Caroline Conran, Michael Moynahan, Derby Tip, Alex Finer, Richard Buckle, John Fryer, K Hussain, Adrian A Enfiezioglon, Rob Hughes, John Peter, Edmund Crispin, John Lambert, Kenneth Pearson, James Poole, Graham Rose, Ross Calvert, David Steel, Stanley Reynolds, Harold Lever, Julian Symons, lan Nairn, Richard Streeton, Henry Brandon, Nicholas Taylor, John Russell, Richard Milner, Nora Beloff, Egremont, Edgar Snow, Philip Clarke, Derek Jewell, John Lindsay, Vivian Jenkins, Murray Sayle, John Ballantine, Norman Harris, Henry V. Dicks, Peter Durisch, Robert Ray, Sheila McNeil, Robin Marlar, Dan van der Vat, Hugh Somerville, Thomas Hickman, Cyril Connolly, Brian Moynahan, Alexander Shihwarg, Peter Lennon, Phillip Knightly, John Ball, Boris Schapiro, Robert Blake, Maxwell Boyd, Molly Parkin, Nicholas Evans, Oscar Turnill, David Holbrook, Peter Wilsher, Aziz Khan-Panni, Roger Mortimer, Malcolm Winton, John Raymond, Ernestine Carter, William G Swain, David Blake, Desmond Shawe-Taylor, Kenneth Tynan, Alan Brien, Gwen Nuttall, Michael Bateman, Stephen Aris, Hasan Rabbl, Patrick Rowley, Jean Robertson, Dilys Powell, Margaret Beddoes, Geoffrey Pollitt, Elkan Allan, Tony Osman, Heenan Beddow, Dudley Doust, Felix Aprahamian, Ian Nairn, J W Lambert, Henry Longhurst, Dick Taverne Qc, Mp, Lewis Chester, Susan Raven, John Allard, Peter Pringle, Frank Dunlop, James Margach Political Correspondent, W. G. Gross, Hunter Davies, Derek Humphry, Michael Moynihan, Brian Glanville, David Williams, Keith Richardson, Laming Roper, Graham Searjeant, C. H. O'd. Alexander, Michael Deacon, Nicholas Faith, Michael Parkinson, Asa Briggs, Robert Yoakum, Allan Hall, Brenda Jones, Philip Jacobson, Vincent Hanna, Muriel Bowen, Nicholas Tomalin,
... Golf Bartlett Recruitment Services Team (Management Appointments) Limited Coutinho, Caro and Co. Ltd. Multiple Display Advertising Items ... In my Fashion Imperial Cancer Research Fund Baroness Philippe De Rothschild by Yues Saint… Your Most Beautiful ...
1971 - Gale Group | Sunday Times HA GDA
J. A. Van Gisbergen, David A. Robinson, Stan Gielen,
... position error explains saccadic decisions during pursuitJonathan D. Coutinho, Philippe Lefèvre, and Gunnar Blohm10 March 2021 | Journal of ...
Tópico(s): Vestibular and auditory disorders
1981 - American Physiological Society | Journal of Neurophysiology
K. Afifi, Guillaume Bellanger, Pieter-Jan Buyck, Susanna M. Zuurbier, Carlos García Esperón, Miguel A. Barboza, Paolo Costa, Irene Escudero‐Martínez, Dimitri Renard, Robin Lemmens, Nicole Hinteregger, Franz Fazekas, Jordi Jiménez Conde, Eva Giralt‐Steinhauer, Sini Hiltunen, Antonio Araúz, Alessandro Pezzini, Joan Montaner, Jukka Putaala, Christian Weimar, Marc Schlamann, Thomas Gattringer, Turgut Tatlisumak, Jonathan M. Coutinho, Philippe Demaerel, Vincent Thijs,
Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage. To identify clinical and imaging features of CVT-associated intracranial hemorrhage. We hypothesized that higher clot burden would be associated with a higher risk of intracranial hemorrhage. We performed a retrospective analysis of an international, multicenter cohort of patients with confirmed cerebral venous thrombosis who underwent computed tomography within 2 weeks of symptom onset. Clinical and imaging features were ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2020 - Springer Science+Business Media | Journal of Neurology
Pieter-Jan Buyck, Susanna M. Zuurbier, Carlos García-Esperón, Miguel A. Barboza, Paolo Costa, Irene Escudero‐Martínez, Dimitri Renard, Robin Lemmens, Nicole Hinteregger, Franz Fazekas, Jordi Jiménez Conde, Eva Giralt‐Steinhauer, Sini Hiltunen, Antonio Araúz, Alessandro Pezzini, Joan Montaner, Jukka Putaala, Christian Weimar, Leonid Churilov, Thomas Gattringer, Hamed Asadi, Turgut Tatlisumak, Jonathan M. Coutinho, Philippe Demaerel, Vincent Thijs,
Objective To assess the added diagnostic value of semiquantitative imaging markers on noncontrast CT scans in cerebral venous thrombosis (CVT). Methods In a retrospective, multicenter, blinded, case-control study of patients with recent onset (<2 weeks) CVT, 3 readers assessed (1) the accuracy of the visual impression of CVT based on a combination of direct and indirect signs, (2) the accuracy of attenuation values of the venous sinuses in Hounsfield units (with adjustment for hematocrit levels), and (3) the accuracy ...
