H. M. Cohen, Chas. T. Souther, Thomas W. Blackburn, John D. Spelman, Louis J. Krouse, G. A. Hinnen, Hugh W. M'Millan, Carl Hiller, Irving David Steinhardt,
... Congenital Absence of Both Ears, Abscess Originating in Pilo-Nidal Sinus, Departments Anesthesia, Military Medicine, The Mission ...
1914 - Gale Group | NCCO-STM 1of2
Produção Nacional
Revisado por pares
Beatriz M. Longo, E Sanabria, Siegrun Gabriel, Luiz E. Mello,
... of the hippocampus in the CHX/pilocarpine (CHX/PILO) model as compared with the conventional PILO model. Methods: In vitro electrophysiology was performed 2 ... induction using extracellular recordings in hippocampal slices from PILO (n = 8) and CHX/PILO animals (n = 10). Field potential responses were evoked ... assessment of supragranular MFS. Results: Evoked potentials in PILO‐ and CHX/PILO‐treated rats displayed small‐amplitude polyspiking activity (epileptiform ... normal isolated population spike in DG. More important, PILO and CHX/PILO animals did not differ regarding ...
Tópico(s): Epilepsy research and treatment
2002 - Wiley | Epilepsia
Joseph Ransohoff, J. H. Kellogg, Fletcher Hodges, Mark A. Brown, Samuel E. Allen, F. O. Marsh, J. W. Thiel, Wm. E. DeCOURCY,
... of the Stomach from the Surgeon's Viewpoint, Pilo-Nidal Cysts and Sinuses, Correspondence "The Over-Trained ...
1906 - Gale Group | NCCO-STM 1of2
Philip A. Williams, Jean‐Pierre Wuarin, Ping Dou, Damien Ferraro, F. Edward Dudek,
... prevents Timm staining in the IML following pilocarpine (PILO)-induced status epilepticus (a multifocal model of temporal ... seizures) after a latent period. Hippocampal slices from PILO-treated rats without Timm stain in the IML ... kg) 30-45 min prior to administration of PILO (320 mg/kg ip, 2) only PILO, and 3) only saline (0.5 ml, IP). ... decreased the number of rats that responded to PILO with status epilepticus compared to rats that received only PILO. Pre-treatment with CHX did not significantly alter ...
Tópico(s): Memory and Neural Mechanisms
2002 - American Physiological Society | Journal of Neurophysiology
Andrew Robson, Gabriele Marcotti, Gabriel Rozenberg and Gary Duncan, Richard Whitehead, Matthew Syed, DJM, Richard Channon, Andrew Pierce, David Charter and Rajeev Syal, Anne Garvey, Tim Albone, Tanya Byron, Gary Duncan, Simon Barnes, Thomas Lee, Mark Souster, David Rhys Jones, Michael Evans Defence Editor, Philip Howard, Carol Midgley, Kathy White, Michael Simkins, Hilary Finch, Christine Seib, David Chater, Joanna Bale, James Bone, Paul Knight Director, Mick Snowden, Penny Wark, James Ducker, Alexandra Frean Social Affairs Correspondent, Carl Mortished, Alex Griffiths, Vicki Lavarack, Kevin Eason, Joe Joseph, Ben Webster Transport Correspondent, Pat Gibson, David McVay, Jane MacArtney, Angus Nicol Piping Correspondent, Jack Malvern, Tom Bawden, Debra Craine, Shirley English, Sam Younger, Rory Watson, Gary Jacob, Jana Bakunina, Candida Crewe, Stephen Farrell, David Sharrock Ireland Correspondent, Ellsworth Kelly, Scott Watson, Anatole Kaletsky, Phil Gordon, Keith Pike, David Hands, Colin Miller, Charles Bremner, Jonathan Richards, Ron Lewis, Matt Dickinson Chief Football Correspondent, Sholto Byrnes, Stefanie Marsh, Richard Gully, David Charter, Danny Kelly, Carl Mortished and Gary Duncan, Simon Fanshawe, Tony Halpin Education Editor, Oliver Kay, Dan Brennan, Neil Harman, Rick Broadbent, Julian Evans, Tom Baldwin, David Lawrenson, Pete Paphides, John Hopkins, Brian Hughes, Neil Harman Tennis Correspondent, Raymond Keene, Adam Sage, Matt Dickinson, Rebecca O'Connor, Sean O'Neill, Kaveh Solhekol, Jeremy Page, Chris Campling, Julian Margaret Gibbs, Richard