Nicolas Arlicot, Johnny Vercouillie, Maria-Joao Santiago Ribeiro, Clovis Tauber, Y. Venel, Jean‐Louis Baulieu, Serge Maïa, Philippe Corcia, Michael G. Stabin, Aaron J. Reynolds, Michael Kassiou, Denis Guilloteau,
The translocator protein 18 kDa (TSPO), although minimally expressed in healthy brain, is up-regulated in pathological conditions, coinciding with microglial activation. It is thereby a suitable in vivo biomarker of neuroinflammation for detection, evaluation and therapeutic monitoring of brain diseases. We aimed to estimate the radiation dosimetry of the positron emission tomography (PET) TSPO radioligand [(18)F]DPA-714, and we evaluated in healthy volunteers its whole-body uptake and cerebral kinetics. ...
Tópico(s): Medical Imaging Techniques and Applications
2011 - Elsevier BV | Nuclear Medicine and Biology
Elia d’Acremont, Sylvie Leroy, Marcia Maïa, Philippe Patriat, Marie‐Odile Beslier, Nicolas Bellahsen, Marc Fournier, Pascal Gente,
Magnetic and gravity data gathered during the Encens-Sheba cruise (2000 June) in the eastern Gulf of Aden provide insights on the structural evolution of segmentation from rifted margins to incipient seafloor spreading. In this study, we document the conjugate margins asymmetry, confirm the location of the ocean–continent transition (OCT) previously proposed by seismic data, and describe its deep structure and segmentation. In the OCT, gravity models indicate highly thinned crust while magnetic data ...
Tópico(s): Geological formations and processes
2006 - Oxford University Press | Geophysical Journal International
M. Janin, Christophe Hémond, Marcia Maïa, Philippe Nonnotte, Emmanuel Ponzevera, K. Johnson,
The Amsterdam–St Paul (ASP) oceanic plateau results from the interaction between the ASP hot spot and the Southeast Indian ridge. A volcanic chain, named the Chain of the Dead Poets (CDP), lies to its northward tip and is related to the hot spot intraplate activity. The ASP plateau and CDP study reveals that ASP plume composition is inherited from oceanic crust and pelagic sediments recycled in the mantle through a 1.5 Ga subduction process. The ASP plateau lavas have a composition (major and trace ...
Tópico(s): High-pressure geophysics and materials
2012 - Wiley | Geochemistry Geophysics Geosystems
Benjamin Speich, Sara Schroter, Matthias Briel, David Moher, Iratxe Puebla, Alejandra Clark, Michael Maia Schlüssel, Philippe Ravaud, Isabelle Boutron, Sally Hopewell,
Transparent and accurate reporting is essential for readers to adequately interpret the results of a study. Journals can play a vital role in improving the reporting of published randomised controlled trials (RCTs). We describe an RCT to evaluate our hypothesis that asking peer reviewers to check whether the most important and poorly reported CONsolidated Standards of Reporting Trials (CONSORT) items are adequately reported will result in higher adherence to CONSORT guidelines in published RCTs.
Tópico(s): Health and Medical Research Impacts
2020 - BMJ | BMJ Open
Islam M. Khattab, Vaidurya Pratap Sahi, Raymonde Baltenweck, Alessandra Maia‐Grondard, Philippe Hugueney, Eva Bieler, Markus Dürrenberger, Michael Riemann, Peter Nick,
Summary Grapevine trunk diseases have devastating consequences on vineyards worldwide. European wild grapevines ( Vitis vinifera subs. sylvestris ) from the last viable population in Germany along the Rhine river showed variable degrees of resistance against Neofusicoccum parvum (strain Bt‐67), a fungus associated with Botryosphaeriaceae‐related dieback. Representative genotypes from different subclades of this population were mapped with respect to their ability to induce wood necrosis, as well as their ...
Tópico(s): Forest Insect Ecology and Management
2020 - Wiley | New Phytologist
Benjamin Speich, Erika Mann, Christof Schönenberger, Katie Mellor, Alexandra Griessbach, Paula Dhiman, Pooja Gandhi, Szimonetta Lohner, Arnav Agarwal, Ayodele Odutayo, Iratxe Puebla, Alejandra Clark, An‐Wen Chan, Michael Maia Schlüssel, Philippe Ravaud, David Moher, Matthias Briel, Isabelle Boutron, Sara Schroter, Sally Hopewell,
Importance Numerous studies have shown that adherence to reporting guidelines is suboptimal. Objective To evaluate whether asking peer reviewers to check if specific reporting guideline items were adequately reported would improve adherence to reporting guidelines in published articles. Design, Setting, and Participants Two parallel-group, superiority randomized trials were performed using manuscripts submitted to 7 biomedical journals (5 from the BMJ Publishing Group and 2 from the Public Library ...