Tópico(s): Acute Ischemic Stroke Management
2019 - Lippincott Williams & Wilkins | Neurology
Produção Nacional
Revisado por pares
Artur Martins Coutinho, Jean‐Philippe Coutu, Emily Lindemer, H. Diana Rosas, Bruce R. Rosen, David H. Salat,
Aside from cortical damage associated with age, cerebrovascular and neurodegenerative diseases, it's an outstanding question if factors of global health, including normal variation in blood markers of metabolic and systemic function, may also be associated with individual variation in brain structure. This cross-sectional study included 138 individuals between 40 to 86 years old who were physically healthy and cognitively intact. Eleven markers (total cholesterol, HDL, LDL, triglycerides, insulin, ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2016 - Elsevier BV | NeuroImage
Cyril Goizet, A. Boukhris, A. Dürr, Christian Beetz, Jérémy Truchetto, Christelle Tesson, Maria K. Tsaousidou, Sylvie Forlani, Lucie Guyant‐Maréchal, B. Fontaine, João Tiago Guimarães, Bertrand Isidor, O. Chazouillères, Dominique Wendum, Djamel Grid, Françoise Chevy, Patrick F. Chinnery, Paula Coutinho, Jean‐Philippe Azulay, Imed Feki, Fanny Mochel, Claude Wolf, Chokri Mhiri, Andrew H. Crosby, Alexis Brice, Giovanni Stévanin,
Thirty-four different loci for hereditary spastic paraplegias have been mapped, and 16 responsible genes have been identified. Autosomal recessive forms of spastic paraplegias usually have clinically complex phenotypes but the SPG5, SPG24 and SPG28 loci are considered to be associated with 'pure' forms of the disease. Very recently, five mutations in the CYP7B1 gene, encoding a cytochrome P450 oxysterol 7-α hydroxylase and expressed in brain and liver, have been found in SPG5 families. We analysed ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2009 - Oxford University Press | Brain
G C Coutinho, Sylvie Delassusu, Philippe Kourilskyu, António Bandeira, António Coutinho,
Abstract In mice, immunological tolerance to self is established in the perinatal period, when tolerance susceptibility to allogenic tissues is higher than in adults. We have now investigated whether this could result from developmental regulation of effector functions of T cells exposed to specific antigens, by studying the “natural” or T cell receptor‐induced expression of several interleukin genes. We used qualitative and quantitative polymerase chain reaction methods to study interleukin (IL)‐ ...
Tópico(s): Reproductive System and Pregnancy
1994 - Wiley | European Journal of Immunology
Produção Nacional
Revisado por pares
Jeffer Eidi Sasaki, Andrée Philippe Pimentel Coutinho, Carla Menêses Hardman, Cecília Bertuol, Giseli Minatto, Juliane Berria, Lúcia Midori Damaceno Tonosaki, Luiz Rodrigo Augustemak de Lima, Moane Marchesan, Pablo Magno da Silveira, Rodrigo de Rosso Krug, Tânia Rosane Bertoldo Benedetti,
O objetivo do presente estudo foi apresentar um conjunto de orientações para a utilização de acelerômetros no Brasil. O método consistiu na revisão e síntese de artigos que utilizaram acelerômetros como instrumento de medida objetiva da atividade física. Com base nesses estudos, buscou-se apresentar orientações para as fases pré-coleta (seleção do acelerômetro; testagem da calibração dos acelerômetros, atualização de firmware; estudo piloto; e definição de protocolo), coleta (distribuição dos acelerômetros; ...
