Produção Nacional
Revisado por pares
Fidel Ernesto Morales Vicente, Melaine González-García, Erbio Díaz Pico, Elena Moreno Castillo, Hilda Garay, Pablo Rosi, Asiel Mena Jimenez, José A. C. Delgado, Daniel G. Rivera, Glay Chinea, Rosemeire Cristina Linhari Rodrigues Pietro, Steffen Stenger, Barbara Spellerberg, Dennis Kubiczek, Nicholas Bodenberger, Steffen Dietz, Frank Rosenau, Márcio W. Paixão, Ludger Ständker, Anselmo J. Otero‐González,
Following the information obtained by a rational design study, a cyclic and helical-stabilized analogue of the peptide Cm-p5 was synthetized. The cyclic monomer showed an increased activity in vitro against Candida albicans and Candida parapsilosis, compared to Cm-p5. Initially, 14 mutants of Cm-p5 were synthesized following a rational design to improve the antifungal activity and pharmacological properties. Antimicrobial testing showed that the activity was lost in each of these 14 analogues, suggesting, ...
Tópico(s): Cancer therapeutics and mechanisms
2019 - American Chemical Society | ACS Omega
Sònia Jaraba, Estevo Santamarina, Júlia Miró, Manuel Toledo, A. Molins, J. Burcet, Juan Luís Becerra, Miquel Raspall‐Chaure, Guillermo A. do Pico, Elena Miravet, A Cano, P Fossas, Secundino Fernández, Mercé Falip,
To explore the long-term effectiveness of rufinamide in managing Lennox-Gastaut Syndrome (LGS), other epileptic encephalopathies, and intractable focal epilepsies in adults and children in routine clinical practice.A multicentre, retrospective chart review of patients prescribed adjunctive rufinamide at seven Spanish epilepsy centres, with assessments at six and 12 months.We evaluated data from 58 patients (40 male, age range 7-57 years), 25 of whom were diagnosed with LGS, 12 with other epileptic ...
Tópico(s): Drug Transport and Resistance Mechanisms
2016 - Wiley | Acta Neurologica Scandinavica
Philippe Touraine, Gwyn D'Souza, IONE A. KOURIDES, Roger Abs, Paul L. Barclay, Rujia Xie, Antonio Picó, Elena Torres‐Vela, Bertil Ekman,
Changes observed during adult GH deficiency (GHD) are most often reversed with the administration of recombinant human GH (rhGH). To avoid daily injections, a long-acting GH molecule has been obtained by covalent binding of polyethylene glycol (PEG) with rhGH (PEG-GH), allowing weekly s.c. injections. This study was designed to assess its efficacy and safety, in adult GHD subjects.This was a randomized, double-blind, placebo-controlled, multiple-dose, parallel group study. Subjects were recruited from ...
Tópico(s): Lipid metabolism and disorders
2009 - Oxford University Press | European Journal of Endocrinology
Nora B. Calcaterra, Guillermo Picó, Elena G. Orellano, Jorgelina Ottado, Néstor Carrillo, Eduardo A. Ceccarelli,
The contribution made by tyrosine 308 to the stability of pea ferredoxin-NADP+ reductase was investigated using site-directed mutagenesis. The phenol side chain of the invariant carboxyl terminal tyrosine is stacked coplanar to the isoalloxazine moiety of the FAD cofactor. Fluorescence measurements indicate that this interaction plays a significant role in FAD fluorescent quenching by the reductase apoprotein. Replacement of the tyrosine by tryptophan or phenylalanine caused only a minor increase ...
