R. Coutant, Paul Landais, Myriam Rosilio, Christin Johnsen, N. Lahlou, Pierre Chatelain, Jean‐Claude Carel, Johnny Ludvigsson, Christian Boîtard, Pierre Bougnères,
The quinoline-3-carboxamide, linomide, protects non-obese diabetic mice from diabetes. The effects of linomide on insulin needs and beta cell function were studied in recent juvenile Type I diabetes in a double-blind trial. Patients with recent onset diabetes were randomly assigned to treatment with a fixed dose of 2.5 mg linomide (42 patients) or placebo (21 patients) for 1 year, in addition to insulin and diet. Glycated haemoglobin was 10–15 % lower at 9 months (p = 0.003) and 12 months (p < 0.05) in the ...
Tópico(s): Diabetes Management and Research
1998 - Springer Science+Business Media | Diabetologia
Philippe Mathurin, Florent Gonzalez, Olivier Kerdraon, Emmanuelle Leteurtre, Laurent Arnalsteen, Antoine Hollebecque, Alexandre Louvet, Sébastien Dharancy, Perrine Cocq, T. Jany, J. Boitard, Pierre Deltenre, Monique Romon, François Pattou,
Background & Aims: In severely obese patients, factors implicated in the evolution of severe steatosis after bariatric surgery remain unresolved. Our aim was to determine whether insulin resistance (IR) influences the histologic effects induced by bariatric surgery. Methods: We prospectively included 185 severely obese patients (body mass index ≥35 kg/m2) referred for bariatric surgery. The evolution of IR (IR index = 1/quantitative insulin sensitivity check index) and liver injury with consecutive biopsy ...
Tópico(s): Diet and metabolism studies
2006 - Elsevier BV | Gastroenterology
Gianpaolo De Filippo, Jean‐Claude Carel, Christian Boîtard, Pierre-François Bougnères,
In juvenile IDDM patients, immunosuppression with cyclosporin A allows partial beta-cell function recovery and transient remissions of insulin dependency. The effects of this therapeutic approach, however, have not been evaluated in the long-term, since no reported trial exceeded 1 year. Here we analyze 130 diabetic children followed at our institution during the first years of their disease. Cyclosporin was given to 83 of them at an initial dose of 7.2 ± 0.1 mg·kg−1·day−1, which was decreased stepwise ...
Tópico(s): Genetics and Neurodevelopmental Disorders
1996 - American Diabetes Association | Diabetes
G. De Filippo, J. C. Carel, C. Boitard, Pierre-François Bougnères,
Tópico(s): Adenosine and Purinergic Signaling
1996 - American Diabetes Association | Diabetes
Jean‐Claude Carel, Christian Boîtard, Pierre Bougnères,
Measurement of beta-cell function is an important marker of progression to diabetes in individuals at risk for the disease. Although the peak incidence for the disease occurs before 17 years of age, normal values for insulin secretion were not available in this age group. We performed a simplified intravenous glucose tolerance test in 167 normal children, and in 98 islet cell antibody (ICA)-negative and 12 ICA-positive siblings of diabetic patients. Their age range was 1-16 yr. The first phase of ...
Tópico(s): Diabetes Management and Research
1993 - American Society for Clinical Investigation | Journal of Clinical Investigation
Albert Bendelac, Christian Boîtard, Pierre Bédossa, Hervé Bazin, J F Bach, Claude Carnaud,
The autoimmune nonobese diabetic mouse, a model of human juvenile type I diabetes mellitus, exhibits features of both B and T cell autoreactivity against insulin-producing cells. Using the neonatal cell transfer model of the disease, which we have described previously, we have shown that B cell suppression of newborn recipients by anti-mu treatment did not affect the transfer of diabetes by means of T cells. B cell-depleted, purified T cells from diabetic adults were injected into newborns treated ...
Tópico(s): Diabetes Management and Research
1988 - American Association of Immunologists | The Journal of Immunology
Luís Castaño, Christian Boîtard, Pierre-François Bougnères,
We report that cyclosporin A (CsA) suppresses the insulin autoantibodies that are present before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic children. CsA also reversibly blocks the production of antibodies after exogenous insulin injection, whereas high titers of heterologous insulin antibody are observed in all type I patients not receiving CsA.