Tópico(s): Ethics in Clinical Research
2023 - American Medical Association | JAMA Network Open
Catherine Tréguier, Margot Chapuis, B. Branger, Bertrand Bruneau, A. Grellier, Kamal Chouklati, Maïa Proisy, P. Darnault, Philippe Violas, Patrick Pladys, Y. Gandon,
Tópico(s): Hip and Femur Fractures
2012 - Springer Science+Business Media | European Radiology
Maïa Proisy, A. Marchand, Philippe Loget, Renaud Bouvet, Michel Roussey, Fabienne Pelé, C. Rozel, Catherine Tréguier, P. Darnault, Bertrand Bruneau,
Tópico(s): Neuroscience of respiration and sleep
2012 - Springer Science+Business Media | European Radiology
Marina Maglakelidze, Iurie Bulat, Dinara Ryspayeva, Boris Krastev, Maia Gogiladze, Adrian Crijanovschi, Philippe Aftimos, Patrick Neven, Mark D. Pegram, Catharina Wilhelmina Menke, Elizabeth Claire Dees, Carolien P. Schröder, Agnes Jager, Linnea Chap, Erika Hamilton, Massimo Cristofanilli, Susanna V. Ulahannan, Jorianne Boers, Ramsha Iqbal, Sarika Jain,
1063 Background: Rintodestrant, a potent, oral selective estrogen receptor degrader, competitively binds and degrades the estrogen receptor (ER), thus blocking ER signaling in tumors resistant to other endocrine therapies (ET). Results from parts 1 and 2 dose-escalation/expansion indicate that once-daily (QD) rintodestrant has a favorable safety profile and antitumor activity in patients (pts) with heavily pretreated ER+/HER2– advanced breast cancer (ABC), including those with ESR1 variants (Aftimos et ...
Tópico(s): HER2/EGFR in Cancer Research
2021 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Maïa Proisy, Philippe Loget, Renaud Bouvet, Michel Roussey, Fabienne Pelé, C. Rozel, Catherine Tréguier, P. Darnault, Bertrand Bruneau,
To provide an overview of non-specific modifications on whole-body post-mortem computed tomography (PMCT) images of infants and children. 69 infants and children underwent a whole-body PMCT scan at our institution following sudden unexpected death. Two paediatric radiologists reviewed the PMCT images, specifically focusing on non-specific postmortem modifications unrelated to the presumed cause of death. Iatrogenic post-mortem modifications included focal infiltration of the legs (n=15) and hemopericardium ( ...
Tópico(s): Injury Epidemiology and Prevention
2015 - Elsevier BV | Journal of Forensic Radiology and Imaging
Laureline Berteloot, Maïa Proisy, Jean-Philippe Jaı̈s, Marilyne Lévy, Nathalie Boddaert, Damien Bonnet, Francesca Raimondi,
Tópico(s): Vascular Anomalies and Treatments
2019 - Springer Science+Business Media | Pediatric Radiology
Nuno Maia, Sven Potelle, Hamide Yildirim, Sandrine Duvet, Shyam K. Akula, Céline Schulz, Elsa Wiame, Alexander Gheldof, Katherine O’kane, Abbe Lai, Karen Sermon, Maïa Proisy, Philippe Loget, Tania Attié‐Bitach, Chloé Quēlin, Ana María Fortuna, Ana Rita Soares, Arjan P.M. de Brouwer, Emile Van Schaftingen, Marie‐Cécile Nassogne, Christopher A. Walsh, Katrien Stouffs, Paula Jorge, Anna Jansen, François Foulquier,
Free oligosaccharides (fOSs) are soluble oligosaccharide species generated during N-glycosylation of proteins. Although little is known about fOS metabolism, the recent identification of NGLY1 deficiency, a congenital disorder of deglycosylation (CDDG) caused by loss of function of an enzyme involved in fOS metabolism, has elicited increased interest in fOS processing. The catabolism of fOSs has been linked to the activity of a specific cytosolic mannosidase, MAN2C1, which cleaves α1,2-, α1,3-, and ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2022 - Elsevier BV | The American Journal of Human Genetics
Zahid Mir, A.C. Bastos, Celestino Gomes, Urs Mueller, C. Alonso, Kristina Villar, Miguel P. Rabade, Frederico Maia, Cláudia Rocha, Philippe Mainçon, Daniel Höche, M.G.S. Ferreira, Mikhail L. Zheludkevich,
Concrete possesses an intrinsic chloride binding capacity. Chloride ions from the environment bind with the hydrated cementitious phases in the form of bound chlorides. The contribution of chemically bound chlorides toward increasing the service life of concrete structures is vital as they help in slowing down the chloride diffusion in the concrete thereby delaying reinforcement depassivation. The authors attempt to increase the chloride binding capacity of concrete by adding a small amount of Mg– ...
