Paula David, Andrea Di Matteo, Or Hen, Shouvik Dass, Helena Marzo‐Ortega, Richard J. Wakefield, Leslie‐Anne Bissell, Jacqueline Nam, Kulveer Mankia, Paul Emery, Benazir Saleem, Dennis McGonagle,
... investigate whether patients with persistent inflammatory refractory RA (PIRRA) and noninflammatory refractory RA (NIRRA), determined by objective ... to at least one drug of all classes. PIRRA was defined if US synovitis in one or ... conducted to investigate factors associated with poly‐refractory, PIRRA, and NIRRA phenotypes. Results 122 of 1,591 ... D2T‐RA with recent US, 61 (57%) were PIRRA and 46 (43%), NIRRA. Patients with NIRRA had ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2023 - Wiley | Arthritis & Rheumatology
Alessandro Giollo, Margherita Zen, Maddalena Larosa, D. Astorri, Mariangela Salvato, Antonia Calligaro, K. Botsios, Cristina De Bernardi, Gerolamo Bianchi, Andrea Doria,
... factors were associated with persistent inflammatory refractory RA (PIRRA) or non-inflammatory refractory RA (NIRRA). Sensitivity analysis ... D2T-RA. Treatment delay was significantly associated with PIRRA only, while non-discontinuation of glucocorticoids was significantly associated with PIRRA and NIRRA. Results were replicated in sensitivity analyses. ...
Tópico(s): Systemic Lupus Erythematosus Research
2022 - Oxford University Press | Lara D. Veeken
John Y. Campbell, Robert J. Shiller,
... 020-09781-1Domenico De Giovanni, Arturo Leccadito, Marco Pirra On the determinants of data breaches: A cointegration ...
Tópico(s): Energy, Environment, Economic Growth
1987 - University of Chicago Press | Journal of Political Economy
Roberto Gómez, G. Pirra, Miguel A. Cannata,
Experiments were conducted in normal Wistar rats with different patterns of behavior to assess the effects of stress on cardiovascular reactivity. One week after weaning and one month later rats were tested in an open field. Animals that did not cross any square in both open fields were classified as HYPOACTIVE. Those crossing more than 43 squares in the first and any in the second open field were classified as HYPERACTIVE. No difference was found in the basal mean blood pressure (BP) or heart rate ( ...
Tópico(s): Biochemical effects in animals
1989 - Elsevier BV | Physiology & Behavior
Muriel Tavaud-Pirra, Pascal Sartre, Randall L. Nelson, Sylvain Santoni, N. Texier, Pierre Roumet,
Soybean [ Glycine max (L.) Merr.] was domesticated in China, and cultivated landraces were initially distributed throughout Asia and more recently extended to Europe and America. Previous studies of genetic diversity suggest a strong genetic bottleneck between Asian and North American soybean genetic pools. However, little is known about the potentially useful genetic diversity present in European soybean germplasm. We evaluated genetic diversity by phenotypic characterization and by comparing nuclear ...
Tópico(s): Plant pathogens and resistance mechanisms
2009 - Wiley | Crop Science
Marco S. Lucas, Maria Mouta, António Pirra, José A. Peres,
The degradation of the organic pollutants present in winery wastewater was carried out by the combination of two successive steps: an aerobic biological process followed by a chemical oxidation process using Fenton's reagent. The main goal of this study was to evaluate the temporal characteristics of solids and chemical oxygen demand (COD) present in winery wastewater in a long term aerated storage bioreactor. The performance of different air dosage daily supplied to the biologic reactor, in laboratory ...
Tópico(s): Water Quality Monitoring Technologies
2009 - Pergamon Press | Water Science & Technology
Akanchha Kesari, Laura Pirra, Lakshmi Bremadesam, Orinthal McIntyre, Erynn S. Gordon, Alberto Dubrovsky, Venkatarman Viswanathan, Eric P. Hoffman,
Becker muscular dystrophy (BMD) is a milder form of X-linked Duchenne muscular dystrophy (DMD). Here, we report a study of 75 patients with immunoblot and/or immunostaining findings of muscle biopsy consistent with BMD (abnormal dystrophin). We utilized multiplex ligation dependent probe amplification (MLPA) on genomic DNA (gDNA) to screen all 79 exons for both deletions and duplications. A total of 19 patients testing negative for MLPA mutations were tested for mRNA splicing abnormalities using cDNA- ...
Tópico(s): Genetic Neurodegenerative Diseases
2008 - Wiley | Human Mutation
Akanchha Kesari, Mitsunori Fukuda, Susan M. Knoblach, Rumaisa Bashir, Gustavo A. Nader, Deepak A. Rao, Kanneboyina Nagaraju, Eric P. Hoffman,
... and dysferlin immunoblotting, as previously described.19Kesari A Pirra LN Bremadesam L McIntyre O Gordon E Dubrovsky ...