Tópico(s): Physical Education and Gymnastics
2017 - Sociedade Brasileira de Atividade Física & Saúde | Revista Brasileira de Atividade Física & Saúde
Jian Xu, Michael A. Mahowald, Ruth E. Ley, Catherine Lozupone, Micah Hamady, Eric C. Martens, Bernard Henrissat, Pedro M. Coutinho, Patrick Minx, Philippe Latreille, Holland S. Cordum, Andrew Van Brunt, Kyung Kim, Robert S. Fulton, Lucinda A. Fulton, Sandra W. Clifton, Richard K. Wilson, Rob Knight, Jeffrey I. Gordon,
The adult human intestine contains trillions of bacteria, representing hundreds of species and thousands of subspecies. Little is known about the selective pressures that have shaped and are shaping this community's component species, which are dominated by members of the Bacteroidetes and Firmicutes divisions. To examine how the intestinal environment affects microbial genome evolution, we have sequenced the genomes of two members of the normal distal human gut microbiota, Bacteroides vulgatus ...
Tópico(s): Probiotics and Fermented Foods
2007 - Public Library of Science | PLoS Biology
Produção Nacional
Revisado por pares
Marianna Ribeiro de Menezes Freire, Philippe Mota Coutinho da Silva, Arthur Rangel Azevedo, Denison Santos Silva, Ronald Bispo Barreto da Silva, Juliana Cordeiro Cardoso,
This study aimed to analyze the efficacy of platelet-rich plasma obtained from the peripheral, autologous blood of the patients in pain complaints reduction and functional improvement of knee osteoarthritis compared with the standard treatment with injectable corticosteroid, such as triamcinolone.
Tópico(s): Sexual function and dysfunction studies
2018 - Thieme Medical Publishers (Germany) | Revista Brasileira de Ortopedia
Sylvie Delassus, G C Coutinho, Caroline Saucier, Sylvie Darche, Philippe Kourilsky,
Abstract To evaluate the influence of gestation on peripheral blood T cells, we measured the mRNA production of several cytokines (IL-2, IL-4, IL-10, IFN-gamma) and the p55 subunit of IL-2R at different time points in the blood of pregnant mice and in the placenta. This was made possible by the use of a new PCR technique that is precise and quantitative. Our results show that pregnancy induces profound changes in the expression of these genes in peripheral blood cells. During the first week of gestation, ...
Tópico(s): Pregnancy and preeclampsia studies
1994 - American Association of Immunologists | The Journal of Immunology
Jorge Sequeiros, Isabel Silveira, Patrı́cia Maciel, Paula Coutinho, Alexandra Manaia, Cláudia Gaspar, Philippe Burlet, José L. Loureiro, Joao C. Guimaraes, Hajime Tanaka, Yoshihisa Takiyama, H. Sakamoto, Masatoyo Nishizawa, Yoshiko Nomura, Masaya Segawa, Shoji Tsuji, Judith Melki, Arnold Münnich,
Machado-Joseph disease (MJD) is a dominant multisystem degeneration found mostly among Azoreans and characterized by the adulthood onset of cerebellar, ocular, pyramidal, extrapyramidal, and/or peripheral signs. MJD has been recorded in many other populations, particularly in the United States and Japan. Using the microsatellite DNA polymorphisms (STRPs) D14S53, D14S55, D14S48, and D14S45, we found significantly positive lod scores in 16 Portuguese kindreds, suggesting that the MJD locus is linked ...
Tópico(s): Lysosomal Storage Disorders Research
1994 - Elsevier BV | Genomics
Omri Nachmani, Jonathan Coutinho, Aarlenne Z. Khan, Philippe Lefèvre, Gunnar Blohm,
Abstract For humans, visual tracking of moving stimuli often triggers catch-up saccades during smooth pursuit. The switch between these continuous and discrete eye movements is a trade-off between tolerating sustained position error (PE) when no saccade is triggered or a transient loss of vision during the saccade due to saccadic suppression. de Brouwer et al. (2002b) demonstrated that catch-up saccades were less likely to occur when the target re-crosses the fovea within 40–180 ms. To date, there ...