Owen, Malcolm Bowden, Simon Tizard, Christopher Martin-Jenkins Chief Cricket Correspondent, Damian Whitworth, Peter Dixon, Nick Kelly, Dalya Alberge, David Hands Rugby Correspondent, Tom Dart, Adam Fresco, Frank Hamilton, Anne Ashworth, William Rees-Mogg, Tim Hames, Craig Lord, Anjana Ahuja, George Caulkin, Bruce Anderson, P. R. Banham, Caitlin Moran, Alan Lee, Walter Gammie, Dr Raphael Eban, Sarah Ebner, David Charter Chief Political Correspondent, Rajeev Syal, David Sanderson, Lewis Stuart, Peter Goodman, Martin Waller, Christopher Irvine, Lisa Verrico, James Jackson, Carl Mortished International Business Editor, Danny Baker, Nigel Hawkes Health Editor, Benedict Nightingale, Dr Thomas Stuttaford, Stephen Dalton, David Powell, Alyson Rudd, Bill Edgar, James Christopher, Tony Halpin, Jill Berliand, Owen Slot, Olav Bjortomt, Professor Ian Johnson, Chairman, Ukcat Dr Katie Petty-Saphon Executive director, Jenny Davey, Sam Lister Health Correspondent, Robin Estridge, Ian Carson, Peter Andell, Nick Meo, Joe Bolger,
... Cissé 52 (pen) Tireless Gerrard thriving despite fixture pilo-up Rangers Ready to Tempt Pires The News ...
2006 - Gale Group | TDA
Produção Nacional
Revisado por pares
Olagide Wagner de Castro, M.A. Furtado, Cristiane Queixa Tilelli, A. Fernandes, Gisela P. Pajolla, Norberto Garcia‐Cairasco,
... systemic (S) or intrahippocampal (H) injection of pilocarpine (PILO), two models of temporal lobe epilepsy (TLE), using ... the kinetics of FJ staining in the H-PILO model. Therefore, we measured the severity of behavioral ... and 168 h (7 days) after the H-PILO insult. We found that the amount of FJ- ... area was greater in SE induced by S-PILO as compared to SE induced by H-PILO. After SE induced by H-PILO, we found more FJ+ cells in the hilus ... acidic protein (GFAP) labeling 24 h after H-PILO demonstrated spatially selective neurodegeneration. Double labeling with FJ ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2010 - Elsevier BV | Brain Research
Jesse Hammond, Greville Brooke, James Sheridan Knowles Esq, Edward W. Topham,
... Co. Carlow) Races Foreign Summary Michtgan Washingtonian, Montreal Pilo, New York Inquirer, New York Herald: Horrible Occurrences ...
1846 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Igor Santana de Melo, Yngrid Mickaelli Oliveira dos Santos, Maisa Araújo Costa, Amanda Larissa Dias Pacheco, Nívea K.G.T. Silva, Léia Cardoso-Sousa, Ulises Pereira, Luíz Ricardo Goulart, Norberto Garcia‐Cairasco, Marcelo Duzzioni, Daniel Leite Góes Gitaí, Cristiane Queixa Tilelli, Robinson Sabino‐Silva, Olagide Wagner de Castro,
... of limbic seizures and neurodegeneration process after pilocarpine (PILO)-induced SE. Vehicle (VEH, 1 μL) or phlorizin, ... in the hippocampus of rats 30 min before PILO (VEH + PILO or PZN + PILO, respectively). The limbic seizures were classified using the ... 05) number of WDS when compared with VEH + PILO. There was no difference in seizure severity between PZN + PILO and VEH + PILO groups. However, the pattern of limbic seizures significantly changed in PZN + PILO. Indeed, the class 5 seizures repeated themselves more ...
Tópico(s): Drug Transport and Resistance Mechanisms
2016 - Elsevier BV | Epilepsy & Behavior
Dr. E. M. Buckingham, Dr. James C. White, Henry W. Williams, Charles F. Folsom, J. Collins Warren, Hasket Derby, C. Ellery Stedman, George A. Bethune, D. W. Cheever, F. W. Draper, R. M. Hodges, C. J. Blake, E. H. Bradford, Clifton E. Wing, E. S. Wood, J. H. Whittemore, William P. Bolles, John Homans, James J. Putnam,
... Daily Amount of Urine: Its Importance in Diagnosis, Pilo-Nidal Sinus, The Treatment of Irreducible Hernia, The ...