Tópico(s): Concrete Corrosion and Durability
2020 - Wiley | Advanced Engineering Materials
Produção Nacional
Revisado por pares
Carlson de Matos Maia Leite, Johildo Salomão Figueirêdo Barbosa, Philippe Goncalvès, Christian Nicollet, Pierre Sabaté,
The Salvador–Curaçá Belt, located in São Francisco Craton, Brazil, was subjected to granulite facies metamorphism during the Paleoproterozoic orogeny (c. 2.0 Ga). Well preserved in enclaves of silica-undersaturated sapphirine-bearing granulite occur in a charnockite outcrop located along a kilometric-scale shear zone. The sapphirine-bearing granulite preserves domains with distinct mineral assemblages that record interactions between melt and peritectic phases (orthopyroxene1 + spinel1 + biotite1). Sapphirine ...
Tópico(s): earthquake and tectonic studies
2008 - Elsevier BV | Gondwana Research
Philippe Moreau, Thierry Façon, Saad Z. Usmani, Nizar J. Bahlis, Noopur Raje, Torben Plesner, Robert Z. Orlowski, Supratik Basu, Hareth Nahi, Cyrille Hulin, Hang Quach, Hartmut Goldschmidt, Michael O’Dwyer, Aurore Perrot, Christopher P. Venner, Katja Weisel, Mourad Tiab, Margaret Macro, Laurent Frenzel, Xavier Leleu, Huiling Pei, Maria Krevvata, Robin Carson, Fredrik Borgsten, Shaji Kumar,
Introduction: The MAIA study (NCT02252172) evaluated D-Rd versus Rd alone in transplant-ineligible pts with NDMM. At a median follow-up of 56.2 months, D-Rd significantly improved progression-free survival (PFS) and overall survival versus Rd (Facon T, Lancet Oncol 2021). Here, we present an analysis of clinically important subgroups in MAIA, including pts aged ≥75 years, pts with International Staging System (ISS) stage III disease, pts with renal insufficiency (defined as baseline creatinine clearance [ ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2022 - Elsevier BV | Blood
Victor Chastand, Astrid Tezenas, Yannick Cadoret, Philippe Quaegebeur, Wilson Maia, Éric Charkaluk,
Additive Manufacturing offers real opportunities in Thales, since it enables a flexible and cost-effective production of metallic components directly from a 3D digital data model. The manufacture of the parts, layer by layer, allows building more complex geometries by adding new functionalities or reducing the weight. The products of Thales can be more competitive and attractive. Studying and analysing the mechanical properties of such samples is essential. In order to be able to choose the eligible ...
Tópico(s): Titanium Alloys Microstructure and Properties
2016 - Elsevier BV | Procedia Structural Integrity
Victor Chastand, Philippe Quaegebeur, Wilson Maia, Éric Charkaluk,
Electron Beam Melting (EBM) and Selective Laser Melting (SLM) are two of the most developed powder bed fusion based additive manufacturing processes. In this paper, fatigue properties of Ti-6Al-4V specimens built by EBM and SLM are compared. Several parameters are assessed: processes, manufacturing direction, surface roughness, HIP treatment. Fatigue properties are analyzed in relation with the crack initiation mechanisms identified on each specimen's post-mortem micrographs. Machined specimens show ...
Tópico(s): Welding Techniques and Residual Stresses
2018 - Elsevier BV | Materials Characterization
Arielle Horenstein, Amanda S. Morrison, Philippe R. Goldin, Maia ten Brink, James J. Gross, Richard G. Heimberg,
Background and Objectives: Poor sleep is prevalent among individuals with social anxiety disorder (SAD) and may affect treatment outcome. We examined whether: (1) individuals with SAD differed from healthy controls (HCs) in sleep quality, (2) baseline sleep quality moderated the effects of treatment (Cognitive–behavioral group therapy [CBGT] vs. mindfulness-based stress reduction [MBSR] vs. waitlist [WL]) on social anxiety, (3) sleep quality changed over treatment, and (4) changes in sleep quality predicted ...
