Thomas Foster, Nigel De Gruchy, Abdulkadir Mohamoud Issa, A. Thyagaraja, Eldon Griffiths, I. Cook, Justin Sweet, S. Stone, S.J. Foster, W. Ritchie, Antony Flew, Jack H. Morris,
... firms Backlash Kennecott/Curtiss-Wright IBM Livingston The Pierre Trust Houses Forte (THF) IESE University of Navarra ...
1980 - Gale Group | The Economist
... between aberrant DNA methylation and aging, says Jean-Pierre Issa, a professor of medicine at The University of ... critical and feasible.Epigenetics, says cancer biologist Jean-Pierre Issa of The University of Texas M.D. Anderson ...
Tópico(s): Health, Environment, Cognitive Aging
2006 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Alan F. List, James W. Vardiman, Jean‐Pierre J. Issa, Theo deWitte,
... molecule, selective therapeutics. In Section III, Dr. Jean-Pierre Issa provides an overview of epigenetic events regulating gene ...
Tópico(s): Histone Deacetylase Inhibitors Research
2004 - American Society of Hematology | Hematology
Catherine Arnold, K. L. Barlow, Steve Kaye, Clive Loveday, Peter Balfe, Jonathan P. Clewley,
... Richard Onanga, Feng Gao, Maria Makuwa, Paul Ngari, Issa Bedjabaga, Pierre Roques, François Simon, and Cristian Apetrei5 July 2004 | ...
Tópico(s): Cytomegalovirus and herpesvirus research
1995 - Mary Ann Liebert, Inc. | AIDS Research and Human Retroviruses
Michael J. Overman, Van K. Morris, Helen Moinova, Ganiraju C. Manyam, Joe Ensor, Michael S. Lee, Cathy Eng, Bryan K. Kee, David R. Fogelman, Rachna T. Shroff, Thomas LaFramboise, Thibault Mazard, Feng Tian, Stanley R. Hamilton, Bradley M. Broom, James Lutterbaugh, Jean‐Pierre J. Issa, Sanford D. Markowitz, Scott Kopetz,
... 7 , Bradley Broom 6 , James Lutterbaugh 2 , Jean-Pierre Issa 5 , Sanford D. Markowitz 2 and Scott Kopetz ...
Tópico(s): Colorectal Cancer Treatments and Studies
2016 - Impact Journals LLC | Oncotarget
David Choi, Syamalima Dube, TIMOTHY P. SPICER, Herbert B. Slade, Fred C. Jensen, Bernard J. Poiesz,
... Richard Onanga, Feng Gao, Maria Makuwa, Paul Ngari, Issa Bedjabaga, Pierre Roques, François Simon, and Cristian Apetrei5 July 2004 | ...
Tópico(s): Bacteriophages and microbial interactions
1997 - Mary Ann Liebert, Inc. | AIDS Research and Human Retroviruses
Nathan Mottal, N. Issa, Pierre‐Yves Dumas, Fabrice Camou, Mathieu Sauvezie, François‐Xavier Gros, Titouan Cazaubiel, Gaëlle Mourissoux, Harmony Leroy, Arnaud Pigneux, Olivier Guisset, Thibaut Leguay,
Patients presenting with acute myeloid leukemia (AML) at diagnosis are at high risk of severe complications and death, particularly with high white blood cell (WBC) count. In this retrospective study, we evaluate interest of early and systematic support in the intensive care unit (ICU) for AML with hyperleukocytosis (AML-HL) at diagnosis.Patients with AML-HL, defined by WBC > 50 × 109/L, primary referred in ICU ("Early ICU") without organ failure and before initiating chemotherapy induction were compared ...
Tópico(s): Hematological disorders and diagnostics
2020 - | Journal of Hematology
Subhi Issa, Pierre-Henri Paris, Fayçal Hamdi, Samira Si-Saïd Cherfi,
RDF-based datasets, thanks to their semantic richness, variety and fine granularity, are increasingly used by both researchers and business communities. However, these datasets suffer a lack of completeness as the content evolves continuously and data contributors are loosely constrained by the vocabularies and schemes related to the data sources. Conceptual schemas have long been recognized as a key mechanism for understanding and dealing with complex real-world systems. In the context of the Web ...