Tópico(s): Signaling Pathways in Disease
1995 - American Chemical Society | Biochemistry
Miguel Català Bauset, Alberto Gilsanz Peral, Frederic Tortosa Henzi, Ana Zugasti Murillo, Basilio Moreno Esteban, Irene Halperin Ravinovich, Tomás Lucas Morante, Gabriel Obiols Alfonso, Concecpción Páramo Fernández, Antonio Picó, Carlos del Pozo Picó, Elena Torres Vela, César Varela da Costa, Susan Webb Youdale, Carlos Villabona Artero,
La homeostasis del agua corporal se halla regulada por la ingesta de agua que depende principalmente de la sed y de la excreción urinaria modulada, fundamentalmente, por la vasopresina (AVP). En ausencia de AVP el túbulo colector es impermeable a la difusión de agua, dando lugar a una diuresis acuosa o diluida con osmolalidades urinarias menores a 100 mOsm/kg. Por el contrario, en presencia de AVP, la permeabilidad se incrementa considerablemente, el agua es reabsorbida libre de solutos y la orina ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2007 - Elsevier BV | Endocrinología y Nutrición
Geòrgia Sarquella-Brugada, Óscar García‐Algar, M.D.C. Beato Zambrano, Anna Fernández-Falgueres, Sebastian Sailer, Sergi César, Giorgia Sebastiani, Julio Martí‐Almor, Esther Aurensanz, José Cruzalegui, Erika Fernanda Merchan, Mónica Coll, Alexandra Pérez‐Serra, Bernat del Olmo, Victoria Fiol, Anna Iglesias, Carles Ferrer‐Costa, Marta Puigmulé, Laura López, Ferran Picó, Elena Arbelo, Paloma Jordà, Josép Brugada, Ramón Brugada, Óscar Campuzano,
Long QT syndrome is the main arrhythmogenic disease responsible for sudden death in infants, especially in the first days of life. Performing an electrocardiogram in newborns could enable early diagnosis and adoption of therapeutic measures focused on preventing lethal arrhythmogenic events. However, the inclusion of an electrocardiogram in neonatal screening protocols still remains a matter of discussion. To comprehensively analyse the potential clinical value of performing an electrocardiogram ...
Tópico(s): ECG Monitoring and Analysis
2021 - Frontiers Media | Frontiers in Pediatrics
Alberto Parras, Alba Vílchez-Acosta, Gabriela Desdín-Micó, Sara Picó, Calida Mrabti, Elena Montenegro-Borbolla, Céline Yacoub Maroun, Amin Haghani, Robert T. Brooke, María del Carmen Lapo Maza, Cheyenne Rechsteiner, Fabrice Battiston, Clémence Branchina, Kevin Pérez, Steve Horvath, Claire Bertelli, Christine Sempoux, Alejandro Ocampo,
The induction of cellular reprogramming via expression of the transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM) can drive dedifferentiation of somatic cells and ameliorate age-associated phenotypes in multiple tissues and organs. However, the benefits of long-term in vivo reprogramming are limited by detrimental side-effects. Here, using complementary genetic approaches, we demonstrated that continuous induction of the reprogramming factors in vivo leads to hepatic and intestinal dysfunction ...
Tópico(s): Pancreatic function and diabetes
2023 - Nature Portfolio | Nature Aging
Fernando Pico, Charlotte Rosso, Elena Meseguer, Marie‐Laure Chadenat, Amina Cattenoy, Philippe Aegerter, S. Deltour, Jennifer Yeung, Hassan Hosseini, Yves Lambert, Didier Smadja, Yves Samson, Pierre Amarenco,
Rationale Remote ischemic per-conditioning—causing transient limb ischemia to induce ischemic tolerance in other organs—reduces final infarct size in animal stroke models. Aim To evaluate whether remote ischemic per-conditioning during acute ischemic stroke (<6 h) reduces brain infarct size at 24 h. Methods and design This study is being performed in five French hospitals using a prospective randomized open blinded end-point design. Adults with magnetic resonance imaging confirmed ischemic stroke ...