Tópico(s): Sleep and Wakefulness Research
2019 - Taylor & Francis | Anxiety Stress & Coping
Diogo Cruz, Cédric Delattre, Aldo Barreiro, Hugo Pereira, Guillaume Pierre, João Morais, Emmanuel Petit, Joana Silva, Joana Azevedo, Redouan Elboutachfaiti, Inês B. Maia, Pascal Dubessay, Philippe Michaud, Vı́tor Vasconcelos,
Cyanobacterial exopolysaccharides (EPS) are potential candidates for the production of sustainable biopolymers. Although the bioactive and physicochemical properties of cyanobacterial-based EPS are attractive, their commercial exploitation is limited by the high production costs. Bioprospecting and characterizing novel EPS-producing strains for industrially relevant conditions is key to facilitate their implementation in various biotechnological applications and fields. In the present work, we selected ...
Tópico(s): Aquatic Ecosystems and Phytoplankton Dynamics
2023 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Felipe Thomaz Aquino, Jefferson Luís Ferrari, Lauro June Queiroz Maia, Sidney J. L. Ribeiro, Alban Ferrier, Philippe Goldner, Rogéria Rocha Gonçalves,
This work reports on the Yb3+ ion addition effect on the near infrared emission and infrared-to-visible up conversion from planar waveguides based on Er3+–Yb3+ co-doped Nb2O5 nanocrystals embedded in SiO2-based nanocomposite prepared by a sol–gel process with controlled crystallization in situ. Planar waveguides and xerogels containing Si/Nb molar ratio of 90:10 up to 50:50 were prepared. Spherical-like orthorhombic or monoclinic Nb2O5 nanocrystals were grown in the amorphous SiO2-based host depending ...
Tópico(s): Glass properties and applications
2015 - Elsevier BV | Journal of Luminescence
A.C. Liew, Ricardo Maia Avelino, Vahid Moosavi, Tom Van Mele, Philippe Block,
Tópico(s): Interconnection Networks and Systems
2019 - Springer Science+Business Media | Structural and Multidisciplinary Optimization
Ricardo Maia Avelino, Antonino Iannuzzo, Tom Van Mele, Philippe Block,
This paper presents a methodology to assess the stability of vaulted masonry structures using Thrust Network Analysis (TNA).It offers a new numerical strategy to compute the Geometric Safety Factor (GSF) of a given structure by directly evaluating its minimum thickness.Moreover, it provides an approach for tracing the vault's stability domain based on its extreme thrust values, which indicates the robustness of the structure.Together, these outcomes represent a proper measure of the safety level of ...
Tópico(s): Structural Response to Dynamic Loads
2021 - Elsevier BV | Computers & Structures
Benoit R. Gauthier, Valérie Schwitzgebel, Maïa Zaiko, Aline Mamin, Beate Ritz-Laser, Jacques Philippé,
Abstract Glucagon gene expression in the endocrine pancreas is controlled by three islet-specific elements (G3, G2, and G4) and theα -cell-specific element G1. Two proteins interacting with G1 have previously been identified as Pax6 and Cdx2/3. We identify here the third yet uncharacterized complex on G1 as hepatocyte nuclear factor 3 (HNF-3)β, a member of the HNF-3/forkhead transcription family, which plays an important role in the development of endoderm-related organs. HNF-3 has been previously ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2002 - Oxford University Press | Molecular Endocrinology
Shaji Kumar, Philippe Moreau, Nizar J. Bahlis, Thierry Façon, Torben Plesner, Robert Z. Orlowski, Supratik Basu, Hareth Nahi, Cyrille Hulin, Hang Quach, Hartmut Goldschmidt, Michael O’Dwyer, Aurore Perrot, Christopher P. Venner, Katja Weisel, Noopur Raje, Mourad Tiab, Margaret Macro, Laurent Frenzel, Xavier Leleu, Huiling Pei, Maria Krevvata, Robin Carson, Fredrik Borgsten, Saad Z. Usmani,
Tópico(s): HIV/AIDS drug development and treatment
2022 - Elsevier BV | Blood
Philippe Gelin, Maia Milusheva,
Abstract Communities of Practice are frequently seen as key enablers of efficient corporate operations in knowledge‐intensive industries. They can improve internal communications and knowledge sharing both within an organization and between the organization and its external partners. Despite the positive effects a Community of Practice may have at any one point in time, however, its successful management over the long term requires adaptations to take into account the different stages in the life ...
