp Ströbel, Cleo‐Aron Weis,
Abstract: Myasthenia gravis (MG) is an autoantibody mediated autoimmune disease characterized by skeletal muscle fatigability and weakness through different types of immune attacks against various proteins of the postsynaptic membrane or in the neuromuscular cleft of the neuromuscular junction. In a subset of patients with autoantibodies against the muscle type acetylcholine receptors (AChRs) there is strong evidence that the thymus is involved in the pathogenesis of MG, while its role is questionable ...
Tópico(s): Pituitary Gland Disorders and Treatments
2018 - AME Publishing Company | Mediastinum
Produção Nacional
Revisado por pares
Gil I. Wolfe, Henry J. Kaminski, Inmaculada Aban, Greg Minisman, Hui‐Chien Kuo, Alexander Marx, Philipp Ströbel, Claudio Mazia, Joël Oger, Gabriel Cea, Jeannine M. Heckmann, Amelia Evoli, Wilfred A. Nix, Emma Ciafaloni, Giovanni Antonini, Rawiphan Witoonpanich, John King, Said R. Beydoun, Colin Chalk, Alexandru Barboi, Anthony A. Amato, Aziz Shaibani, Bashar Katirji, Bryan Lecky, Camilla Buckley, Angela Vincent, Elza Dias‐Tosta, Hiroaki Yoshikawa, Márcia Waddington‐Cruz, Michael Pulley, Michael H. Rivner, Anna Kostera‐Pruszczyk, Robert M. Pascuzzi, Carlayne E. Jackson, Guillermo Ramos, Jan J.G.M. Verschuuren, Janice M. Massey, John T. Kissel, Lineu César Werneck, Michael Benatar, Richard J. Barohn, Rup Tandan, Tahseen Mozaffar, Robin Conwit, Joanne Odenkirchen, Joshua Sonett, Alfred Jaretzki, John Newsom–Davis, Gary Cutter,
Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence of its benefit. We conducted a multicenter, randomized trial comparing thymectomy plus prednisone with prednisone alone.We compared extended transsternal thymectomy plus alternate-day prednisone with alternate-day prednisone alone. Patients 18 to 65 years of age who had generalized nonthymomatous myasthenia gravis with a disease duration of less than 5 years were included if they had Myasthenia ...
Tópico(s): Peripheral Neuropathies and Disorders
2016 - Massachusetts Medical Society | New England Journal of Medicine
Alexander Marx, Philipp Ströbel, Sunil Badve, Lara Chalabreysse, John Chan, Gang Chen, Laurence de Leval, Frank Detterbeck, Nicolas Girard, James Huang, Michael Kurrer, Libero Lauriola, Mirella Marino, Yoshihiro Matsuno, Thierry Jo Molina, Kiyoshi Mukai, Andrew G. Nicholson, Daisuke Nonaka, Ralf J. Rieker, Juan Rosaí, Enrico Ruffini, William D. Travis,
Introduction:The 2004 version of the World Health Organization classification subdivides thymic epithelial tumors into A, AB, B1, B2, and B3 (and rare other) thymomas and thymic carcinomas (TC). Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies.Methods:To overcome this problem, hematoxylin-eosin– ...
Tópico(s): Neuroblastoma Research and Treatments
2014 - Elsevier BV | Journal of Thoracic Oncology
Patrick Adam, Samy Hakroush, Ilse Hofmann, Sonja Reidenbach, Alexander Marx, Philipp Ströbel,
Tópico(s): Vascular Tumors and Angiosarcomas
2014 - Springer Science+Business Media | Virchows Archiv
Anna Green, Alexander Marx, Philipp Ströbel, Marianne Mason, Eric Lim, Simon Jordan, George Ladas, Michael Dusmet, Alexandra Rice, Andrew G. Nicholson,
Aims The current WHO classification of thymic epithelial neoplasms describes type A and type AB thymomas as behaving ‘like benign neoplasms’. However, recent published data suggest that rare cases may show more aggressive behaviour. The aim of this study was to assess the frequency of atypical cases, and to determine whether atypia is associated with more advanced disease. Methods and results One hundred and twenty‐one thymomas (type A, n = 68; type AB , n = 53) were retrospectively reviewed for ‘atypical’ ...