Tópico(s): Anesthesia and Neurotoxicity Research
2016 - SAGE Publishing | International Journal of Stroke
Gemma Sesmilo, Eugenia Resmini, Ignacio Bernabéu, Javier Aller, Alfonso Soto, Mireia Mora, Antonio Picó, Carmen Fajardo, Elena Torres, Cristina Álvarez‐Escolá, Rogelio García, Concepción Blanco, Rosa Cámara, Sonia Gaztambide, Isabel Salinas, Juan C. del Pozo, Ignasi Castells, Carles Villabona, Betina Biagetti, Susan M. Webb,
Summary Background Pegvisomant is an effective treatment for acromegaly. Objective To investigate escape (loss of biochemical control in patients previously controlled) and lipodystrophy in acromegalic patients treated with pegvisomant and to evaluate possible associations with clinical features. Patients and methods Multicentre retrospective study involving 19 Spanish centres. Results Ninety‐seven patients were included (59% women, mean age at diagnosis 42 ± 13 years, 80% macroadenomas); mean follow‐ ...
Tópico(s): TGF-β signaling in diseases
2014 - Wiley | Clinical Endocrinology
María Luisa Granada, Àngels Ulied, Felipe F. Casanueva, Antonio Picó, Tomás Lúcas, Elena Torres, Anna Sanmartı́,
Summary Background IGF‐I is a useful tool in GH disorders diagnosis, however, the use of commercially available kits needs to be validated. Objective To validate the use of serum IGF‐I concentrations measured by four immunoassays in the diagnosis of adult GH deficiency and acromegaly. Design Cross‐sectional study. Patients Fifty GH‐deficient (GHD) patients, 41 acromegaly patients and 405 controls. Measurements Serum IGF‐I concentrations were measured by four commercial immunoassays: (1) RIA‐NICHOLS; ( ...
Tópico(s): Neuroendocrine Tumor Research Advances
2007 - Wiley | Clinical Endocrinology
Gabriel Bosque, Abel Folch‐Fortuny, Jesús Picó, Alberto Ferrer, Santiago F. Elena,
One of the central interests of Virology is the identification of host factors that contribute to virus infection. Despite tremendous efforts, the list of factors identified remains limited. With omics techniques, the focus has changed from identifying and thoroughly characterizing individual host factors to the simultaneous analysis of thousands of interactions, framing them on the context of protein-protein interaction networks and of transcriptional regulatory networks. This new perspective is ...
Tópico(s): Plant-Microbe Interactions and Immunity
2014 - Springer Science+Business Media | BMC Systems Biology
Miguel Català Bauset, Alberto Gilsanz Peral, Juan Girbés Borràs, Ana Zugasti Murillo, Basilio Moreno Esteban, Irene Halperín, Gabriel Obiols Alfonso, Antonio Picó, Carlos del Pozo Picó, Alfonso Soto Moreno, Elena Torres Vela, Frederic Tortosa Henzi, Tomás Lucas Morante, Concha Páramo Fernández, César Varela da Ousa, Carles Villabona Artero,
Hypophysitis are a group of inflammatory lesions affecting the pituitary gland and pituitary stalk. These lesions should be included in the differential diagnosis of sellar masses. There are three types of primary hypophysitis: lymphocytic, granulomatous and xanthomatous. Lymphocytic hypophysitis is the most frequent form of chronic pituitary inflammation and is believed to have an autoimmune origin. This form characteristically affects women during the peripartum, with diverse types of pituitary ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2008 - Elsevier BV | Endocrinología y Nutrición