1883 - Gale Group | NCCO-STM 1of2
Tiffany L. Leighton, Daniel H. Yong, P. Lynne Howell, Lori L. Burrows,
... mutations encoding Cys substitutions into pilN and/or pilO on the chromosome to maintain normal stoichiometry and ... covalent PilNO heterodimers, as well as PilN and PilO homodimers, in vivo. Most covalent PilN or PilO homodimers had minimal functional impact in P. aeruginosa, ... soluble N-terminal truncated fragments of PilN and PilO Cys mutants, which purified as a mixture of ... T4P function depends on rearrangements at PilN and PilO interfaces. Pseudomonas aeruginosa is a leading cause of ... mutations encoding Cys substitutions into pilN and/or pilO on the chromosome to maintain normal stoichiometry and ...
Tópico(s): Bacterial Genetics and Biotechnology
2016 - Elsevier BV | Journal of Biological Chemistry
Pilocarpine (PILO), a muscarinic agonist, produces status epilepticus when administered to rats in vivo and induces interictal or ictal ... rat hippocampal slices. We investigated the effects of PILO (10 μM) on paired pulse inhibition (PPI) in ... the second stimulus was compared to the first, PILO was bath applied for 1 h and then ... out to assess acute and long lasting effects. PILO decreased the amplitude of evoked population spikes measured ... PPI following alveus stimulation was not affected by PILO; however, a significant loss of PPI at 15 ...
Tópico(s): Lipid Membrane Structure and Behavior
1997 - Elsevier BV | Brain Research
Produção Nacional
Revisado por pares
M.M.F. Marinho, Francisca Cléa Florenço de Sousa, Veralice Meireles Sales de Bruin, Mariana Lima Vale, Glauce Socorro de Barros Viana,
... action of lithium (Li) alone or with pilocarpine (Pilo), focusing on muscarinic and dopaminergic systems and also ... for 7 days (7 d), 24 h before Pilo (15 mg\kg), exacerbated cholinergic signs, leading to ... the hippocampus after atropine (Atro) and Li-Atro-Pilo treatments, respectively, as compared to controls (Atro) and the Li-Pilo group (Li-Atro-Pilo). In the striatum, except for the 37% increase in the Li-Atro (50 mg\kg)-Pilo group as compared to the Li-Pilo one, no other changes were observed in MR. ... observed and this effect was blocked by Li-Pilo. As far as inositol phosphates (IP) and phosphatidylinositol- ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
1998 - Elsevier BV | Neurochemistry International
Ran Xiao, Jing Xiang, Panpan Song, Li Jiang, Benke Liu, Yue Hu,
... rats were used to establish a lithium-pilocarpine (pilo) epileptic model, and were assigned to a lithium-pilocarpine (PILO), VPA + PILO, QUIN + PILO or CBX + PILO group. Intracranial electroencephalography was performed before and after ... lower in the intervention groups than in the PILO group (p < 0.05). Seizures induced CX43 expression, ... the FRs was significantly lower in the VPA + PILO and QUIN + PILO groups than in the PILO group at 10 min after SE, 10 min ... power of FRs was lower in the CBX + PILO group than in the PILO group at 10 ...
Tópico(s): Ion channel regulation and function
2018 - Elsevier BV | Epilepsy Research
Produção Nacional
Revisado por pares
Aline Priscila Pansani, Roberta Monterazzo Cysneiros, Diego Basile Colugnati, Luciana Janjoppi, Danuza Ferrari, Eliângela de Lima, Poliana Peres Ghazale, Rita Sinigaglia‐Coimbra, Fúlvio A. Scorza,
... into two main groups: control (Ctr) and pilocarpine (Pilo). Each one was subdivided according to treatment: vehicle (Ctr V and Pilo V) or vitamin E at dosages of 6 IU/kg/day (Ctr E6 and Pilo E6) or 60 IU/kg/day (Ctr E60 and Pilo E60). Treatment lasted 120 days from status epilepticus ( ... were grouped. Carbonyl content in the hippocampus of Pilo V and Pilo E6 was higher compared with that of the ... 0.3 nmol carbonyl/mg protein, respectively for Pilo V, Pilo E6, and Ctr; p < 0.05). Carbonyl content was restored to control values in Pilo E60 rats (4.2 ± 1.1 and 3. ...
