Bernd Saugel, Philipp Rakette, Alexander Hapfelmeier, Caroline Schultheiß, Veit Phillip, Philipp Thies, Matthias Treiber, Henrik Einwächter, Alexander von Werder, R. Pfab, Florian Eyer, Roland M. Schmid, Wolfgang Huber,
The purpose of this study was to evaluate prediction factors for extubation failure (need for reintubation within 48 hours) in medical intensive care unit patients.Sixty-one patients extubated after mechanical ventilation for more than 48 hours were included in the study. A retrospective analysis of medical records and a prospectively maintained database on respiratory parameters was conducted.Low serum anion gap (P = .001), low serum anion gap corrected for serum albumin (P = .010), and low arterial partial ...
Tópico(s): Family and Patient Care in Intensive Care Units
2012 - Elsevier BV | Journal of Critical Care
Philipp Veit, Carla Volkert, Christoph Förster, Vadim Ksenofontov, Steffen Schlicher, Matthias Bauer, Katja Heinze,
Gold(ii) species catalyse the cyclisation of N(2-propyn-1-yl)benzamide to 2-phenyl-5-vinylidene-2-oxazoline without halide abstraction while the saturated gold(i) complex is inactive. Redox-switching between gold(ii) and gold(i) turns catalytic turnover on and off.
Tópico(s): Organometallic Complex Synthesis and Catalysis
2019 - Royal Society of Chemistry | Chemical Communications
Martin Antosch, Veit Schubert, Philipp Holzinger, Andreas Houben, Klaus D. Grasser,
Summary The high mobility group ( HMG )‐box is a DNA ‐binding domain characteristic of various eukaryotic DNA ‐binding proteins. 3x HMG ‐box proteins (containing three copies of the HMG ‐box domain and a unique basic N‐terminal domain) are specific for plants and the A rabidopsis genome encodes two versions termed 3x HMG ‐box1 and 3x HMG ‐box2, whose expression is cell cycle‐dependent, peaking during mitosis. Here, we analysed in detail the spatiotemporal expression, subcellular localisation and chromosome ...
Tópico(s): Plant Molecular Biology Research
2015 - Wiley | New Phytologist
Christoph Förster, Philipp Veit, Vadim Ksenofontov, Katja Heinze,
The ultrastrong and short intramolecular NHFe hydrogen bond in diferrocenyl hydrazone raises the barrier for intramolecular electron transfer in its mixed-valent cation and is only disrupted by double oxidation to .
Tópico(s): N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
2014 - Royal Society of Chemistry | Chemical Communications
Caroline Schultheiß, Bernd Saugel, Veit Phillip, Philipp Thies, Sebastian Noé, Ulrich Mayr, Bernhard Haller, Henrik Einwächter, Roland M. Schmid, Wolfgang Huber,
Abstract Introduction Liver failure patients might be at risk for citrate accumulation during continuous venovenous hemodialysis (CVVHD) with regional citrate anticoagulation. The aim of this study was to investigate the predictive capability of baseline liver function parameters regarding citrate accumulation, expressed as an increase in the calcium total/calcium ionized (Ca tot /Ca ion ) ratio ≥2.5, and to describe the feasibility of citrate CVVHD in liver failure patients. Methods We conducted a prospective ...
Tópico(s): Dialysis and Renal Disease Management
2012 - BioMed Central | Critical Care
Anne Krüger, Marina Oldenburg, Chiranjeevi Chebrolu, Daniela Beißer, Julia Kolter, Anna M. Sigmund, Jörg Steinmann, Simon Schäfer, Hubertus Hochrein, Sven Rahmann, Hermann Wagner, Philipp Henneke, Veit Hornung, Jan Buer, Carsten J. Kirschning,
... Simon Schäfer4, Hubertus Hochrein5, Sven Rahmann2, Hermann Wagner6, Philipp Henneke3, Veit Hornung7, Jan Buer1 and Carsten J Kirschning 1 ...
Tópico(s): NF-κB Signaling Pathways
2015 - Springer Nature | EMBO Reports
Stijn M. Agten, Rory R. Koenen, Hans Ippel, Veit Eckardt, Philipp von Hundelshausen, Kevin H. Mayo, Christian Weber, Tilman M. Hackeng,
Abstract Protein–protein interactions (PPIs) govern most processes in living cells. Current drug development strategies are aimed at disrupting or stabilizing PPIs, which require a thorough understanding of PPI mechanisms. Examples of such PPIs are heteromeric chemokine interactions that are potentially involved in pathological disorders such as cancer, atherosclerosis, and HIV. It remains unclear whether this functional modulation is mediated by heterodimer formation or by the additive effects of ...
