Produção Nacional
Revisado por pares
Raquel Carvalho, Ronaldo A. Ribeiro, Ryan A. Falcão, Rodrigo C. Lima, Renata Ferreira de Carvalho Leitão, Cirle Alcantara, Marcellus Henrique Loiola Ponte de Souza, Fernando Q. Cunha, Gerly Anne de Castro Brito,
Tópico(s): Mast cells and histamine
2006 - Elsevier BV | European Journal of Pharmacology
Produção Nacional
Revisado por pares
Maurício L. Barreto, Sérgio Souza da Cunha, Neuza Maria Alcântara‐Neves, Lain Pontes de Carvalho, Álvaro A. Cruz, Renato T. Stein, Bernd Genser, Philip J. Cooper, Laura C. Rodrigues,
The prevalence of asthma and allergic diseases has increased in industrialised countries, and it is known that rates vary according whether the area is urban or rural and to socio-economic status. Surveys conducted in some urban settings in Latin America found high prevalence rates, only exceeded by the rates observed in industrialised English-speaking countries. It is likely that the marked changes in the environment, life style and living conditions in Latin America are responsible for these observations. ...
Tópico(s): Air Quality and Health Impacts
2006 - BioMed Central | BMC Pulmonary Medicine
Produção Nacional
Enrique Medina‐Acosta, Antónia Maria Ramos Franco, Ana María Jansen, Marcos Sampol, Neuza Maria Alcântara Neves, Lain Pontes–de-Carvalho, Gabriel Grimaldi, Victor Nussenzweig,
The expression of trans-sialidase and sialidase activities in the kinetoplastid protozoa was explored as a potential marker to discriminate between the morphologically indistinguishable flagellates isolated from human, insects and vertebrate reservoir hosts. By virtue of the differences observed in the ratios of these enzyme activities, a collection of 52 species and strains comprising the major taxa of these parasites could be separated into four expression types. Type-I parasites express comparable ...
Tópico(s): Insect symbiosis and bacterial influences
1994 - Wiley | European Journal of Biochemistry
Produção Nacional
Revisado por pares
Ana Tereza Cerqueira Lima, Neuza Maria Alcântara‐Neves, Lain Carlos Pontes de Carvalho, Ryan Santos Costa, José Maria Barbosa‐Filho, Márcia Regina Piuvezam, Momtchilo Russo, Renato Barboza, Eduardo de Jesus Oliveira, Alexsandro Fernandes Marinho, Camila Alexandrina Figueiredo,
Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as "Jarrinha"or "Milona", is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. ...
Tópico(s): Ginseng Biological Effects and Applications
2010 - Bentham Science Publishers | Current Drug Targets
Produção Nacional
Revisado por pares
Ryan Santos Costa, Tamires Cana Brasil Carneiro, Ana Tereza Cerqueira Lima, Norma Vilany Queiroz, Neuza Maria Alcântara‐Neves, Lain Carlos Pontes-de-Carvalho, Eudes da Silva Velozo, Eduardo de Jesus Oliveira, Camila Alexandrina Figueiredo,
Allergic asthma has emerged as an important public health problem of urban populations in developed countries. Very often herbal medicine is used to treat this widespread disease, due to the lack of efficacy and the important side effects related to the classical drugs in use. Along this line, Ocimum gratissimum (Og) is a plant widely used in Brazilian folk medicine to treat inflammatory disorders, such as asthma. In the present study we evaluated the immunomodulatory effects of Og and rosmarinic ...
