Kalina K Stantcheva, Loredana Iovino, Rahul Dhandapani, Concepción Martínez, Laura Castaldi, Linda Nocchi, Emerald Perlas, Carla Portulano, Martina Pesaresi, Kalyanee Shirlekar, Fernanda de Castro Reis, Triantafyllos Paparountas, Daniel Bilbao, Paul A. Heppenstall,
... Search for more papers by this author Carla Portulano Carla Portulano EMBL Mouse Biology Unit, Monterotondo, Italy Search for ... Search for more papers by this author Carla Portulano Carla Portulano EMBL Mouse Biology Unit, Monterotondo, Italy Search for ...
Tópico(s): Circadian rhythm and melatonin
2016 - Springer Nature | EMBO Reports
... in the intestineJuan Pablo Nicola, Cécile Basquin*, Carla Portulano*, Andrea Reyna-Neyra, Monika Paroder, and Nancy Carrasco1 ...
Tópico(s): Thyroid Disorders and Treatments
1961 - American Physiological Society | Physiological Reviews
... in the intestineJuan Pablo Nicola, Cécile Basquin*, Carla Portulano*, Andrea Reyna-Neyra, Monika Paroder, and Nancy Carrasco1 ...
Tópico(s): Thyroid Disorders and Treatments
1964 - American Physiological Society | Physiological Reviews
... active iodine uptake.10Nicola J.P. Basquin C. Portulano C. Reyna-Neyra A. Paroder M. Carrasco N. ...
Tópico(s): Neonatal Health and Biochemistry
2009 - Elsevier BV | Gastroenterology
Juan P. Nicola, Cécile Basquin, Carla Portulano, Andrea Reyna‐Neyra, Monika Paroder, Nancy Carrasco,
Absorption of dietary iodide, presumably in the small intestine, is the first step in iodide (I − ) utilization. From the bloodstream, I − is actively taken up via the Na + /I − symporter (NIS) in the thyroid for thyroid hormone biosynthesis and in such other tissues as lactating breast, which supplies I − to the newborn in the milk. The molecular basis for intestinal I − absorption is unknown. We sought to determine whether I − is actively accumulated by enterocytes and, if so, whether this process is mediated by ...
Tópico(s): Chemical Analysis and Environmental Impact
2008 - American Physical Society | AJP Cell Physiology
Fernanda Carvalho Poyraz, Matthias Quick,
... mediated by NIS (Nicola, J. P., Basquin, C., Portulano, C., Reyna-Neyra, A., Paroder, M., and Carrasco, ...
Tópico(s): Amino Acid Enzymes and Metabolism
2010 - Elsevier BV | Journal of Biological Chemistry
Orsolya Dohán, Carla Portulano, Cécile Basquin, Andrea Reyna‐Neyra, L. Mario Amzel, Nancy Carrasco,
The Na + /I − symporter (NIS) is a key plasma membrane protein that mediates active I − uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na + per I − . In the thyroid, NIS-mediated I − uptake is the first step in the biosynthesis of the iodine-containing thyroid hormones, which are essential early in life for proper CNS development. In the lactating breast, NIS mediates the translocation of I − to the milk, thus supplying this essential anion to the nursing newborn. ...
Tópico(s): Water Treatment and Disinfection
2007 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Kerry J. Rhoden, Stefano Cianchetta, Valeria Stivani, Carla Portulano, Luis J. V. Galietta, Giovanni Romeo,
The sodium iodide symporter (NIS) mediates iodide (I(-)) transport in the thyroid gland and other tissues and is of increasing importance as a therapeutic target and nuclear imaging reporter. NIS activity in vitro is currently measured with radiotracers and electrophysiological techniques. We report on the development of a novel live cell imaging assay of NIS activity using the I(-)-sensitive and genetically encodable yellow fluorescent protein (YFP) variant YFP-H148Q/I152L. In FRTL-5 thyrocytes stably ...