Tópico(s): Chemical Synthesis and Analysis
2016 - Wiley | Angewandte Chemie International Edition
Philipp Veit, Ephraim Prantl, Christoph Förster, Katja Heinze,
A strong nonclassical NH···Fe intramolecular hydrogen bond (IHB) is present in the literature-known diferrocenyl tosyl hydrazone (1). Here, we confirm by NMR and IR spectroscopy as well as by XRD methods that an analogous NH···Ru IHB is present in the heavier homologue diruthenocenyl tosyl hydrazone (2). The NH···Ru IHB in 2 is stronger than the NH···Fe IHB in 1 by 6 kJ mol–1, as determined by IR spectroscopy. Further, we probed the E/Z isomer directing abilities of NH···M IHBs in the synthesis of ...
Tópico(s): Metal complexes synthesis and properties
2016 - American Chemical Society | Organometallics
Philipp Veit, Christoph Förster, Sebastian Seibert, Katja Heinze,
Abstract Nucleophilic substitution of the ethoxy substituent in the Fischer carbene complex (ethoxy)(ferrocenyl)carbene(pentacarbonyl)chromium(0) ( 1 ) by ferrocenyl amide [Fc‐NH] – [2 ‐ H] – gives the hetero trimetallic complex (aminoferrocenyl)(ferrocenyl)carbene (pentacarbonyl)chromium(0) ( 3 ). As the Cr(CO) 5 fragment is isolobal to oxygen or sulfur 3 can be viewed as an isolobal metallo analogue to diferrocenylamide (Fc)(FcNH)C=O ( 4 ) and diferrocenylthioamide (Fc)(FcNH)C=S ( 5 ). The impact of the formal replacement of ...
Tópico(s): N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
2015 - Wiley | Zeitschrift für anorganische und allgemeine Chemie
Johannes Oberwinkler, Annette Lis, Klaus M. Giehl, Veit Flockerzi, Stephan Philipp,
TRPM3 is a poorly understood member of the large family of transient receptor potential (TRP) ion channels. Here we describe five novel splice variants of TRPM3, TRPM3alpha1-5. These variants are characterized by a previously unknown amino terminus of 61 residues. The differences between the five variants arise through splice events at three different sites. One of these splice sites might be located in the pore region of the channel as indicated by sequence alignment with other, better-characterized ...
Tópico(s): Plant Stress Responses and Tolerance
2005 - Elsevier BV | Journal of Biological Chemistry
Matthew T. Harper, Juan E. Camacho Londoño, Kathryn Quick, Julia Camacho Londoño, Veit Flockerzi, Stephan Philipp, Lutz Birnbaumer, Marc Freichel, Alastair W. Poole,
Platelets use the ion channels TRPC3 and TRPC6 to detect simultaneous exposure to two prothrombotic signals.
Tópico(s): Neurobiology and Insect Physiology Research
2013 - American Association for the Advancement of Science | Science Signaling
Thomas F.J. Wagner, Sabine Loch, Sachar Lambert, Isabelle Straub, Stefanie Mannebach, Ilka Mathar, Martina Düfer, Annette Lis, Veit Flockerzi, Stephan Philipp, Johannes Oberwinkler,
Tópico(s): Calcium signaling and nucleotide metabolism
2008 - Nature Portfolio | Nature Cell Biology
Andreas Beck, Claudia Fecher‐Trost, Karin Wolske, Stephan Philipp, Veit Flockerzi, Ulrich Wissenbach,
A screen to identify lysosomal‐expressed ion channels led to the discovery of the human Sidt2 protein. Sidt2 is expressed within lysosomal organelles but as a result of heterologous overexpression the protein is also detectable within the plasma membrane of human embryonic kidney cells. The overexpressed protein leads to cell depolarization upon sodium addition. Accordingly in whole‐cell patch clamp experiments a spontaneous noninactivating monovalent cation current can be detected in Sidt2‐overexpressing ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2016 - Wiley | FEBS Letters
Eva C. Schwarz, Ulrich Wissenbach, Barbara A. Niemeyer, Bettina Strauß, Stephan Philipp, Veit Flockerzi, Markus Hoth,
The Ca2+ homeostasis within cells controls a diversity of cellular processes including gene transcription, proliferation and apoptosis. Perturbance of Ca2+ signaling may induce deregulation of cell proliferation and suppression of cell death providing the basis for cancer development. In human prostate cancer, a correlation between the mRNA expression of the Ca2+ channel TRPV6 and the staging of the cancer has been described. We have analyzed the influence of TRPV6 on cell proliferation within HEK- ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2005 - Elsevier BV | Cell Calcium
Masahiro Kamouchi, Stephan Philipp, Veit Flockerzi, Ulrich Wissenbach, A G Mamin, Luc Raeymaekers, Jan Eggermont, G. Droogmans, Bernd Nilius,
1. We combined patch clamp and fura-2 fluorescence methods to characterize human TRP3 (hTRP3) channels heterologously expressed in cultured bovine pulmonary artery endothelial (CPAE) cells, which do not express the bovine trp3 isoform (btrp3) but express btrp1 and btrp4. 2. ATP, bradykinin and intracellular InsP3 activated a non-selective cation current (IhTRP3) in htrp3-transfected CPAE cells but not in non-transfected wild-type cells. During agonist stimulation, the sustained rise in [Ca2+]i was significantly ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1999 - Wiley | The Journal of Physiology
Ulrich Wissenbach, Gregor Schroth, Stephan Philipp, Veit Flockerzi,
Mammalian homologues of the transient receptor potential (trp) gene product from Drosophila melanogaster function as Ca 2+ ‐selective or non‐selective cation channels. Complementary DNA was isolated from a bovine testis cDNA library which encodes bovine trp2 (btrp2), a protein of 432 amino acid residues comprising four predicted transmembrane segments. Btrp2 mRNA is expressed in bovine testis, spleen and liver but not in brain, heart, adrenal gland or retina. In bovine testis expression of btrp2 mRNA ...
