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Artigo Revisado por pares

Éric Ravussin, Mauro E. Valencia, Julián Esparza‐Romero, Peter H. Bennett, Leslie O. Schulz,

... abrupt changes in lifestyle, these prevalences in Arizona Pimas have increased to epidemic proportions during the past ... compared with sex-, age- and diabetes status-matched Pimas living in Arizona (10 Arizona Pimas for each Mexican Pima). RESULTS Mexican Pimas were lighter (64.2 ± 13.9 vs. 90. ... mg/dl, P < 0.0001) than Arizona Pimas. Only two women (11%) and one man (6%) ... 37 and 54% in female and male Arizona Pimas, respectively. CONCLUSIONS This preliminary investigation shows that obesity, ... Pima heritage living a “traditional” lifestyle than among Pimas living in an “affluent” environment. These findings suggest ...

Tópico(s): Diet and metabolism studies

1994 - American Diabetes Association | Diabetes Care

Primary Document Acesso aberto

Parke, John G., Emory, William H. (William Hemsley),

"Route near the thirty-second parallel. Extract from Report of Lieutenant Colonel Emory, of a military reconnaissance made in 1846 and 1847"--p. 33-53. ...

0000 - Gale Group | Sabin

Artigo Revisado por pares

M. Nagulesparan, Peter J. Savage, William C. Knowler, Ginger C. Johnson, Peter H. Bennett,

... development of fasting hyperglycemia, insulin concentrations in the Pimas are elevated both during fasting and after a ... measure of insulin resistance. SSPG concentrations in both Pimas and Caucasians correlated significantly with obesity and with ... concentrations. SSPG levels were significantly higher in the Pimas (P < 0.01) and remained so even ... sex (35 ± 1 2 mg/dl higher in Pimas than in Caucasians, P < 0.01), indicating that hyperinsulinemia in the Pimas reflects a resistance to insulin action and that ...

Tópico(s): Diabetes Treatment and Management

1982 - American Diabetes Association | Diabetes

Documentos governamentais Acesso aberto

... of the native people in the province of Pimas Altos, Sonora. Includes an extensive report on the ...

1737 - Gale Group | World Scholar Latin America

Artigo Revisado por pares

Stephen Aronoff, S L Schnider, JAMES S. SMELTZER, Wilma Mackay, Pat Tchou, Norman B. Rushforth, Max Miller, Peter H. Bennett,

... total protein excretion demonstrated similar levels in nondiabetic Pimas [8.6 mg/24 h (median), 5.0- ... 7-29.0 mg/24 h] and nondiabetic Pimas had similar values. Mean blood pressure and fasting ... correlated with total protein excretion in the diabetic Pimas. Measurable quantities of only 9 of the 17 ... and clearances ofthese proteins were comparable in nondiabetic Pimas and Caucasians. Compared with nondiabetic Pimas, diabetics had significantly higher clearance and excretion of ... these proteins, a significantly higher percentage of diabetic Pimas had detectable excretion of these proteins except for ...

Tópico(s): Diabetes and associated disorders

1981 - American Diabetes Association | Diabetes

Documentos governamentais Acesso aberto

... of the native people in the province of Pimas Altos, Sonora. Includes an extensive report on the ...

1737 - Gale Group | World Scholar Latin America

Artigo Acesso aberto Revisado por pares

Barbara V. Howard, Mike Davis, David J. Pettitt, W C Knowler, Peter H. Bennett,

... correlation between obesity and HDL cholesterol levels in Pimas. Obesity appeared to account for the lower HDL ... between the sexes in HDL levels in the Pimas. Triglyceride levels correlated positively with obesity in the Pimas, but the relationship was not as strong as ... that there are differences in lipoprotein distributions between Pimas and U.S. Caucasians; the relationship between lipoprotein ... and the incidence of coronary disease in the Pimas must be determined.

Tópico(s): Nutritional Studies and Diet

1983 - Lippincott Williams & Wilkins | Circulation

Artigo Acesso aberto Revisado por pares

Richard E. Pratley, Leslie J. Baier, David Pan, Arline D. Salbe, L. H. Storlien, Éric Ravussin, Clifton Bogardus,

... of diabetes and its metabolic precursors in the Pimas suggested a linkage between insulin action, determined during ... apparent effects on triglyceride metabolism in vivo in Pimas. Fasting plasma triglyceride concentrations were similar in both ... ethnic variation. It is known, for example, that Pimas tend to have low plasma triglyceride concentrations relative ... J. Clin. Invest. 1995; 95: 1281-1287Google Scholar), Pimas with the Thr54 FABP2 allele tended to have ... with a nearby unidentified disease gene in the Pimas. This linkage may or may not be present ...