Tópico(s): Amino Acid Enzymes and Metabolism
2006 - American Physical Society | AJP Cell Physiology
Claire Lacoste, Julie Hervé, Myriam Bou Nader, Alexandre Dos Santos, Nicolas Moniaux, Yannick Valogne, Rodrick Montjean, Olivier Dorseuil, Didier Samuel, Doris Cassio, Carla Portulano, Nancy Carrasco, Christian Bréchot, J Faivre,
Abstract A number of solute carrier (SLC) proteins are subject to changes in expression and activity during carcinogenesis. Whether these changes play a role in carcinogenesis is unclear, except for some nutrients and ion carriers whose deregulation ensures the necessary reprogramming of energy metabolism in cancer cells. In this study, we investigated the functional role in tumor progression of the sodium/iodide symporter (NIS; aka SLC5A5), which is upregulated and mislocalized in many human carcinomas. ...
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - American Association for Cancer Research | Cancer Research
Carla Portulano, Monika Paroder‐Belenitsky, Nancy Carrasco,
The Na(+)/I(-) symporter (NIS) is the plasma membrane glycoprotein that mediates active I(-) transport in the thyroid and other tissues, such as salivary glands, stomach, lactating breast, and small intestine. In the thyroid, NIS-mediated I(-) uptake plays a key role as the first step in the biosynthesis of the thyroid hormones, of which iodine is an essential constituent. These hormones are crucial for the development of the central nervous system and the lungs in the fetus and the newborn and for ...
Tópico(s): Neuroendocrine Tumor Research Advances
2013 - Oxford University Press | Endocrine Reviews
Shane J. Morley, Yanmei Qi, Loredana Iovino, Laura Andolfi, Da Guo, Nereo Kalebic, Laura Castaldi, Christian Tischer, Carla Portulano, Giulia Bolasco, Kalyanee Shirlekar, Claudia M. Fusco, Antonino Asaro, Federica Fermani, Mayya Sundukova, Ulf Matti, Luc Reymond, Adele De Ninno, Luca Businaro, Kai Johnsson, Marco Lazzarino, Jonas Ries, Yannick Schwab, Jing Hu, Paul A. Heppenstall,
At its most fundamental level, touch sensation requires the translation of mechanical energy into mechanosensitive ion channel opening, thereby generating electro-chemical signals. Our understanding of this process, especially how the cytoskeleton influences it, remains unknown. Here we demonstrate that mice lacking the α-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli. We show that all cutaneous afferent subtypes, including ...
Tópico(s): Cellular transport and secretion
2016 - eLife Sciences Publications Ltd | eLife
Marco Dauriz, Giovanni Targher, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Gian Luigi Nicolosi, Roberto Marchioli, Gianni Tognoni, Roberto Latini, Franco Cosmi, Luigi Tavazzi, Aldo P. Maggioni, Simona Barlera, Maria Grazia Franzosi, Aldo P. Maggioni, Maurizio Porcu, Maria Grazia Franzosi, Aldo P. Maggioni, Maurizio Porcu, Salim Yusuf, Fulvio Camerini, Jay N. Cohn, Adriano Decarli, Bertram Pitt, Peter Sleight, Philip A. Poole‐Wilson, Enrico Geraci, Marino Scherillo, Gianna Fabbri, Barbara Bartolomei, Daniele Bertoli, Franco Cobelli, Claudio Fresco, Antonietta Ledda, Giacomo Levantesi, Cristina Opasich, F Rusconi, Gianfranco Sinagra, Fabio Maria Turazza, Alberto Volpi, Martina Ceseri, G. Alongi, Antonio Atzori, Filippo Bambi, Desirée Bastarolo, Francesca