Tópico(s): Signaling Pathways in Disease
1998 - Wiley | FEBS Letters
Marc Freichel, Ulrich Wissenbach, Stephan Philipp, Veit Flockerzi,
In many non‐excitable as well as electrically excitable cells, depletion of intracellular Ca 2+ stores after stimulation of G protein coupled receptors or receptor tyrosine kinases is followed by Ca 2+ entry across the plasma membrane, a mechanism referred to as capacitative calcium entry (CCE) [Putney, J.W., Cell Calcium 11 (1990) 611–624; Fasolato, C. et al., Trends Pharmacol Sci. 15 (1994) 77–83]. Recently, we reported that bCCE 1, a homologue of the Drosophila protein trp , exhibits the characteristics ...
Tópico(s): Receptor Mechanisms and Signaling
1998 - Wiley | FEBS Letters
Stephan Philipp, Veit Flockerzi,
PDZ domains are thought to act as protein‐binding modules mediating the clustering of membrane and membrane‐associated proteins. The INAD protein has been shown to interact via a PDZ domain with the calcium channel TRP which contributes to capacitative calcium entry into Drosophila photoreceptor cells. We have cloned the cDNA of a human INAD‐Like protein (hINADL) of 1524 amino acids in length containing at least five PDZ domains. Additionally, two truncated versions hINADL Δ 304 and hINADL Δ 853 ...
Tópico(s): Cellular transport and secretion
1997 - Wiley | FEBS Letters
Philipp F. Veit, Hartmut Kircher,
Tópico(s): Nietzsche, Schopenhauer, and Hegel
1976 - Wiley | The German Quarterly
Veit Krenn, Philipp von Landenberg, Ewa Woźniak, C. Kißler, Hans K. Müller Hermelink, U. Zimmermannt, H. Peter Vollmers,
In this study, B-cells isolated from rheumatoid synovial tissue were immortalized, without prior in vitro stimulation, by means of electric-field induced fusion and conventional PEG fusion in order to compare the efficiency of these methods. Two myel
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1995 - IOS Press | Human Antibodies
Veit Eckardt, Christian Weber, Philipp von Hundelshausen,
Abstract Complex glycans are readily accessible on the endothelium and on cell and plasma components. They interact with glycan-binding proteins which translate their structure into function. Advanced analytical tools are available to investigate their structure and functional interactions. Modifications to glycan structures which alter their capacity to bind proteins are particularly relevant in atherosclerosis. We summarize the regulatory role of glycans and their binding partners in the development ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2019 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Alexander Krämer, Philipp Veit, Dominik K. Kanbach, Stephan Stubner, Thomas Maran,
Purpose The purpose of this article is to develop an integrative framework of accelerator design to answer the question of what activities accelerators perform and how they function within a structured framework. Research on the functioning of accelerators as a mechanism for startup engagement produced multiple empirical results. However, the comparability of relevant research is strongly limited, currently hindering theoretical developments. Existing accelerator design models often differ and only ...
Tópico(s): Entrepreneurship Studies and Influences
2023 - Emerald Publishing Limited | European Journal of Innovation Management
... for larger view View full resolution Figure 6. Philipp Veit. “Einführung der Künste durch das Christentum.” Städelsches Kunstinstitut, ...
1999 - Johns Hopkins University Press | MLN
R. Staehr, S. Bastick, S. Bluemel, Peter Jaeschke, Oliver Suttmann, Jan-Philipp Negel, Veit Angrick, Christian Stolzenburg, Stefan Kaierle, Ludger Overmeyer,
Due to their outstanding strength-to-weight ratio, carbon fiber reinforced plastics (CFRP) are of high interest for lightweight construction. Within industrial fields requiring lightweight design and energy efficiency, the demand for CFRP increases continuously. Until now, machining of CFRP, as a crucial step in the production chain of composite parts, is mainly performed by conventional techniques such as drilling, milling, and abrasive water jet cutting. These techniques come with known drawbacks, ...