Tópico(s): Data Mining Algorithms and Applications
2019 - Springer Science+Business Media | Lecture notes in computer science
Ivona Pandrea, David L. Robertson, Richard Onanga, Feng Gao, Maria Makuwa, Paul Ngari, Issa Bedjabaga, Pierre Roques, François Simon, Cristian Apetrei,
Forty-one HIV-1 strains from Gabonese patients were studied according to the following strategy: nested polymerase chain reaction were performed to obtain an approximately 1100-bp fragment containing the protease gene and the 5′ half of the reverse transcriptase gene. Additional amplifications were carried out to obtain an approximately 700-bp fragment encompassing the C2V3 env gene. Fragments of 600 to 1200 bp in the gag gene overlapping the pol sequences were used for the study of recombination ...
Tópico(s): HIV/AIDS Research and Interventions
2002 - Mary Ann Liebert, Inc. | AIDS Research and Human Retroviruses
Corine Vernet, Marie-Th�r�se Ribouchon, Giovanna Chimini, Anne‐Marie Jouanolle, Issa Sidib�, Pierre Pontarotti,
Tópico(s): Immune Cell Function and Interaction
1993 - Springer Science+Business Media | Immunogenetics
Samir-Pierre Issa, César Payán‐Gómez, Malo Le Hanneur, P. Loriaut, Patrick Boyer,
Double-button devices for endoscopic management of acute acromioclavicular joint dislocation (ACJD) provide satisfactory short-term functional and radiological results. However, little exists in the literature regarding the long- and medium-term results of these implants, especially regarding the evolution of the acromioclavicular joint (ACJ). Satisfactory and steady long- and medium-term outcomes can be achieved in patients with acute ACJD undergoing endoscopically assisted ACJ repair using a single ...
Tópico(s): Trauma Management and Diagnosis
2017 - Elsevier BV | Orthopaedics & Traumatology Surgery & Research
Alexandre Hardy, Romain Rousseau, Samir-Pierre Issa, Antoine Gérometta, Hugues Pascal‐Moussellard, Benjamin Granger, F. Khiami,
Insertional Achilles tendinopathy is a generic term that encompasses several types of ailments. While conservative treatment is less effective than for conditions isolated to the tendon body, there is no consensus as to the best type of surgical care.Surgical treatment for insertional Achilles tendinopathy that is tailored to the severity of the tendon involvement will lead to satisfactory functional outcomes.Forty-six patients were included with an average age of 44.1±11.4 years and a mean preoperative ...
Tópico(s): Foot and Ankle Surgery
2018 - Elsevier BV | Orthopaedics & Traumatology Surgery & Research
Mónica Rosas Lemus, Elodie Roussarie, Noureddine Hammad, Alexis Mougeolle, Stéphane Ransac, Razanne Issa, Jean-Pierre Mazat, Salvador Uribe‐Carvajal, Michel Rigoulet, Anne Devin,
Evidence for the Crabtree effect was first reported by H. Crabtree in 1929 and is defined as the glucose-induced decrease of cellular respiratory flux. This effect was observed in tumor cells and was not detected in most non-tumor cells. A number of hypotheses on the mechanism underlying the Crabtree effect have been formulated. However, to this day, no consensual mechanism for this effect has been described. In a previous study on isolated mitochondria, we have proposed that fructose-1,6-bisphosphate ( ...
Tópico(s): Molecular Communication and Nanonetworks
2018 - Elsevier BV | Journal of Biological Chemistry
Samir-Pierre Issa, David Biau, A. Babinet, Valérie Dumaine, Malo Le Hanneur, Philippe Anract,
Despite numerous reconstructive techniques and prosthetic devices, pelvic reconstructions following peri-acetabular malignant tumours resections are highly challenging. In the present study, we describe our experience with the Integra® (Lépine, Genay, France) ice-cream cone prosthesis in such indications. The objective was to assess the mid-term outcomes of this device. Twenty-four patients' chart with peri-acetabular malignant tumours, who underwent types II or II + III peri-acetabular resections ...
Tópico(s): Oral and Maxillofacial Pathology
2018 - Springer Science+Business Media | International Orthopaedics
James N. Lowder, Pietro Taverna, Jean‐Pierre J. Issa,
... Drive, Suite 200, Pleasanton, CA 92488, USA & Jean-Pierre J Issa Fels Institute, Temple University School of Medicine & Cancer ...