Tópico(s): Essential Oils and Antimicrobial Activity
2012 - Elsevier BV | International Immunopharmacology
Produção Nacional
Revisado por pares
Philip J. Cooper, Martha Chico, Maritza Vaca, Alejandro Rodríguez, Neuza Maria Alcântara‐Neves, Bernd Genser, Lain Pontes de Carvalho, Renato T. Stein, Álvaro A. Cruz, Laura C. Rodrigues, Maurício L. Barreto,
Asthma and allergic diseases are becoming increasingly frequent in children in urban centres of Latin America although the prevalence of allergic disease is still low in rural areas. Understanding better why the prevalence of asthma is greater in urban migrant populations and the role of risk factors such as life style and environmental exposures, may be key to understand what is behind this trend. The Esmeraldas-SCAALA (Social Changes, Asthma and Allergy in Latin America) study consists of cross- ...
Tópico(s): Noise Effects and Management
2006 - BioMed Central | BMC Pulmonary Medicine
Produção Nacional
Kelina Bernardo Silva, Edna Ursulino Alves, Riselane de Lucena Alcântara Bruno, Valderez Pontes Matos, Edilma Pereira Gonçalves,
O conhecimento dos aspectos morfológicos de sementes e plântulas pode ser usado em estudos de taxonomia, na interpretação de testes de germinação em laboratório, trabalhos em viveiro e em estudos relacionados à ecologia da espécie. Os objetivos deste trabalho foram o de descrever e ilustrar a morfologia externa e interna dos frutos e sementes, as fases de germinação, a plântula e as plantas de mulungu (Erythrina velutina Willd.). Os frutos e sementes foram coletados no solo, embaixo de árvores matrizes ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2008 - SciELO | Revista Brasileira de Sementes
Produção Nacional
Revisado por pares
Luciana Souza de Aragão-França, Viviane C. J. Rocha, André Cronemberger Andrade, Fábio Henrique Brasil da Costa, Juliana Fraga Vasconcelos, Daniel Abensur Athanazio, Daniela Nascimento Silva, Everaldo Silvino dos Santos, Cássio Santana Meira, Cintia Figueiredo de Araújo, Jéssica Vieira Cerqueira, Fabı́ola Cardillo, Neuza Maria Alcântara‐Neves, Milena Botelho Pereira Soares, Lain Carlos Pontes-de-Carvalho,
The use of tolerogenic dendritic cells (TolDCs) to control exacerbated immune responses may be a prophylactic and therapeutic option for application in autoimmune and allergic conditions. The objective of this work was to evaluate the effects of TolDC administration in a mouse model of allergic airway inflammation caused by mite extract.Mouse bone marrow-derived TolDCs were induced by incubation with granulocyte-macrophage colony-stimulating factor (GM-CSF) and dexamethasone, and then characterized ...
Tópico(s): Immunotherapy and Immune Responses
2018 - | Allergy Asthma and Immunology Research
Produção Nacional
Revisado por pares
Tiana Baqueiro, Momtchilo Russo, Virgínia MG Silva, Thayna Meirelles, Pablo RS Oliveira, E. Gomes, Renato Barboza, Ana Tereza Cerqueira Lima, Camila Alexandrina Figueiredo, Lain Pontes–de-Carvalho, Neuza Maria Alcântara‐Neves,
The dust mite Blomia tropicalis is an important source of aeroallergens in tropical areas. Although a mouse model for B. tropicalis extract (BtE)-induced asthma has been described, no study comparing different mouse strains in this asthma model has been reported. The relevance and reproducibility of experimental animal models of allergy depends on the genetic background of the animal, the molecular composition of the allergen and the experimental protocol. This work had two objectives. The first ...
Tópico(s): Plant Toxicity and Pharmacological Properties
2010 - BioMed Central | Respiratory Research
Produção Nacional
Revisado por pares
João CM Ponte, Samuel B Junqueira, Rafael Veiga, Maurício L. Barreto, Lain Carlos Pontes-de-Carvalho, Neuza Maria Alcântara‐Neves,
Abstract Background Two conditions are used as markers of atopy: the presence of circulating anti-allergen IgE antibodies and the presence of positive skin prick test (SPT) reactions to allergenic extracts. The correlation between these conditions is not absolute. This study aimed at investigating immunological parameters that may mediate this lack of correlation. Individuals whose sera contained anti- B. tropicalis extract IgE antibodies (α -Bt E IgE) were divided into two groups, according to the ...