Tópico(s): Meningioma and schwannoma management
2014 - Wiley | Histopathology
Reinhild Klein, Alexander Marx, Philipp Ströbel, Berthold Schalke, Wilfred A. Nix, Nick Willcox,
Autoimmune associations in myasthenia gravis (MG)-patients and their relatives have not been re-assessed since their separation into early- or late-onset MG (EOMG, LOMG), or thymoma-associated MG. Here, we analysed 226 EOMG-, 97 LOMG-, and 150 thymoma-patients for autoimmune disorders in themselves and their relatives. From 283 of them sera were tested for different organ- and non-organ-specific autoantibodies (autoAbs) by immunofluorescence test (IFT) and ELISA; genotyping was performed in 213 patients. ...
Tópico(s): Peripheral Neuropathies and Disorders
2013 - Elsevier BV | Human Immunology
Anja von Au, Matthaeus Vasel, Sabrina Kraft, Carla Sens, Norman Hackl, Alexander Marx, Philipp Stroebel, Jörg Hennenlotter, Tilman Todenhöfer, Arnulf Stenzl, Sarah Schott, Hans‐Peter Sinn, Antoinette Wetterwald, Justo Lorenzo Bermejo, Marco Cecchini, Inaam A. Nakchbandi,
Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation. The relative contribution of local and circulating fibronectin to blood vessel formation in vivo remains unknown despite evidence for unexpected roles of circulating fibronectin in various diseases. Using transgenic mouse models, we established that circulating fibronectin facilitates the growth of bone metastases by enhancing blood vessel formation and ...
Tópico(s): Cellular Mechanics and Interactions
2013 - Elsevier BV | Neoplasia
Inga‐Marie Schaefer, Patrick Zardo, S Freermann, Alexander Marx, Philipp Ströbel, Stefan Fischer,
Tópico(s): Neuroendocrine Tumor Research Advances
2013 - Springer Science+Business Media | Virchows Archiv
Thomas Harnath, Alexander Marx, Philipp Ströbel, Edwin Bölke, Reinhart Willers, Stephan Gripp,
To evaluate prognostic factors of thymic epithelial tumors (TETs) with particular reference to histology and the dose-response relationship of adjuvant radiotherapy.Retrospective study with central pathological review on patients resected for TET between 1966 and 2004 at a single institution. Prognostic factors were identified using Cox regression analysis.From 93 patients with TET, 33.3% relapsed and 47.3% died. Cause of death was known in 64% and attributed to TET in 25%. Myasthenia gravis was ...
Tópico(s): Pituitary Gland Disorders and Treatments
2012 - Elsevier BV | Journal of Thoracic Oncology
Peter K. Gregersen, Roman Kosoy, Annette T. Lee, Janine A. Lamb, Jon Sussman, David McKee, Kim R. Simpfendorfer, R. Pirskanen‐Matell, Fredrik Piehl, Qiang Pan‐Hammarström, Jan J.G.M. Verschuuren, Maarten J. Titulaer, Erik H. Niks, Alexander Marx, Philipp Ströbel, Björn Tackenberg, Michael Pütz, Angelina Maniaol, Ahmed Elsais, Chantal Tallaksen, Hanne F. Harbo, Benedicte A. Lie, Soumya Raychaudhuri, Paul I. W. de Bakker, Arthur Melms, Henri‐Jean Garchon, Nicholas Willcox, Lennart Hammarström, Michael F. Seldin,
The objective of this study is to comprehensively define the genetic basis of early onset myasthenia gravis (EOMG).We have carried out a 2-stage genome-wide association study on a total of 649 North European EOMG patients. Cases were matched 1:4 with controls of European ancestry. We performed imputation and conditional analyses across the major histocompatibility complex, as well as in the top regions of association outside the human leukocyte antigen (HLA) region.We observed the strongest association ...
Tópico(s): Protein Tyrosine Phosphatases
2012 - Wiley | Annals of Neurology
Ralf Hildenbrand, Heike Allgayer, Alexander Marx, Philipp Stroebel,
Importance of the field: The serine protease urokinase-type plasminogen activator (uPA) and its receptor uPAR as well as two specific inhibitors, the plasminogen activator inhibitor type-1 (PAI-1) and type-2 (PAI-2), are involved in the control of extracellular matrix turnover and tumor growth. Data accumulating over the past 20 years have made increasingly clear that the uPA system has a multifunctional role in neoplastic evolution, affecting cancer cell proliferation, tumor angiogenesis, adhesion ...
Tópico(s): Peptidase Inhibition and Analysis
2010 - Taylor & Francis | Expert Opinion on Investigational Drugs
Rainer Guthoff, Alexander Marx, Philipp Stroebel,
Purpose: The etiology of ocular surface squamous neoplasia is unknown. Possible etiologic factors are physical and/or viral damage by human papillomavirus (HPV), especially in Sub-saharian populations. This study focused on the presence of human papillomavirus in ocular surface squamous neoplasia in comparison to pterygia and normal conjunctiva. Methods: Thirty-one consecutive samples of ocular surface squamous neoplasia from a single institution (24 conjunctival intraepithelial neoplasias of various ...