Tópico(s): Motor Control and Adaptation
2019 - Society for Neuroscience | eNeuro
Jonathan Coutinho, Philippe Lefèvre, Gunnar Blohm,
A fundamental problem in motor control is the coordination of complementary movement types to achieve a common goal. As a common example, humans view moving objects through coordinated pursuit and saccadic eye movements. Pursuit is initiated and continuously controlled by retinal image velocity. During pursuit, eye position may lag behind the target. This can be compensated by the discrete execution of a catch-up saccade. The decision to trigger a saccade is influenced by both position and velocity ...
Tópico(s): Neural dynamics and brain function
2020 - American Physiological Society | Journal of Neurophysiology
Buck S. Samuel, Elizabeth E. Hansen, Jill K. Manchester, Pedro M. Coutinho, Bernard Henrissat, R. A. Fulton, Philippe Latreille, Kung Kim, Richard K. Wilson, Jeffrey I. Gordon,
The human gut is home to trillions of microbes, thousands of bacterial phylotypes, as well as hydrogen-consuming methanogenic archaea. Studies in gnotobiotic mice indicate that Methanobrevibacter smithii , the dominant archaeon in the human gut ecosystem, affects the specificity and efficiency of bacterial digestion of dietary polysaccharides, thereby influencing host calorie harvest and adiposity. Metagenomic studies of the gut microbial communities of genetically obese mice and their lean littermates ...
Tópico(s): Epigenetics and DNA Methylation
2007 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Produção Nacional
Revisado por pares
Marianna Ribeiro de Menezes Freire, Philippe Mota Coutinho da Silva, Arthur Rangel Azevedo, Denison Santos Silva, Ronald Bispo Barreto da Silva, Juliana Cordeiro Cardoso,
Resumo Objetivo Analisar a eficácia do uso de plasma rico em plaquetas, obtido do sangue periférico e autólogo dos pacientes, na redução das queixas álgicas e melhoria funcional dos pacientes portadores de osteoartrite de joelhos, em comparação com o tratamento padrão com injeção de corticosteroides de depósito, como a triancilonola. Métodos Os pacientes foram acompanhados clinicamente na consulta pré-infiltrativa, com avaliação quantitativa através das escalas Knee Society Score (KSS), Western Ontario ...
Tópico(s): Tendon Structure and Treatment
2020 - Thieme Medical Publishers (Germany) | Revista Brasileira de Ortopedia
Produção Nacional
Revisado por pares
Robson Coutinho‐Silva, Lynn Stahl, Marie-Noëlle Raymond, Thomas Jungas, Philippe Verbeke, Geoffrey Burnstock, Toni Darville, David M. Ojcius,
Abstract Chlamydia trachomatis survives within host cells by inhibiting fusion between Chlamydia vacuoles and lysosomes. We show here that treatment of infected macrophages with ATP leads to killing of chlamydiae through ligation of the purinergic receptor, P2X 7 R. Chlamydial killing required phospholipase D (PLD) activation, as PLD inhibition led to rescue of chlamydiae in ATP-treated macrophages. However, there was no PLD activation nor chlamydial killing in ATP-treated P2X 7 R-deficient macrophages. ...
Tópico(s): Adolescent and Pediatric Healthcare
2003 - Cell Press | Immunity
Gilles De Luca, Mohamed Barakat, Philippe Ortet, Sylvain Fochesato, Cécile Jourlin‐Castelli, Mireille Ansaldi, Béatrice Py, Gwennaële Fichant, Pedro M. Coutinho, Romé Voulhoux, Olivier Bastien, Éric Maréchal, Bernard Henrissat, Yves Quentin, Philippe Noirot, Alain Filloux, Vincent Méjean, Michael S. DuBow, Frédéric Barras, Valérie Barbe, Jean Weissenbach, I. Mihalcescu, André Verméglio, Wafa Achouak, Thierry Heulin,
Ramlibacter tataouinensis TTB310T (strain TTB310), a betaproteobacterium isolated from a semi-arid region of South Tunisia (Tataouine), is characterized by the presence of both spherical and rod-shaped cells in pure culture. Cell division of strain TTB310 occurs by the binary fission of spherical "cyst-like" cells ("cyst-cyst" division). The rod-shaped cells formed at the periphery of a colony (consisting mainly of cysts) are highly motile and colonize a new environment, where they form a new colony by ...