Tópico(s): Epilepsy research and treatment
2018 - Elsevier BV | Epilepsy & Behavior
Francis W. Price, Milton M. Hom, Majid Moshirfar, David G. Evans, Haixia Liu, Jeff Penzner, Michael R. Robinson, Sung Wook Lee, David Wirta,
... safety, efficacy, and tolerability of combinations of pilocarpine (Pilo) and oxymetazoline (Oxy) ocular drops dosed once daily ... both studies with various concentrations and combinations of Pilo (0%, 0.5% 1.0%, and 1.5%) ... baseline in UNVA.ResultsIn the short-term study, Pilo was shown to produce a significant dose response ... incidence or severity of headaches when compared with Pilo alone. Efficacy results from the extended study supported ... and determined that the optimal concentration range of Pilo is between 1.16% and 1.32%.ConclusionsOn ...
Tópico(s): Ophthalmology and Eye Disorders
2021 - Elsevier BV | Ophthalmology Science
Produção Nacional
Revisado por pares
Margareth Rose Priel, Edson X. Albuquerque,
... an epileptogenic factor in humans. In the pilocarpine (PILO) model, after a brief period marked by SE, ... study was to identify the molecular actions of PILO that could account for its ability to induce ... in the absence and in the presence of PILO (1–10 μ M ), to study the spontaneous ... currents. The postsynaptic currents were isolated pharmacologically. Results: PILO (1 and 10 μ M ) caused an initial ... that this effect is mediated through muscarinic receptors. PILO also promoted a brief increase of the amplitude ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2002 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Beatriz M. Longo, Annamaria Vezzani, Luiz E. Mello,
... rats subject to status epilepticus induced by pilocarpine (Pilo), previously injected or not with cycloheximide (CHX), which ... inhibit MFS. Methods: CHX was injected before the Pilo injection in adult Wistar rats. The Pilo group was injected with the same drugs, except ... difference regarding GAP43‐ir in the IML between Pilo, CHX+Pilo, and control groups. However, the results of the ... ir band in the IML showed that CHX+Pilo and control animals had a significantly larger band ( ... 0.03) as compared with that in the Pilo group. Conclusions: Our current finding that animals in ...
Tópico(s): Neuroscience and Neuropharmacology Research
2005 - Wiley | Epilepsia
Véronique André, Arielle Ferrandon, Christian Marescaux, Astrid Nehlig,
... The rats treated with ECS before pilocarpine (ECS-pilo) developed partial limbic (score 2) and propagated seizures ( ... than the rats that underwent SE alone (sham-pilo). Despite this delay in the initiation and propagation ... seizures, the same number of ECS- and sham-pilo rats developed SE with a similar characteristic pattern. ... in the amygdala and the cortex. In ECS-pilo rats, c-Fos expression was decreased in the ... reticulata, entorhinal and perirhinal cortices compared to sham-pilo rats. Finally, while 11 out of the 12 ...
Tópico(s): Nerve injury and regeneration
2000 - Elsevier BV | Epilepsy Research
Produção Nacional
Revisado por pares
Alexandre Ademar Hoeller, Marcelo Duzzioni, Filipe Silveira Duarte, Leandro Rinaldi Leme, Ana Paula Costa, Evelyn Cristina da Silva Santos, Claudini Honório de Pieri, Alessandra Antunes dos Santos, Aline Aita Naime, Marcelo Farina, Thereza Christina Monteiro de Lima,
... convulsant doses of the muscarinic receptor agonist pilocarpine (PILO) induces long-lasting anxiogenic responses in rats evaluated ... To investigate the underlying mechanisms, rats treated with PILO (150 mg/kg) were injected 24 h or ... and acetylcolinesterase (AChE) activity were also analyzed after PILO treatment. Anxiogenic responses observed in the EPM 24 h or 1 month after PILO treatment (e.g., decreased time spent and number ... PFC at 24 h or 1 month after PILO injection, but enhanced theta activity was observed in ...
