Mark Kerstjens, Emma M. C. Driessen, Merel Willekes, Sandra S. Pinhanços, Pauline Schneider, Rob Pieters, Ronald W. Stam,
... C. Driessen 1, * , Merel Willekes 1 , Sandra S. Pinhanços 1 , Pauline Schneider 1 , Rob Pieters 1, 2 , ...
Tópico(s): Acute Lymphoblastic Leukemia research
2016 - Impact Journals LLC | Oncotarget
Mark Kerstjens, Sandra S. Pinhanços, Patricia Garrido Castro, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam,
The majority (approx. 80%) of infant acute lymphoblastic leukemia (ALL) cases are characterized by chromosomal rearrangements involving the Mixed Lineage Leukemia ( MLL , or KMT2A ) gene, which confer a poor prognosis: chances of event-free survival are 30–40% at best.[1][1] We and others showed
Tópico(s): Chronic Myeloid Leukemia Treatments
2018 - Ferrata Storti Foundation | Haematologica
P Garrido Castro, Eddy H.J. Van Roon, Sandra S. Pinhanços, Luca Trentin, Pauline Schneider, Mark Kerstjens, Geertruy te Kronnie, Olaf Heidenreich, Rob Pieters, Ronald W. Stam,
Tópico(s): Epigenetics and DNA Methylation
2017 - Springer Nature | Leukemia
Rita Bastos, Ana Pinhanços, Mário Santos, Rui F. Fernandes, Joana R. Vicente, Francisco Morinha, João P. Honrado, Paulo Travassos, Paulo Barros, João Alexandre Cabral,
Summary The E urasian skylark A lauda arvensis is very susceptible to the negative effects of wind farms. In northern P ortugal, this evidence is particularly severe due to the skylark's preference for mountain breeding habitats where most wind farms are located. Facing the frequent failure of environmental impact assessments ( EIA ) to evaluate the cumulative impacts of wind farms on wildlife, this study aimed to develop and test a methodology to quantify local and regional consequences on birds, using ...
Tópico(s): Wildlife Ecology and Conservation
2015 - Wiley | Journal of Applied Ecology
Lucas S. Parreiras, Rebecca J. Breuer, Ragothaman Avanasi Narasimhan, Alan Higbee, Alex La Reau, Mary Tremaine, Qin Li, Laura B. Willis, Benjamin D. Bice, Brandi L. Bonfert, Rebeca C. Pinhancos, Allison J. Balloon, Nirmal Uppugundla, Tongjun Liu, Chenlin Li, Deepti Tanjore, Irene M. Ong, Haibo Li, Edward L. Pohlmann, Jose Serate, Sydnor T. Withers, Blake A. Simmons, David B. Hodge, Michael S. Westphall, Joshua J. Coon, Bruce E. Dale, Venkatesh Balan, David H. Keating, Yaoping Zhang, Robert Landick, Audrey P. Gasch, Trey K. Sato,
The inability of the yeast Saccharomyces cerevisiae to ferment xylose effectively under anaerobic conditions is a major barrier to economical production of lignocellulosic biofuels. Although genetic approaches have enabled engineering of S. cerevisiae to convert xylose efficiently into ethanol in defined lab medium, few strains are able to ferment xylose from lignocellulosic hydrolysates in the absence of oxygen. This limited xylose conversion is believed to result from small molecules generated ...
Tópico(s): Fungal and yeast genetics research
2014 - Public Library of Science | PLoS ONE
J A P Spijkers-Hagelstein, Sandra S. Pinhanços, Pauline Schneider, Rob Pieters, Ronald W. Stam,
Tópico(s): Chronic Myeloid Leukemia Treatments
2013 - Springer Nature | Leukemia
Arie J. Hoogendijk, Sandra S. Pinhanços, Tom van der Poll, Catharina W. Wieland,
Adenosine monophosphate-activated protein (AMP)-activated kinase (AMPK) is a highly conserved kinase that plays a key role in energy homeostasis. Activation of AMPK was shown to reduce inflammation in response to lipolysaccharide in vitro and in vivo. 5-Aminoimidazole-4-carbox-amide-1-β-D-ribofuranoside (AICAR) is intracellularly converted to the AMP analog ZMP, which activates AMPK. Lipoteichoic acid (LTA) is a major component of the cell wall of Gram-positive bacteria that can trigger inflammatory ...