Tópico(s): Advanced Surface Polishing Techniques
2019 - Laser Institute of America | Journal of Laser Applications
Bernd Saugel, Marisa Nowack, Alexander Hapfelmeier, Andreas Umgelter, Caroline Schultheiß, Philipp Thies, Veit Phillip, Florian Eyer, Roland M. Schmid, Wolfgang Huber,
The aim of this study was to evaluate continuous vancomycin infusion (contV) in intensive care unit patients. A retrospective study in 164 patients treated with contV was conducted. They were compared with 75 patients treated with intermittent vancomycin infusion. The median duration of vancomycin therapy in the contV group was 6 (5%-95% percentile range, 2-21) days. The median daily vancomycin dose in the contV group was 960 (526-1723) mg, resulting in a median serum vancomycin plateau concentration ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2012 - Elsevier BV | Journal of Critical Care
Veit Krenn, H. Peter Vollmers, Philipp von Landenberg, Bernd Schmaußer, H. K. Müller-Hermelink, Martina Rupp, Andreas Roggenkamp,
Tópico(s): Vector-borne infectious diseases
1996 - Springer Science+Business Media | Virchows Archiv
Alexander Becker, Barbara Wardas, Houssein Salah, Maryam Amini, Claudia Fecher‐Trost, Sen Qiao, Damian Martus, Andreas Beck, Stephan Philipp, Veit Flockerzi, Anouar Belkacemi,
Voltage-gated Ca2+ (Cav) channels consist of a pore-forming Cavα1 subunit and auxiliary Cavα2-δ and Cavβ subunits. In fibroblasts, Cavβ3, independent of its role as a Cav subunit, reduces the sensitivity to low concentrations of inositol-1,4,5-trisphosphate (IP3). Similarly, Cavβ3 could affect cytosolic calcium concentration ([Ca2+]) in pancreatic β-cells. In this study, we deleted the Cavβ3-encoding gene Cacnb3 in insulin-secreting rat β-(Ins-1) cells using CRISPR/Cas9. These cells were used as controls ...
Tópico(s): Pancreatic function and diabetes
2021 - American Diabetes Association | Diabetes
Philipp Veit, Christoph Förster, Katja Heinze,
(Aminoferrocenyl)(ferrocenyl)carbene(pentacarbonyl)tungsten(0) (CO) 5 W=C(NHFc)Fc ( W(CO) 5 ( E -2) ) is synthesized by nucleophilic substitution of the ethoxy group of (CO) 5 W=C(OEt)Fc ( M(CO) 5 (1 Et ) ) by ferrocenyl amide Fc-NH – (Fc = ferrocenyl). W(CO) 5 ( E -2) thermally and photochemically eliminates bulky E -1,2-diferrocenylimine ( E -3 ) via a formal 1,2-H shift from the N to the carbene C atom. Kinetic and mechanistic studies to the formation of imine E -3 are performed by NMR, IR and UV–vis spectroscopy and liquid ...
Tópico(s): N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
2016 - Beilstein Institute for the Advancement of Chemical Sciences | Beilstein Journal of Organic Chemistry
Kai Rejeski, Wolfgang G. Kunz, Martina Rudelius, Veit Bücklein, Viktoria Blumenberg, Christian Schmidt, Philipp Karschnia, Florian Schöberl, Konstantin Dimitriadis, Louisa von Baumgarten, Hans‐Joachim Stemmler, Oliver Weigert, Martin Dreyling, Michael von Bergwelt‐Baildon, Marion Subklewe,
Abstract Background Prolonged myelosuppression following CD19-directed CAR T-cell transfusion represents an important, yet underreported, adverse event. The resulting neutropenia and multifactorial immunosuppression can facilitate severe infectious complications. Case presentation We describe the clinical course of a 59-year-old patient with relapsed/refractory DLBCL who received Axicabtagene-Ciloleucel (Axi-cel). The patient developed ASTCT grade I CRS and grade IV ICANS, necessitating admission ...
Tópico(s): Fungal Infections and Studies
2021 - BioMed Central | BMC Infectious Diseases
Lars Husmann, B. A. Herzog, Oliver Gaemperli, Fuminari Tatsugami, N. Burkhard, Ines Valenta, Patrick Veit‐Haibach, C. Wyss, Ulf Landmesser, Philipp A. Kaufmann,
AimsTo determine diagnostic accuracy, effective radiation dose, and potential value of computed tomography coronary angiography (CTCA) for hybrid imaging with single-photon emission computed tomography (SPECT) comparing prospective electrocardiogram (ECG)-triggering vs. retrospective ECG-gating.
Tópico(s): Advanced X-ray and CT Imaging
2008 - Oxford University Press | European Heart Journal