Tópico(s): Protist diversity and phylogeny
2011 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Alfonso Allen‐Perkins, Ainhoa Magrach, Matteo Dainese, Lucas A. Garibaldi, David Kleijn, Romina Rader, James R. Reilly, Rachael Winfree, Ola Lundin, C. M. McGrady, Claire Brittain, David J. Biddinger, Derek R. Artz, Elizabeth Elle, George D. Hoffman, Jamie Ellis, Jaret C. Daniels, Jason Gibbs, Joshua W. Campbell, Julia Brokaw, Julianna K. Wilson, Keith S. Mason, Kimiora L. Ward, K. B. Gundersen, Kyle Bobiwash, Larry J. Gut, Logan Rowe, Natalie K. Boyle, Neal M. Williams, Neelendra K. Joshi, Nikki L. Rothwell, Robert L. Gillespie, Rufus Isaacs, Shelby J. Fleischer, Stephen Peterson, Sujaya Rao, Theresa L. Pitts‐Singer, Thijs P. M. Fijen, Virginie Boreux, Maj Rundlöf, Blandina Felipe Viana, Alexandra‐Maria Klein, Henrik G. Smith, Riccardo Bommarco, Luísa G. Carvalheiro, Taylor H. Ricketts, Jaboury Ghazoul, Smitha Krishnan, Faye Benjamin, João Loureiro, Sílvia Castro, Nigel E. Raine, G.A. de Groot, Finbarr G. Horgan, Juliana Hipólito, Guy Smagghe, Ivan Meeus, Maxime Eeraerts, Simon G. Potts, Claire Kremen, Daniel Garcı́a, Marcos Miñarro, David W. Crowder, Gideon Pisanty, Yael Mandelik, Nicolas J. Vereecken, Nicolas Leclercq, Timothy Weekers, Sandra Lindström, Dara A. Stanley, Carlos Zaragoza‐Trello, Charlie Nicholson, Jeroen Scheper, Carlos Rad, Evan A.N. Marks, Lucie Mota, Bryan N. Danforth, Mia Park, Antônio Diego M. Bezerra, Breno Magalhães Freitas, Rachel E. Mallinger, Fabiana Oliveira da Silva, Bryony K. Willcox, Davi de Lacerda Ramos, Felipe Deodato da Silva e Silva, Amparo Lázaro, David Alomar, Miguel A. González‐Estévez, Hisatomo Taki, Daniel P. Cariveau, Michael P. D. Garratt, Diego N. Nabaes Jodar, Rebecca Stewart, Daniel Ariza, Matti Pisman, Elinor M. Lichtenberg, Christof Schüepp, Félix Herzog, Martin H. Entling, Yoko L. Dupont, Charles D. Michener, Gretchen C. Daily, Paul R. Ehrlich, Katherine L. W. Burns, Montserrat Vilà, Andrew Robson, Brad G. Howlett, Leah Blechschmidt, Frank Jauker, Franziska Schwarzbach, Maike Nesper, Tim Diekötter, Volkmar Wolters, Helena Castro, Hugo Gaspar, Brian A. Nault, Isabelle Badenhausser, Jessica D. Petersen, Teja Tscharntke, Vincent Bretagnolle, D. Susan Willis Chan, Natacha P. Chacoff, Georg K.S. Andersson, Shalene Jha, Jonathan F. Colville, Ruan Veldtman, Jeferson G. E. Coutinho, Felix J.J.A. Bianchi, Louis Sutter, Matthias Albrecht, Philippe Jeanneret, Yi Zou, Anne L. Averill, Agustín Sáez, Amber R. Sciligo, Carlos Vergara, Elias H. Bloom, Elisabeth Oeller, Ernesto I. Badano, Gregory M. Loeb, Heather Grab, Johan Ekroos, Vesna Gagić, Saul A. Cunningham, Jens Åström, Pablo Cavigliasso, Alejandro Trillo, Alice Claßen, Alice L. Mauchline, Ana Montero‐Castaño, Andrew Wilby, Ben A. Woodcock, C. Sheena Sidhu, Ingolf Steffan‐Dewenter, Ioannis Ν. Vogiatzakis, José M. Herrera, Mark Otieno, Mary Gikungu, Sarah Cusser, Thomas Nauß, L. Anders Nilsson, Jessica Knapp, Jorge J. Ortega‐Marcos, José A. González, Juliet L. Osborne, Rosalind Blanche, Rosalind F. Shaw, Violeta Hevia, Jane C. Stout, Anthony D. Arthur, Betina Blochtein, Hajnalka Szentgyörgyi, Jin Li, Margaret M. Mayfield, Michał Woyciechowski, Patrícia Nunes‐Silva, Rosana Halinski, Steve Henry, Benno I. Simmons, Bo Dalsgaard, Katrine Hartung Hansen, Tuanjit Sritongchuay, Alison D. O'Reilly, Fermín J. Chamorro, Guiomar Nates Parra, Camila Magalhães Pigozzo, Ígnasi Bartomeus,
Abstract Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this service, develop predictions, and inform management actions. Here, we present CropPol, a dynamic, ...
