Shari A. Weech, Anton M. Scheuhammer, John E. Elliott,
... whether Hg from geologic/mining-related sources at Pinchi Lake (BC, Canada) was causing elevated Hg exposure ... eating birds, breeding bald eagles (Haliaeetus leucocephalus) on Pinchi Lake and four nearby reference lakes were sampled ... levels in species at various trophic levels from Pinchi Lake averaged approximately twice those in the same ... absence of substantial new inputs of Hg to Pinchi Lake over several decades. In Pinchi Lake, Hg concentrations in blood and feathers of ... microg/g wet wt) in grebe eggs from Pinchi Lake was substantially lower than accepted threshold levels ...
Tópico(s): Heavy Metal Exposure and Toxicity
2006 - Wiley | Environmental Toxicology and Chemistry
A Plouffe, Pat E. Rasmussen, G.E.M. Hall, P Pelchat,
... producing Hg mines located in British Columbia, Canada: Pinchi Lake and Bralorne Takla mines. Sequential extraction analyses ... geogenic source. Mercury in the B horizon at Pinchi Lake mine could be derived in part from ... horizon. Mercury and Sb concentrations in humus near Pinchi Lake mine (<10 km) appear to be derived ... of natural concentrations in the C horizon. Near Pinchi Lake mine, biogeochemical cycling and gaseous Hg derived ... compared to the C horizon only observed near Pinchi Lake mine would also be present at several ...
Tópico(s): Geochemistry and Elemental Analysis
2004 - Zoological Society of London | Geochemistry Exploration Environment Analysis
Shari A. Weech, Anton M. Scheuhammer, John E. Elliott, Kimberly M. Cheng,
... and northern pikeminnow (Ptychocheilus oregonensis) were collected from Pinchi Lake, British Columbia, and from several nearby reference lakes. Hg concentrations in sediment samples from Pinchi L. were highly elevated compared to sediments from ... concentrations in both fish species were highest in Pinchi L., and were higher in pikeminnow than in ... in small rainbow trout from all lakes, including Pinchi L., were lower than dietary levels reported to ... immer); however, Hg levels in small pikeminnow from Pinchi L. were sufficiently high to be of concern. ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2004 - Elsevier BV | Environmental Pollution
At Pinchi Lake, the Pinchi Fault Zone separates the early Mesozoic Takla Group to the east from the late Paleozoic Cache Creek Group to the ... which involves right lateral transform faulting on the Pinchi Fault and underthrusting along northerly dipping subduction zones ...
Tópico(s): Seismic Waves and Analysis
1977 - NRC Research Press | Canadian Journal of Earth Sciences
Edward D. Ghent, Philippe Erdmer, Douglas A. Archibald, Mavis Z. Stout,
... largest faults in the Canadian Cordilleran Orogen, the Pinchi fault. Blueschists (in situ) and retrogressed eclogite blocks occur along the Pinchi fault zone near 54°30'N and 124° ... Eocene time as a strike-slip zone. The Pinchi blueschist terrane is similar to others in the ...
Tópico(s): High-pressure geophysics and materials
1996 - NRC Research Press | Canadian Journal of Earth Sciences
Brian E. Patrick, Howard W. Day,
... 1993. Pressure-temperature evolution of lawsonite-bearing eclogites, Pinchi Lake, British Columbia. Journal of Metamorphic Geology, 11, ... A., 1977. The geology and evolution of the Pinchi Fault Zone at Pinchi Lake, central British Columbia. Canadian Journal of Earth ... E., 1974. Potassium-argon dating of blueschists from Pinchi Lake, central British Columbia. Canadian Journal of Earth ...
Tópico(s): earthquake and tectonic studies
1995 - Wiley | Journal of Metamorphic Geology
Edward D. Ghent, Douglas K. Tinkham, Robert A. Marr,
Lawsonite eclogites from Pinchi Lake, British Columbia, occur as tectonic blocks associated with lawsonite, aragonite, and jadeite-bearing blueschists. One tectonic block from ... and the calculated stability fields of lawsonite for Pinchi Lake samples. This is very near the P– ...