Tópico(s): Histone Deacetylase Inhibitors Research
2015 - Future Medicine | Epigenomics
Jean‐Philippe Foy, Curtis R. Pickering, Vassiliki A. Papadimitrakopoulou, Jaroslav Jelı́nek, Steven H. Lin, William Nassib William, Mitchell J. Frederick, Jing Wang, Wenhua Lang, Lei Feng, Li Zhang, Edward S. Kim, You Hong Fan, Waun Ki Hong, Adel K. El‐Naggar, J. Jack Lee, Jeffrey N. Myers, Jean‐Pierre J. Issa, Scott M. Lippman, Li Mao, Pierre Saintigny,
DNA promoter methylation of tumor suppressor genes and global DNA hypomethylation are common features of head and neck cancers. Our goal was to identify early DNA methylation changes in oral premalignant lesions (OPL) that may serve as predictive markers of developing oral squamous cell carcinoma (OSCC). Using high-throughput DNA methylation profiles of 24 OPLs, we found that the top 86 genes differentially methylated between patients who did or did not develop OSCC were simultaneously hypermethylated, ...
Tópico(s): Cancer-related gene regulation
2015 - American Association for Cancer Research | Cancer Prevention Research
Subhi Issa, Pierre-Henri Paris, Fayçal Hamdi,
RDF web datasets, thanks to their semantic richness, variety and fine granularity, are increasingly adopted by both researchers' and business communities. However, as anyone can publish data, this leads to sparse and heterogeneous data descriptions with undeniably an impact on quality. Consequently, there is an increasing effort dedicated to Web data quality improvement. We are interested in data quality and precisely in completeness quality evolution over time. The paper presents a set of experiments ...
Tópico(s): Advanced Database Systems and Queries
2017 - Springer Science+Business Media | Lecture notes in computer science
Gail J. Roboz, Hartmut Döhner, Marco Gobbi, Patricia Kropf, Jiřı́ Mayer, Jürgen Krauter, Tadeusz Robak, Hagop M. Kantarjian, Jan Novák, W Wiktor-Jędrzejczak, Xavier Thomas, Mario Ojeda‐Uribe, Yasushi Miyazaki, Yoo Hong Min, Su‐Peng Yeh, Joseph Brandwein, Liana Gercheva, Judit Demeter, Elizabeth A. Griffiths, Karen Yee, Jean‐Pierre J. Issa, Yong Hao, Mohammad Azab, Pierre Fenaux,
Background: Guadecitabine (G) is a next generation subcutaneous (SC) hypomethylating agent (HMA) resistant to degradation by cytidine deaminase which results in prolonged in vivo exposure to the active metabolite decitabine. We conducted a large global randomized phase 3 study of G vs Treatment Choice (TC) with azacitidine (AZA), decitabine (DEC), or low dose Ara-C (LDAC) in 815 TN AML patients unfit for IC (ASTRAL-1 study). The primary ITT results were previously presented (Fenaux et al, EHA abstract S879, ...
Tópico(s): Epigenetics and DNA Methylation
2019 - Elsevier BV | Blood
Abdoul Karim Sakira, Corenthin Mees, Kris De Braekeleer, Cédric Delporte, Josias YAMEOGO, Moussa Yabré, Touridomon Issa Somé, Pierre Van Antwerpen, Dominique Mertens, Jean Michel Kauffmann,
In the quality control of medicines and the fight against the phenomenon of poor quality medicines, there is an urgent need for rapid and broad spectrum methods for screening these types of medicines. In the present work, we have used near infrared spectroscopy combined with multivariate data analysis to develop chemometric models for the classification and quantification of metronidazole in Burkina Faso pharmaceutical formulations. For this purpose, drug samples were collected in drugstores located ...
Tópico(s): Pesticide Residue Analysis and Safety
2020 - Elsevier BV | Talanta Open
Jean Issa, Pierre Lodewyckx, Hélène Blasco, Isabelle Benz‐de Bretagne, F. Labarthe, Bruno Lefort,
Heart failure in adults is characterized by reduction of long-chain fatty acid oxidation in favour of carbohydrate metabolism. This adaptive phenomenon becomes maladaptive because energy conversion decreases and lipid toxic derivatives known to impair cardiac function are accumulating. No data are available concerning metabolic modification in heart failure in children.In order to evaluate the fatty acid oxidation in children suffering from heart failure, acylcarnitine profiles on dried blood spots ...