Kanjana Perera, Danielle de Sá Boasquevisque, Rao Ps, Amanda Taylor, Anna Cheng, Graeme J. Hankey, Sarah Lee, J. Martí Fàbregas, Sebastián F. Ameriso, Thalia S. Field, Antonio Araúz, Shelagh B. Coutts, Marcel Arnold, Robert Mikulík, Danilo Toni, Jennifer Mandzia, Roland Veltkamp, Elena Meseguer, Karl Georg Hæusler, Robert G. Hart, Sebastián F. Ameriso, Daiana Dossi, Federico Rodríguez Lucci, Julieta Rosales, Maia Gómez Schneider, Maria Soledad Rodrı́guez González, Matías Alet, Virginia Pujol Lereis, Guillermo Povedano, María Verónica Marroquín, Tissa Wijeratne, Elizabeth A. Mackey, Elyce Warburton, Fatemeh Rezania, Timothy Kleinig, Erin Kelly, Jackson D. Harvey, Sumiti Nayar, Kanjana Perera, Thalia S. Field, Shelagh B. Coutts, Dominic Tse, Eric E. Smith, Ericka Teleg, Michael D. Hill, Ravinder Signh, Jennifer Mandzia, Aleksandra Pikula, GRANT Stotts, Verónica V. Olavarría, Enrico Mazzon, Elena Meseguer, Fernando Pico, Bernd Kallmuenzer, Julia Koehn, Kosmas Macha, Sebastian S. Roeder, Christian H. Nolte, Ida Randus, Jonas Bader, Rohat Geran, Serdar Tuetuencue, Günter Seidel, Kuecken Detmar, Antonio Araúz, Anna Członkowska, Dorota Kozera, Marcin Głuszkiewicz, Michał Karliński, Waldemar Brola, Malgorzata Ziomek, Matthys Basson, Maria E. Pretorius, Juan F. Arenillas, Elisa Cortijo Garcia, Joan Martí‐Fàbregas, Meritxell Gomis, Lucía Muñoz-Narbona, Marcel Arnold, Basel Maamari, Jan Vynckier, Martina Goldlin, Simon Jung, Thomas Horvath, Thomas R. Meinel, Hugh S. Markus, J Chembala, Christine Roffe, Janaka Weerathunga, Nenette Abano, Phillip Ferdinand, Roland Veltkamp, Abid Malik, Ambreen Ali Sheikh, Lucio D’Anna, Omid Halse, Soma Banerjee, Urszula Bojaryn, Ali Ali, Aaizza Naqvi, Arshad Majid, Jessica Redgrave, Kirsty Harkness, Ralf Lindert, David Collas, Mohit Bhandari, Khalid Rashed, C Buckley, Paul Guyler, Nisha Menon, Matthew B. Burn, Nasar Ahmad, Chris Wharton, David Cohen, Raj Bathula, Dipankar Dutta, Mudhar Obaid, Gunaratnam Gunathilagan, Salim Elyas, Adrian Renouf, A. Bowring, Sarah Lee, Pramodkumar Sethi, Jindong Xu, Alberto Maud, Lee Birnbaum, Souvik Sen, Helmi L. Lutsep,
Importance Cryptogenic strokes constitute approximately 40% of ischemic strokes in young adults, and most meet criteria for the embolic stroke of undetermined source (ESUS). Two randomized clinical trials, NAVIGATE ESUS and RESPECT ESUS, showed a high rate of stroke recurrence in older adults with ESUS but the prognosis and prognostic factors among younger individuals with ESUS is uncertain. Objective To determine rates of and factors associated with recurrent ischemic stroke and death and new-onset atrial ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2022 - American Medical Association | JAMA Neurology
Tomáš Kalina, Marina Bakardjieva, Maartje Blom, Martín Pérez‐Andres, Barbara H. Barendregt, Veronika Kanderová, Carolien Bonroy, Jan Philippé, Elena Blanco, Ingrid Pico‐Knijnenburg, Jitse H. M. P. Paping, Beata Wolska‐Kuśnierz, Małgorzata Pac, Jakub Tkazcyk, Filomeen Haerynck, Himmet Haluk Akar, Renata Formánková, Tomáš Freiberger, Michael Svatoň, Anna Šedivá, Sonia de Arriba, Alberto Órfão, Jacques J. M. van Dongen, Mirjam van der Burg,
The EuroFlow PID consortium developed a set of flow cytometry tests for evaluation of patients with suspicion of primary immunodeficiency (PID). In this technical report we evaluate the performance of the SCID-RTE tube that explores the presence of recent thymic emigrants (RTE) together with T-cell activation status and maturation stages and discuss its applicability in the context of the broader EuroFlow PID flow cytometry testing algorithm for diagnostic orientation of PID of the lymphoid system. ...