Tópico(s): Clay minerals and soil interactions
2008 - Elsevier BV | Lithos
Marc Tardy, Henriette Lapierre, Lambertus C. Struik, Delphine Bosch, Pierre Brunet,
... clinopyroxene-rich ultramafic rocks are exposed within the Pinchi Fault system. The mid-Permian lavas show affinities ... earth element enrichment. The mafic rocks within the Pinchi Fault system are similar to N-type mid- ... Triassic type 1 and igneous rocks from the Pinchi Fault system have the highest ε Nd(i) ...
Tópico(s): earthquake and tectonic studies
2001 - NRC Research Press | Canadian Journal of Earth Sciences
E. D. Ghent, Mavis Z. Stout, P Erdmer,
... Blueschists and retrogressed eclogites are located along the Pinchi Fault Zone (near 54°30′N and 124°W) in central British Columbia. The Pinchi Fault separates rocks of contrasting geological histories, and ...
Tópico(s): High-pressure geophysics and materials
1993 - Wiley | Journal of Metamorphic Geology
... and northern pikeminnow (Ptychocheilus oregonensis) were collected from Pinchi Lake, British Columbia, and from several nearby reference lakes. Hg concentrations in sediment samples from Pinchi L. were highly elevated compared to sediments from ... concentrations in both fish species were highest in Pinchi L., and were higher in pikeminnow than in ... in small rainbow trout from all lakes, including Pinchi L., were lower than dietary levels reported to ... immer); however, Hg levels in small pikeminnow from Pinchi L. were sufficiently high to be of concern. ...
Tópico(s): Mercury impact and mitigation studies
2004 - Elsevier BV | Environmental Pollution
Shannon M. Crowley, Dexter P. Hodder, Chris J. Johnson, David E. Yates,
... inactive and reclamated mercury mine along its shoreline (Pinchi Lake). We used a combination of remote cameras, ... found that mercury concentrations in river otter inhabiting Pinchi Lake were significantly higher than all other lakes ...
Tópico(s): Wildlife Ecology and Conservation
2018 - Elsevier BV | Ecological Indicators
E. Irving, Derek J. Thorkelson, P. M. Wheadon, R. J. Enkin,
... strike‐slip faults (Northern Rocky Mountain Trench, Finlay, Pinchi etc.). In the south, our results require a ... This could be a southern extension of the Pinchi Fault whose trace is now obscured by Eocene ...
Tópico(s): Geological formations and processes
1995 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Mordeckai Magaritz, Hugh P. Taylor,
... the eastern edge of the batholith to the Pinchi fault zone. Only in Zone I are isotopically ' ... meteoric-hydrothermal effects are not found east of Pinchi Lake, a terrane that includes the Permian Cache ...
Tópico(s): Isotope Analysis in Ecology
1976 - NRC Research Press | Canadian Journal of Earth Sciences
I. A. Paterson, J. E. Harakal,
Geologic and radiometric evidence demonstrates that the Pinchi Lake blueschists underwent an early deformation, blueschist metamorphism, uplift, cooling, and a second deformation during the Triassic Tahltanian orogeny. Potassium–argon dates on ...
Tópico(s): Geology and Paleoclimatology Research
1974 - NRC Research Press | Canadian Journal of Earth Sciences
Norvald Fimreite, William Norton Holsworth, J. A. Keith, Philippa Pearce, Charles G Gruchy,
... Clair), pumpkinseed (St.Clair River), and lake trout (Pinchi Lake) contained concentrations up to 5.01, 7. ... riviére Sainte-Claire) et truites grises (le lac Pinchi) on a trouvé des concentrations individuelles de mercure ...