Tópico(s): Insect-Plant Interactions and Control
2021 - Wiley | Ecology
Produção Nacional
Revisado por pares
Diego Augustus Senna, Victor Rezende Moreira, Míriam Cristina Santos Amaral, Eduardo Coutinho de Paula, Luiz Philippe Pereira, Ramon Matheus Guimarães Batista, Luis Augusto Figueiredo Ferreira, Sonaly Rezende,
Access to safe water is still a challenge. Millions of people worldwide, mainly in rural and remote regions, still do not have access to safe drinking water. Point-of-use and decentralized water treatment systems have the potential to improve their livelihood, especially if these technologies are combined with the advantages brought by the Fourth Industrial Revolution. This paper presents and discusses opportunities for convergence between water treatment mainly using membrane separation processes ...
Tópico(s): IoT and Edge/Fog Computing
2023 - Elsevier BV | Journal of environmental chemical engineering
Philippe Galinier, Zied Boujbel, Michael Coutinho Fernandes,
Tópico(s): Constraint Satisfaction and Optimization
2011 - Springer Science+Business Media | Annals of Operations Research
Philippe Jean‐Baptiste, P. Allard, Rui Coutinho, Teresa Ferreira, Élise Fourré, G. Queiroz, J. L. Gaspar,
We present the first helium isotope data for thermal waters and gas emissions on the islands of Terceira, Graciosa, Faial, Pico and Flores, as well as new data for Sao Miguel. The results allow us to track current mantle degassing associated with the Azores hot spot, to delineate its spatial distribution and to discuss its possible origin. As a general rule, we find that free gases tend to display somewhat higher 3He/4He ratio than groundwaters. We argue that this difference is likely due to radiogenic ...
Tópico(s): High-pressure geophysics and materials
2009 - Elsevier BV | Earth and Planetary Science Letters
Produção Nacional
Revisado por pares
Patrícia Duarte Deps, Hugo Pessotti Aborghetti, Taís Loureiro Zambon, Victória Coutinho Costa, Julienne Dadalto dos Santos, Simon M. Collin, Philippe Charlier,
It is important for dermatologists and other physicians in refugee-receiving countries to acquire knowledge of forensic dermatology to identify lesions from torture.Review forensic dermatology in cases of torture.In provision of medical assessment and care to refugees and migrants, chronic skin lesions will be the most readily identifiable signs of torture. Beatings are common, with blunt force trauma resulting in postinflammatory hyperpigmentation. Torture burns can be thermal, chemical, or electrothermal, ...
Tópico(s): Genital Health and Disease
2020 - Elsevier BV | Journal of the American Academy of Dermatology
Produção Nacional
Revisado por pares
Philippe Bogaerts, D. Coutinho,
This paper proposes a robust nonlinear observer for bioreactors combining the classical asymptotic observer and a nonlinear Luenberger-like observer. The resulting hybrid observer considers a new definition of the hybridization parameter which reflects the kinetic model confidence. The nonlinear observer is tuned on the basis of robust H-infinity approach and the differential-algebraic representation (DAR) of nonlinear systems. A simulated case study concerning fed-batch animal cell cultures is presented ...
Tópico(s): Control Systems and Identification
2013 - Elsevier BV | Computers & Chemical Engineering
Anya F. Bouarab, Mónia A. R. Martins, Olga Stolarska, Marcin Śmiglak, Jean‐Philippe Harvey, João A. P. Coutinho, Christian Robelin,
Mixing ionic liquids is a simple and economical method of exploiting their tunability and allows to use ionic liquids with high melting temperatures for low-temperature applications through the formation of eutectic mixtures. In this study, the phase diagrams of the [C4mpy][PF6]-[C4mpip][PF6]-[C4mpyrr][PF6] ternary system (where [C4mpyrr] = 1-butyl-1-methylpyrrolidinium; [C4mpy] = 1-butyl-3-methylpyridinium; [C4mpip] = 1-butyl-1-methyl-piperidinium) and all of its unary and binary subsystems were measured ...