Tópico(s): Diabetes Treatment and Management
1988 - American Diabetes Association | Diabetes
Valérie Bellamy, Valérie Vanneaux, Alain Bel, Hany Nemetalla, Solène Emmanuelle Boitard, Yohan Farouz, Pierre Joanne, Marie‐Cécile Perier, Estelle Robidel, Chantal Mandet, Albert Hagège, Patrick Bruneval, Jérôme Larghero, Onnik Agbulut, Philippe Menasché,
à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2014 - Elsevier BV | The Journal of Heart and Lung Transplantation
Simon Boitard, Robert Kofler, Pierre Françoise, David Robelin, Christian Schlötterer, Andreas Futschik,
Abstract Due to its cost effectiveness, next generation sequencing of pools of individuals (Pool‐Seq) is becoming a popular strategy for genome‐wide estimation of allele frequencies in population samples. As the allele frequency spectrum provides information about past episodes of selection, Pool‐seq is also a promising design for genomic scans for selection. However, no software tool has yet been developed for selection scans based on Pool‐Seq data. We introduce Pool‐hmm, a Python program for the ...
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2013 - Wiley | Molecular Ecology Resources
Cécile Teinturier, M F Tournade, Sophie Caillat‐Zucman, Christian Boîtard, Zahir Amoura, Pierre-François Bougnères, José Timsit,
Tópico(s): Cancer, Hypoxia, and Metabolism
1995 - Elsevier BV | The Lancet
Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Mohammad Alhadj Ali, Colin Dayan, Bart Keymeulen, Katharine R. Owen, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Roxana Roohi Ahangarani, Evelien Gebruers, Nicolas Bovy, Luc VanderElst, Marcelle Van Mechelen, Pierre Vandepapelière, Christian Boîtard,
Abstract Background Type 1 diabetes (T1D) is a CD4 + T cell-driven autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells by CD8 + T cells. Achieving glycemic targets in T1D remains challenging in clinical practice; new treatments aim to halt autoimmunity and prolong β-cell survival. IMCY-0098 is a peptide derived from human proinsulin that contains a thiol-disulfide oxidoreductase motif at the N-terminus and was developed to halt disease progression by promoting ...
Tópico(s): Pancreatic function and diabetes
2023 - BioMed Central | BMC Medicine
L. Castano, Christian Boîtard, Pierre-François Bougnères,
Tópico(s): Diabetes Management and Research
1988 - American Diabetes Association | Diabetes
Sophie Caillat‐Zucman, H.‐J. Garchon, José Timsit, R Assan, Christian Boîtard, Idriss Djilali-Saiah, Pierre Bougnères, Jean‐François Bach,
The association of insulin-dependent diabetes mellitus (IDDM) with certain HLA alleles is well documented in pediatric patients. Whether a similar association is found in adult-on-set IDDM is not clear, although the disease occurs after the age of 20 in 50% of cases. HLA class II DRB1, DQA1, and DQB1 alleles were studied in 402 type I diabetics and 405 healthy controls (all Caucasian) using oligonucleotide typing after gene amplification. Alleles DRB1*03, DRB1*04, DQB1*0201, DQB1*0302, DQA1*0301, ...
Tópico(s): Diabetes Management and Research
1992 - American Society for Clinical Investigation | Journal of Clinical Investigation
Thierry Hannedouche, M. Bajén Lázaro, Alvimar G. Delgado, Christian Boîtard, Bernard Lacour, Jean‐Pierre Grünfeld,
1. A sustained high glomerular filtration rate in diabetes mellitus is associated with increased proximal reabsorption, suggesting alterations in the tubulo-glomerular feedback system. To test this hypothesis, renal function was studied in eight control subjects and 14 recent-onset euglycaemic insulin-dependent diabetic patients before and after infusion of the carbonic anhydrase inhibitor, acetazolamide (5 mg/kg body weight). 2. Acetazolamide induced a dramatic fall in glomerular filtration rate ...