Tópico(s): Mercury impact and mitigation studies
1971 - Ottawa Field-Naturalists' Club | The Canadian Field-Naturalist
Near Pinchi Lake, central British Columbia, a fault-bounded alpine peridotite occurs within the Cache Creek Group. It comprises ...
Tópico(s): High-pressure geophysics and materials
1977 - NRC Research Press | Canadian Journal of Earth Sciences
Antonio Oliva, Simone Grassi, Giuseppe Vetrugno, Riccardo Rossi, Gabriele Della Morte, Vilma Pinchi, Pasquale Matteo Caputo,
Artificial intelligence needs big data to develop reliable predictions. Therefore, storing and processing health data is essential for the new diagnostic and decisional technologies but, at the same time, represents a risk for privacy protection. This scoping review is aimed at underlying the medico-legal and ethical implications of the main artificial intelligence applications to healthcare, also focusing on the issues of the COVID-19 era. Starting from a summary of the United States (US) and European ...
Tópico(s): COVID-19 Digital Contact Tracing
2022 - Frontiers Media | Frontiers in Medicine
Antonio Oliva, Simone Grassi, Vincenzo M. Grassi, Vilma Pinchi, Roberto Floris, Guglielmo Manenti, Cesare Colosimo, Laura Filograna, Vincenzo L. Pascali,
Tópico(s): Disaster Response and Management
2021 - Springer Science+Business Media | International Journal of Legal Medicine
Wanlu Du, Mingxue Gu, Meiqin Hu, Prateeksunder Pinchi, W. Chen, Michael P. Ryan, Timothy Nold, Ahmed Bannaga, Haoxing Xu,
Highlights•TRPML1 is dramatically upregulated in metastatic melanoma cells•Activation of TRPML1, instead of inhibition, induces selective melanoma cell death•TRPML-specific synthetic agonists (ML-SAs) trigger a distinctive form of cell death•ML-SAs exhibit potent in vivo therapeutic efficacy in advanced melanoma mouse modelsSummaryDuring tumor progression, lysosome function is often maladaptively upregulated to match the high energy demand required for cancer cell hyper-proliferation and invasion. ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2021 - Cell Press | Cell Reports
Vittorio Fineschi, Anna Aprile, Isabella Aquila, Mauro Arcangeli, Alessio Asmundo, Mauro Bacci, Mariano Cingolani, Luigi Cipolloni, Stefano D’Errico, Ilaria De Casamassimi, Giulio Di Mizio, Marco Di Paolo, Martina Focardi, Paola Frati, Mario Gabbrielli, Raffaele La Russa, Aniello Maiese, Federico Manetti, Massimo Martelloni, Elena Mazzeo, Angelo Montana, Margherita Neri, Martina Padovano, Vilma Pinchi, Cristoforo Pomara, Pietrantonio Ricci, Monica Salerno, Alessandro Santurro, Matteo Scopetti, Roberto Testi, Emanuela Turillazzi, Giuseppe Vacchiano, Filippo Crivelli, Emanuela Bonoldi, Fabio Facchetti, Manuela Nebuloni, Anna Sapino,
The COVID-19 (Coronavirus Disease-19) is the most urgent health emergency worldwide and all professionals are called to give support in the diagnosis and treatment of patients affected by this disease. The Scientific Society of Hospital Legal Medicine of the National Health System (COMLAS) and the Italian Society of Anatomical Pathology and Cytology (SIAPEC) produced this document with the intent of offering a technical support to professional involved in the autoptic activities during the Severe Acute ...
Tópico(s): Body Image and Dysmorphia Studies
2020 - Pacini Editore | Pathologica
Stefan Pittner, Valentina Bugelli, M. Eric Benbow, Bianca Ehrenfellner, Angela Zissler, Carlo Pietro Campobasso, Roelof‐Jan Oostra, Maurice C. G. Aalders, Richard Zehner, L. Lutz, Fabio Monticelli, Christian Staufer, Katharina Helm, Vilma Pinchi, Joseph P. Receveur, Janine Geißenberger, Peter Steinbacher, Jens Amendt,
Estimation of the postmortem interval in advanced postmortem stages is a challenging task. Although there are several approaches available for addressing postmortem changes of a (human) body or its environment (ecologically and/or biochemically), most are restricted to specific timeframes and/or individual and environmental conditions. It is well known, for instance, that buried bodies decompose in a remarkably different manner than on the ground surface. However, data on how established methods for ...