Tópico(s): Extraction and Separation Processes
2020 - Elsevier BV | Journal of Molecular Liquids
Rita Calé, Filipa Ferreira, Ana Rita Pereira, C Saraiva, Ana Coutinho Santos, Sofia Alegria, Débora Repolho, Rui Vitorino, Pedro Santos, Gonçalo Morgado, Philippe Brénot, María José Loureiro, Hélder Pereira,
Balloon pulmonary angioplasty (BPA) has emerged as a promising therapeutic option for patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are not eligible for pulmonary thromboendarterectomy (PEA) or who have recurrent or persistent pulmonary hypertension after surgery. There is no standardized technique for BPA and, its complexity and high risk of severe complications, requires skills and appropriate training and should be reserved for expert CTEPH centers, as a complementary intervention ...
Tópico(s): Cardiovascular Function and Risk Factors
2021 - Elsevier BV | Revista Portuguesa de Cardiologia
... rather than the revenue.Costly purchase player, namely Philippe Coutinho, is not worth the high paid amount and ...
Tópico(s): Fiscal Policies and Political Economy
2022 - Atlantis Press | Advances in economics, business and management research/Advances in Economics, Business and Management Research
Eric Espagne, Olivier Lespinet, Fabienne Malagnac, Corinne Da Silva, Olivier Jaillon, Betina M. Porcel, Arnaud Couloux, Jean‐Marc Aury, Béatrice Segurens, Julie Poulain, Véronique Anthouard, Sandrine Grossetête, Hamid Khalili, Evelyne Coppin, Michelle Déquard-Chablat, Marguerite Picard, Véronique Contamine, Sylvie Arnaise, A Bourdais, Véronique Berteaux‐Lecellier, Daniel Gautheret, Ronald P. de Vries, Evy Battaglia, Pedro M. Coutinho, Étienne Danchin, Bernard Henrissat, Riyad El Khoury, Annie Sainsard‐Chanet, Antoine Boivin, Bérangère Pinan‐Lucarré, Carole H. Sellem, Robert Debuchy, Patrick Wincker, Jean Weissenbach, Philippe Silar,
Abstract Background The dung-inhabiting ascomycete fungus Podospora anserina is a model used to study various aspects of eukaryotic and fungal biology, such as ageing, prions and sexual development. Results We present a 10X draft sequence of P. anserina genome, linked to the sequences of a large expressed sequence tag collection. Similar to higher eukaryotes, the P. anserina transcription/splicing machinery generates numerous non-conventional transcripts. Comparison of the P. anserina genome and ...
Tópico(s): Plant-Microbe Interactions and Immunity
2008 - BioMed Central | Genome biology
Vydianathan Ravi, Shipra Bhatia, Philippe Gautier, Felix Loosli, Boon-Hui Tay, Alice Tay, Emma Murdoch, Pedro M. Coutinho, Veronica van Heyningen, Sydney Brenner, Byrappa Venkatesh, Dirk A. Kleinjan,
Pax6 is a developmental control gene essential for eye development throughout the animal kingdom. In addition, Pax6 plays key roles in other parts of the CNS, olfactory system, and pancreas. In mammals a single Pax6 gene encoding multiple isoforms delivers these pleiotropic functions. Here we provide evidence that the genomes of many other vertebrate species contain multiple Pax6 loci. We sequenced Pax6-containing BACs from the cartilaginous elephant shark (Callorhinchus milii) and found two distinct ...
Tópico(s): Animal Genetics and Reproduction
2013 - Public Library of Science | PLoS Genetics
Daniela Lopes, Catarina Pereira‐Leite, Philippe Fontaine, Ana Coutinho, Manuel Prieto, Bruno Sarmento, Sven Jakobtorweihen, Cláudia Nunes, Salette Reis,
Omeprazole is usually administered under an enteric coating. However, there is a Food and Drug Administration-approved strategy that enables its release in the stomach. When locally absorbed, omeprazole shows a higher efficacy and a cytoprotective effect, whose mechanism was still unknown. Therefore, we aimed to assess the effect of the absorption route on the gastric mucosa. 2D and 3D models of dipalmitoylphosphatidylcholine (DPPC) at different pH values (5.0 and 7.4) were used to mimic different ...
Tópico(s): Drug Transport and Resistance Mechanisms
2021 - American Chemical Society | Journal of Medicinal Chemistry