Tópico(s): Alcohol Consumption and Health Effects

2000 - Elsevier BV | Journal of Lipid Research

Artigo Revisado por pares

Johanna K. Wolford, Robert L. Hanson, Sayuko Kobes, Clifton Bogardus, Michal Procházka,

... alterations within KCNJ9 to diabetes susceptibility in the Pimas, we have genotyped 11 single nucleotide polymorphisms (SNPs) in 50 Pimas with diabetes and 50 Pimas over the age of 45 without diabetes and ... found in the original linkage set comprising 1150 Pimas (odds ratio = 0.64/P = 0.079 for ... variants in KCNJ9 are associated with diabetes in Pimas but do not account for the linkage of ...

Tópico(s): Ion channel regulation and function

2001 - Elsevier BV | Molecular Genetics and Metabolism

Artigo Acesso aberto Revisado por pares

Wen‐Chi Hsueh, Peter H. Bennett, Julián Esparza‐Romero, René Urquídez-Romero, Mauro E. Valencia, Éric Ravussin, Robert C. Williams, William C. Knowler, Leslie J. Baier, Leslie O. Schulz, Robert L. Hanson,

... GWAS) and 96 random markers, in 342 Mexican Pimas. A multimarker risk score of obesity variants was ... value of the score was lower in Mexican Pimas than in US Pimas (P = 4.3 × 10-11 ), and differences in ... 283 variants were compared between US and Mexican Pimas, accounting for genetic distance. The largest differences were ... 46 ). Analyses of GWAS data in 937 US Pimas also showed sharing of alleles identical by descent ...

Tópico(s): Cancer-related molecular mechanisms research

2018 - Wiley | Annals of Human Genetics

Artigo Revisado por pares

Stephen Aronoff, Peter H. Bennett, Phillip Görden, Norman B. Rushforth, Max Miller,

... diabetes in the Pima Indians, 26 genetically normal Pimas (nondiabetic offspring of nondiabetic parents), 32 genetically prediabetic Pimas (nondiabetic offspring of diabetic parents), 10 diabetic Pimas, and 29 normal Caucasians were studied. All subjects ... was a rapid response in all nondiabetics. Prediabetic Pimas with normal or abnormal CGTT had insulin levels ...

Tópico(s): Diabetes Management and Research

1977 - American Diabetes Association | Diabetes

Artigo Revisado por pares

Stephen Aronoff, Peter H. Bennett, Norman B. Rushforth, Max Miller, Roger H. Unger,

... similar glucagon response to arginine and (2) diabetic Pimas had excessive glucagon response to arginine as reported ... mg./kg./minute for 40 minutes) the diabetic Pimas had glucagon levels significantly higher at 10 minutes ... all sampling points thereafter than the normo-glycemic Pimas. Plasma insulin levels also increased during the infusion ... levels at any sampling point between the nondiabetic Pimas and Caucasians. The differences in glucagon levels between ...

Tópico(s): Diabetes Management and Research

1976 - American Diabetes Association | Diabetes

Artigo Revisado por pares

Mohammad F. Saad, Sharon Alger, F. Zurlo, J. B. Young, Clifton Bogardus, Éric Ravussin,

... 95 +/- 41 kg, 22 +/- 13% fat] and 33 Pimas (29 +/- 6 yr, 103 +/- 28 kg, 30 +/- 9% ... P less than 0.001) but not in Pimas (r = 0.03), independent of fat-free mass ( ... 103 +/- 36 kg, 25 +/- 11% fat) and 32 Pimas (28 +/- 6 yr, 100 +/- 34 kg, 27 +/- 10% ... P less than 0.001) but not in Pimas (-0.8%, P = 0.07).(ABSTRACT TRUNCATED AT ...