Tópico(s): T-cell and B-cell Immunology
2020 - Frontiers Media | Frontiers in Immunology
Manel Puig‐Domingo, Joan Gil, Miguel Sampedro‐Núñez, Mireia Jordà, Susan M. Webb, Guillermo Serra, Laura Pons, Isabel Salinas, Alberto Blanco, Montserrat Marqués-Pamies, Elena Valassi, Antonio Picó, Araceli García‐Martínez, Cristina Carrato, Raquel Buj, Juan C. del Pozo, Gabriel Obiols, Carles Villabona, Rosa Cámara, Carmen Fajardo, Clara V. Álvarez, Ignacio Bernabéu, Mónica Marazuela,
Pharmacologic treatment of acromegaly is currently based upon assay-error strategy, the first-generation somatostatin receptor ligands (SRL) being the first-line treatment. However, about 50% of patients do not respond adequately to SRL. Our objective was to evaluate the potential usefulness of different molecular markers as predictors of response to SRL. We used somatotropinoma tissue obtained after surgery from a national cohort of 100 acromegalic patients. Seventy-one patients were treated with ...
Tópico(s): Adrenal and Paraganglionic Tumors
2020 - Bioscientifica | Endocrine Related Cancer
Daniel Valderas Castilla, Cristina Bravo Páramo, Juan Ignacio Torres‐González, Amparo Corniero Pico, Raquel Ambit Lemus, Elena López Almorox, María Jesús Simón García, A.L. Blesa Malpica,
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2004 - Elsevier BV | Enfermería Intensiva
Gemma Sesmilo, Sonia Gaztambide, Eva Venegas, Antonio Picó, Juan C. del Pozo, Concepción Blanco, Elena Torres, Cristina Álvarez‐Escolá, Carmen Fajardo, Rogelio García, Rosa Cámara, Ignacio Bernabéu, Alfonso Soto, Carles Villabona, Alicia Serraclara, Irene Halperín, Victoria Alcázar, Elísabet Palomera, Susan M. Webb,
Tópico(s): Adrenal and Paraganglionic Tumors
2012 - Springer Science+Business Media | Pituitary
David de Gonzalo‐Calvo, Iván D. Benítez, Lucía Pinilla, Amara Carratalá, Anna Moncusí‐Moix, Clara Gort‐Paniello, Marta Molinero, Jessica González, Gerard Torres, M. Bernal, Silvia Picó, Raquel Almansa, Noelia Jorge, Alicia Ortega, Elena Bustamante‐Munguira, José M. Gómez, Milagros González‐Rivera, Dariela Micheloud, Pablo Ryan, Amalia Martínez, Luís Tamayo, César Aldecoa, Ricard Ferrer, Adrián Ceccato, Laia Fernández‐Barat, Ana Motos, Jordi Riera, Rosario Menéndez, Dario García-Gasulla, Óscar Peñuelas, Antoní Torres, Jesús F. Bermejo-Martín, Ferrán Barbé,
We aimed to examine the circulating microRNA (miRNA) profile of hospitalized COVID-19 patients and evaluate its potential as a source of biomarkers for the management of the disease. This was an observational and multicenter study that included 84 patients with a positive nasopharyngeal swab Polymerase chain reaction (PCR) test for SARS-CoV-2 recruited during the first pandemic wave in Spain (March-June 2020). Patients were stratified according to disease severity: hospitalized patients admitted to ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Elsevier BV | Translational research
Fernando Pico, Bertrand Lapergue, Marc Ferrigno, Charlotte Rosso, Elena Meseguer, Marie‐Laure Chadenat, Frédéric Bourdain, Michaël Obadia, Catherine Hirel, Duc Long Duong, S. Deltour, Philippe Aegerter, Julien Labreuche, Amina Cattenoy, Didier Smadja, Hassan Hosseini, B. Guillon, Valérie Wolff, Yves Samson, Charlotte Cordonnier, Pierre Amarenco,