Tópico(s): Pancreatic function and diabetes
2013 - Elsevier BV | Journal of Biological Chemistry
J A P Spijkers-Hagelstein, Sandra S. Pinhanços, Pauline Schneider, Rob Pieters, Ronald W. Stam,
Tópico(s): Cytokine Signaling Pathways and Interactions
2012 - Springer Nature | Leukemia
Rebeca Pinhancos, Sara Maass, Dil Ramanathan,
Abstract The presence of pharmaceuticals in drinking water is an emerging environmental concern. In most environmental testing laboratories, LC‐MS/MS assays based on selected reaction monitoring are used as part of a battery of tests used to assure water quality. Although LC‐MS/MS continues to be the best tool for detecting pharmaceuticals in water, the combined use of hybrid high‐resolution mass spectrometry (HRMS) and ultrahigh pressure liquid chromatography (UHPLC) is starting to become a practical ...
Tópico(s): Analytical Chemistry and Chromatography
2011 - Wiley | Journal of Mass Spectrometry
José F. Cascalheira, Sara S. João, Sandra S. Pinhanços, Rita Castro, Manuela Palmeira, Sofia Almeida, Maria C. Faria, Fernanda Domingues,
To study the interplay between serum concentrations of homocysteine, steroid hormones and vitamins B and mutations in 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, in association to Alzheimer's type dementia (ATD). Case-control study including 19 individuals diagnosed with ATD and 36 healthy controls. Serum concentrations of the analytes were determined and MTHFR 1298A → C mutation was screened by PCR-RFLP. Multivariable logistic regression analysis identified homocysteine (OR = 1.92, P < 0.01), ...
Tópico(s): Fluoride Effects and Removal
2009 - Elsevier BV | Clinical Biochemistry
J A P Spijkers-Hagelstein, Pauline Schneider, Sandra S. Pinhanços, Patricia Garrido Castro, Rob Pieters, Ronald W. Stam,
Tópico(s): CAR-T cell therapy research
2014 - Elsevier BV | European Journal of Cancer
Priscilla Wander, Susan T.C.J.M. Arentsen-Peters, Sandra S. Pinhanços, Bianca Koopmans, M. Emmy M. Dolman, Hendrikus C. R. Ariese, Frank L. Bos, Patricia Garrido Castro, Luke Jones, Pauline Schneider, Míriam Guillén Navarro, Jan J. Molenaar, Anne C. Rios, C. Michel Zwaan, Ronald W. Stam,
Pediatric MLL-rearranged acute myeloid leukemia (AML) has a generally unfavorable outcome, primarily due to relapse and drug resistance. To overcome these difficulties, new therapeutic agents are urgently needed. Yet, implementing novel drugs for clinical use is a time-consuming, laborious, costly and high-risk process. Therefore, we applied a drug-repositioning strategy by screening drug libraries, comprised of >4000 compounds that are mostly FDA-approved, in a high-throughput format on primary MLL- ...
Tópico(s): Protein Degradation and Inhibitors
2021 - Elsevier BV | Translational Oncology
Pauline Schneider, Patricia Garrido Castro, Sandra S. Pinhanços, Mark Kerstjens, Eddy HJ van Roon, Anke H. W. Essing, M. Emmy M. Dolman, Jan J. Molenaar, Rob Pieters, Ronald W. Stam,
MLL-rearranged acute lymphoblastic leukemia (ALL) represents a highly aggressive ALL subtype, characterized by aberrant DNA methylation patterns. DNA methyltransferase inhibitors, such as decitabine have previously been demonstrated to be effective in eradicating MLL-rearranged ALL cells in vitro. Here, we assessed the in vivo anti-leukemic potential of low-dose DNA methyltransferase inhibitor decitabine using a xenograft mouse model of human MLL-rearranged ALL. Furthermore, we explored whether prolonged ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Wiley | eJHaem
Emma M. C. Driessen, Sandra S. Pinhanços, Pauline Schneider, Paola De Lorenzo, Maria Grazia Valsecchi, Rob Pieters, Ronald W. Stam,
Acute lymphoblastic leukaemia (ALL) in infants (<1 year) is an aggressive disease, associated with poor clinical outcome [ [1] Biondi A. Cimino G. Pieters R. Pui C.H. Biological and therapeutic aspects of infant leukemia. Blood. 2000; 96: 24-33 PubMed Google Scholar ]. Infant ALL is associated with high incidence of MLL translocations, which are independent predictors of an adverse outcome [ 1 Biondi A. Cimino G. Pieters R. Pui C.H. Biological and therapeutic aspects of infant leukemia. Blood. 2000; 96: 24- ...
Tópico(s): Glycosylation and Glycoproteins Research
2016 - Elsevier BV | European Journal of Cancer
Priscilla Wander, Susan T.C.J.M. Arentsen-Peters, Kirsten S. Vrenken, Sandra S. Pinhanços, Bianca Koopmans, M. Emmy M. Dolman, Luke Jones, Patricia Garrido Castro, Pauline Schneider, Mark Kerstjens, Jan J. Molenaar, Rob Pieters, C. Michel Zwaan, Ronald W. Stam,
KMT2A-rearranged acute lymphoblastic leukemia (ALL) in infants (<1 year of age) represents an aggressive type of childhood leukemia characterized by a poor clinical outcome with a survival chance of <50%. Implementing novel therapeutic approaches for these patients is a slow-paced and costly process. Here, we utilized a drug-repurposing strategy to identify potent drugs that could expeditiously be translated into clinical applications. We performed high-throughput screens of various drug libraries, ...