Tópico(s): Cellular transport and secretion
2008 - Elsevier BV | American Journal Of Pathology
Rui Braz, António Pirra, Marco S. Lucas, José A. Peres,
Winery wastewaters from white and red wine production were studied, in the first stage of this work, by a coagulation/flocculation process using four different coagulants (FeSO4, Al2(SO4)3, FeCl3 and Ca(OH)2). The optimal pH and volume of coagulant added were studied. From the results achieved it was possible to verify that coagulation/flocculation allows, within optimal conditions of pH and coagulant dosage, an efficient removal of turbidity (aluminium sulphate, 92.6%) and total suspended solids — ...
Tópico(s): Membrane Separation Technologies
2010 - Elsevier BV | Desalination
Jacques David, Yan Holtz, Vincent Ranwez, Sylvain Santoni, Guillaume Sarah, Morgane Ardisson, Gérard Poux, Frédéric Choulet, Clémence Genthon, Pierre Roumet, Muriel Tavaud-Pirra,
Tópico(s): Genetics and Plant Breeding
2014 - Springer Science+Business Media | Molecular Breeding
Enrico Bertino, Francesca Giuliani, Marta Baricco, Paola Di Nicola, Chiara Peila, Cristina Vassia, Federica Chiale, Alice Pirra, Francesco Cresi, C Martano, Alessandra Coscia,
Mother's own milk is widely recognized as the optimal feeding for term infants, but also provides health benefits that are of vital importance for sick and preterm infants in neonatal intensive care units (NICUs), even though the growth and neurodevelopmental needs of very premature infants are best met by appropriate fortification of human milk (HM). When mother's milk is unavailable or in short supply, donor milk (DM) represents the second best alternative and, although some nutritional elements ...
Tópico(s): Neonatal Respiratory Health Research
2013 - Elsevier BV | Early Human Development
Michael J. B. Krieger, Andreas Roos, Claudia Stendel, Kristl G. Claeys, Fatma Müjgan Sönmez, Michael Baudis, Peter Bauer, Antje Bornemann, Christian de Goede, Andreas Dufke, Richard S. Finkel, Hans H. Goebel, Martin Häussler, Helen Kingston, Janbernd Kirschner, Līvija Medne, Petra Muschke, François Rivier, Sabine Rudnik‐Schöneborn, Sabrina Spengler, Francesca Inzana, Franco Stanzial, Francesco Benedicenti, Matthis Synofzik, Ana Lía Taratuto, Laura Pirra, S K Tay, Haluk Topaloğlu, Gökhan Uyanık, Dorothea Wand, Denise Williams, Klaus Zerres, Joachim Weis, Jan Senderek,
Marinesco-Sjögren syndrome is a rare autosomal recessive multisystem disorder featuring cerebellar ataxia, early-onset cataracts, chronic myopathy, variable intellectual disability and delayed motor development. More recently, mutations in the SIL1 gene, which encodes an endoplasmic reticulum resident co-chaperone, were identified as the main cause of Marinesco-Sjögren syndrome. Here we describe the results of SIL1 mutation analysis in 62 patients presenting with early-onset ataxia, cataracts and ...
Tópico(s): Protein Tyrosine Phosphatases
2013 - Oxford University Press | Brain
Pedro N. Carvalho, António Pirra, M. Clara P. Basto, C. Marisa R. Almeida,
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2013 - Springer Science+Business Media | Environmental Science and Pollution Research
Vincent Ranwez, Yan Holtz, Gautier Sarah, Morgane Ardisson, Sylvain Santoni, Sylvain Glémin, Muriel Tavaud-Pirra, Jacques David,
Using Next Generation Sequencing, SNP discovery is relatively easy on diploid species and still hampered in polyploid species by the confusion due to homeology. We develop HomeoSplitter; a fast and effective solution to split original contigs obtained by RNAseq into two homeologous sequences. It uses the differential expression of the two homeologous genes in the RNA. We verify that the new sequences are closer to the diploid progenitors of the allopolyploid species than the original contig. By ...
Tópico(s): Chromosomal and Genetic Variations
2013 - BioMed Central | BMC Bioinformatics
The study of how people jointly use different travel means is one of the key issues in contemporary transport research. However, measuring multimodality behaviours presents some intricacies that deserve more attention in order to come up with an instrument that is effective both on a modelling and on a policy viewpoint. The present work considers some methods that have been proposed in different disciplinary ambits to measure diversity and assesses to what extent they are useful to measure multimodality. ...