Tópico(s): Hyperglycemia and glycemic control in critically ill and hospitalized patients
1991 - Portland Press | Clinical Science
Thierry Hannedouche, Alvimar G. Delgado, D.A. Gnionsahe, Christian Boîtard, Bernard Lacour, Jean-Pierre Grünfeld,
To investigate mechanisms underlying GFR control in diabetes mellitus, renal hemodynamics and segmental tubular handling of sodium, using lithium clearance, were assessed in 41 insulin-dependent diabetics (IDD) treated by insulin for 11 +/- 8 days, and in 19 normal controls. Average GFR and effective renal plasma flow (ERPF) were slightly but not significantly higher (136 +/- 22 vs. 123 +/- 16 ml/min.1.73 m2) in IDD than in normal subjects. GFR and ERPF were positively and strongly correlated in controls (r = 0.61, ...
Tópico(s): Dialysis and Renal Disease Management
1990 - Elsevier BV | Kidney International
Karine Clément, Catherine Le Stunff, Aline Meirhaeghe, Agnès Dechartres, Jean Ferrières, Arnaud Basdevant, Christian Boîtard, Philippe Amouyel, Pierre Bougnères,
We recently reported that rs361072, a promoter C/T variant of p110β, the catalytic subunit of PI3-kinase, was associated with a protection from insulin resistance (IR) in Caucasian adolescents in proportion of their body mass. We tested if this cis-regulatory QTL is associated with IR and type 2 diabetes in 7885 middle-aged obese and non-obese adults of European ancestry. We genotyped rs361072 in 1139 non-diabetic obese (NDO) European adults, in whom IR was estimated by the HOMA-IR index. We also ...
Tópico(s): Metabolism, Diabetes, and Cancer
2008 - Elsevier BV | Molecular Genetics and Metabolism
Laurent Castéra, Cédric Laouénan, Anaı̈s Vallet-Pichard, Tiphaine Vidal-Trécan, Pauline Manchon, Valérie Paradis, Dominique Roulot, Nathalie Gault, Christian Boîtard, Benoît Terris, H. Bihan, Jean‐Baptiste Julla, A. Radu, Thierry Poynard, Angélique Brzustowsky, Étienne Larger, Sébastien Czernichow, Stanislas Pol, Pierre Bédossa, Dominique Valla, Jean‐François Gautier, Christophe Junot, Bernard E. Van Beers, Christian Boîtard, Nathalie de Préville, Isabelle Durand‐Zaleski, Pierre‐Emmanuel Rautou, Marco Dioguardi, Valérie Vilgrain, Jean‐Pierre Riveline,
OBJECTIVE Most people with type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH) or advanced fibrosis (AF) remain undiagnosed, resulting in missed opportunities for early intervention. This multicenter, prospective study assessed the yield of using routinely available data to identify these patients. RESEARCH DESIGN AND METHODS A total of 713 outpatients with T2DM, screened in four diabetology clinics for nonalcoholic fatty liver disease according to American Diabetes Association criteria, ...
Tópico(s): Liver Disease and Transplantation
2023 - American Diabetes Association | Diabetes Care
Frédéric Tantot, Shauna L. Parkes, Alain R. Marchand, Chloé Boitard, Fabien Naneix, Sophie Layé, Pierre Trifilieff, Étienne Coutureau, Guillaume Ferreira,
Evidence now indicates that the chronic consumption of high-calorie foods, such as a high-fat diet (HFD), is associated with impaired control over food-seeking, yet the extent of this alteration is not fully understood. Using different reinforcement schedules, we evaluated whether HFD intake from weaning to adulthood modifies instrumental responding and induces a shift from goal-directed actions to habitual responding. We first observed reduced instrumental performance and motivation for a food reward ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2016 - Elsevier BV | Appetite
M Debray-Sachs, Claude Carnaud, Christian Boîtard, Hélène Cohen, Ion Gresser, Pierre Bédossa, Jean‐François Bach,
The NOD mouse is studied as an animal model of human insulin-dependent diabetes mellitus (IDDM). To evaluate the role of IFNγ in the pathogenesis of the disease, we have studied the effect of anti-IFNγ mAb on the expression of insulitis and clinical diabetes. Treatment of mice with manti-IFNγ mAb prevented the induction of early IDDM by cyclophosphamide as well as the adoptive transfer of diabetes by spleen cells from diabetic NOD mice. The protection against induction of diabetes by cyclophosphamide ...