Tópico(s): Acute Myeloid Leukemia Research
2022 - Multidisciplinary Digital Publishing Institute | Biomedicines
Mark Kerstjens, Patricia Garrido Castro, Sandra S. Pinhanços, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam,
Acute lymphoblastic leukemia (ALL) in infants (<1 year of age) remains one of the most aggressive types of childhood hematologic malignancy. The majority (~80%) of infant ALL cases are characterized by chromosomal translocations involving the MLL (or KMT2A) gene, which confer highly dismal prognoses on current combination chemotherapeutic regimens. Hence, more adequate therapeutic strategies are urgently needed. To expedite clinical transition of potentially effective therapeutics, we here applied a drug ...
Tópico(s): Lung Cancer Research Studies
2021 - Multidisciplinary Digital Publishing Institute | Biomedicines
Inês Ramos Rego, Daniela Silvério, Maria Isabel Eufrásio, Sandra S. Pinhanços, Bruna Lopes da Costa, José Teixeira, Hugo Fernandes, Yang Kong, Yao Li, Stephen H. Tsang, Paulo J. Oliveira, Rosa Fernandes, Peter M. J. Quinn, Paulo F. Santos, António Francisco Ambrósio, C. Henrique Alves,
Age-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment epithelium (RPE) triggered by oxidative stress plays a central role in the onset and progression of AMD and results from the excessive accumulation of reactive oxygen species (ROS) produced mainly by mitochondria. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial molecular chaperone that contributes to the maintenance ...
Tópico(s): Autophagy in Disease and Therapy
2023 - Multidisciplinary Digital Publishing Institute | Antioxidants
Priscilla Wander, Laurence C. Cheung, Sandra S. Pinhanços, Luke Jones, Mark Kerstjens, Susan T.C.J.M. Arentsen-Peters, Sajla Singh, Grace-Alyssa Chua, Patricia Garrido Castro, Pauline Schneider, M. Emmy M. Dolman, Bianca Koopmans, Jan J. Molenaar, Rob Pieters, C. Michel Zwaan, Rishi S. Kotecha, Ronald W. Stam,
Tópico(s): Childhood Cancer Survivors' Quality of Life
2020 - Springer Nature | Leukemia
Rosângela Bertelli, José João Pinhanços de Bianchi, Eduardo Chaves Cruz,
Malignant forms of cognitive decline are caused by a variety of neuropathological conditions. Dementia with Lewy bodies (DLB) is among such conditions. Even though such a condition represents the second most frequent cause of neurodegenerative dementia in elderly people, it is still very little known by psychologists. Psychologists can play a very important role in the process of cognitive evaluation and differential diagnosis between this neurodegenerative condition and neuropsychiatric conditions. ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2009 - Desafio Singular | Motricidade
Awbath Saleh, A. El.Fiki, José Manuel Pose Rodríguez, S. Laroche, K.Y. Castor, Daniel Marín, Tiago Luís Cardoso Ferreira Pinhanços de Bianchi, Philìppe Bertrand, P. Herrmann,
Summary Land Seismic value has drastically improved with the addition of two key ingredients at the acquisition stage which have significantly increased the geophysical information captured in the seismic recordings. The first one, on the seismic source side, corresponds to the broadening of the seismic bandwidth with the addition of at least two octaves at the low frequency side of the spectrum, thanks to advances in seismic vibrator technology. These additional low frequencies reveal deep structures ...
Tópico(s): Seismology and Earthquake Studies
2017 - | Proceedings
Priscilla Wander, Sandra S. Pinhanços, Bianca Koopmans, M. Emmy M. Dolman, Pauline Schneider, Patricia Garrido Castro, Luke Jones, Susan T.C.J.M. Arentsen-Peters, Mark Kerstjens, Jan J. Molenaar, Huib N. Caron, Rob Pieters, Michel Zwaan, Ronald W. Stam,
... childhood leukemia. Citation Format: Priscilla Wander, Sandra S. Pinhanços, Bianca Koopmans, M. Emmy M. Dolman, Pauline Schneider, ...
Tópico(s): Protein Degradation and Inhibitors
2018 - American Association for Cancer Research | Cancer Research
Arie J. Hoogendijk, Sandra S. Pinhanços, Tom van der Poll, Catharina W. Wieland,
Gram-positive and gram-negative bacteria are common causative agents of respiratory tract infection. Lipopolysaccharide (LPS) is a component of the gram-negative cell wall and a strong inducer of inflammation. The main proinflammatory component of the gram-positive bacterial cell wall is lipoteichoic acid (LTA). The protein kinase p38 mitogen activated protein kinase (MAPK) plays an important role in the inflammatory process induced by these two bacterial structures.We here sought to establish the ...