Tópico(s): Forensic Anthropology and Bioarchaeology Studies
2020 - Public Library of Science | PLoS ONE
Marco Clementini, Mario Raspini, Luigi Barbato, Francesco Bernardelli, Giovanni Braga, Claudio Di Gioia, Littarru Cristiano, Oreglia Francesco, Eugenio Brambilla, Ivo Iavicoli, Vilma Pinchi, Luca Landi, Nicola Sforza, Raffaele Cavalcanti, Alessandro Crea, Francesco Cairo,
Current evidence suggests that SARS-CoV-2, the virus that causes COVID-19, is predominantly spread from person to person. Aim of this narrative review is to explore transmission modality of SARS-CoV-2 to provide appropriate advice to stakeholders, in order to support the implementation of effective public health measures and protect healthcare workers that primary face the disease. "In vivo" and "in vitro" studies from laboratories and hospitals confirmed the presence of surface contamination and ...
Tópico(s): COVID-19 and healthcare impacts
2020 - Wiley | Oral Diseases
Margherita Neri, M. Fabbri, Stefano D’Errico, Marco Di Paolo, Paola Frati, Rosa Maria Gaudio, Raffaele La Russa, Aniello Maiese, Matteo Marti, Enrica Pinchi, Emanuela Turillazzi, Vittorio Fineschi,
Abstract This study aims to demonstrate that the application of miRNA expression in forensic pathology, in cases of hanging, applying the method on skin samples. The proposed investigative protocol allowed us to highlight a different miRNA expression in the skin ligature marks of subjects who died by hanging compared to healthy skin control samples. The results obtained showed an increase in the expression of miRNAs recognized as regulators of the inflammatory response in skin lesions such as miR125a- ...
Tópico(s): Burn Injury Management and Outcomes
2019 - Nature Portfolio | Scientific Reports
Nikolaos Angelakopoulos, Stefano De Luca, Luz Andrea Velandia Palacio, Erminia Coccia, Luigi Ferrante, Vilma Pinchi, Roberto Cameriere,
In this cross-sectional study, the accuracy of Cameriere's European formula was tested and a new specific model was developed for two samples of black and white South African children with known age and sex. For these purposes, 970 children of black South African ethnicity (girls 491, boys 479) and 974 with European ethnicity, living in South Africa (girls 493, boys 481), were retrospectively analyzed. The application of the European formula showed that there is a trend in the error estimates: the ...
Tópico(s): Dental Radiography and Imaging
2019 - Springer Science+Business Media | International Journal of Legal Medicine
Raffaele La Russa, Aniello Maiese, Rocco Valerio Viola, Alessandra De Matteis, Enrica Pinchi, Paola Frati, Vittorio Fineschi,
The autoptical observations commonly ascribed to sepsis deal with unspecific general and local signs of inflammation or ischemia, such as myocardial inflammation, pulmonary edema and infiltration, cerebral swallowing, and tubular necrosis in the kidney. In the two last decades, some studies have been carried out to implement immunohistochemical markers for post-mortem diagnosis. All of these target molecules are specifically up-regulated or down-regulated during systemic inflammatory responses, ...
Tópico(s): Neonatal and Maternal Infections
2019 - SAGE Publishing | International Journal of Immunopathology and Pharmacology
Enrica Pinchi, Luigi Cipolloni, Paola Santoro, Volonnino Gianpietro, Tomassi Raoul, Arcangeli Mauro, Paola Frati,
The acronym TBI refers to traumatic brain injury, an alteration of brain function, or an evidence of brain pathology, that is caused by an external force. TBI is estimated to become the third leading cause of permanent disability and mortality worldwide. TBI-related injuries can be classified in many ways, according to the degree of severity or the pathophysiology of brain injury (primary and secondary damage). Numerous cellular pathways act in secondary brain damage: excitotoxicity (mediated by excitatory ...