Tópico(s): Diabetes Management and Research
1991 - Elsevier BV | Journal of Autoimmunity
Thierry Hannedouche, L. Pons Marqués, S Natov, Alvimar G. Delgado, Christian Boîtard, Bernard Lacour, Jean‐Pierre Grünfeld,
To assess the effects of genetic predisposition of essential hypertension on early renal function in recent insulin-dependent diabetics, we studied inulin, para-aminohippuric, sodium, and lithium clearances in 69 unselected diabetics with (n = 20) and without (n = 49) a family history of essential hypertension. Despite similar metabolic control, glomerular filtration rate and mean arterial pressure were significantly higher in diabetics with than in those without a family history of hypertension. However, ...
Tópico(s): Apelin-related biomedical research
1992 - Lippincott Williams & Wilkins | Hypertension
Karen Soussan, Eric Dausse, Thierry Hannedouche, José Timsit, Florence Lemoult, Christian Boîtard, Jean‐Pierre Grünfeld, Pascale Guicheney,
To investigate whether constitutive alterations of the Na+ / H+ antiport or of cell proliferation control mechanisms are implicated in development of nephropathy in insulin-dependent diabetics (IDD), skin fibroblasts from controls, recent-onset IDD with normal or high glomerular filtration rates, and IDD with proteinuria were cultured by explant technique. The Na+ / H+ antiport activity was studied using the pH sensitive fluorescent dye BCECF. The cell growth capacity was investigated by determination ...
Tópico(s): Birth, Development, and Health
1993 - Oxford University Press | American Journal of Hypertension
Sandrine Baron, Emeline Larvor, Éric Jouy, Isabelle Kempf, Sophie Le Bouquin, Claire Chauvin, Pierre‐Marie Boitard, Matthieu Jamin, Alain Breton, Benoît Thuillier, Peter Smith,
Abstract Standard disc diffusion and MIC test procedure were used to investigate the susceptibility of two hundred and fifty‐one isolates collected from infected fish in France to florfenicol, oxolinic acid and tetracycline. The tests were performed at 22 ± 2℃ and for the 177 Yersinia rucker i they were read after 24–28 hr incubation and for the 74 Aeromonas salmonicida isolates they were read after 44–48 hr. Applying epidemiological cut‐off values to the susceptibility data generated in these tests, ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2021 - Wiley | Journal of Fish Diseases
Jean‐Claude Carel, Christian Boîtard, George S. Eisenbarth, Jean-François Bach, Pierre-François Bougnères,
We conducted a pilot study of immunosuppression with low dose cyclosporine in first degree relatives of diabetic patients with immunologic and metabolic criteria for preclinical diabetes: islet cell antibodies (ICA) ≥20 Juvenile Diabetes Foundation (JDF) units, first phase insulin response 34±8 months,P<0.001 vs the control group; Mann–Whitney test). First phase insulin response increased to normal values in two patients. These results suggest that reversible functional impairment, in association with ...