Tópico(s): Melanoma and MAPK Pathways
2012 - Elsevier BV | Immunobiology
... in August 1603. Another Portuguese individual, Diogo Lopes Pinhanços, was burned at the stake in Coimbra of ...
Tópico(s): Historical and Linguistic Studies
2009 - The Catholic University of America Press | The Catholic historical review
Sandra S. Pinhanços, Joana Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J. J. de Winter, Sofia Viana, Flávio Reis, Jorge Francisco Kuhn dos Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferreira, Martin Gotthardt, John G. Jones, Hugo Fernandes,
Tópico(s): Diet, Metabolism, and Disease
2025 - Cell Press | Molecular Therapy — Nucleic Acids
Joana Oliveira, S. Pinhanços, Tiago Correia, Isabel Mesquita, Miguel Marcos, Paulo Soares, J. Jones, Hugo Fernandes, J. Santos,
Tópico(s): Cardiovascular Disease and Adiposity
2024 - Elsevier BV | Diabetes Research and Clinical Practice
S. Pinhanços, Joana Oliveira, J. Santos, M. Gotthard, Lino Ferreira, J. Jones, Hugo Fernandes,
Tópico(s): Endoplasmic Reticulum Stress and Disease
2023 - Elsevier BV | Diabetes Research and Clinical Practice
Tamara Verbeek, Susan T.C.J.M. Arentsen-Peters, Patricia Garrido Castro, Sandra S. Pinhanços, Kirsten S. Vrenken, Aida Varela-Moreira, M. Emmy M. Dolman, Bianca Koopmans, Rob Pieters, Ronald W. Stam,
Abstract MLL-rearranged acute lymphoblastic leukemia (ALL) is characterized by deregulation of the epigenome and shows susceptibility towards epigenetic perturbators such as histone deacetylase (HDAC) inhibitors. Hence, HDACs represent attractive drug targets and a variety of small molecule HDAC inhibitors have been developed and evaluated for the treatment of hematological malignancies. However, most broad-spectrum inhibitors, which simultaneously target the majority of human HDAC isoforms, often ...
Tópico(s): Protein Degradation and Inhibitors
2021 - Elsevier BV | Blood
Tiago Luís Cardoso Ferreira Pinhanços de Bianchi, Henrique Vieira Tozzi, Carim Rodrigues, Beatriz Viégas-Faria, Maiara Almeida Porto,
Prologo de Tiago Bianchi. O tunante. Traducao de Henrique Vieira Tozzi, revisada por Beatriz Viegas-Faria, Fabiana Kanan Oliveira e Liziane Kuglang de Souza. A Torre das Infantas. Traducao de Carim Rodrigues e Beatriz Viegas-Faria. Revisao de traducao de Tiago Bianchi e Liziane Kugland de Souza. A lenda das tres belas princesas. Traducao de Maiara Almeida Porto e Beatriz Viegas-Faria. Revisao de traducao de Liziane Kugland de Souza e Daniel Soares Duarte.
Tópico(s): Cultural, Media, and Literary Studies
2018 - UNIVERSIDADE FEDERAL DE SANTA CATARINA | Cadernos de Tradução
Patricia Garrido Castro, Mark Kerstjens, Sandra S. Pinhanços, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam,
Abstract BACKGROUND: Acute lymphoblastic leukemia (ALL) in infants (diagnosis AIM: While novel drug classes have shown pre-clinical promise in MLL -R ALL, clinical implementation has become a major bottle-neck, as set-up of clinical trials with new drugs, as well as their FDA-approval, is a protracted process. Hence, we explored a drug repurposing approach, performing screens of >3000 FDA-approved drugs to identify compounds able to both target MLL -RALL cells and expeditiously transition into clinics. ...
Tópico(s): Lung Cancer Research Studies
2017 - Elsevier BV | Blood
Rebeca C. Pinhancos, Hannah Bowman, Matthew R. Dent, Byron H. Young, Christopher Berndsen, Judith N. Burstyn,
The gases NO, O 2 , CO and H 2 S are small‐molecule effectors involved in signaling pathways. Heme serves as an effector‐binding site in many proteins that sense these molecules, including gas‐sensing transcription factors, and the effector‐binding signal is transduced through varying allosteric mechanisms. Bacterial transcription factors are excellent systems in which to study gas‐mediated allostery due to their simplicity relative to the multi‐protein complexes involved in eukaryotic transcription. ...
Tópico(s): Microbial Fuel Cells and Bioremediation
2017 - Wiley | The FASEB Journal