Importance Treatment with remote ischemic perconditioning has been reported to reduce brain infarction volume in animal models of stroke. Whether this neuroprotective effect was observed in patients with acute ischemic stroke remains unknown. Objective To determine whether treatment with remote ischemic perconditioning administered to the leg of patients with acute ischemic stroke can reduce brain infarction volume growth. Design, Setting, and Participants This proof-of-concept multicenter prospective randomized ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2020 - American Medical Association | JAMA Neurology
Juan J. Villora‐Picó, Víctor Belda-Alcázar, Mariano García-Fernández, Elena Serrano, Antonio Sepúlveda‐Escribano, M. Mercedes Pastor‐Blas,
Materials able to produce the reduction of nitrate from water without the need of a metal catalyst and with avoiding the use of gaseous hydrogen have been developed by combining the synergistic properties of titania and two conducting polymers. Polymerization of aniline and pyrrol on titanium dioxide in the presence of two different oxidants/dopants (iron trichloride or potassium persulfate) has been evaluated. The resulting hybrid materials have good thermal stability imparted by the titania counterpart, ...
Tópico(s): Nanomaterials for catalytic reactions
2019 - American Chemical Society | Langmuir
Shuqing Si, Anbreen Bi, Zhaoying Yu, Cheryl R. Z. See, Sinéad Kelly, Sonia Ambrogi, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Michael Berk, Josefina Castro‐Fornieles, Benedicto Crespo‐Facorro, Jacob J. Crouse, Covadonga M. Díaz‐Caneja, Anne‐Kathrin Fett, Adriana Fortea, Sophia Frangou, Benjamin I. Goldstein, Ian B. Hickie, Joost Janssen, Kody G. Kennedy, Lydia Krabbendam, Marinos Kyriakopoulos, Bradley J. MacIntosh, Pedro Morgado, Stener Nerland, Saül Pascual‐Diaz, Maria Picó‐Pérez, Fabrizio Piras, Bjørn Rishovd Rund, Elena de la Serna, Gianfranco Spalletta, Gisela Sugranyes, Chao Suo, Diana Tordesillas‐Gutiérrez, Daniela Vecchio, Joaquim Raduà, Philip McGuire, Sophia I. Thomopoulos, Neda Jahanshad, Paul M. Thompson, Cláudia Barth, Ingrid Agartz, Anthony James, Matthew J. Kempton,
Abstract Introduction Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies have yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole brain voxel-based morphometry (VBM) analysis in a large sample of individuals with EOP, using the newly developed ENIGMA-VBM tool. Methods 15 independent cohorts from the ENIGMA-EOP working group participated ...
Tópico(s): Schizophrenia research and treatment
2024 - Springer Nature | Molecular Psychiatry
Irene Mademont‐Soler, Mel·lina Pinsach‐Abuin, Helena Riuró, Jesús Matés, Alexandra Pérez‐Serra, Mónica Coll, José Manuel Porres, Bernat del Olmo, Anna Iglesias, Elisabet Selga, Ferran Picó, Sara Pagans, Carles Ferrer‐Costa, Geòrgia Sarquella-Brugada, Elena Arbelo, Sergi César, Josép Brugada, Óscar Campuzano, Ramón Brugada,
Brugada syndrome (BrS) is a form of cardiac arrhythmia which may lead to sudden cardiac death. The recommended genetic testing (direct sequencing of SCN5A) uncovers disease-causing SNVs and/or indels in ~20% of cases. Limited information exists about the frequency of copy number variants (CNVs) in SCN5A in BrS patients, and the role of CNVs in BrS-minor genes is a completely unexplored field.220 BrS patients with negative genetic results were studied to detect CNVs in SCN5A. 63 cases were also screened ...