Bianchini, Iacopo Cangioli, Vittoriana Canu, Concetta Caporusso, Gabriele Cenni, Laura Cintelli, Michele Cocchio, Alessia Confente, Eva Fenicia, Giorgio Friso, Marco Gianfriddo, Gianluca Grilli, Beatrice Lazzaro, Giuseppe Lonardo, A Luise, Rachele Nota, Mariaelena Orlando, Rosaria Petrolo, Chiara Pierattini, Valeria Pierota, Alessandro Provenzani, Velia Quartuccio, Anna Ragno, Chiara Serio, Alvise Spolaor, Arianna Tafi, Elisa Tellaroli, Stefano Ghio, Elisa Ghizzardi, Serge Masson, Maria Grazia Franzosi, Lella Crociati, Maria Teresa La Rovere, Ugo Corrà, A Finzi, Simona Barlera, Marco Gorini, Valentina Milani, G Orsini, Elisa Bianchini, Silvia Cabiddu, Ilaria Cangioli, L Cipressa, Maria Lucia Cipressa, Giuseppina Di Bitetto, B. Ferri, Luisa Galbiati, Andrea Lorimer, Carla Pera, P. Priami, Antonella Vasamì, Tiziano Moccetti, Maria Grazia Rossi, Elena Pasotti, F. Vaghi, P L Roncarolo, M.T. Zunino, Fadi Matta, E. Actis Perinetto, Fiorenzo Gaïta, G. Azzaro, Marco Zanetta, Anna Maria Paino, U Parravicini, Daniela Vegis, Rosa Conte, Pietro Manuel Ferraro, Alberto De Bernardi, S Morelloni, M. Fagnani, Pietro Greco Lucchina, Laura Montagna, Emilia Bellone, Diego Sappè, Francesca Ferraro, M. Delucchi, Stéphane Reynaud, M. Doré, Alessandra Brocca, N Massobrio, Liao Bo, Rita Trinchero, Massimo Imazio, G Brocchi, A. Nejrotti, L. Rissone, S Gabasio, Chiara Zocchi, Sabrina Randazzo, A. Crenna, Pantaleo Giannuzzi, Ezio Bonanomi, Alessandro Mezzani, M. Marchi, G. Begliuomini, C.A. Gianonatti, Antonello Gavazzi, A. Grosu, Livio Dei, Savina Nodari, Polyxeni Garyfallidis, Alessandra Bertoletti, C Bonifazi, S. Arisi, F. Mascaro, M. Fraccarollo, Simonetta Dell’Orto, M. Sfolcini, F. Bortolini, D Raccagni, A Turelli, Marta Elena Santarone, Emilio Miglierina, L. Sormani, R Jemoli, F. Tettamanti, Salvatore Pirelli, Cristina Bianchi, S. Fidalgo Verde, Marco Valerio Mariani, Vigilio Ziacchi, Alessandro Maria Ferrazza, Antonio Russo, Monica Bortolotti, Gianfranco Pasini, Alberto Volpi, Kirsty Jones, D. Cuzzucrea, G Gullace, Carmine Carbone, Antonio Granata, Stefano De Servi, Gianluca Rosso, C. Inserra, E Renaldini, C Zappa, Marco Moretti, Roberto Zanini, Marina Ferrari, E Moroni, A. Cei, C. Lissi, E. Dovico, C Fiorentini, Pietro Palermo, B Brusoni, M. Negrini, Joanna Heyman, Gian Battista Danzi, A Finzi, Maria Frigerio, Fabio Maria Turazza, L. Beretta, A Sachero, Franco Casazza, Lidia Squadroni, Federico Lombardi, Luigi Marano, Alberto Margonato, Gabriele Fragasso, Oreste Febo, Eleonora Aiolfi, Francesca Olmetti, A Grieco, V. Antonazzo, Giorgina Specchia, Andrea Mortara, Francesco Robustelli, Marco Songini, Carlo Schweiger, Anna Frisinghelli, Michela Palvarini, Chiara Campana, Laura Scelsi, Nina Ajmone Marsan, Franco Cobelli, Alessandra Gualco, Cristina Opasich, S. De Feo, Riccardo Mazzucco, Maria Iannone, Tommaso Diaco, Daniela Zaniboni, Gloria Milanesi, D. Nassiacos, Sabina Meloni, Paolo Giani, T. Nicoli, C. Malinverni, A. Gusmini, L Pozzoni, Giuliana Bisiani, P. Margaroli, A. Schizzarotto, A. Daverio, Giuseppe Occhi, N Partesana, P Bandini, M.G. Rosella, S Giustiniani, G Cucchi, Roberto F.E. Pedretti, Rosa Raimondo, Raffaella Vaninetti, Antonella Fedele, Isabella Ghezzi, Enea Rezzonico, Jorge Antonio Salerno Uriarte, Fabrizio Morandi, Fabrizio Salvucci, Cinzia Valenti, Giorgio Maria Paolo