Tópico(s): Cervical Cancer and HPV Research
2009 - Taylor & Francis | Current Eye Research
Johanna Manner, Bernhard Radlwimmer, Peter Hohenberger, Katharina Mößinger, Stefan Küffer, Christian Sauer, Djeda Belharazem, Andreas Zettl, Jean‐Michel Coindre, Christian Hallermann, Jörg T. Hartmann, D. Katenkamp, Kathrin Katenkamp, Patrick Schöffski, Raf Sciot, Agnieszka Woźniak, Peter Lichter, Alexander Marx, Philipp Ströbel,
Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24. ...
Tópico(s): Sarcoma Diagnosis and Treatment
2009 - Elsevier BV | American Journal Of Pathology
Carina Jehn, Bernd Küstner, Patrick Adam, Alexander Marx, Philipp Ströbel, Carsten Schmuck, Sebastian Schlücker,
Self-assembled monolayers (SAMs) of Raman reporter molecules adsorbed to the surface of metal nanoparticles are labelling agents for the selective detection of biomolecules by surface-enhanced Raman scattering (SERS). Advantages of SAM-based SERS labels include maximum coverage with Raman reporter molecules combined with their uniform molecular orientation within the SAM as well as minimal co-adsorption of other molecules from the surrounding. Water solubility and stability together with the option ...
Tópico(s): Biosensors and Analytical Detection
2009 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Bernd Küstner, Magdalena Gellner, Max Schütz, Friedrich Schöppler, Alexander Marx, Philipp Ströbel, Patrick Adam, Carsten Schmuck, Sebastian Schlücker,
Abstract In a glass house : Silica‐encapsulated self‐assembled monolayers (SAMs) on tunable gold/silver nanoshells were used as labels for surface‐enhanced Raman scattering (SERS). This concept combines the spectroscopic advantages arising from maximum surface coverage and uniform molecular orientation of the Raman reporter molecules within the complete monolayer together with the high chemical and mechanical stability of the glass shell. magnified image
Tópico(s): Quantum Dots Synthesis And Properties
2009 - Wiley | Angewandte Chemie International Edition
Hans‐Ullrich Völker, Andreas Zettl, Georg Schön, V. Heller, Elmar Heinrich, Andreas Rosenwald, M. Handwerker, Hans–Konrad Müller–Hermelink, Alexander Marx, Philipp Ströbel,
Tópico(s): Bladder and Urothelial Cancer Treatments
2008 - Springer Science+Business Media | Virchows Archiv
Andreas H. Marx, Philipp W. Simon, Ronald Simon, Martina Mirlacher, Jakob R. Izbicki, Emre F. Yekebas, Jussuf T. Kaifi, Luigi Terracciano, Guido Sauter,
Tópico(s): Cancer, Hypoxia, and Metabolism
2008 - Springer Science+Business Media | Virchows Archiv
Sebastian Schlücker, Bernd Küstner, A. Punge, R. Bonfig, Alexander Marx, Philipp Ströbel,
Abstract We demonstrate the first realization of immuno‐Raman microspectroscopy, a novel methodology in immunohistochemistry. The in situ detection of antigens in tissue specimens is achieved by surface‐enhanced Raman scattering (SERS) from aromatic Raman labels covalently linked to the corresponding antibody. As an example of applications of this new Raman technique, we present the localization of prostate‐specific antigen (PSA) in epithelial tissue from patients with prostate carcinoma (PCA). Copyright © ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2006 - Wiley | Journal of Raman Spectroscopy
Bernd Küstner, Magdalena Gellner, Max Schütz, Friedrich Schöppler, Alexander Marx, Philipp Ströbel, Patrick Adam, Carsten Schmuck, Sebastian Schlücker,
Abstract SAM im Glashaus : Glasverkapselte selbstorganisierte Monolagen (SAMs) auf durchstimmbaren Gold/Silber‐Nanoschalen wurden als Markierungsreagens für die oberflächenverstärkte Raman‐Streuung (SERS) eingesetzt. Dieses Konzept vereint die spektroskopischen Vorteile einer maximalen Oberflächenbedeckung und der einheitlichen molekularen Orientierung der Raman‐Markermoleküle innerhalb der vollständigen Monolage mit der hohen Stabilität einer Glashülle. magnified image
Tópico(s): Nonlinear Optical Materials Studies
2009 - Wiley | Angewandte Chemie