Tópico(s): Food Allergy and Anaphylaxis Research
2011 - BioMed Central | BMC Immunology
Produção Nacional
Revisado por pares
Kelina Bernardo Silva, Edna Ursulino Alves, Riselane de Lucena Alcântara Bruno, Valderez Pontes Matos,
Estudos que visam ao conhecimento da morfologia de sementes e plântulas contribuem para a identificação das espécies, facilitando o reconhecimento das fases iniciais do seu desenvolvimento. Assim, os objetivos deste trabalho foram caracterizar morfologicamente as estruturas externa e interna dos frutos e das sementes de Sideroxylon obtusifolium (Roem. e Schult.) Penn., além de descrever e ilustrar a morfologia externa da plântula. Para a descrição dos frutos foram observados detalhes externos e internos ...
Tópico(s): Soil Management and Crop Yield
2012 - Sociedade de Investigações Florestais | Revista Árvore
Produção Nacional
Revisado por pares
Kellyanne dos Anjos Carvalho, Osvaldo P. de Melo Neto, Franklin Barbalho Magalhães, João Carlos Marques Ponte, Filipe Adriano Borba Felipe, Mariese Conceição Alves dos Santos, Givaneide dos Santos Lima, Álvaro A. Cruz, Carina S. Pinheiro, Lain Carlos Pontes-de-Carvalho, Neuza Maria Alcântara‐Neves,
Abstract Background Blomia tropicalis is a dust mite and an important source of allergens in tropical regions. Up to now, the assays to diagnose atopy to this mite use whole body extract as antigens. However, anti- B. tropicalis IgE antibodies cross-react with Ascaris lumbricoides antigens, hindering the diagnosis of allergy to this mite. In this study, B. tropicalis recombinant allergens were evaluated with the purpose of developing an immunodiagnostic assay for allergy to this mite with greater ...
Tópico(s): Contact Dermatitis and Allergies
2013 - BioMed Central | BMC Immunology
Produção Nacional
Revisado por pares
Luana Novaes Santos, Margareth Borges Coutinho Gallo, Eduardo Sérgio da Silva, Camila Alexandrina Figueiredo, P. J. Cooper, Maurício L. Barreto, Sandra María Correia Loureiro, Lain Carlos Pontes-de-Carvalho, Neuza Maria Alcântara‐Neves,
Infections with Trichuris trichiura and other trichurid nematodes have been reported to display protective effects against atopy, allergic and autoimmune diseases. The aims of the present study were to investigate the immunomodulatory properties of T. trichiura adult worm extract (TtE) and its fractions (TtEFs) on the production of cytokines by peripheral blood mononuclear cells and to identify their proteinaceous components. Fourteen TtEFs were obtained by ion exchange chromatography and tested for ...
Tópico(s): Research on Leishmaniasis Studies
2013 - Wiley | Parasite Immunology
Produção Nacional
Marta Santos Serafim Machado, Hugo Bernardino Ferreira Silva, Raimon Rios, Anaque Pires de Oliveira, Noma Vilany Queiroz Carneiro, Ryan Santos Costa, William Santos Alves, Fabio-Luis Meneses Souza, Eudes da Silva Velozo, Silvana Alves de Souza, Tânia Maria Sarmento Silva, Maria Lenise Silva, Lain Carlos Pontes-de-Carvalho, Neuza Maria Alcântara‐Neves, Camila Alexandrina Figueiredo,
The prevalence of allergic diseases such as asthma has significantly increased worldwide, making it a public health concern. There is an urgent need for new anti-inflammatory agents with selective pharmacology and lower toxicity. Plant extracts have been used for centuries in traditional medicine to alleviate inflammatory diseases. In this work, we evaluated the anti-allergic activity of Cymbopogon citratus (Cy), a medicinal herb used by folk medicine to treat asthma.We used a murine model of respiratory ...