Tópico(s): Economic and Environmental Valuation
2016 - Taylor & Francis | Transportmetrica A Transport Science
Luciana León Cejas, Daniela Binaghi, Mariano Socolovsky, Alberto Dubrovsky, Laura Pirra, Cintia Marchesoni, Ana Pardal, Soledad Monges, Gabriela Peretti, Ana Lía Taratuto, Fabiana Lubinieki, Ricardo Reisin,
Intraneural perineurioma (IP) is an under-recognized hypertrophic peripheral nerve tumor. It affects young patients involving frequently the sciatic nerve and its branches and presents with a progressive, painless and predominantly motor deficit. Magnetic resonance neurography (MRN) is a useful tool to localize the lesion, evaluate its extension, and discriminate between different etiologies. We reviewed the clinical records of 11 patients with pathologically confirm IP. Eight patients were males ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2017 - Wiley | Journal of the Peripheral Nervous System
Yusak O. Susilo, Andrée Woodcock, Fotis K. Liotopoulos, André Luís Faria Duarte, Jane Osmond, Roberto F. Abenoza, Lucian Emanuel Anghel, Dolores Herrero, Federico Fornari, Virginie Tolio, Eileen O’Connell, Ieva Markucevičiūtė, Chrysoula Kritharioti, Miriam Pirra,
This study describes the lessons learned from designing, deploying and analysing the results from different travel satisfaction survey tools which measures the travellers' door-to-door travel satisfaction. The travel satisfaction measurement survey tools tested consisted of two types of smartphone applications (a satellite navigation app and a game app), an on-line survey, a paper-based semi-structured questionnaire and a focus group questionnaire. Each of the measurement tools comprised the same ...
Tópico(s): Customer Service Quality and Loyalty
2017 - Elsevier BV | Transportation research procedia
A new approach in recognizing travel mode choice patterns is proposed, based on the Support Vector Machine classification technique. The tour-based travel demand dataset that is analysed is for New York State, derived from the 2009 U.S. National Household Travel Survey. The main features characterizing each tour are the means used, travel-related variables and socioeconomic aspects. Results obtained demonstrate the ability to predict to some extent, in real settings where car use dominates, which ...
Tópico(s): Urban Transport and Accessibility
2018 - Taylor & Francis | Transportation Planning and Technology
Sabrina Semitela, António Pirra, Fernando G. Braga,
In this study, different amounts of a mixture of winery waste activated sludge and grape stalks were co-composted for 8 weeks, at lab-scale under different temperatures and aeration rates, and at pilot-scale. None of the experiments showed the occurrence of a thermophilic stage, even when the composting temperature was kept at 34 °C, which might suggest biological suppression by the acclimated mesophilic microorganisms ubiquitous to the winery waste activated sludge. The composted substrates were ...
Tópico(s): Constructed Wetlands for Wastewater Treatment
2019 - Elsevier BV | Bioresource Technology
Miriam Pirra, Ruggero G. Pensa,
The quality of the transport system offered at city level constitutes an important and challenging goal for society, for local authorities, and transport operators. Therefore, appropriate evaluation of travellers’ satisfaction is required to support service performance monitoring, benchmarking, and market analysis. This aspect implies the collection of satisfaction levels for different passengers’ groups, as it could provide interesting suggestions for identifying priority areas of action. To this ...
Tópico(s): Sensory Analysis and Statistical Methods
2019 - Multidisciplinary Digital Publishing Institute | Sustainability
Cristina Matos, António Pirra,
Wine production, one of the oldest industries in the world is an industry for which water use in winery operations is often disregarded of best practice, with many managers unconscious how water is used within their operations. Given the economic and cultural significance attributed to wine production in Portugal and in the world, it is crucial that research be undertaken to understand how water is used in wine industry in order to increase the efficient use of this vital resource. The study aimed ...
Tópico(s): Fermentation and Sensory Analysis
2020 - Elsevier BV | The Science of The Total Environment
Martín Gómez-Ullate García de León, Laurent Rieutort, Afroditi Kamara, Ana Sofía Santos, António Pirra, Merly Gotay Solís,
Abstract The project Cultrural+ (an Erasmus+ Strategic Partnership project in the field of Adult Education) is funding research and education to deal with major demographic challenges in some regions of the participant countries (Extremadura in Spain, Tràsos-Montes in Portugal, Central Massif in France, Thessaly in Greece and province of Latina in Italy). The paper will discuss the particular problems that European depopulated areas are facing and how cultural heritage and cultural tourism could act ...