Tópico(s): Mitochondrial Function and Pathology
2023 - Wiley | ESC Heart Failure
Yasuhiro Oki, Jean‐Pierre J. Issa,
Epigenetics refers to a stable, mitotically perpetuated regulatory mechanism of gene expression without an alteration of the coding sequence. Epigenetic mechanisms include DNA methylation and histone tail modifications. Epigenetic regulation is part of physiologic development and becomes abnormal in neoplasia, where silencing of critical genes by DNA methylation or histone deacetylation can contribute to leukemogenesis as an alternative to deletion or loss-of-function mutation. In acute myelogenous ...
Tópico(s): Acute Myeloid Leukemia Research
2009 - Springer Science+Business Media | Cancer treatment and research
Mi-Jung Kim, Jill A White-Cross, Lanlan Shen, Jean‐Pierre J. Issa, Asif Rashid,
Recent studies have revealed the epigenetic alterations are involved in hepatocarcinogenesis. However, the function of long interspersed nuclear element-1 hypomethylation in hepatocellular carcinomas, and relationship among other clinicopathologic features, and genetic and epigenetic alterations, including CpG island hypermethylation, have not been studied. We determined long interspersed nuclear element-1 methylation, a marker of global methylation, in 57 tumor and nonneoplastic samples, including ...
Tópico(s): RNA modifications and cancer
2009 - Elsevier BV | Modern Pathology
Xuelin Huang, Jing Ning, Yisheng Li, Elihu H. Estey, Jean‐Pierre J. Issa, Donald A. Berry,
Abstract Increased survival is a common goal of cancer clinical trials. Owing to the long periods of observation and follow‐up to assess patient survival outcome, it is difficult to use outcome‐adaptive randomization in these trials. In practice, often information about a short‐term response is quickly available during or shortly after treatment, and this short‐term response is a good predictor for long‐term survival. For example, complete remission of leukemia can be achieved and measured after ...
Tópico(s): Statistical Methods and Inference
2009 - Wiley | Statistics in Medicine
Gautam Borthakur, Xuelin Huang, Hagop M. Kantarjian, Stefan Faderl, Farhad Ravandi, Alessandra Ferrajoli, Ritva Torma, Gail Morris, Donald A. Berry, Jean‐Pierre J. Issa,
Cytarabine resistance characterizes relapsed and refractory acute myelogenous leukemia (AML). Restoration of cytarabine sensitivity can potentially improve treatment outcome in this setting. Acquired hypermethylation of gene promoters and associated silencing of gene expression has been implicated in chemo resistance, and drug-induced hypomethylation can improve sensitivity to cytarabine in vitro. We conducted an adaptively randomized study of a combination of azacitidine, a hypomethylating agent, ...
Tópico(s): Acute Lymphoblastic Leukemia research
2009 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Ana M. Aparicio, Brittany North, Lindsey Barske, Xuemei Wang, Valentina Bollati, Daniel J. Weisenberger, Christine B. Yoo, Nizar M. Tannir, E. Horne, Susan Groshen, Peter M. Jones, Allen S. Yang, Jean‐Pierre J. Issa,
Multiple clinical trials are investigating the use of the DNA methylation inhibitors azacitidine and decitabine for the treatment of solid tumors. Clinical trials in hematological malignancies have shown that optimal activity does not occur at their maximum tolerated doses but selection of an optimal biological dose and schedule for use in solid tumor patients is hampered by the difficulty of obtaining tumor tissue to measure their activity. Here we investigate the feasibility of using plasma DNA ...
Tópico(s): RNA modifications and cancer
2009 - Landes Bioscience | Epigenetics
Carol B. Ware, Linlin Wang, Brigham H. Mecham, Lanlan Shen, Angelique M. Nelson, Merav Bar, Deepak A. Lamba, Derek S. Dauphin, Brian P. Buckingham, Bardia Askari, Raymond S. Lim, Muneesh Tewari, Stanley M. Gartler, Jean‐Pierre J. Issa, Paul Pavlidis, Zhijun Duan, C. Anthony Blau,
Recent evidence indicates that mouse and human embryonic stem cells (ESCs) are fixed at different developmental stages, with the former positioned earlier. We show that a narrow concentration of the naturally occurring short-chain fatty acid, sodium butyrate, supports the extensive self-renewal of mouse and human ESCs, while promoting their convergence toward an intermediate stem cell state. In response to butyrate, human ESCs regress to an earlier developmental stage characterized by a gene expression ...