Tópico(s): Herbal Medicine Research Studies
2015 - BioMed Central | BMC Complementary and Alternative Medicine
Produção Nacional
Revisado por pares
Tatiane Oliveira, Keina Maciele Campos Dourado, Ana Tereza Cerqueira Lima, Tamires Cana Brasil Carneiro, Eudes da Silva Velozo, Ingrid Christie Alexandrino Ribeiro de Melo, Eugênia Abrantes de Figueiredo, Eduardo de Jesus Oliveira, Darizy Flávia Silva Amorim de Vasconcelos, Lain Carlos Pontes-de-Carvalho, Neuza Maria Alcântara‐Neves, Camila Alexandrina Figueiredo,
Abstract Background Asthma is an inflammatory condition characterized by airway hyperresponsiveness and chronic inflammation. The resolution of inflammation is an essential process to treat this condition. In this study we investigated the effect of Allium cepa L. extract (AcE) and quercetin (Qt) on cytokine and on smooth muscle contraction in vitro and its therapeutic potential in a murine model of asthma. Methods AcE was obtained by maceration of Allium cepa L. and it was standardized in terms of ...
Tópico(s): Mast cells and histamine
2015 - Springer Nature | DARU Journal of Pharmaceutical Sciences
Produção Nacional
Dercílio Júnior Verly Lopes, Juarez Benigno Paes, Ivaldo Pontes Jankowsky, Pedro Gutemberg de Alcântara Segundinho, Graziela Baptista Vidaurre,
RESUMO Avaliaram-se os efeitos do teor de umidade e classe diamétrica na qualidade do tratamento de moirões de Corymbia torelliana e Eucalyptus grandis x Eucalyptus urophylla. Utilizaram-se 108 moirões, sendo 36 tratados e 18 não tratados, com 2,20 m de comprimento e umidade de 15 a 20%; 20 a 30%; 30 a 40%, e diâmetros de 8 a 10 cm; 10 a 12 cm; 12 a 14 cm. No tratamento, foram utilizados 2% de ingredientes ativos de CCA-C, vácuo inicial e final de 550 mmHg (30 min), pressão de 11 kgf cm-2 (1 h). Os ...
Tópico(s): Soil Management and Crop Yield
2017 - UNIVERSIDADE FEDERAL RURAL DO RIO DE JANEIRO | Floresta e Ambiente
Produção Nacional
Revisado por pares
Glauber Ribeiro de Sousa Araújo, Carolina de Lima Alcantara, Noêmia Rodrigues, Wanderley de Souza, Bruno Pontes, Susana Frasés,
Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals. It is surrounded by three concentric structures that separate the cell from the extracellular space: the plasma membrane, the cell wall and the polysaccharide (PS) capsule. Although several studies have revealed the chemical composition of these structures, little is known about their ultrastructural organization and remodeling during C. neoformans budding events. Here, by combining ...
Tópico(s): Nail Diseases and Treatments
2021 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Roseane Pontes Aguiar, Maria Raquel Alcântara de Miranda, A. M. P. Lima, J. L. Mosca, Renato de Azevedo Moreira, Joaquim Enéas-Filho,
Introduction . Films act as semi-permeable gaseous barriers capable of maintaining fruit postharvest quality; thus coatings consisting of non-traditional sources may represent an alternative tool for producers. The objective of our work was to investigate the effect of a galactomannan coating on postharvest quality and physiology of ‘Tommy Atkins’ mangoes. Materials and methods . Physiologically mature mangoes were divided into four lots and stored for 16 d. Control uncoated fruits (lot 1) were stored ...