Tópico(s): Traumatic Brain Injury Research
2019 - Bentham Science Publishers | Current Neuropharmacology
Enrica Pinchi, Paola Frati, Mariarosaria Aromatario, Luigi Cipolloni, M. Fabbri, Raffaele La Russa, Aniello Maiese, Margherita Neri, Alessandro Santurro, Matteo Scopetti, Rocco Valerio Viola, Emanuela Turillazzi, Vittorio Fineschi,
Abstract MicroRNAs (miRNAs) are strongly up‐regulated under pathological stress and in a wide range of diseases. In recent years, miRNAs are under investigation for their potential use as biomarkers in cardiovascular diseases. We investigate whether specific cardio‐miRNAs are overexpressed in heart samples from subjects deceased for acute myocardial infarction (AMI) or sudden cardiac death (SCD), and whether miRNA could help differentiate between them. Forty four cases of death due to cardiovascular ...
Tópico(s): Viral Infections and Immunology Research
2019 - Wiley | Journal of Cellular and Molecular Medicine
Enrica Pinchi, Alessandro Frati, Santina Cantatore, Stefano D’Errico, Raffaele La Russa, Aniello Maiese, Mauro Palmieri, Alessandro Pesce, Rocco Valerio Viola, Paola Frati, Vittorio Fineschi,
Acute traumatic spinal cord injury (SCI) involves primary and secondary injury mechanisms. The primary mechanism is related to the initial traumatic damage caused by the damaging impact and this damage is irreversible. Secondary mechanisms, which begin as early as a few minutes after the initial trauma, include processes such as spinal cord ischemia, cellular excitotoxicity, ionic dysregulation, and free radical-mediated peroxidation. SCI is featured by different forms of injury, investigating the ...
Tópico(s): Mesenchymal stem cell research
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Maria Grazia Cagetti, P A Marcoli, Mario Berengo, Piero Cascone, Livio Cordone, Patrizia Defabianis, Osvalda De Giglio, Nicola Esposito, Antonio Federici, A Laino, Alessandra Majorana, M Nardone, Vilma Pinchi, Silvia Pizzi, Antonella Polimeni, Maria Grazia Privitera, Valentina Talarico, Stefania Zampogna,
Abstract Dental trauma is a frequent occurrence in children and adolescent and a correct diagnosis and treatment are essential for a favourable long-term prognosis. The present Guidelines aim to formulate evidence-based recommendations to assist dentists, paediatricians, surgeons, teachers, school and sport staff, parents in the prevention and first aid of dental trauma in children and to provide a careful assessment of the medico-legal implications, reviewing the first draft of the guidelines published ...
Tópico(s): Injury Epidemiology and Prevention
2019 - BioMed Central | The Italian Journal of Pediatrics/Italian journal of pediatrics
Enrica Pinchi, Alessandro Frati, Luigi Cipolloni, Mariarosaria Aromatario, Vittorio Gatto, Raffaele La Russa, Alessandro Pesce, Alessandro Santurro, Flavia Fraschetti, Paola Frati, Vittorio Fineschi,
Traumatic brain injury (TBI) is one of the most important death and disability cause, involving substantial costs, also in economic terms, when considering the young age of the involved subject. Aim of this paper is to report a series of patients treated at our institutions, to verify neurological results at six months or survival; in fatal cases we searched for βAPP, GFAP, IL-1β, NFL, Spectrin II, TUNEL and miR-21, miR-16, and miR-92 expressions in brain samples, to verify DAI diagnosis and grade ...
Tópico(s): Cancer-related molecular mechanisms research
2018 - Nature Portfolio | Scientific Reports