Tópico(s): Receptor Mechanisms and Signaling
2013 - Elsevier BV | Brain Research
Véronique M. André, Marie‐Aude Rigoulot, Estelle Koning, Arielle Ferrandon, Astrid Nehlig,
... after pilocarpine, rats received 50 mg/kg PGB (pilo-preg) or saline (pilo-saline). PGB treatment was given daily at the ... was limited to the hilus and similar in pilo-preg and pilo-saline animals. The number of GFAP-positive astrocytes ... in saline-treated rats. It was decreased in pilo-preg compared with pilo-saline rats in layer II of the piriform cortex. Adult pilo-preg rats became epileptic after a longer latency (39 days) than did pilo-saline rats (22 days).These data underline the ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2003 - Wiley | Epilepsia
Mohammed Qutyan, Michael J. Paliotti, Peter Castric,
Summary PilO of Pseudomonas aeruginosa 1244 catalyses the attachment of an O‐antigen repeating unit to the β‐carbon ... cellular location of the pilin glycosylation reaction. While PilO was not detectable in extracts of P. aeruginosa ... overexpression, it was found that an intact MalE–PilO fusion protein was produced in significant amounts. This ... complemented a P. aeruginosa 1244 mutant containing a pilO deletion and targeted to the cytoplasmic membrane of ... were found to share a sequence pattern with PilO even though these proteins have little overall sequence ...
Tópico(s): Bacterial Genetics and Biotechnology
2007 - Wiley | Molecular Microbiology
Hadeel Zakaria Alsaegh, Hala Salah Abdel Kawy, Fatemah O. Kamel, Aziza Alrafiah,
... susceptibility and organ damage in lipopolysaccharides (LPS)/pilocarpine (PILO) pretreated Wistar rats. Rats were divided into 6 groups (8 each): group 1 (control), group 2 (PILO), group 3 (PILO+LPS), group 4 (PILO+LPS+(VPA) Valproic acid), group 5 (PILO+LPS+Celecoxib), and group 6 (PILO+LPS+VPA+Celecoxib). LPS was used to induce sepsis and PILO to induce seizures. Oxidative stress markers, pro-inflammatory ... on acute seizures and inflammatory models induced by PILO with LPS. It decreased histopathological findings, oxidative, and ...
Tópico(s): Inflammatory mediators and NSAID effects
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Margaret Williams, W.J. Cunliffe, David Gould,
... of DermatologyVolume 90, Issue 6 p. 631-635 Pilo-sebaceous duct physiology. I EFFECT OF HYDRATION ON PILO-SEBACEOUS DUCT ORIFICE M. WILLIAMS, M. WILLIAMS The ... Using a surface microscope technique to measure the pilo-sebaceous duct orifices in vivo, it has been ... hot bath or by polythene occlusion, decreases the pilo-sebaceous orifice size. These changes arc reversed within 90 min. This reduction in pilo-sebaceous duct orifice size would increase sebum outflow ...
Tópico(s): Acne and Rosacea Treatments and Effects
1974 - Oxford University Press | British Journal of Dermatology
... products of the remaining essential genes, pilK, pilM, pilO, pilP, pilR, and pilT, with regard to their localization and processing. Overexpression systems containing pilM, pilO, and pilP genes fused with N-terminal glutathione ... used to raise specific antibodies. Localization of PilM, PilO, and PilP proteins was performed by Western blot analysis with anti-GST-PilM, anti-PilO, and anti-PilP antibodies, respectively. The pilK, pilR, ... proteins, and PilP and PilT are periplasmic proteins. PilO protein was localized to the outer membrane in ...
Tópico(s): Bacteriophages and microbial interactions
2002 - American Society for Microbiology | Journal of Bacteriology
Manuel J. Castillo, André Scheen, Michel Letiexhe, Pierre J. Lefèbvre,
... CASPubMedWeb of Science®Google Scholar 17 Navalesi R, Pilo A, and Ferrannini E: Kinetic analysis of plasma ... 2-279 CASPubMedWeb of Science®Google Scholar 22 Pilo A, Ferrannini E, and Navalesi R: Measurement of ... of Science®Google Scholar 86 Ferrannini E, and Pilo A: Pattern of insulin delivery after intravenous glucose ... 3.368 CASPubMedWeb of Science®Google Scholar 98 Pilo A, Navalesi R, and Ferrannini E: Insulin kinetics ... CASPubMedWeb of Science®Google Scholar 99 Navalesi R, Pilo A, Lenzi S, and Donato L: Insulin metabolism ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
1994 - Wiley | Diabetes/Metabolism Reviews
Produção Nacional
Revisado por pares
Cláudia P. Figueiredo, Victor L. S. Antunes, Eduardo Luiz Gasnhar Moreira, Nelson de Mello, Rodrigo Medeiros, Gabriella Di Giunta, Bruno Lobão‐Soares, Marcelo Neves Linhares, Kátia Lin, Tânia Longo Mazzuco, Rui Daniel Prediger, Roger Walz,
... Cx) of rats undergoing pilocarpine induced status epilepticus (Pilo-SE), and in three young male patients with ... the GIPR expression and neuronal degeneration induced by Pilo-SE. GIPR was expressed in the cytoplasm of ... and human samples. The GIPR expression after the Pilo-SE induction increases significantly in the HIP after ... 5 days, but not 50 days after the Pilo-SE. The expression of GIPR 12 h after Pilo-SE was inversely proportional to the Fluoro-Jade ... patterns were similar to those observed in chronic Pilo-SE animals. No Fluoro-Jade stained cells were ...