Tópico(s): Viral Infections and Immunology Research
2016 - Public Library of Science | PLoS ONE
José Luís Bernal Muñoz, María Oliva Alvarez, Vicent Cuquerella, Elena Miranda, Carlos del Pozo Picó, Raquel Flores, Marta Resalt-Pereira, Pedro Moya, Ana Martínez Pérez, Antonio Arroyo,
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2018 - Springer Science+Business Media | Surgical Endoscopy
Estefanía Martinez-Barrios, Geòrgia Sarquella-Brugada, Alexandra Pérez‐Serra, Anna Fernàndez-Falgueras, Sergi César, Mireia Alcalde, Mónica Coll, Marta Puigmulé, Anna Iglesias, Carles Ferrer‐Costa, Bernat del Olmo, Ferran Picó, Laura López, Victoria Fiol, José Cruzalegui, Clara Hernández, Elena Arbelo, Núria Díez-Escuté, Patricia Cerralbo, Simone Grassi, Antonio Oliva, Rocío Toro, Josép Brugada, Ramón Brugada, Óscar Campuzano,
Abstract Sudden death cases in the young population remain without a conclusive cause of decease in almost 40% of cases. In these situations, cardiac arrhythmia of genetic origin is suspected as the most plausible cause of death. Molecular autopsy may reveal a genetic defect in up to 20% of families. Most than 80% of rare variants remain classified with an ambiguous role, impeding a useful clinical translation. Our aim was to update rare variants originally classified as of unknown significance ...
Tópico(s): Genetic Associations and Epidemiology
2023 - Springer Science+Business Media | International Journal of Legal Medicine
Produção Nacional
Revisado por pares
Raúl Humberto Montaluisa Pulloquinga, José Augusto Cadena Moreano, Luis Efraín Cayo Lema, Oscar Alejandro Guaypatín Pico, María Elena Tapia Granada,
El Calentamiento Global viene afectando a todo el mundo desde hace alrededor de 15 anos, con cambios que al principio parecian imperceptibles a la sensibilidad humana, pero que actualmente son absolutamente notorios y muy drasticos.Entre otros se encuentran los cambios climaticos presentes en la ciudad de Latacunga, al encontrarse en la serrania ecuatoriana y casi al pie del mundialmente conocido volcan Cotopaxi, susceptible a climas frios y calidos, provocado por los rayos perpendiculares del sol ...
Tópico(s): Health and Lifestyle Studies
2017 - Editorial Redipe | Revista Boletín Redipe
David Pérez-Manchón, María Lorena Rodríguez-Álvarez, Claudia Alcívar-Arteaga, Mercedes Redondo-Pico, Elena Ramos-Quirós,
Conocer el perfil de morbilidad cardiovascular, grado de control y estilos de vida en diabetes tipo 2. Estudio transversal multicéntrico aleatorizado realizado en 2015 en atención primaria con 129 diabéticos. Incluyó variables sociodemográficas, complicaciones micro- y macrovasculares, daño orgánico, comorbilidad y estilos de vida de tabaquismo, ejercicio y adherencia a dieta mediterránea. El control metabólico se valoró con la última hemoglobina glucosilada anual. El 57,4% eran hombres y el 42, ...
Tópico(s): Diabetes and associated disorders
2016 - Elsevier BV | Enfermería Clínica
Rodrigo Picos, Elena García, M. Estrada, A. Cerdeira, Benjamı́n Iñiguez,
We have studied the effect of some of the possible deviations on the values of the extracted parameters of a specific OTFT model, considering OTFTs designed using P 3 HT as semiconductor layer, PMMA as insulator, bottom gate, and top gold contacts. Specifically, we have studied the influence of misposition or misalignment of the masks, the effect of imperfections of etching, and the effect of variations on the layer deposition process. These effects have been simulated using the Silvaco Athena software, ...