Graziano, Massimo Romanò, Claudio Cimminiello, I. Mangone, Mauro Lombardo, Patrizia Quorso, G. P. Marinoni, Maria L. Breghi, M. Erckert, Anton Dienstl, G. Mirante Marini, Carlo Stefenelli, G. Cioffi, Ewa Otto Buczkowska, A Bonanome, F. Bazzanini, Lucia Parissenti, Claudia Serafini, Giuseppe Catania, Luigi Tarantini, G. Rigatelli, Silvana Boni, Andrea Pasini, Enos Masini, Alberto Zampiero, M Zanchetta, L. Franceschetto, Pietro Delise, César Marcon, Antonio Sacchetta, L. Borgese, L Artusi, P Casolino, F Corbara, A. Banzato, Mario Barbiero, M.P. Aldegheri, R. Bazzucco, G. Crivellenti, Antonio Raviele,
Background The independent prognostic impact of diabetes mellitus ( DM ) and prediabetes mellitus (pre‐ DM ) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre‐ DM on survival outcomes in the GISSI ‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) ...
Wiley
Rahul Dhandapani, Cynthia M. Arokiaraj, Francisco J. Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G. Lechner, Paul A. Heppenstall,
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing neurons are ablated are less sensitive to the lightest touch under basal conditions, and fail to develop mechanical allodynia in a model of neuropathic pain. Moreover, selective optogenetic ...
Tópico(s): Ion Channels and Receptors
2018 - Nature Portfolio | Nature Communications
Maria M. Magiera, Puja Singh, Sudarshan Gadadhar, Carsten Janke,
... Guo D. Kalebic N. Castaldi L. Tischer C. Portulano C. Bolasco G. et al.Acetylated tubulin is ...
Tópico(s): Epigenetics and DNA Methylation
2018 - Cell Press | Cell
M. Gréco, Federico Cucci, Pierfrancesco Portulano, Roberta Lazzari, Cosimo Caldararo, Fernando Lencastre Sicuro, Carmelo Catanese, Giambattista Lobreglio,
Vaccine-induced immunity is at present the main strategy to stop the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Recent evidences suggested a protective effect of influenza vaccination against coronavirus disease 2019 (COVID-19) severity, while impact on the immune response to BNT162b2 messenger RNA (mRNA) vaccine is under investigation.We aimed to evaluate this aspect in a cohort of 297 healthcare workers (108 males, 189 females) after seasonal influenza vaccination compared ...
Tópico(s): Respiratory viral infections research
2021 - Elmer Press Inc. | Journal of Clinical Medicine Research
Linda Nocchi, Carla Portulano, Federica Franciosa, Balint Doleschall, Mirela Panea, Nainika Roy, Mariano Maffei, Alessandra Gargano, Emerald Perlas, Paul A. Heppenstall,
Abstract Nerve growth factor (NGF) and its receptors TrkA and p75 play a key role in the development and function of peripheral nociceptive neurons. Here, we describe novel technology to selectively photoablate TrkA-positive nociceptors through delivery of a phototoxic agent coupled to an engineered NGF ligand and subsequent near-infrared illumination. We demonstrate that this approach allows for on demand and localized reversal of pain behaviors in mouse models of acute, inflammatory, neuropathic, ...
Tópico(s): Neuropeptides and Animal Physiology
2019 - Lippincott Williams & Wilkins | Pain
... una toponimia que coincide con el más antiguo portulano conocido (la carta Pisana c.1270) y el ... de Shirazi de 1282, parece ser el segundo portulano más antiguo del que tenemos un específico conocimiento. ...