Tópico(s): Open Source Software Innovations
2011 - Wiley | Global Business and Organizational Excellence
S. Antier, P. Ferrando, O. Limousin, E. Caroli, R. M. Curado da Silva, C. Blondel, R. Chipaux, V. Honkimäki, B. Horeau, Philippe Laurent, J.M. Maia, A. Meuris, S. Del Sordo, J. B. Stephen,
Since the initial exploration of the X- and soft γ-ray sky in the 60’s, high-energy celestial sources have been mainly characterized through imaging, spectroscopy and timing analysis. Despite tremendous progress in the field, the radiation mechanisms at work in sources such as neutrons stars, black holes, and Active Galactic Nuclei are still unclear. The polarization state of the radiation is an observational parameter which brings key additional information about the physical processes in these ...
Tópico(s): Astrophysical Phenomena and Observations
2015 - Springer Science+Business Media | Experimental Astronomy
Nicolas Arlicot, Johnny Vercouillie, Cécile Malherbe, Rudy Bidault, Valérie Gissot, Serge Maïa, Laurent Barantin, Jean‐Philippe Cottier, Jean‐Bernard Deloye, Denis Guilloteau, Maria-João Ribeiro,
The aim of this study was to evaluate in healthy human brain the distribution, uptake, and kinetics of [18F]LBT-999, a PET ligand targeting the dopamine transporter, to assess its ability to explore dopaminergic innervation, using a shorter protocol, more convenient for patients than currently with [123I]ioflupane.After intravenous injection of [18F]LBT-999, 8 healthy subjects (53-80y) underwent a dynamic PET-scan. Venous samples were concomitantly obtained for metabolites analysis. Time activity curves ( ...
Tópico(s): Neuroscience and Neuropharmacology Research
2022 - | The Quarterly Journal of Nuclear Medicine and Molecular Imaging
Ana Veríssimo, L.C. Alves, Paulo Filipe, João Maia Silva, Raquel Silva, M.D. Ynsa, Étienne Gontier, Philippe Moretto, Jan Pallon, Teresa Pinheiro,
Abstract Nuclear microscopy is a technique based on a focused beam of accelerated particles that has the ability of imaging the morphology of the tissue in vivo and of producing the correspondent elemental maps, whether in major, minor, or trace concentrations. These characteristics constitute a strong advantage in studying the morphology of human skin, its elemental distributions and the permeation mechanisms of chemical compounds. In this study, nuclear microscopy techniques such as scanning transmission ...
Tópico(s): Molecular Biology Techniques and Applications
2007 - Wiley | Microscopy Research and Technique
Produção Nacional
Revisado por pares
Lauro June Queiroz Maia, Valmor Roberto Mastelaro, J. Schneider, Philippe Parent, C. Laffon,
The structure of barium–titanium–metaborate xBaO–xB2O3–yTiO2 (y=0%, 4%, 8%, 16% and x=50–y/2) amorphous and crystallized powders, obtained using a polymeric precursor method, was investigated by Ti and B K-edge X-ray absorption spectroscopy (XAS) and 11B-NMR high-resolution techniques. XANES study of amorphous samples shows that Ti4+ ions exist as [4]Ti species associated to [6]Ti and [5]Ti species in a practically equivalent amount. After crystallization, titanium environment is predominately composed ...
Tópico(s): Advanced Condensed Matter Physics
2005 - Elsevier BV | Journal of Solid State Chemistry
Produção Nacional
Revisado por pares
Romualdo S. Silva, Nilson S. Ferreira, Jean-Philippe Fontes, M.E.H. Maia da Costa, Petrucio Barrozo,
We investigate the Sr2+-doping influence on the structural, chemical, and magnetic properties of LaCrO3 prepared by a modified combustion method. X-ray diffraction (XRD) results indicate that samples crystallized in an orthorhombic structure, which were stable in heat treatments lower 1073 K. X-ray photoelectron spectroscopy (XPS) results showed a tendency to favor the oxidize of Cr3+ forming more Cr4+ and Cr6+ ions for the La0.9Sr0.1CrO3. The magnetic measurements reveal that the Sr2+-doping does ...
Tópico(s): Multiferroics and related materials
2021 - Elsevier BV | Chemical Physics Letters