Tópico(s): Diabetes Treatment and Management
1996 - Elsevier BV | Journal of Autoimmunity
Danièle Goldberg, Patricia Morel, Lucienne Chatenoud, Christian Boîtard, C J Menkès, P Bertoye, Jean‐Pierre Revillard, Jean‐François Bach,
A phase III trial of the anti-CD4 monoclonal antibody (mAb) was under-taken in seven rheumatoid arthritis patients in order, (1) to investigate changes in clinical symptoms and possible side effects, and (2) to study the pharmacokinetics and to determine the dose required to achieve saturation of antibody binding sites on blood leucocytes. BL4 mAb is a murine IgG2a which binds to the group 2B epitope of the V1 N terminal domain of the CD4 molecule. It inhibits syncitium formation by human immunodeficiency ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
1991 - Elsevier BV | Journal of Autoimmunity
Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Nicolas Bovy, Luc VanderElst, Marcelle Van Mechelen, Pierre Vandepapelière, Christian Boîtard,
IMCY-0098, a synthetic peptide developed to halt disease progression via elimination of key immune cells in the autoimmune cascade, has shown a promising safety profile for the treatment of type 1 diabetes (T1D) in a recent phase 1b trial. This exploratory analysis of data from that trial aimed to identify the patient biomarkers at baseline associated with a positive response to treatment and examined the associations between immune response parameters and clinical efficacy endpoints (as surrogates ...
Tópico(s): Immune Cell Function and Interaction
2024 - BioMed Central | BMC Medicine
Alexandre Louvet, J. Boitard, Sébastien Dharancy, Arnaud Duriez, Pierre Deltenre, Jean-Claude Paris, Philippe Mathurin,
Tópico(s): Pharmacological Effects of Natural Compounds
2006 - Elsevier BV | Gastroentérologie Clinique et Biologique
Μαρία Κιτσαρά, Pierre Joanne, Solène Emmanuelle Boitard, Ibtihel Ben Dhiab, Barbara Poinard, Philippe Menasché, Christian H. Gagnieu, Patricia Forest, Onnik Agbulut, Yong Chen,
Synergy between micro-nanotechnology and regenerative medicine can lead to new tools for health improvement. In this study, we investigate the efficacy of electrospun scaffolds – fabricated using clinically approved collagen – as supports for cardiomyoblast culture. The scaffolds were prepared using non-toxic solvents and crosslinking agents and characterized by scanning electron microscopy and contact angle measurements. Among different types of collagen samples, we found that atelocollagen can produce ...
Tópico(s): Bone Tissue Engineering Materials
2015 - Elsevier BV | Microelectronic Engineering
... nouvelle littérature. Au sein du Musée des familles, Pierre Boitard a ainsi été chargé de la rédaction de ...
Tópico(s): French Urban and Social Studies
2020 - | Arts et Savoirs
Hadhami Hamdi, Solène Emmanuelle Boitard, Valérie Planat‐Bénard, Julia Pouly, Hany Neamatalla, Pierre Joanne, Marie-Cécile Perier, Valérie Bellamy, Louis Casteilla, Zhenlin Li, Albert Hagège, Mathias Mericskay, Philippe Menasché, Onnik Agbulut,
Few studies have assessed the effects of cell therapy in non-ischaemic cardiomyopathies which, however, contribute to a large number of cardiac failures. Assuming that such conditions are best suited for a global delivery of cells, we assessed the effects of epicardially delivered adipose tissue-derived stroma cell (ADSC) sheets in a mouse model of dilated cardiomyopathy based on cardiac-specific and tamoxifen-inducible invalidation of serum response factor. Three weeks after tamoxifen administration, ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2013 - Oxford University Press | Cardiovascular Research
Pierre‐François Roux, Simon Boitard, Yuna Blum, Brian W. Parks, Alexandra Montagner, Étienne Mouisel, Anis Djari, Diane Esquerré, Colette Désert, Morgane Boutin, Sophie Leroux, Frédéric Lecerf, Elisabeth Le Bihan-Duval, Christophe Klopp, Bertrand Servin, Frédérique Pitel, Michel Jacques M.J. Duclos, Hervé Guillou, Aldons J. Lusis, Olivier Demeure, Sandrine Lagarrigue,
Very few causal genes have been identified by quantitative trait loci (QTL) mapping because of the large size of QTL, and most of them were identified thanks to functional links already known with the targeted phenotype. Here, we propose to combine selection signature detection, coding SNP annotation, and cis-expression QTL analyses to identify potential causal genes underlying QTL identified in divergent line designs. As a model, we chose experimental chicken lines divergently selected for only ...
Tópico(s): Plant Molecular Biology Research
2015 - Genetics Society of America | G3 Genes Genomes Genetics