Tópico(s): Historical Astronomy and Related Studies
2023 - Taylor & Francis | Imago Mundi
... y musulmanes, con la revolución técnica de los portulanos.
Tópico(s): Historical Studies on Spain
2011 - | PH. Boletín del Instituto Andaluza del Patrimonio Histórico/PH/PH. Boletín del Instituto Andaluz del Patrimonio Histórico/Boletín informativo - Instituto Andaluz del Patrimonio Histórico
Joan Strawson, Michael L. Dourson, Qiyu Zhao,
... 97516187904. Crossref, Medline, Google ScholarFiguresReferencesRelatedDetailsCited By Dohán O, Portulano C, Basquin C, Reyna-Neyra A, Amzel L ...
Tópico(s): Radioactive contamination and transfer
2005 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
... dell’isola, vi è l’ufficio del Maestro Portulano dal quale transitano tutti i permessi («le tratte» ) ...
Tópico(s): Global Maritime and Colonial Histories
2008 - | Mélanges de l École française de Rome Italie et Méditerranée
El Portulano constituye un nuevo tipo de mapa, que aparece en el siglo XIII. Contemporáneo de las representaciones escolásticas ... siglo, sobrepasa en exactitud a todas ellas. Los Portulanos o cartas náuticas, ejecutadas por marinos, tienen como ... la época de realización de las cartas. El portulano que se presenta aquí, firmado por Joan Martines ...
Tópico(s): Historical Studies on Spain
1991 - University of Alicante | Investigaciones Geográficas
(1964). The Japanese portulanos of Portuguese origin of the XVIth and XVIIth centuries. Imago Mundi: Vol. 18, No. 1, pp. 24-44.
Tópico(s): Japanese History and Culture
1964 - Taylor & Francis | Imago Mundi
“Cartography and navigation: from the Portulano to the Spherical Chart, from 18th century to early 19th century”, by Ruben Alvarez, Jose Maria Olivero y Enrique Albornoz.
Tópico(s): Historical Studies on Spain
2011 - University of Murcia | Naveg mérica Revista electrónica editada por la Asociación Española de Americanistas
... formación de los cartógrafos y de los “maestros portulanos” en este vibrante contexto cultural como un camino ...
Tópico(s): Historical Studies on Spain
2022 - | Revista de Historia y Geografía
Tópico(s): Historical and Linguistic Studies
1986 - | Sharq Al-Andalus
Produção Nacional
Magali Gomes Nogueira, Mário De Biasi,
... representação cartográfica medieval a partir do gênero cartográfico Portulano, considerado por alguns como a base técnica da ...
Tópico(s): Medieval and Early Modern Iberia
2015 - | Terra Brasilis
Tópico(s): Information Science and Libraries
2016 - Brazilian National Archives | Acervo
Mario Arturo Ortíz Pérez, Azucena Pérez Vega,
... diferentes fechas y en una colección de mapas portulanos que datan de los siglos XVIII y XIX. ...
Tópico(s): Geography and Environmental Studies in Latin America
1999 - National Autonomous University of Mexico | Investigaciones Geográficas Boletín del Instituto de Geografía
Produção Nacional
Francisco de Assis Veloso Filho,
... arabes, com a tradicao da cartografia nautica (cartas portulano) e as navegacoes e descobertas geograficas da primeira ... con la tradicion de la cartografia nautica (cartas portulano) y las navegaciones y descubrimientos geograficos de la ...
Tópico(s): Linguistics and Language Studies
2010 - UNIVERSIDADE FEDERAL DO CEARÁ | Mercator
... das fontes utilizadas para a construção do Padrão Portulano, gênero cartográfico entendido como de vital importância para ... produção, materializada no famoso “Atlas Catalão” e nasCartas Portulano maiorquinas.
Tópico(s): Religious Tourism and Spaces
2014 - | Cadernos de Língua e Literatura Hebraica