Tópico(s): Phytochemicals and Antioxidant Activities
2011 - EDP Sciences | Fruits
Produção Nacional
Revisado por pares
Adriana M. Fróes, Cláudia V.D dos Santos, Manoel L Penha-Filho, Márcia Cristina Aquino Teixeira, Tânia Maria Correa Silva, Geraldo Gileno de Sá Oliveira, Washington L. C. dos‐Santos, Lain Carlos Pontes-de-Carvalho, Neuza Maria Alcântara‐Neves,
This work aims at identifying an effective protocol to raise anti-Leishmania chagasi amastigote antibodies in different animal species. Protocols of immunization by subcutaneous injections of L. chagasi promastigote and amastigote lysates or by either intravenous or subcutaneous inoculation of live metacyclic promastigotes were assessed in mice, rabbits, and dogs. The immunization with live promastigotes produced a strong humoral immune response against L. chagasi amastigotes in all three animal ...
Tópico(s): Eosinophilic Disorders and Syndromes
2004 - Elsevier BV | Veterinary Immunology and Immunopathology
Produção Nacional
Revisado por pares
Neuza Maria Alcântara‐Neves, Samuel J Badaró, Mariese CA dos Santos, Lain Pontes–de-Carvalho, Maurício L. Barreto,
The elucidation of factors that trigger the development of transient wheezing in early childhood may be an important step toward understanding the pathogenesis of asthma and other allergic diseases later in life. Transient wheezing has been mainly attributed to viral infections, although sensitisation to aeroallergens and food allergens may occur at an early age. In developing countries, intestinal helminthic infections have also been associated with allergy or atopy-related disorders. The aim of ...
Tópico(s): Eosinophilic Esophagitis
2010 - BioMed Central | Respiratory Research
Produção Nacional
Revisado por pares
Evandro Moraes-Silva, Fabiana Rodrigues Antunes, Márcio Silva Rodrigues, Fred da Silva Julião, Artur Dias-Lima, Valderez Lemos-de-Sousa, Adriano Costa de Alcântara, Eliana Almeida Gomes Reis, Maria Nakatani, Roberto Badaró, Mitermayer Galvão dos Reis, Lain Pontes–de-Carvalho, Carlos Roberto Franke,
Tópico(s): Trypanosoma species research and implications
2006 - Elsevier BV | Acta Tropica
... com a Serra da Estrela. A construção da ponte de Alcântara contribuiu para alterar um esquema viário em que o principal acesso à Serra se fazia a partir da via Emerita-Asturica, situando-se a ponte no cenário de promoção das civitates da região como factor determinante do desenvolvimento de uma densa rede viária centrada no eixo Mérida-Alcântara-Braga.
Tópico(s): Classical Studies and Legal History
2019 - Coimbra University Press | Conimbriga Revista de Arqueologia
... e das inspeções principais detalhadas, acometidas sobre a Ponte Romana de Alcántara (situada na Extremadura, Espanha) e sobre um bonde ...
Tópico(s): Historical and Architectural Studies
2024 - Brazilian Journal of Development | Brazilian Journal of Development
Produção Nacional
Revisado por pares
Camila Alexandrina Figueiredo, Neuza Maria Alcântara‐Neves, Leila Denise Alves Ferreira Amorim, Nivea B. Silva, Lain C. Pontes de Carvalho, Philip J. Cooper, Laura C. Rodrigues, Maurício L. Barreto,
Allergic and other immune-mediated diseases are complex disease states determined by interplay between host genetics and environmental factors. Environmental changes such as fewer infections and reduced exposure to microbial products have been suggested to have led to insufficient regulation of Th1 and Th2 immune responses, causing an increased incidence of inflammatory diseases. The objective of the present study was to investigate the effect of poor living environmental conditions on mitogen-induced ...