Tópico(s): Epigenetics and DNA Methylation
2009 - Elsevier BV | Cell stem cell
Mark Kirschbaum, Ivana Gojo, Stuart L. Goldberg, Lisa Kujawski, Ehab Atallah, Peter Marks, Donna Di Gravio, Lisa Pyle, Syed Rizvi, Jean‐Pierre J. Issa,
Abstract Abstract 2089 Poster Board II-66 Introduction: Although the introduction of epigenetic therapies, such as the DNA methyltransferase inhibitor (DNMT) decitabine, has improved options for the treatment of myeloid malignancies, use is limited by sub-optimal response rates. Therefore, there remains a need for more effective treatment strategies to improve outcomes in AML/MDS. Preclinical and clinical data suggest that broadening epigenetic targeting by adding histone deacetylase (HDAC) inhibitors ...
Tópico(s): Protein Degradation and Inhibitors
2009 - Elsevier BV | Blood
Yasuhiro Gotô, Keiko Shinjo, Yutaka Kondo, Lanlan Shen, Minoru Toyota, Hiromu Suzuki, Wentao Gao, Byonggu An, Makiko Fujii, Hideki Murakami, Hirotaka Osada, Tetsuo Taniguchi, Noriyasu Usami, Masashi Kondo, Yoshinori Hasegawa, Kaoru Shimokata, Keitaro Matsuo, Toyoaki Hida, Nobukazu Fujimoto, Takumi Kishimoto, Jean‐Pierre J. Issa, Yoshitaka Sekido,
Malignant pleural mesothelioma (MPM) is a fatal thoracic malignancy, the epigenetics of which are poorly defined. We performed high-throughput methylation analysis covering 6,157 CpG islands in 20 MPMs and 20 lung adenocarcinomas. Newly identified genes were further analyzed in 50 MPMs and 56 adenocarcinomas via quantitative methylation-specific PCR. Targets of histone H3 lysine 27 trimethylation (H3K27me3) and genetic alterations were also assessed in MPM cells by chromatin immunoprecipitation arrays ...
Tópico(s): Epigenetics and DNA Methylation
2009 - American Association for Cancer Research | Cancer Research
Stefan Heinrichs, Rima V. Kulkarni, Carlos E. Bueso‐Ramos, Ross L. Levine, Mignon L. Loh, Chaofan Li, Donna Neuberg, Steven M. Kornblau, Jean‐Pierre J. Issa, D. Gary Gilliland, Guillermo Garcia‐Manero, Hagop M. Kantarjian, Elihu H. Estey, A. Thomas Look,
Progress in the management of patients with myelodysplastic syndromes (MDS) has been hampered by the inability to detect cytogenetic abnormalities in 40–60% of cases. We prospectively analyzed matched pairs of bone marrow and buccal cell (normal) DNA samples from 51 MDS patients by single nucleotide polymorphism (SNP) arrays, and identified somatically acquired clonal genomic abnormalities in 21 patients (41%). Among the 33 patients with normal bone marrow cell karyotypes, 5 (15%) had clonal, somatically ...
Tópico(s): Cancer Genomics and Diagnostics
2009 - Springer Nature | Leukemia
Hagop M. Kantarjian, Susan O’Brien, Farhad Ravandi, Gautam Borthakur, Stefan Faderl, Carlos E. Bueso‐Ramos, Lynne V. Abruzzo, Sherry Pierce, Jianqin Shan, Jean‐Pierre J. Issa, Guillermo Garcia‐Manero,
To define the prognosis in myelodysplastic syndrome (MDS) and deletion 5q with or without other cytogenetic abnormalities.Patients with MDS ( or =2 abnormalities or chromosome 7 abnormality. Only 93 patients (3.4% of total) had lower risk MDS (international prognostic scoring system low or intermediate 1) and deletion 5q; their median survival was 29 months (2-year survival 60%), and ranged from 13-41 months depending on the presence or absence of additional chromosomal abnormalities. Among 198 patients ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2009 - Wiley | Cancer