Tópico(s): Regulation of Appetite and Obesity

1991 - American Physiological Society | AJP Endocrinology and Metabolism

Artigo Revisado por pares

Boyd Swinburn, VL Boyce, Richard N. Bergman, B. V. Howard, Clifton Bogardus,

... over the last century. In this study, 12 Pimas and 12 Caucasians, all nondiabetic, were admitted to ... P < 0.02), and similar β-cell capacities. Pimas and Caucasians responded similarly, except for larger changes in plasma lipids among the Pimas. Since glucose-mediated glucose disposal, β-cell function, ... the prevalence of noninsulindependent diabetes mellitus in both Pimas and Caucasians.

Tópico(s): Muscle metabolism and nutrition

1991 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism

Artigo Revisado por pares

Maurice L. Sievers, Robert G. Nelson, Peter H. Bennett,

... DESIGN AND METHODS Underlying causes of death in Pimas aged 15 years old were determined for the ... 95% CI 0.70–1.4) or nondiabetic Pimas (DRR = 0.92, 95% CI 0.74–1.1). Among diabetic Pimas, however, the death rate for diabetic nephropathy declined ... 0.91–2.6). For diabetic and nondiabetic Pimas combined, the death rate in three consecutive 5- ...

Tópico(s): Chronic Disease Management Strategies

1996 - American Diabetes Association | Diabetes Care

Artigo Acesso aberto Revisado por pares

Julián Esparza‐Romero, Mauro E. Valencia, René Urquídez-Romero, Lisa S. Chaudhari, Robert L. Hanson, William C. Knowler, Éric Ravussin, Peter H. Bennett, Leslie O. Schulz,

... glucose, impaired glucose tolerance, and obesity in Mexican Pimas (n = 359) and non-Pima Mexicans (n = 251) ... in Pima men. Prevalence of obesity increased among Pimas and non-Pimas of both sexes. These changes occurred concomitantly with ...

Tópico(s): Global Public Health Policies and Epidemiology

2015 - American Diabetes Association | Diabetes Care

Artigo Acesso aberto Revisado por pares

Wen-Chi Hsueh, Anup K. Nair, Sayuko Kobes, Peng Chen, Harald H.H. Göring, Toni I. Pollin, Alka Malhotra, William C. Knowler, Leslie J. Baier, Robert L. Hanson,

... unit; P=9.6×10-55 in 4668 Pimas and 2793 Southwest Amerindians combined). The Thr allele ... but has a frequency of 2.5% in Pimas. We further demonstrated that 3 APOA5 SNPs with ... for 6.9% of variation in triglycerides in Pimas (and 4.1% in Southwest Amerindians), and their ... locus for serum triglycerides in Amerindians, especially the Pimas, and these results provide an empirical example for ...

Tópico(s): RNA modifications and cancer

2017 - Lippincott Williams & Wilkins | Circulation Cardiovascular Genetics

Artigo Revisado por pares

Jayagopal Madhavaraju, Yong Il Lee, Robert W. Scott, Carlos M. González–León, Hugh C. Jenkyns, Julio Cesar Saucedo‐Samaniego, S. Ramasamy,

... Mural Formation that is exposed in the Cerro Pimas area of northern Sonora, Mexico, is composed of ... limestones. The carbon-isotopic curve of the Cerro Pimas stratigraphic section has well-defined δ13C segments (C8 – ... Leenhardt Events (OAE 1b cluster) in the Cerro Pimas stratigraphy confirms the global nature of these early ...

Tópico(s): Geochemistry and Elemental Analysis

2017 - Elsevier BV | Journal of South American Earth Sciences

Artigo Revisado por pares

Peter J. Savage, Richard F. Hamman, Gregory W. Bartha, Stephen E. Dippe, Max Miller, Peter H. Bennett,

... 2.6 mg/100 ml) were similar in Pimas and Caucasians, but levels in Pimas from 5 to 16 years (148 +/- 4.6 ... ages 17 to 25. Cholesterol levels in adult Pimas (190 +/- 1.5 mg/100 ml) were up ...

Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins

1976 - American Academy of Pediatrics | PEDIATRICS

Artigo Revisado por pares

Lynn J. Bennion, William C. Knowler, David M. Mott, Alan M. Spagnola, Peter H. Bennett,

... of the rapid postpubertal increase in gallstones in Pimas, we studied the bile of 66 Pimas nine to 21 years of age. Highly saturated bile is not prevalent among Pimas under the age of 13, but bile saturation ...