Tópico(s): Allergic Rhinitis and Sensitization
2011 - Elsevier BV | Clinical Immunology
Produção Nacional
Revisado por pares
Vitor Camilo Cavalcante Dattoli, Rafael Veiga, Sérgio Souza da Cunha, Lain Carlos Pontes-de-Carvalho, Maurício L. Barreto, Neuza Maria Alcântara‐Neves,
Abstract Background: Helicobacter pylori infection has been proved to be of great relevance to public health in unindustrialized countries, especially in low socioeconomic groups. Poor hygiene, deficient sanitation, and crowded conditions have been reported as risk factors for this infection. In this work, we investigated whether social and demographic characteristics were associated with anti‐ H. pylori IgG antibodies in 1104 children aged 4–11 years old from Salvador, a large city located in northeastern ...
Tópico(s): Gastrointestinal disorders and treatments
2010 - Wiley | Helicobacter
Produção Nacional
Revisado por pares
Vitor Camilo Cavalcante Dattoli, Rafael Veiga, Sérgio Souza da Cunha, Lain Pontes–de-Carvalho, Maurício L. Barreto, Neuza Maria Alcântara‐Neves,
Toxoplasmosis is a cosmopolitan protozoan infection. Data regarding risk factors for the post-natal acquisition of Toxoplasma gondii infection in childhood are limited. We conducted a serological survey for T. gondii IgG antibodies and associated risk factors in 1,217 children 4–11-yr-old from Salvador, Brazil, using a commercial ELISA kit; antibodies were found in 17.5% of the children. Age (OR = 2.18; 95% CI: 1.50–3.17) and maternal schooling level (OR = 0.62; 95% CI: 0.42–0.92) were negatively associated ...
Tópico(s): Sex work and related issues
2011 - American Society of Parasitologists | Journal of Parasitology
Produção Nacional
Revisado por pares
Lívia Ribeiro Mendonça, Rafael Veiga, Vitor Camilo Cavalcante Dattoli, Camila Alexandrina Figueiredo, Rosemeire Leovigildo Fiaccone, Jackson Santos, Álvaro A. Cruz, Laura C. Rodrigues, Philip J. Cooper, Lain Carlos Pontes-de-Carvalho, Maurício L. Barreto, Neuza Maria Alcântara‐Neves,
Toxocara canis and T. cati are parasites of dogs and cats, respectively, that infect humans and cause human toxocariasis. Infection may cause asthma-like symptoms but is often asymptomatic and is associated with a marked eosinophilia. Previous epidemiological studies indicate that T. canis infection may be associated with the development of atopy and asthma.To investigate possible associations between Toxocara spp. seropositivity and atopy and childhood wheezing in a population of children living ...
Tópico(s): Insects and Parasite Interactions
2012 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Gustavo Cabral‐Miranda, Joílson Ramos de Jesus, Pablo Rafael Silveira Oliveira, Gabriela S G Britto, Lain Carlos Pontes-de-Carvalho, Rosa F. Dutra, Neuza Maria Alcântara‐Neves,
Diseases such as leishmaniases are important causes of morbidity and mortality in Brazil, and their diagnoses need to be improved. The use of monoclonal antibodies has ensured high specificity to immunodiagnosis. The development of an immunosensor, coupling a monoclonal antibody to a bioelectronic device capable of quickly detecting Leishmania sp. antigens both qualitatively and quantitatively, is a promising alternative for the diagnosis of leishmaniasis due to its high specificity, low cost, and ...
Tópico(s): Trypanosoma species research and implications
2014 - American Society of Parasitologists | Journal of Parasitology
... da localização dos municipia mencionados na inscrição da ponte de Alcântara, CIL II 760.Palavras chave: Orjais (Covilhã, Portugal); ...
Tópico(s): Archaeological and Geological Studies
2003 - Coimbra University Press | Conimbriga Revista de Arqueologia
Jorge de Alarcão, Pedro C. Carvalho, José Luís Madeira, Marcos Osório,
... da localização dos municipia mencionados na inscrição da ponte de Alcântara, CIL II 760.Palavras chave: Orjais (Covilhã, Portugal); ...
Tópico(s): Ancient Mediterranean Archaeology and History
2013 - Coimbra University Press | Conimbriga Revista de Arqueologia