Tópico(s): Epilepsy research and treatment
2010 - Elsevier BV | Peptides
Mohammed Qutyan, Matthew Henkel, Joseph Horzempa, Michael Quinn, Peter Castric,
PilO is an oligosaccharyl transferase (OTase) that catalyzes the O-glycosylation of Pseudomonas aeruginosa 1244 pilin by ... of the C-terminal residue (a serine). While PilO has an absolute requirement for Ser/Thr at ... region of strain 1244 pilin, served as a PilO substrate when it was expressed on either group ... C terminus of a group III pilin supported PilO activity. A protein fusion composed of strain 1244 ... acids at its C terminus) was glycosylated by PilO. E. coli alkaline phosphatase lacking the pilin membrane ...
Tópico(s): Bacterial Genetics and Biotechnology
2010 - American Society for Microbiology | Journal of Bacteriology
Produção Nacional
Revisado por pares
Cleiton Lopes‐Aguiar, Lézio Soares Bueno-Júnior, Rafael Naime Ruggiero, Rodrigo Neves Romcy-Pereira, João Pereira Leite,
... order to test the potentiating effects of pilocarpine (PILO), independent groups of rats received either a microinjection of PILO (40 nmol; i.c.v.) or vehicle, immediately ... intra-mPFC) or vehicle, 10 min prior to PILO preceding LFS600, or prior to a supra-threshold ... pulses, 1 Hz; LFS900). Our results show that PILO converts a transient cortical depression induced by LFS600 ... at least 4 h. When applied after LFS600, PILO does not change either mPFC basal neurotransmission or ... transient depression into long-lasting LTD produced by PILO. In addition, AP7 effectively blocked the long-lasting ...
Tópico(s): Memory and Neural Mechanisms
2012 - Elsevier BV | Neuropharmacology
Takahiro Imamura, Yoko Yoshino, Shigeo Yamachika, Hisako Ishii, Nobuyuki Watanabe, Hiroko Inoue, Yoichi Nakagawa,
... secretion stimulated by the muscarinic receptor agonist pilocarpine (PILO) in mice. Mice were injected with either 0.5 mg/kg, i.p. PILO alone or simultaneously with 2 mg/kg, i. ... c.), which was administered 30 min prior to PILO and/or IPR. Saliva volume decreased significantly in the mice treated simultaneously with PILO + IPR compared with that in mice treated with PILO alone. Changes in the intracellular localization of AQP5 were seen in PILO + IPR-treated mice, and those changes were reversed ... addition, the decreased salivary flow rate in the PILO + IPR-treated mice was partially restored by SQ22536 ...
Tópico(s): Salivary Gland Disorders and Functions
2012 - Wiley | Clinical and Experimental Pharmacology and Physiology
Bruce E. McKay, Michael A. Persinger,
... attenuating cognitive impairments in the lithium–pilocarpine (LI–PILO) model of rat limbic epilepsy. Declarative-like cognitive ... platform) training. Whereas the ketamine-treated (Ket) LI–PILO rats performed equally in all respects to nonseized ... water maze task, the acepromazine-treated (Ace) LI–PILO rats failed to demonstrate learning in either the ... with a standard contextual fear-conditioning protocol. LI–PILO rats treated with acepromazine failed to learn the Pavlovian relationship; Ket LI–PILO rats performed equivalently to nonseized controls. Cumulatively, these ...
Tópico(s): Epilepsy research and treatment
2004 - Elsevier BV | Pharmacology Biochemistry and Behavior