Tópico(s): Advancements in Photolithography Techniques
2011 - World Scientific | International Journal of High Speed Electronics and Systems
Joan Gil, Montserrat Marqués-Pamies, Miguel Sampedro, Susan M. Webb, Guillermo Serra, Isabel Salinas, Alberto Blanco, Elena Valassi, Cristina Carrato, Antonio Picó, Araceli García‐Martínez, Luciana Martel‐Duguech, Teresa Sardón, Andreu Simó-Servat, Betina Biagetti, Carles Villabona, Rosa Cámara, Carmen Fajardo, Cristina Álvarez‐Escolá, Cristina Lamas, Clara V. Álvarez, Ignacio Bernabéu, Mónica Marazuela, Mireia Jordà, Manel Puig‐Domingo,
Abstract Predicting which acromegaly patients could benefit from somatostatin receptor ligands (SRL) is a must for personalized medicine. Although many biomarkers linked to SRL response have been identified, there is no consensus criterion on how to assign this pharmacologic treatment according to biomarker levels. Our aim is to provide better predictive tools for an accurate acromegaly patient stratification regarding the ability to respond to SRL. We took advantage of a multicenter study of 71 ...
Tópico(s): Neuroendocrine Tumor Research Advances
2022 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Evgenios Agathokleous, Damià Barceló, Michael Aschner, Ricardo Antunes Azevedo, Prosun Bhattacharya, David Costantini, G. Christopher Cutler, Alessandra De Marco, Anca Oana Docea, José G. Dórea, Stephen O. Duke, Thomas Efferth, Despo Fatta‐Kassinos, Vasileios Fotopoulos, Antonio Ginebreda, R. N. C. Guedes, A. Wallace Hayes, Ivo Iavicoli, Olga‐Ioanna Kalantzi, Takayoshi Koike, Demetrios Kouretas, Manish Kumar, José E. Manautou, Michael N. Moore, Elena Paoletti, Josep Peñuelas, Yolanda Picó, Rüssel J. Reiter, Ramin Rezaee, Jörg Rinklebe, Teresa Rocha‐Santos, Pierre Sicard, Christian Sonne, Christopher M. Teaf, Aristidis Tsatsakis, Constantine Vardavas, Wenjie Wang, Eddy Y. Zeng, Edward J. Calabrese,
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVViewpointNEXTRethinking Subthreshold Effects in Regulatory Chemical Risk AssessmentsEvgenios Agathokleous*Evgenios AgathokleousCollaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters (CIC-FEMD), Nanjing University of Information Science & Technology, Nanjing 210044, Jiangsu ChinaResearch Center for Global Changes and Ecosystem Carbon Sequestration & Mitigation, School of Applied Meteorology, Nanjing University of Information Science & ...
Tópico(s): Pesticide Exposure and Toxicity
2022 - American Chemical Society | Environmental Science & Technology
Pierre Amarenco, Kim Js, Julien Labreuche, Hubert Charles, Jérémy Abtan, Yannick Béjot, L. Cabrejo, Cha Jk, Grégory Ducrocq, Maurice Giroud, Céline Guidoux, Cristina Hobeanu, Kim Yj, Bertrand Lapergue, Philippa C. Lavallée, Lee Bc, Lee Kb, Didier Leys, Mahagne Mh, Elena Meseguer, Norbert Nighoghossian, Fernando Pico, Yves Samson, Igor Sibon, Philippe Gabríel Steg, Sung Sm, Pierre‐Jean Touboul, Emmanuel Touzé, Olivier Varenne, Éric Vicaut, Nessima Yelles, Éric Bruckert,
The use of intensive lipid-lowering therapy by means of statin medications is recommended after transient ischemic attack (TIA) and ischemic stroke of atherosclerotic origin. The target level for low-density lipoprotein (LDL) cholesterol to reduce cardiovascular events after stroke has not been well studied.
Tópico(s): Acute Ischemic Stroke Management
2019 - Massachusetts Medical Society | New England Journal of Medicine