Tópico(s): Pediatric Hepatobiliary Diseases and Treatments

1979 - Massachusetts Medical Society | New England Journal of Medicine

Artigo Acesso aberto Revisado por pares

B. V. Howard, Genshi Egusa, W F Beltz, Y. Antero Kesäniemi, S M Grundy,

... apoB was similar (1224 * 87 mg/d in Pimas vs 1218 * 118 mgld in Caucasians) but in Pimas the fractionalcatabolic rate (FCR) for LDL-apoB was ... 0.04 d-', P < 0.05).In the Pimas, a much higher proportion of VLDL-apoB was ...

Tópico(s): Cancer, Lipids, and Metabolism

1986 - Elsevier BV | Journal of Lipid Research

Artigo Acesso aberto Revisado por pares

Barbora Vozarova, Christian Weyer, Søren Snitker, Jean‐François Gautier, Giovanni Cizza, George P. Chrousos, Éric Ravussin, P. Antonio Tataranni,

... system activity (MSNA), microneurography] in 58 males [27 Pimas/31 Caucasians]. Seven Pimas and 12 Caucasians were randomized to a double- ... adjusted for percent body fat was lower in Pimas than in Caucasians (P < 0.006). No correlation ...

Tópico(s): Adrenal Hormones and Disorders

2003 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism

Artigo Revisado por pares

William C. Knowler, Mohammed Saad, David J. Pettitt, Robert G. Nelson, Peter H. Bennett,

... for classification of glucose tolerance. Diabetes in the Pimas is strongly familial, and probably of genetic origin, ... in diabetes. The incidence of diabetes in the Pimas has increased during the last several decades, providing ... leads to worsening hyperglycemia and overt diabetes.The Pimas and many other American Indian populations suffer from ...

Tópico(s): Diabetes and associated disorders

1993 - American Diabetes Association | Diabetes Care

Artigo Revisado por pares

Stephen Lillioja,

... intact in individuals with IGT. We also compared Pimas and Caucasians with NGT or IGT. Subjects were ... clamp. The results showed that insulin concentrations in Pimas with IGT were not lower than the levels ... failure, is the principal lesion determining IGT in Pimas. NIDDM occurs when beta-cell failure develops in ...

Tópico(s): Genetic Associations and Epidemiology

1996 - Wiley | Diabetic Medicine

Artigo Acesso aberto Revisado por pares

Johanna K. Wolford, Clifton Bogardus, Victoria Ossowski, Michal Procházka,

... within this locus to disease susceptibility in the Pimas, we have investigated its genomic sequences. The PEA15 ... transcription factor binding sites. By analysis of 22 Pimas, including 13 diabetic subjects, we detected four single ... diabetes mellitus in 50 affected and 50 control Pimas (p=0.12-0.17), and we conclude ...

Tópico(s): Protein Kinase Regulation and GTPase Signaling

2000 - Elsevier BV | Gene

Artigo Acesso aberto Revisado por pares

Jayagopal Madhavaraju, Yong Il Lee, Carlos M. González–León,

... the shallow marine Mural Formation in the Cerro Pimas locality of northern Sonora (Mexico) was undertaken to ... of the episode OAE 1b in the Cerro Pimas section. The 87Sr/86Sr ratios for limestones of ...

Tópico(s): Geological and Geochemical Analysis

2013 - Springer International Publishing | Journal of Iberian Geology

Artigo Acesso aberto Revisado por pares

David Milewski, David Balli, Vladimir Ustiyan, Tien Le, Hendrik Dienemann, Arne Warth, Kai Breuhahn, Jeffrey A. Whitsett, Vladimir V. Kalinichenko, Tanya V. Kalin,

... transcription factor (FOXM1) is highly expressed in human PIMAs and associated with increased extracellular mucin deposition and ... of mucins, was increased in mouse and human PIMAs and was associated with FOXM1. FOXM1 directly bound ... inhibition of either FOXM1 or AGR2 in human PIMAs inhibited mucinous characteristics, and reduced tumor growth and ...

Tópico(s): Circular RNAs in diseases

2017 - Public Library of Science | PLoS Genetics

Artigo Revisado por pares

Donald E. Chipman, John L. Kessell,

... Article Mission of Sorrows: Jesuit Guevavi and the Pimas, 1691–1767. By John L. Kessell. (Tucson: University ...

Tópico(s): Latin American history and culture

1970 - Oxford University Press | Journal of American History