Tópico(s): Sustainable Urban and Rural Development
2020 - De Gruyter Open | European Countryside
Marco Diana, Miriam Pirra, Andrée Woodcock,
Abstract Cities all around the world are observing increasing levels of urban freight activities owing to the growth of internet shopping combined to the traditional distribution to shops, creating additional problems in terms of congestions and environmental impacts. This study, developed within the European Project SUITS framework, aims at showing how Local Authorities can effectively observe freight flows from the demand side. This led to the design, implementation and testing of a spatial cluster ...
Tópico(s): Urban Transport and Accessibility
2020 - Springer Science+Business Media | European Transport Research Review
Francesco Cresi, Elena Maggiora, Alice Pirra, Paola Tonetto, Carlotta Rubino, Laura Cavallarin, Marzia Giribaldi, Guido E. Moro, Chiara Peila, Alessandra Coscia,
Background: Feeding intolerance is a frequent diagnosis in very preterm infants. As seen in the FortiLat trial, human milk fortification with the new donkey milk-derived human milk fortifier (DF) seems to improve feeding tolerance in these infants. The aim of this study was to evaluate the effects of using the DF compared with bovine milk-derived fortifier (BF) on gastroesophageal reflux (GER) in very low birth weight (VLBW) infants. Methods: Over a total of 156 preterm infants were enrolled into the ...
Tópico(s): Gastroesophageal reflux and treatments
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Miriam Pirra, Sofia Kalakou, Angela Carboni, Mariana Costa, Marco Diana, Ana Lynce,
As sustainability is becoming a common practice in planning transport systems and mobility services, the designation and management of gender issues are of paramount importance. TInnGO is a European Project that has developed a network of 10 national Hubs to build the capacity to generate and apply evidence on gender equality and transport issues at the European level. This paper presents the project activities by introducing a relevant framework and exploring user mobility experiences based on ...
Tópico(s): Transportation Planning and Optimization
2021 - Multidisciplinary Digital Publishing Institute | Sustainability
Edward M. J. Blackwood, Karajarri Rangers, Sam Bayley, H.U. Bijlani, R. J. Fensham, Malcolm Lindsay, Ewan Noakes, Jackie Wemyss, Sarah Legge,
Summary Traditional fire practices in Australia’s deserts may have created mosaics of post‐fire seral stages that benefitted some plants and animals. Managing fire to emulate the patterns produced by traditional burning practices is a common objective in contemporary conservation planning in Australia’s deserts. However, the extent to which traditional burning in deserts affected fire regimes across space and time is contested. We aim to contribute to knowledge about the impacts of traditional burning ...
Tópico(s): Coastal wetland ecosystem dynamics
2022 - Wiley | Ecological Management & Restoration
Pedro N. Carvalho, António Pirra, M. Clara P. Basto, C. Marisa R. Almeida,
Veterinary drugs are still poorly studied in terms of pathways, release rates and effects on the environment. So, it is necessary to determine their levels in sewage sludge and soil/sediments affected by wastewaters. However, published methodologies deal usually with compounds from only a few classes. In addition, there is a lack of comparisons among the different extraction technologies used. A multi-family methodology for the simultaneous determination of minocycline, oxytetracycline, tetracycline ( ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2013 - Royal Society of Chemistry | Analytical Methods
Flávio C. Silva, António Pirra, Juan Manuel Vieites Baptista de Sousa, Luís Arroja, Isabel Capela,
Tópico(s): Water Quality Monitoring and Analysis
2012 - Croatian Society of Chemical Engineers | Chemical and Biochemical Engineering Quarterly
Massimiliano Bergallo, Ilaria Galliano, Valentina Daprà, Alice Pirra, Paola Montanari, Marzia Pavan, Cristina Calvi, Enrico Bertino, Alessandra Coscia, Pier‐Angelo Tovo,
Transcription of human endogenous retrovirus (HERV) elements is usually suppressed by epigenetic factors such as DNA methylation and heterochromatin silencing by histone modifications. There is an association between maternal smoking during pregnancy and DNA methylation levels in placental tissue and in DNA from cord blood.We assessed the transcriptional activity of HERV-H, HERV-K, and HERV-W in umbilical cord blood from 47 term babies unexposed to tobacco smoke in utero and 23 term babies exposed ...
Tópico(s): CRISPR and Genetic Engineering
2018 - Thieme Medical Publishers (Germany) | American Journal of Perinatology
Traffic congestion is a large-scale problem in urban areas all over the world that can lead to substantial costs for travellers and business operations. This paper focus on how to measure the way in which congestion selectively affects different traffic streams, with special emphasis on light duty vehicles travelling around a city. The idea is to integrate a dataset collecting Global Positioning System (GPS) vehicle traces with road side data sources related to traffic conditions in a road network, ...
Tópico(s): Human Mobility and Location-Based Analysis
2019 - Springer Science+Business Media | European Transport Research Review